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Gene Dmel\eIF-2β

General Information
Symbol	Dmel\eIF-2β	Species	D. melanogaster
Name	Eukaryotic initiation factor 2β	Annotation symbol	CG4153
Feature type	protein_coding_gene	FlyBase ID	FBgn0004926
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	eIF-2beta, eIF2β, elF2β, eIF-2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69C4-69C4	Sequence location	3L:12,518,193..12,519,837 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Eukaryotic initiation factor 2β is referred to in FlyBase by the symbol Dmel\eIF-2β (CG4153, FBgn0004926). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization; axon midline choice point recognition. 12 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Translation initiation factor IF2/IF5; Translation initiation factor IF2/IF5, N-terminal; Translation initiation factor IF2/IF5, zinc-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1636176_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eIF-2beta. Gene sequence location is 3L:12518193..12519837.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA11341 BKN28791
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69C4-69C4   Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF-2β for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF-2β-RA FBtr0075968  NM_079319   1134   312
Additional Transcript Data & Comments
Reported size (kB)	1.2 (northern blot) (Ye and Cavener, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF-2β-PA   FBpp0075700   35.2   312   5.42     NP_524043   AAF49902
Additional Polypeptide Data & Comments
Reported size (kDa)	312 (aa) (Ye and Cavener, 1994)
Comments	The amino acid sequence of Eif2β shows a C2-C2 nucleic acid binding motif in the C-terminal region. (Ye and Cavener, 1994)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Translation initiation factor IF2/IF5 (IPR002735) Translation initiation factor IF2/IF5, N-terminal (IPR016189) Translation initiation factor IF2/IF5, zinc-binding (IPR016190)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567047   AA736129   AE014296 AAF49902   AI062963   AI063893   AI108692   AI134075   AI134681   AI260013   AI295150   AI296062   AI297470   AI402406   AI405480   AI456533   AI531586   AI543148   AI543848   AI946908   AQ254621   AY071253 AAL48875   BE975302   BE976627   BI170917   BI231959   BI232045   BI233005   BI241632   BI354779   BI364662   BI370234   BI569724   BI606680   BI622996   BI637019   BI637062   BI637114   BI637133   BP546884   BP547667   BP549284   BT126273   BX007413   BX008881   BX011762   BX011963   BX013107   BX014541   BX015004   BX016918   BX026639   BX026711   BX028731   BX030486   BX032001   BX035429   BX043482   BX049700   BX055762   BX057920   BX060636   BX061117   BX065024   CL525980   CO191805   CO303124   CO303635   CO307067   CO316277   CO322619   CO330716   CZ470350   EC065592   EC077931   EC088087   EC211919   EC225988   EC238017   EC250835   EC266200   EL877812   EL877933   EV575652   EV575760   EV580483   EV580691   EV583509   EV587335   EV587442   EV587732   EV589057   EV590660   GH747769   GH748914   GH752889   GH757351   GH759969   GH774046   GH780684   GH784406   GH785310   GH792570   GH793322   GH793445   GH796559   GH798150   GH799526   GH802624   GH809170   GH812817   GH816053   GH820231   GH821314   GH822440   GH826201   GH832659   GH834948   GH852254   GH853238   GH853569   GH853665   GH854012   GH854431   GH855578   GH856668   GH861174   GH862485   GH865193   GH869768   GH872305   GH877773   GH879838   GH881949   GH889017   GH892703   GH895596   GH896681   GH905918   GH912790   GH913906   GH916479   GH919447   GH921570   GH921696   GH926068   GH928687   GH931914   GH934899   GH938557   L19197 AAA28504
UniProtKB/Swiss-Prot	P41375
