FB2019_06, released Dec 19, 2019

Gene: Dmel\cdi

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General Information
Symbol
Dmel\cdi
Species
D. melanogaster
Name
center divider
Annotation Symbol
CG6027
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004876
Gene Model Status
Current
Stock Availability
21 publicly available
Gene Snapshot
center divider (cdi) encodes a serine/threonine kinase that stimulates the formation of actin fibers and focal adhesions through phosphorylation of the F-actin depolimerization factor tsr. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As
l(3)07013, 91F, B9.3, 91F gene
Key Links
Genomic Location
Cytogenetic map
91E4-91F1
Sequence location
3R:19,044,882..19,094,270 [-]
Recombination map
3-65
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
ATP binding; protein serine/threonine kinase activity
Summaries
Pathway (FlyBase)
Negative Regulators of Sevenless Signaling Pathway -
Negative regulators of Sevenless signaling down-regulate the pathway, directing the presumptive R7 cell fate to that of a cone cell. (Adapted from FBrf0127283 and FBrf0221727).
Gene Group (FlyBase)
NON-RECEPTOR TLK KINASES -
Non-receptor tyrosine kinase-like (TKL) kinases are a diverse group of intracellular serine-threonine protein kinases with sequence similarity to tyrosine kinases (TK) but lacking TK-specific motifs.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\cdi or the JBrowse view of Dmel\cdi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.54
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cdi-RA
FBtr0083716
NM_079677
5665
1213
cdi-RB
FBtr0305321
NM_001260262
6523
942
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
cdi-PA
FBpp0083130
130.0
1213
6.79
NP_524401
AAF55630
cdi-PB
FBpp0293864
100.6
942
6.50
NP_001247191
AFH06509
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cdi using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (10 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein serine/threonine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001510238
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
actin filament organization
inferred from mutant phenotype
(Sese et al., 2006)
negative regulation of sevenless signaling pathway
inferred from genetic interaction with FLYBASE:boss; FB:FBgn0000206
(Sese et al., 2006)
inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366
(Sese et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
actin cytoskeleton organization
inferred from biological aspect of ancestor with PANTHER:PTN001510238
(assigned by GO_Central )
(Gaudet et al., 2011)
protein phosphorylation
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
apical part of cell
inferred from direct assay
(Sese et al., 2006)
cytosol
inferred from direct assay
(Sese et al., 2006)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN001510238
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001510238
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 13
ventral midline neuroblast
(Matthews and Crews, 1999)
ventral midline neuron
(Matthews and Crews, 1999)
midline glial cell
(Matthews and Crews, 1999)
embryonic stage 11 -- 13
embryonic foregut
(Matthews and Crews, 1999)
hindgut proper primordium
(Matthews and Crews, 1999)
embryonic proventriculus
(Matthews and Crews, 1999)
embryonic stage 9 -- 12
midline primordium
(Kearney et al., 2004)
embryonic stage 13 -- 16
midline glial cell
(Kearney et al., 2004)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Matthews and Crews, 1999)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Raymond et al., 2004)
Additional Descriptive Data
Expression pattern inferred from unspecified enhancer trap line.
(Kearney et al., 2004)
cdi transcripts are detected at all stages of embryogenesis as well as in larvae, pupae, and adults on northern blots. Only the shortest isoform is observed in early embryos and may be maternally transmitted. In situ hybridization shows nervous system expression specifically in the midline in both neurons and glia. Expression is also observed in the foregut, hindgut, and proventriculus.
