bab, bric-a-brac, bric a brac, bab-I, bric a brac I
Please see the JBrowse view of Dmel\bab1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.53
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
5.4 (northern blot)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bab1 using the Feature Mapper tool.
Comment: maternally deposited
Transcript expression in the ovary is restricted to the cells that form the terminal filaments. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs.
Within the leg imaginal disc, the bab transcript is detected in the primordia for tarsal segments 2 to 4 and the distal margin of tarsal segment 1.
The bab protein is located in the nucleus.
Protein expression in the ovary is restricted to the cells that form the terminal filaments.Protein is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs. This expression is graded with highest expression in TS3 and TS4 and lower expression in TS1 and TS2 as per FBrf0065404.In the female genital disc strongest protein expression is observed in the vaginal plate primordium and the A8 tergite.In the male genital disc strongest protein expression is observed in a region of the male genital primordium.bab1-expressing cells are found in the central brain hemisphers and the thoracic ganglia.
Starting in larval mid-third instar, lacZ expression is detected in a concentric domain in leg and antennal imaginal discs. These expression domains correspond to the primordia of the tarsus, and subdistal structures of the antenna, respectively. By late third larval instar, expression is stronger, and the primordia of tarsal segments 2 to 4, and of the distal portion of tarsal segment 1, are stained. The expression displays a graded and wave-like pattern: tarsal folds 3 and 4 stain more than folds 1 and 2, and the ridges of the folds stain more than the furrows. This staining pattern is still visible in 6 hour-old prepupae. In adults, staining is seen in two segments of the antennal basal cylinder.
Comment: post-mitotic
Comment: post-mitotic
Comment: post-mitotic
GBrowse - Visual display of RNA-Seq signals
View Dmel\bab1 in GBrowse 23-0.5
3-1.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for merge of: bab1 anon-WO0118547.639
Source for merge of: bab CG13910
"fap" (female abdomen pattern) is very likely to correspond to the "bab" locus (which is composed of the paralogous "bab1" and "bab2" genes).
Annotations CG9097 and CG13910 merged as CG9097 in release 3 of the genome annotation.
Source for merge of bab1 anon-WO0118547.639 was sequence comparison ( date:051113 ).
DNA-protein interactions: genome-wide binding profile assayed for bab1 protein in 0-12 hr embryos; see mE1_TFBS_bab1 collection report.
bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2.
bab1 expression is modulated segment- and sex-specifically in sexually dimorphic species but is uniform in sexually monomorphic species.
bab1 integrates regulatory inputs from the homeotic and sex-determination pathways to control sexually dimorphic abdominal pigmentation and segment morphology.
bab1 is required for the formation of the terminal filaments in the third larval instar ovary. The N terminal region of the protein encodes for a regulator of gene expression that contains the BTB domain.
bab1 is cell autonomously required for the formation of terminal filaments and is crucial for the normal morphogenesis of the ovary.
bab1 is necessary for terminal filament cluster formation which is required in turn for ovariole morphogenesis to take place.
bab1 function is dosage-dependent and is required in a graded manner for the specification of tarsal segments. This and its expression pattern suggests that bab1 function may specify segment identity in the tarsus. Strong mutants and deletions for bab1 show a temperature-sensitive haploinsufficient dominant phenotype.