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Ye and Cavener, 1994)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004926    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004926 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed within 00-18 hour embryonic stages, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004926 expression level Developmental Stage   Expression Level embryo 00-02hr    12311 embryo 02-04hr    5781 embryo 04-06hr    13526 embryo 06-08hr    13739 embryo 08-10hr    12254 embryo 10-12hr    14144 embryo 12-14hr    10923 embryo 14-16hr    10181 embryo 16-18hr    9113 embryo 18-20hr    6238 embryo 20-22hr    7233 embryo 22-24hr    6409 larva L1    17380 larva L2    16931 larva L3 12hr old    12750 larva L3 puffstage 1-2    7927 larva L3 puffstage 3-6    8105 larva L3 puffstage 7-9    9372 white prepupae new    8958 white prepupae 12hr    7359 white prepupae 24hr    9112 pupae 2d postWPP    8492 pupae 3d postWPP    6689 pupae 4d postWPP    5180 adult male 01day    6121 adult male 05day    6635 adult male 30day    7155 adult female 01day    11936 adult female 05day    15482 adult female 30day    16726 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12311) embryo 02-04hr  (5781) embryo 04-06hr  (13526) embryo 06-08hr  (13739) embryo 08-10hr  (12254) embryo 10-12hr  (14144) embryo 12-14hr  (10923) embryo 14-16hr  (10181) embryo 16-18hr  (9113) embryo 18-20hr  (6238) embryo 20-22hr  (7233) embryo 22-24hr  (6409) larva L1  (17380) larva L2  (16931) larva L3 12hr old  (12750) larva L3 puffstage 1-2  (7927) larva L3 puffstage 3-6  (8105) larva L3 puffstage 7-9  (9372) white prepupae new  (8958) white prepupae 12hr  (7359) white prepupae 24hr  (9112) pupae 2d postWPP  (8492) pupae 3d postWPP  (6689) pupae 4d postWPP  (5180) adult male 01day  (6121) adult male 05day  (6635) adult male 30day  (7155) adult female 01day  (11936) adult female 05day  (15482) adult female 30day  (16726) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12311) embryo 02-04hr  (5781) embryo 04-06hr  (13526) embryo 06-08hr  (13739) embryo 08-10hr  (12254) embryo 10-12hr  (14144) embryo 12-14hr  (10923) embryo 14-16hr  (10181) embryo 16-18hr  (9113) embryo 18-20hr  (6238) embryo 20-22hr  (7233) embryo 22-24hr  (6409) larva L1  (17380) larva L2  (16931) larva L3 12hr old  (12750) larva L3 puffstage 1-2  (7927) larva L3 puffstage 3-6  (8105) larva L3 puffstage 7-9  (9372) white prepupae new  (8958) white prepupae 12hr  (7359) white prepupae 24hr  (9112) pupae 2d postWPP  (8492) pupae 3d postWPP  (6689) pupae 4d postWPP  (5180) adult male 01day  (6121) adult male 05day  (6635) adult male 30day  (7155) adult female 01day  (11936) adult female 05day  (15482) adult female 30day  (16726) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (12311) embryo 02-04hr    5781 embryo 04-06hr  (13526) embryo 06-08hr  (13739) embryo 08-10hr  (12254) embryo 10-12hr  (14144) embryo 12-14hr  (10923) embryo 14-16hr  10181 embryo 16-18hr    9113 embryo 18-20hr    6238 embryo 20-22hr    7233 embryo 22-24hr    6409 larva L1  (17380) larva L2  (16931) larva L3 12hr old  (12750) larva L3 puffstage 1-2    7927 larva L3 puffstage 3-6    8105 larva L3 puffstage 7-9    9372 white prepupae new    8958 white prepupae 12hr    7359 white prepupae 24hr    9112 pupae 2d postWPP    8492 pupae 3d postWPP    6689 pupae 4d postWPP    5180 adult male 01day    6121 adult male 05day    6635 adult male 30day    7155 adult female 01day  (11936) adult female 05day  (15482) adult female 30day  (16726) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12311 embryo 02-04hr    5781 embryo 04-06hr    13526 embryo 06-08hr    13739 embryo 08-10hr    12254 embryo 10-12hr    14144 embryo 12-14hr    10923 embryo 14-16hr    10181 embryo 16-18hr    9113 embryo 18-20hr    6238 embryo 20-22hr    7233 embryo 22-24hr    6409 larva L1    17380 larva L2    16931 larva L3 12hr old    12750 larva L3 puffstage 1-2    7927 larva L3 puffstage 3-6    8105 larva L3 puffstage 7-9    9372 white prepupae new    8958 white prepupae 12hr    7359 white prepupae 24hr    9112 pupae 2d postWPP    8492 pupae 3d postWPP    6689 pupae 4d postWPP    5180 adult male 01day    6121 adult male 05day    6635 adult male 30day    7155 adult female 01day    11936 adult female 05day    15482 adult female 30day    16726 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004926 expression level Developmental Stage   Expression Level embryo 00-02hr    12311 embryo 02-04hr    5781 embryo 04-06hr    13526 embryo 06-08hr    13739 embryo 08-10hr    12254 embryo 10-12hr    14144 embryo 12-14hr    10923 embryo 14-16hr    10181 embryo 16-18hr    9113 embryo 18-20hr    6238 embryo 20-22hr    7233 embryo 22-24hr    6409 larva L1    17380 larva