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Gene Dmel\gol

General Information
Symbol	Dmel\gol	Species	D. melanogaster
Name	goliath	Annotation symbol	CG2679
Feature type	protein_coding_gene	FlyBase ID	FBgn0004919
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	g1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60F3-60F3	Sequence location	2R:20,960,150..20,971,843 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene goliath is referred to in FlyBase by the symbol Dmel\gol (CG2679, FBgn0004919). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding. It is reported to be involved in the biological process: regulation of transcription, DNA-dependent; mesoderm development. 8 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Protease-associated domain, PA; Zinc finger, C3HC4 RING-type; Zinc finger, RING-type; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval Malpighian tubules, larval fat body, adult salivary gland. Gene sequence location is 2R:20960150..20971843.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60F3-60F3   Limits computationally determined from genome sequence between P{EP}CG2790EP412&P{EP}CG3776EP835 and P{EP}zipEP856&P{PZ}l(2)1048103263
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60E9-60F11     (Bouchard, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\gol for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) gol-RB FBtr0072459  NM_166705   2556   461 gol-RC FBtr0300178  NM_079140   4116   461 gol-RD FBtr0300179  NM_001169829   2464   601 gol-RE FBtr0306330  NM_001259588   3669   461
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein gol-PB   FBpp0072361   52.6   461   8.06     NP_726508   AAM68328 gol-PC   FBpp0289415   51.8   461   8.61     NP_523864   AAF47316 gol-PD   FBpp0289416   68.6   601   9.00     NP_001163300   ACZ94572 gol-PE   FBpp0297426   51.8   461   8.61     NP_001246517   AFH08270
Additional Polypeptide Data & Comments
Reported size (kDa)	284 (aa); 32 (kD) (Bouchard and Cote, 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Protease-associated domain, PA (IPR003137) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA698133   AE013599 AAF47316   AE013599 AAM68328   AE013599 ACZ94572   AE013599 AFH08270   AI389732   AW940802   AY069169 AAL39314   BI367060   BP542819   BT023710   CA805469   CO185318   CO186990   CO187016   CO190128   CO262064   CO262192   CO263310   CO264605   CO267540   CO269432   CO270547   CO272653   CO272849   CO277097   CO282412   CO289073   CO289919   CO291681   CO293401   CO302828   CO307751   CO312145   CO316482   CO318078   CO325070   CO328204   CO331964   CO339980   CO340631   CO344537   CZ481704   CZ481705   EC061710   EC078376   EC079206   EC080329   EC081736   EC081945   EC082685   EC083295   EC089391   EC194383   EC196589   EC197053   EC199586   EC200501   EC203665   EC209109   EC209956   EC212402   EC212478   EC215556   EC217761   EC218196   EC227277   EC228004   EC230968   EC231070   EC232965   EC235330   EC235478   EC236581   EC242479   EC243765   EC247558   EC257070   EC257480   EC257641   EC260177   M97204 AAA28582
UniProtKB/Swiss-Prot	Q06003
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435926 2R:20,966,587..20,969,610 evidence=Reporter construct (in vivo) (Cunha et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   dorsal pharyngeal muscle primordium   (Fisher et al., 2012) longitudinal visceral muscle primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 14   mesoderm   (Cote et al., 1987) pharyngeal muscle | presumptive   (Cote et al., 1987)
Additional Descriptive Data
	gol transcripts were first detected in the mesoderm of stage 10 embryos, and in the pharyngeal muscle anlagen. Expression was not detected past stage 14. (Cote et al., 1987)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval midgut, larval Malpighian tubules, larval fat body, adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male    41 head, mated 4-day male    53 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female  (28) head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male  (41) head, mated 4-day male  (53) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male    41 head, mated 4-day male    53 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male    41 head, mated 4-day male    53 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male    41 head, mated 4-day male    53 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female  28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male  (41) head, mated 4-day male  (53) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male    41 head, mated 4-day male    53 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    18 head, virgin 1-day female    15 head, virgin 4-day female    20 head, virgin 20-day female    17 head, mated 1-day female    28 head, mated 4-day female    23 head, mated 20-day