FB2020_02, released Apr 14, 2020

Gene: Dmel\fd59A

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General Information
Symbol
Dmel\fd59A
Species
D. melanogaster
Name
forkhead domain 59A
Annotation Symbol
CG3668
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004896
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Snapshot
forkhead domain 59A (fd59A) encodes a transcription factor that is expressed largely in postmitotic neurons in the central nervous system. Its roles include nervous system development and egg-laying behavior. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

FD3

Key Links
Genomic Location
Cytogenetic map
59B4-59B4
Sequence location
2R:22,868,159..22,870,706 [+]
Recombination map

2-101

RefSeq locus
NT_033778 REGION:22868159..22870706
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Protein Function (UniProtKB)
Involved in development during embryogenesis.
(UniProt, Q02361)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\fd59A or the JBrowse view of Dmel\fd59A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
fd59A-RA
FBtr0071898
NM_079090
2228
456
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
fd59A-PA
FBpp0071809
49.1
456
5.19
NP_523814
AAF46917
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fd59A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (6 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
(Gaudet et al., 2011)
sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
anatomical structure morphogenesis
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
(Gaudet et al., 2011)
cell differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000930906
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ventral midline
(Hacker et al., 1992)
embryonic brain
(Hacker et al., 1992)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval thoracic sensillum | precursor
(Hacker et al., 1992)
neuroblast
(Hacker et al., 1992)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
mushroom body primordium

Comment: reported as embryonic central brain mushroom body

(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral midline neuron
(Kearney et al., 2004)
embryonic stage 11
ventral midline | subset

Comment: late stage 11

(Wheeler et al., 2006)
embryonic stage 13
VUM motor neuron
(Wheeler et al., 2006)
median neuroblast MNB interneuron
(Wheeler et al., 2006)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
Additional Descriptive Data

fd59A transcripts are first expressed in germ band extended embryos in small clusters of cells that are probably neuroblasts derived from the procephalic neurogenic region and in a subset of precursors to the ventral nervous system. Later, they accumulate in segmentally repeated rows of cells in the ventral nervous system, in a subset of midline cells, prominently in a pair of thoracic sensory organs, and in a subpattern of brain cells. The transcripts are at very low abundance.

(Hacker et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
neuroblast MNB
(Lacin and Truman, 2016)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\fd59A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of fd59A
Transgenic constructs containing regulatory region of fd59A
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (40)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FOXD3
9 of 15
Yes
Yes
 
Hsap\FOXD2
7 of 15
No
Yes
Hsap\FOXD4
6 of 15
No
Yes
Hsap\FOXD4L3
6 of 15
No
Yes
Hsap\FOXD4L4
6 of 15
No
Yes
Hsap\FOXD4L1
5 of 15
No
Yes
Hsap\FOXD4L5
5 of 15
No
Yes
Hsap\FOXD4L6
5 of 15
No
Yes
Hsap\FOXL1
4 of 15
No
No
Hsap\FOXC1
3 of 15
No
No
Hsap\FOXD1
3 of 15
No
Yes
Hsap\FOXE1
3 of 15
No
Yes
Hsap\FOXE3
3 of 15
No
Yes
Hsap\FOXJ1
3 of 15
No
Yes
Hsap\FOXB1
2 of 15
No
No
Hsap\FOXB2
2 of 15
No
No
Hsap\FOXC2
2 of 15
No
No
Hsap\FOXG1
2 of 15
No
No
Hsap\FOXI1
2 of 15
No
No
Hsap\FOXI2
2 of 15
No
No
Hsap\FOXI3
2 of 15
No
No
Hsap\FOXK1
2 of 15
No
No
Hsap\FOXK2
2 of 15
No
No
Hsap\FOXQ1
2 of 15
No
No
Hsap\FOXS1
2 of 15
No
No
Hsap\CHEK2
1 of 15
No
No
Hsap\FOXA1
1 of 15
No
No
Hsap\FOXA2
1 of 15
No
No
Hsap\FOXA3
1 of 15
No
No
Hsap\FOXF1
1 of 15
No
No
Hsap\FOXF2
1 of 15
No
No
Hsap\FOXH1
1 of 15
No
Yes
Hsap\FOXJ2
1 of 15
No
No
Hsap\FOXJ3
1 of 15
No
No
Hsap\FOXL2
1 of 15
No
No
Hsap\FOXM1
1 of 15
No
Yes
 
