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Gene Dmel\cdi

General Information
Symbol	Dmel\cdi	Species	D. melanogaster
Name	center divider	Annotation symbol	CG6027
Feature type	protein_coding_gene	FlyBase ID	FBgn0004876
Gene Model Status	Current	Stock availability	22 publicly available
Also Known As	l(3)07013, 91F, B9.3, cdi/TESK1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	91E4-91F1	Sequence location	3R:14,870,604..14,920,076 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene center divider is referred to in FlyBase by the symbol Dmel\cdi (CG6027, FBgn0004876). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: negative regulation of sevenless signaling pathway; embryonic development via the syncytial blastoderm; actin filament organization. 58 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; embryonic/first instar larval cuticle; embryonic head; embryonic segment; macrochaeta; intersegmental nerve; mesothoracic tergum; nervous system; segment; head. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1629473_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of cdi. Gene sequence location is 3R:14870604..14920076.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms actin filament organization negative regulation of sevenless signaling pathway apical part of cell cytoplasm
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91E4-91F1   Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91F1-91F3   (determined by in situ hybridisation)   (Lukacsovich et al., 2001) 91F-91F     (Matthews, 1999.3.31) 91F1-91F5   (determined by in situ hybridisation)   (Spradling et al., 1999) 91F-91F   (determined by in situ hybridisation)   (Matthews and Crews, 1999) 91F1-91F5   (determined by in situ hybridisation)   (Perrimon et al., 1996) 91F1-91F5     (BDGP Project Members, 1994-1999) 91F-91F   (determined by in situ hybridisation)   (Matthews and Crews, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cdi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated DGC clone GM10731 appears problematic: is 5' to the CDS, does not contain the CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cdi-RA FBtr0083716  NM_079677   5749   1213 cdi-RB FBtr0305321  NM_001260262   6607   942
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cdi-PA   FBpp0083130   130.0   1213   6.79     NP_524401   AAF55630 cdi-PB   FBpp0293864   100.6   942   6.50     NP_001247191   AFH06509
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA694801   AA803362   AE014297 AAF55630   AC006091   AF139811   AF139812 AAD43525   AE014297 AFH06509   AI108141   AI108215   AI109812   AI405131   AQ073910   AW940963   AW941354   AY060976 AAL28524   BF492395   BF493417   BF493418   BF495338   BF498411   BF498525   BF498909   BF499550   BG633542   BG635164   BI582955   BP544165   BP547660   BP551134   BP556592   BP556593   BT004492 AAO42656   BT120172   BT122186   CK132302   CL528284   CL844463   CO156162   CO195671   CO273913   CO275620   CO279545   CO281921   CO287295   CO296796   CO299124   CO301353   CO301357   CO301617   CO306056   CO306108   CO314504   CO318673   CO326028   CO326706   CO326762   CO328796   CO333257   CO333636   CO344672   CZ468420   CZ476785   CZ476786   CZ476947   CZ476948   CZ477656   CZ477847   CZ481189   CZ481511   CZ481512   CZ483603   CZ483604   CZ484457   CZ485948   CZ485949   CZ488481   CZ488833   CZ490392   EC051488   EC052525   EC053479   EC053940   EC055487   EC055911   EC055920   EC058258   EC062538   EC064322   EC073977   EC077902   EC079396   EC079710   EC088724   EC089709   EC202883   EC205363   EC205970   EC216759   EC220869   EC226227   EC227609   EC232771   EC240444   EC243317   EC245683   EC253797   EC255129   EC256862   EC257986   EC262099   EV585906   EV592305   EV599212   G00601
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VE06 Q95S32 Q9Y1A8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
