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Gene Dmel\bab1

General Information
Symbol	Dmel\bab1	Species	D. melanogaster
Name	bric a brac 1	Annotation symbol	CG9097
Feature type	protein_coding_gene	FlyBase ID	FBgn0004870
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	bab, bab-I
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61E2-61F1	Sequence location	3L:1,036,369..1,101,089 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene bric a brac 1 is referred to in FlyBase by the symbol Dmel\bab1 (CG9097, FBgn0004870). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; AT DNA binding. There is experimental evidence that it is involved in the biological process: female gonad development; eye-antennal disc morphogenesis; transcription, DNA-dependent; sex differentiation; imaginal disc-derived leg morphogenesis. 33 alleles are reported. The phenotypes of these alleles are annotated with: adult segment; organ system subdivision; appendage segment; organ system; thoracic segment; vitellarium; sense organ; prothoracic leg; cell cluster organ; metatarsus. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; DNA binding HTH domain, Psq-type; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Comments on Affy2 ProbeSet: ProbeSet 1623466_at completely aligns to an exonic region of only a subset of 1 of the 2 FlyBase-annotated transcript isoforms of bab1. Gene sequence location is 3L:1036369..1101089.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61E2-61F1   Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640
Experimentally Determined Cytological Location
Cytogenetic map Notes References 61F1-61F3   (determined by in situ hybridisation)   (Godt et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\bab1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) bab1-RA FBtr0072643  NM_206229   2600   526 bab1-RB FBtr0072642  NM_167852   5340   977 bab1-RC FBtr0333268  NM_001274310   5319   970 bab1-RD FBtr0333269  NM_001274311   5322   971 bab1-RE FBtr0333270  NM_001274312   5337   976
Additional Transcript Data & Comments
Reported size (kB)	5.4 (northern blot) (Couderc et al., 2002)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein bab1-PA   FBpp0089114   55.7   526   6.99     NP_995951   AAS64927 bab1-PB   FBpp0072538   103.3   977   8.25     NP_728565   AAF47439 bab1-PC   FBpp0305466   102.6   970   8.25     NP_001261239   AGB93934 bab1-PD   FBpp0305467   102.7   971   8.25     NP_001261240   AGB93935 bab1-PE   FBpp0305468   103.3   976   8.25     NP_001261241   AGB93936
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) DNA binding HTH domain, Psq-type (IPR007889) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Homeodomain-like (IPR009057)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140795   AA141417   AA141619   AA141698   AA141745   AA142000   AA142125   AA695666   AE014296 AAF47439   AE014296 AAS64927   AE014296 AGB93934   AE014296 AGB93935   AE014296 AGB93936   AJ252081   AJ252082 CAB64385   AX094515   AY095181   AY122075 AAM52587   BF501923   BG637901   BG640013   BH900991   BH900992   BI239344   BI239355   BI367459   BI572109   BI573351   BI573352   BI592783   BI606465   BI609295   CK135864   CO176870   CO196145   CO270868   CO271834   CO283373   CO284272   CO284580   CO285477   CO290439   CO296225   CO319335   CO327476   CO338463   CO339878   CO340064   CO340329   CZ467432   CZ484234   CZ484235   CZ485224   CZ490382   U01333 AAA87052
UniProtKB/Swiss-Prot	Q9W0K7
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000161027 3L:1,085,981..1,086,000 bound_moiety=bab1-XP evidence=experimental (Bergman et al., 2005, Lours et al., 2003) protein binding site FBsf0000161028 3L:1,086,093..1,086,117 bound_moiety=bab1-XP evidence=experimental (Bergman et al., 2005, Lours et al., 2003) protein binding site FBsf0000161029 3L:1,085,801..1,085,820 bound_moiety=bab1-XP evidence=experimental (Lours et al., 2003, Bergman et al., 2005) protein binding site FBsf0000161030 3L:1,085,772..1,085,786 bound_moiety=bab1-XP evidence=experimental (Bergman et al., 2005, Lours et al., 2003) regulatory region FBsf0000435030 