Hsap\IL2RG
1 of 15
No
Yes
Hsap\INSR
1 of 15
No
No
 
Hsap\SBK3
1 of 15
No
No
Hsap\WI2-2373I1.2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Foxd3
9 of 15
Yes
Yes
Mmus\Foxd2
7 of 15
No
Yes
Mmus\Foxd1
6 of 15
No
Yes
Mmus\Foxd4
4 of 15
No
Yes
Mmus\Foxl1
4 of 15
No
No
Mmus\Foxc1
3 of 15
No
No
Mmus\Foxc2
3 of 15
No
No
Mmus\Foxe1
3 of 15
No
Yes
Mmus\Foxe3
3 of 15
No
Yes
Mmus\Foxg1
3 of 15
No
No
Mmus\Foxj1
3 of 15
No
Yes
Mmus\Gm5294
3 of 15
No
Yes
Mmus\Foxb1
2 of 15
No
No
Mmus\Foxb2
2 of 15
No
No
Mmus\Foxi1
2 of 15
No
No
Mmus\Foxi2
2 of 15
No
No
Mmus\Foxi3
2 of 15
No
No
Mmus\Foxk1
2 of 15
No
No
Mmus\Foxk2
2 of 15
No
No
Mmus\Foxl2
2 of 15
No
No
Mmus\Foxq1
2 of 15
No
No
Mmus\Foxa1
1 of 15
No
No
Mmus\Foxa2
1 of 15
No
No
Mmus\Foxa3
1 of 15
No
No
Mmus\Foxf1
1 of 15
No
No
Mmus\Foxf2
1 of 15
No
No
Mmus\Foxh1
1 of 15
No
Yes
Mmus\Foxj2
1 of 15
No
No
Mmus\Foxj3
1 of 15
No
No
Mmus\Foxm1
1 of 15
No
No
Mmus\Foxs1
1 of 15
No
No
Rattus norvegicus (Norway rat) (31)
Rnor\Foxd2
6 of 13
Yes
Yes
Rnor\Foxd1
4 of 13
No
Yes
Rnor\Foxd3
4 of 13
No
Yes
Rnor\Foxc1
3 of 13
No
No
Rnor\Foxc2
3 of 13
No
No
Rnor\Foxd4
3 of 13
No
Yes
Rnor\Foxe1
3 of 13
No
Yes
Rnor\Foxe3
3 of 13
No
Yes
Rnor\Foxl1
3 of 13
No
No
Rnor\LOC680273
3 of 13
No
Yes
Rnor\Foxg1
2 of 13
No
No
Rnor\Foxi1
2 of 13
No
No
Rnor\Foxi2
2 of 13
No
No
Rnor\Foxi3
2 of 13
No
No
Rnor\Foxj1
2 of 13
No
Yes
Rnor\Foxl2
2 of 13
No
No
Rnor\Foxq1
2 of 13
No
No
Rnor\Foxs1
2 of 13
No
No
Rnor\Foxa1
1 of 13
No
No
Rnor\Foxa2
1 of 13
No
No
Rnor\Foxa3
1 of 13
No
No
Rnor\Foxb1
1 of 13
No
No
Rnor\Foxb2
1 of 13
No
No
Rnor\Foxf1
1 of 13
No
No
Rnor\Foxf2
1 of 13
No
Yes
Rnor\Foxh1
1 of 13
No
Yes
Rnor\Foxj2
1 of 13
No
No
Rnor\Foxj3
1 of 13
No
No
Rnor\Foxk1
1 of 13
No
No
Rnor\Foxk2
1 of 13
No
No
Rnor\Foxm1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (33)
Xtro\foxd4l1.1
8 of 12
Yes
Yes
Xtro\foxd4l1.2
7 of 12
No
Yes
Xtro\foxd2
6 of 12
No
Yes
Xtro\foxd3
6 of 12
No
Yes
Xtro\foxd1
5 of 12
No
Yes
Xtro\foxi4.2
3 of 12
No
No
Xtro\foxj1
3 of 12
No
Yes
Xtro\foxb1
2 of 12
No
No
Xtro\foxc1
2 of 12
No
No
Xtro\foxc2
2 of 12
No
No
Xtro\foxe1
2 of 12
No
No
Xtro\foxe3
2 of 12
No
No
Xtro\foxg1
2 of 12
No
Yes
Xtro\foxi1
2 of 12
No
No
Xtro\foxi2
2 of 12
No
No
Xtro\foxi4.1
2 of 12
No
No
Xtro\foxj1.2
2 of 12
No
Yes
Xtro\foxk2
2 of 12
No
No
Xtro\foxl1
2 of 12
No
No
Xtro\foxl2
2 of 12
No
No
Xtro\foxq1
2 of 12
No
No
Xtro\wi2-2373i1.2
2 of 12
No
Yes
Xtro\foxa1
1 of 12
No
No
Xtro\foxa2
1 of 12
No
No
Xtro\foxa4
1 of 12
No
No
Xtro\foxb2
1 of 12
No
No
Xtro\foxf1
1 of 12
No
No
Xtro\foxf2
1 of 12
No
No
Xtro\foxh1
1 of 12
No
No
Xtro\foxj2
1 of 12
No
No
Xtro\foxj3
1 of 12
No
Yes
Xtro\foxm1
1 of 12
No
Yes
Xtro\LOC101730723
1 of 12
No
Yes
Danio rerio (Zebrafish) (46)
Drer\foxd3
7 of 15
Yes
Yes
Drer\foxd1
6 of 15
No
Yes
Drer\foxd2
6 of 15
No
Yes
Drer\foxd5
6 of 15
No
Yes
Drer\zgc:162612
6 of 15
No
Yes
Drer\foxe1
4 of 15
No
Yes
Drer\foxe3
4 of 15
No
Yes
Drer\foxl1
4 of 15
No
No
Drer\foxc1a
3 of 15
No
No
Drer\foxc1b
3 of 15
No
No
Drer\foxg1a
3 of 15
No
No
Drer\foxj1a
3 of 15
No
Yes
Drer\foxq2
3 of 15
No
No
Drer\si:dkey-7e14.3
3 of 15
No
Yes
Drer\zgc:194189
3 of 15
No
Yes
Drer\foxb1a
2 of 15
No
No
Drer\foxb1b
2 of 15
No
No
Drer\foxb2
2 of 15
No
No
Drer\foxf2b
2 of 15
No
No
Drer\foxg1b
2 of 15
No
No
Drer\foxg1c
2 of 15
No
No
Drer\foxg1d
2 of 15
No
No
Drer\foxi1
2 of 15
No
No
Drer\foxi2
2 of 15
No
No
Drer\foxi3a
2 of 15
No
No
Drer\foxi3b
2 of 15
No
No
Drer\foxj1b
2 of 15
No
Yes
Drer\foxj2
2 of 15
No
No
Drer\foxk1
2 of 15
No
No
Drer\foxk2
2 of 15
No
No
Drer\foxl2a
2 of 15
No
No
Drer\foxl2b
2 of 15
No
No
Drer\foxq1a
2 of 15
No
No
Drer\foxq1b
2 of 15
No
No
Drer\si:ch211-145o7.3
2 of 15
No
Yes
Drer\si:ch211-262e15.1
2 of 15
No
No
Drer\foxa1
1 of 15
No
No
Drer\foxa2
1 of 15
No
No
Drer\foxa3
1 of 15
No
No
Drer\foxa
1 of 15
No
No
Drer\foxf1
1 of 15
No
No
Drer\foxf2a
1 of 15
No
No
Drer\foxh1
1 of 15
No
No
Drer\foxj3
1 of 15
No
No
Drer\foxm1
1 of 15
No
Yes
Drer\foxo6a
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\unc-130
10 of 15
Yes
Yes
Cele\fkh-2
3 of 15
No
No
Cele\fkh-10
3 of 15
No
No
Cele\lin-31
3 of 15
No
No
Cele\fkh-6
2 of 15
No
No
Cele\let-381