RT-PCR Stage Tissue/Position (including subcellular localization) Reference adult stage | male   testis   (Raymond et al., 2004)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical part of cell inferred from direct assay (Sese et al., 2006) cytoplasm inferred from direct assay (Sese et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye    755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye  (755.15) Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye    755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye    755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye    755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye  755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye    755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    393.25 Larval Midgut    177.6 Larval Hindgut    142 Larval Malpighian Tubules    63.5 Larval Fat Body    9 Larval Salivary Gland    14.1 Larval Trachea    23.6 Larval Carcass    20.975 Adult Head    227.2 Adult Eye    755.15 Adult Brain    291.4 Adult Thoracic-Abdominal Ganglion    263.1 Adult Crop    29.9 Adult Midgut    163 Adult Hindgut    101.8 Adult Malpighian Tubules    53.2 Adult Fat Body    10.2 Adult Salivary Gland    140.9 Adult Heart    25.45 Adult VirginFemale Spermatheca    19.3 Adult InseminatedFemale Spermatheca    19.6 Adult Ovary    6.8 Adult Testis    9.7 Adult Male Accessory Gland    64.3 Adult Carcass    56.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    227.2   NA  Eye    755.15   NA  Brain    291.4   393.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    263.1   NA  Crop    29.9   177.6  Midgut    163   142  Hindgut    101.8   63.5  Malpighian Tubules    53.2   9  Fat Body    10.2   14.1  Salivary Gland    140.9   NA  Heart    25.45   23.6  Trachea    NA   NA  VirginFemale Spermatheca    19.3   NA  InseminatedFemale Spermatheca    19.6   NA  Ovary    6.8   NA  Testis    9.7   NA  Male Accessory Gland    64.3   20.975  Carcass    56.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    28 testis, mated 4-day male    39 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (34) ovary, mated 4-day female  (28) testis, mated 4-day male  (39) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    28 testis, mated 4-day male    39 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    28 testis, mated 4-day male    39 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    28 testis, mated 4-day male    39 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female  (34) ovary, mated 4-day female  28 testis, mated 4-day male  (39) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    28 testis, mated 4-day male    39 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    20 central nervous system, pupae P8    17 head, virgin 1-day female    9 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    6 head, mated 1-day male    13 head, mated 4-day male    13 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    15 digestive system, larvae L3 wandering    17 digestive system, 1-day adult    21 digestive system, 4-day adult    25 digestive system, 20-day adult    23 fat body, larvae L3 wandering    2 fat body, white prepupae    10 fat body, pupae P8    11 carcass, larvae L3 wandering    13 carcass, 1-day adult    7 carcass, 4-day adult    10 carcass, 20-day adult    7 ovary, virgin 4-day female    34 ovary, mated 4-day female    28 testis, mated 4-day male    39 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    45 pupae 2d postWPP    40 pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day    29 adult male 05day    38 adult male 30day    34 adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40) embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr  (28) embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr  (27) embryo 16-18hr  (30) embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new  (31) white prepupae 12hr  (38) white prepupae 24hr  (45) pupae 2d postWPP  (40) pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day  (29) adult male 05day  (38) adult male 30day  (34) adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    45 pupae 2d postWPP    40 pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day    29 adult male 05day    38 adult male 30day    34 adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    45 pupae 2d postWPP    40 pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day    29 adult male 05day    38 adult male 30day    34 adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    45 pupae 2d postWPP    40 pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day    29 adult male 05day    38 adult male 30day    34 adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40) embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr  28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr  27 embryo 16-18hr  30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new  31 white prepupae 12hr  (38) white prepupae 24hr  (45) pupae 2d postWPP  (40) pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day  29 adult male 05day  (38) adult male 30day  (34) adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    45 pupae 2d postWPP    40 pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day    29 adult male 05day    38 adult male 30day    34 adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40 embryo 02-04hr    12 embryo 04-06hr    13 embryo 06-08hr    22 embryo 08-10hr    28 embryo 10-12hr    24 embryo 12-14hr    24 embryo 14-16hr    27 embryo 16-18hr    30 embryo 18-20hr    22 embryo 20-22hr    18 embryo 22-24hr    19 larva L1    11 larva L2    9 larva L3 12hr old    6 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    20 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    45 pupae 2d postWPP    40 pupae 3d postWPP    19 pupae 4d postWPP    21 adult male 01day    29 adult male 05day    38 adult male 30day    34 adult female 01day    19 adult female 05day    25 adult female 30day    25 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    6 embryonic 1182-4H    11 embryonic GM2    11 embryonic Kc167    6 embryonic S1    6 embryonic S3    6 leg disc CME L1    6 wing disc CME-W2    4 wing disc ML-DmD8    17 wing disc ML-DmD9    6 wing disc ML-DmD16-c3    21 wing disc ML-DmD21    4 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    5 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    8 tumorous blood cells mbn2    12 ovary fGS/OSS    5 ovary OSC    12 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (28) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  (32) Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult  (27) Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3  32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult  27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    28 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    20 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    32 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    27 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • GH25051 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004876 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6027-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(3R)bxd110) cdiB64 cdiG15 cdiH15 cdiL77 cdiM44 cdiN17 cdiT13 cdiU2 lethal | embryonic stage | fully | rescuable maternal effect cdi07013 lethal | larval stage (with Df(3R)bxd110) cdiA1 cdiC35 cdiR47 cdiS59 lethal | larval stage | recessive cdi07013 cdiR47 lethal | recessive cdi07013 cdiS418 viable cdi87 cdi242 cdiBA01 cdiCB05129 cdiEY11492 cdiGTD74-95.1 cdiKG10155 viable, with Scer\GAL4pnr-MD237 cdiGD8731 Sterility Allele fertile cdiEY11492 cdiKG10155 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 cdiGD8731 Phenotype manifest in Allele actin filament | somatic clone, with Scer\GAL4GMR.PU, mRpL55Scer\UAS.cSa cdiR47 anterior fascicle & synapse, with Scer\GAL4elav-C155 cdiEP3319 embryonic/first instar larval cuticle cdi07013 embryonic head cdi07013 embryonic segment cdi07013 filamentous actin | somatic clone, with Scer\GAL4Act5C.PU cdiScer\UAS.cSa head cdi07013 intersegmental nerve, with Scer\GAL4elav-C155 cdiEP3319 macrochaeta cdiBG02121 mesothoracic tergum, with Scer\GAL4pnr-MD237 cdiGD8731 nervous system cdiR47 photoreceptor cell R7, with Scer\GAL4hs.2sev cdiScer\UAS.cSa segment cdi07013
