• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Gdi

General Information
Symbol	Dmel\Gdi	Species	D. melanogaster
Name	GDP dissociation inhibitor	Annotation symbol	CG4422
Feature type	protein_coding_gene	FlyBase ID	FBgn0004868
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	dGDI, rab GDI, l(2)N7-3
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	30B5-30B5	Sequence location	2L:9,491,176..9,494,796 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene GDP dissociation inhibitor is referred to in FlyBase by the symbol Dmel\Gdi (CG4422, FBgn0004868). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: GDP-dissociation inhibitor activity. It is reported to be involved in the biological process: neurotransmitter secretion; vesicle-mediated transport. 26 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; puparium; pole cell; embryonic epidermis; mesothoracic tergum; melanotic mass. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: GDP dissociation inhibitor; Rab GDI protein. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1641129_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Gdi. Gene sequence location is 2L:9491176..9494796.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30B5-30B5   Limits computationally determined from genome sequence between P{PZ}scat1&P{PZ}numb03235 and P{EP}Oatp30BEP890
Experimentally Determined Cytological Location
Cytogenetic map Notes References 30A-30A     (Zahner, 1993.3.3) 30B-30B     (Jakubowski, 1996.4.29) 30B-30B     (Lewis et al., 1996) 30B-30B   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gdi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gdi-RA FBtr0079862  NM_078800   1661   443 Gdi-RB FBtr0306169  NM_001259024   2421   443
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gdi-PA   FBpp0079458   49.9   443   5.41     NP_523524   AAF52777 Gdi-PB   FBpp0297299   49.9   443   5.41     NP_001245953   AFH03627
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • GDP dissociation inhibitor (IPR018203) Rab GDI protein (IPR000806)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438650   AA440359   AA694998   AA694999   AA695027   AA695723   AA697543   AA820936   AA938841   AA950868   AE014134 AAF52777   AE014134 AFH03627   AI064209   AI134813   AI238231   AI238693   AI238726   AI239177   AI259181   AI259568   AI292658   AI293904   AI387092   AI388129   AI511734   AI515084   AI516421   AI517360   AI530965   AI531052   AI534241   AI546334   AW943868   AX093884   AY069697 AAL39842   BF485664   BF486012   BF489175   BF493176   BF493184   BF495356   BF506387   BG634454   BG636601   BG637293   BG637468   BI168466   BI170726   BI235128   BI236127   BI351973   BI352099   BI353057   BI356422   BI358421   BI483334   BI575545   BI575615   BI577538   BI578573   BI580158   BI584757   BI628400   BI629034   BI636442   BI639080   BI641641   BP546907   BP552328   BP552329   BT003563 AAO39567   BX011756   BX019963   BX023401   BX053859   BZ665520   CA803214   CK131953   CK657873   CK660734   CO155320   CO156924   CO194338   CO267578   CO272054   CO272395   CO272467   CO277014   CO278520   CO278821   CO283977   CO287900   CO288903   CO295044   CO298086   CO304665   CO309029   CO310798   CO315127   CO318963   CO319609   CO322724   CO324238   CO324565   CO324582   CO325085   CO327311   CO327558   CO327743   CO328486   CO330808   CO333155   CO341239   CZ470467   CZ471023   CZ478725   EC058712   EC063352   EC064061   EC066965   EC067970   EC068604   EC070086   EC071788   EC077043   EC077756   EC079082   EC080363   EC083113   EC086231   EC088613   EC091127   EC197427   EC197898   EC198672   EC203278   EC211563   EC212176   EC212234   EC212759   EC214360   EC223570   EC225156   EC226106   EC227364   EC227937   EC231674   EC232158   EC237787   EC244361   EC245071   EC251220   EC255372   EC255760   EC256941   EC261084   EC264917   EV577451   EV579560   EV581580   EV586224   GH747776   GH747907   GH752739   GH753352   GH753439   GH754557   GH754940   GH758356   GH759740   GH760734   GH770242   GH772402   GH776890   GH778407   GH778980   GH781715   GH783640   GH784431   GH785873   GH787898   GH788108   GH788741   GH789033   GH790368   GH791321   GH791502   GH791589   GH791726   GH792301   GH792883   GH793710   GH794280   GH795477   GH797148   GH797254   GH800038   GH800615   GH805105   GH805319   GH805770   GH805859   GH806121   GH807240   GH808066   GH808099   GH808189   GH809149   GH809250   GH809703   GH809927   GH810005   GH810563   GH811577   GH812620   GH813177   GH814079   GH815540   GH816405   GH818439   GH818889   GH823112   GH823717   GH826434   GH828637   GH828912   GH830844   GH831586   GH831772   GH831796   GH831806   GH831810   GH831846   GH832216   GH832728   GH833414   GH834712   GH834837   GH837737   GH838292   GH839327   GH839453   GH840046   GH841835   GH846223   GH851427   GH852227   GH854516   GH855619   GH855791   GH855833   GH856745   GH857316   GH857804   GH857941   GH857962   GH859483   GH860221   GH860989   GH861554   GH864501   GH864724   GH865089   GH868166   GH869294   GH869416   GH873842   GH875204   GH877063   GH878214   GH878245   GH879524   GH879720   GH879803   GH880212   GH881423   GH882509   GH883482   GH884225   GH884312   GH884769   GH886144   GH887050   GH891053   GH892678   GH895738   GH896040   GH896605   GH896919   GH899189   GH899555   GH899879   GH899881   GH900641   GH902242   GH902369   GH902968   GH904665   GH910457   GH911191   GH911415   GH912309   GH915454   GH919699   GH920804   GH924561   GH925278   GH925408   GH925793   GH926967   GH927379   GH928807   GH930919   GH931996   GH932322   GH933891   GH934060   GH934485   GH934572   GH935218   L03209 AAA28567
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VLB7 Q24349
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   hindgut anlage   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium inclusive hindgut primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) embryonic antennal sense organ   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic epipharynx   (Fisher et al., 2012) embryonic esophagus   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic hypopharynx   (Fisher et al., 2012) embryonic labial sensory complex   (Fisher et al., 2012) embryonic maxillary sensory complex   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) labral sensory complex   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference larval stage   organism   (Ricard et al., 2001)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    887.1 Larval Midgut    1425.3 Larval Hindgut    1283.3 Larval Malpighian Tubules    2557.6 Larval Fat Body    1823.8 Larval Salivary Gland    2357.5 Larval Trachea    1810.5 Larval Carcass    1011.825 Adult Head    627.8 Adult Eye    1127 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    674.9 Adult Crop    915.8 Adult Midgut    1138.3 Adult Hindgut    1079.1 Adult Malpighian Tubules    577.4 Adult Fat Body    1034.1 Adult Salivary Gland    1102.1 Adult Heart    1859.5 Adult VirginFemale Spermatheca    1296.2 Adult InseminatedFemale Spermatheca    1425.5 Adult Ovary    1061.2 Adult Testis    384.3 Adult Male Accessory Gland    1419.1 Adult Carcass    791.