Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scrt using the Feature Mapper tool.
Comment: reported as dorsal/lateral sensory complexes
scrt is first expressed in the embryo in S1 neuroblasts. It is expressed in most cells of the CNS by stage 12, with the strongest expression in a group of 5-7 cells per abdominal hemisegment arranged in a crescent.
The scrt transcript is expressed in neuronal precursor cells. In northern blots, the 6.5 kb scrt transcript is detected in 4-12 hour embryos, but not in 0-4 hour embryos. By in situ hybridization, scrt transcript is detected at stage 8 in a single row of ectodermal cells flanking the ventral midline. These cells then delaminate and contribute to the first three rows of stage 1 neuroblasts in the central nervous system. Subsequently, all stage 1 neuroblasts and then later neuroblasts, express scrt. The ganglion mother cells and postmitotic neurons also express scrt. In the peripheral nervous system, scrt is expressed first in the sensory mother cells, then in secondary precursor cells, and finally in postmitotic neurons. In third instar larvae, scrt is expressed in neuronal cells of the wing disc, in cells posterior to the morphogenetic furrow of eye-antennal discs, in neuronal precursor cells in the leg disc, and in many cells in the brain and the ventral nerve cord. scrt transcript is also detected in developing neurons of the pupal wing.
GBrowse - Visual display of RNA-Seq signalsView Dmel\scrt in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: scrt CG1130
dsRNA has been made from templates generated with primers directed against this gene. RNAi of scrt results in reduced arborization of ddaD and ddaE neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Area matching Drosophila EST AI107456.
Candidate gene for quantitative trait (QTL) locus determining bristle number.
Gene named after the scratched mutant phenotype in the eye and the five zinc fingers of the encoded product.