Classical Alleles ( 52 )
For All Classical Alleles Show
Allele of cdi Class Mutagen Stocks Known lesion cdiR47 amorphic allele - molecular evidence Delta2-3 1 Yes cdi07013 P-element activity 1 -- cdi5-HA-1833 1 -- cdic03096 piggyBac transposase 1 -- cdic06213a 1 -- cdic06916b 1 -- cdiCB-5796-3 1 -- cdid09519 P-element activity 1 -- cdie03411 piggyBac transposase 1 -- cdie03759 piggyBac transposase 1 -- cdif01120 piggyBac transposase 1 -- cdif01955 piggyBac transposase 1 -- cdif03390 piggyBac transposase 1 -- cdif05857 piggyBac transposase 1 -- cdif07656 piggyBac transposase 1 -- cdiKG10155 P-element activity 1 -- cdiMB02390 1 -- cdiMI01803 1 -- cdi242 P-element activity 0 Yes cdi33-077 P-element activity 0 Yes cdi33-077y- cre recombinase 0 Yes cdi34-165 P-element activity 0 Yes cdi34-165y- cre recombinase 0 Yes cdi44-004 P-element activity 0 Yes cdi44-004y- cre recombinase 0 Yes cdi87 P-element activity 0 Yes cdiA1 Delta2-3 0 Yes cdiB64 Delta2-3 0 Yes cdiBA01 P-element activity 0 Yes cdiBG02121 P-element activity 0 Yes cdiC35 Delta2-3 0 Yes cdiCB-5880-3 0 -- cdiCB05129 P-element activity 0 Yes cdid09797 P-element activity 0 -- cdid11274 P-element activity 0 -- cdid11657 P-element activity 0 -- cdiDG23401 P-element activity 0 -- cdiEP3319 P-element activity 0 Yes cdiEY11492 P-element activity 0 -- cdif06182 piggyBac transposase 0 -- cdiG15 Delta2-3 0 Yes cdiGTD74-95.1 P-element activity 0 Yes cdiH15 Delta2-3 0 Yes cdiL77 Delta2-3 0 Yes cdiM44 Delta2-3 0 Yes cdiN17 Delta2-3 0 Yes cdiQ29 0 -- cdiS418 P-element activity 0 Yes cdiS59 Delta2-3 0 Yes cdiT13 Delta2-3 0 Yes cdiU2 Delta2-3 0 Yes cdiunspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cdi Class Mutagen Stocks Known lesion cdiGD8731 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes cdiHMJ02227 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdiJF03006 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdiKK100725 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cdiNIG.6027R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cdiScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC473 (Christensen et al., 2008.4.15) Df(3R)BSC474 (Christensen et al., 2008.4.15) Df(3R)BSC742 (Christensen et al., 2009.2.28) Df(3R)Dl-BX12 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)ED5911 (Ryder and Roote, 2004.11.10) Df(3R)Exel6183 (Ryder, 2004.4.26)
Not disrupted in	Df(3R)Cha7 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Partially disrupted in	Df(3R)cdiR47 (Sese et al., 2006) Df(3R)mRpL55tmb13 (Tselykh et al., 2005) Df(3R)mRpL55tmb50 (Tselykh et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8731} NA P{KK100725} NA P{NIG.6027R} NA P{TRiP.HMJ02227} NA P{TRiP.JF03006} NA P{UAS-cdi.S} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{A92}cdiBA01 No P{FZ}cdi242 No P{lacW}l(3)SH144SH144 No P{lacZ}cdi87 No P{PZ}cdi07013 No P{PZ}cdiQ29 No miscellaneous insertions Mi{MIC}cdiMI01803 NA P{EP.Scer\UAS.(-loxP).BN}cdi33-077y- NA P{EP.Scer\UAS.(-loxP).BN}cdi34-165y- NA P{EP.Scer\UAS.(-loxP).BN}cdi44-004y- NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}cdi33-077 NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}cdi34-165 NA P{EP.Scer\UAS(loxP.Scer\UAS.y+).BN}cdi44-004 NA P{GT1}cdiBG02121 NA P{GTD-b}cdiGTD74-95.1 NA P{PTT-GB}cdiCB05129 NA P{RS3}cdiCB-5796-3 NA P{RS3}cdiCB-5880-3 NA P{RS5}cdi5-HA-1833 NA P{SUPor-P}cdiKG10155 NA P{wHy}cdiDG23401 NA PBac{PB}cdic03096 NA PBac{PB}cdic06213a NA PBac{PB}cdic06916b NA PBac{RB}cdie03411 NA PBac{RB}cdie03759 NA PBac{WH}cdif01120 NA PBac{WH}cdif01955 NA PBac{WH}cdif03390 NA PBac{WH}cdif05857 NA PBac{WH}cdif06182 NA PBac{WH}cdif07656 NA insertion of mobile activating element P{EP}cdiEP3319 NA P{EPgy2}cdiEY11492 NA P{XP}cdid09519 NA P{XP}cdid09797 NA P{XP}cdid11274 NA P{XP}cdid11657 NA insertion of enhancer trap binary system Mi{ET1}cdiMB02390 No P{GalW}cdiS418 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