2 of 15
No
No
Cele\pes-1
2 of 15
No
No
Cele\pha-4
2 of 15
No
No
Cele\fkh-3
1 of 15
No
Yes
Cele\fkh-4
1 of 15
No
Yes
Cele\fkh-8
1 of 15
No
No
Cele\fkh-9
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\FKH1
5 of 15
Yes
Yes
Scer\FKH2
4 of 15
No
Yes
Scer\HCM1
4 of 15
No
No
Scer\FHL1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\mei4
4 of 12
Yes
No
Spom\sep1
4 of 12
Yes
No
Spom\fhl1
3 of 12
No
Yes
Spom\fkh2
3 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190BGX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002149
Drosophila simulans
Dsim\GD11717
Drosophila sechellia
Dsec\GM15965
Drosophila erecta
Dere\GG22808
Drosophila yakuba
Dyak\GE14241
Drosophila ananassae
Dana\GF13549
Drosophila pseudoobscura pseudoobscura
Dpse\GA17601
Drosophila persimilis
Dper\GL10130
Drosophila willistoni
Dwil\GK20787
Drosophila virilis
Dvir\GJ22399
Drosophila mojavensis
Dmoj\GI20546
Drosophila grimshawi
Dgri\GH21797
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508ES )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025230
Glossina morsitans
Tsetse fly
Gmor\GMOY010857
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08669
Mayetiola destructor
Hessian fly
Mdes\Mdes011090
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014284
Anopheles gambiae
Malaria mosquito
Agam\AGAP008155
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004866
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0924 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004141
Danaus plexippus
Monarch butterfly
Dple\DPOGS214339-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006482
Apis florea
Little honeybee
Aflo\2842763828
Apis mellifera
Western honey bee
Amel\GB42758
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP19823
Bombus terrestris
Buff-tailed bumblebee
Bter\15206505
Linepithema humile
Argentine ant
Lhum\LH23251
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ac2
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ac1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013184
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10287
Tribolium castaneum
Red flour beetle
Tcas\TC015957
Pediculus humanus
Human body louse
Phum\PHUM518310
Cimex lectularius
Bed bug
Clec\CLEC006815
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007895
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0B2Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000486
Ixodes scapularis
Black-legged tick
Isca\ISCW015937
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60408.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur22g00300
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_28765
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0HW9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FoxL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FoxC
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FoxA
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FoxD
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-FoxD_1
Ciona intestinalis
Vase tunicate
Cint\foxc
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023488
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003394
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022098
Ciona intestinalis
Vase tunicate
Cint\foxd-a/b
Ciona intestinalis
Vase tunicate
Cint\foxE
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000012644
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028153
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000025873
Gallus gallus
Domestic chicken
Ggal\FOXC2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000022935
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026252
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (17)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
fd102C
5 of 10
FoxL1
5 of 10
slp1
5 of 10
croc
4 of 10
fd19B
4 of 10
fd96Ca
4 of 10
fd96Cb
4 of 10
slp2
4 of 10
fkh
3 of 10
FoxK
3 of 10
bin
2 of 10
CG32006
2 of 10
fd3F
2 of 10
jumu
2 of 10
CHES-1-like
1 of 10
foxo
1 of 10
FoxP
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FOXD3; forkhead box D3
    9 of 15
    611539
       