3L:1,096,651..1,098,007 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000435275 3L:1,085,113..1,085,477 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000435760 3L:1,096,879..1,099,116 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000435861 3L:1,084,947..1,085,399 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000436004 3L:1,084,814..1,085,477 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000436037 3L:1,084,814..1,085,194 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000436778 3L:1,089,347..1,096,414 evidence=Reporter construct (in vivo) (Williams et al., 2008, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) third instar larval stage   ventral thoracic disc | restricted   (Couderc et al., 2002) wandering third instar larval stage   eye-antennal disc | restricted   (Godt et al., 1993) third instar larval stage L2   ventral thoracic disc | restricted   (Godt et al., 1993) prepupal stage   ovary | restricted   (Couderc et al., 2002)
Additional Descriptive Data
	Transcript expression in the ovary is restricted to the cells that form the terminal filaments. Transcript is expressed in the primordium of tarsal segments TS1-TS4 in leg imaginal discs. (Couderc et al., 2002) Within the leg imaginal disc, the bab2 transcript is detected in the primordia for tarsal segments 2 to 4 and the distal margin of tarsal segment 1. (Godt et al., 1993)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   ventral thoracic disc | restricted   (Godt et al., 1993, Couderc et al., 2002) eye-antennal disc | restricted   (Godt et al., 1993) wandering third instar larval stage   male genital disc | restricted   (Couderc et al., 2002) female genital disc | restricted   (Couderc et al., 2002) embryonic/larval central nervous system | restricted   (Couderc et al., 2002) prepupal stage   tarsal segment   (Godt et al., 1993) central nervous system | restricted   (Couderc et al., 2002) prepupal stage P1   ovary | restricted   (Couderc et al., 2002) Comment:puparium formation
Additional Descriptive Data
	The bab2 protein is located in the nucleus. (Couderc et al., 2002, Godt et al., 1993) Two cis regulatory elements govern bab1 expression in the pupal abdomen: one element that regulates bab1 expression in segments A2–A4 of both sexes and a second, dimorphic element that regulates expression in the posterior segments A5–A7 of females. (Williams et al., 2008) Starting in larval mid-third instar, Ecol\lacZ expression is detected in a concentric domain in leg and antennal imaginal discs. These expression domains correspond to the primordia of the tarsus, and subdistal structures of the antenna, respectively. By late third larval instar, expression is stronger, and the primordia of tarsal segments 2 to 4, and of the distal portion of tarsal segment 1, are stained. The expression displays a graded and wave-like pattern: tarsal folds 3 and 4 stain more than folds 1 and 2, and the ridges of the folds stain more than the furrows. This staining pattern is still visible in 6 hour-old prepupae. In adults, staining is seen in two segments of the antennal basal cylinder. (Godt et al., 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Couderc et al., 2002)
Expression Deduced from Reporters
Reporter: P{A92}bab1P Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   antennal disc   (Godt et al., 1993) ventral thoracic disc   (Godt et al., 1993) Reporter: P{GawB}bab1 Stage Tissue/Position (including subcellular localization) Reference larval stage   ventral thoracic disc | restricted   (Azpiazu and Morata, 2002) Reporter: P{lArB}bab1A128.1F3 Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval hindgut   (Bellen et al., 1989) metameric furrow   (Bellen et al., 1989) embryonic/larval proventriculus   (Bellen et al., 1989) anal pad | presumptive   (Bellen et al., 1989) embryonic/larval digestive system | restricted   (Bellen et al., 1989) larval stage   ventral thoracic disc | restricted   (Mukherjee et al., 2000) third instar larval stage   antennal disc | restricted   (Godt et al., 1993) ventral thoracic disc | restricted   (Godt et al., 