L2    16931 larva L3 12hr old    12750 larva L3 puffstage 1-2    7927 larva L3 puffstage 3-6    8105 larva L3 puffstage 7-9    9372 white prepupae new    8958 white prepupae 12hr    7359 white prepupae 24hr    9112 pupae 2d postWPP    8492 pupae 3d postWPP    6689 pupae 4d postWPP    5180 adult male 01day    6121 adult male 05day    6635 adult male 30day    7155 adult female 01day    11936 adult female 05day    15482 adult female 30day    16726 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (12311) embryo 02-04hr  (5781) embryo 04-06hr  (13526) embryo 06-08hr  (13739) embryo 08-10hr  (12254) embryo 10-12hr  (14144) embryo 12-14hr  (10923) embryo 14-16hr  (10181) embryo 16-18hr  (9113) embryo 18-20hr  (6238) embryo 20-22hr  (7233) embryo 22-24hr  (6409) larva L1  (17380) larva L2  (16931) larva L3 12hr old  (12750) larva L3 puffstage 1-2  (7927) larva L3 puffstage 3-6  (8105) larva L3 puffstage 7-9  (9372) white prepupae new  (8958) white prepupae 12hr  (7359) white prepupae 24hr  (9112) pupae 2d postWPP  (8492) pupae 3d postWPP  (6689) pupae 4d postWPP  (5180) adult male 01day  (6121) adult male 05day  (6635) adult male 30day  (7155) adult female 01day  (11936) adult female 05day  (15482) adult female 30day  (16726) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (12311) embryo 02-04hr  (5781) embryo 04-06hr  (13526) embryo 06-08hr  (13739) embryo 08-10hr  (12254) embryo 10-12hr  (14144) embryo 12-14hr  (10923) embryo 14-16hr  (10181) embryo 16-18hr  (9113) embryo 18-20hr  (6238) embryo 20-22hr  (7233) embryo 22-24hr  (6409) larva L1  (17380) larva L2  (16931) larva L3 12hr old  (12750) larva L3 puffstage 1-2  (7927) larva L3 puffstage 3-6  (8105) larva L3 puffstage 7-9  (9372) white prepupae new  (8958) white prepupae 12hr  (7359) white prepupae 24hr  (9112) pupae 2d postWPP  (8492) pupae 3d postWPP  (6689) pupae 4d postWPP  (5180) adult male 01day  (6121) adult male 05day  (6635) adult male 30day  (7155) adult female 01day  (11936) adult female 05day  (15482) adult female 30day  (16726) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  12311 embryo 02-04hr    5781 embryo 04-06hr  13526 embryo 06-08hr  13739 embryo 08-10hr  12254 embryo 10-12hr  14144 embryo 12-14hr  10923 embryo 14-16hr  10181 embryo 16-18hr    9113 embryo 18-20hr    6238 embryo 20-22hr    7233 embryo 22-24hr    6409 larva L1  17380 larva L2  16931 larva L3 12hr old  12750 larva L3 puffstage 1-2    7927 larva L3 puffstage 3-6    8105 larva L3 puffstage 7-9    9372 white prepupae new    8958 white prepupae 12hr    7359 white prepupae 24hr    9112 pupae 2d postWPP    8492 pupae 3d postWPP    6689 pupae 4d postWPP    5180 adult male 01day    6121 adult male 05day    6635 adult male 30day    7155 adult female 01day  11936 adult female 05day  15482 adult female 30day  16726 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    12311 embryo 02-04hr    5781 embryo 04-06hr    13526 embryo 06-08hr    13739 embryo 08-10hr    12254 embryo 10-12hr    14144 embryo 12-14hr    10923 embryo 14-16hr    10181 embryo 16-18hr    9113 embryo 18-20hr    6238 embryo 20-22hr    7233 embryo 22-24hr    6409 larva L1    17380 larva L2    16931 larva L3 12hr old    12750 larva L3 puffstage 1-2    7927 larva L3 puffstage 3-6    8105 larva L3 puffstage 7-9    9372 white prepupae new    8958 white prepupae 12hr    7359 white prepupae 24hr    9112 pupae 2d postWPP    8492 pupae 3d postWPP    6689 pupae 4d postWPP    5180 adult male 01day    6121 adult male 05day    6635 adult male 30day    7155 adult female 01day    11936 adult female 05day    15482 adult female 30day    16726 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004926    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004926 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004926 expression level Tissue   Expression Level Larval Central Nervous System    973.225 Larval Midgut    586.6 Larval Hindgut    847.1 Larval Malpighian Tubules    712 Larval Fat Body    889.6 Larval Salivary Gland    1890 Larval Trachea    1296.925 Larval Carcass    941.925 Adult Head    558.9 Adult Eye    543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop    716.6 Adult Midgut    829 Adult Hindgut    623.8 Adult Malpighian Tubules    1119 Adult Fat Body    1070.3 Adult