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Gene Dmel\14-3-3ζ

General Information
Symbol	Dmel\14-3-3ζ	Species	D. melanogaster
Name	14-3-3ζ	Annotation symbol	CG17870
Feature type	protein_coding_gene	FlyBase ID	FBgn0004907
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	leo, 14-3-3, 14-3-3zeta, par-5, 549, D14-3-3ζ
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46E6-46E8	Sequence location	2R:5,987,184..5,997,192 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene 14-3-3ζ is referred to in FlyBase by the symbol Dmel\14-3-3ζ (CG17870, FBgn0004907). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein heterodimerization activity; protein homodimerization activity. There is experimental evidence that it is involved in the biological process: germarium-derived oocyte fate determination; mitotic cell cycle, embryonic; learning or memory; protein stabilization; chromosome segregation; oocyte microtubule cytoskeleton polarization; protein folding. 51 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell; denticle belt. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: 14-3-3 domain; 14-3-3 protein; 14-3-3 protein, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1625148_s_at completely aligns to an exonic region of only a subset of 6 of the 10 FlyBase-annotated transcript isoforms of 14-3-3zeta. Gene sequence location is 2R:5987184..5997192.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Karam et al., 2010, PLoS Genet. 6(6): e1000975 Controlled Vocabulary Terms mushroom body beta-lobe mushroom body spur calyx of adult mushroom body mushroom body alpha-lobe mushroom body gamma-lobe mushroom body beta'-lobe mushroom body alpha'-lobe Sequence features HFA05028 BKN29378
FB2011_10	References Messaritou et al., 2009, FEBS Lett. 583(17): 2934--2938 Alleles 14-3-3zeta[III.Scer\UAS.T:Zzzz\FLAG]
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46E6-46E8   Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
Experimentally Determined Cytological Location
Cytogenetic map Notes References 46E4-46E8   (determined by in situ hybridisation)   (Spradling et al., 1999) 46E-46E   (determined by in situ hybridisation)   (Skoulakis and Davis, 1996) 46E-46F   (determined by in situ hybridisation)   (Skoulakis, 1995) 46E4-46E8     (BDGP Project Members, 1994-1999) 46E-46E   (determined by in situ hybridisation)   (Swanson and Ganguly, 1992) 46E-46E   (determined by in situ hybridisation)   (Hyde et al., 1990) 46E-46E   (determined by in situ hybridisation)   (Levy et al., 1982) 46C8-46F6   Complementation data from unspecified deficiency chromosomes.   (Goldstein et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\14-3-3ζ for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) 14-3-3zeta-RA FBtr0088413  NM_165741   1757   248 14-3-3zeta-RB FBtr0088412  NM_165742   3076   248 14-3-3zeta-RC FBtr0088419  NM_165743   2970   248 14-3-3zeta-RD FBtr0088414  NM_057537   2970   248 14-3-3zeta-RE FBtr0088415  NM_165740   2955   248 14-3-3zeta-RF FBtr0088416  NM_165744   1742   248 14-3-3zeta-RG FBtr0088417  NM_165745   3050   248 14-3-3zeta-RH FBtr0088418  NM_206070   2955   248 14-3-3ζ-RI FBtr0100182  NM_001014516   1027   248 14-3-3ζ-RJ FBtr0100183  NM_001014515   1757   248
Additional Transcript Data & Comments
Reported size (kB)	2.9, 1.9, 1.0 (northern blot) (Skoulakis and Davis, 1996) 2.9, 1.0 (unknown); 1.9 (northern blot) (Swanson and Ganguly, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein 14-3-3zeta-PA   FBpp0087501   28.3   248   4.56     NP_724885   AAF58843 14-3-3zeta-PB   FBpp0087500   28.3   248   4.56     NP_724886   AAM71062 14-3-3zeta-PC   FBpp0089338   28.3   248   4.74     NP_724887   AAM71063 14-3-3zeta-PD   FBpp0087502   28.2   248   4.50     NP_476885   AAM71060 14-3-3zeta-PE   FBpp0087503   28.2   248   4.50     NP_724884   AAM71061 14-3-3zeta-PF   FBpp0087504   28.3   248   4.74     NP_724888   AAM71064 14-3-3zeta-PG   FBpp0087505   28.3   248   4.56     NP_724889   AAF58842 14-3-3zeta-PH   FBpp0089337   28.3   248   4.56     NP_995792   AAS64884 14-3-3ζ-PI   FBpp0099539   28.3   248   4.56     NP_001014516   AAX52716 14-3-3ζ-PJ   FBpp0099540   28.2   248   4.50     NP_001014515   AAX52715
Additional Polypeptide Data & Comments
Reported size (kDa)	248 (aa); 29 (kD observed) (Kockel et al., 1997, Skoulakis and Davis, 1996) 248 (aa) (Swanson and Ganguly, 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • 14-3-3 protein (IPR000308) 14-3-3 protein, conserved site (IPR023409) 14-3-3 domain (IPR023410)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201187   AA202254   AA246652   AA264638   AA264828   AA390676   AA438618   AA536571   AA538817   AA540738   AA567934   AA694865   AA695282   AA696941   AA697335   AA698422   AA736190   AA801656   AA802747   AA803157   AA803797   AA803886   AA803889   AA817567   AA821108   AA821199   AA821201   AA940737   AA942102   AA948947   AA949021   AA949769   AA950118   AA950363   AA950650   AE013599 AAF58842   AE013599 AAF58843   AE013599 AAM71060   AE013599 AAM71061   AE013599 AAM71062   AE013599 AAM71063   AE013599 AAM71064   AE013599 AAS64884   AE013599 AAX52715   AE013599 AAX52716   AC005469   AC005974   AI063112   AI063217   AI063224   AI063289   AI063961   AI063963   AI064599   AI064611   AI106636   AI106961   AI107028   AI107159   AI107175   AI107321   AI107949   AI108709   AI109203   AI109383   AI109801   AI110088   AI110098   AI113786   AI114064   AI114356   AI134099   AI134226   AI134241   AI238001   AI238034   AI238802   AI257995   AI258064   AI259751   AI260492   AI292538   AI292832   AI293013   AI293944   AI294199   AI294823   AI297597   AI386496   AI388020   AI403491   AI404119   AI404171   AI406226   AI455891   AI513041   AI513325   AI513347   AI515002   AI515277   AI515373   AI516206   AI516934   AI517375   AI517434   AI517524   AI517532   AI519273   AI519383   AI520350   AI532041   AI534656   AI542081   AI542237   AI542694   AI543055   AI543390   AI546584   AI946489   AQ025662   AW942482   AY095521 AAM12253   AY231656   AY232035   AY432667   BG634265   BG637054   BG638980   BG639789   BG640374   BG640728   BH840513   BI142231   BI161616   BI161617   BI161640   BI161641   BI162594   BI162595   BI163129   BI164177   BI164303   BI164913   BI164967   BI165501   BI165635   BI165689   BI165815   BI165849   BI165893   BI165960   BI166483   BI166817   BI167081   BI167736   BI168549   BI169175   BI169324   BI169357   BI171528   BI171631   BI171915   BI172345   BI173381   BI213154   BI213254   BI213519   BI213659   BI214565   BI214630   BI215259   BI215398   BI229330   BI231001   BI231214   BI231377   BI231384   BI231688   BI232005   BI233161   BI234137   BI234178   BI234792   BI235550   BI235990   BI236058   BI236186   BI236467   BI237493   BI237891   BI238983   BI239023   BI239738   BI240248   BI241825   BI243501   BI351676   BI354636   BI355528   BI356079   BI356786   BI356841   BI356889   BI357099   BI357100   BI357231   BI357249   BI358531   BI361755   BI362316   BI362348   BI363250   BI363393   BI364211   BI364312   BI364449   BI364976   BI365795   BI365898   BI366161   BI366484   BI366493   BI369692   BI370204   BI370221   BI370744   BI371954   BI372124   BI372213   BI372587   BI375017   BI375040   BI375424   BI375433   BI482507   BI482760   BI483679   BI483809   BI483850   BI484477   BI484963   BI485828   BI486750   BI486816   BI563409   BI564561   BI564632   BI564764   BI565201   BI565556   BI565670   BI566192   BI566294   BI566552   BI567080   BI567312   BI569399   BI569400   BI569578   BI570512   BI573281   BI573282   BI573677   