Mutations in bwk affect the proper formation of the eggshell and embryo. grk^-;bwk^- double mutant phenotype suggests wild type bwk product is needed to define the shape of the dorsal eggshell filaments after their placement has been determined by the dorsoventral pathway. The bicaudal phenotype of mutant embryos suggests bwk is important for determining or maintaining anterior/posterior polarity during oogenesis.

Strong alleles have wing defects: blistered wings with extra veins.

bwk is necessary for proper formation of the eggshell.

In strong alleles, wings blistered with extra vein material.

"hab" is allelic to "cic" and "bwk". This locus is genetically and molecularly complex, encoding distinct genetic functions and producing multiple isoforms.

Molecular analysis indicates that the "fet" and "cic" mutations are allelic (mutant lesions responsible for "fet" mutations are located in the open reading frame of the "cic" gene, and a "cic" rescue construct rescues the maternal and zygotic "fet" phenotypes). cic¹/cic^fet-U6 females produce embryos with a tor gain-of-function phenotype, indicating that both alleles affect the same germline function. However, cic¹ complements the follicle cell defect of "fet" mutants, as eggs laid by transheterozygous females show apparently normal dorsoventral polarity of the eggshell and embryo. The relationship between "cic" (and therefore "fet") and "bwk" is unclear. "bwk" alleles complement the "fet" eggshell and wing defects, while the embryos laid by "fet"/"bwk" transheterozygotes are bicaudal (maternal effect "bwk" mutations result in bicaudal embryos).

The P{PZ} insertion in "bwk⁰⁸⁴⁸²" maps approximately 300bp away from the hobo insertion in "cic¹". However, "cic¹" and "bwk⁰⁸⁴⁸²" complement each other, produce different phenotypes and while the P{cic^+tJa} construct rescues "cic¹", it does not rescue "bwk⁰⁸⁴⁸²", indicating that "bwk" and cic represent separate gene functions.