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Gene Dmel\Rb97D

General Information
Symbol	Dmel\Rb97D	Species	D. melanogaster
Name	Ribonuclear protein at 97D	Annotation symbol	CG6354
Feature type	protein_coding_gene	FlyBase ID	FBgn0004903
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97D3-97D3	Sequence location	3R:22,697,851..22,701,464 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribonuclear protein at 97D is referred to in FlyBase by the symbol Dmel\Rb97D (CG6354, FBgn0004903). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. There is experimental evidence that it is involved in the biological process: spermatid development. 11 alleles are reported. The phenotype of these alleles is annotated with: axoneme. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval fat body, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1641564_a_at completely aligns to an exonic region common to each of the 9 FlyBase-annotated transcript isoforms of Rb97D. Gene sequence location is 3R:22697851..22701464.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97D3-97D3   Limits computationally determined from genome sequence between P{lacW}His2AvL1602 and P{PZ}sda03884
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97D2-97D3   (determined by in situ hybridisation)   (Ranz et al., 2001) 97D-97D     (Karsch-Mizrachi, 1992) 97D1-97D15   (determined by in situ hybridisation)   (Spradling et al., 1999) 97D-97D   (determined by in situ hybridisation)   (Ranz et al., 1997) 97D1-97D15     (BDGP Project Members, 1994-1999) 97D-97D   (determined by in situ hybridisation)   (Karsch-Mizrachi and Haynes, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rb97D for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rb97D-RA FBtr0085092  NM_170293   2629   465 Rb97D-RB FBtr0085093  NM_079796   3101   471 Rb97D-RC FBtr0100334  NM_001014677   2506   465 Rb97D-RD FBtr0100335  NM_001014676   2633   434 Rb97D-RE FBtr0100336  NM_001014675   2510   434 Rb97D-RF FBtr0100337  NM_001014674   2524   471 Rb97D-RG FBtr0100338  NM_001014673   2810   465 Rb97D-RH FBtr0100339  NM_001014672   2094   471 Rb97D-RI FBtr0100340  NM_001014671   2828   471
Additional Transcript Data & Comments
Reported size (kB)	3.1, 2.8, 2.7 (northern blot) (Karsch-Mizrachi and Haynes, 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rb97D-PA   FBpp0084462   50.8   465   9.43     NP_733172   AAN14092 Rb97D-PB   FBpp0084463   51.5   471   9.43     NP_524520   AAF56633 Rb97D-PC   FBpp0099739   50.8   465   9.43     NP_001014677   AAX52997 Rb97D-PD   FBpp0099740   48.1   434   9.23     NP_001014676   AAX53002 Rb97D-PE   FBpp0099741   48.1   434   9.23     NP_001014675   AAX53003 Rb97D-PF   FBpp0099742   51.5   471   9.43     NP_001014674   AAX52999 Rb97D-PG   FBpp0099743   50.8   465   9.43     NP_001014673   AAX52998 Rb97D-PH   FBpp0099744   51.5   471   9.43     NP_001014672   AAX53000 Rb97D-PI   FBpp0099745   51.5   471   9.43     NP_001014671   AAX53001
Additional Polypeptide Data & Comments
Reported size (kDa)	471, 465 (aa); 51.5, 50.8 (kD) (Karsch-Mizrachi and Haynes, 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF56633   AE014297 AAN14092   AE014297 AAX52997   AE014297 AAX52998   AE014297 AAX52999   AE014297 AAX53000   AE014297 AAX53001   AE014297 AAX53002   AE014297 AAX53003   AQ026425   BF485602   BF486754   BF487519   BF487686   BF489412   BF490508   BF491088   BF491405   BF491998   BF494712   BF495827   BF496345   BF498356   BF500544   BF501742   BF502076   BF503628   BF504526   BF506074   BF506172   BG635102   BI163761   BI169616   BI170935   BI215564   BI237373   BI238249   BI368948   BI368958   BI485593   BI632629   BI635216   BP547461   BT001320 AAN71075   BT010254 AAQ23572   CK604359   CK605168   CK605169   CO185958   CO186125   CO187184   CO189897   CO190667   CO190920   CO195472   CO267789   CO276229   CO278601   CO282003   CO282248   CO290550   CO299641   CO313725   CO318574   CO319459   CO319799   CO319846   CO322465   CO322585   CO322607   CO323665   CO324135   CO333775   EC057962   EC059832   EC063211   EC067086   EC071514   EC073212   EC079051   EC084138   EC089797   EC215720   EC217224   EC222659   EC223009   EC226252   EC228382   EC229939   EC235024   EC237145   EC240641   EC240890   EC243250   EC245387   EC245441   EC250432   EL869862   EL869863   EL882855   EV581917   GH942161   GH944505   GH949811   GH957604   GH957720   GH960475   GH962384   GH964594   GH968453   GH973012   L02106 AAA99872   L02106 AAA99873
UniProtKB/Swiss-Prot	Q02926
UniProtKB/TrEMBL	A4V3H1 A4V3G9 Q59DT6 Q6NR27
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Karsch-Mizrachi and Haynes, 1993)