1993) prepupal stage   ventral thoracic disc | restricted   (Godt et al., 1993) antennal disc | restricted   (Godt et al., 1993) adult stage   basal cylinder | restricted   (Godt et al., 1993)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    43.8 Larval Midgut    2.9 Larval Hindgut    3.7 Larval Malpighian Tubules    2.7 Larval Fat Body    9.6 Larval Salivary Gland    4.1 Larval Trachea    2.275 Larval Carcass    3.125 Adult Head    14.7 Adult Eye    11.575 Adult Brain    110.1 Adult Thoracic-Abdominal Ganglion    89.3 Adult Crop    40.1 Adult Midgut    8.2 Adult Hindgut    26.3 Adult Malpighian Tubules    6 Adult Fat Body    5.9 Adult Salivary Gland    5.5 Adult Heart    12.675 Adult VirginFemale Spermatheca    5.3 Adult InseminatedFemale Spermatheca    10.1 Adult Ovary    4.5 Adult Testis    5.4 Adult Male Accessory Gland    5.8 Adult Carcass    3.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    14.7   NA  Eye    11.575   NA  Brain    110.1   43.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    89.3   NA  Crop    40.1   2.9  Midgut    8.2   3.7  Hindgut    26.3   2.7  Malpighian Tubules    6   9.6  Fat Body    5.9   4.1  Salivary Gland    5.5   NA  Heart    no informative data   2.275  Trachea    NA   NA  VirginFemale Spermatheca    5.3   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    4.5   NA  Testis    5.4   NA  Male Accessory Gland    5.8   3.125  Carcass    3.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    7 central nervous system, pupae P8    10 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    2 head, mated 1-day male    3 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of very low expression. Peak expression observed at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    3 pupae 2d postWPP    2 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    1 ovary fGS/OSS    8 ovary OSC    5 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • AT17506 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004870 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9097-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI bab1Scer\UAS.cGa lethal, with Scer\GAL4p339 bab1Scer\UAS.cGa lethal, with Scer\GAL4T80 bab1Scer\UAS.cGa lethal | pupal stage, with Scer\GAL4pnr-MD237 bab1GD1233 partially lethal - majority die, with Scer\GAL4hs.PB bab1Scer\UAS.cGa Sterility Allele female sterile bab1P female sterile | partially | recessive bab1P female sterile | recessive bab1P bab1PR10 bab1PR11 bab1PR23 bab1PR24 bab1PR30 Other Phenotypes Allele body color defective | female bab1A128.1F3 bab1D1 body color defective | female | recessive bab1P visible | dominant | heat sensitive bab1PR10 bab1PR24 visible | recessive bab1PR10 bab1PR11 bab1PR23 bab1PR24 bab1PR30 Phenotype manifest in Allele abdominal tergite 5 | female bab1D1 abdominal tergite 6 | female bab1A128.1F3 bab1D1 bab1P abdominal tergite 7 | female bab1A128.1F3 bab1D1 bab1P antenna bab1PR10 bab1PR11 bab1PR23 bab1PR24 bab1PR30 basal cylinder bab1PR10 bab1PR24 germarium bab1P leg bab1PR10 bab1PR11 bab1PR23 bab1PR24 bab1PR30 macrochaeta bab1PR10 bab1PR24 macrochaeta, with Scer\GAL4hs.PB bab1Scer\UAS.cGa mesothoracic tarsal segment 2 bab1PR10 bab1PR24 mesothoracic tarsal segment 3 bab1PR10 bab1PR24 mesothoracic tarsal segment 4 bab1PR10 bab1PR24 mesothoracic tarsal segment 5 bab1PR10 bab1PR24 metathoracic tarsal segment 2 bab1PR10 bab1PR24 metathoracic tarsal segment 3 bab1PR10 bab1PR24 metathoracic tarsal segment 4 bab1PR10 bab1PR24 metathoracic tarsal segment 5 bab1PR10 bab1PR24 ovariole bab1P ovary bab1P bab1PR10 bab1PR11 bab1PR23 bab1PR24 bab1PR30 prothoracic tarsal segment 2 bab1PR10 bab1PR11 bab1PR23 bab1PR24 bab1PR30 prothoracic tarsal segment 3 bab1PR10 bab1PR24 prothoracic tarsal segment 4 bab1PR10 bab1PR24 prothoracic tarsal segment 5 bab1PR10 bab1PR24 sex comb bab1PR24 sex comb | ectopic bab1PR10 bab1PR11 bab1PR24 bab1PR30 tergite, with Scer\GAL4hs.PB bab1Scer\UAS.cGa terminal filament bab1P bab1PR24
Classical Alleles ( 28 )
For All Classical Alleles Show
