FB2021_03, released June 15, 2021

Gene: Dmel\gol

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General Information
Symbol
Dmel\gol
Species
D. melanogaster
Name
goliath
Annotation Symbol
CG2679
Feature Type
protein_coding_gene
FlyBase ID
FBgn0004919
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
goliath (gol) encodes an E3 ubiquitin ligase, whose cellular substrates are unknown. During embyrogenesis gol is expressed in fusion-competence myoblasts of the somatic and visceral mesoderm. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

g1

Key Links
Genomic Location
Cytogenetic map
60F3-60F3
Sequence location
2R:25,072,627..25,084,347 [-]
Recombination map
2-107
RefSeq locus
NT_033778 REGION:25072627..25084347
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ubiquitin protein ligase activity
inferred from sequence or structural similarity with FLYBASE:gzl; FB:FBgn0037442
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN001864905
(assigned by GO_Central )
(Gaudet et al., 2011)
enables zinc ion binding
inferred from sequence model
(Ying et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in mesoderm formation
inferred from expression pattern
(assigned by UniProt )
(Bouchard and Cote, 1993)
involved_in protein ubiquitination
inferred from mutant phenotype
(Yamazaki et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN001864905
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Yamazaki et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN004565028
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
non-traceable author statement
(assigned by UniProt )
(Bouchard and Cote, 1993)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
goliath (gol) encodes an E3 ubiquitin ligase, whose cellular substrates are unknown. During embyrogenesis gol is expressed in fusion-competence myoblasts of the somatic and visceral mesoderm. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
GOLIATH UBIQUITIN LIGASES -
E3 (ubiquitin) ligases interact with both ubiquitin-E2 (ubiquitin-conjugating) enzymes and the target protein, transferring the ubiquitin from the E2 to the substrate. The Goliath (or GRAIL) E3 ligases possess transmembrane spanning domain, a protease-associated domain and a RING finger domain. (Adapted from FBrf0220873).
Protein Function (UniProtKB)
Regulation of gene expression during embryonic mesoderm formation. Putative role as transcription factor.
(UniProt, Q06003)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\gol for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
gol-RB
FBtr0072459
NM_166705
2583
461
gol-RC
FBtr0300178
NM_079140
3193
461
gol-RD
FBtr0300179
NM_001169829
2520
601
gol-RE
FBtr0306330
NM_001259588
3725
461
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
gol-PB
FBpp0072361
52.6
461
8.06
NP_726508
AAM68328
gol-PC
FBpp0289415
51.8
461
8.61
NP_523864
AAF47316
gol-PD
FBpp0289416
68.6
601
9.00
NP_001163300
ACZ94572
gol-PE
FBpp0297426
51.8
461
8.61
NP_001246517
AFH08270
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

461 aa isoforms: gol-PC, gol-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

284 (aa); 32 (kD)

(Bouchard and Cote, 1993)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gol using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
mesoderm
(Cunha et al., 2010)
embryonic stage 11 -- 12
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
longitudinal visceral muscle primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 14
mesoderm
(Cote et al., 1987)
pharyngeal muscle | presumptive
(Cote et al., 1987)
Additional Descriptive Data

gol transcripts were first detected in the mesoderm of stage 10 embryos, and in the pharyngeal muscle anlagen. Expression was not detected past stage 14.