female    10 head, mated 1-day male    41 head, mated 4-day male    53 head, mated 20-day male    34 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    2 digestive system, 4-day adult    2 digestive system, 20-day adult    2 fat body, larvae L3 wandering    4 fat body, white prepupae    3 fat body, pupae P8    8 carcass, larvae L3 wandering    2 carcass, 1-day adult    2 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    9 embryo 10-12hr    9 embryo 12-14hr    10 embryo 14-16hr    5 embryo 16-18hr    7 embryo 18-20hr    7 embryo 20-22hr    7 embryo 22-24hr    9 larva L1    4 larva L2    1 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    11 white prepupae 24hr    9 pupae 2d postWPP    8 pupae 3d postWPP    6 pupae 4d postWPP    8 adult male 01day    12 adult male 05day    9 adult male 30day    8 adult female 01day    5 adult female 05day    2 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    9 embryonic 1182-4H    1 embryonic GM2    5 embryonic Kc167    4 embryonic S1    0 embryonic S3    0 leg disc CME L1    21 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    1 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    2 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    8 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    4 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    1 Copper 15 mM 48 hrs, 4-day adult    11 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    5 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_24 mE1_20_mRNA_expression_cluster_14
External Data & Images
Linkouts	BDGP expression data • GH20973 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004919 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2679-RA;CG2679-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for gol Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 golGD3528 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of gol Class Mutagen Stocks Known lesion gole03943 piggyBac transposase 1 -- golf06272 1 -- golMB03006 1 -- golMI04636 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of gol Class Mutagen Stocks Known lesion golGD3528 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes golJF03213 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes golKK108421 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes golNIG.2679R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)ES1 (Cote et al., 1987) Df(2R)gsb (Cote et al., 1987, Duman-Scheel et al., 1997) Df(2R)Kr10 (Cote et al., 1987, Duman-Scheel et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3528} NA P{KK108421} NA P{NIG.2679R} NA P{TRiP.JF03213} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP2599EP2599 NA miscellaneous insertions Mi{MIC}golMI04636 NA PBac{RB}gole03943 NA PBac{WH}golf06272 NA insertion of enhancer trap binary system Mi{ET1}golMB03006 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mesoderm development non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) regulation of transcription, DNA-dependent non-traceable author statement (Swiss-Prot Project Members, 1994.2.1)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1994.2.1) non-traceable author statement (assigned by UniProtKB) (Bouchard and Cote, 1993)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions gol allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0004919 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38006
Orthologs
OrthoDB Orthologs (24) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6M39V4 Dipteran inclusive ortholog search EOG6R7VK0 Insect inclusive ortholog search EOG6HT7NX Arthropod inclusive ortholog search EOG6J6Q6J Metazoa inclusive ortholog search EOG6TTVBV
Orthologs in Drosophila Species (EOG6M39V4)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\gol     Drosophila simulans   Dsim\GD24897 Y   Drosophila sechellia   Dsec\GM11764 Y   Drosophila erecta   Dere\GG19861 Y   Drosophila yakuba   Dyak\GE11386 Y   Drosophila ananassae   Dana\GF11510 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15425 Y   Drosophila persimilis   Dper\GL16830 Y   Drosophila willistoni   Dwil\GK21726 Y   Drosophila virilis   Dvir\GJ21338 Y   Drosophila mojavensis   Dmoj\GI18477 Y   Drosophila grimshawi   Dgri\GH23135 Y
Orthologs in non-Drosophila Dipterans (EOG6R7VK0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012337   Anopheles gambiae Malaria mosquito  Agam\AGAP010356   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006498   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006497
Orthologs in non-Dipteran Insects (EOG6HT7NX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI009067   Bombyx mori Silkmoth  Bmor\BGIBMGA009253   Pediculus humanus Human body louse  Phum\PHUM457790   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07101
Orthologs in non-Insect Arthropods (EOG6J6Q6J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb   Ixodes scapularis Deer tick  Isca\ISCW003743