Allele of bab1 Class Mutagen Stocks Known lesion bab1Agal4-5 Delta2-3 gene conversion 1 Yes bab1Ar07 P-element activity 1 -- bab1c01178 1 -- bab1c01773 piggyBac transposase 1 -- bab1f01763 piggyBac transposase 1 -- bab1f02681 piggyBac transposase 1 -- bab1KG08154 P-element activity 1 -- bab1MB01041 1 -- bab1MB01972 1 -- bab1MI02308 1 -- bab1Pgal4-2 Delta2-3 gene conversion 1 Yes bab1A128.1F3 P-element activity 0 Yes bab1A30 P-element activity 0 Yes bab1Agal4-4 Delta2-3 gene conversion 0 Yes bab1Agal4-6 Delta2-3 gene conversion 0 Yes bab1D1 0 -- bab1f07645 piggyBac transposase 0 -- bab1Fpa2 gamma ray 0 Yes bab1Gal4 gene conversion Delta2-3 0 Yes bab1P hypomorphic allele - genetic evidence Delta2-3 0 Yes bab1Pgal4-1 Delta2-3 gene conversion 0 Yes bab1PR10 hypomorphic allele - genetic evidence Delta2-3 0 -- bab1PR11 hypomorphic allele - genetic evidence Delta2-3 0 -- bab1PR23 hypomorphic allele - genetic evidence Delta2-3 0 -- bab1PR24 hypomorphic allele - genetic evidence Delta2-3 0 -- bab1PR30 hypomorphic allele - genetic evidence Delta2-3 0 -- bab1PR72 Delta2-3 0 -- bab1PRDS Delta2-3 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of bab1 Class Mutagen Stocks Known lesion bab1GD1233 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes bab1GD16870 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes bab1Scer\UAS.cGa in vitro construct - regulatory fusion 2 Yes bab1GLV21072 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes bab1KK111761 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Ar12-1 (Llopart et al., 2002) Df(3L)babAr07 (Kopp et al., 2000) Df(3L)babPR72 (Couderc et al., 2002) Df(3L)babPRDS (Couderc et al., 2002) Df(3L)bab-PG (Godt et al., 1993) Df(3L)Fpa1 (Couderc et al., 2002) Df(3L)Fpa2 (Couderc et al., 2002) Ts(YSt;3Rt)A114 (Godt et al., 1993)
Not disrupted in	Df(3L)Ar11 (Llopart et al., 2002)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1233} NA P{GD16870} NA P{KK111761} NA P{TRiP.GLV21072} NA P{UAS-bab1.G} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}bab1MI02308 NA P{SUPor-P}bab1KG08154 NA PBac{PB}bab1c01178 NA PBac{PB}bab1c01773 NA PBac{WH}bab1f01763 NA PBac{WH}bab1f02681 NA PBac{WH}bab1f07645 NA insertion of enhancer trap P{A92}bab1A30 No P{A92}bab1P No P{lArB}bab1A128.1F3 No insertion of enhancer trap binary system Mi{ET1}bab1MB01041 No Mi{ET1}bab1MB01972 No P{GawB}bab1Agal4-4 No P{GawB}bab1Agal4-5 No P{GawB}bab1Agal4-6 No P{GawB}bab1Gal4 No P{GawB}bab1Pgal4-1 No P{GawB}bab1Pgal4-2 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
AT DNA binding inferred from direct assay (Lours et al., 2003) protein binding inferred from physical interaction with bip2 (Pointud et al., 2001)
Biological Process
CV term Evidence References
eye-antennal disc morphogenesis inferred from expression pattern (assigned by UniProtKB) (Couderc et al., 2002) female gonad development inferred from genetic interaction with bab2 AND inferred from mutant phenotype (assigned by UniProtKB) (Couderc et al., 2002) imaginal disc-derived leg morphogenesis inferred from genetic interaction with bab2 AND inferred from mutant phenotype (assigned by UniProtKB) (Couderc et al., 2002) sex differentiation inferred from genetic interaction with Abd-B AND inferred from genetic interaction with abd-A AND inferred from mutant phenotype (Kopp et al., 2000) transcription, DNA-dependent inferred from expression pattern (assigned by UniProtKB) (Couderc et al., 2002)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Couderc et al., 2002)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
DNA binding non-traceable author statement (Lehmann, 2002.7.1) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity (FlyBase, 1992-) traceable author statement (Christiansen et al., 2002)
Biological Process
CV term Evidence References