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (887.1) Larval Midgut  (1425.3) Larval Hindgut  (1283.3) Larval Malpighian Tubules  (2557.6) Larval Fat Body  (1823.8) Larval Salivary Gland  (2357.5) Larval Trachea  (1810.5) Larval Carcass  (1011.825) Adult Head  (627.8) Adult Eye  (1127) Adult Brain  (871.4) Adult Thoracic-Abdominal Ganglion  (674.9) Adult Crop  (915.8) Adult Midgut  (1138.3) Adult Hindgut  (1079.1) Adult Malpighian Tubules  (577.4) Adult Fat Body  (1034.1) Adult Salivary Gland  (1102.1) Adult Heart  (1859.5) Adult VirginFemale Spermatheca  (1296.2) Adult InseminatedFemale Spermatheca  (1425.5) Adult Ovary  (1061.2) Adult Testis    384.3 Adult Male Accessory Gland  (1419.1) Adult Carcass  (791.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    887.1 Larval Midgut  (1425.3) Larval Hindgut  (1283.3) Larval Malpighian Tubules  (2557.6) Larval Fat Body  (1823.8) Larval Salivary Gland  (2357.5) Larval Trachea  (1810.5) Larval Carcass  1011.825 Adult Head    627.8 Adult Eye  (1127) Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    674.9 Adult Crop    915.8 Adult Midgut  (1138.3) Adult Hindgut  (1079.1) Adult Malpighian Tubules    577.4 Adult Fat Body  1034.1 Adult Salivary Gland  (1102.1) Adult Heart  (1859.5) Adult VirginFemale Spermatheca  (1296.2) Adult InseminatedFemale Spermatheca  (1425.5) Adult Ovary  1061.2 Adult Testis    384.3 Adult Male Accessory Gland  (1419.1) Adult Carcass    791.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    887.1 Larval Midgut    1425.3 Larval Hindgut    1283.3 Larval Malpighian Tubules    2557.6 Larval Fat Body    1823.8 Larval Salivary Gland    2357.5 Larval Trachea    1810.5 Larval Carcass    1011.825 Adult Head    627.8 Adult Eye    1127 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    674.9 Adult Crop    915.8 Adult Midgut    1138.3 Adult Hindgut    1079.1 Adult Malpighian Tubules    577.4 Adult Fat Body    1034.1 Adult Salivary Gland    1102.1 Adult Heart    1859.5 Adult VirginFemale Spermatheca    1296.2 Adult InseminatedFemale Spermatheca    1425.5 Adult Ovary    1061.2 Adult Testis    384.3 Adult Male Accessory Gland    1419.1 Adult Carcass    791.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    887.1 Larval Midgut    1425.3 Larval Hindgut    1283.3 Larval Malpighian Tubules    2557.6 Larval Fat Body    1823.8 Larval Salivary Gland    2357.5 Larval Trachea    1810.5 Larval Carcass    1011.825 Adult Head    627.8 Adult Eye    1127 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    674.9 Adult Crop    915.8 Adult Midgut    1138.3 Adult Hindgut    1079.1 Adult Malpighian Tubules    577.4 Adult Fat Body    1034.1 Adult Salivary Gland    1102.1 Adult Heart    1859.5 Adult VirginFemale Spermatheca    1296.2 Adult InseminatedFemale Spermatheca    1425.5 Adult Ovary    1061.2 Adult Testis    384.3 Adult Male Accessory Gland    1419.1 Adult Carcass    791.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (887.1) Larval Midgut  (1425.3) Larval Hindgut  (1283.3) Larval Malpighian Tubules  (2557.6) Larval Fat Body  (1823.8) Larval Salivary Gland  (2357.5) Larval Trachea  (1810.5) Larval Carcass  (1011.825) Adult Head  627.8 Adult Eye  (1127) Adult Brain  (871.4) Adult Thoracic-Abdominal Ganglion  674.9 Adult Crop  (915.8) Adult Midgut  (1138.3) Adult Hindgut  (1079.1) Adult Malpighian Tubules  577.4 Adult Fat Body  (1034.1) Adult Salivary Gland  (1102.1) Adult Heart  (1859.5) Adult VirginFemale Spermatheca  (1296.2) Adult InseminatedFemale Spermatheca  (1425.5) Adult Ovary  (1061.2) Adult Testis    384.3 Adult Male Accessory Gland  (1419.1) Adult Carcass  791.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    887.1 Larval Midgut  1425.3 Larval Hindgut  1283.3 Larval Malpighian Tubules  (2557.6) Larval Fat Body  (1823.8) Larval Salivary Gland  (2357.5) Larval Trachea  (1810.5) Larval Carcass  1011.825 Adult Head    627.8 Adult Eye  1127 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    674.9 Adult Crop    915.8 Adult Midgut  1138.3 Adult Hindgut  1079.1 Adult Malpighian Tubules    577.4 Adult Fat Body  1034.1 Adult Salivary Gland  1102.1 Adult Heart  (1859.5) Adult VirginFemale Spermatheca  1296.2 Adult InseminatedFemale Spermatheca  1425.5 Adult Ovary  1061.2 Adult Testis    384.3 Adult Male Accessory Gland  1419.1 Adult Carcass    791.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    887.1 Larval Midgut    1425.3 Larval Hindgut    1283.3 Larval Malpighian Tubules    2557.6 Larval Fat Body    1823.8 Larval Salivary Gland    2357.5 Larval Trachea    1810.5 Larval Carcass    1011.825 Adult Head    627.8 Adult Eye    1127 Adult Brain    871.4 Adult Thoracic-Abdominal Ganglion    674.9 Adult Crop    915.8 Adult Midgut    1138.3 Adult Hindgut    1079.1 Adult Malpighian Tubules    577.4 Adult Fat Body    1034.1 Adult Salivary Gland    1102.1 Adult Heart    1859.5 Adult VirginFemale Spermatheca    1296.2 Adult InseminatedFemale Spermatheca    1425.5 Adult Ovary    1061.2 Adult Testis    384.3 Adult Male Accessory Gland    1419.1 Adult Carcass    791.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    627.8   NA  Eye    1127   NA  Brain    871.4   887.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    674.9   NA  Crop    915.8   1425.3  Midgut    1138.3   1283.3  Hindgut    1079.1   2557.6  Malpighian Tubules    577.4   1823.8  Fat Body    1034.1   2357.5  Salivary Gland    1102.1   NA  Heart    1859.5   1810.5  Trachea    NA   NA  VirginFemale Spermatheca    1296.2   NA  InseminatedFemale Spermatheca    1425.5   NA  Ovary    1061.2   NA  Testis    384.3   NA  Male Accessory Gland    1419.1   1011.825  Carcass    791.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    129 central nervous system, larvae L3    254 central nervous system, pupae P8    258 head, virgin 1-day female    98 head, virgin 4-day female    88 head, virgin 20-day female    72 head, mated 1-day female    92 head, mated 4-day female    71 head, mated 20-day female    69 head, mated 1-day male    102 head, mated 4-day male    111 head, mated 20-day male    107 salivary gland, larvae L3 wandering    98 salivary gland, white prepupae    340 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    132 digestive system, 4-day adult    102 digestive system, 20-day adult    96 fat body, larvae L3 wandering    124 fat body, white prepupae    191 fat body, pupae P8    229 carcass, larvae L3 wandering    169 carcass, 1-day adult    68 carcass, 4-day adult    81 carcass, 20-day adult    79 ovary, virgin 4-day female    191 ovary, mated 4-day female    158 testis, mated 4-day male    99 accessory gland, mated 4-day male    115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (129) central nervous system, larvae L3  (254) central nervous system, pupae P8  (258) head, virgin 1-day female  (98) head, virgin 4-day female  (88) head, virgin 20-day female  (72) head, mated 1-day female  (92) head, mated 4-day female  (71) head, mated 20-day female  (69) head, mated 1-day male  (102) head, mated 4-day male  (111) head, mated 20-day male  (107) salivary gland, larvae L3 wandering  (98) salivary gland, white prepupae  (340) digestive system, larvae L3 wandering  (196) digestive system, 1-day adult  (132) digestive system, 4-day adult  (102) digestive system, 20-day adult  (96) fat body, larvae L3 wandering  (124) fat body, white prepupae  (191) fat body, pupae P8  (229) carcass, larvae L3 wandering  (169) carcass, 1-day adult  (68) carcass, 4-day adult  (81) carcass, 20-day adult  (79) ovary, virgin 4-day female  (191) ovary, mated 4-day female  (158) testis, mated 4-day male  (99) accessory gland, mated 4-day male  (115) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (129) central nervous system, larvae L3  (254) central nervous system, pupae P8  (258) head, virgin 1-day female    98 head, virgin 4-day female    88 head, virgin 20-day female    72 head, mated 1-day female    92 head, mated 4-day female    71 head, mated 20-day female    69 head, mated 1-day male  102 head, mated 4-day male  (111) head, mated 20-day male  107 salivary gland, larvae L3 wandering    98 salivary gland, white prepupae  (340) digestive system, larvae L3 wandering  (196) digestive system, 1-day adult  (132) digestive system, 4-day adult  102 digestive system, 20-day adult    96 fat body, larvae L3 wandering  (124) fat body, white prepupae  (191) fat body, pupae P8  (229) carcass, larvae L3 wandering  (169) carcass, 1-day adult    68 carcass, 4-day adult    81 carcass, 20-day adult    79 ovary, virgin 4-day female  (191) ovary, mated 4-day female  (158) testis, mated 4-day male    99 accessory gland, mated 4-day male  (115) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    129 central nervous system, larvae L3    254 central nervous system, pupae P8    258 head, virgin 1-day female    98 head, virgin 4-day female    88 head, virgin 20-day female    72 head, mated 1-day female    92 head, mated 4-day female    71 head, mated 20-day female    69 head, mated 1-day male    102 head, mated 4-day male    111 head, mated 20-day male    107 salivary gland, larvae L3 wandering    98 salivary gland, white prepupae    340 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    132 digestive system, 4-day adult    102 digestive system, 20-day adult    96 fat body, larvae L3 wandering    124 fat body, white prepupae    191 fat body, pupae P8    229 carcass, larvae L3 wandering    169 carcass, 1-day adult    68 carcass, 4-day adult    81 carcass, 20-day adult    79 ovary, virgin 4-day female    191 ovary, mated 4-day female    158 testis, mated 4-day male    99 accessory gland, mated 4-day male    115 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    129 central nervous system, larvae L3    254 central nervous system, pupae P8    258 head, virgin 1-day female    98 head, virgin 4-day female    88 head, virgin 20-day female    72 head, mated 1-day female    92 head, mated 4-day female    71 head, mated 20-day female    69 head, mated 1-day male    102 head, mated 4-day male    111 head, mated 20-day male    107 salivary gland, larvae L3 wandering    98 salivary gland, white prepupae    340 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    132 digestive system, 4-day adult    102 digestive system, 20-day adult    96 fat body, larvae L3 wandering    124 fat body, white prepupae    191 fat body, pupae P8    229 carcass, larvae L3 wandering    169 carcass, 1-day adult    68 carcass, 4-day adult    81 carcass, 20-day adult    79 ovary, virgin 4-day female    191 ovary, mated 4-day female    158 testis, mated 4-day male    99 accessory gland, mated 4-day male    115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (129) central nervous system, larvae L3  (254) central nervous system, pupae P8  (258) head, virgin 1-day female  (98) head, virgin 4-day female  (88) head, virgin 20-day female  (72) head, mated 1-day female  (92) head, mated 4-day female  (71) head, mated 20-day female  (69) head, mated 1-day male  (102) head, mated 4-day male  (111) head, mated 20-day male  (107) salivary gland, larvae L3 wandering  (98) salivary gland, white prepupae  (340) digestive system, larvae L3 wandering  (196) digestive system, 1-day adult  (132) digestive system, 4-day adult  (102) digestive system, 20-day adult  (96) fat body, larvae L3 wandering  (124) fat body, white prepupae  (191) fat body, pupae P8  (229) carcass, larvae L3 wandering  (169) carcass, 1-day adult  (68) carcass, 4-day adult  (81) carcass, 20-day adult  (79) ovary, virgin 4-day female  (191) ovary, mated 4-day female  (158) testis, mated 4-day male  (99) accessory gland, mated 4-day male  (115) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  129 central nervous system, larvae L3  (254) central nervous system, pupae P8  (258) head, virgin 1-day female    98 head, virgin 4-day female    88 head, virgin 20-day female    72 head, mated 1-day female    92 head, mated 4-day female    71 head, mated 20-day female    69 head, mated 1-day male  102 head, mated 4-day male  111 head, mated 20-day male  107 salivary gland, larvae L3 wandering    98 salivary gland, white prepupae  (340) digestive system, larvae L3 wandering  (196) digestive system, 1-day adult  132 digestive system, 4-day adult  102 digestive system, 20-day adult    96 fat body, larvae L3 wandering  124 fat body, white prepupae  (191) fat body, pupae P8  (229) carcass, larvae L3 wandering  (169) carcass, 1-day adult    68 carcass, 4-day adult    81 carcass, 20-day adult    79 ovary, virgin 4-day female  (191) ovary, mated 4-day female  (158) testis, mated 4-day male    99 accessory gland, mated 4-day male  115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    129 central nervous system, larvae L3    254 central nervous system, pupae P8    258 head, virgin 1-day female    98 head, virgin 4-day female    88 head, virgin 20-day female    72 head, mated 1-day female    92 head, mated 4-day female    71 head, mated 20-day female    69 head, mated 1-day male    102 head, mated 4-day male    111 head, mated 20-day male    107 salivary gland, larvae L3 wandering    98 salivary gland, white prepupae    340 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    132 digestive system, 4-day adult    102 digestive system, 20-day adult    96 fat body, larvae L3 wandering    124 fat body, white prepupae    191 fat body, pupae P8    229 carcass, larvae L3 wandering    169 carcass, 1-day adult    68 carcass, 4-day adult    81 carcass, 20-day adult    79 ovary, virgin 4-day female    191 ovary, mated 4-day female    158 testis, mated 4-day male    99 accessory gland, mated 4-day male    115 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    169 embryo 02-04hr    37 embryo 04-06hr    72 embryo 06-08hr    110 embryo 08-10hr    113 embryo 10-12hr    173 embryo 12-14hr    