FB2020_01, released Feb 12, 2020

Gene: Dmel\Gdi

Open Close
General Information
Symbol
Dmel\Gdi
Species
D. melanogaster
Name
GDP dissociation inhibitor
Annotation Symbol
CG4422
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004868
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
GDP dissociation inhibitor (Gdi) encodes a GDP-dissociation inhibitor. [Date last reviewed: 2019-09-19]
Other Summaries
Also Known As

dGDI, l(2)N7-3, lincRNA.S746, Rab GDP dissociation inhibitor, rab GDI

Key Links
Genomic Location
Cytogenetic map
30B5-30B5
Sequence location
2L:9,491,176..9,494,876 [-]
Recombination map

2-35

RefSeq locus
NT_033779 REGION:9491176..9494876
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
GDP-dissociation inhibitor activity
Predictions / Assertions
Rab GDP-dissociation inhibitor activity; Rab GTPase binding
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Gdi or the JBrowse view of Dmel\Gdi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Gdi-RA
FBtr0079862
NM_078800
1661
443
Gdi-RB
FBtr0306169
NM_001259024
2421
443
Gdi-RC
FBtr0345433
NM_001298852
2501
443
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Gdi-PA
FBpp0079458
49.9
443
5.41
NP_523524
AAF52777
Gdi-PB
FBpp0297299
49.9
443
5.41
NP_001245953
AFH03627
Gdi-PC
FBpp0311558
49.9
443
5.41
NP_001285781
AHN54295
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