female sex differentiation traceable author statement (Billeter et al., 2002) negative regulation of developmental pigmentation traceable author statement (Christiansen et al., 2002) negative regulation of male pigmentation non-traceable author statement (Billeter et al., 2002) regulation of developmental pigmentation traceable author statement (Simpson, 2002) regulation of transcription, DNA-dependent traceable author statement (Christiansen et al., 2002) sex differentiation traceable author statement (Christiansen et al., 2002) sex-specific pigmentation traceable author statement (Simpson, 2002, Zarkower, 2001, Sanchez and Guerrero, 2001) transcription, DNA-dependent inferred from sequence or structural similarity (FlyBase, 1992-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions bab1 allele Gene References bab1Ar07 bab2 (Kopp et al., 2000, Chu et al., 2002, Couderc et al., 2002) bab1PR72 bab2 (Godt et al., 1993, Godt and Laski, 1995, Couderc et al., 2002) bab1PRDS bab2 (Godt et al., 1993, Godt and Laski, 1995, Couderc et al., 2002) unspecified abd-A (Kopp et al., 2000) Abd-B (Kopp et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63665 DroID - A comprehensive database of gene and protein interactions. • FBgn0004870 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38116 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9W0K7
Orthologs
OrthoDB Orthologs (85) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6T1J70 Dipteran inclusive ortholog search EOG62V8RH Insect inclusive ortholog search EOG6280X1 Arthropod inclusive ortholog search EOG608KQF Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6T1J70)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\bab1     Drosophila sechellia   Dsec\GM14240     Drosophila erecta   Dere\GG14626     Drosophila yakuba   Dyak\bab1     Drosophila ananassae   Dana\GF10081 Y   Drosophila persimilis   Dper\GL26926 Y
Orthologs in non-Drosophila Dipterans (EOG62V8RH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001739 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011216 Y
Orthologs in non-Dipteran Insects (EOG6280X1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47057 Y Apis mellifera Western honey bee  Amel\GB49382 Y Apis mellifera Western honey bee  Amel\GB41167 Y Apis mellifera Western honey bee  Amel\LOC725311 Y Apis mellifera Western honey bee  Amel\GB47059 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011566 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009116 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010467 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008240 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11228 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14438 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25151 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21314 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16281 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16282 Y Atta cephalotes Leafcutter ant  Acep\ACEP16657 Y Atta cephalotes Leafcutter ant  Acep\ACEP19771 Y Atta cephalotes Leafcutter ant  Acep\ACEP15239 Y Atta cephalotes Leafcutter ant  Acep\ACEP16653 Y Atta cephalotes Leafcutter ant  Acep\ACEP16670 Y Atta cephalotes Leafcutter ant  Acep\ACEP26315 Y Atta cephalotes Leafcutter ant  Acep\ACEP25847 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17419 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO13831 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO22974 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO19190 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO17933 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19143 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14972 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15302 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21900 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12465 Y Linepithema humile Argentine ant  Lhum\LH21661 Y Linepithema humile Argentine ant  Lhum\LH16826 Y Linepithema humile Argentine ant  Lhum\LH13615 Y Linepithema humile Argentine ant  Lhum\LH21665 Y Linepithema humile Argentine ant  Lhum\LH19143 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11625 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24935 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11637 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11638 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB16867 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB11942 Y Solenopsis