Additional Descriptive Data
	Rb97D transcripts are observed at most developmental stages. The highest levels are seen in early pupae. (Karsch-Mizrachi and Haynes, 1993)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval fat body, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    118.5 Larval Midgut    33.5 Larval Hindgut    40.4 Larval Malpighian Tubules    39 Larval Fat Body    119 Larval Salivary Gland    57.7 Larval Trachea    88.825 Larval Carcass    35.25 Adult Head    61.6 Adult Eye    71.55 Adult Brain    183.8 Adult Thoracic-Abdominal Ganglion    104.2 Adult Crop    65.9 Adult Midgut    54.9 Adult Hindgut    59.9 Adult Malpighian Tubules    32.1 Adult Fat Body    37.8 Adult Salivary Gland    68.5 Adult Heart    47.45 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    23.3 Adult Ovary    152 Adult Testis    347.3 Adult Male Accessory Gland    78.7 Adult Carcass    43.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    61.6   NA  Eye    71.55   NA  Brain    183.8   118.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    104.2   NA  Crop    65.9   33.5  Midgut    54.9   40.4  Hindgut    59.9   39  Malpighian Tubules    32.1   119  Fat Body    37.8   57.7  Salivary Gland    68.5   NA  Heart    47.45   88.825  Trachea    NA   NA  VirginFemale Spermatheca    27.3   NA  InseminatedFemale Spermatheca    23.3   NA  Ovary    152   NA  Testis    347.3   NA  Male Accessory Gland    78.7   35.25  Carcass    43.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    33 central nervous system, pupae P8    34 head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    38 ovary, mated 4-day female    33 testis, mated 4-day male    59 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (85) central nervous system, larvae L3  (33) central nervous system, pupae P8  (34) head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8  26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (38) ovary, mated 4-day female  (33) testis, mated 4-day male  (59) accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    33 central nervous system, pupae P8    34 head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    38 ovary, mated 4-day female    33 testis, mated 4-day male    59 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    33 central nervous system, pupae P8    34 head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    38 ovary, mated 4-day female    33 testis, mated 4-day male    59 accessory gland, mated 4-day male    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    33 central nervous system, pupae P8    34 head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    38 ovary, mated 4-day female    33 testis, mated 4-day male    59 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (85) central nervous system, larvae L3  (33) central nervous system, pupae P8  (34) head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8  26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female  (38) ovary, mated 4-day female  (33) testis, mated 4-day male  (59) accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    33 central nervous system, pupae P8    34 head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    38 ovary, mated 4-day female    33 testis, mated 4-day male    59 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    85 central nervous system, larvae L3    33 central nervous system, pupae P8    34 head, virgin 1-day female    16 head, virgin 4-day female    21 head, virgin 20-day female    9 head, mated 1-day female    15 head, mated 4-day female    14 head, mated 20-day female    8 head, mated 1-day male    19 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    6 fat body, larvae L3 wandering    5 fat body, white prepupae    16 fat body, pupae P8    26 carcass, larvae L3 wandering    16 carcass, 1-day adult    7 carcass, 4-day adult    8 carcass, 20-day adult    8 ovary, virgin 4-day female    38 ovary, mated 4-day female    33 testis, mated 4-day male    59 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr  (27) pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr  27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24 embryo 02-04hr    12 embryo 04-06hr    20 embryo 06-08hr    21 embryo 08-10hr    18 embryo 10-12hr    17 embryo 12-14hr    15 embryo 14-16hr    11 embryo 16-18hr    9 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    8 larva L1    8 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    14 larva L3 puffstage 7-9    16 white prepupae new    19 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    13 pupae 4d postWPP    9 adult male 