Gene Dmel\Eip78C

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General Information

Symbol

Dmel\Eip78C

Species

D. melanogaster

Name

Ecdysone-induced protein 78C

Annotation symbol

CG18023

Feature type

protein_coding_gene

FlyBase ID

FBgn0004865

Gene Model Status

Current

Stock availability

25 publicly available

Also Known As

E78, E78B, E78A, DR-78, NR1E1

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

78C2-78C3

Sequence location

3L:21,219,709..21,259,603 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene Ecdysone-induced protein 78C is referred to in FlyBase by the symbol Dmel\Eip78C (CG18023, FBgn0004865). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity. It is reported to be involved in the biological process: instar larval or pupal development. 43 alleles are reported. The phenotypes of these alleles are annotated with: eye; ommatidium; dorsal appendage. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Nuclear hormone receptor, ligand-binding; Nuclear hormone receptor, ligand-binding, core; Steroid hormone receptor; Zinc finger, NHR/GATA-type; Zinc finger, nuclear hormone receptor-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1640770_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Eip78C. Gene sequence location is 3L:21219709..21259603.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

78C2-78C3

Limits computationally determined from genome sequence between P{EP}chb^EP3403 and P{PZ}ppl⁰⁰²¹⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

78C4-78C6

(Martin-Blanco, 1993.4.20)

78D-78D

(determined by in situ hybridisation)

(Martin-Blanco and Kornberg, 1993)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Eip78C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.40

Unconventional translation start (CUG) postulated; FBrf0064719

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Low-frequency RNA-Seq exon junction(s) not annotated.

gene_with_start_codon_CUG ; SO:0001740

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Eip78C-RA

FBtr0078306

NM_079471

5223

862

Eip78C-RB

FBtr0078307

NM_168892

3832

392

Eip78C-RD

FBtr0306157

NM_001259933

4192

862

Eip78C-RE

FBtr0306158

NM_001259934

3541

862

Additional Transcript Data & Comments

Reported size (kB)

4.8, 4.3, 4.1, 4.0, 3.5, 3.2, 2.6 (northern blot)

(Stone and Thummel, 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Eip78C-PA

FBpp0077963

94.7

862

5.14

NP_524195

AAF51692

Eip78C-PB

FBpp0077964

43.2

392

6.51

NP_730609

AAN12161

Eip78C-PD

FBpp0297287

94.7

862

5.14

NP_001246862

AFH04533

Eip78C-PE

FBpp0297288

94.7

862

5.14

NP_001246863

AFH04534

Additional Polypeptide Data & Comments

Reported size (kDa)

864, 390 (aa); 95.9, 43.8 (kD)

(Stone and Thummel, 1993)

Comments

Translation initiates at a CUG codon. This protein lacks a DNA-binding domain but shares the ligand-binding/dimerization domain with the other major protein product of the Eip78C gene, Eip78C⁺P864.

(Stone and Thummel, 1993)

One of a couple of protein products.

(FlyBase, 1992-, FlyBase, 1992-)

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Nuclear hormone receptor, ligand-binding, core (IPR000536)

Zinc finger, nuclear hormone receptor-type (IPR001628)

Steroid hormone receptor (IPR001723)

Nuclear hormone receptor, ligand-binding (IPR008946)

Zinc finger, NHR/GATA-type (IPR013088)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P45447

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage

(Stone and Thummel, 1993)

Comment:reference states 32-48 hr post-hatching

pharate adult stage P8

(Stone and Thummel, 1993)

Comment:reference states 48-56 hr APF

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

second instar larval stage

(Stone and Thummel, 1993)

Comment:reference states 32-48 hr post-hatching

wandering third instar larval stage -- prepupal stage P4

organism

(Stone and Thummel, 1993)

Comment:-3-12 hr APF

third instar larval stage L2 -- prepupal stage P4

organism

(Stone and Thummel, 1993)