invicta Red fire ant  Sinv\SINV15582 Y Solenopsis invicta Red fire ant  Sinv\SINV16487 Y Solenopsis invicta Red fire ant  Sinv\SINV13243 Y Solenopsis invicta Red fire ant  Sinv\SINV13240 Y Solenopsis invicta Red fire ant  Sinv\SINV15809 Y Solenopsis invicta Red fire ant  Sinv\SINV13628 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004381 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002482 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI087848 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004069 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001210 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007530 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007531 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012231 Y Pediculus humanus Human body louse  Phum\PHUM595780 Y Pediculus humanus Human body louse  Phum\PHUM228760 Y Pediculus humanus Human body louse  Phum\PHUM088440 Y Pediculus humanus Human body louse  Phum\PHUM088430 Y Pediculus humanus Human body louse  Phum\PHUM489940 Y Pediculus humanus Human body louse  Phum\PHUM537020 Y Tribolium castaneum Red flour beetle  Tcas\TC009535 Y Tribolium castaneum Red flour beetle  Tcas\TC013842 Y Tribolium castaneum Red flour beetle  Tcas\TC013843 Y Tribolium castaneum Red flour beetle  Tcas\GLEAN_07162 Y Tribolium castaneum Red flour beetle  Tcas\TC003621 Y
Orthologs in non-Insect Arthropods (EOG608KQF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ACSBG1 Y Daphnia pulex Water flea  Dpux\Sld5 Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\JGI_V11_347243 Y Daphnia pulex Water flea  Dpux\TwdlJ Y Ixodes scapularis Deer tick  Isca\ISCW016371 Y Ixodes scapularis Deer tick  Isca\ISCW010367 Y Ixodes scapularis Deer tick  Isca\ISCW016996 Y Ixodes scapularis Deer tick  Isca\ISCW019463 Y
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (4) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila ananassae Dana\GF10081 Drosophila pseudoobscura pseudoobscura Dpse\GA28608 Drosophila persimilis Dper\GL26926 Drosophila willistoni Dwil\GK16863
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	6939 w*; P{UAS-bab1.G}1-2 6804 w*; P{UAS-bab1.G}46-49
Harvard	- PBac{PB}bab1c01178 - PBac{PB}bab1c01773 - PBac{WH}bab1f01763 - PBac{WH}bab1f02681
VDRC	v106110 P{KK111761}VIE-260B v6960 w1118; P{GD1233}v6960 v6961 w1118; P{GD1233}v6961 v24496 w1118; P{GD1233}v24496 v50286 w1118; P{GD16870}v50286 v50285 w1118; P{GD16870}v50285/CyO
	More stocks available...
Genomic Clones ( 3 )
	BACR02N23 BACR22D12 BACR27E18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 37 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT17506 GM07634
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM03224 LD07807 RE35814 RE35826 RE53229 RH07461 RH10564 RH14057 RH72954 SD02313 SD10309
Other clones	CK00110 CK00276 CK01013 CK01710 CK02129 CK02242 CK02431 EK001146 EK051431 EK074010 EK100806 EK104826 EK162951 EK165633 EK166337 EK169053 EK213058 EK277654 EN16847 EP07313 EP09547 EP09949 EP10433 RH09017
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004870 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38116
Antibody Information
	polyclonal (Godt et al., 1993, Williams et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: bab1 anon-WO0118547.639 (FlyBase, 1996-) Source for merge of: bab CG13910 (FlyBase Genome Annotators, 2002-2003)
Additional comments	"fap" (female abdomen pattern) is very likely to correspond to the "bab" locus (which is composed of the paralogous "bab1" and "bab2" genes). (Couderc et al., 2002) Annotations CG9097 and CG13910 merged as CG9097 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of bab1 anon-WO0118547.639 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for bab1 protein in 0-12 hr embryos; see mE1_TFBS_bab1 collection report. (Negre et al., 2011) bab1 and bab2 are both required for normal development. The functions of bab1 and bab2 show both redundant and divergent aspects, with bab2 playing a predominant role in exerting "bab" function. Both bab1 and bab2 are required for normal ovarian development, but loss-of-function of bab2 causes a more