(Matthews and Crews, 1999)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
Reporter: P{A92}cdiBA01
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 17
ventral midline neuroblast
(Matthews and Crews, 1999)
ventral midline neuron
(Matthews and Crews, 1999)
midline glial cell
(Matthews and Crews, 1999)
ventral midline
(Nambu et al., 1990)
embryonic stage 10
embryonic/larval anterior midgut
(Matthews and Crews, 1999)
embryonic/larval posterior midgut
(Matthews and Crews, 1999)
embryonic stage 13
embryonic/larval hindgut
(Matthews and Crews, 1999)
embryonic stage 13 -- 15
visceral mesoderm
(Matthews and Crews, 1999)
embryonic/larval proventriculus
(Matthews and Crews, 1999)
embryonic/larval epidermis
(Matthews and Crews, 1999)
Reporter: P{FZ}cdi242
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 13
ventral midline neuroblast
(Matthews and Crews, 1999)
embryonic stage 13 -- 17
ventral midline neuron
(Matthews and Crews, 1999)
embryonic stage 9 -- 17
midline glial cell
(Matthews and Crews, 1999)
ventral midline
(Nambu et al., 1990)
adult stage | male
germinal proliferation center
(Raymond et al., 2004)
spermatocyte
(Raymond et al., 2004)
Reporter: P{lacZ}cdi87
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 17
ventral midline
(Nambu et al., 1990)
ventral midline neuroblast
(Matthews and Crews, 1999)
ventral midline neuron
(Matthews and Crews, 1999)
midline glial cell
(Matthews and Crews, 1999)
embryonic stage 10
embryonic/larval anterior midgut
(Matthews and Crews, 1999)
embryonic/larval posterior midgut
(Matthews and Crews, 1999)
embryonic stage 13
embryonic/larval hindgut
(Matthews and Crews, 1999)
embryonic stage 13 -- 15
visceral mesoderm
(Matthews and Crews, 1999)
embryonic/larval proventriculus
(Matthews and Crews, 1999)
embryonic/larval epidermis
(Matthews and Crews, 1999)
Reporter: P{PZ}cdiQ29
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 17
gonadal sheath proper primordium
(Le Bras and Van Doren, 2006)
adult stage
hub cell
(Le Bras and Van Doren, 2006)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cdi in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 55 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cdi
Transgenic constructs containing regulatory region of cdi
Deletions and Duplications ( 10 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(3R)bxd110)
lethal | embryonic stage | rescuable maternal effect
lethal | larval stage | recessive
lethal | recessive
lethal - all die before end of larval stage (with Df(3R)bxd110)
lethal - all die before end of larval stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
some die during larval stage (with Df(3R)bxd110)
some die during larval stage | recessive
Phenotype manifest in
Allele
actin filament | somatic clone, with Scer\GAL4GMR.PU, mRpL55UAS.cSa
anterior fascicle & synapse, with Scer\GAL4elav-C155
embryonic/first instar larval cuticle
embryonic head
embryonic segment
filamentous actin | somatic clone, with Scer\GAL4Act5C.PU
head
intersegmental nerve, with Scer\GAL4elav-C155
macrochaeta
mesothoracic tergum, with Scer\GAL4pnr-MD237
nervous system
photoreceptor cell R7, with Scer\GAL4hs.2sev
segment
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TESK2
10 of 15
Yes
Yes
Hsap\TESK1
8 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Tesk2
10 of 15
Yes
Yes
Mmus\Tesk1
7 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
Rnor\Tesk2
8 of 13
Yes
Yes
Rnor\Tesk1
5 of 13
No
Yes
Rnor\Aatk
1 of 13
No
Yes
Rnor\Lmtk2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\tesk2
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (5)
Drer\tesk2
9 of 15
Yes
Yes
Drer\si:dkeyp-75h12.2
8 of 15
No
Yes
Drer\si:ch211-113e8.3
7 of 15
No
Yes
Drer\zgc:113162
3 of 15
No
Yes
Drer\zgc:162952
3 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\Y69E1A.3
2 of 15
Yes
No
Cele\K09B11.5
1 of 15
No
No
Cele\kin-21
1 of 15
No
No
Cele\T25B9.5
1 of 15
No
No
Cele\Y52D5A.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\PTK1
1 of 15
Yes
No
Scer\PTK2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901AZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\cdi
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00012169
Drosophila simulans
Dsim\GD20136
Drosophila sechellia
Dsec\GM23341
Drosophila erecta
Dere\GG16197
Drosophila yakuba
Dyak\GE25154
Drosophila ananassae
Dana\GF16418
Drosophila pseudoobscura pseudoobscura
Dpse\GA19308
Drosophila persimilis
Dper\GL23714
Drosophila willistoni
Dwil\GK13716
Drosophila virilis
Dvir\GJ14359
Drosophila mojavensis
Dmoj\GI22005
Drosophila grimshawi
Dgri\GH22404
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502WT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019728
Glossina morsitans
Tsetse fly
Gmor\GMOY009489
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14016
Mayetiola destructor
Hessian fly
Mdes\Mdes004244
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008413
Anopheles darlingi
American malaria mosquito
Adar\ADAC009843
Anopheles gambiae
Malaria mosquito
Agam\AGAP004112
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016869
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0B0T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010928
Bombyx mori
Silkmoth
Bmor\BGIBMGA010927
Danaus plexippus
Monarch butterfly
Dple\DPOGS209924-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016744
Apis florea
Little honeybee
Aflo\2467440196
Apis mellifera
Western honey bee
Amel\GB54395
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20580
Bombus terrestris
Buff-tailed bumblebee
Bter\15206244
Linepithema humile
Argentine ant
Lhum\LH17382
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00066a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019875
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12846
Tribolium castaneum
Red flour beetle
Tcas\TC012191
Pediculus humanus
Human body louse
Phum\PHUM134620
Rhodnius prolixus
Kissing bug
Rpro\RPRC000404
Cimex lectularius
Bed bug
Clec\CLEC025069
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007809
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14592
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0AXY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013115
Ixodes scapularis
Black-legged tick
Isca\ISCW012529
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78248.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_30877
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
LIMK1
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    cdiEP3319
    exacerbates  tauopathy
    modeled by Hsap\MAPTV337M.UAS
    (Shulman and Feany, 2003)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TESK2; testis associated actin remodelling kinase 2
    10 of 15
    604746
        TESK1; testis associated actin remodelling kinase 1
        8 of 15
        601782
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            boss
            suppressible
            cdi
            (Sese et al., 2006)
            Pax
            suppressible
            cdi
            (Chen et al., 2005)
            Rac1
            suppressible
            cdi
            (Raymond et al., 2004)
            Rac1
            enhanceable
            cdi
            (Raymond et al., 2004)
            RacGAP84C
            suppressible
            cdi
            (Raymond et al., 2004)
            sev
            suppressible
            cdi
            (Sese et al., 2006)
            External Data
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Negative Regulators of Sevenless Signaling Pathway -
            Negative regulators of Sevenless signaling down-regulate the pathway, directing the presumptive R7 cell fate to that of a cone cell. (Adapted from FBrf0127283 and FBrf0221727).