Salivary Gland    1242.5 Adult Heart    624.15 Adult VirginFemale Spermatheca    1286.9 Adult InseminatedFemale Spermatheca    1640.1 Adult Ovary    1258 Adult Testis    519.5 Adult Male Accessory Gland    1549.3 Adult Carcass    611 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (973.225) Larval Midgut  (586.6) Larval Hindgut  (847.1) Larval Malpighian Tubules  (712) Larval Fat Body  (889.6) Larval Salivary Gland  (1890) Larval Trachea  (1296.925) Larval Carcass  (941.925) Adult Head  (558.9) Adult Eye  (543.9) Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop  (716.6) Adult Midgut  (829) Adult Hindgut  (623.8) Adult Malpighian Tubules  (1119) Adult Fat Body  (1070.3) Adult Salivary Gland  (1242.5) Adult Heart  (624.15) Adult VirginFemale Spermatheca  (1286.9) Adult InseminatedFemale Spermatheca  (1640.1) Adult Ovary  (1258) Adult Testis  519.5 Adult Male Accessory Gland  (1549.3) Adult Carcass  (611) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    973.225 Larval Midgut    586.6 Larval Hindgut    847.1 Larval Malpighian Tubules    712 Larval Fat Body    889.6 Larval Salivary Gland  (1890) Larval Trachea  (1296.925) Larval Carcass    941.925 Adult Head    558.9 Adult Eye    543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop    716.6 Adult Midgut    829 Adult Hindgut    623.8 Adult Malpighian Tubules  (1119) Adult Fat Body  1070.3 Adult Salivary Gland  (1242.5) Adult Heart    624.15 Adult VirginFemale Spermatheca  (1286.9) Adult InseminatedFemale Spermatheca  (1640.1) Adult Ovary  (1258) Adult Testis    519.5 Adult Male Accessory Gland  (1549.3) Adult Carcass    611 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    973.225 Larval Midgut    586.6 Larval Hindgut    847.1 Larval Malpighian Tubules    712 Larval Fat Body    889.6 Larval Salivary Gland    1890 Larval Trachea    1296.925 Larval Carcass    941.925 Adult Head    558.9 Adult Eye    543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop    716.6 Adult Midgut    829 Adult Hindgut    623.8 Adult Malpighian Tubules    1119 Adult Fat Body    1070.3 Adult Salivary Gland    1242.5 Adult Heart    624.15 Adult VirginFemale Spermatheca    1286.9 Adult InseminatedFemale Spermatheca    1640.1 Adult Ovary    1258 Adult Testis    519.5 Adult Male Accessory Gland    1549.3 Adult Carcass    611 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004926 expression level Tissue   Expression Level Larval Central Nervous System    973.225 Larval Midgut    586.6 Larval Hindgut    847.1 Larval Malpighian Tubules    712 Larval Fat Body    889.6 Larval Salivary Gland    1890 Larval Trachea    1296.925 Larval Carcass    941.925 Adult Head    558.9 Adult Eye    543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop    716.6 Adult Midgut    829 Adult Hindgut    623.8 Adult Malpighian Tubules    1119 Adult Fat Body    1070.3 Adult Salivary Gland    1242.5 Adult Heart    624.15 Adult VirginFemale Spermatheca    1286.9 Adult InseminatedFemale Spermatheca    1640.1 Adult Ovary    1258 Adult Testis    519.5 Adult Male Accessory Gland    1549.3 Adult Carcass    611 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (973.225) Larval Midgut  586.6 Larval Hindgut  (847.1) Larval Malpighian Tubules  712 Larval Fat Body  (889.6) Larval Salivary Gland  (1890) Larval Trachea  (1296.925) Larval Carcass  (941.925) Adult Head  558.9 Adult Eye  543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop  716.6 Adult Midgut  (829) Adult Hindgut  623.8 Adult Malpighian Tubules  (1119) Adult Fat Body  (1070.3) Adult Salivary Gland  (1242.5) Adult Heart  624.15 Adult VirginFemale Spermatheca  (1286.9) Adult InseminatedFemale Spermatheca  (1640.1) Adult Ovary  (1258) Adult Testis  519.5 Adult Male Accessory Gland  (1549.3) Adult Carcass  611 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    973.225 Larval Midgut    586.6 Larval Hindgut    847.1 Larval Malpighian Tubules    712 Larval Fat Body    889.6 Larval Salivary Gland  (1890) Larval Trachea  1296.925 Larval Carcass    941.925 Adult Head    558.9 Adult Eye    543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop    716.6 Adult Midgut    829 Adult Hindgut    623.8 Adult Malpighian Tubules  1119 Adult Fat Body  1070.3 Adult Salivary Gland  1242.5 Adult Heart    