01day    14 adult male 05day    22 adult male 30day    19 adult female 01day    9 adult female 05day    14 adult female 30day    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    30 embryonic 1182-4H    9 embryonic GM2    26 embryonic Kc167    44 embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2    26 wing disc ML-DmD8    28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (86) Schneider line 2 Sg4  (30) embryonic 1182-4H    9 embryonic GM2  26 embryonic Kc167  (44) embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2  26 wing disc ML-DmD8  (28) wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2  (31) ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    30 embryonic 1182-4H    9 embryonic GM2    26 embryonic Kc167    44 embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2    26 wing disc ML-DmD8    28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    30 embryonic 1182-4H    9 embryonic GM2    26 embryonic Kc167    44 embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2    26 wing disc ML-DmD8    28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    30 embryonic 1182-4H    9 embryonic GM2    26 embryonic Kc167    44 embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2    26 wing disc ML-DmD8    28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (86) Schneider line 2 Sg4  30 embryonic 1182-4H    9 embryonic GM2  26 embryonic Kc167  (44) embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2  26 wing disc ML-DmD8  28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3  (35) eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2  31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    30 embryonic 1182-4H    9 embryonic GM2    26 embryonic Kc167    44 embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2    26 wing disc ML-DmD8    28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    30 embryonic 1182-4H    9 embryonic GM2    26 embryonic Kc167    44 embryonic S1    23 embryonic S3    22 leg disc CME L1    20 wing disc CME-W2    26 wing disc ML-DmD8    28 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    18 wing disc ML-DmD21    18 wing disc ML-DmD32    20 haltere disc ML-DmD17-c3    35 eye-antennal disc ML-DmD11    14 antennal disc ML-DmD20-c5    22 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    23 tumorous blood cells mbn2    31 ovary fGS/OSS    16 ovary OSC    17 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    6 heat shock, 4-day adult    12 Cadmium 50 mM 6 hrs, larvae L3    12 Cadmium 50 mM 12 hrs, larvae L3    16 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    13 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    18 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • RE34656 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004903 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6354-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Sterility Allele male sterile Rb97D1 male sterile | recessive Rb97D1 Rb97D2 Phenotype manifest in Allele axoneme Rb97D2 nucleus & spermatid Rb97D1
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Rb97D Class Mutagen Stocks Known lesion Rb97D1 loss of function allele P-element activity Delta2-3 1 Yes Rb97D2 P-element activity 0 Yes Rb97DEP3131 P-element activity 0 -- Rb97DK81-4 Delta2-3 0 Yes Rb97DK81-5 Delta2-3 0 Yes Rb97DK81-6 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rb97D Class Mutagen Stocks Known lesion Rb97DJF01289 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rb97DJF01290 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rb97DKK110966 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rb97DGD11898 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rb97Dt1.781 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC496 (Christensen et al., 2008.4.15) Df(3R)BSC524 (Christensen et al., 2008.6.11) Df(3R)ms(3)K81-4 (Yasuda et al., 1995) Df(3R)ms(3)K81-5 (Yasuda et al., 1995) Df(3R)ro80b (Cook and Carpenter, 2002) Df(3R)ro-XB3 (Strutt and White, 1994, Yasuda et al., 1995) Df(3R)Tl-I (Cook and Carpenter, 2002, Karsch-Mizrachi and Haynes, 1993, Castrillon et al., 1993) Df(3R)Tl-P (Spradling et al., 1999, Cook and Carpenter, 2002, BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)CC1.2 (Strutt and White, 1994) Df(3R)Espl3 (Cook and Carpenter, 2002) Df(3R)M1.1 (Strutt and White, 1994) Df(3R)ME61 (Cook and Carpenter, 2002) Df(3R)ms(3)K81-2 (Yasuda et al., 1995) Df(3R)ms(3)K81-3 (Yasuda et al., 1995) Df(3R)rox4 (Yasuda et al., 1995) Df(3R)T2.1 (Strutt and White, 1994) Df(3R)Tl-X (Cook and Carpenter, 2002, Karsch-Mizrachi and Haynes, 1993) Df(3R)V2.1 (Strutt and White, 1994) Df(3R)X3.1 (Strutt and White, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11898} NA P{KK110966} NA P{TRiP.JF01289} NA P{TRiP.JF01290} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Rb97D1 No insertion of mobile activating element P{EP}Rb97DEP3131 NA miscellaneous insertions P{?PZ}Rb97D2 NA P{?PZ}Rb97DK81-6 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