      FOXD2; forkhead box D2
      7 of 15
      602211
          FOXD4; forkhead box D4
          6 of 15
          601092
              FOXD4L3; forkhead box D4 like 3
              6 of 15
              611086
                  FOXD4L4; forkhead box D4 like 4
                  6 of 15
                  611085
                      FOXD4L1; forkhead box D4 like 1
                      5 of 15
                      611084
                          FOXD4L5; forkhead box D4 like 5
                          5 of 15
                              FOXD4L6; forkhead box D4 like 6
                              5 of 15
                                  FOXL1; forkhead box L1
                                  4 of 15
                                  603252
                                      FOXC1; forkhead box C1
                                      3 of 15
                                      601090
                                      FOXD1; forkhead box D1
                                      3 of 15
                                      601091
                                          FOXE1; forkhead box E1
                                          3 of 15
                                          602617
                                          FOXE3; forkhead box E3
                                          3 of 15
                                          601094
                                          FOXJ1; forkhead box J1
                                          3 of 15
                                          602291
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            Summary of Genetic Interactions
                                            esyN Network Diagram
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            External Data
                                            Linkouts
                                            BioGRID - A database of protein and genetic interactions.
                                            DroID - A comprehensive database of gene and protein interactions.
                                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            External Data
                                            Linkouts
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            2R
                                            Recombination map

