Gene model reviewed during 5.41
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FoxL1 using the Feature Mapper tool.
FoxL1 transcripts are expressed in the embryo from stage 9 in the hindgut. They are also expressed in a segmentally repeated pattern in the mesoderm that becomes largely restricted to T2 and T3 late in embryogenesis. They are also detected in the region of the visceral mesoderm where the gastric caeca form.
fd64A transcripts are first observed in cells which comprise a ventral spot in a posterior position of the cellular blastoderm. These cells invaginate and demarcate the posterior portion of the mesoderm. In the extended germ band, expression is observed in 10 segmental pairs of cell clusters that are thought to be mesodermal. The transcripts are at low abundance.
FoxL1 protein is detected in embryos in a muscle that was identified as prothoracic ventral intersegmental muscle 5 (VIS5). It is also detected in mesodermal cells surrounding the small intestine, in the region of the visceral mesoderm where the gastric caeca form, and in cells dorsal to the salivary gland likely to be alary muscle TARM T1.
GBrowse - Visual display of RNA-Seq signalsView Dmel\FoxL1 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.
The 110 amino acid domain is split by an intron in fd64A.
One of seven genes identified on basis of sequence similarity to the 110 amino acid forkhead domain that is conserved in the rodent hepatocyte enriched nuclear transcription factor.
Named as 'FoxL1' after the most related mammalian protein.