Comment:-3-12 hr APF

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		7.425
Larval Midgut		17.9
Larval Hindgut		30.9
Larval Malpighian Tubules		57.4
Larval Fat Body		164.9
Larval Salivary Gland		7.5
Larval Trachea		1.975
Larval Carcass		63.9
Adult Head		19.2
Adult Eye		4
Adult Brain		59.9
Adult Thoracic-Abdominal Ganglion		78.7
Adult Crop		6.1
Adult Midgut		12.8
Adult Hindgut		16.3
Adult Malpighian Tubules		4
Adult Fat Body		3.6
Adult Salivary Gland		4.2
Adult Heart		6.6
Adult VirginFemale Spermatheca		3
Adult InseminatedFemale Spermatheca		2.4
Adult Ovary		2.5
Adult Testis		5.8
Adult Male Accessory Gland		10.8
Adult Carcass		5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	no informative data
NA	Eye	4
NA	Brain	59.9
7.425	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	78.7
NA	Crop	6.1
no informative data	Midgut	no informative data
no informative data	Hindgut	no informative data
no informative data	Malpighian Tubules	4
164.9	Fat Body	3.6
7.5	Salivary Gland	4.2
NA	Heart	6.6
1.975	Trachea	NA
NA	VirginFemale Spermatheca	3
NA	InseminatedFemale Spermatheca	2.4
NA	Ovary	2.5
NA	Testis	5.8
NA	Male Accessory Gland	no informative data
no informative data	Carcass	5

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		141
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		66
salivary gland, white prepupae		377
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		43
fat body, pupae P8		144
carcass, larvae L3 wandering		61
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		(141)
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		(66)
salivary gland, white prepupae		(377)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		(43)
fat body, pupae P8		(144)
carcass, larvae L3 wandering		(61)
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		(141)
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		66
salivary gland, white prepupae		(377)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		43
fat body, pupae P8		(144)
carcass, larvae L3 wandering		61
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		141
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		66
salivary gland, white prepupae		377
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		43
fat body, pupae P8		144
carcass, larvae L3 wandering		61
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		141
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		66
salivary gland, white prepupae		377
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		43
fat body, pupae P8		144
carcass, larvae L3 wandering		61
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		(141)
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		(66)
salivary gland, white prepupae		(377)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		(43)
fat body, pupae P8		(144)
carcass, larvae L3 wandering		(61)
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		141
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		66
salivary gland, white prepupae		(377)
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		43
fat body, pupae P8		(144)
carcass, larvae L3 wandering		61
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		9
central nervous system, larvae L3		15
central nervous system, pupae P8		141
head, virgin 1-day female		12
head, virgin 4-day female		8
head, virgin 20-day female		5
head, mated 1-day female		10
head, mated 4-day female		7
head, mated 20-day female		5
head, mated 1-day male		16
head, mated 4-day male		16
head, mated 20-day male		10
salivary gland, larvae L3 wandering		66
salivary gland, white prepupae		377
digestive system, larvae L3 wandering		9
digestive system, 1-day adult		1
digestive system, 4-day adult		1
digestive system, 20-day adult		1
fat body, larvae L3 wandering		4
fat body, white prepupae		43
fat body, pupae P8		144
carcass, larvae L3 wandering		61
carcass, 1-day adult		2
carcass, 4-day adult		1
carcass, 20-day adult		1
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		0
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		82
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		(28)
white prepupae new		(27)
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		(82)
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		82
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		82
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		82
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		(82)
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		82
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		0
embryo 02-04hr		0
embryo 04-06hr		0
embryo 06-08hr		0
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		6
embryo 14-16hr		4
embryo 16-18hr		8
embryo 18-20hr		4
embryo 20-22hr		2
embryo 22-24hr		2
larva L1		1
larva L2		2
larva L3 12hr old		1
larva L3 puffstage 1-2		0
larva L3 puffstage 3-6		3
larva L3 puffstage 7-9		28
white prepupae new		27
white prepupae 12hr		6
white prepupae 24hr		8
pupae 2d postWPP		82
pupae 3d postWPP		17
pupae 4d postWPP		5
adult male 01day		2
adult male 05day		2
adult male 30day		2
adult female 01day		1
adult female 05day		0
adult female 30day		1
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		2
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		2
embryonic Kc167		3
embryonic S1		0
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		1
wing disc ML-DmD8		0
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		14
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		5
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		2
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		(28)
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		25
cold shock, 4-day adult		21
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		1
Cadmium 50 mM 12 hrs, larvae L3		28
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		3
Copper 0.5 mM 12 hrs, larvae L3		1
Copper 15 mM 48 hrs, 4-day adult		4
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		1
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_25