624.15 Adult VirginFemale Spermatheca  1286.9 Adult InseminatedFemale Spermatheca  1640.1 Adult Ovary  1258 Adult Testis    519.5 Adult Male Accessory Gland  1549.3 Adult Carcass    611 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    973.225 Larval Midgut    586.6 Larval Hindgut    847.1 Larval Malpighian Tubules    712 Larval Fat Body    889.6 Larval Salivary Gland    1890 Larval Trachea    1296.925 Larval Carcass    941.925 Adult Head    558.9 Adult Eye    543.9 Adult Brain    311.7 Adult Thoracic-Abdominal Ganglion    315 Adult Crop    716.6 Adult Midgut    829 Adult Hindgut    623.8 Adult Malpighian Tubules    1119 Adult Fat Body    1070.3 Adult Salivary Gland    1242.5 Adult Heart    624.15 Adult VirginFemale Spermatheca    1286.9 Adult InseminatedFemale Spermatheca    1640.1 Adult Ovary    1258 Adult Testis    519.5 Adult Male Accessory Gland    1549.3 Adult Carcass    611 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    558.9   NA  Eye    543.9   NA  Brain    311.7   973.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    315   NA  Crop    716.6   586.6  Midgut    829   847.1  Hindgut    623.8   712  Malpighian Tubules    1119   889.6  Fat Body    1070.3   1890  Salivary Gland    1242.5   NA  Heart    624.15   1296.925  Trachea    NA   NA  VirginFemale Spermatheca    1286.9   NA  InseminatedFemale Spermatheca    1640.1   NA  Ovary    1258   NA  Testis    519.5   NA  Male Accessory Gland    1549.3   941.925  Carcass    611 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004926 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4153-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal eIF-2βCC06208 lethal, with Scer\GAL4pnr-MD237 eIF-2βGD1431 eIF-2βGD16736 lethal | embryonic stage eIF-2β1 eIF-2β2 lethal | embryonic stage (with Df(3L)ED4486) eIF-2β1 eIF-2β2 Other Phenotypes Allele neuroanatomy defective | embryonic stage (with Df(3L)ED4486) eIF-2β2 neuroanatomy defective | embryonic stage (with eIF-2β1) eIF-2β2 neuroanatomy defective | embryonic stage (with eIF-2β2) eIF-2β1 Phenotype manifest in Allele axon & pCC neuron (with Df(3L)ED4486) eIF-2β2 axon & pCC neuron (with eIF-2β1) eIF-2β2 axon & pCC neuron (with eIF-2β2) eIF-2β1
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of eIF-2β Class Mutagen Stocks Known lesion eIF-2βc05909 piggyBac transposase 1 -- eIF-2βEY08063 P-element activity 1 -- eIF-2β1 P-element activity 0 Yes eIF-2β2 P-element activity 0 Yes eIF-2βCC06208 P-element activity 0 Yes eIF-2βEP745 P-element activity 0 -- eIF-2βGE06414 P-element activity 0 Yes eIF-2βGE06433 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF-2β Class Mutagen Stocks Known lesion eIF-2βGD1431 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-2βGD16736 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-2βKK108791 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-2βScer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}eIF-2βEP745 NA P{EP}eIF-2βGE06414 NA P{EP}eIF-2βGE06433 NA P{EPgy2}eIF-2βEY08063 NA miscellaneous insertions P{PTT-GC}eIF-2βCC06208 NA PBac{PB}eIF-2βc05909 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon midline choice point recognition inferred from mutant phenotype (Lee et al., 2007) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
GTP binding non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) translation initiation factor activity inferred from electronic annotation with InterPro:IPR002735, InterPro:IPR016189, InterPro:IPR016190 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) tRNA binding non-traceable author statement (Swiss-Prot Project Members, 1995.6.1)
Biological Process
CV term Evidence References
formation of translation initiation ternary complex non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) translational initiation inferred from electronic annotation with InterPro:IPR002735, InterPro:IPR016189, InterPro:IPR016190 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Lasko, 2000)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Lasko, 2000) eukaryotic translation initiation factor 2 complex inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF-2β allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64782 DroID - A comprehensive database of gene and protein interactions. • FBgn0004926 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39433