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map
            3-65
            Cytogenetic map
            91E4-91F1
            Sequence location
            3R:19,044,882..19,094,270 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            91E4-91F1
            Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            91F1-91F3
            (determined by in situ hybridisation)
            (Lukacsovich et al., 2001)
            91F-91F
            (Matthews, 1999.3.31)
            91F1-91F5
            (determined by in situ hybridisation)
            (Spradling et al., 1999, Perrimon et al., 1996)
            91F-91F
            (determined by in situ hybridisation)
            (Matthews and Crews, 1999, Matthews and Crews, 1992)
            91F1-91F5
            (BDGP Project Members, 1994-1999)
            Experimentally Determined Recombination Data
            Location
            3-65
            (FlyBase, 2016)
            3-65.2
            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (21)
            Genomic Clones (33)
            cDNA Clones (77)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of
            Source for database merge of
            Source for merge of: cdi l(3)07013
            (FlyBase, 1996-)
            Additional comments
            Source for merge of cdi l(3)07013 was a shared cDNA ( date:030206 ).
            (FlyBase, 1996-)
            Other Comments
            dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
            (Kiger et al., 2003)
            Identified as a target gene regulated by the bithorax complex.
            (Fattah et al., 1996)
            The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.
            (Perrimon et al., 1996)
            cdi encodes a novel protein kinase.
            (Matthews and Crews, 1992)
            sim gene product is required for the normal expression of cdi.
            (Nambu et al., 1991, Nambu et al., 1990)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 70 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (genetic) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (15)
            Reported As
            Symbol Synonym
            91F
            (Crews et al., 1992, Nambu et al., 1991, Nambu et al., 1990)
            B9.3
            (Fattah, 1996.4.29, Fattah et al., 1996)
            CDI/TSKI
            (Morrison et al., 2000)
            CG6027
            (Hosono et al., 2015, Sun et al., 2014, Hadar et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Tselykh et al., 2005, Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Morrison et al., 2000)
            Cdi
            (Fauvarque et al., 2002)
            Cdi/TESK1
            (Raymond et al., 2004)
            cdi
            (Clandinin and Owens, 2016-, Hunter et al., 2016, Duff et al., 2015, Gene Disruption Project members, 2015-, Kanoh et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Chandran et al., 2014, Merlo et al., 2014, Sopko et al., 2014, Sen et al., 2013, Hadar et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Manning et al., 2012, Takahashi et al., 2012, Wasbrough et al., 2010, Christensen et al., 2009.2.28, Christensen et al., 2008.4.15, Christensen et al., 2008.4.15, Buszczak et al., 2007, Jiang and Crews, 2006, Le Bras and Van Doren, 2006, Sese et al., 2006, Chen et al., 2005, Tselykh et al., 2005)
            cdi/TESK1
            (Sese et al., 2005)
            l(3)07013
            (Spradling et al., 1999, Russell et al., 1998, Perrimon et al., 1996, BDGP Project Members, 1994-1999)
            Name Synonyms
            91F gene
            (Nambu et al., 1991, Nambu et al., 1990)
            Center divider
            (Sese et al., 2006)
            Centre divider
            (Raymond et al., 2004)
            center divider
            (Jordan et al., 2007, Jiang and Crews, 2006, Le Bras and Van Doren, 2006, Chen et al., 2005, Matthews, 1994.12.9)
            central divider
            centrer divider
            (Chandran et al., 2014)
            Secondary FlyBase IDs
            • FBgn0010912
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (101)