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004865

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG18023-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Eip78C^GD4135

viable

Sterility

Allele

female fertile

Eip78C^A464.2M3

fertile

Eip78C^ME534

male fertile

Eip78C^A464.2M3

Other Phenotypes

Allele

visible, with Scer\GAL4^ey.PH

Eip78C^EP3468

visible, with Scer\GAL4^GMR.PF

Eip78C^EP521

Phenotype manifest in

Allele

dorsal appendage

eye, with Scer\GAL4^ey.PH

Eip78C^EP3468

eye, with Scer\GAL4^GMR.PF

Eip78C^EP521

ommatidium, with Scer\GAL4^ey.PH

Eip78C^EP3468

Classical Alleles ( 37 )

For All Classical Alleles Show

Allele of Eip78C	Class	Mutagen	Stocks	Known lesion
Eip78C^8h		X ray	2	Yes
Eip78C^5-HA-1510			1	--
Eip78C^5-HA-1656			1	--
Eip78C^A464.2M3	wild-type allele	P-element activity	1	Yes
Eip78C^CB-0173-3			1	--
Eip78C^CB-0240-3			1	--
Eip78C^CB-0671-3			1	--
Eip78C^CB-0773-3			1	--
Eip78C^d01289		P-element activity	1	--
Eip78C^d06271		P-element activity	1	--
Eip78C^e02853		piggyBac transposase	1	--
Eip78C^f02423		piggyBac transposase	1	--
Eip78C^f03021		piggyBac transposase	1	--
Eip78C^KG03241		P-element activity	1	--
Eip78C^MB01950			1	--
Eip78C^MI05764			1	--
Eip78C^NP0209			1	--
Eip78C^NP5376			1	--
Eip78C^NP5449			1	--
Eip78C^NP6608			1	--
Eip78C¹⁰¹	amorphic allele - genetic evidence		0	Yes
Eip78C⁰⁶⁹¹³		P-element activity	0	Yes
Eip78C^3f		X ray	0	Yes
Eip78C^80c		X ray	0	Yes
Eip78C^BG02657		P-element activity	0	--
Eip78C^CB-0093-3			0	--
Eip78C^d01965		P-element activity	0	--
Eip78C^d11467		P-element activity	0	--
Eip78C^EP3098		P-element activity	0	--
Eip78C^EP3468		P-element activity	0	--
Eip78C^EP521		P-element activity	0	--
Eip78C^G14526		P-element activity	0	--
Eip78C^ME1325		P-element activity	0	Yes
Eip78C^ME534		Delta2-3 P-element activity	0	Yes
Eip78C^ME726		P-element activity	0	--
Eip78C^ME915		P-element activity	0	Yes
Eip78C^unspecified			0	--

Alleles Carried on Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Eip78C	Mutagen	Stocks	Known lesion
Eip78C^GD4135	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Eip78C^{hs.T:Scer\GAL4.T:Ivir\HA1}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	1	Yes
Eip78C^JF02258	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Eip78C^{T:Avic\GFP-SF,T:Zzzz\FLAG}	in vitro construct - coding region fusion	1	Yes
Eip78C^B.hs	in vitro construct - regulatory fusion	0	Yes
Eip78C^HM05218	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2L)ppl⁰⁶⁹¹³