BI573678   BI573754   BI573755   BI575036   BI575939   BI577828   BI577895   BI578642   BI579908   BI580953   BI580954   BI582149   BI582227   BI582418   BI582421   BI582541   BI582692   BI582874   BI583254   BI583260   BI583729   BI583825   BI583953   BI584459   BI585658   BI585767   BI585782   BI587021   BI587664   BI587793   BI587854   BI588324   BI588344   BI588456   BI589169   BI589732   BI589750   BI589781   BI590145   BI590275   BI590649   BI592018   BI592291   BI592716   BI593009   BI604585   BI605520   BI605573   BI605679   BI606138   BI607852   BI608577   BI608613   BI608999   BI609540   BI609978   BI610092   BI610145   BI610686   BI611390   BI611592   BI611675   BI612779   BI612810   BI613148   BI613343   BI613506   BI614373   BI614530   BI614792   BI615139   BI615612   BI615966   BI616264   BI616344   BI616619   BI616938   BI617095   BI617363   BI617637   BI617795   BI617902   BI618105   BI618816   BI619066   BI619630   BI619899   BI619963   BI620847   BI621646   BI621938   BI621945   BI623992   BI624861   BI624977   BI625604   BI626232   BI628488   BI628511   BI628534   BI628670   BI628872   BI629143   BI629756   BI630193   BI631205   BI631689   BI631749   BI632995   BI633410   BI633430   BI633466   BI634791   BI635136   BI635785   BI636959   BI637861   BI638336   BI638503   BI639197   BI639371   BI641130   BI641933   BP541066   BP541067   BP541227   BP541228   BP542259   BP543673   BP543674   BP544901   BP544902   BP545267   BP546102   BP546400   BP546407   BP546498   BP546596   BP546845   BP547574   BP547829   BP547982   BP548046   BP548134   BP549073   BP549074   BP549677   BP549678   BP550371   BP550372   BP550774   BP551538   BP551582   BP551583   BP552018   BP552019   BP552850   BP552851   BP553519   BP553520   BP556283   BP556284   BP557106   BP557107   BP557484   BP558012   BP558013   BP558112   BP558561   BP559182   BP559183   BP559220   BP559221   BQ103193   BT001855 AAN71617   BT082022   BT088441   BT099909   BX026329   BX029843   BX031037   BX049248   BX058218   CC060506   CK086539   CK131498   CK132399   CK604379   CK657272   CK658941   CK659287   CK659499   CK659659   CK661751   CL632153   CO153131   CO153362   CO153392   CO154374   CO154475   CO154586   CO155048   CO176885   CO177135   CO179554   CO187197   CO187486   CO188510   CO191053   CO191120   CO192054   CO192908   CO195862   CO196641   CO263339   CO263971   CO265057   CO265527   CO265535   CO265545   CO266871   CO267041   CO267657   CO269836   CO270267   CO271144   CO271761   CO271883   CO272440   CO277274   CO279708   CO282908   CO283135   CO283587   CO288144   CO288330   CO288561   CO288729   CO289324   CO289707   CO290046   CO290134   CO290143   CO291161   CO292598   CO295369   CO296098   CO300293   CO302021   CO302777   CO303470   CO305953   CO306430   CO306844   CO308265   CO308684   CO308947   CO314402   CO315990   CO316383   CO316602   CO318151   CO320862   CO322417   CO322800   CO323355   CO326523   CO328476   CO328718   CO329983   CO330255   CO331726   CO331869   CO332296   CO332583   CO335524   CO335958   CO335963   CO336991   CO337798   CO339090   CO340194   CO340422   CO340425   CO340482   CO340618   CO341099   CO341442   CO341520   CO342168   CR938401   DN153806   DQ440258   EC059251   EC061301   EC061387   EC062151   EC063717   EC064157   EC065193   EC065823   EC067732   EC068872   EC074268   EC074605   EC074703   EC075097   EC075514   EC077398   EC077614   EC077648   EC081490   EC081698   EC084390   EC086752   EC087154   EC088875   EC089405   EC090543   EC090614   EC196619   EC198236   EC199234   EC200489   EC200601   EC201134   EC201359   EC203158   EC203392   EC204607   EC204661   EC204780   EC209946   EC210077   EC215345   EC223132   EC227524   EC229704   EC230000   EC237966   EC238262   EC239764   EC241062   EC245177   EC247231   EC248592   EC249183   EC249640   EC250779   EC251031   EC251592   EC252139   EC254741   EC255851   EC255865   EC256144   EC257025   EC258719   EC261381   EC261499   EC261589   EC261768   EC262826   EC263648   EC263828   EC263857   EC264090   EC266345   EC266462   EC266580   EC266815   EC267405   EC267614   EL873489   EL877376   EL882705   EV575254   EV575728   EV576948   EV577313   EV578038   EV579760   EV581665   EV585533   EV586706   EV588820   EV591852   EV592500   EV592729   EV594599   EV595026   EV595827   EV596440   EV596878   GH944060   GH945830   GH947331   GH947903   GH948751   GH948928   GH949136   GH950191   GH950298   GH950480   GH951611   GH951674   GH951962   GH953692   GH956337   GH960730   GH961159   GH963974   GH967122   GH967414   GH967444   GH968656   GH969961   GH970150   GH971702   GH974563   GH975150   GH976006   GH976918   GH978444   GH979400   GH981735   GH983693   GH984701   M77518 AAA28324   Y12573 CAA73152   Y12573 CAA73153   Z32177
UniProtKB/Swiss-Prot	P29310
UniProtKB/TrEMBL	Q8SWR6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References deletion 14-3-3zetaE16] 2R:5,987,030..5,988,993 comment=Imprecise excision of the \P{PZ}\ element, deleting 1957bp, including exons I and I'. evidence=experimental (Kockel et al., 1997)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   lamina   (Swanson and Ganguly, 1992) optic lobe   (Swanson and Ganguly, 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Kockel et al., 1997) ventral nerve cord   (Swanson and Ganguly, 1992) larval stage   embryonic/larval central nervous system   (Kockel et al., 1997) third instar larval stage   morphogenetic furrow | posterior to   (Kockel et al., 1997) eye disc   (Kockel et al., 1997) adult stage   optic lobe   (Skoulakis and Davis, 1996) subesophageal ganglion   (Skoulakis and Davis, 1996) mushroom body   (Skoulakis and Davis, 1996) adult brain   (Skoulakis and Davis, 1996) antennal lobe   (Skoulakis and Davis, 1996) thoracico-abdominal ganglion   (Skoulakis and Davis, 1996) adult head   (Swanson and Ganguly, 1992) retina   (Swanson and Ganguly, 1992) adult stage & oogenesis   nurse cell   (Skoulakis and Davis, 1996) oocyte   (Skoulakis and Davis, 1996)
Additional Descriptive Data
	The 2.9kb 14-3-3ζ transcripts aredetected mainly in RNA from mid to late embryos and in adult head but notbody RNA. In situ hybridization in embryos shows that transcripts areabundant along the ventral nerve cord and less prominant elsewhere. In theadult head, transcripts are detected in regions of the optic lobe, laminaand retina. The probe used for in situ hybridization detects all three14-3-3ζ transcripts. (Swanson and Ganguly, 1992) The 1.0kb 14-3-3ζ transcript is mostabundant in early embryos. It is enriched in RNA from female vs. male andin RNA from ovary vs. body minus ovary. It is therefore assumed to bematernally inherited. (Swanson and Ganguly, 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   eye disc   (Kockel et al., 1997) morphogenetic furrow | posterior to   (Kockel et al., 1997) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   synapse   (Broadie et al., 1997) neuromuscular junction   (Broadie et al., 1997) embryonic stage 16   mushroom body neuroblast   (Noveen et al., 2000) embryonic stage 16 -- 17   cell body   (Broadie et al., 1997) Comment:reference states 16-18 hr AEL embryonic stage 17   neuron   • axon (Broadie et al., 1997) Comment:16-18 hours bouton   (Broadie et al., 1997) Comment:reference states 20 hr AEL larval stage   neuromuscular junction   (Broadie et al., 1997) embryonic/larval muscle system   (Broadie et al., 1997) bouton   (Broadie et al., 1997) synapse   (Broadie et al., 1997) adult stage   mushroom body   (Skoulakis and Davis, 1996) thoracico-abdominal ganglion   (Skoulakis and Davis, 1996) ring neuron   (Skoulakis and Davis, 1996) antennal lobe   (Skoulakis and Davis, 1996) ellipsoid body   (Skoulakis and Davis, 1996) mushroom body alpha'-lobe   (Crittenden et al., 1998) mushroom body beta'-lobe   (Crittenden et al., 1998) mushroom body alpha-lobe   (Crittenden et al., 1998) mushroom body beta-lobe   (Crittenden et al., 1998) mushroom body gamma-lobe   (Crittenden et al., 1998) mushroom body spur   (Crittenden et al., 1998) calyx of adult mushroom body   (Crittenden et al., 1998) adult stage & oogenesis   oocyte   (Skoulakis and Davis, 1996) nurse cell   (Skoulakis and Davis, 1996) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	14-3-3ζ protein is apically distributed in developing photoreceptor cells. (Kockel et al., 1997) 14-3-3ζ protein is first detected in the nervous system in 16-18hr embryos. It is observed in cell bodies, axons and synapses, including the neuromuscular junction. Over the next few hours it is partitioned to the neuromuscular junction and lost from the motor axons. By 20 hours, it is mainly in the synaptic boutons and is barely detectable in axons. In larvae, 14-3-3ζ protein is highly enriched in neuromuscular junction synaptic boutons. It is found at lower levels in surrounding tissues including the motor axons and muscle. It is expressed in both type I and type II neuromuscular junctions. It was found to be enriched in presynaptic boutons. (Broadie et al., 1997) Expression of 14-3-3ζ is within the presumptive mushroom body neuroblasts. (Noveen et al., 2000) 14-3-3ζ protein is moderately expressed in the mushroom body alpha', beta', alpha, beta and gamma lobes, in the spur and in the calyx. (Crittenden et al., 1998) 14-3-3ζ protein is abundant in the neuropil of mushroom bodies. It is detected in the dendritic projections, the cytoplasm of the perikarya, and the axonal projections that form the peduncle and lobes of mushroom body neurons. Protein is also detected in the ellipsoid body and a group of cells thought to be the ring neurons that project to the ellipsoid body. Staining is also observed in the neuropil and cell bodies of the antennal lobe. Finally, staining is observed in the thoracic ganglia and in the cytoplasm of nurse cells and oocytes. (Skoulakis and Davis, 1996)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004907    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004907 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 06-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004907 expression level Developmental Stage   Expression Level embryo 00-02hr    6829 embryo 02-04hr    8740 embryo 04-06hr    7811 embryo 06-08hr    12331 embryo 08-10hr    14998 embryo 10-12hr    18249 embryo 12-14hr    22288 embryo 14-16hr    11421 embryo 16-18hr    18712 embryo 18-20hr    16453 embryo 20-22hr    19188 embryo 22-24hr    23200 larva L1    17642 larva L2    19367 larva L3 12hr old    15034 larva L3 puffstage 1-2    11799 larva L3 puffstage 3-6    11709 larva L3 puffstage 7-9    14271 white prepupae new    12588 white prepupae 12hr    13754 white prepupae 24hr    13711 pupae 2d postWPP    14389 pupae 3d postWPP    18347 pupae 4d postWPP    10349 adult male 01day    11032 adult male 05day    9018 adult male 30day    6173 adult female 01day    7871 adult female 05day    10199 adult female 30day    9351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6829) embryo 02-04hr  (8740) embryo 04-06hr  (7811) embryo 06-08hr  (12331) embryo 08-10hr  (14998) embryo 10-12hr  (18249) embryo 12-14hr  (22288) embryo 14-16hr  (11421) embryo 16-18hr  (18712) embryo 18-20hr  (16453) embryo 20-22hr  (19188) embryo 22-24hr  (23200) larva L1  (17642) larva L2  (19367) larva L3 12hr old  (15034) larva L3 puffstage 1-2  (11799) larva L3 puffstage 3-6  (11709) larva L3 puffstage 7-9  (14271) white prepupae new  (12588) white prepupae 12hr  (13754) white prepupae 24hr  (13711) pupae 2d postWPP  (14389) pupae 3d postWPP  (18347) pupae 4d postWPP  (10349) adult male 01day  (11032) adult male 05day  (9018) adult male 30day  (6173) adult female 01day  (7871) adult female 05day  (10199) adult female 30day  (9351) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6829) embryo 02-04hr  (8740) embryo 04-06hr  (7811) embryo 06-08hr  (12331) embryo 08-10hr  (14998) embryo 10-12hr  (18249) embryo 12-14hr  (22288) embryo 14-16hr  (11421) embryo 16-18hr  (18712) embryo 18-20hr  (16453) embryo 20-22hr  (19188) embryo 22-24hr  (23200) larva L1  (17642) larva L2  (19367) larva L3 12hr old  (15034) larva L3 puffstage 1-2  (11799) larva L3 puffstage 3-6  (11709) larva L3 puffstage 7-9  (14271) white prepupae new  (12588) white prepupae 12hr  (13754) white prepupae 24hr  (13711) pupae 2d postWPP  (14389) pupae 3d postWPP  (18347) pupae 4d postWPP  (10349) adult male 01day  (11032) adult male 05day  (9018) adult male 30day  (6173) adult female 01day  (7871) adult female 05day  (10199) adult female 30day  (9351) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6829 embryo 02-04hr    8740 embryo 04-06hr    7811 embryo 06-08hr  (12331) embryo 08-10hr  (14998) embryo 10-12hr  (18249) embryo 12-14hr  (22288) embryo 14-16hr  (11421) embryo 16-18hr  (18712) embryo 18-20hr  (16453) embryo 20-22hr  (19188) embryo 22-24hr  (23200) larva L1  (17642) larva L2  (19367) larva L3 12hr old  (15034) larva L3 puffstage 1-2  (11799) larva L3 puffstage 3-6  (11709) larva L3 puffstage 7-9  (14271) white prepupae new  (12588) white prepupae 12hr  (13754) white prepupae 24hr  (13711) pupae 2d postWPP  (14389) pupae 3d postWPP  (18347) pupae 4d postWPP  10349 adult male 01day  (11032) adult male 05day    9018 adult male 30day    6173 adult female 01day    7871 adult female 05day  10199 adult female 30day    9351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6829 embryo 02-04hr    8740 embryo 04-06hr    7811 embryo 06-08hr    12331 embryo 08-10hr    14998 embryo 10-12hr    18249 embryo 12-14hr    22288 embryo 14-16hr    11421 embryo 16-18hr    18712 embryo 18-20hr    16453 embryo 20-22hr    19188 embryo 22-24hr    23200 larva L1    17642 larva L2    19367 larva L3 12hr old    15034 larva L3 puffstage 1-2    11799 larva L3 puffstage 3-6    11709 larva L3 puffstage 7-9    14271 white prepupae new    12588 white prepupae 12hr    13754 white prepupae 24hr    13711 pupae 2d postWPP    14389 pupae 3d postWPP    18347 pupae 4d postWPP    10349 adult male 01day    11032 adult male 05day    9018 adult male 30day    6173 adult female 01day    7871 adult female 05day    10199 adult female 30day    9351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004907 expression level Developmental Stage   Expression Level embryo 00-02hr    6829 embryo 02-04hr    8740 embryo 04-06hr    7811 embryo 06-08hr    12331 embryo 08-10hr    14998 embryo 10-12hr    18249 embryo 12-14hr    22288 embryo 14-16hr    11421 embryo 16-18hr    18712 embryo 18-20hr    16453 embryo 20-22hr    19188 embryo 22-24hr    23200 larva L1    17642 larva L2    19367 larva L3 12hr old    15034 larva L3 puffstage 1-2    11799 larva L3 puffstage 3-6    11709 larva L3 puffstage 7-9    14271 white prepupae new    12588 white prepupae 12hr    13754 white prepupae 24hr    13711 pupae 2d postWPP    14389 pupae 3d postWPP    18347 pupae 4d postWPP    10349 adult male 01day    11032 adult male 05day    9018 adult male 30day    6173 adult female 01day    7871 adult female 05day    10199 adult female 30day    9351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6829) embryo 02-04hr  (8740) embryo 04-06hr  (7811) embryo 06-08hr  (12331) embryo 08-10hr  (14998) embryo 10-12hr  (18249) embryo 12-14hr  (22288) embryo 14-16hr  (11421) embryo 16-18hr  (18712) embryo 18-20hr  (16453) embryo 20-22hr  (19188) embryo 22-24hr  (23200) larva L1  (17642) larva L2  (19367) larva L3 12hr old  (15034) larva L3 puffstage 1-2  (11799) larva L3 puffstage 3-6  (11709) larva L3 puffstage 7-9  (14271) white prepupae new  (12588) white prepupae 12hr  (13754) white prepupae 24hr  (13711) pupae 2d postWPP  (14389) pupae 3d postWPP  (18347) pupae 4d postWPP  (10349) adult male 01day  (11032) adult male 05day  (9018) adult male 30day  (6173) adult female 01day  (7871) adult female 05day  (10199) adult female 30day  (9351) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6829) embryo 02-04hr  (8740) embryo 04-06hr  (7811) embryo 06-08hr  (12331) embryo 08-10hr  (14998) embryo 10-12hr  (18249) embryo 12-14hr  (22288) embryo 14-16hr  (11421) embryo 16-18hr  (18712) embryo 18-20hr  (16453) embryo 20-22hr  (19188) embryo 22-24hr  (23200) larva L1  (17642) larva L2  (19367) larva L3 12hr old  (15034) larva L3 puffstage 1-2  (11799) larva L3 puffstage 3-6  (11709) larva L3 puffstage 7-9  (14271) white prepupae new  (12588) white prepupae 12hr  (13754) white prepupae 24hr  (13711) pupae 2d postWPP  (14389) pupae 3d postWPP  (18347) pupae 4d postWPP  (10349) adult male 01day  (11032) adult male 05day  (9018) adult male 30day  (6173) adult female 01day  (7871) adult female 05day  (10199) adult female 30day  (9351) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6829 embryo 02-04hr    8740 embryo 04-06hr    7811 embryo 06-08hr  12331 embryo 08-10hr  14998 embryo 10-12hr  18249 embryo 12-14hr  (22288) embryo 14-16hr  11421 embryo 16-18hr  18712 embryo 18-20hr  16453 embryo 20-22hr  19188 embryo 22-24hr  (23200) larva L1  17642 larva L2  19367 larva L3 12hr old  15034 larva L3 puffstage 1-2  11799 larva L3 puffstage 3-6  11709 larva L3 puffstage 7-9  14271 white prepupae new  12588 white prepupae 12hr  13754 white prepupae 24hr  13711 pupae 2d postWPP  14389 pupae 3d postWPP  18347 pupae 4d postWPP  10349 adult male 01day  11032 adult male 05day    9018 adult male 30day    6173 adult female 01day    7871 adult female 05day  10199 adult female 30day    9351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6829 embryo 02-04hr    8740 embryo 04-06hr    7811 embryo 06-08hr    12331 embryo 08-10hr    14998 embryo 10-12hr    18249 embryo 12-14hr    22288 embryo 14-16hr    11421 embryo 16-18hr    18712 embryo 18-20hr    16453 embryo 20-22hr    19188 embryo 22-24hr    23200 larva L1    17642 larva L2    19367 larva L3 12hr old    15034 larva L3 puffstage 1-2    11799 larva L3 puffstage 3-6    11709 larva L3 puffstage 7-9    14271 white prepupae new    12588 white prepupae 12hr    13754 white prepupae 24hr    13711 pupae 2d postWPP    14389 pupae 3d postWPP    18347 pupae 4d postWPP    10349 adult male 01day    11032 adult male 05day    9018 adult male 30day    6173 adult female 01day    7871 adult female 05day    10199 adult female 30day    9351 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004907    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004907 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004907 expression level Tissue   Expression Level Larval Central Nervous System    2143.675 Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head    1093.8 Adult Eye    1411.325 Adult Brain    2503.5 Adult Thoracic-Abdominal Ganglion    2502.2 Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2143.675) Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head  (1093.8) Adult Eye  (1411.325) Adult Brain  (2503.5) Adult Thoracic-Abdominal Ganglion  (2502.2) Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2143.675) Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head  (1093.8) Adult Eye  (1411.325) Adult Brain  (2503.5) Adult Thoracic-Abdominal Ganglion  (2502.2) Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2143.675 Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head    1093.8 Adult Eye    1411.325 Adult Brain    2503.5 Adult Thoracic-Abdominal Ganglion    2502.2 Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004907 expression level Tissue   Expression Level Larval Central Nervous System    2143.675 Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head    1093.8 Adult Eye    1411.325 Adult Brain    2503.5 Adult Thoracic-Abdominal Ganglion    2502.2 Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2143.675) Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head  (1093.8) Adult Eye  (1411.325) Adult Brain  (2503.5) Adult Thoracic-Abdominal Ganglion  (2502.2) Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2143.675) Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head  1093.8 Adult Eye  1411.325 Adult Brain  (2503.5) Adult Thoracic-Abdominal Ganglion  (2502.2) Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2143.675 Larval Midgut    36.9 Larval Hindgut    59.4 Larval Malpighian Tubules    91.9 Larval Fat Body    53.4 Larval Salivary Gland    131.2 Larval Trachea    79.775 Larval Carcass    99.05 Adult Head    1093.8 Adult Eye    1411.325 Adult Brain    2503.5 Adult Thoracic-Abdominal Ganglion    2502.2 Adult Crop    86.1 Adult Midgut    31.1 Adult Hindgut    53.7 Adult Malpighian Tubules    13.7 Adult Fat Body    49.8 Adult Salivary Gland    53.7 Adult Heart    81.15 Adult VirginFemale Spermatheca    42.4 Adult InseminatedFemale Spermatheca    45.9 Adult Ovary    8.4 Adult Testis    11 Adult Male Accessory Gland    172.9 Adult Carcass    89.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1093.8   NA  Eye    1411.325   NA  Brain    2503.5   2143.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2502.2   NA  Crop    86.1   36.9  Midgut    31.1   59.4  Hindgut    53.7   91.9  Malpighian Tubules    13.7   53.4  Fat Body    49.8   131.2  Salivary Gland    53.7   NA  Heart    81.15   79.775  Trachea    NA   NA  VirginFemale Spermatheca    42.4   NA  InseminatedFemale Spermatheca    45.9   NA  Ovary    8.4   NA  Testis    11   NA  Male Accessory Gland    172.9   99.05  Carcass    89.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004907 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17870-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal 14-3-3ζP1188 14-3-3ζP1375 14-3-3ζP2335 lethal (with 14-3-3ζP1188) 14-3-3ζP2335 lethal (with 14-3-3ζP2335) 14-3-3ζP1188 lethal (with Df(2R)X1) 14-3-3ζ5-11 14-3-3ζ07103 lethal | embryonic stage | recessive 14-3-3ζ7BL 14-3-3ζ12BL 14-3-3ζP1188 14-3-3ζP1375 lethal | recessive 14-3-3ζ07103 14-3-3ζE16 14-3-3ζP1188 14-3-3ζP1375 14-3-3ζP2355 viable 14-3-3ζ2.3 14-3-3ζ5.9 14-3-3ζ7B 14-3-3ζ9.8 14-3-3ζEY06147 14-3-3ζNP0863 14-3-3ζP1.3H 14-3-3ζR1 14-3-3ζR2 14-3-3ζX1 viable, with 14-3-3ζLI.15.hs 14-3-3ζP1375 viable, with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1375 viable, with 14-3-3ζLI.15.hs, 14-3-3ζP1375 14-3-3ζLII.2.hs viable, with 14-3-3ζLI.15.hs, 14-3-3ζP1375/14-3-3ζP1188 14-3-3ζLII.2.hs viable, with 14-3-3ζLI.15.hs, 14-3-3ζP2335/14-3-3ζP1188 14-3-3ζLII.2.hs viable, with 14-3-3ζLII.2.hs, 14-3-3ζP1375 14-3-3ζLI.15.hs viable, with 14-3-3ζLII.2.hs, 14-3-3ζP1375/14-3-3ζP1188 14-3-3ζLI.15.hs viable, with 14-3-3ζLII.2.hs, 14-3-3ζP2335/14-3-3ζP1188 14-3-3ζLI.15.hs viable, with 14-3-3ζP1375 14-3-3ζLI.15.hs viable, with 14-3-3ζP1375/14-3-3ζP1188 14-3-3ζLI.15.hs viable, with 14-3-3ζP2335/14-3-3ζP1188 14-3-3ζLI.15.hs viable, with Scer\GAL4pnr-MD237 14-3-3ζGD16467 viable (with 14-3-3ζP1188), with 14-3-3ζLI.15.hs 14-3-3ζP1375 14-3-3ζP2335 viable (with 14-3-3ζP1188), with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1375 