117 embryo 14-16hr    116 embryo 16-18hr    85 embryo 18-20hr    74 embryo 20-22hr    63 embryo 22-24hr    66 larva L1    86 larva L2    129 larva L3 12hr old    100 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    178 larva L3 puffstage 7-9    203 white prepupae new    246 white prepupae 12hr    170 white prepupae 24hr    183 pupae 2d postWPP    139 pupae 3d postWPP    80 pupae 4d postWPP    56 adult male 01day    87 adult male 05day    89 adult male 30day    76 adult female 01day    118 adult female 05day    157 adult female 30day    155 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (169) embryo 02-04hr  (37) embryo 04-06hr  (72) embryo 06-08hr  (110) embryo 08-10hr  (113) embryo 10-12hr  (173) embryo 12-14hr  (117) embryo 14-16hr  (116) embryo 16-18hr  (85) embryo 18-20hr  (74) embryo 20-22hr  (63) embryo 22-24hr  (66) larva L1  (86) larva L2  (129) larva L3 12hr old  (100) larva L3 puffstage 1-2  (139) larva L3 puffstage 3-6  (178) larva L3 puffstage 7-9  (203) white prepupae new  (246) white prepupae 12hr  (170) white prepupae 24hr  (183) pupae 2d postWPP  (139) pupae 3d postWPP  (80) pupae 4d postWPP  (56) adult male 01day  (87) adult male 05day  (89) adult male 30day  (76) adult female 01day  (118) adult female 05day  (157) adult female 30day  (155) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (169) embryo 02-04hr    37 embryo 04-06hr    72 embryo 06-08hr  (110) embryo 08-10hr  (113) embryo 10-12hr  (173) embryo 12-14hr  (117) embryo 14-16hr  (116) embryo 16-18hr    85 embryo 18-20hr    74 embryo 20-22hr    63 embryo 22-24hr    66 larva L1    86 larva L2  (129) larva L3 12hr old    100 larva L3 puffstage 1-2  (139) larva L3 puffstage 3-6  (178) larva L3 puffstage 7-9  (203) white prepupae new  (246) white prepupae 12hr  (170) white prepupae 24hr  (183) pupae 2d postWPP  (139) pupae 3d postWPP    80 pupae 4d postWPP    56 adult male 01day    87 adult male 05day    89 adult male 30day    76 adult female 01day  (118) adult female 05day  (157) adult female 30day  (155) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    169 embryo 02-04hr    37 embryo 04-06hr    72 embryo 06-08hr    110 embryo 08-10hr    113 embryo 10-12hr    173 embryo 12-14hr    117 embryo 14-16hr    116 embryo 16-18hr    85 embryo 18-20hr    74 embryo 20-22hr    63 embryo 22-24hr    66 larva L1    86 larva L2    129 larva L3 12hr old    100 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    178 larva L3 puffstage 7-9    203 white prepupae new    246 white prepupae 12hr    170 white prepupae 24hr    183 pupae 2d postWPP    139 pupae 3d postWPP    80 pupae 4d postWPP    56 adult male 01day    87 adult male 05day    89 adult male 30day    76 adult female 01day    118 adult female 05day    157 adult female 30day    155 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    169 embryo 02-04hr    37 embryo 04-06hr    72 embryo 06-08hr    110 embryo 08-10hr    113 embryo 10-12hr    173 embryo 12-14hr    117 embryo 14-16hr    116 embryo 16-18hr    85 embryo 18-20hr    74 embryo 20-22hr    63 embryo 22-24hr    66 larva L1    86 larva L2    129 larva L3 12hr old    100 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    178 larva L3 puffstage 7-9    203 white prepupae new    246 white prepupae 12hr    170 white prepupae 24hr    183 pupae 2d postWPP    139 pupae 3d postWPP    80 pupae 4d postWPP    56 adult male 01day    87 adult male 05day    89 adult male 30day    76 adult female 01day    118 adult female 05day    157 adult female 30day    155 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (169) embryo 02-04hr  (37) embryo 04-06hr  (72) embryo 06-08hr  (110) embryo 08-10hr  (113) embryo 10-12hr  (173) embryo 12-14hr  (117) embryo 14-16hr  (116) embryo 16-18hr  (85) embryo 18-20hr  (74) embryo 20-22hr  (63) embryo 22-24hr  (66) larva L1  (86) larva L2  (129) larva L3 12hr old  (100) larva L3 puffstage 1-2  (139) larva L3 puffstage 3-6  (178) larva L3 puffstage 7-9  (203) white prepupae new  (246) white prepupae 12hr  (170) white prepupae 24hr  (183) pupae 2d postWPP  (139) pupae 3d postWPP  (80) pupae 4d postWPP  (56) adult male 01day  (87) adult male 05day  (89) adult male 30day  (76) adult female 01day  (118) adult female 05day  (157) adult female 30day  (155) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (169) embryo 02-04hr    37 embryo 04-06hr    72 embryo 06-08hr  110 embryo 08-10hr  113 embryo 10-12hr  (173) embryo 12-14hr  117 embryo 14-16hr  116 embryo 16-18hr    85 embryo 18-20hr    74 embryo 20-22hr    63 embryo 22-24hr    66 larva L1    86 larva L2  129 larva L3 12hr old    100 larva L3 puffstage 1-2  139 larva L3 puffstage 3-6  (178) larva L3 puffstage 7-9  (203) white prepupae new  (246) white prepupae 12hr  (170) white prepupae 24hr  (183) pupae 2d postWPP  139 pupae 3d postWPP    80 pupae 4d postWPP    56 adult male 01day    87 adult male 05day    89 adult male 30day    76 adult female 01day  118 adult female 05day  (157) adult female 30day  (155) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    169 embryo 02-04hr    37 embryo 04-06hr    72 embryo 06-08hr    110 embryo 08-10hr    113 embryo 10-12hr    173 embryo 12-14hr    117 embryo 14-16hr    116 embryo 16-18hr    85 embryo 18-20hr    74 embryo 20-22hr    63 embryo 22-24hr    66 larva L1    86 larva L2    129 larva L3 12hr old    100 larva L3 puffstage 1-2    139 larva L3 puffstage 3-6    178 larva L3 puffstage 7-9    203 white prepupae new    246 white prepupae 12hr    170 white prepupae 24hr    183 pupae 2d postWPP    139 pupae 3d postWPP    80 pupae 4d postWPP    56 adult male 01day    87 adult male 05day    89 adult male 30day    76 adult female 01day    118 adult female 05day    157 adult female 30day    155 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    185 Schneider line 2 Sg4    353 embryonic 1182-4H    145 embryonic GM2    98 embryonic Kc167    52 embryonic S1    209 embryonic S3    200 leg disc CME L1    239 wing disc CME-W2    234 wing disc ML-DmD8    178 wing disc ML-DmD9    185 wing disc ML-DmD16-c3    162 wing disc ML-DmD21    437 wing disc ML-DmD32    179 haltere disc ML-DmD17-c3    447 eye-antennal disc ML-DmD11    213 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    266 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    240 tumorous blood cells mbn2    161 ovary fGS/OSS    90 ovary OSC    199 ovary OSS    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (185) Schneider line 2 Sg4  (353) embryonic 1182-4H  (145) embryonic GM2  (98) embryonic Kc167  (52) embryonic S1  (209) embryonic S3  (200) leg disc CME L1  (239) wing disc CME-W2  (234) wing disc ML-DmD8  (178) wing disc ML-DmD9  (185) wing disc ML-DmD16-c3  (162) wing disc ML-DmD21  (437) wing disc ML-DmD32  (179) haltere disc ML-DmD17-c3  (447) eye-antennal disc ML-DmD11  (213) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (266) CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2  (240) tumorous blood cells mbn2  (161) ovary fGS/OSS  (90) ovary OSC  (199) ovary OSS  