(Zinke et al., 1999)

Df(3L)ME1325

(Carpenter, 1994, Russell et al., 1996)

Df(3L)Pc-101

(Russell et al., 1996)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

heat-shock construct

P{hs-Eip78C-B}

P{hs-GAL4-E78.LBD.HA}

GAL4 construct

P{hs-GAL4-E78.LBD.HA}

UAS construct

P{GD4135}

P{TRiP.HM05218}

P{TRiP.JF02258}

characterization construct

PBac{Eip78C-GFP.FLAG}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

miscellaneous insertions

Mi{MIC}Eip78C^MI05764

P{?'lArB}Eip78C^ME534

P{?'lArB}Eip78C^ME915

P{GT1}Eip78C^BG02657

P{RS3}Eip78C^CB-0093-3

P{RS3}Eip78C^CB-0173-3

P{RS3}Eip78C^CB-0240-3

P{RS3}Eip78C^CB-0671-3

P{RS3}Eip78C^CB-0773-3

P{RS5}Eip78C^5-HA-1510

P{RS5}Eip78C^5-HA-1656

P{SUPor-P}Eip78C^KG03241

PBac{RB}Eip78C^e02853

PBac{WH}Eip78C^f02423

PBac{WH}Eip78C^f03021

insertion of enhancer trap binary system

Mi{ET1}Eip78C^MB01950

insertion of enhancer trap

P{lArB}Eip78C^A464.2M3

P{lArB}Eip78C^ME726

P{PZ}Eip78C⁰⁶⁹¹³

Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 9 terms )

Molecular Function

CV term

Evidence

References

ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity

inferred from sequence or structural similarity with UniProtKB:Q63503

(FlyBase, 1992-)

non-traceable author statement

(Swiss-Prot Project Members, 1995.6.1, Maglich et al., 2001)

sequence-specific DNA binding

inferred from electronic annotation with InterPro:IPR001628

(FlyBase Curators et al., 2004-)

sequence-specific DNA binding transcription factor activity

inferred from sequence or structural similarity with UniProtKB:Q63503

(FlyBase, 1992-)

steroid hormone receptor activity

inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR001723, InterPro:IPR008946

(FlyBase Curators et al., 2004-)

zinc ion binding

inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

instar larval or pupal development

non-traceable author statement

(Swiss-Prot Project Members, 1995.6.1)

regulation of transcription, DNA-dependent

inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR001628, InterPro:IPR001723, InterPro:IPR008946, InterPro:IPR013088

(FlyBase Curators et al., 2004-)

steroid hormone mediated signaling pathway

inferred from electronic annotation with InterPro:IPR000536, InterPro:IPR008946

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

nucleus

inferred from sequence or structural similarity with UniProtKB:Q63503

(FlyBase, 1992-)

non-traceable author statement

(Swiss-Prot Project Members, 1995.6.1)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Eip78C allele

Gene

References

unspecified

(Mueller et al., 2005)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0004865

Orthologs

OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6RR733

Dipteran inclusive ortholog search

EOG6Q58XS

Insect inclusive ortholog search

EOG6FFBX3

Arthropod inclusive ortholog search

EOG6JWSVR

Metazoa inclusive ortholog search

EOG6S528D

Orthologs in Drosophila Species (EOG6RR733)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14768

Drosophila persimilis

Dper\GL24673

Drosophila willistoni

Dwil\GK16819

Drosophila virilis

Dvir\GJ13881

Drosophila mojavensis

Dmoj\GI13134

Drosophila grimshawi

Dgri\GH12165

Drosophila grimshawi

Dgri\GH14972

Orthologs in non-Drosophila Dipterans (EOG6Q58XS)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\eip78c

Anopheles gambiae

Malaria mosquito

Agam\AGAP006571

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ016641

Orthologs in non-Dipteran Insects (EOG6FFBX3)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB41516

