FB2019_05, released Oct 15, 2019

Gene: Dmel\bab1

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General Information
Symbol
Dmel\bab1
Species
D. melanogaster
Name
bric a brac 1
Annotation Symbol
CG9097
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004870
Gene Model Status
Current
Stock Availability
24 publicly available
Gene Snapshot
bric a brac 1 (bab1) encodes a transcriptional regulator that functions partially redundantly with the product of bab2. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
bab, bric-a-brac, bric a brac, bab-I, bric a brac I
Key Links
Genomic Location
Cytogenetic map
61E2-61F1
Sequence location
3L:1,036,369..1,101,089 [-]
Recombination map
3-0.5
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
AT DNA binding; protein binding
Predictions / Assertions
DNA-binding transcription factor activity
Summaries
Gene Group (FlyBase)
PIPSQUEAK TRANSCRIPTION FACTORS -
Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).
Protein Function (UniProtKB)
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
(UniProt, Q9W0K7)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\bab1 or the JBrowse view of Dmel\bab1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.53
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
bab1-RB
FBtr0072642
NM_167852
5340
977
bab1-RC
FBtr0333268
NM_001274310
5319
970
bab1-RD
FBtr0333269
NM_001274311
5322
971
bab1-RE
FBtr0333270
NM_001274312
5337
976
Additional Transcript Data and Comments
Reported size (kB)
5.4 (northern blot)
(Couderc et al., 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
bab1-PB
FBpp0072538
103.3
977
8.25
NP_728565
AAF47439
bab1-PC
FBpp0305466
102.6
970
8.25
NP_001261239
AGB93934
bab1-PD
FBpp0305467
102.7
971
8.25
NP_001261240
AGB93935
bab1-PE
FBpp0305468
103.3
976
8.25
NP_001261241
AGB93936
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bab1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
AT DNA binding
inferred from direct assay
(Lours et al., 2003)
protein binding
inferred from physical interaction with FLYBASE:bip2; FB:FBgn0026262
(Pointud et al., 2001)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
DNA-binding transcription factor activity
traceable author statement
(Christiansen et al., 2002)
Biological Process (11 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
eye-antennal disc morphogenesis
inferred from expression pattern
(assigned by UniProt )
(Couderc et al., 2002)
leg disc morphogenesis
inferred from expression pattern
(assigned by UniProt )
(Couderc et al., 2002)
sex differentiation
inferred from mutant phenotype
(Kopp et al., 2000)
inferred from genetic interaction with FLYBASE:abd-A; FB:FBgn0000014
(Kopp et al., 2000)
inferred from genetic interaction with FLYBASE:Abd-B; FB:FBgn0000015
(Kopp et al., 2000)
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
female sex differentiation
traceable author statement
(Billeter et al., 2002)
negative regulation of developmental pigmentation
traceable author statement
(Christiansen et al., 2002)
negative regulation of male pigmentation
non-traceable author statement
(Billeter et al., 2002)
regulation of developmental pigmentation
traceable author statement
(Simpson, 2002)
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of transcription, DNA-templated
traceable author statement
(Christiansen et al., 2002)
sex differentiation
traceable author statement
(Christiansen et al., 2002)
sex-specific pigmentation
traceable author statement
(Simpson, 2002, Sanchez and Guerrero, 2001, Zarkower, 2001)
transcription, DNA-templated
traceable author statement
(assigned by UniProt )
(Couderc et al., 2002)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
nucleus
inferred from direct assay
(assigned by UniProt )
(Couderc et al., 2002)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | faint | ubiquitous
(Fisher et al., 2012)
third instar larval stage
ventral thoracic disc | restricted
(Couderc et al., 2002)
wandering third instar larval stage
eye-antennal disc | restricted
(Godt et al., 1993)
third instar larval stage L2
ventral thoracic disc | restricted
(Godt et al., 1993)
prepupal stage
ovary | restricted
(Couderc et al., 2002)
Additional Descriptive Data
Transcript expression in the ovary is restricted to the cells that form the terminal filaments. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs.
(Couderc et al., 2002)
Within the leg imaginal disc, the bab transcript is detected in the primordia for tarsal segments 2 to 4 and the distal margin of tarsal segment 1.
(Godt et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
ventral thoracic disc | restricted
(Couderc et al., 2002, Godt et al., 1993)
eye-antennal disc | restricted
(Godt et al., 1993)
wandering third instar larval stage
male genital disc | restricted
(Couderc et al., 2002)
female genital disc | restricted
(Couderc et al., 2002)
embryonic/larval central nervous system | restricted
(Couderc et al., 2002)
prepupal stage
tarsal segment
(Godt et al., 1993)
central nervous system | restricted
(Couderc et al., 2002)
prepupal stage P1
ovary | restricted