spermatid development inferred from mutant phenotype (Castrillon et al., 1993)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
spermatogenesis non-traceable author statement (Swiss-Prot Project Members, 1993.7.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Rb97D - CG10777 experimental knowledge based (Guruharsha et al., 2011) Rb97D - CG43444 experimental knowledge based (Guruharsha et al., 2011) Rb97D - CG4622 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rb97D - CG7272 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rb97D - ZAP3 experimental knowledge based (Guruharsha et al., 2011) Rb97D - vkg experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rb97D allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68122 DroID - A comprehensive database of gene and protein interactions. • FBgn0004903 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43231
Orthologs
OrthoDB Orthologs (153) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FXRTP Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG65TBJ9 Arthropod inclusive ortholog search EOG6X69RF Metazoa inclusive ortholog search EOG6G20CW
Orthologs in Drosophila Species (EOG6FXRTP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rb97D     Drosophila simulans   Dsim\GD18114 Y   Drosophila sechellia   Dsec\GM10160 Y   Drosophila erecta   Dere\GG12167 Y   Drosophila yakuba   Dyak\GE10609 Y   Drosophila ananassae   Dana\GF18563 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19533 Y   Drosophila persimilis   Dper\GL27263 Y   Drosophila willistoni   Dwil\GK13742 Y   Drosophila virilis   Dvir\GJ22593 Y   Drosophila mojavensis   Dmoj\GI24524 Y   Drosophila grimshawi   Dgri\GH23661 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG65TBJ9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41392 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008807 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19277 Y Atta cephalotes Leafcutter ant  Acep\ACEP15101 Y Linepithema humile Argentine ant  Lhum\LH16171 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17027 Y Solenopsis invicta Red fire ant  Sinv\SINV24695 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009542 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001865 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002624 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003661 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002060 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007822 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006405 Y Pediculus humanus Human body louse  Phum\PHUM050860 Y Pediculus humanus Human body louse  Phum\PHUM451750 Y Tribolium castaneum Red flour beetle  Tcas\TC004556 Y
Orthologs in non-Insect Arthropods (EOG6X69RF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307331 Y Ixodes scapularis Deer tick  Isca\ISCW011438 Y
Orthologs in non-Arthropod Metazoa (EOG6G20CW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\sqd-1 Y Caenorhabditis elegans Nematode  Cele\hrp-1 Y Caenorhabditis elegans Nematode  Cele\H28G03.1 Y Caenorhabditis elegans Nematode  Cele\msi-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022512gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008172gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015676gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020274gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026906gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002003gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007318gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017609gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024306gn Y Danio rerio Zebrafish  Drer\hnrnpd Y Danio rerio Zebrafish  Drer\hnrnpa1 Y Danio rerio Zebrafish  Drer\zgc:66127 Y Danio rerio Zebrafish  Drer\dazap1 Y Danio rerio Zebrafish  Drer\msi2a Y Danio rerio Zebrafish  Drer\hnrnpab Y Danio rerio Zebrafish  Drer\msi2b Y Danio rerio Zebrafish  Drer\hnrnpa0l Y Danio rerio Zebrafish  Drer\hnrpdl Y Danio rerio Zebrafish  Drer\zgc:77366 Y Danio rerio Zebrafish  Drer\msi1 Y Danio rerio Zebrafish  Drer\zgc:77052 Y Danio rerio Zebrafish  Drer\hnrnpa3 Y Danio rerio Zebrafish  Drer\hnrnpa0 Y Xenopus tropicalis Western clawed frog  Xtro\dazap1 Y Xenopus