14-3-3ζP2335 viable (with 14-3-3ζP1375), with 14-3-3ζLI.15.hs 14-3-3ζP1188 viable (with 14-3-3ζP1375), with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1188 viable (with 14-3-3ζP2335), with 14-3-3ζLI.15.hs 14-3-3ζP1188 viable (with 14-3-3ζP2335), with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1188 Sterility Allele fertile 14-3-3ζEY06147 Other Phenotypes Allele learning defective 14-3-3ζ2.3 14-3-3ζX1 learning defective, with 14-3-3ζLI.15.hs 14-3-3ζP1375 learning defective, with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1375 learning defective, with 14-3-3ζLI.15.hs, 14-3-3ζP1375 14-3-3ζLII.2.hs learning defective, with 14-3-3ζLI.15.hs, 14-3-3ζP1375/14-3-3ζP1188 14-3-3ζLII.2.hs learning defective, with 14-3-3ζLI.15.hs, 14-3-3ζP2335/14-3-3ζP1188 14-3-3ζLII.2.hs learning defective, with 14-3-3ζLII.2.hs, 14-3-3ζP1375 14-3-3ζLI.15.hs learning defective, with 14-3-3ζLII.2.hs, 14-3-3ζP1375/14-3-3ζP1188 14-3-3ζLI.15.hs learning defective, with 14-3-3ζLII.2.hs, 14-3-3ζP2335/14-3-3ζP1188 14-3-3ζLI.15.hs learning defective, with 14-3-3ζP1375 14-3-3ζLI.15.hs learning defective, with 14-3-3ζP1375/14-3-3ζP1188 14-3-3ζLI.15.hs learning defective, with 14-3-3ζP2335/14-3-3ζP1188 14-3-3ζLI.15.hs learning defective (with 14-3-3ζP1188), with 14-3-3ζLI.15.hs 14-3-3ζP1375 14-3-3ζP2335 learning defective (with 14-3-3ζP1188), with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1375 14-3-3ζP2335 learning defective (with 14-3-3ζP1375), with 14-3-3ζLI.15.hs 14-3-3ζP1188 learning defective (with 14-3-3ζP1375), with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1188 learning defective (with 14-3-3ζP2335), with 14-3-3ζLI.15.hs 14-3-3ζP1188 learning defective (with 14-3-3ζP2335), with 14-3-3ζLI.15.hs, 14-3-3ζLII.2.hs 14-3-3ζP1188 memory defective 14-3-3ζ2.3 14-3-3ζ5.9 14-3-3ζ7B 14-3-3ζ9.8 14-3-3ζP1.3H 14-3-3ζX1 memory defective (with 14-3-3ζ2.3) 14-3-3ζP1375 memory defective (with 14-3-3ζP1375) 14-3-3ζ2.3 14-3-3ζX1 memory defective (with 14-3-3ζX1) 14-3-3ζP1375 mitotic cell cycle defective | maternal effect | recessive 14-3-3ζP1188 neurophysiology defective 14-3-3ζ7BL 14-3-3ζ12BL 14-3-3ζP1188 wild-type 14-3-3ζarm.PK 14-3-3ζLI.15.hs 14-3-3ζLII.2.hs 14-3-3ζtKa Phenotype manifest in Allele border follicle cell | somatic clone 14-3-3ζP1188 denticle belt 14-3-3ζhs.PL denticle belt | germline clone 14-3-3ζP1188 embryo | germline clone | posterior 14-3-3ζhbNRE.RpII15 embryonic/first instar larval cuticle | germline clone 14-3-3ζP1188 embryonic epidermis | dorsal 14-3-3ζ12BL 14-3-3ζ7BL embryonic epidermis | lateral 14-3-3ζ12BL 14-3-3ζ7BL eye photoreceptor cell | somatic clone 14-3-3ζ07103 filzkorper | germline clone 14-3-3ζhbNRE.RpII15 follicle cell | somatic clone 14-3-3ζ12BL 14-3-3ζP1188 mitotic cell cycle | maternal effect 14-3-3ζP1188 photoreceptor cell 14-3-3ζa.sev syncytial blastoderm embryo | germline clone 14-3-3ζP1188
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of 14-3-3ζ Class Mutagen Stocks Known lesion 14-3-3ζ07103 hypomorphic allele - genetic evidence P-element activity 1 Yes 14-3-3ζ12BL loss of function allele P-element activity 1 Yes 14-3-3ζ2.3 Delta2-3 1 Yes 14-3-3ζ5-SZ-3581 1 -- 14-3-3ζCB-5683-3 1 -- 14-3-3ζEY03325 P-element activity 1 -- 14-3-3ζEY06147 P-element activity 1 -- 14-3-3ζNP0863 1 -- 14-3-3ζNP7346 1 -- 14-3-3ζP1188 hypomorphic allele - genetic evidence Delta2-3 1 Yes 14-3-3ζP1375 Delta2-3 1 Yes 14-3-3ζ12X 0 -- 14-3-3ζ5-11 ethyl methanesulfonate diepoxybutane gamma ray 0 -- 14-3-3ζ5-SZ-3096 0 -- 14-3-3ζ5.9 Delta2-3 0 Yes 14-3-3ζ7B Delta2-3 0 Yes 14-3-3ζ7BL hypomorphic allele - genetic evidence P-element activity 0 Yes 14-3-3ζ9.8 Delta2-3 0 Yes 14-3-3ζE16 P-element activity 0 Yes 14-3-3ζE73 Delta2-3 0 Yes 14-3-3ζGS-A2789 Delta2-3 0 -- 14-3-3ζKG02642 P-element activity 0 -- 14-3-3ζNP3716 0 -- 14-3-3ζP1.3H Delta2-3 P-element activity 0 Yes 14-3-3ζP2335 P-element activity 0 Yes 14-3-3ζP2355 0 -- 14-3-3ζR1 Delta2-3 0 Yes 14-3-3ζR2 Delta2-3 0 Yes 14-3-3ζunspecified 0 -- 14-3-3ζX1 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of 14-3-3ζ Class Mutagen Stocks Known lesion 14-3-3ζGD16467 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes 14-3-3ζHM04002 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 14-3-3ζJF02962 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 14-3-3ζKK109378 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes 14-3-3ζa.sev in vitro construct - regulatory fusion 0 Yes 14-3-3ζarm.PK in vitro construct - regulatory fusion 0 Yes 14-3-3ζhbNRE.RpII15 in vitro construct - regulatory fusion 0 Yes 14-3-3ζhs.PL in vitro construct - regulatory fusion 0 Yes 14-3-3ζI.Scer\UAS in vitro construct - regulatory fusion 0 Yes 14-3-3ζII.Scer\UAS in vitro construct - regulatory fusion 0 Yes 14-3-3ζIII.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes 14-3-3ζLI.15.hs in vitro construct - regulatory fusion 0 Yes 14-3-3ζLII.2.hs in vitro construct - regulatory fusion 0 Yes 14-3-3ζMM.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes 14-3-3ζMW.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes 14-3-3ζScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes 14-3-3ζsev.PK in vitro construct - regulatory fusion 0 Yes 14-3-3ζtKa in vitro construct - genomic fragment 0 Yes 14-3-3ζVDRC.cUa in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes 14-3-3ζWM.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes 14-3-3ζWW.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)E73 (Kockel et al., 1997) Df(2R)X1 (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Carney et al., 1997)
Not disrupted in	Ab(2R)55-20 (Goldstein et al., 2001) Ab(2R)89-22 (Goldstein et al., 2001) Df(2R)12 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Carney et al., 1997) Df(2R)61-25 (Goldstein et al., 2001) Df(2R)64-10 (Goldstein et al., 2001) Df(2R)71-81 (Goldstein et al., 2001) Df(2R)520 (Goldstein et al., 2001) Df(2R)eve (Goldstein et al., 2001) Df(2R)stan2 (Goldstein et al., 2001) Df(2R)X3 (Spradling et al., 1999, Goldstein et al., 2001, BDGP Project Members, 1994-1999, Carney et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-14-3-3.L} NA P{hs-14-3-3ζ.LI.15} NA P{hs-14-3-3ζ.LII.2} NA characterization construct P{14-3-3ζtKa} NA P{arm-14-3-3ζ.K} NA P{RpII15-14-3-3.hbNRE} NA P{sE.14-3-3} NA P{sE.anti-14-3-3} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}14-3-3ζEY03325 NA P{EPgy2}14-3-3ζEY06147 NA P{GSV1}14-3-3ζGS-A2789 NA insertion of enhancer trap P{lacW}l(2)SH0419SH0419 No P{lArB}14-3-3ζP1.3H No P{lArB}14-3-3ζP1188 No P{lArB}14-3-3ζP1375 No P{PZ}14-3-3ζ07103 No miscellaneous insertions P{?lArB}14-3-3ζ7B NA P{RS3}14-3-3ζCB-5683-3 NA P{RS5}14-3-3ζ5-SZ-3096 NA P{RS5}14-3-3ζ5-SZ-3581 NA P{SUPor-P}14-3-3ζKG02642 NA P{UASp-YFP.Rab2.Q65L}25 NA P{unk}14-3-3ζP2335 NA insertion of enhancer trap binary system P{GawB}14-3-3ζNP0863 No P{GawB}14-3-3ζNP3716 No P{GawB}14-3-3ζNP7346 No
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Slob (Zhou et al., 1999) protein heterodimerization activity inferred from physical interaction with 14-3-3ε (Messaritou et al., 2010) protein homodimerization activity inferred from direct assay (Messaritou et al., 2010)
Biological Process
CV term Evidence References
chromosome segregation inferred from mutant phenotype (Su et al., 2001) germarium-derived oocyte fate determination inferred from genetic interaction with 14-3-3ε (Benton et al., 2002) learning or memory inferred from mutant phenotype (Philip et al., 2001) mitotic cell cycle, embryonic inferred from mutant phenotype (Su et al., 2001) oocyte microtubule cytoskeleton polarization inferred from genetic interaction with 14-3-3ε (Benton et al., 2002) protein folding inferred from direct assay (Yano et al., 2006) inferred from mutant phenotype (Yano et al., 2006) protein stabilization inferred from direct assay (Yano et al., 2006) inferred from mutant phenotype (Yano et al., 2006)