(Cote et al., 1987)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endosome
inferred from direct assay
(Yamazaki et al., 2013)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\gol in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of gol
Transgenic constructs containing regulatory region of gol
Aberrations (Deficiencies and Duplications) ( 4 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\RNF150
12 of 15
Yes
Yes
1  
Hsap\RNF130
9 of 15
No
Yes
Hsap\RNF149
7 of 15
No
Yes
Hsap\RNF128
6 of 15
No
Yes
Hsap\RNF133
4 of 15
No
Yes
Hsap\RNF148
4 of 15
No
Yes
Hsap\RLIM
2 of 15
No
No
1  
Hsap\RNF6
2 of 15
No
No
Hsap\RNF13
2 of 15
No
No
1  
Hsap\RNF103
2 of 15
No
Yes
Hsap\RNF167
2 of 15
No
No
Hsap\RNF215
2 of 15
No
Yes
Hsap\ZNRF3
2 of 15
No
No
Hsap\CHMP3
1 of 15
No
No
1  
Hsap\DZIP3
1 of 15
No
Yes
Hsap\KRT14
1 of 15
No
Yes
3  
Hsap\PJA1
1 of 15
No
No
Hsap\PJA2
1 of 15
No
No
Hsap\RNF11
1 of 15
No
No
Hsap\RNF24
1 of 15
No
No
Hsap\RNF32
1 of 15
No
Yes
Hsap\RNF38
1 of 15
No
No
Hsap\RNF43
1 of 15
No
Yes
Hsap\RNF44
1 of 15
No
No
Hsap\RNF103-CHMP3
1 of 15
No
No
Hsap\RNF111
1 of 15
No
No
Hsap\RNF115
1 of 15
No
No
Hsap\RNF122
1 of 15
No
No
Hsap\RNF126
1 of 15
No
No
Hsap\RNF165
1 of 15
No
No
Hsap\RNF181
1 of 15
No
No
Hsap\TTC3
1 of 15
No
No
Hsap\ZSWIM2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (32)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Rnf150
12 of 15
Yes
Yes
Mmus\Rnf130
9 of 15
No
Yes
Mmus\Rnf149
6 of 15
No
Yes
Mmus\Rnf128
5 of 15
No
Yes
Mmus\Rnf133
4 of 15
No
Yes
Mmus\Rnf148
3 of 15
No
Yes
Mmus\Rnf215
3 of 15
No
Yes
Mmus\4930595M18Rik
2 of 15
No
No
Mmus\Rlim
2 of 15
No
No
Mmus\Rnf6
2 of 15
No
No
Mmus\Rnf13
2 of 15
No
No
Mmus\Rnf43
2 of 15
No
Yes
Mmus\Rnf103
2 of 15
No
Yes
Mmus\Rnf167
2 of 15
No
No
Mmus\Znrf3
2 of 15
No
No
Mmus\Dzip3
1 of 15
No
Yes
Mmus\Pja1
1 of 15
No
No
Mmus\Pja2
1 of 15
No
No
Mmus\Rnf11
1 of 15
No
No
Mmus\Rnf24
1 of 15
No
No
Mmus\Rnf32
1 of 15
No
Yes
Mmus\Rnf38
1 of 15
No
No
Mmus\Rnf44
1 of 15
No
No
Mmus\Rnf111
1 of 15
No
No
Mmus\Rnf115
1 of 15
No
No
Mmus\Rnf122
1 of 15
No
No
Mmus\Rnf126
1 of 15
No
No
Mmus\Rnf165
1 of 15
No
No
Mmus\Rnf181
1 of 15
No
No
Mmus\Ttc3
1 of 15
No
No
Mmus\Znrf4
1 of 15
No
No
Mmus\Zswim2
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (30)
Rnor\Rnf150
10 of 13
Yes
Yes
Rnor\Rnf149
7 of 13
No
Yes
Rnor\Rnf130
6 of 13
No
Yes
Rnor\Rnf128
5 of 13
No
Yes
Rnor\Rnf148
4 of 13
No
Yes
Rnor\Rnf133
3 of 13
No
Yes
Rnor\Rnf215
3 of 13
No
Yes
Rnor\Rnf6
2 of 13
No
No
Rnor\Rnf13
2 of 13
No
No
Rnor\Rnf43
2 of 13
No
Yes
Rnor\Rnf167
2 of 13
No
No
Rnor\Dzip3
1 of 13
No
Yes
Rnor\LOC100910646
1 of 13
No
Yes
Rnor\Pja1
1 of 13
No
No
Rnor\Pja2
1 of 13
No
No
Rnor\Rlim
1 of 13
No
No
Rnor\Rlim
1 of 13
No
Yes
Rnor\Rnf32
1 of 13
No
Yes
Rnor\Rnf38
1 of 13
No
No
Rnor\Rnf44
1 of 13
No
No
Rnor\Rnf103
1 of 13
No
Yes
Rnor\Rnf115
1 of 13
No
No
Rnor\Rnf122
1 of 13
No
No
Rnor\Rnf126
1 of 13
No
No
Rnor\Rnf165
1 of 13
No
No
Rnor\Rnf181
1 of 13
No
No
Rnor\Srsf8
1 of 13
No
Yes
Rnor\Ttc3
1 of 13
No
Yes
Rnor\Znrf3
1 of 13
No
Yes
Rnor\Znrf4
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (21)
Xtro\rnf149
7 of 12
Yes
Yes
Xtro\rnf150
6 of 12
No
Yes
Xtro\chmp3
2 of 12
No
No
Xtro\rlim
2 of 12
No
No
Xtro\rnf44
2 of 12
No
No
Xtro\rnf130
2 of 12
No
Yes
Xtro\znrf3
2 of 12
No
No
Xtro\pja2
1 of 12
No
No
Xtro\rnf11.2
1 of 12
No
No
Xtro\rnf11
1 of 12
No
No
Xtro\rnf13
1 of 12
No
No
Xtro\rnf24
1 of 12
No
No
Xtro\rnf32
1 of 12
No
Yes
Xtro\rnf38
1 of 12
No
No
Xtro\rnf43
1 of 12
No
Yes
Xtro\rnf111
1 of 12
No
No
Xtro\rnf115
1 of 12
No
No
Xtro\rnf126
1 of 12
No
No
Xtro\rnf128
1 of 12
No
Yes
Xtro\rnf167
1 of 12
No
No
Xtro\rnf181
1 of 12
No
No
Danio rerio (Zebrafish) (29)
Drer\rnf150a
11 of 15
Yes
Yes
Drer\rnf150b
11 of 15
Yes
Yes
Drer\rnf130
6 of 15
No
Yes
Drer\rnf128a
4 of 15
No
Yes
Drer\LOC100536511
3 of 15
No
Yes
Drer\rlim
2 of 15
No
No
Drer\rnf6
2 of 15
No
No
Drer\rnf13
2 of 15
No
No
Drer\rnf103
2 of 15
No
Yes
Drer\rnf167
2 of 15
No
No
Drer\rnf181
2 of 15
No
No
Drer\rnf215
2 of 15
No
Yes
Drer\znrf3
2 of 15
No
No
Drer\rnf11a
1 of 15
No
No
Drer\rnf11b