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG008289

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH16496

Atta cephalotes

Leafcutter ant

Acep\ACEP25357

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO12552

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL14839

Linepithema humile

Argentine ant

Lhum\LH24540

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB13678

Solenopsis invicta

Red fire ant

Sinv\SINV10413

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002307

Bombyx mori

Silkmoth

Bmor\BGIBMGA003895

Pediculus humanus

Human body louse

Phum\PHUM234430

Tribolium castaneum

Red flour beetle

Tcas\E78

Orthologs in non-Insect Arthropods (EOG6JWSVR)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\Insl6

Daphnia pulex

Water flea

Dpux\FBP2

Ixodes scapularis

Deer tick

Isca\ISCW020016

Orthologs in non-Arthropod Metazoa (EOG6S528D)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\cnr-14

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_013178gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003548gn

Danio rerio

Zebrafish

Drer\rorcb

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA14768

Drosophila persimilis

Dper\GL24673

Drosophila willistoni

Dwil\GK16819

Drosophila virilis

Dvir\GJ13881

Drosophila mojavensis

Dmoj\GI13134

Drosophila grimshawi

Dgri\GH12165

Stocks & Reagents

Stocks Listed in FlyBase ( 25 )

Bloomington

38637

w¹¹¹⁸; PBac{Eip78C-GFP.FLAG}VK00037

26718

y¹ v¹; P{TRiP.JF02258}attP2

Harvard

P{XP}Eip78C^d01289

P{XP}Eip78C^d06271

PBac{RB}Eip78C^e02853

PBac{WH}Eip78C^f02423

PBac{WH}Eip78C^f03021

Kyoto

123059

w¹¹¹⁸; P{RS3}Eip78C^CB-0173-3

123087

w¹¹¹⁸; P{RS3}Eip78C^CB-0240-3

123279

w¹¹¹⁸; P{RS3}Eip78C^CB-0671-3

123325

w¹¹¹⁸; P{RS3}Eip78C^CB-0773-3

VDRC

v10396

w¹¹¹⁸ P{GD4135}v10396

More stocks available...

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 134 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

MIP25931

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0004865

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

40345

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Eip78C anon-WO0172774.42 anon-WO0172774.44

(FlyBase, 1996-)

Additional comments

Source for merge of Eip78C anon-WO0172774.42 anon-WO0172774.44 was sequence comparison (date:051113).

(FlyBase, 1996-)

Other Comments

Gene expression is increased in response to the presence of two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Normal Eip78C gene function is not required for viability or fertility, and its disruption has no visible phenotype. Deletion and overexpression of Eip78C demonstrates it function is required for the maximal induction of a subset of late puffs.

(Russell et al., 1996)

Eip78C expression is temporally shifted throughout the onset of metamorphosis by Eip74EF mutations.

(Fletcher and Thummel, 1995)

This ecdysone inducible gene encodes two nested transcription units. The larger encodes a member of the nuclear hormone receptor superfamily, the smaller encodes a truncated version that lacks the DNA binding domain.

(Stone and Thummel, 1993)

Eip78C gene structure and gene regulation have been determined.

(Stone and Thummel, 1992)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

Entrez Gene - A searchable database of RefSeq genes.

•

40345

UniProtKB/Swiss-Prot

•

P45447

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

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Nuclear hormone receptor, ligand-binding, core (IPR000536)

Zinc finger, nuclear hormone receptor-type (IPR001628)

Steroid hormone receptor (IPR001723)

Nuclear hormone receptor, ligand-binding (IPR008946)

Zinc finger, NHR/GATA-type (IPR013088)

Linkouts

DroID - A comprehensive database of gene and protein interactions.

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FBgn0004865

DRSC - Results from RNAi screens.

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FBgn0004865

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

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FBgn0004865

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

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CG18023-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

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FBgn0004865

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

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40345

modMine - Data generated by the modENCODE project.