severe ovarian phenotype. There is an overlapping but differential requirement for bab1 and bab2 in the pigmentation of different adult abdominal segments, with A7 being more dependent on bab1 and A5 being more dependent on bab2 activity. Only bab2 plays an essential role in leg development; a bab1 mutant does not cause a mutant leg phenotype, whereas even weak bab2 mutants show leg defects. The strongest defects in ovaries, legs and abdomen that are associated with the "bab" locus are only seen in mutants that are null for both bab1 and bab2. (Couderc et al., 2002) bab1 integrates regulatory inputs from the homeotic and sex-determination pathways to control sexually dimorphic abdominal pigmentation and segment morphology. (Kopp et al., 2000) Pigmentation patterns specified by bab1 affect mating preferences, suggesting that sexual selection has contributed to the evolution of bab1 regulation. (Kopp et al., 2000) bab1 expression is modulated segment- and sex-specifically in sexually dimorphic species but is uniform in sexually monomorphic species. (Kopp et al., 2000) bab1 is required for the formation of the terminal filaments in the third larval instar ovary. The N terminal region of the protein encodes for a regulator of gene expression that contains the BTB domain. (Couderc et al., 1995) bab1 is cell autonomously required for the formation of terminal filaments and is crucial for the normal morphogenesis of the ovary. (Godt and Laski, 1995) bab1 is necessary for terminal filament cluster formation which is required in turn for ovariole morphogenesis to take place. (Sahut-Barnola et al., 1995) bab1 function is dosage-dependent and is required in a graded manner for the specification of tarsal segments. This and its expression pattern suggests that bab1 function may specify segment identity in the tarsus. Strong mutants and deletions for bab1 show a temperature-sensitive haploinsufficient dominant phenotype. (Godt et al., 1993) Mutations in bab1 disrupt the formation of the terminal filaments in larval ovaries and cause severe disorganised adult ovaries. bab1 has been cloned and shown to be expressed in the terminal filament cells. (Godt et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_167852 NM_206229 NM_001274310 NM_001274311 NM_001274312 RefSeq (Proteins) • NP_728565 NP_995951 NP_001261239 NP_001261240 NP_001261241 DDBJ / EMBL / GenBank • AAA87052 AAF47439 AAM52587 AAS64927 AGB93934 AGB93935 AGB93936 AJ252081 AJ252082 AX094515 AY122075 BF501923 BH900991 BH900992 CAB64385 CZ467432 CZ484234 CZ484235 CZ485224 CZ490382 U01333 Entrez Gene - A searchable database of RefSeq genes. • 38116 UniProtKB/Swiss-Prot • Q9W0K7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) DNA binding HTH domain, Psq-type (IPR007889) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Homeodomain-like (IPR009057) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • AT17506
Linkouts
	BioGRID - A database of protein and genetic interactions • 63665 DroID - A comprehensive database of gene and protein interactions. • FBgn0004870 DRSC - Results from RNAi screens. • FBgn0004870 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004870 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9097-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004870 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38116 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/bricabk1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38116 modMine - Data generated by the modENCODE project. • FBgn0004870 REDfly - A database of transcriptional regulatory elements. • FBgn0004870 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9W0K7