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (185) Schneider line 2 Sg4  (353) embryonic 1182-4H  (145) embryonic GM2    98 embryonic Kc167    52 embryonic S1  (209) embryonic S3  (200) leg disc CME L1  (239) wing disc CME-W2  (234) wing disc ML-DmD8  (178) wing disc ML-DmD9  (185) wing disc ML-DmD16-c3  (162) wing disc ML-DmD21  (437) wing disc ML-DmD32  (179) haltere disc ML-DmD17-c3  (447) eye-antennal disc ML-DmD11  (213) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (266) CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2  (240) tumorous blood cells mbn2  (161) ovary fGS/OSS    90 ovary OSC  (199) ovary OSS    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    185 Schneider line 2 Sg4    353 embryonic 1182-4H    145 embryonic GM2    98 embryonic Kc167    52 embryonic S1    209 embryonic S3    200 leg disc CME L1    239 wing disc CME-W2    234 wing disc ML-DmD8    178 wing disc ML-DmD9    185 wing disc ML-DmD16-c3    162 wing disc ML-DmD21    437 wing disc ML-DmD32    179 haltere disc ML-DmD17-c3    447 eye-antennal disc ML-DmD11    213 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    266 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    240 tumorous blood cells mbn2    161 ovary fGS/OSS    90 ovary OSC    199 ovary OSS    71 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    185 Schneider line 2 Sg4    353 embryonic 1182-4H    145 embryonic GM2    98 embryonic Kc167    52 embryonic S1    209 embryonic S3    200 leg disc CME L1    239 wing disc CME-W2    234 wing disc ML-DmD8    178 wing disc ML-DmD9    185 wing disc ML-DmD16-c3    162 wing disc ML-DmD21    437 wing disc ML-DmD32    179 haltere disc ML-DmD17-c3    447 eye-antennal disc ML-DmD11    213 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    266 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    240 tumorous blood cells mbn2    161 ovary fGS/OSS    90 ovary OSC    199 ovary OSS    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (185) Schneider line 2 Sg4  (353) embryonic 1182-4H  (145) embryonic GM2  (98) embryonic Kc167  (52) embryonic S1  (209) embryonic S3  (200) leg disc CME L1  (239) wing disc CME-W2  (234) wing disc ML-DmD8  (178) wing disc ML-DmD9  (185) wing disc ML-DmD16-c3  (162) wing disc ML-DmD21  (437) wing disc ML-DmD32  (179) haltere disc ML-DmD17-c3  (447) eye-antennal disc ML-DmD11  (213) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (266) CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2  (240) tumorous blood cells mbn2  (161) ovary fGS/OSS  (90) ovary OSC  (199) ovary OSS  (71) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (185) Schneider line 2 Sg4  (353) embryonic 1182-4H  (145) embryonic GM2    98 embryonic Kc167    52 embryonic S1  (209) embryonic S3  (200) leg disc CME L1  (239) wing disc CME-W2  (234) wing disc ML-DmD8  (178) wing disc ML-DmD9  (185) wing disc ML-DmD16-c3  (162) wing disc ML-DmD21  (437) wing disc ML-DmD32  (179) haltere disc ML-DmD17-c3  (447) eye-antennal disc ML-DmD11  (213) antennal disc ML-DmD20-c5  (261) mixed discs ML-DmD4-c1  (266) CNS ML-DmBG1-c1  (151) CNS ML-DmBG2-c2  (240) tumorous blood cells mbn2  (161) ovary fGS/OSS    90 ovary OSC  (199) ovary OSS    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    185 Schneider line 2 Sg4    353 embryonic 1182-4H    145 embryonic GM2    98 embryonic Kc167    52 embryonic S1    209 embryonic S3    200 leg disc CME L1    239 wing disc CME-W2    234 wing disc ML-DmD8    178 wing disc ML-DmD9    185 wing disc ML-DmD16-c3    162 wing disc ML-DmD21    437 wing disc ML-DmD32    179 haltere disc ML-DmD17-c3    447 eye-antennal disc ML-DmD11    213 antennal disc ML-DmD20-c5    261 mixed discs ML-DmD4-c1    266 CNS ML-DmBG1-c1    151 CNS ML-DmBG2-c2    240 tumorous blood cells mbn2    161 ovary fGS/OSS    90 ovary OSC    199 ovary OSS    71 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    51 heat shock, 4-day adult    95 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    102 Cadmium 100 mM 48 hrs, 4-day adult    125 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    115 Ethanol 2.5% 3 hrs, larvae L3    102 Ethanol 5% 3 hrs, larvae L3    123 Ethanol 10% 3 hrs, larvae L3    100 Caffeine 1.5 mg/ml 4 hrs, larvae L3    115 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    122 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    107 Paraquat 10 mM 48 hrs, 4-day adult    85 Rotenone 2 μg 12 hrs, larvae L3    128 Rotenone 8 μg 12 hrs, larvae L3    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (66) cold shock, 4-day adult  (51) heat shock, 4-day adult  (95) Cadmium 50 mM 6 hrs, larvae L3  (136) Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  (102) Cadmium 100 mM 48 hrs, 4-day adult  (125) Copper 0.5 mM 12 hrs, larvae L3  (46) Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3  (55) Zinc 4.5 mM 48 hrs, 4-day adult  (115) Ethanol 2.5% 3 hrs, larvae L3  (102) Ethanol 5% 3 hrs, larvae L3  (123) Ethanol 10% 3 hrs, larvae L3  (100) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (115) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (122) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (107) Paraquat 10 mM 48 hrs, 4-day adult  (85) Rotenone 2 μg 12 hrs, larvae L3  (128) Rotenone 8 μg 12 hrs, larvae L3  (101) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    51 heat shock, 4-day adult    95 Cadmium 50 mM 6 hrs, larvae L3  (136) Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  102 Cadmium 100 mM 48 hrs, 4-day adult  (125) Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult  (115) Ethanol 2.5% 3 hrs, larvae L3  102 Ethanol 5% 3 hrs, larvae L3  (123) Ethanol 10% 3 hrs, larvae L3    100 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (115) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (122) Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult  107 Paraquat 10 mM 48 hrs, 4-day adult    85 Rotenone 2 μg 12 hrs, larvae L3  (128) Rotenone 8 μg 12 hrs, larvae L3  101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    51 heat shock, 4-day adult    95 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    102 Cadmium 100 mM 48 hrs, 4-day adult    125 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    115 Ethanol 2.5% 3 hrs, larvae L3    102 Ethanol 5% 3 hrs, larvae L3    123 Ethanol 10% 3 hrs, larvae L3    100 Caffeine 1.5 mg/ml 4 hrs, larvae L3    115 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    122 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    107 Paraquat 10 mM 48 hrs, 4-day adult    85 Rotenone 2 μg 12 hrs, larvae L3    128 Rotenone 8 μg 12 hrs, larvae L3    101 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    51 heat shock, 4-day adult    95 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    102 Cadmium 100 mM 48 hrs, 4-day adult    125 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    115 Ethanol 2.5% 3 hrs, larvae L3    102 Ethanol 5% 3 hrs, larvae L3    123 Ethanol 10% 3 hrs, larvae L3    100 Caffeine 1.5 