Cellular Component
CV term Evidence References
germline ring canal inferred from direct assay (Benton et al., 2002) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
protein domain specific binding inferred from electronic annotation with InterPro:IPR000308 (FlyBase Curators et al., 2004-) protein kinase C inhibitor activity inferred from sequence or structural similarity with UniProtKB:P35215 (FlyBase, 1992-) non-traceable author statement (Sokolowski, 2001) tryptophan hydroxylase activator activity inferred from sequence or structural similarity with UniProtKB:P35215 (FlyBase, 1992-)
Biological Process
CV term Evidence References
activation of tryptophan 5-monooxygenase activity inferred from sequence or structural similarity with UniProtKB:P35215 (FlyBase, 1992-) cell proliferation non-traceable author statement (Swiss-Prot Project Members, 1992.12.1) compound eye photoreceptor cell differentiation non-traceable author statement (Swiss-Prot Project Members, 1992.12.1) learning or memory non-traceable author statement (Sokolowski, 2001) olfactory learning non-traceable author statement (Roman and Davis, 2001) Ras protein signal transduction inferred from sequence or structural similarity with Saccharomyces BMH2 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1992.12.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Su et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions 14-3-3ζ allele Gene References 14-3-3ζ2.3 14-3-3ε (Chang and Rubin, 1997) 14-3-3ζ07103 Src42A (Zhang et al., 1999) 14-3-3ζE16 faf (Isaksson et al., 1997) 14-3-3ζhs.PL tor (Li et al., 1997) 14-3-3ζP1188 14-3-3ε (Benton et al., 2002, Benton and St. Johnston, 2003) tor (Li and Li, 2003) 14-3-3ζP1375 14-3-3ε (Benton and St. Johnston, 2003) 14-3-3ζP2355 14-3-3ε (Chang and Rubin, 1997) 14-3-3ζX1 14-3-3ε (Chang and Rubin, 1997) unspecified ct (Krupp et al., 2005) faf (Li et al., 1997) grim (Mueller et al., 2005) p53 (Mueller et al., 2005) rpr (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61887 DroID - A comprehensive database of gene and protein interactions. • FBgn0004907 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36059
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12019 Dere\GG24140 Dgri\GH21250 Dmoj\GI20537 Dper\GL17609 Dpse\GA24843 Dsec\GM21186 Dsim\GD12271 Dvir\GJ22386 Dwil\GK21486 Dyak\14-3-3ζ
Curated drosophilid orthologs	Dmir\14-3-3ζ   Dpse\GA14706   Dsim\14-3-3ζ (Swanson et al., 2001) Dyak\14-3-3ζ
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006885-PA Aedes aegypti (mosquito) AGAP007643-PC Anopheles gambiae (mosquito) XP_623302.2 Apis mellifera (honey bee) XP_001946750.1 Acyrthosiphon pisum (pea aphid) XP_001893666.1 Brugia malayi (roundworm nematode) BGIBMGA002644-PA Bombyx mori (silk worm) ENSBTAP00000000289 Bos taurus (bovine) CN25575 Caenorhabditis brenneri (small nematode) CBP04148 Caenorhabditis briggsae (nematode) CE03389 Caenorhabditis elegans (worm) ENSCAFP00000000820 Canis familiaris (dog) JA08447 Caenorhabditis japonica (nematode) CPIJ008589 Culex pipens (mosquito) ENSCPOP00000014893 Cavia porcellus (guinea pig) RP28162 Caenorhabditis remanei (nematode) 307391 Daphnia pulex (daphnia) ENSDARP00000027118 Danio rerio (zebra fish) ENSECAP00000019551 Equus caballus (horse) ENSGACP00000003643 Gymnopilus aculeatus (mushroom) ENSGALP00000028746 Gallus gallus (chicken) 186472 Hypsipyla robusta (cedar shoot borer) ENSP00000379287 Homo sapiens (human) 205379 Lottia gigantea (owl limpet) 38193 Monocosta brevicollis (choanoflagellate) ENSMODP00000007631 Monodelphis domestica (gray opossum) ENSMMUP00000008547 Macaca mulatta (rhesus monkey) ENSMUSP00000022894 Mus musculus (house mouse) 184113 Nematostella vectensis (starlet anemone) XP_001600046.1 Nasonia vitripennis (wasp) ENSOANP00000011631 Ornithorynchus anatinus (platypus) ENSORLP00000012885 Oryzias latipes (japanese killifish) PHUM003818-PA Pediculus humanus (human body louse) PP25958 Pristionchus pacificus (nematode) ENSPPYP00000021077 Pongo pygmaeus (orangutan) ENSPTRP00000035017 Pan troglodytes (chimpanzee) ENSRNOP00000030885 Rattus norvegicus (norway rat) Smp_009760 Schistosoma mansoni (trematode parasite) XP_001176844.1 Strongylocentrotus purpuratus (purple sea urchin) 63361 Trichoplax adhaerens (metazoa) ENSTNIP00000021062 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000027865 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000013608 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17635 NV12082 LH15036 FBgn0068545 FBgn0223478 FBgn0209499 FBgn0184006 FBgn0176067 JGI_V11_307391 FBgn0246228 FBgn0155212 FBgn0143273 FBgn0128712 FBgn0116273 FBgn0089058 CPIJ008589 BGIBMGA002644 ACYPI007203 ACYPI003154 GB12951 AGAP007643 1433Z_AEDAE PHUM507100 GLEAN_04590
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	9573 14-3-3ζ2.3; ry506 9572 w1118; 14-3-3ζ12BL/CyO 28327 y1 v1; P{TRiP.JF02962}attP2 31498 y1 v1; P{TRiP.HM04002}attP2 9402 P{lArB}14-3-3ζP1188/CyO; ry506 9403 P{lArB}14-3-3ζP1375/CyO; ry506 12335 P{PZ}14-3-3ζ07103 cn1/CyO; ry506
Kyoto	123754 w1118; P{RS3}14-3-3ζCB-5683-3 126140 w1118; P{RS5}14-3-3ζ5-SZ-3581
VDRC	v104496 P{KK109378}VIE-260B v48724 w1118; P{GD16467}v48724 v48725 w1118; P{GD16467}v48725
	More stocks available...
Genomic Clones ( 2 )
	BACR06J01 BACR09J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 632 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM13311 GM15545 LD18434 RH61958 SD12734
Other clones	yak-ad_14 yak-em_14
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT30422 GH02592 GH04087 GH04124 GH05062 GH06703 GH08325 GH08554 GH09547 GH09559 GH10242 GH11623 GH14834 GH16581 GH26454 GH27540 GH28521 GM01692 GM02089 GM02534 GM06249 GM08743 GM10322 GM14301 GM14538 GM14544 GM14603 GM14856 GM14860 GM15647 GM27696 GM31250 HL02019 HL04468 HL08140 LD08244 LD27651 LD27758 LD38795 LD40448 LD40484 LP06384 LP08285 LP16279 LP16946 RE04751 RE05419 RE05567 RE05831 RE05884 RE05964 RE07373 RE13327 RE13446 RE13813 RE14692 RE16286 RE18492 RE18936 RE20509 RE20596 RE21444 RE21786 RE23305 RE25195 RE31409 RE31966 RE43005 RE43163 RE49396 RE49555 RE51296 RE51635 RE56642 RE56666 RE57476 RE58982 RE59584 RE70287 RE71659 RH03233 RH03869 RH09611 RH10866 RH13148 RH16260 RH18053 RH21292 RH22526 RH28667 RH28746 RH29494 RH29538 RH29685 RH32346 RH35367 RH35505 RH36921 RH39027 RH42239 RH42668 RH43913 RH46166 RH46266 RH47115 RH47321 RH48648 RH50033 RH51036 RH51112 RH53730 RH56364 RH57635 RH58666 RH61863 RH63477 RH64570 RH66063 RH71535 RH72341 SD03393 SD05955 SD07591 SD08012 SD08152 SD08401 SD09135 SD09638 SD10129 SD11374 SD11870 SD14904 SD16277 SD16382 SD17266 SD18814 SD19983 SD20601 SD20805 SD21714 SD21938 SD24334 SD25612 SD26923 SD27483 SD27514 SD27560 UT01139