1 of 15
No
No
Drer\rnf24
1 of 15
No
No
Drer\rnf32
1 of 15
No
Yes
Drer\rnf38
1 of 15
No
No
Drer\rnf44
1 of 15
No
No
Drer\rnf111
1 of 15
No
No
Drer\rnf115
1 of 15
No
No
Drer\rnf126
1 of 15
No
No
Drer\rnf165b
1 of 15
No
No
Drer\si:ch211-59o9.10
1 of 15
No
Yes
Drer\si:ch211-81a5.1
1 of 15
No
No
Drer\si:ch1073-392o20.1
1 of 15
No
No
Drer\si:dkey-51a16.9
1 of 15
No
No
Drer\zgc:175214
1 of 15
No
No
Drer\zswim2
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (9)
Cele\H10E21.5
9 of 15
Yes
Yes
Cele\plr-1
2 of 15
No
No
Cele\C01G6.4
1 of 15
No
No
Cele\C32D5.10
1 of 15
No
No
Cele\C32D5.11
1 of 15
No
No
Cele\toe-4
1 of 15
No
No
Cele\Y54E10BR.3
1 of 15
No
No
Cele\Y105C5B.11
1 of 15
No
Yes
Cele\ZK637.14
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (19)
Atha\AT1G22670
3 of 9
Yes
No
Atha\AT1G35625
3 of 9
Yes
No
Atha\AT1G35630
3 of 9
Yes
No
Atha\AT1G71980
3 of 9
Yes
No
Atha\AT4G09560
3 of 9
Yes
No
Atha\RMR1
3 of 9
Yes
No
Atha\AT1G35330
1 of 9
No
Yes
Atha\AT1G57730
1 of 9
No
Yes
Atha\AT2G46493
1 of 9
No
Yes
Atha\AT3G28620
1 of 9
No
Yes
Atha\AT3G48030
1 of 9
No
No
Atha\AT4G09100
1 of 9
No
Yes
Atha\AT4G09110
1 of 9
No
Yes
Atha\AT5G41430
1 of 9
No
Yes
Atha\AT5G41450
1 of 9
No
Yes
Atha\AT5G43200
1 of 9
No
Yes
Atha\AT5G45290
1 of 9
No
Yes
Atha\AT5G52155
1 of 9
No
Yes
Atha\RING1
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ASR1
1 of 15
Yes
Yes
Scer\HRD1
1 of 15
Yes
No
Scer\YBR062C
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC57A7.09
2 of 12
Yes
No
Spom\meu34
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905SY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003620
Drosophila simulans
Dsim\GD24897
Drosophila sechellia
Dsec\GM11764
Drosophila erecta
Dere\GG19861
Drosophila yakuba
Dyak\GE11386
Drosophila ananassae
Dana\GF11510
Drosophila pseudoobscura pseudoobscura
Dpse\GA15425
Drosophila persimilis
Dper\GL16830
Drosophila willistoni
Dwil\GK21726
Drosophila virilis
Dvir\GJ21338
Drosophila mojavensis
Dmoj\GI18477
Drosophila grimshawi
Dgri\GH23135
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915070Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013957
Glossina morsitans
Tsetse fly
Gmor\GMOY006452
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02910
Mayetiola destructor
Hessian fly
Mdes\Mdes011466
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012337
Anopheles darlingi
American malaria mosquito
Adar\ADAC003537
Anopheles gambiae
Malaria mosquito
Agam\AGAP010356
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006498
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006497
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W078P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009253
Danaus plexippus
Monarch butterfly
Dple\DPOGS216100-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007866
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07532
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07101
Pediculus humanus
Human body louse
Phum\PHUM457790
Cimex lectularius
Bed bug
Clec\CLEC011333
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009067
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06703
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X073Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW003743
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78329.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur24g00580
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327936
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09RT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000011573
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (9)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG6923
3 of 10
gzl
3 of 10
mura
2 of 10
CG4325
1 of 10
CG7694
1 of 10
CG10916
1 of 10
Iru
1 of 10
Rnf11
1 of 10
sip3
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    golGD3528
    ameliorates  Huntington's disease
    modeled by Hsap\HTT128Q.1-336.UAS
    (Miller et al., 2010)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    RNF150; ring finger protein 150
    12 of 15
         