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-WO0118547.639   bab (Hatini et al., 2005, Cummins et al., 2003, Wittkopp et al., 2003, Christiansen et al., 2002, Simpson, 2002, Chen et al., 2001, Kopp et al., 2003, Galindo et al., 2002, Williams et al., 2003, Bray and de Celis Ibeas, 2003, Burtis, 2002, Panganiban and Rubenstein, 2002, Galindo et al., 2002, Siegmund and Lehmann, 2002, Chu et al., 2002, St Pierre et al., 2002, Shim et al., 2001, Kopp et al., 2001, Gibson and Palsson, 2001, Bopp, 2001, Stern, 2000, Kopp et al., 2000, Galindo and Couso, 2000, Mukherjee et al., 2000, King and Lin, 1999, Couso and Bishop, 1998, Santamaria, 1998, Duncan et al., 1998, Chen et al., 1997, Buratovich and Bryant, 1997, Aplin and Kaufman, 1997, Cavarec et al., 1997, Yamamoto et al., 1996, Ito et al., 1996, Weber et al., 1995, Sahut-Barnola et al., 1995, Chen et al., 1995, Godt and Laski, 1995, Couderc et al., 1995, Zollman et al., 1994, Godt and Laski, 1995, Godt et al., 1993, Godt et al., 1992, Kelly and Daniel, 2006, Schloetterer et al., 2007, Keller, 2006, Jeong et al., 2006, Ebacher et al., 2007, Galindo et al., 2005, Gibert et al., 2007, Gibert et al., 2011, True et al., 2001, Robinett et al., 2010, Bosch et al., 2010, Pueyo and Couso, 2011) BAB (Dey et al., 2009) BAB1 (Pointud et al., 2001, Kim et al., 2010) bab1 (Jeong et al., 2006, Luo et al., 2011, Bickel et al., 2008, Bolivar et al., 2006, Nègre et al., 2011, Williams et al., 2008, Guo and Wang, 2009, Bickel et al., 2011, Cherbas et al., 2011, Chatterjee et al., 2011, The modENCODE Consortium, 2010, The modENCODE Consortium, 2010, Pruteanu-Malinici et al., 2011, Bickel et al., 2009, Randsholt and Santamaria, 2008, McNeil et al., 2011, Kvon et al., 2012) Bab1 (Deloger et al., 2009) bab-I (Pointud et al., 1999, Pointud, 1998.9.23, Pointud et al., 1998) bric-a-brac (Bonchuk et al., 2011) CG9097 (Deloger et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CG13910
Name Synonym	bric-a-brac (Garvey et al., 2005, Zarkower, 2001, Williamson and Lehmann, 1996, Schloetterer et al., 2007, Ebacher et al., 2007, Gibert et al., 2007, Gibert et al., 2011, Robinett et al., 2010, Bickel et al., 2011) bric a brac (Lehmann, 2004, Wittkopp et al., 2003, Keller, 2006, Carpenter et al., 2009) Bric a brac (Dey et al., 2009) bric a brac 1 (Couderc et al., 2002, Bickel et al., 2009) bric-a-brac 1 (Burnette et al., 2005, Bolivar et al., 2006) Bric a brac 1 (Kim et al., 2010) Bric a brac1 (Kaplow et al., 2007) bric a brac I (Pointud, 1998.9.23, Pointud et al., 1998)
Secondary FlyBase IDs
	FBgn0035183 FBgn0061802
References ( 136 )
Generate a list of	All references relating to this gene ( 136 )
List References by type	Research paper  ( 66 ) Supplementary material  ( 7 ) Review  ( 20 ) Erratum  ( 1 ) Retraction  ( 1 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 17 ) FlyBase analysis  ( 4 ) Patent  ( 1 ) Website  ( 1 ) Letter  ( 2 ) Curated genome annotation  ( 2 )
Recent research papers ( 14 )
	Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Kvon et al., 2012, Genes Dev. 26(9): 908--913 HOT regions function as patterned developmental enhancers and have a distinct cis-regulatory signature. [FBrf0218184] Rojas-Ríos et al., 2012, PLoS Biol. 10(4): e1001298 Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. [FBrf0218031] Bickel et al., 2011, PLoS Genet. 7(1): e1001275 Composite Effects of Polymorphisms near Multiple Regulatory Elements Create a Major-Effect QTL. [FBrf0212845] Bonchuk et al., 2011, J. Mol. Biol. 412(3): 423--436 Drosophila BTB/POZ Domains of "ttk Group" Can Form Multimers and Selectively Interact with Each Other. [FBrf0215054] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Cherbas et al., 2011, Genome Res. 21(2): 301--314 The transcriptional diversity of 25 Drosophila cell lines. [FBrf0213077] Gibert et al., 2011, PLoS Genet. 7(1): e1001280 Segregating Variation in the Polycomb Group Gene cramped Alters the Effect of Temperature on Multiple Traits. [FBrf0212864] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] McNeil et al., 2011, G3 (Bethesda) 1(5): 343--351 Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. [FBrf0217624] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Pruteanu-Malinici et al., 2011, PLoS Comput. Biol. 7(7): e1002098 Automatic Annotation of Spatial Expression Patterns via Sparse Bayesian Factor Models. [FBrf0214618] Pueyo and Couso, 2011, Dev. Biol. 355(2): 183--193 Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. [FBrf0213970] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...