Other clones	14597 16573 18757 31679 32997 34013 38685 39619 57515 58941 61415 62925 63571 64981 73043 74438 74650 74957 77802 78995 80268 106460 107947 121569 125878 144839 146359 147147 147195 153033 153554 156449 156965 161331 161620 176519 176862 178147 183780 192179 214285.28 214341.39 214353.42 214405.39 214467.30 214567.44 273800 274068 274131 275233 277098 522084 522324 522359 523632 523733 523905 524379 524698 524985 527892 542451 542894 542901 562050 569644 bs27a03 CK01.24A.G3 CK01.50C.G4 CK01.62B.E5 CK01.84B.H2 CK01.93C.B2 CK01.100D.F11 CK01.104D.C4 Dmel_dig_001290_0637_3739 Dmel_dig_003240_0663_1960 Dmel_dig_004244_0593_2243 Dmel_dig_012951_0643_3522 Dmel_dig_014562_0639_1390 Dmel_dig_015716_0658_3604 Dmel_dig_017159_0608_1564 Dmel_dig_017844_0648_1933 Dmel_neb_000512_0935_3711 Dmel_neb_002614_0146_1525 Dmel_neb_006156_0643_1388 Dmel_neb_009755_0605_0372 Dmel_neb_010010_0697_3349 Dmel_neb_011120_0071_2882 Dmel_neb_012414_0593_0942 Dmel_neb_014158_0575_0757 Dmel_neb_015607_0442_3216 Dmel_neb_016392_0958_0955 EC32729 EC34763 EC41147 EK007025 EK027120 EK030005 EK040558 EK050547 EK050809 EK051456 EK052612 EK059805 EK067840 EK068245 EK068861 EK069236 EK070754 EK071839 EK072937 EK073136 EK073152 EK076336 EK088249 EK093540 EK096040 EK098126 EK102103 EK104529 EK105032 EK107209 EK123711 EK135714 EK137030 EK141415 EK142857 EK142902 EK142919 EK147817 EK148443 EK151444 EK161743 EK162329 EK163723 EK177846 EK182911 EK184863 EK188103 EK188942 EK190310 EK200539 EK209605 EK212663 EK236030 EK241634 EK249859 EK251025 EK252555 EK257237 EK259116 EK259747 EK263302 EK264764 EK265356 EK270501 EK288540 EK291244 EK294309 EK294825 EK301516 EK301861 EK303056 EK303948 EN01336 EN01828 EN01861 EN04015 EN04212 EN04420 EN05256 EN10637 EN11548 EN11554 EN13622 EN15322 EP00814 EP04048 EP09256 EP10164 EP10625 EP10628 EP10732 EP11016 EP11852 EP12445 EP12609 EP14106 FGA010D01 FGA011F12 FGC010H05 FGC021G06 FGC028D07 FGC030D04 FGH102H02 FGH106A05 FGH106B01 FGH107A10 FGH108B01 FGH110G01 FGH118D09 FGH121B06 FGH122G05 FGH123D10 FGH124D04 FGM003E04 FGM102H02 FGM206G07 FGM209A08 FGM213D10 FGM213F09 FGM216B07 FGM221B07 FGM224H03 FGM302E06 FGM307D03 FGM309E10 FGM312E03 FGM313A11 FGM315F12 FGM319D08 FGM319F04 GH02769 GH02781 GH04089 GH05075 GH05853 GH06232 GH06313 GH06473 GH06490 GH07934 GH09156 GH10739 GH11176 GH11458 GH11642 GH13951 GH14017 GH14919 GH15463 GH15836 GH16075 GH18750 GH22943 GH23721 GH23786 GH26526 GH28302 GH28373 GH28533 HL02269 IP05342 IP07322 IP12409 LD02404 LD04277 LD05642 LD08578 LD11717 LD12935 LD17332 LD20532 LD22915 LD23521 LD26140 LD28652 LD28894 LD29778 LD30555 LD33731 LD35619 LD38958 LD42001 LD45257 LD46657 LD47030 LD47173 LP01153 LP03238 LP04378 LP06530 LP07214 LP07519 LP11931 LP13896 LP17305 LP17573 LP21437 LP23440 RE01081 RE01095 RE01870 RE02454 RE03790 RE03955 RE04682 RE05631 RE05774 RE06621 RE07039 RE08188 RE09320 RE10271 RE10464 RE10507 RE16677 RE18619 RE19107 RE20447 RE21436 RE21610 RE27090 RE29449 RE29782 RE29836 RE30549 RE32049 RE32213 RE32525 RE33730 RE34219 RE35361 RE35407 RE36317 RE36949 RE39004 RE41161 RE42118 RE43086 RE43465 RE43466 RE43651 RE43671 RE45322 RE46104 RE46846 RE46885 RE48017 RE48186 RE49275 RE50186 RE51175 RE52030 RE52042 RE55958 RE59003 RE59116 RE62723 RE62755 RE63231 RE63244 RE65207 RE65506 RE66602 RE66757 RE66804 RE67584 RE68161 RE69173 RE70207 RE71580 RE72537 RE74014 RH01005 RH01478 RH01676 RH02857 RH02969 RH03211 RH03268 RH03726 RH04296 RH08966 RH09229 RH09279 RH09939 RH10483 RH11820 RH13186 RH13727 RH14336 RH14838 RH14966 RH15066 RH17589 RH17942 RH20090 RH20186 RH20474 RH20479 RH20776 RH20980 RH21803 RH21815 RH22409 RH22682 RH23670 RH25282 RH25421 RH25439 RH27277 RH27595 RH28510 RH31519 RH34041 RH36230 RH37438 RH41744 RH41783 RH42481 RH43733 RH44261 RH44682 RH45302 RH45886 RH46650 RH47686 RH48036 RH48236 RH48376 RH49736 RH50705 RH52091 RH53025 RH53737 RH56918 RH56950 RH56967 RH57175 RH57960 RH59182 RH60735 RH61319 RH61387 RH62267 RH62908 RH63344 RH64757 RH66794 RH70008 RH71156 RH71372 RP004081272 RP004125414 RP004150847 RP004154787 RP004156646 RP004170311 RP004170532 RP004175919 RP004190617 RP004191331 RP004193970 RP004203683 RP004206539 RP004210322 RP004226905 RP004229125 RP004235512 RP004245481 RP004251178 RP004259873 RP004307390 RP004329228 RP004348808 RP004360848 RP004408735 RP004431113 RP004433735 RP004451781 RP004467667 RP004467991 RP004470915 RP004509612 RP004538205 RP004542305
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004907 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36059
Antibody Information
	polyclonal (Kockel et al., 1997, Skoulakis and Davis, 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: 14-3-3ζ BEST:GH05075 (Rana, 2004.7.8) Source for merge of: 14-3-3ζ l(2)46CFe (Goldstein, 2004.3.15) Source for merge of: 14-3-3ζ l(2)46Ee (Goldstein et al., 2001)
Additional comments
Other Comments
	Both isoforms of the 14-3-3ζ gene are required acutely (as opposed to developmentally) for normal learning and memory. (Philip et al., 2001) 14-3-3ζ is required for normal chromosome separation during syncytial mitoses in the embryo. (Su et al., 2001) 14-3-3ζ can interact with and modulate slo via Slob. The binding between 14-3-3ζ and Slob is regulated by calcium/calmodulin-dependent kinase II phosphorylation. (Zhou et al., 1999) 14-3-3ζ is strongly and specifically expressed in the presynaptic boutons of the neuro muscular junction. (Broadie et al., 1997) In mutants the basic processes of synaptogenesis and excitation-secretion coupling are not perturbed, but properties of synaptic modulation such as transmission augmentation, high frequency transmission fidelity and post-tetanic potentiation (PTP) are strongly impaired. (Broadie et al., 1997) 14-3-3ζ may function in the activity-dependent regulation of synaptic vesicle dynamics to control the pool of releaseable transmitter vesicles at presynaptic fusion sites. (Broadie et al., 1997) Genetic studies indicate that 14-3-3ζ acts downstream of Ras85D and upstream of phl in the developing eye disc. (Kockel et al., 1997) 14-3-3ζ has a biological role in mushroom body-mediated learning and memory processes. (Skoulakis and Davis, 1996) Complementation group identified in an EMS and DEB screen to isolate deficiencies that uncover Jra. (Goldstein et al., 1993) The alternate 5' end of Egfr reported by Schejter et al. (Cell 46: 1091--1101) is a cloning artefact and is actually from D14-3-3 of Swanson and Ganguly (Gene 113: 183--190). (McConnell and Hodges, 1993) D14-3-3 has been characterized: gene expression is developmentally regulated and predominantly expressed in the neural tissues of the fly. (Swanson and Ganguly, 1992) Identified as a cDNA clone that is expressed exclusively or predominantly in the adult visual system. (Palazzolo et al., 1989, Hyde et al., 1990) Identified as a cDNA clone that is expressed at a low frequency in the body but abundantly in the head of the adult. (Levy et al., 1982) Developmental expression pattern of the cDNA clone is examined. (Levy and Manning, 1982)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057537 NM_165740 NM_165741 NM_165742 NM_165743 NM_165744 NM_165745 NM_206070 NM_001014515 NM_001014516 RefSeq (Proteins) • NP_476885 NP_724884 NP_724885 NP_724886 NP_724887 NP_724888 NP_724889 NP_995792 NP_001014515 NP_001014516 DDBJ / EMBL / GenBank • AA538817 AAA28324 AAF58842 AAF58842.4 AAF58843 AAF58843.3 AAM12253 AAM71060 AAM71060.1 AAM71061 AAM71061.1 AAM71062 AAM71062.1 AAM71063 AAM71063.1 AAM71063.2 AAM71064 AAM71064.2 AAN71617 AAS64884 AAS64884.1 AAX52715 AAX52716 AC005469 AC005974 AI064611 AQ025662 AW942482 AY095521 BH840513 BI564632 BI629143 BT001855 CAA73152 CAA73153 CC060506 CL632153 M77518 Y12573 Z32177 Entrez Gene - A searchable database of RefSeq genes. • 36059 UniProtKB/Swiss-Prot • P29310 UniProtKB/TrEMBL • Q8SWR6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • 14-3-3 protein (IPR000308) 14-3-3 protein, conserved site (IPR023409) 14-3-3 domain (IPR023410)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61887 DroID - A comprehensive database of gene and protein interactions. • FBgn0004907 DRSC - Results from RNAi screens. • FBgn0004907 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004907 