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General Information
Symbol
Dmel\bab1
Species
D. melanogaster
Name
bric a brac 1
Annotation Symbol
CG9097
Feature Type
FlyBase ID
FBgn0004870
Gene Model Status
Stock Availability
Gene Snapshot
bric a brac 1 (bab1) encodes a transcriptional regulator that functions partially redundantly with the product of bab2. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity. [Date last reviewed: 2019-03-07]
Also Known As
bab, bric-a-brac, bric a brac, bab-I, bric a brac I
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:1,036,369..1,101,089 [-]
Recombination map
3-0.5
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
Summaries
Gene Group (FlyBase)
PIPSQUEAK TRANSCRIPTION FACTORS -
Pipsqueak transcription factors are sequence-specific DNA binding proteins that regulate transcription. These family members are characterized by a heix-turn-helix DNA-binding domain called Psq domain, which consists of four tandem repeats of a conserved 50-amino acid sequence, the Psq motif. (Adapted from FBrf0148954 and FBrf0105267).
Protein Function (UniProtKB)
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.
(UniProt, Q9W0K7)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\bab1 or the JBrowse view of Dmel\bab1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.53
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0072642
5340
977
FBtr0333268
5319
970
FBtr0333269
5322
971
FBtr0333270
5337
976
Additional Transcript Data and Comments
Reported size (kB)
5.4 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0072538
103.3
977
8.25
FBpp0305466
102.6
970
8.25
FBpp0305467
102.7
971
8.25
FBpp0305468
103.3
976
8.25
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\bab1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:bip2; FB:FBgn0026262
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Biological Process (11 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from expression pattern
(assigned by UniProt )
inferred from expression pattern
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:abd-A; FB:FBgn0000014
inferred from genetic interaction with FLYBASE:Abd-B; FB:FBgn0000015
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Transcript expression in the ovary is restricted to the cells that form the terminal filaments. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs.
Within the leg imaginal disc, the bab transcript is detected in the primordia for tarsal segments 2 to 4 and the distal margin of tarsal segment 1.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
The bab protein is located in the nucleus.
Two cis regulatory elements govern bab1 expression in the pupal abdomen: one element that regulates bab1 expression in segments A2–A4 of both sexes and a second, dimorphic element that regulates expression in the posterior segments A5–A7 of females.
Protein expression in the ovary is restricted to the cells that form the terminal filaments.Protein is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs. This expression is graded with highest expression in TS3 and TS4 and lower expression in TS1 and TS2 as per FBrf0065404.In the female genital disc strongest protein expression is observed in the vaginal plate primordium and the A8 tergite.In the male genital disc strongest protein expression is observed in a region of the male genital primordium.bab1-expressing cells are found in the central brain hemisphers and the thoracic ganglia.
Starting in larval mid-third instar, lacZ expression is detected in a concentric domain in leg and antennal imaginal discs. These expression domains correspond to the primordia of the tarsus, and subdistal structures of the antenna, respectively. By late third larval instar, expression is stronger, and the primordia of tarsal segments 2 to 4, and of the distal portion of tarsal segment 1, are stained. The expression displays a graded and wave-like pattern: tarsal folds 3 and 4 stain more than folds 1 and 2, and the ridges of the folds stain more than the furrows. This staining pattern is still visible in 6 hour-old prepupae. In adults, staining is seen in two segments of the antennal basal cylinder.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Expression Deduced from Reporters
Reporter: P{A92}bab1A30
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{A92}bab1P
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1Agal4-5
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1Gal4
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1Pgal4-2
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GawB}bab1
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\bab1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 35 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of bab1
Transgenic constructs containing regulatory region of bab1
Deletions and Duplications ( 9 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
2 of 15
Yes
Yes
2 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
No
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (2)
1 of 13
Yes
No
1 of 13
Yes
No
Xenopus tropicalis (Western clawed frog) (2)
1 of 12
Yes
Yes
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
1 of 15
Yes
No
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904IH )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505F0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03II )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ABC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0WNB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (23)
4 of 10
4 of 10
4 of 10
4 of 10
4 of 10
4 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
2 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-0.5
    Cytogenetic map
    Sequence location
    3L:1,036,369..1,101,089 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    61E2-61F1
    Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    61F1-61F3
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (24)
    Genomic Clones (47)
    cDNA Clones (36)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Source for merge of: bab1 anon-WO0118547.639
        Source for merge of: bab CG13910
        Additional comments
        "fap" (female abdomen pattern) is very likely to correspond to the "bab" locus (which is composed of the paralogous "bab1" and "bab2" genes).
        Annotations CG9097 and CG13910 merged as CG9097 in release 3 of the genome annotation.
        Source for merge of bab1 anon-WO0118547.639 was sequence comparison ( date:051113 ).
        Other Comments
        DNA-protein interactions: genome-wide binding profile assayed for bab1 protein in 0-12 hr embryos; see mE1_TFBS_bab1 collection report.
        bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2.
        Pigmentation patterns specified by bab1 affect mating preferences, suggesting that sexual selection has contributed to the evolution of bab1 regulation.
        bab1 expression is modulated segment- and sex-specifically in sexually dimorphic species but is uniform in sexually monomorphic species.
        bab1 integrates regulatory inputs from the homeotic and sex-determination pathways to control sexually dimorphic abdominal pigmentation and segment morphology.
        bab1 is required for the formation of the terminal filaments in the third larval instar ovary. The N terminal region of the protein encodes for a regulator of gene expression that contains the BTB domain.
        bab1 is cell autonomously required for the formation of terminal filaments and is crucial for the normal morphogenesis of the ovary.
        bab1 is necessary for terminal filament cluster formation which is required in turn for ovariole morphogenesis to take place.
        bab1 function is dosage-dependent and is required in a graded manner for the specification of tarsal segments. This and its expression pattern suggests that bab1 function may specify segment identity in the tarsus. Strong mutants and deletions for bab1 show a temperature-sensitive haploinsufficient dominant phenotype.
        Mutations in bab1 disrupt the formation of the terminal filaments in larval ovaries and cause severe disorganised adult ovaries. bab1 has been cloned and shown to be expressed in the terminal filament cells.
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 57 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (20)
        Reported As
        Symbol Synonym
        CG13910
        anon-WO0118547.639
        Secondary FlyBase IDs
        • FBgn0035183
        • FBgn0061802
        Datasets (1)
        Study focus (1)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
        References (194)