actin filament organization inferred from mutant phenotype (Sese et al., 2006) embryonic development via the syncytial blastoderm inferred from mutant phenotype (Perrimon et al., 1996) negative regulation of sevenless signaling pathway inferred from genetic interaction with boss (Sese et al., 2006) inferred from genetic interaction with sev (Sese et al., 2006)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Sese et al., 2006) cytoplasm inferred from direct assay (Sese et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity (Matthews and Crews, 1999) inferred from sequence or structural similarity with UniProtKB:Q63572 (FlyBase, 1992-) non-traceable author statement (Fattah et al., 1996) protein tyrosine kinase activity inferred from electronic annotation with InterPro:IPR008266 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Matthews and Crews, 1999) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cdi allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67287 DroID - A comprehensive database of gene and protein interactions. • FBgn0004876 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42289
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6XWGH5 Dipteran inclusive ortholog search EOG6G1MQK Insect inclusive ortholog search EOG6WPZXQ Arthropod inclusive ortholog search EOG6TB2SD Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6XWGH5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cdi     Drosophila simulans   Dsim\GD20136 Y   Drosophila sechellia   Dsec\GM23341 Y   Drosophila erecta   Dere\GG16197 Y   Drosophila yakuba   Dyak\GE25154 Y   Drosophila ananassae   Dana\GF16418 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19308 Y   Drosophila persimilis   Dper\GL23714 Y   Drosophila willistoni   Dwil\GK13716 Y   Drosophila virilis   Dvir\GJ14359 Y   Drosophila mojavensis   Dmoj\GI22005 Y   Drosophila grimshawi   Dgri\GH22404 Y
Orthologs in non-Drosophila Dipterans (EOG6G1MQK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008413   Anopheles gambiae Malaria mosquito  Agam\AGAP004112   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016869
Orthologs in non-Dipteran Insects (EOG6WPZXQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54395   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019875   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22129   Atta cephalotes Leafcutter ant  Acep\ACEP21109   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23154   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15000   Linepithema humile Argentine ant  Lhum\LH17382   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14431   Solenopsis invicta Red fire ant  Sinv\SINV13974   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007809   Bombyx mori Silkmoth  Bmor\BGIBMGA010927   Pediculus humanus Human body louse  Phum\PHUM134620   Tribolium castaneum Red flour beetle  Tcas\TC012191
Orthologs in non-Insect Arthropods (EOG6TB2SD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Gnl3   Ixodes scapularis Deer tick  Isca\ISCW012529
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20136 Drosophila sechellia Dsec\GM23341 Drosophila erecta Dere\GG16197 Drosophila yakuba Dyak\GE25154 Drosophila ananassae Dana\GF16418 Drosophila pseudoobscura pseudoobscura Dpse\GA19308 Drosophila persimilis Dper\GL23714 Drosophila willistoni Dwil\GK13716 Drosophila virilis Dvir\GJ14359 Drosophila mojavensis Dmoj\GI22005 Drosophila grimshawi Dgri\GH22404
Stocks & Reagents
Stocks Listed in FlyBase ( 22 )
Bloomington	24441 w1118; Mi{ET1}cdiMB02390
Harvard	- P{XP}cdid09519 - PBac{PB}cdic03096 - PBac{RB}cdie03411 - PBac{RB}cdie03759 - PBac{WH}cdif01120 - PBac{WH}cdif01955 - PBac{WH}cdif03390 - PBac{WH}cdif05857 - PBac{WH}cdif07656
VDRC	v43634 w1118; P{GD8731}v43634 v43633 w1118; P{GD8731}v43633/CyO
	More stocks available...