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17870-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004907 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 84085 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36059 InParanoid A subset of ortholog calls from InParanoid. • AAEL006885-PA Aedes aegypti (mosquito) AGAP007643-PC Anopheles gambiae (mosquito) XP_623302.2 Apis mellifera (honey bee) XP_001946750.1 Acyrthosiphon pisum (pea aphid) XP_001893666.1 Brugia malayi (roundworm nematode) BGIBMGA002644-PA Bombyx mori (silk worm) ENSBTAP00000000289 Bos taurus (bovine) CN25575 Caenorhabditis brenneri (small nematode) CBP04148 Caenorhabditis briggsae (nematode) CE03389 Caenorhabditis elegans (worm) ENSCAFP00000000820 Canis familiaris (dog) JA08447 Caenorhabditis japonica (nematode) CPIJ008589 Culex pipens (mosquito) ENSCPOP00000014893 Cavia porcellus (guinea pig) RP28162 Caenorhabditis remanei (nematode) 307391 Daphnia pulex (daphnia) ENSDARP00000027118 Danio rerio (zebra fish) ENSECAP00000019551 Equus caballus (horse) ENSGACP00000003643 Gymnopilus aculeatus (mushroom) ENSGALP00000028746 Gallus gallus (chicken) 186472 Hypsipyla robusta (cedar shoot borer) ENSP00000379287 Homo sapiens (human) 205379 Lottia gigantea (owl limpet) 38193 Monocosta brevicollis (choanoflagellate) ENSMODP00000007631 Monodelphis domestica (gray opossum) ENSMMUP00000008547 Macaca mulatta (rhesus monkey) ENSMUSP00000022894 Mus musculus (house mouse) 184113 Nematostella vectensis (starlet anemone) XP_001600046.1 Nasonia vitripennis (wasp) ENSOANP00000011631 Ornithorynchus anatinus (platypus) ENSORLP00000012885 Oryzias latipes (japanese killifish) PHUM003818-PA Pediculus humanus (human body louse) PP25958 Pristionchus pacificus (nematode) ENSPPYP00000021077 Pongo pygmaeus (orangutan) ENSPTRP00000035017 Pan troglodytes (chimpanzee) ENSRNOP00000030885 Rattus norvegicus (norway rat) Smp_009760 Schistosoma mansoni (trematode parasite) XP_001176844.1 Strongylocentrotus purpuratus (purple sea urchin) 63361 Trichoplax adhaerens (metazoa) ENSTNIP00000021062 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000027865 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000013608 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /torstoll/leonrd1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36059 modMine - Data generated by the modENCODE project. • FBgn0004907 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17635 NV12082 LH15036 FBgn0068545 FBgn0223478 FBgn0209499 FBgn0184006 FBgn0176067 JGI_V11_307391 FBgn0246228 FBgn0155212 FBgn0143273 FBgn0128712 FBgn0116273 FBgn0089058 CPIJ008589 BGIBMGA002644 ACYPI007203 ACYPI003154 GB12951 AGAP007643 1433Z_AEDAE PHUM507100 GLEAN_04590
Synonyms & Secondary IDs ( 34 )
Reported As
Symbol Synonym	2G1 (Hyde et al., 1990) 4-3-3 zeta (Brody et al., 2002) 5.11 (Currie and Sullivan, 1994) 14-3-3 (Margulies et al., 2005, Collier et al., 2004, Huynh and St. Johnston, 2004, Jaramillo et al., 2004, Macara, 2004, Morley and Montgomery, 2001, Raabe, 2000, Tallman et al., 2000, Baek and Lee, 1999, Zhang et al., 1999, Rommel and Hafen, 1998, Connolly and Tully, 1998, Skoulakis, 1998, Hermon et al., 1998, Dong et al., 2007, Margolis and Borg, 2005, Xu et al., 2008, Jaramillo et al., 2006) 14-3-3zeta (Spradling et al., 1999, Giot et al., 2003, Blanco et al., 2010, Quinones-Coello, 2007, Gim et al., 2001) 14-3-3ZETA (Slack et al., 2010) 14-3-3-zeta (Wang et al., 2004) 14-3-3ζ (Yano et al., 2006, Stuart et al., 2007, Terhzaz et al., 2006, Zhang et al., 2007, Kaltenbach et al., 2007, Oh and Irvine, 2008, Hong et al., 2008, Temme et al., 2009, Oh and Irvine, 2009, Nielsen et al., 2008, Malko et al., 2006, Ren et al., 2010, Messaritou et al., 2010, Montembault et al., 2010, Przewloka et al., 2011, Franco et al., 2011, Messaritou et al., 2009, Karam et al., 2010) 14-3-3 ζ (Nie et al., 2009) 549 (Ganguly et al., 1992, Hyde et al., 1990, Levy and Manning, 1982, Levy et al., 1982, ) BEST:GH05075   CG17870 (de Morais Guedes et al., 2003, Huang et al., 2007, Stuart et al., 2007, Quinones-Coello, 2007, Terhzaz et al., 2006, Keleman et al., 2009.8.5, Perkins et al., 2009, Hughes et al., 2008, Ni et al., 2008, Montembault et al., 2010, Cammarato et al., 2011) D14-3-3   d14-3-3zeta (Wu et al., 2005) D14-3-3ζ (Acevedo and Skoulakis, 2001, Kockel et al., 1997) K (Carney et al., 1997) l(2)46CFe   l(2)46Ee   l(2)07103   leo (Mueller et al., 2005, Luschnig et al., 2004, Benton and St. Johnston, 2003, Li and Li, 2003, Sathyanarayana et al., 2003, Benton et al., 2002, Chen et al., 2003, Ahringer, 2003, Jauch et al., 2002, Waddell and Quinn, 2001, Philip et al., 2001, Roman and Davis, 2001, Davis, 2001, Skoulakis and Philip, 2001, Acevedo and Skoulakis, 2001, Li et al., 2000, Prokop, 1999, Casci et al., 1999, Broadie, 1998, Amanai et al., 1998, Skoulakis et al., 1997, Li et al., 1997, Broadie et al., 1997, Chang and Rubin, 1997, Amanai et al., 1997, Wang et al., 2006, Davis, 2004, Acevedo et al., 2007, Yamazaki et al., 2007, Acevedo et al., 2007, McDonald et al., 2008, Messaritou et al., 2010, Messaritou et al., 2009) Leo (Suzuki and Ohno, 2006) LEO (Crittenden et al., 1998) PAR5 (Baas et al., 2004) par-5 (Huynh and St. Johnston, 2004, Pellettieri and Seydoux, 2002) Par-5 (Macara, 2004) PAR-5 (Suzuki and Ohno, 2006) unnamed (Han et al., 1996, Palazzolo et al., 1989, Goldstein et al., 1993)
Name Synonym	14-3-3zeta (Cammarato et al., 2011) 14-3-3ζ (Suzuki and Ohno, 2006, Kaltenbach et al., 2007) Complementation group K (Goldstein et al., 2001, Carney et al., 1997) D14 3 3 protein   leonardo (Janody et al., 2004, Brembs, 2003, Acevedo and Skoulakis, 2002, Johnson Hamlet and Perkins, 2000, Broadie et al., 1997, Skoulakis and Davis, 1996, Skoulakis and Davis, 1996, Davis et al., 2003, Morley and Montgomery, 2001, Waddell and Quinn, 2001, Skoulakis, 1998, Davis, 2004, Yamazaki et al., 2007, Gim et al., 2001, Messaritou et al., 2010, Messaritou et al., 2009) Leonardo (Raabe et al., 2004, McDonald et al., 2008) LEONARDO (Crittenden et al., 1998) Leonardo-13-3-3 (Zars, 2000) leonardo 14-3-3 (Goldstein et al., 2001)
Secondary FlyBase IDs
	FBgn0010635 FBgn0019723 FBgn0023038 FBgn0046306 FBgn0064146
References ( 160 )
Generate a list of	All references relating to this gene ( 160 )
List References by type	Research paper  ( 78 ) Supplementary material  ( 10 ) Review  ( 26 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 25 ) FlyBase analysis  ( 3 ) Letter  ( 2 ) Computer file  ( 3 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 9 )
	Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Przewloka et al., 2011, Curr. Biol. 21(5): 399--405 CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151] Shandala et al., 2011, J. Cell Sci. 124(13): 2165--2174 Drosophila 14-3-3{varepsilon} has a crucial role in anti-microbial peptide secretion and innate immunity. [FBrf0213861] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Karam et al., 2010, PLoS Genet. 6(6): e1000975 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila. [FBrf0210998] Messaritou et al., 2010, J. Biol. Chem. 285(3): 1692--1700 Dimerization is essential for 14-3-3zeta stability and function in vivo. [FBrf0209680] Montembault et al., 2010, J. Cell Biol. 191(7): 1351--1365 Nessun Dorma, a novel centralspindlin partner, is required for cytokinesis in Drosophila spermatocytes. [FBrf0212581] Ren et al., 2010, Dev. Biol. 337(2): 303--312 Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. [FBrf0209792] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...