Orthologs in non-Arthropod Metazoa (EOG6TTVBV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\H10E21.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001450gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24897 Drosophila sechellia Dsec\GM11764 Drosophila erecta Dere\GG19861 Drosophila yakuba Dyak\GE11386 Drosophila ananassae Dana\GF11510 Drosophila pseudoobscura pseudoobscura Dpse\GA15425 Drosophila persimilis Dper\GL16830 Drosophila willistoni Dwil\GK21726 Drosophila virilis Dvir\GJ21338 Drosophila mojavensis Dmoj\GI18477 Drosophila grimshawi Dgri\GH23135
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	23834 w1118; Mi{ET1}golMB03006 28785 y1 v1; P{TRiP.JF03213}attP2 40204 y1 w*; Mi{MIC}golMI04636
Harvard	- PBac{RB}gole03943 - PBac{WH}golf06272
VDRC	v107822 P{KK108421}VIE-260B v37435 w1118; P{GD3528}v37435 v37434 w1118; P{GD3528}v37434/TM3
Genomic Clones ( 1 )
	BACR17E16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20973 HL03823
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE52734
Other clones	1632 8930 9314 16791 30604 38256 44866 61620 67256 70588 71120 72202 79565 98918 149747 161146 165675 173614 194530 214225.65 214371.84 214415.63 214543.5 274475 CK01.3B.C8 CK01.26B.G8 CK01.26C.C4 CK01.53C.E7 CK01.89A.A6 CK01.92D.H1 CK01.98D.F8 CK01.99C.D5 CK01.100A.H5 CK01.124B.F1 EK008031 EK025143 EK025332 EK046708 EK070035 EK072529 EK084315 EK084624 EK088203 EK094521 EK099306 EK107941 EK108541 EK122937 EK139712 EK150749 EK160421 EK184958 EK195520 EK197953 EK202836 EK227942 EK255457 EK265048 EK270259 EK302151 EP08740 EP09817 EP11030 EP19449 ESG0118b.B21_D12 FGC017B06
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004919 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38006
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: gol CG2679 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	This gooseberry-region gene cloned by Cote et al. (EMBO J. 6(9): 2793--2802) encodes a Zn finger protein expressed in the mesoderm. (Bouchard and Cote, 1993) gol gene expression is widespread in embryonic differentiating mesoderm, followed by a gradual shift to neural derivatives during late germband retraction. (Bouchard and Cote, 1992) Genomic organization of the gol transcription unit and spatial expression pattern has been determined. The gol coding sequence exhibits significant homology to regions of a human growth hormone coding gene. (Bouchard and Cote, 1991) Included in genetic and molecular analysis of the zipper-gooseberry region. (Cote et al., 1987) Genomic organization of the gol transcription unit and spatial expression pattern has been determined.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079140 NM_166705 NM_001169829 NM_001259588 RefSeq (Proteins) • NP_523864 NP_726508 NP_001163300 NP_001246517 DDBJ / EMBL / GenBank • AA698133 AAA28582 AAF47316 AAL39314 AAM68328 ACZ94572 AFH08270 AI389732 AW940802 AY069169 CZ481704 CZ481705 M97204 Entrez Gene - A searchable database of RefSeq genes. • 38006 UniProtKB/Swiss-Prot • Q06003
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, RING-type (IPR001841) Protease-associated domain, PA (IPR003137) Zinc finger, C3HC4 RING-type (IPR018957) Zinc finger, RING/FYVE/PHD-type (IPR013083) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH20973
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0004919 DRSC - Results from RNAi screens. • FBgn0004919 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004919 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2679-RA;CG2679-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004919 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38006 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38006 modMine - Data generated by the modENCODE project. • FBgn0004919
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-G1   CG2679 (Goldman and Arbeitman, 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ying et al., 2011) g1 (Duman-Scheel et al., 1997, Bouchard and Cote, 1991, Bouchard and Cote, 1993, Cote et al., 1987, ) gol (Mudiganti et al., 2010, Jungreis, 2011.11.18, Abruzzi et al., 2011, Choksi et al., 2006, Junion et al., 2007, Weake et al., 2011, Zeitlinger et al., 2007, Cunha et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Senthilan et al., 2012, Manning et al., 2012) Gol (Miller et al., 2010) meso
Name Synonym	goliath (Bouchard, 1992, Hoopfer et al., 2008, Goldman and Arbeitman, 2007) Goliath (Ying et al., 2011)
Secondary FlyBase IDs
	FBgn0004375 FBgn0004899
References ( 47 )
Generate a list of	All references relating to this gene ( 47 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 6 )
	Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Ying et al., 2011, PLoS ONE 6(9): e23863 Comprehensively Surveying Structure and Function of RING Domains from Drosophila melanogaster. [FBrf0215242] Show all research papers ...