mg/ml 4 hrs, larvae L3    115 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    122 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    107 Paraquat 10 mM 48 hrs, 4-day adult    85 Rotenone 2 μg 12 hrs, larvae L3    128 Rotenone 8 μg 12 hrs, larvae L3    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (66) cold shock, 4-day adult  (51) heat shock, 4-day adult  (95) Cadmium 50 mM 6 hrs, larvae L3  (136) Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  (102) Cadmium 100 mM 48 hrs, 4-day adult  (125) Copper 0.5 mM 12 hrs, larvae L3  (46) Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3  (55) Zinc 4.5 mM 48 hrs, 4-day adult  (115) Ethanol 2.5% 3 hrs, larvae L3  (102) Ethanol 5% 3 hrs, larvae L3  (123) Ethanol 10% 3 hrs, larvae L3  (100) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (115) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (122) Caffeine 25 mg/ml 48 hrs, 4-day adult  (61) Paraquat 5 mM 48 hrs, 4-day adult  (107) Paraquat 10 mM 48 hrs, 4-day adult  (85) Rotenone 2 μg 12 hrs, larvae L3  (128) Rotenone 8 μg 12 hrs, larvae L3  (101) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    51 heat shock, 4-day adult    95 Cadmium 50 mM 6 hrs, larvae L3  136 Cadmium 50 mM 12 hrs, larvae L3  (190) Cadmium 50 mM 48 hrs, 4-day adult  102 Cadmium 100 mM 48 hrs, 4-day adult  125 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult  (165) Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult  115 Ethanol 2.5% 3 hrs, larvae L3  102 Ethanol 5% 3 hrs, larvae L3  123 Ethanol 10% 3 hrs, larvae L3    100 Caffeine 1.5 mg/ml 4 hrs, larvae L3  115 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  122 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult  107 Paraquat 10 mM 48 hrs, 4-day adult    85 Rotenone 2 μg 12 hrs, larvae L3  128 Rotenone 8 μg 12 hrs, larvae L3  101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    66 cold shock, 4-day adult    51 heat shock, 4-day adult    95 Cadmium 50 mM 6 hrs, larvae L3    136 Cadmium 50 mM 12 hrs, larvae L3    190 Cadmium 50 mM 48 hrs, 4-day adult    102 Cadmium 100 mM 48 hrs, 4-day adult    125 Copper 0.5 mM 12 hrs, larvae L3    46 Copper 15 mM 48 hrs, 4-day adult    165 Zinc 5 mM 12 hrs, larvae L3    55 Zinc 4.5 mM 48 hrs, 4-day adult    115 Ethanol 2.5% 3 hrs, larvae L3    102 Ethanol 5% 3 hrs, larvae L3    123 Ethanol 10% 3 hrs, larvae L3    100 Caffeine 1.5 mg/ml 4 hrs, larvae L3    115 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    122 Caffeine 25 mg/ml 48 hrs, 4-day adult    61 Paraquat 5 mM 48 hrs, 4-day adult    107 Paraquat 10 mM 48 hrs, 4-day adult    85 Rotenone 2 μg 12 hrs, larvae L3    128 Rotenone 8 μg 12 hrs, larvae L3    101 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_23 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD46767 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004868 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4079-RA;CG4422-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal GdiCA07108 GdiN7-3 lethal | larval stage (with GdiL319) GdiN7-3 lethal | larval stage (with GdiN7-3) GdiL319 lethal | larval stage | recessive GdiAF160 GdiL319 GdiN7-3 lethal | pharate adult stage (with GdiAK307) GdiN7-3 lethal | pharate adult stage (with GdiN7-3) GdiAK307 lethal | pharate adult stage | recessive GdiAK307 lethal | recessive GdiH1 GdiH4 GdiJ1 GdiJ2 GdiJ3C partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 GdiGD11312 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 GdiGD11312 Phenotype manifest in Allele embryonic epidermis GdiL319 embryonic epidermis (with GdiAK307) GdiL319 embryonic epidermis (with GdiL319) GdiAK307 melanotic mass GdiL319 mesothoracic tergum, with Scer\GAL4pnr-MD237 GdiGD11312 pole cell (with GdiAK307) GdiL319 pole cell (with GdiL319) GdiAK307 pole cell | germline clone GdiL319 puparium GdiL319 trichogen cell, with Scer\GAL4pnr-MD237 GdiGD11312
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of Gdi Class Mutagen Stocks Known lesion GdiEY00735 P-element activity 2 -- GdiN7-3 2 -- GdiAF160 ethyl methanesulfonate 1 Yes Gdic06066 piggyBac transposase 1 -- Gdie00888 piggyBac transposase 1 -- GdiGS14514 1 -- GdiMI05537 1 -- GdiNP5210 1 -- GdiAK307 ethyl methanesulfonate 0 Yes Gdic06838 piggyBac transposase 0 -- GdiCA07108 P-element activity 0 Yes GdiCPTI001693 piggyBac transposase 0 Yes GdiCPTI002649 piggyBac transposase 0 Yes GdiH1 0 -- GdiH2 0 -- GdiH4 0 -- GdiJ1 0 -- GdiJ2 0 -- GdiJ3C 0 -- GdiL319 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gdi Class Mutagen Stocks Known lesion GdiGD11312 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GdiGL00563 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GdiJF02617 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GdiKK104812 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GdiNIG.4422R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GdiScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)30A-C (Lane and Kalderon, 1993) Df(2L)50 (Ricard et al., 2001, Lane and Kalderon, 1993) Df(2L)TE2 (Lane and Kalderon, 1993) Df(2L)γ1 (Ricard et al., 2001) Df(2L)γ4 (Ricard et al., 2001, Lane and Kalderon, 1993) Df(2L)γ12 (Lane and Kalderon, 1993) Df(2L)γ25 (Ricard et al., 2001) Df(2L)γ29 (Ricard et al., 2001, Lane and Kalderon, 1993)
Not disrupted in	Df(2L)132 (Ricard et al., 2001) Df(2L)166 (Ricard et al., 2001) Df(2L)169 (Ricard et al., 2001) Df(2L)176 (Ricard et al., 2001) Df(2L)200 (Ricard et al., 2001) Df(2L)210 (Ricard et al., 2001) Df(2L)232 (Ricard et al., 2001, Lane and Kalderon, 1993) Df(2L)255 (Ricard et al., 2001) Df(2L)A4 (Ricard et al., 2001) Df(2L)γ1 (Lane and Kalderon, 1993) Df(2L)γ7 (Lane and Kalderon, 1993) Df(2L)γ25 (Lane and Kalderon, 1993) Df(2L)γ27 (Ricard et al., 2001, Lane and Kalderon, 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11312} NA P{KK104812} NA P{NIG.4422R} NA P{TRiP.GL00563} NA P{TRiP.JF02617} NA P{UAS-Gdi.GFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG33298EP2080 NA P{EPgy2}GdiEY00735 NA P{GSV1}C388C388 NA P{GSV6}GdiGS14514 NA insertion of enhancer trap binary system P{GawB}GdiNP5210 No miscellaneous insertions Mi{MIC}GdiMI05537 NA P{PTT-GA}GdiCA07108 NA P{SUPor-P}CG33298KG04393 NA P{UAST-YFP.Rab18.S19N}CG3329802 NA PBac{681.P.FSVS-1}GdiCPTI001693 NA PBac{769.FSVS-1}GdiCPTI002649 NA PBac{PB}Gdic06066 NA PBac{PB}Gdic06838 NA PBac{RB}Gdie00888 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
GDP-dissociation inhibitor activity inferred from direct assay (Garrett et al., 1993)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
GDP-dissociation inhibitor activity inferred from sequence or structural similarity with Saccharomyces GDI1 (FlyBase, 1992-) non-traceable author statement (Zahner, 1993.3.3) Rab GDP-dissociation inhibitor activity inferred from electronic annotation with InterPro:IPR000806 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) protein transport inferred from electronic annotation with InterPro:IPR000806 (FlyBase Curators et al., 2004-) vesicle-mediated transport non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