Comment: puparium formation

(Couderc et al., 2002)
pupal stage P7 -- pharate adult stage P14
pupal epidermis | dorsal | restricted
(Salomone et al., 2013)
pharate adult stage P9 -- P14
oenocyte
(Salomone et al., 2013)
Additional Descriptive Data
The bab protein is located in the nucleus.
(Salomone et al., 2013, Godt et al., 1993)
Two cis regulatory elements govern bab1 expression in the pupal abdomen: one element that regulates bab1 expression in segments A2–A4 of both sexes and a second, dimorphic element that regulates expression in the posterior segments A5–A7 of females.
(Williams et al., 2008)
Protein expression in the ovary is restricted to the cells that form the terminal filaments.Protein is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs. This expression is graded with highest expression in TS3 and TS4 and lower expression in TS1 and TS2 as per FBrf0065404.In the female genital disc strongest protein expression is observed in the vaginal plate primordium and the A8 tergite.In the male genital disc strongest protein expression is observed in a region of the male genital primordium.bab1-expressing cells are found in the central brain hemisphers and the thoracic ganglia.
(Couderc et al., 2002)
Starting in larval mid-third instar, lacZ expression is detected in a concentric domain in leg and antennal imaginal discs. These expression domains correspond to the primordia of the tarsus, and subdistal structures of the antenna, respectively. By late third larval instar, expression is stronger, and the primordia of tarsal segments 2 to 4, and of the distal portion of tarsal segment 1, are stained. The expression displays a graded and wave-like pattern: tarsal folds 3 and 4 stain more than folds 1 and 2, and the ridges of the folds stain more than the furrows. This staining pattern is still visible in 6 hour-old prepupae. In adults, staining is seen in two segments of the antennal basal cylinder.
(Godt et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(assigned by UniProt )
(Couderc et al., 2002)
Expression Deduced from Reporters
Reporter: P{A92}bab1A30
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hindgut
(Bellen et al., 1989)
metameric furrow
(Bellen et al., 1989)
embryonic/larval proventriculus
(Bellen et al., 1989)
anal pad | presumptive
(Bellen et al., 1989)
embryonic/larval digestive system | restricted
(Bellen et al., 1989)
embryonic stage 10 -- 17
stomodeum
(O'Kane and Gehring, 1987)
proctodeum
(O'Kane and Gehring, 1987)
epidermis | segmentally repeated
(O'Kane and Gehring, 1987)
embryonic stage 11 -- 17
embryonic labial segment
(O'Kane and Gehring, 1987)
embryonic stage 17
embryonic/larval anal pad
(O'Kane and Gehring, 1987)
embryonic/larval proventriculus
(O'Kane and Gehring, 1987)
embryonic/larval hindgut
(O'Kane and Gehring, 1987)
Reporter: P{A92}bab1P
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
antennal disc
(Godt et al., 1993)
ventral thoracic disc
(Godt et al., 1993)
Reporter: P{GawB}bab1Agal4-5
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
terminal filament
(Sahai-Hernandez and Nystul, 2013)
germarium cap cell
(Sahai-Hernandez and Nystul, 2013)
embryonic stage 17
embryonic/larval posterior spiracle
(Cabrera et al., 2002)
embryonic/larval proventriculus
(Cabrera et al., 2002)
embryonic/larval salivary gland
(Cabrera et al., 2002)
larval stage
embryonic/larval proventriculus
(Sieber and Thummel, 2012)
larval stage | female
terminal filament
(Cabrera et al., 2002)
somatic cell of ovariole | apical