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FBgn0004865

Synonyms & Secondary IDs ( 18 )

Reported As

Symbol Synonym

anon-WO0172774.42

anon-WO0172774.44

CG18023

(Lee et al., 2003, Mount, 2001.8.14, Perkins et al., 2009, Perkins et al., 2009.3.31)

dE78

(Laudet and Adelmant, 1995)

DR-78

(Martin-Blanco, 1993.4.20, Martin-Blanco and Kornberg, 1993)

E78

(Thummel and Chory, 2002, Ohno, 1999, Nuclear Receptors Nomenclature Committee, 1999, Bryant et al., 1999, Bender et al., 1997, Escriva et al., 1997, Lam et al., 1997, Thummel, 1995, Fisk and Thummel, 1995, Huet et al., 1995, Segraves, 1994, Jindra, 1994, Palanker et al., 2006, King-Jones and Thummel, 2005, de Rosny et al., 2008, Beckstead et al., 2005, Dubrovsky et al., 2011)

E78A

(Thummel, 1993.8.27, Henrich and Brown, 1995, Horner et al., 1995, Sun and Song, 2006)

E78B

(Bialecki et al., 2002, Sullivan and Thummel, 2003, Basso et al., 2002, Thummel, 1993.8.27, Richards et al., 1999, Bryant et al., 1999, Lam et al., 1997, Fletcher et al., 1997, Henrich and Brown, 1995, Heimbeck et al., 1995, Fletcher and Thummel, 1995, Sinenko et al., 2010, Sun and Song, 2006)

E78D

(Stone and Thummel, 1992)

Eip78

(Zinke et al., 1999)

Eip78C

(Fichelson et al., 2012, Gradilla et al., 2011, Arancio et al., 2010, Liu and Lehmann, 2008, Zeitouni et al., 2007, Levis et al., 2011.12.16, Liu and Lehmann, 2008, Spokony and White, 2012.5.22, Kim et al., 2010)

EIP78C

(Ritter and Beckstead, 2010)

Eip 78C

(Kaplow et al., 2007)

Eip78D

NR1E1

(Nuclear Receptors Nomenclature Committee, 1999, King-Jones and Thummel, 2005)

Name Synonym

Ecdysone-induced protein 78C

(Cho et al., 2005, Fichelson et al., 2012, Zeitouni et al., 2007, Kaplow et al., 2007)

ecdysone induced protein 78C

(Kim et al., 2010)

nuclear hormone receptor

(Russell, 1996.6.28, Russell, 1996.6.28)

Secondary FlyBase IDs

FBgn0046387
FBgn0046388

References ( 92 )

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All references relating to this gene ( 92 )

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Research paper ( 44 )
Supplementary material ( 4 )
Review ( 12 )
Personal communication to FlyBase ( 14 )
Abstract ( 6 )
FlyBase analysis ( 3 )
DNA/RNA sequence record ( 5 )
Protein sequence record ( 1 )
Stock list ( 1 )
Patent ( 1 )
Curated genome annotation ( 1 )

Recent research papers ( 5 )

Fichelson et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(20): 7893--7898: Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. [FBrf0218313]
Hackney et al., 2012, PLoS ONE 7(11): e49105: Tissue damage disrupts developmental progression and ecdysteroid biosynthesis in Drosophila. [FBrf0220007]
Weber et al., 2012, PLoS ONE 7(4): e34745: Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073]
Dubrovsky et al., 2011, J. Biol. Chem. 286(38): 33689--33700: The Drosophila FTZ-F1 Nuclear Receptor Mediates Juvenile Hormone Activation of E75A Gene Expression through an Intracellular Pathway. [FBrf0215576]
Gradilla et al., 2011, Genetics 189(3): 871--883: Isoform-Specific Regulation of a Steroid Hormone Nuclear Receptor by an E3 Ubiquitin Ligase in Drosophila melanogaster. [FBrf0216551]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2011

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