                                            2-101

                                            Cytogenetic map
                                            59B4-59B4
                                            Sequence location
                                            2R:22,868,159..22,870,706 [+]
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            59B4-59B4
                                            Limits computationally determined from genome sequence between P{PZ}blw03972 and P{EP}EP627
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            59A-59A
                                            (determined by in situ hybridisation)
                                            (Hacker et al., 1992)
                                            Experimentally Determined Recombination Data
                                            Location

                                            2-101

                                            (FlyBase, 2016)

                                            2-106.0

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            Right of (cM)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (11)
                                            Genomic Clones (20)
                                            cDNA Clones (3)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequences
                                            BDGP DGC clones
                                            Other clones
                                            Drosophila Genomics Resource Center cDNA clones

                                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                            cDNA Clones, End Sequenced (ESTs)
                                            BDGP DGC clones
                                              Other clones
                                                RNAi and Array Information
                                                Linkouts
                                                DRSC - Results frm RNAi screens
                                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                Antibody Information
                                                Laboratory Generated Antibodies
                                                 

                                                polyclonal

                                                (Lacin et al., 2014)
                                                Commercially Available Antibodies
                                                 
                                                Other Information
                                                Relationship to Other Genes
                                                Source for database identify of
                                                Source for database merge of
                                                Additional comments
                                                Other Comments

                                                Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

                                                (Clark et al., 1993)

                                                One of seven genes identified on basis of sequence similarity to the 110 amino acid forkhead domain that is conserved in the rodent hepatocyte enriched nuclear transcription factor.

                                                (Hacker et al., 1992)
                                                Origin and Etymology
                                                Discoverer
                                                Etymology
                                                Identification
                                                External Crossreferences and Linkouts ( 35 )
                                                Sequence Crossreferences
                                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                Other crossreferences
                                                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                Flygut - An atlas of the Drosophila adult midgut
                                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                InterPro - A database of protein families, domains and functional sites
                                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                                modMine - A data warehouse for the modENCODE project
                                                Linkouts
                                                BioGRID - A database of protein and genetic interactions.
                                                DPiM - Drosophila Protein interaction map
                                                DroID - A comprehensive database of gene and protein interactions.
                                                DRSC - Results frm RNAi screens
                                                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                FlyMine - An integrated database for Drosophila genomics
                                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                                Synonyms and Secondary IDs (10)
                                                Datasets (0)
                                                Study focus (0)
                                                Experimental Role
                                                Project
                                                Project Type
                                                Title
                                                References (54)