Comment: apical side of ovary

(Cabrera et al., 2002)
somatic cell of ovariole | basal

Comment: basal side of cell

(Cabrera et al., 2002)
larval stage | male
testis
(Cabrera et al., 2002)
male germline cell

Comment: post-mitotic

(Cabrera et al., 2002)
third instar larval stage
larval enteroendocrine cell | subset
(Lajeunesse et al., 2010)
embryonic/larval midgut longitudinal visceral muscle
(Lajeunesse et al., 2010)
circular visceral muscle fiber | subset
(Lajeunesse et al., 2010)
embryonic/larval midgut enterocyte | subset
(Lajeunesse et al., 2010)
embryonic/larval proventriculus
(Lajeunesse et al., 2010)
larval enteroendocrine cell
(Lajeunesse et al., 2010)
wandering third instar larval stage
ventral thoracic disc | restricted
(Cabrera et al., 2002)
antennal disc | restricted
(Cabrera et al., 2002)
basal cylinder | precursor
(Cabrera et al., 2002)
presumptive arista
(Cabrera et al., 2002)
female genital disc
(Cabrera et al., 2002)
wing disc | restricted
(Cabrera et al., 2002)
haltere disc | restricted
(Cabrera et al., 2002)
wandering third instar larval stage -- prepupal stage
presumptive tarsal segment 2
(Cabrera et al., 2002)
presumptive tarsal segment 3
(Cabrera et al., 2002)
presumptive tarsal segment 4
(Cabrera et al., 2002)
adult stage | female
terminal filament
(Cabrera et al., 2002)
adult stage | male
male germline cell

Comment: post-mitotic

(Cabrera et al., 2002)
oogenesis
terminal filament
(Park et al., 2007)
germarium cap cell
(Park et al., 2007)
Reporter: P{GawB}bab1Gal4
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage | female
somatic cell of ovariole
(Bolivar et al., 2006)
pupal stage | female
terminal filament
(Bolivar et al., 2006)
germarium cap cell
(Bolivar et al., 2006)
basal stalk | faint
(Bolivar et al., 2006)
adult stage | female
terminal filament
(Bolivar et al., 2006)
escort stem cell
(Bolivar et al., 2006)
escort cell
(Bolivar et al., 2006)
germarium cap cell
(Bolivar et al., 2006)
Reporter: P{GawB}bab1Pgal4-2
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
embryonic/larval posterior spiracle
(Cabrera et al., 2002)
embryonic/larval proventriculus
(Cabrera et al., 2002)
embryonic labral segment
(Cabrera et al., 2002)
larval stage | female
terminal filament
(Cabrera et al., 2002)
somatic cell of ovariole | apical

Comment: apical side of ovary

(Cabrera et al., 2002)
larval stage | male
testis
(Cabrera et al., 2002)
male germline cell