443 aa isoforms: Gdi-PA, Gdi-PB, Gdi-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gdi using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
GDP-dissociation inhibitor activity
inferred from direct assay
(Garrett et al., 1993)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Rab GDP-dissociation inhibitor activity
inferred from biological aspect of ancestor with PANTHER:PTN000209444
(assigned by GO_Central )
(Gaudet et al., 2011)
Rab GTPase binding
inferred from biological aspect of ancestor with PANTHER:PTN000209443
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
neurotransmitter secretion
non-traceable author statement
(Lloyd et al., 2000)
protein transport
inferred from electronic annotation with InterPro:IPR000806
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
small GTPase mediated signal transduction
inferred from electronic annotation with InterPro:IPR018203
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN000209443
(assigned by GO_Central )
(Gaudet et al., 2011)
non-traceable author statement
(Lloyd et al., 2000)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000209443
(assigned by GO_Central )
(Gaudet et al., 2011)
synaptic vesicle
non-traceable author statement
(Lloyd et al., 2000)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
hindgut anlage
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
lateral cord glial cell
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
Bolwig organ
(Fisher et al., 2012)
embryonic antennal sense organ
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic epipharynx
(Fisher et al., 2012)
embryonic esophagus
(Fisher et al., 2012)
embryonic foregut
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic labial sensory complex
(Fisher et al., 2012)
embryonic maxillary sensory complex
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
labral sensory complex
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
midline neuron
(Kearney et al., 2004)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
organism
(Ricard et al., 2001)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gdi in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Gdi
Transgenic constructs containing regulatory region of Gdi
Deletions and Duplications ( 19 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2L)30A-C)
lethal | recessive
lethal - all die before end of larval stage (with GdiL319)
lethal - all die before end of larval stage (with GdiN7-3)
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage (with GdiAK307)
lethal - all die before end of P-stage (with GdiN7-3)
lethal - all die before end of P-stage | recessive
partially lethal, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
partially lethal - majority die, with Scer\GAL4pnr-MD237
Other Phenotypes
Allele
flightless, with Scer\GAL4Mef2.PR
some die during larval stage (with GdiL319)
some die during larval stage (with GdiN7-3)
some die during larval stage | recessive
some die during pharate adult stage (with GdiAK307)
some die during pharate adult stage (with GdiN7-3)
some die during pharate adult stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
embryonic epidermis
embryonic epidermis (with GdiAK307)
embryonic epidermis (with GdiL319)
melanotic mass
mesothoracic tergum, with Scer\GAL4pnr-MD237
pole cell (with GdiAK307)
pole cell (with GdiL319)
pole cell | germline clone
puparium cuticle
sarcomere, with Scer\GAL4Mef2.PR
trichogen cell, with Scer\GAL4pnr-MD237
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GDI1
11 of 15
Yes
Yes
Hsap\GDI2
10 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Gdi1
12 of 15
Yes
Yes
Mmus\Gdi2
10 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Gdi2
9 of 13
Yes
Yes
Rnor\Gdi1
7 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\gdi2
5 of 12
Yes
Yes
Xtro\gdi1
2 of 12
No
Yes
Xtro\LOC101730580
1 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\gdi1
11 of 15
Yes
Yes
Drer\gdi2
10 of 15
No
Yes
Drer\zgc:112334
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\gdi-1
10 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\GDI2
6 of 9
Yes
Yes
Atha\GDI1
5 of 9
No
Yes
Atha\GDI
5 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\GDI1
12 of 15
Yes
Yes
Scer\MRS6
4 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\gdi1
9 of 12
Yes
Yes
Spom\SPBC15C4.03
2 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091907C5 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Gdi
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001583
Drosophila simulans
Dsim\GD22354
Drosophila sechellia
Dsec\GM12441
Drosophila erecta
Dere\GG24025
Drosophila yakuba
Dyak\GE10500
Drosophila ananassae
Dana\GF21994
Drosophila pseudoobscura pseudoobscura
Dpse\GA18172
Drosophila persimilis
Dper\GL25634
Drosophila willistoni
Dwil\GK24240
Drosophila virilis
Dvir\GJ18203
Drosophila mojavensis
Dmoj\GI17638
Drosophila grimshawi
Dgri\GH10775
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915048Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012310
Glossina morsitans
Tsetse fly
Gmor\GMOY010573
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06263
Mayetiola destructor
Hessian fly
Mdes\Mdes004683
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012904
Anopheles darlingi
American malaria mosquito
Adar\ADAC008292
Anopheles gambiae
Malaria mosquito
Agam\AGAP010025
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015309
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0409 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001119
Danaus plexippus
Monarch butterfly
Dple\DPOGS200719-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008970
Apis florea
Little honeybee
Aflo\2417178982
Apis mellifera
Western honey bee
Amel\Gdi
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20438
Bombus terrestris
Buff-tailed bumblebee
Bter\15203392
Linepithema humile
Argentine ant
Lhum\LH18410
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000ae3
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG028068
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02302
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07497
Pediculus humanus
Human body louse
Phum\PHUM614460
Rhodnius prolixus
Kissing bug
Rpro\RPRC003660
Cimex lectularius
Bed bug
Clec\CLEC012314
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009608
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03801
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03WT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008013
Ixodes scapularis
Black-legged tick
Isca\ISCW017892
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69832.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63791.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur35g00670
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_207615
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06PV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gdi1_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Gdi1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001656
Gallus gallus
Domestic chicken
Ggal\GDI2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Rep
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    GdiGD11312
    exacerbates  tauopathy
    modeled by Hsap\MAPTR406W.UAS
    (Butzlaff et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GDI1; GDP dissociation inhibitor 1
    11 of 15
    300104
    GDI2; GDP dissociation inhibitor 2
    10 of 15
    600767
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Gdi - Akap200
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Akr1B
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - AnxB10
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - CG10638
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - EndoGI
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Eno
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - GstE6
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - GstO3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Hsc70Cb
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Mdh2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Moe
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Nrd1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Yoon et al., 2017)
        Gdi - Prx2540-2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Rab1
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014)
        Gdi - Rab10
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Gdi - Rab11
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, pull down
        (Rhee et al., 2014, Ramel et al., 2013)
        Gdi - Rab14
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014)
        Gdi - Rab18
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014, Gillingham et al., 2014)
        Gdi - Rab19
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014)
        Gdi - Rab23
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Çiçek et al., 2016)
        Gdi - Rab3
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Rab30
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014)
        Gdi - Rab35
        experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
        (Rhee et al., 2014, Guruharsha et al., 2011)
        Gdi - Rab5
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, pull down
        (Gillingham et al., 2014, Rhee et al., 2014)
        Gdi - Rab6
        pull down, peptide massfingerprinting
        (Gillingham et al., 2014, Gillingham et al., 2014)
        Gdi - Rab7
        pull down, peptide massfingerprinting, anti tag coimmunoprecipitation, experimental knowledge based
        (Gillingham et al., 2014, Rhee et al., 2014)
        Gdi - RpL38
        anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
        (Rhee et al., 2014)
        Gdi - Stip1
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - Uch
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - capt
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - regucalcin
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - rush
        pull down, anti tag western blot
        (Gailite et al., 2012)
        Gdi - strat
        experimental knowledge based
        (Guruharsha et al., 2011)
        Gdi - yip2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Gdi|rush
        suppressible
        sta
        (Gailite et al., 2012)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Nsf2
        suppressible
        Gdi
        (Laviolette et al., 2005)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-35

