dHNF4, dHNF-4, HNF4α, NR2A4, NHF4
zinc finger transcription factor - mutants show defects in midgut, Malpighian tubule and salivary gland development - activated by fatty acids released from triglycerides, inducing enzymes that drive fatty acid oxidation for energy production
Gene model reviewed during 5.55
Gene model reviewed during 5.48
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hnf4 using the Feature Mapper tool.
Hnf4 is expressed at high levels in oenocytes, with low levels of expression in the neighboring adult adipose tissue.
Hnf4 protein is expressed in tissues that control metabolic homeostasis. In larvae, Hnf4 is most highly expressed in the midgut and attached gastric caecae, the fat body, the Malpighian tubules, and in oenocytes. Low levels of Hnf4 protein can be detected in the proventriculus and salivary glands. Hnf4 protein is localized to the nucleus.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hnf4 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Hnf4 CG9310
Starved Hnf4 mutant larvae consume glycogen normally but retain lipids in their midgut nd fat body and have increased levels of long-chain fatty acids, suggesting that they are unable to efficiently mobilize stored fat for energy.
Both triglycerides and long chain fatty acids accumulate upon starvation in Hnf4 mutant larvae.
Identified on basis of DNA sequence similarity to rat hepatocyte nuclear factor 4. The analogous expression patterns of the two genes, together with similar findings for rat hepatocyte nuclear factor 3 and fkh, suggest evolutionary relationships between a group of genes involved in gut formation in invertebrates and mammals.