Comment: post-mitotic

(Cabrera et al., 2002)
wandering third instar larval stage
ventral thoracic disc | restricted
(Cabrera et al., 2002)
presumptive prothoracic structures from prothoracic leg disc
(Cabrera et al., 2002)
presumptive mesothoracic structures from mesothoracic leg disc
(Cabrera et al., 2002)
presumptive metathorax structures from metathoracic leg disc
(Cabrera et al., 2002)
antennal disc | restricted
(Cabrera et al., 2002)
basal cylinder | precursor
(Cabrera et al., 2002)
presumptive arista
(Cabrera et al., 2002)
eye disc posterior to the morphogenetic furrow
(Cabrera et al., 2002)
female genital disc
(Cabrera et al., 2002)
male genital disc
(Cabrera et al., 2002)
wing disc | restricted
(Cabrera et al., 2002)
haltere disc | restricted
(Cabrera et al., 2002)
wandering third instar larval stage -- prepupal stage
presumptive tarsal segment 2
(Cabrera et al., 2002)
presumptive tarsal segment 3
(Cabrera et al., 2002)
presumptive tarsal segment 4
(Cabrera et al., 2002)
adult stage | female
terminal filament
(Cabrera et al., 2002)
adult stage | male
male germline cell
(Cabrera et al., 2002)
male germline cyst
(Cabrera et al., 2002)
adult stage
antennal olfactory receptor neuron | subset
(Li et al., 2016)
oogenesis & adult stage | female
terminal filament
(Hartman et al., 2010)
adult stage | female & oogenesis
germarium cap cell
(Hartman et al., 2010)
oogenesis
germarium cap cell
(Guo and Wang, 2009)
terminal filament
(Guo and Wang, 2009)
Reporter: P{GawB}bab1
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
ventral thoracic disc | restricted
(Azpiazu and Morata, 2002)
Reporter: P{lArB}bab1A128.1F3
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hindgut
(Bellen et al., 1989)
metameric furrow
(Bellen et al., 1989)
embryonic/larval proventriculus
(Bellen et al., 1989)
anal pad | presumptive
(Bellen et al., 1989)
embryonic/larval digestive system | restricted
(Bellen et al., 1989)
larval stage
ventral thoracic disc | restricted
(Mukherjee et al., 2000)
third instar larval stage
antennal disc | restricted
(Godt et al., 1993)
ventral thoracic disc | restricted
(Godt et al., 1993)
antennal disc | central
(Li et al., 2016)
prepupal stage
ventral thoracic disc | restricted
(Godt et al., 1993)
antennal disc | restricted
(Godt et al., 1993)
adult stage
basal cylinder | restricted
(Godt et al., 1993)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bab1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bab1
Transgenic constructs containing regulatory region of bab1
Deletions and Duplications ( 9 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4p339
lethal, with Scer\GAL4T80
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die, with Scer\GAL4hs.PB
Sterility
Allele
female sterile
female sterile | recessive
Other Phenotypes
Allele
body color defective | female
body color defective | female | recessive
decreased fecundity | female
size defective | adult stage, with Scer\GAL4GMR42B09
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4Bx-MS1096
visible | dominant | heat sensitive
visible | recessive
Phenotype manifest in
Allele
abdominal tergite 5 | female
abdominal tergite 6 | female
abdominal tergite 7 | female
antenna
basal cylinder
germarium
leg
macrochaeta
macrochaeta, with Scer\GAL4hs.PB
mesothoracic tarsal segment 2
mesothoracic tarsal segment 3
mesothoracic tarsal segment 4
mesothoracic tarsal segment 5
metathoracic tarsal segment 2
metathoracic tarsal segment 3
metathoracic tarsal segment 4
metathoracic tarsal segment 5
ovariole
ovariole | adult stage, with Scer\GAL4GMR42B09
ovary
ovary | adult stage, with Scer\GAL4GMR42B09
prothoracic tarsal segment 2
prothoracic tarsal segment 3
prothoracic tarsal segment 4
prothoracic tarsal segment 5
sex comb
sex comb | ectopic
tergite, with Scer\GAL4hs.PB
terminal filament
wing, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NACC1
2 of 15
Yes
Yes
Hsap\NACC2
2 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nacc1
1 of 15
Yes
No
Mmus\Nacc2
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
Rnor\Nacc1
1 of 13
Yes
No
Rnor\Nacc2
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\nacc1
1 of 12
Yes
Yes
Xtro\nacc2
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
Drer\bcl6ab
1 of 15