        Cytogenetic map
        30B5-30B5
        Sequence location
        2L:9,491,176..9,494,876 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        30B5-30B5
        Limits computationally determined from genome sequence between P{PZ}scat1&P{PZ}numb03235 and P{EP}Oatp30BEP890
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        30B-30B
        (Lloyd et al., 2000, Jakubowski, 1996.4.29, Lewis et al., 1996)
        30A-30A
        (Zahner, 1993.3.3)
        Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
        (Lloyd et al., 2000)
        Experimentally Determined Recombination Data
        Location

        2-35

        (FlyBase, 2016)

        2-30.5

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (16)
        Genomic Clones (12)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (276)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Ricard et al., 2001)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: Gdi l(2)N7-3

          (Ricard et al., 2001)
          Additional comments
          Other Comments

          dsRNA made from templates generated with primers directed against Gdi that is transfected into S2 treated with Listeria monocytogenes reveals Gdi to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape.

          (Cheng et al., 2005)

          One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

          (Inlow and Restifo, 2004)

          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

          (Kiger et al., 2003)

          Area matching Drosophila GDP dissociation inhibitor homologue gene, Acc. No. L03209.

          (Davies, 2001.3.15)

          Gdi can cause the dissociation of S.cerevisiae Sec4 from membranes in a cell free assay and can inhibit dissociation of GDP from Sec4.

          (Garrett et al., 1993)

          Gdi is the Drosophila homolog of the bovine smgp25a GDP dissociation inhibitor.

          (Zahner and Cheney, 1992)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 49 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (14)
          Reported As
          Symbol Synonym
          CG4422
          (Çiçek et al., 2016, Harris et al., 2016, Butzlaff et al., 2015, Hosono et al., 2015, Ramel et al., 2013, Cammarato et al., 2011, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hughes et al., 2008, Molnar et al., 2006, Laviolette et al., 2005, Nakahara et al., 2005, Verstreken and Bellen, 2000.9.4)
          GDI
          (Ramel et al., 2013, Cheney et al., 2007, Domanitskaya et al., 2007, Cheng et al., 2005, Holtzman et al., 2005, Sangji et al., 2005, Marella et al., 2003, Cheney et al., 2001, Ricard et al., 2001, Fernandez et al., 2000, Lloyd et al., 2000, Dong et al., 1999, Jakubowski et al., 1998, Bassett et al., 1997, Jakubowski and Cheney, 1997, Jakubowski et al., 1997, Zahner and Cheney, 1992)
          GdI
          Gdi
          (Transgenic RNAi Project members, 2017-, Yoon et al., 2017, Clandinin and Owens, 2016-, Harris et al., 2016, Butzlaff et al., 2015, Lee et al., 2014, Beckett et al., 2013, Zhang et al., 2013, Fischer et al., 2012, Gailite et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ma et al., 2012, Reis et al., 2010, Perkins et al., 2009.8.10, Font-Burgada et al., 2008, Buszczak et al., 2007, Stuart et al., 2007, Zhang et al., 2007, Altenhein et al., 2006, Molnar et al., 2006, Laviolette et al., 2005)
          N7-3
          (Ricard et al., 2001)
          dGDI
          (Garrett and Novick, 1995, Garrett et al., 1993, Zahner, 1993.3.3, Zahner and Cheney, 1993, Zahner and Cheney, 1992)
          gdi
          (Scholz et al., 2019)
          l(2)N7-3
          (Bloomington Drosophila Stock Center, 1997.12.5, Lane and Kalderon, 1993)
          lincRNA.S746
          (FlyBase Genome Annotators, 2014, Young et al., 2012)
          rab GDI
          (Jakubowski et al., 1999, Lewis et al., 1996)
          Name Synonyms
          GDP dissociation inhibitor
          (Cammarato et al., 2011)
          Gdi-related
          (Zhang et al., 2004)
          Rab GDP dissociation inhibitor
          (Gailite et al., 2012, Cheney et al., 2007)
          rab GDP dissociation inhibitor
          (Fernandez et al., 2000)
          Secondary FlyBase IDs
          • FBgn0010224
          • FBgn0014258
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (123)