tropicalis Western clawed frog  Xtro\msi1 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpd Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa2b1 Y Xenopus tropicalis Western clawed frog  Xtro\hnrpdl Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa0 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa1 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa3 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpab Y Gallus gallus Domestic chicken  Ggal\DAZAP1 Y Gallus gallus Domestic chicken  Ggal\HNRNPA0 Y Gallus gallus Domestic chicken  Ggal\HNRNPA2B1 Y Gallus gallus Domestic chicken  Ggal\HNRNPAB Y Gallus gallus Domestic chicken  Ggal\HNRNPA3 Y Gallus gallus Domestic chicken  Ggal\HNRPDL Y Gallus gallus Domestic chicken  Ggal\MSI2 Y Gallus gallus Domestic chicken  Ggal\HNRNPD Y Gallus gallus Domestic chicken  Ggal\MSI2 Y Mus musculus House mouse  Mmus\Gm6793 Y Mus musculus House mouse  Mmus\Dazap1 Y Mus musculus House mouse  Mmus\Hnrnpa3 Y Mus musculus House mouse  Mmus\Hnrpdl Y Mus musculus House mouse  Mmus\Hnrnpa1 Y Mus musculus House mouse  Mmus\Gm7551 Y Mus musculus House mouse  Mmus\Gm8991 Y Mus musculus House mouse  Mmus\Msi1 Y Mus musculus House mouse  Mmus\ENSMUSG00000004980 Y Mus musculus House mouse  Mmus\Hnrnpab Y Mus musculus House mouse  Mmus\Rbm31y Y Mus musculus House mouse  Mmus\Hnrnpa0 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031608 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021254 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000013650 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030250 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032168 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023438 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031972 Y Rattus norvegicus Norway rat  Rnor\Msi1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031316 Y Rattus norvegicus Norway rat  Rnor\Hnrpdl Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021280 Y Rattus norvegicus Norway rat  Rnor\RGD1564416 Y Rattus norvegicus Norway rat  Rnor\Msi2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025891 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024652 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042093 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021929 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032584 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017651 Y Rattus norvegicus Norway rat  Rnor\Dazap1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029641 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039436 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005951 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000007252 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027915 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021986 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024895 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042377 Y Rattus norvegicus Norway rat  Rnor\Hnrnpa2b1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011100 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005671 Y Rattus norvegicus Norway rat  Rnor\Hnrnpa1 Y Rattus norvegicus Norway rat  Rnor\Hnrpd Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017364 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029434 Y Rattus norvegicus Norway rat  Rnor\Hnrnpab Y Rattus norvegicus Norway rat  Rnor\LOC100360986 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039876 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029531 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033211 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042924 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043173 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039983 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038905 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033182 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027605 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022655 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025482 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029898 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030901 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032616 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027006 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038392 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022285 Y Homo sapiens Human  Hsap\HNRNPA0 Y Homo sapiens Human  Hsap\DAZAP1 Y Homo sapiens Human  Hsap\HNRNPA2B1 Y Homo sapiens Human  Hsap\ENSG00000197451 Y Homo sapiens Human  Hsap\HNRNPD Y Homo sapiens Human  Hsap\MSI2 Y Homo sapiens Human  Hsap\HNRNPA1L2 Y Homo sapiens Human  Hsap\ENSG00000135486 Y Homo sapiens Human  Hsap\HNRNPA3 Y Homo sapiens Human  Hsap\HNRPDL Y Homo sapiens Human  Hsap\MSI1 Y