Yes
No
Drer\LOC559520
1 of 15
Yes
Yes
Drer\nacc1b
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\btb-13
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904IH )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\bab1
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004552
Drosophila simulans
Dsim\GD13499
Drosophila sechellia
Dsec\GM14241
Drosophila sechellia
Dsec\GM14240
Drosophila erecta
Dere\GG14628
Drosophila yakuba
Dyak\GE20986
Drosophila ananassae
Dana\GF10081
Drosophila pseudoobscura pseudoobscura
Dpse\GA23169
Drosophila persimilis
Dper\GL26926
Drosophila persimilis
Dper\GL16678
Drosophila willistoni
Dwil\GK16863
Drosophila virilis
Dvir\bab
Drosophila mojavensis
Dmoj\GI12712
Drosophila grimshawi
Dgri\GH15669
Drosophila grimshawi
Dgri\GH15670
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505F0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016039
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13522
Mayetiola destructor
Hessian fly
Mdes\Mdes008347
Mayetiola destructor
Hessian fly
Mdes\Mdes008210
Mayetiola destructor
Hessian fly
Mdes\Mdes008226
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001734
Anopheles gambiae
Malaria mosquito
Agam\AGAP006018
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011217
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03II )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012232
Danaus plexippus
Monarch butterfly
Dple\DPOGS208382-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208378-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208381-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008789
Heliconius melpomene
Postman butterfly
Hmel\HMEL008788
Apis florea
Little honeybee
Aflo\2551346228
Apis florea
Little honeybee
Aflo\2147493281
Apis florea
Little honeybee
Aflo\2551346132
Apis florea
Little honeybee
Aflo\2158746914
Apis mellifera
Western honey bee
Amel\LOC725189
Apis mellifera
Western honey bee
Amel\GB40870
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22471
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP22472
Bombus terrestris
Buff-tailed bumblebee
Bter\15214056
Linepithema humile
Argentine ant
Lhum\LH18503
Linepithema humile
Argentine ant
Lhum\LH18512
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a0e
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a0a
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002a0f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG036111
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG036110
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10194
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07459
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07460
Tribolium castaneum
Red flour beetle
Tcas\TC003627
Tribolium castaneum
Red flour beetle
Tcas\TC031038
Pediculus humanus
Human body louse
Phum\PHUM501430
Pediculus humanus
Human body louse
Phum\PHUM501420
Pediculus humanus
Human body louse
Phum\PHUM537020
Rhodnius prolixus
Kissing bug
Rpro\RPRC014183
Rhodnius prolixus
Kissing bug
Rpro\RPRC003948
Cimex lectularius
Bed bug
Clec\CLEC000425
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI26964
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI24405
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI52378
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI56663
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI48647
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084929
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI40633
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009658
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084532
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI065766
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI072471
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03179
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ABC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR012518
Strigamia maritima
European centipede
Smar\SMAR002763
Ixodes scapularis
Black-legged tick
Isca\ISCW010367
Ixodes scapularis
Black-legged tick
Isca\ISCW016996
Ixodes scapularis
Black-legged tick
Isca\ISCW019463
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71876.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g01140