        RNF130; ring finger protein 130
        9 of 15
        619163
            RNF149; ring finger protein 149
            7 of 15
                RNF128; ring finger protein 128
                6 of 15
                300439
                    RNF133; ring finger protein 133
                    4 of 15
                        RNF148; ring finger protein 148
                        4 of 15
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            esyN Network Diagram
                            Interactions Browser
                            Summary of Genetic Interactions
                            esyN Network Diagram
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            External Data
                            Linkouts
                            DroID - A comprehensive database of gene and protein interactions.
                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            External Data
                            Linkouts
                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            2R
                            Recombination map
                            2-107
                            Cytogenetic map
                            60F3-60F3
                            Sequence location
                            2R:25,072,627..25,084,347 [-]
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            60F3-60F3
                            Limits computationally determined from genome sequence between P{EP}CG2790EP412&P{EP}CG3776EP835 and P{EP}zipEP856&P{PZ}l(2)1048103263
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            60E9-60F11
                            (Bouchard, 1992)
                            Experimentally Determined Recombination Data
                            Location

                            2-107

                            (FlyBase, 2016)

                            2-111.8

                            (Comeron et al., 2012)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (9)
                            Genomic Clones (13)
                             

                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                            cDNA Clones (60)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                            Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of

                              Source for identity of: gol CG2679

                              (Zhong, 1999.11)
                              Source for database merge of
                              Additional comments
                              Other Comments

                              gol gene expression is widespread in embryonic differentiating mesoderm, followed by a gradual shift to neural derivatives during late germband retraction.

                              (Bouchard and Cote, 1992)

                              Genomic organization of the gol transcription unit and spatial expression pattern has been determined. The gol coding sequence exhibits significant homology to regions of a human growth hormone coding gene.

                              (Bouchard and Cote, 1991)

                              Included in genetic and molecular analysis of the zipper-gooseberry region.

                              (Cote et al., 1987)
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 48 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              DRscDB
                              EMBL-EBI Single Cell Expression Atlas
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              MARRVEL_MODEL
                              modMine - A data warehouse for the modENCODE project
                              Linkouts
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Synonyms and Secondary IDs (9)
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (66)