Human Orthologs (11)
Gene OMIM HGNC Hsap\HNRNPA0     Hsap\DAZAP1     Hsap\HNRNPA2B1     Hsap\ENSG00000197451     Hsap\HNRNPD     Hsap\MSI2     Hsap\HNRNPA1L2     Hsap\ENSG00000135486     Hsap\HNRNPA3     Hsap\HNRPDL     Hsap\MSI1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18114 Drosophila sechellia Dsec\GM10160 Drosophila erecta Dere\GG12167 Drosophila yakuba Dyak\GE10609 Drosophila ananassae Dana\GF18563 Drosophila pseudoobscura pseudoobscura Dpse\GA19533 Drosophila persimilis Dper\GL27263 Drosophila willistoni Dwil\GK13742 Drosophila virilis Dvir\GJ22593 Drosophila mojavensis Dmoj\GI24524 Drosophila grimshawi Dgri\GH23661
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	31333 y1 v1; P{TRiP.JF01290}attP2 31332 y1 v1; P{TRiP.JF01289}attP2/TM3, Ser1 11782 ry506 P{PZ}Rb97D1/TM3, ryRK Sb1 Ser1
VDRC	v102159 P{KK110966}VIE-260B
Genomic Clones ( 1 )
	BACR24O14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 96 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT15526 RE34656
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03434 AT04714 AT06101 AT08448 AT08573 AT09489 AT10119 AT12831 AT17279 AT17694 AT19530 AT21273 AT22372 AT22720 AT25529 AT27001 AT27750 AT28142 AT28858 AT31578 RE03257 RE10845 RE12567 RE22102 RE33591 RE55012 RE55024 RE68956 SD16502 SD26455 UT01125
Other clones	18601 38874 43969 44788 50169 55684 62779 64534 106516 145255 173690 176193 176274 194233 283029 CK01.14A.F9 CK01.16A.F3 CK01.31A.C4 CK01.56B.H5 CK01.60D.H11 CK01.131A.C10 CK01.131A.G8 CK01.146A.G10 Dmel_dig_019979_0602_2431 EC40431 EK014721 EK016022 EK026942 EK045531 EK049024 EK050109 EK074302 EK120057 EK130536 EK151839 EK159317 EK159957 EK176022 EK188205 EK188436 EK188502 EK191057 EK192745 EK233913 EK272920 EK278240 EK280836 EK281033 EK307943 FGH117B12 IP01980 IP12541 RP004052457 RP004054777 RP004180671 RP004240223 RP004258846 RP004388385 RP004454948 RP004501139 RP004525648 RP004545252 UT01728
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004903 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43231
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The distribution of Rb97D protein in the testes has been examined. (Heatwole and Haynes, 1996) Rb97D males are sterile, abnormalities in dynein protein expression render sperm immotile. (Haynes et al., 1995) Postmeiotic differentiation defect. (Castrillon et al., 1993) Identified by reduced stringency hybridization to the ribonucleoprotein motifs of Hrb98DE. Multiple transcripts are present at varying levels throughout development, but mutant analysis reveals that the Hrb97D product is required for male fertility. (Karsch-Mizrachi and Haynes, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079796 NM_170293 NM_001014671 NM_001014672 NM_001014673 NM_001014674 NM_001014675 NM_001014676 NM_001014677 RefSeq (Proteins) • NP_524520 NP_733172 NP_001014671 NP_001014672 NP_001014673 NP_001014674 NP_001014675 NP_001014676 NP_001014677 DDBJ / EMBL / GenBank • AAA99872 AAA99873 AAF56633 AAF56633.1 AAN14092 AAN14092.1 AAN71075 AAQ23572 AAX52997 AAX52998 AAX52999 AAX53000 AAX53001 AAX53002 AAX53003 AQ026425 BF500544 BI238249 BT001320 BT010254 L02106 Entrez Gene - A searchable database of RefSeq genes. • 43231 UniProtKB/Swiss-Prot • Q02926 UniProtKB/TrEMBL • A4V3G9 A4V3H1 Q6NR27 Q59DT6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE34656
Linkouts
	BioGRID - A database of protein and genetic interactions • 68122 DroID - A comprehensive database of gene and protein interactions. • FBgn0004903 DRSC - Results from RNAi screens. • FBgn0004903 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004903 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6354-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004903 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43231 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43231 modMine - Data generated by the modENCODE project. • FBgn0004903
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG6354 (Keleman et al., 2009.8.5, Ni et al., 2008) Hrb97D   ms(3)03445   R16   Rb97D (Raja and Renkawitz-Pohl, 2005, Christensen et al., 2008.4.15, Christensen et al., 2008.6.11, Hempel et al., 2006) rb97d (Sofola et al., 2007) Rb97D1 (Yasuda et al., 1997) rbf (Morris et al., 2002) RBP97D (Sofola et al., 2007)
Name Synonym	Ribonuclear protein at 97D
Secondary FlyBase IDs
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
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