synaptic vesicle non-traceable author statement (Lloyd et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Gdi - Akap200 experimental knowledge based (Guruharsha et al., 2011) Gdi - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Gdi - CG10638 experimental knowledge based (Guruharsha et al., 2011) Gdi - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - CG5548 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - CG6084 experimental knowledge based (Guruharsha et al., 2011) Gdi - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - CG7787 experimental knowledge based (Guruharsha et al., 2011) Gdi - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - EndoGI experimental knowledge based (Guruharsha et al., 2011) Gdi - Eno experimental knowledge based (Guruharsha et al., 2011) Gdi - GstE6 experimental knowledge based (Guruharsha et al., 2011) Gdi - GstO3 experimental knowledge based (Guruharsha et al., 2011) Gdi - Hop experimental knowledge based (Guruharsha et al., 2011) Gdi - Hsc70Cb experimental knowledge based (Guruharsha et al., 2011) Gdi - Kdm4A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Gdi - Moe experimental knowledge based (Guruharsha et al., 2011) Gdi - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Gdi - Rab10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Rab14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Rab18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Rab3 experimental knowledge based (Guruharsha et al., 2011) Gdi - Rab35 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Gdi - Rab7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - SP2637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - Uch experimental knowledge based (Guruharsha et al., 2011) Gdi - capt experimental knowledge based (Guruharsha et al., 2011) Gdi - dlg1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gdi - regucalcin experimental knowledge based (Guruharsha et al., 2011) Gdi - rush pull down, anti tag western blot (Gailite et al., 2012) Gdi - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gdi allele Gene References unspecified fs(2)AL289 (Cheney et al., 2002) Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60367 DroID - A comprehensive database of gene and protein interactions. • FBgn0004868 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34264
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63XVP8 Dipteran inclusive ortholog search EOG6QVCMD Insect inclusive ortholog search EOG6MKMBQ Arthropod inclusive ortholog search EOG669P97 Metazoa inclusive ortholog search EOG6N0H79
Orthologs in Drosophila Species (EOG63XVP8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gdi     Drosophila simulans   Dsim\GD22354 Y   Drosophila sechellia   Dsec\GM12441 Y   Drosophila erecta   Dere\GG24025 Y   Drosophila yakuba   Dyak\GE10500 Y   Drosophila ananassae   Dana\GF21994 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18172 Y   Drosophila persimilis   Dper\GL25634 Y   Drosophila willistoni   Dwil\GK24240 Y   Drosophila virilis   Dvir\GJ18203 Y   Drosophila mojavensis   Dmoj\GI17638 Y   Drosophila grimshawi   Dgri\GH10775 Y
Orthologs in non-Drosophila Dipterans (EOG6QVCMD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012904   Anopheles gambiae Malaria mosquito  Agam\AGAP010025   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015309
Orthologs in non-Dipteran Insects (EOG6MKMBQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Gdi   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG033544   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG028068   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13872   Atta cephalotes Leafcutter ant  Acep\ACEP22628   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15485   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23091   Linepithema humile Argentine ant  Lhum\LH18410   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19451   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009608   Bombyx mori Silkmoth  Bmor\BGIBMGA001119   Pediculus humanus Human body louse  Phum\PHUM614460   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07497
Orthologs in non-Insect Arthropods (EOG669P97)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Wdr37   Ixodes scapularis Deer tick  Isca\ISCW017892
Orthologs in non-Arthropod Metazoa (EOG6N0H79)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\gdi-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004785gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010748gn   Danio rerio Zebrafish  Drer\ENSDARG00000005879   Danio rerio Zebrafish  Drer\gdi2   Danio rerio Zebrafish  Drer\gdi1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000009337   Xenopus tropicalis Western clawed frog  Xtro\gdi1   Xenopus tropicalis Western clawed frog  Xtro\gdi2   Gallus gallus Domestic chicken  Ggal\GDI2   Mus musculus House mouse  Mmus\Gdi1   Mus musculus House mouse  Mmus\Gdi2   Rattus norvegicus Norway rat  Rnor\Gdi2   Rattus norvegicus Norway rat  Rnor\Gdi1   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042227   Homo sapiens Human  Hsap\GDI2   Homo sapiens Human  Hsap\GDI1
Human Orthologs (2)
Gene OMIM HGNC Hsap\GDI2     Hsap\GDI1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22354 Drosophila sechellia Dsec\GM12441 Drosophila erecta Dere\GG24025 Drosophila yakuba Dyak\GE10500 Drosophila ananassae Dana\GF21994 Drosophila pseudoobscura pseudoobscura Dpse\GA18172 Drosophila persimilis Dper\GL25634 Drosophila willistoni Dwil\GK24240 Drosophila virilis Dvir\GJ18203 Drosophila mojavensis Dmoj\GI17638 Drosophila grimshawi Dgri\GH10775
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	27309 y1 v1; P{TRiP.JF02617}attP2 42332 y1 w*; Mi{MIC}GdiMI05537/SM6a 36603 y1 sc* v1; P{TRiP.GL00563}attP2 15040 y1 w67c23; P{EPgy2}GdiEY00735/CyO 6473 w1; dpps1 GdiAF160 b1 cn1 bw1/SM1
Harvard	- PBac{PB}Gdic06066 - PBac{RB}Gdie00888
Kyoto	205841 y1 w67c23; P{GSV6}GdiGS14514/SM1 104900 y* w*; P{GawB}GdiNP5210 / CyO, P{UAS-lacZ.UW14}UW14 114404 yd2 w1118 P{ey-FLP.N}2; P{EPgy2}GdiEY00735 P{neoFRT}40A/CyO y+
VDRC	v108693 P{KK104812}VIE-260B v26537 w1118; P{GD11312}v26537/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR26G12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 304 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD46767 LP03430
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01475 AT01485 AT04353 AT08839 AT19767 AT20136 AT24911 AT30665 GH04503 GH12367 GH14244 GH14784 GH14826 GH15610 GH17525 GH18925 GH28082 GM01920 GM01921 GM01963 GM04367 GM04869 GM13883 GM17053 GM17620 GM22047 HL02741 LD12968 LD14936 LD24880 LD31021 LD42282 LD43234 LD47888 LP02533 LP03011 LP07162 LP13070 LP19564 RE09204 RE12278 RE29106 RE30938 RE32136 RE42565 RE45187 RE66211 RE71233 RE72455 RE74303 RH24028 RH31254 RH31354 RH56778 RH57828 SD01776 SD01923 SD07004 SD14346 SD15218 SD15477 SD18125 SD21529 SD25105