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24007 Dere\GG13816 Dgri\GH16843 Dmoj\GI13062 Dper\GL24944 Dpse\GA23566 Dsec\GM24645 Dsim\GD12709 Dvir\GJ13811 Dwil\GK12617 Dyak\GE20110
Curated drosophilid orthologs	Dpse\GA17991   Dsim\eIF-2β (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011527-PA Aedes aegypti (mosquito) AGAP007218-PA Anopheles gambiae (mosquito) XP_001943223.1 Acyrthosiphon pisum (pea aphid) At5g20920.1 Arabidopsis thaliana (wall cress) 36772 Batrachochytrium dendrobatidis (chytrid fungus) 217139 Branchiostoma floridae (lancelet) 251152 Branchiostoma floridae (lancelet) XP_001893833.1 Brugia malayi (roundworm nematode) BGIBMGA001437-PA Bombyx mori (silk worm) ENSBTAP00000007832 Bos taurus (bovine) CAL0003036 Candida albicans (a form of yeast) CN00674 Caenorhabditis brenneri (small nematode) CBP37408 Caenorhabditis briggsae (nematode) CE16227 Caenorhabditis elegans (worm) ENSCAFP00000011141 Canis familiaris (dog) CAGL0H00957g Candida glabrata (haploid yeast) Chro.80508 Cryptosporidium hominis (obligate parasite) ENSCINP00000019398 Ciona intestinalis (sea squirt) JA11834 Caenorhabditis japonica (nematode) CMH061C Cyanidioschyzon merolae (red alga) cn05069 Cryptococcus neoformans (yeast-like fungus) cgd8_4430 Cryptosporidium parvum (protozoan parasite) CPIJ011259 Culex pipens (mosquito) ENSCPOP00000013920 Cavia porcellus (guinea pig) 102338 Chlamidomonas reinhardtii (green alga) RP37845 Caenorhabditis remanei (nematode) ENSCSAVP00000019940 Ciona savignyi (sedentary tunicate) 152704 Capitella spl (polychaete worm) DDB0234112 Dictyostelium discoideum (amoeba) DEHA2D10340g Debaryomyces Hansenii (yeast) 308414 Daphnia pulex (daphnia) ENSDARP00000069494 Danio rerio (zebra fish) ENSECAP00000017148 Equus caballus (horse) XP_656368 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008099 Gymnopilus aculeatus (mushroom) ENSGALP00000039624 Gallus gallus (chicken) GL50803_91398 Giardia lamblia (flagellated protozoan) 66682 Hypsipyla robusta (cedar shoot borer) ENSP00000364119 Homo sapiens (human) KLLA0D08932g Kluyveromyces lactis (yeast) 233830 Lottia gigantea (owl limpet) LmjF08.0550 Leishmania major (virus) 33635 Monocosta brevicollis (choanoflagellate) ENSMODP00000003411 Monodelphis domestica (gray opossum) ENSMMUP00000023780 Macaca mulatta (rhesus monkey) ENSMUSP00000070944 Mus musculus (house mouse) ENSMUSP00000096777 Mus musculus (house mouse) 229337 Nematostella vectensis (starlet anemone) XP_001605915.1 Nasonia vitripennis (wasp) ENSOANP00000020413 Ornithorynchus anatinus (platypus) ENSORLP00000004417 Oryzias latipes (japanese killifish) LOC_Os07g48300.1 Oryza sativa (asian rice) 6506 Ostreococcus tauri (green alga) PF10_0103 Plasmodium falciparum (protozoal parasite) PHUM006132-PA Pediculus humanus (human body louse) PP21567 Pristionchus pacificus (nematode) 213842 Physcomitrella patens (moss) ENSPPYP00000012209 Pongo pygmaeus (orangutan) 75080 Phytophthora ramorum (sudden oak death pathogen) 834674 Populus trichocarpa (black cottonwood) ENSPTRP00000022998 Pan troglodytes (chimpanzee) PVX_094750 Plasmodium vivax (protozoal parasite) ENSRNOP00000023786 Rattus norvegicus (norway rat) 148016 Sorghum bicolor (sorghum) YPL237W Saccharomyces cerevisiae (budding yeast) Smp_103460.1 Schistosoma mansoni (trematode parasite) SPAC32A11.04c Schizosaccharomyces pombe (fission yeast) XP_001202202.1 Strongylocentrotus purpuratus (purple sea urchin) 23922 Trichoplax adhaerens (metazoa) TA14525 Theileria annulata (apicomplexan parasite) XP_966454.1 Tribolium castaneum (red flour beetle) Tc00.1047053503955.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507063.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014974 Tetraodon nigroviridis (green spotted pufferfish) TP02_0678 Theileria parva (parasitic protozoan) 36456 Thalassiosira pseudonana (marine diatom) ENSTRUP00000006244 Takifugu rubripes (pufferfish Takifugu) 3738.m00028 Tetrahymena thermophila (ciliate protozoa) 85889.m00521 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000042239 Xenopus tropicalis (frog) YALI0E31691g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15146 NV16557 LH21044 FBgn0237433 FBgn0214626 FBgn0201030 FBgn0184436 FBgn0179508 JGI_V11_308414 FBgn0244966 FBgn0162531 FBgn0135819 FBgn0124314 FBgn0106079 FBgn0101001 CPIJ013860 CPIJ011259 BGIBMGA001437 ACYPI004549 GB10155 AGAP007218 AAEL011527 PHUM019470 GLEAN_04029