Genomic Clones ( 3 )
	BACR07D13 BACR44N12 BACR48G05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 79 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25051 GM10731
Other clones	MIP15610 MIP21106
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01733 AT04329 AT12802 AT13325 AT29334 AT31661 GH06890 GH06990 GH09174 LP13732 RH21380
Other clones	11593 21224 51612 54795 54970 81367 117362 144293 144593 160249 167136 179695 214249.55 214473.66 214501.53 214535.71 281284 282071 282141 527207 AT12948 AT14130 CK01.18A.H11 CK01.69B.H12 CK01.116D.A2 CK01.141D.G6 Dmel_dig_005228_0608_1833 Dmel_neb_005538_0890_3480 Dmel_neb_010002_0666_3502 EC40757 EC051488 EC052525 EC053479 EC053940 EC055487 EC055911 EC055920 EK065448 EK112621 EK118059 EK135135 EK159111 EK174563 EK180762 EK180803 EK181716 EK215162 EK236722 EK250162 EK250258 EK273405 EK291428 EK306322 EK307515 EN07451 EP03108 EP04464 EP04557 EP19712 FGC024D09 FGH119C12 FGM211B04 FGM304D08 GM01567
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004876 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42289
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cdi l(3)07013 (FlyBase, 1996-)
Additional comments	Source for merge of cdi l(3)07013 was a shared cDNA (date:030206). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identified as a target gene regulated by the bithorax complex. (Fattah et al., 1996) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996) cdi encodes a novel protein kinase. (Matthews and Crews, 1992) sim gene product is required for the normal expression of cdi. (Nambu et al., 1990, Nambu et al., 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079677 NM_001260262 RefSeq (Proteins) • NP_524401 NP_001247191 DDBJ / EMBL / GenBank • AA694801 AA803362 AAD43525 AAF55630 AAL28524 AAO42656 AC006091 AF139811 AF139812 AFH06509 AI405131 AQ073910 AW940963 AW941354 AY060976 BG633542 BT004492 CL528284 CL844463 CZ468420 CZ476785 CZ476786 CZ476947 CZ476948 CZ477656 CZ477847 CZ481189 CZ481511 CZ481512 CZ483603 CZ483604 CZ484457 CZ485948 CZ485949 CZ488481 CZ488833 CZ490392 G00601 Entrez Gene - A searchable database of RefSeq genes. • 42289 UniProtKB/TrEMBL • Q9VE06 Q9Y1A8 Q95S32
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH25051
Linkouts
	BioGRID - A database of protein and genetic interactions • 67287 DroID - A comprehensive database of gene and protein interactions. • FBgn0004876 DRSC - Results from RNAi screens. • FBgn0004876 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004876 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6027-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004876 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42289 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42289 modMine - Data generated by the modENCODE project. • FBgn0004876
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	91F (Crews et al., 1992, Nambu et al., 1991, Nambu et al., 1990) B9.3 (Fattah, 1996.4.29, Fattah et al., 1996) Cdi (Fauvarque et al., 2002) cdi (Jiang and Crews, 2006, Hadar et al., 2012, Buszczak et al., 2007, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Chen et al., 2005, Christensen et al., 2009.2.28, Sese et al., 2006, Le Bras and Van Doren, 2006, Wasbrough et al., 2010, Tselykh et al., 2005, Takahashi et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Manning et al., 2012) cdi/TESK1 (Sese et al., 2005) Cdi/TESK1 (Raymond et al., 2004) CDI/TSKI (Morrison et al., 2000) CG6027 (Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000, Hadar et al., 2012, Perkins et al., 2009, Keleman et al., 2009.8.5, Tselykh et al., 2005, Ni et al., 2010.12.1) l(3)07013 (Spradling et al., 1999, Russell et al., 1998, Perrimon et al., 1996, BDGP Project Members, 1994-1999, ) unnamed (Lukacsovich et al., 2001)
Name Synonym	91F gene (Nambu et al., 1991, Nambu et al., 1990) center divider (Matthews, 1994.12.9, Jiang and Crews, 2006, Chen et al., 2005, Le Bras and Van Doren, 2006, Jordan et al., 2007) Center divider (Sese et al., 2006) central divider   Centre divider (Raymond et al., 2004)
Secondary FlyBase IDs
	FBgn0010912
References ( 74 )
Generate a list of	All references relating to this gene ( 74 )
List References by type	Research paper  ( 26 ) Supplementary material  ( 9 ) Review  ( 2 ) Personal communication to FlyBase  ( 21 ) Abstract  ( 9 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Siudeja et al., 2012, PLoS ONE 7(8): e43145 Cofilin/Twinstar phosphorylation levels increase in response to impaired coenzyme a metabolism. [FBrf0219241] Takahashi et al., 2012, Evolution 66(9): 2878--2890 Deficiency screening for genomic regions with effects on environmental sensitivity of the sensory bristles of Drosophila melanogaster. [FBrf0219405] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...