uring oogenesis Encore physically interacts with the proteasome, protein degradation factor Cul1 and Cyclin E - in mutant germaria Cyclin E degradation is compromised, thus impairing exit from cystoblast cell divison
Transposon inserted in intron (7th intron)
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.46
8.0, 7.0 (northern blot)
1548 (aa); 230 (kD observed); 170 (kD predicted)
Interacts with hfp; however, given the nuclear localization of hfp, the relevance of such interaction is unclear. Interacts with CycE, Cul1, and the SCF-proteasome complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\enc using the Feature Mapper tool.
enc is detected in all of the germline cells of the germarium, and begins to accumulate preferentially in the future oocyte shortly after the formation of the 16 cell cyst. enc is transiently localized posteriorly in the oocyte at mid-oogenesis, but is anteriorly localized by stage 9, and is more concentrated in the dorsal side of the oocyte, above the oocyte nucleus. The distribution of enc protein at stage 9 is similar to the distribution of grk mRNA and protein. In spermatogenesis, enc protein is detected at the tip of the testis, where germline mitosis occurs.
GBrowse - Visual display of RNA-Seq signalsView Dmel\enc in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
enc is involved both in regulating the number of germline mitoses and in the process of oocyte differentiation. Mutations in enc result in exactly one round of mitosis in the germline and also affect the process of oocyte differentiation. These two phenotypes represent two independent requirements for enc during oogenesis. Disruption of bam expression in enc mutant ovaries suggests enc has a role early in cyst development.
Egg chambers from enc females produce egg chambers that contain on average 31 nurse cells and one oocyte. enc is also required later in oogenesis for correct dorsal ventral patterning in the egg. enc is a negative regulator of bam in the additional cells and the mitotic defect occurs at the beginning of the normal division program.