Other clones	130 1311 7760 8728 15532 17714 38179 58059 63108 65608 66337 66384 67290 76316 77586 99881 119791 120697 122140 122500 125081 125454 156866 174504 193079 194777 281041 282154 291905 296240 CK01.9A.B8 CK01.27D.G3 CK01.84C.D7 CK01.88B.A10 CK01.116C.D9 CK01.123D.B12 CK01.133A.F10 Dmel_dig_004025_0702_0686 Dmel_dig_005506_0656_0596 Dmel_dig_014573_0639_1591 Dmel_dig_016061_0605_1222 EC38130 EC255372 EC256941 EK067110 EK069633 EK105728 EK107010 EK107256 EK122634 EK130254 EK131744 EK150856 EK164938 EK171351 EK188733 EK193038 EK194243 EK194305 EK195548 EK208428 EK222537 EK239438 EK245463 EK259939 EK275628 EK279335 EK296223 EK305946 EN05828 EN09562 EP06748 EP07514 EP07948 EP09303 EP12108 ESG011a.E7.4_G02 FGH111D05 FGM218B05 RP003002108 RP003009174 RP003010241 RP003014527 RP003015280 RP003015293 RP003018654 RP003020229 RP003020351 RP003026792 RP003029323 RP003043205 RP003046336 RP003049179 RP003054864 RP003055542 RP003056063 RP003059732 RP003062423 RP003062793 RP003071132 RP003072300 RP003074691 RP003074888 RP003080385 RP003081433 RP003081829 RP003082849 RP003087334 RP003092607 RP003098118 RP003101161 RP003102930 RP003103083 RP003106109 RP003108223 RP003124519 RP003126228 RP003132350 RP003141397 RP003143352 RP003154716 RP003157017 RP003164592 RP003164847 RP003167476 RP003169078 RP003179248 RP003179333 RP003181984 RP003182140 RP003185657 RP003188250 RP003199807 RP003203258 RP003203927 RP003204975 RP003206046 RP003209164 RP003212986 RP003225402 RP003227793 RP003231778 RP003236301 RP003248877 RP003251993 RP003257554 RP003261668 RP003278650 RP003288197 RP003295396 RP003304276 RP003304613 RP003304678 RP003306876 RP003325875 RP003334900 RP003336466 RP003347014 RP003352458 RP003355229 RP003358724 RP003362111 RP003365198 RP003366984 RP003368822 RP003368904 RP003371422 RP003376851 RP003379249 RP003380196 RP003382566 RP003384877 RP003385725 RP003388551 RP003390340 RP003395059 RP003397392 RP003398267 RP003400042 RP003404522 RP003404830 RP003405506 RP003405985 RP003412014 RP003419224 RP003420595 RP003424248 RP003441943 RP003445104 RP003445196 RP003445842 RP003451343 RP003454913 RP003457689 RP003461557 RP003464723 RP003471792 RP003474154 RP003475107 RP003477385 RP003478536 RP003478665 RP003486675 RP003489568 RP003490544 RP003491677 RP003493271 RP003496324 RP003498513 RP003500093 RP003506745 RP003509630 RP003513224 RP003514381 RP003515168 RP003516016 RP003517898 RP003519244 RP003521749 RP003523975 RP003527641 RP003530844 RP003537435 RP003539122 RP003554687 RP003571208 RP003574713 RP003584518 RP003588089 RP003602613 RP003626026 RP003635916 RP003636457 RP003645796 RP003650490 RP003658992 RP003667364 RP003681684
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004868 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34264
Antibody Information
	polyclonal (Ricard et al., 2001)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Gdi l(2)N7-3 (Ricard et al., 2001)
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against Gdi that is transfected into S2 treated with Listeria monocytogenes reveals Gdi to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape. (Cheng et al., 2005) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Area matching Drosophila GDP dissociation inhibitor homologue gene, Acc. No. L03209. (Davies, 2001.3.15) Gdi can cause the dissociation of S.cerevisiae Sec4 from membranes in a cell free assay and can inhibit dissociation of GDP from Sec4. (Garrett et al., 1993) Gdi is the Drosophila homolog of the bovine smgp25a GDP dissociation inhibitor. (Zahner and Cheney, 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078800 NM_001259024 RefSeq (Proteins) • NP_523524 NP_001245953 DDBJ / EMBL / GenBank • AAA28567 AAF52777 AAL39842 AAO39567 AFH03627 AI515084 AW943868 AX093884 AY069697 BT003563 BZ665520 CZ470467 CZ471023 CZ478725 L03209 Entrez Gene - A searchable database of RefSeq genes. • 34264 UniProtKB/TrEMBL • Q9VLB7 Q24349
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • GDP dissociation inhibitor (IPR018203) Rab GDI protein (IPR000806) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD46767
Linkouts
	BioGRID - A database of protein and genetic interactions • 60367 DroID - A comprehensive database of gene and protein interactions. • FBgn0004868 DRSC - Results from RNAi screens. • FBgn0004868 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004868 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4079-RA;CG4422-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004868 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34264 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34264 modMine - Data generated by the modENCODE project. • FBgn0004868
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG4422 (Nakahara et al., 2005, Verstreken and Bellen, 2000.9.4, Laviolette et al., 2005, Molnar et al., 2006, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Hughes et al., 2008, Cammarato et al., 2011) dGDI (Zahner, 1993.3.3, Garrett and Novick, 1995, Garrett et al., 1993, Zahner and Cheney, 1993, Zahner and Cheney, 1992, ) GDI (Cheng et al., 2005, Sangji et al., 2005, Holtzman et al., 2005, Marella et al., 2003, Ricard et al., 2001, Cheney et al., 2001, Lloyd et al., 2000, Fernandez et al., 2000, Jakubowski et al., 1998, Dong et al., 1999, Jakubowski et al., 1997, Bassett et al., 1997, Jakubowski and Cheney, 1997, Zahner and Cheney, 1992, Cheney et al., 2007, Domanitskaya et al., 2007) GdI   Gdi (Laviolette et al., 2005, Altenhein et al., 2006, Stuart et al., 2007, Fischer et al., 2012, Buszczak et al., 2007, Zhang et al., 2007, Molnar et al., 2006, Font-Burgada et al., 2008, Ma et al., 2012, Perkins et al., 2009.8.10, Reis et al., 2010, Gailite et al., 2012, Japanese National Institute of Genetics, 2012.5.21) l(2)N7-3 (Bloomington Drosophila Stock Center, 1997.12.5, Lane and Kalderon, 1993, ) N7-3 (Ricard et al., 2001) rab GDI (Jakubowski et al., 1999, Lewis et al., 1996)
Name Synonym	Gdi-related (Zhang et al., 2004) GDP dissociation inhibitor (Cammarato et al., 2011) rab GDP dissociation inhibitor (Fernandez et al., 2000) Rab GDP dissociation inhibitor (Cheney et al., 2007, Gailite et al., 2012)
Secondary FlyBase IDs
	FBgn0010224 FBgn0014258
References ( 91 )
Generate a list of	All references relating to this gene ( 91 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 9 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 28 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Patent  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 1 )
Recent research papers ( 4 )
	Fischer et al., 2012, Proc. Biol. Sci. 279(1738): 2636--2644 Conserved properties of Drosophila and human spermatozoal mRNA repertoires. [FBrf0218415] Gailite et al., 2012, Mol. Biol. Cell 23(3): 433--447 The phosphoinositide-associated protein Rush hour regulates endosomal trafficking in Drosophila. [FBrf0217308] Ma et al., 2012, Genetics 190(4): 1299--1308 Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. [FBrf0217992] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Show all research papers ...