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	17425 y1 w67c23; P{EPgy2}eIF-2βEY08063/TM3, Sb1 Ser1
Harvard	- PBac{PB}eIF-2βc05909
VDRC	v105291 P{KK108791}VIE-260B v9416 w1118; P{GD1431}v9416/TM3 v48911 w1118; P{GD16736}v48911/CyO
Genomic Clones ( 1 )
	BACR48G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 122 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD35750 RE29270
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02354 GH04004 GH07913 GH11429 GH12211 GH21624 GH25491 GM01015 GM12188 GM28248 LD36580 LD45507 LP03668 LP08701 LP09865 LP11772 RE12542 RE25143 RE28046 RE38748 RE49829 RE56683 RH01862 RH55052 RH73295 SD02683 SD09767 SD18903 SD18963 SD19034 SD19055
Other clones	62771 106826 120140 148087 160633 193036 571145 bs32g12 bs41b07 bs54a01 Dmel_dig_006855_0612_0912 Dmel_dig_011946_0644_3496 Dmel_dig_013410_0634_0833 Dmel_dig_014232_0708_3304 Dmel_dig_016397_0638_1842 Dmel_neb_001532_0169_0337 Dmel_neb_006984_0452_0790 Dmel_neb_011371_0084_1869 Dmel_neb_011577_0343_1552 Dmel_neb_013845_0192_2067 EC32126 EK188517 EK240058 EK242258 EK253436 EK264330 EK296016 FGH111B06 FGH119D07 FGM004F10 IP07773 IP07873 RP003021694 RP003035435 RP003044574 RP003045488 RP003052619 RP003052761 RP003060207 RP003075605 RP003098764 RP003112703 RP003113410 RP003121405 RP003134292 RP003156436 RP003164120 RP003169146 RP003201584 RP003201755 RP003209636 RP003230859 RP003236627 RP003236971 RP003242444 RP003255240 RP003260690 RP003270336 RP003282067 RP003283794 RP003289222 RP003312624 RP003313033 RP003319278 RP003331074 RP003368095 RP003376701 RP003377287 RP003384989 RP003396563 RP003401817 RP003403954 RP003425036 RP003450590 RP003451329 RP003478982 RP003520858 RP003522272 RP003526461 RP003543703 RP003555966 RP003577031 RP003580653 RP003603342 RP003605136 RP003618775 RP003652337 RP003659037 RP003662000
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004926 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39433
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Not haploinsufficient. (Marygold et al., 2007) dsRNA made from templates generated with primers directed against eIF-2β that is transfected into S2 treated with Listeria monocytogenes reveals eIF-2β to be involved in Listeria monocytogenes vacuolar escape. (Cheng et al., 2005) eIF-2β has been isolated and characterised. (Ye and Cavener, 1994) eIF-2β nucleotide sequence displays a high degree of similarity with the human and yeast homologs. eIF-2β mRNA displays quasi-constitutive expression. (Ye et al., 1992) eIF-2β mRNA displays quasi-constitutive expression.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079319 RefSeq (Proteins) • NP_524043 DDBJ / EMBL / GenBank • AAA28504 AAF49902 AAL48875 AI531586 AI946908 AQ254621 AY071253 BI233005 CL525980 CZ470350 L19197 Entrez Gene - A searchable database of RefSeq genes. • 39433 UniProtKB/Swiss-Prot • P41375
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Translation initiation factor IF2/IF5 (IPR002735) Translation initiation factor IF2/IF5, N-terminal (IPR016189) Translation initiation factor IF2/IF5, zinc-binding (IPR016190)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64782 DroID - A comprehensive database of gene and protein interactions. • FBgn0004926 DRSC - Results from RNAi screens. • FBgn0004926 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004926 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4153-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004926 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39433 InParanoid A subset of ortholog calls from InParanoid. • AAEL011527-PA Aedes aegypti (mosquito) AGAP007218-PA Anopheles gambiae (mosquito) XP_001943223.1 Acyrthosiphon pisum (pea aphid) At5g20920.1 Arabidopsis thaliana (wall cress) 36772 Batrachochytrium dendrobatidis (chytrid fungus) 217139 Branchiostoma floridae (lancelet) 251152 Branchiostoma floridae (lancelet) XP_001893833.1 Brugia malayi (roundworm nematode) BGIBMGA001437-PA Bombyx mori (silk worm) ENSBTAP00000007832 Bos taurus (bovine) CAL0003036 Candida