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299763
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347243
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0WNB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z415
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Z304
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009559
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (23)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bab2
4 of 10
CG34376
4 of 10
lola
4 of 10
mamo
4 of 10
Trl
4 of 10
ttk
4 of 10
br
3 of 10
BtbVII
3 of 10
CG3726
3 of 10
CG8924
3 of 10
CG12236
3 of 10
CG32121
3 of 10
chinmo
3 of 10
fru
3 of 10
lolal
3 of 10
lov
3 of 10
psq
3 of 10
rib
3 of 10
ab
2 of 10
CG6118
2 of 10
CG6765
1 of 10
mod(mdg4)
1 of 10
pre-lola-G
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-0.5
    Cytogenetic map
    61E2-61F1
    Sequence location
    3L:1,036,369..1,101,089 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    61E2-61F1
    Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    61F1-61F3
    (determined by in situ hybridisation)
    (Godt et al., 1993)
    Experimentally Determined Recombination Data
    Location
    3-0.5
    (FlyBase, 2016)
    3-1.2
    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (24)
    Genomic Clones (47)
    cDNA Clones (36)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        polyclonal
        (Williams et al., 2008, Godt et al., 1993)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Source for merge of: bab1 anon-WO0118547.639
        (FlyBase, 1996-)
        Source for merge of: bab CG13910
        (FlyBase Genome Annotators, 2002-2003)
        Additional comments
        "fap" (female abdomen pattern) is very likely to correspond to the "bab" locus (which is composed of the paralogous "bab1" and "bab2" genes).
        (Couderc et al., 2002)
        Annotations CG9097 and CG13910 merged as CG9097 in release 3 of the genome annotation.
        (FlyBase Genome Annotators, 2002-2003)
        Source for merge of bab1 anon-WO0118547.639 was sequence comparison ( date:051113 ).
        (FlyBase, 1996-)
        Other Comments
        DNA-protein interactions: genome-wide binding profile assayed for bab1 protein in 0-12 hr embryos; see mE1_TFBS_bab1 collection report.
        (Negre et al., 2011)
        bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2.
        (Couderc et al., 2002)
        Pigmentation patterns specified by bab1 affect mating preferences, suggesting that sexual selection has contributed to the evolution of bab1 regulation.
        (Kopp et al., 2000)
        bab1 expression is modulated segment- and sex-specifically in sexually dimorphic species but is uniform in sexually monomorphic species.
        (Kopp et al., 2000)
        bab1 integrates regulatory inputs from the homeotic and sex-determination pathways to control sexually dimorphic abdominal pigmentation and segment morphology.
        (Kopp et al., 2000)
        bab1 is required for the formation of the terminal filaments in the third larval instar ovary. The N terminal region of the protein encodes for a regulator of gene expression that contains the BTB domain.
        (Couderc et al., 1995)
        bab1 is cell autonomously required for the formation of terminal filaments and is crucial for the normal morphogenesis of the ovary.
        (Godt and Laski, 1995)
        bab1 is necessary for terminal filament cluster formation which is required in turn for ovariole morphogenesis to take place.
        (Sahut-Barnola et al., 1995)
        bab1 function is dosage-dependent and is required in a graded manner for the specification of tarsal segments. This and its expression pattern suggests that bab1 function may specify segment identity in the tarsus. Strong mutants and deletions for bab1 show a temperature-sensitive haploinsufficient dominant phenotype.
        (Godt et al., 1993)
        Mutations in bab1 disrupt the formation of the terminal filaments in larval ovaries and cause severe disorganised adult ovaries. bab1 has been cloned and shown to be expressed in the terminal filament cells.
        (Godt et al., 1992)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 57 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (20)
        Reported As
        Symbol Synonym
        BAB
        (Cheng et al., 2013, Dey et al., 2009)
        BAB-1
        (Slattery et al., 2014)
        BAB1
        (Percival-Smith, 2017, Bartoletti et al., 2012, Kim et al., 2010, Pointud et al., 2001)
        Bab1
        (Rebeiz and Williams, 2017, Chaharbakhshi and Jemc, 2016, Webber et al., 2013, Deloger et al., 2009)
        CG13910
        CG9097
        (Ni et al., 2011.7.19, Ni et al., 2010.12.1, Deloger et al., 2009, Keleman et al., 2009.8.5)
        anon-WO0118547.639
        bab
        (Ho et al., 2018, Li et al., 2016, Verhulst and van de Zande, 2015, Corsetti and Azpiazu, 2013, Devi et al., 2013, Bartoletti et al., 2012, Eliazer and Buszczak, 2011, Gibert et al., 2011, Pueyo and Couso, 2011, Bosch et al., 2010, Robinett et al., 2010, Ebacher et al., 2007, Gibert et al., 2007, Schlötterer et al., 2007, Jeong et al., 2006, Keller, 2006, Kelly and Daniel, 2006, Galindo et al., 2005, Hatini et al., 2005, Bray and de Celis Ibeas, 2003, Cummins et al., 2003, Kopp et al., 2003, Williams et al., 2003, Wittkopp et al., 2003, Burtis, 2002, Christiansen et al., 2002, Chu et al., 2002, Galindo et al., 2002, Galindo et al., 2002, Panganiban and Rubenstein, 2002, Siegmund and Lehmann, 2002, Simpson, 2002, St Pierre et al., 2002, Bopp, 2001, Chen et al., 2001, Gibson and Palsson, 2001, Kopp et al., 2001, Shim et al., 2001, True et al., 2001, Galindo and Couso, 2000, Kopp et al., 2000, Mukherjee et al., 2000, Stern, 2000, King and Lin, 1999, Couso and Bishop, 1998, Duncan et al., 1998, Santamaria, 1998, Aplin and Kaufman, 1997, Buratovich and Bryant, 1997, Cavarec et al., 1997, Ito et al., 1996, Yamamoto et al., 1996, Couderc et al., 1995, Godt and Laski, 1995, Godt and Laski, 1995, Sahut-Barnola et al., 1995, Weber et al., 1995, Zollman et al., 1994, Godt et al., 1993, Godt et al., 1992)
        bab-I
        (Pointud et al., 1999, Pointud, 1998.9.23, Pointud et al., 1998)
        bab1
        (Camara et al., 2019, Shokri et al., 2019, Allbee et al., 2018, Bischof et al., 2018, Webber et al., 2018, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Massey and Wittkopp, 2016, Tsai et al., 2016, Dembeck et al., 2015, Schertel et al., 2015, Jiang and Singh, 2014, Rogers et al., 2014, Baanannou et al., 2013, Bastide et al., 2013, Devi et al., 2013, Li and Gilmour, 2013, Ohtani et al., 2013, Rogers et al., 2013, Spokony and White, 2013.7.5, Bartoletti et al., 2012, Kvon et al., 2012, Rojas-Ríos et al., 2012, Bickel et al., 2011, Chatterjee et al., 2011, Cherbas et al., 2011, Luo et al., 2011, McNeil et al., 2011, Nègre et al., 2011, Pruteanu-Malinici et al., 2011, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Bickel et al., 2009, Guo and Wang, 2009, Bickel et al., 2008, Randsholt and Santamaria, 2008, Williams et al., 2008, Bolivar et al., 2006, Jeong et al., 2006)
        bric-a-brac
        (Bonchuk et al., 2011, Eliazer and Buszczak, 2011)
        Name Synonyms
        Bric a brac
        (Dey et al., 2009)
        Bric a brac 1
        (Kim et al., 2010)
        Bric a brac1
        (Kaplow et al., 2007)
        Bric-a-brac
        (Bonchuk et al., 2011, Eliazer and Buszczak, 2011)
        bric a brac
        (Corsetti and Azpiazu, 2013, Carpenter et al., 2009, Keller, 2006, Lehmann, 2004, Wittkopp et al., 2003)
        bric a brac 1
        (Bickel et al., 2009, Burnette et al., 2005, Couderc et al., 2002)
        bric a brac I
        (Pointud, 1998.9.23, Pointud et al., 1998)
        bric-a-brac
        (Verhulst and van de Zande, 2015, Devi et al., 2013, Bickel et al., 2011, Gibert et al., 2011, Robinett et al., 2010, Ebacher et al., 2007, Gibert et al., 2007, Schlötterer et al., 2007, Garvey et al., 2005, Zarkower, 2001, Williamson and Lehmann, 1996)
        bric-a-brac 1
        (Bastide et al., 2013, Bolivar et al., 2006, Burnette et al., 2005)
        bric-a-brac1
        (Dembeck et al., 2015)
        Secondary FlyBase IDs
        • FBgn0035183
        • FBgn0061802
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        modENCODE_regulation_TFs
        Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
        References (194)