albicans (a form of yeast) CN00674 Caenorhabditis brenneri (small nematode) CBP37408 Caenorhabditis briggsae (nematode) CE16227 Caenorhabditis elegans (worm) ENSCAFP00000011141 Canis familiaris (dog) CAGL0H00957g Candida glabrata (haploid yeast) Chro.80508 Cryptosporidium hominis (obligate parasite) ENSCINP00000019398 Ciona intestinalis (sea squirt) JA11834 Caenorhabditis japonica (nematode) CMH061C Cyanidioschyzon merolae (red alga) cn05069 Cryptococcus neoformans (yeast-like fungus) cgd8_4430 Cryptosporidium parvum (protozoan parasite) CPIJ011259 Culex pipens (mosquito) ENSCPOP00000013920 Cavia porcellus (guinea pig) 102338 Chlamidomonas reinhardtii (green alga) RP37845 Caenorhabditis remanei (nematode) ENSCSAVP00000019940 Ciona savignyi (sedentary tunicate) 152704 Capitella spl (polychaete worm) DDB0234112 Dictyostelium discoideum (amoeba) DEHA2D10340g Debaryomyces Hansenii (yeast) 308414 Daphnia pulex (daphnia) ENSDARP00000069494 Danio rerio (zebra fish) ENSECAP00000017148 Equus caballus (horse) XP_656368 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000008099 Gymnopilus aculeatus (mushroom) ENSGALP00000039624 Gallus gallus (chicken) GL50803_91398 Giardia lamblia (flagellated protozoan) 66682 Hypsipyla robusta (cedar shoot borer) ENSP00000364119 Homo sapiens (human) KLLA0D08932g Kluyveromyces lactis (yeast) 233830 Lottia gigantea (owl limpet) LmjF08.0550 Leishmania major (virus) 33635 Monocosta brevicollis (choanoflagellate) ENSMODP00000003411 Monodelphis domestica (gray opossum) ENSMMUP00000023780 Macaca mulatta (rhesus monkey) ENSMUSP00000070944 Mus musculus (house mouse) ENSMUSP00000096777 Mus musculus (house mouse) 229337 Nematostella vectensis (starlet anemone) XP_001605915.1 Nasonia vitripennis (wasp) ENSOANP00000020413 Ornithorynchus anatinus (platypus) ENSORLP00000004417 Oryzias latipes (japanese killifish) LOC_Os07g48300.1 Oryza sativa (asian rice) 6506 Ostreococcus tauri (green alga) PF10_0103 Plasmodium falciparum (protozoal parasite) PHUM006132-PA Pediculus humanus (human body louse) PP21567 Pristionchus pacificus (nematode) 213842 Physcomitrella patens (moss) ENSPPYP00000012209 Pongo pygmaeus (orangutan) 75080 Phytophthora ramorum (sudden oak death pathogen) 834674 Populus trichocarpa (black cottonwood) ENSPTRP00000022998 Pan troglodytes (chimpanzee) PVX_094750 Plasmodium vivax (protozoal parasite) ENSRNOP00000023786 Rattus norvegicus (norway rat) 148016 Sorghum bicolor (sorghum) YPL237W Saccharomyces cerevisiae (budding yeast) Smp_103460.1 Schistosoma mansoni (trematode parasite) SPAC32A11.04c Schizosaccharomyces pombe (fission yeast) XP_001202202.1 Strongylocentrotus purpuratus (purple sea urchin) 23922 Trichoplax adhaerens (metazoa) TA14525 Theileria annulata (apicomplexan parasite) XP_966454.1 Tribolium castaneum (red flour beetle) Tc00.1047053503955.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507063.20 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000014974 Tetraodon nigroviridis (green spotted pufferfish) TP02_0678 Theileria parva (parasitic protozoan) 36456 Thalassiosira pseudonana (marine diatom) ENSTRUP00000006244 Takifugu rubripes (pufferfish Takifugu) 3738.m00028 Tetrahymena thermophila (ciliate protozoa) 85889.m00521 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000042239 Xenopus tropicalis (frog) YALI0E31691g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39433 modMine - Data generated by the modENCODE project. • FBgn0004926 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15146 NV16557 LH21044 FBgn0237433 FBgn0214626 FBgn0201030 FBgn0184436 FBgn0179508 JGI_V11_308414 FBgn0244966 FBgn0162531 FBgn0135819 FBgn0124314 FBgn0106079 FBgn0101001 CPIJ013860 CPIJ011259 BGIBMGA001437 ACYPI004549 GB10155 AGAP007218 AAEL011527 PHUM019470 GLEAN_04029
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG4153 (Cheng et al., 2005, Lasko, 2000, Goshima et al., 2007, Keleman et al., 2009.8.5, Hughes et al., 2008) D-eIF2β (Myrick and Dearolf, 2000) eIF-2 (Zapata et al., 1991, Goshima et al., 2007) eIF-2beta (Giot et al., 2003, Gruenewald et al., 2009, Buszczak et al., 2007) eIF2β (Lasko, 2000, Lee et al., 2007) Eif2β   eIF-2β (Marygold et al., 2007) elF2β (Ye et al., 1992, Lee et al., 2007) IF2B (Mushegian et al., 1998)
Name Synonym	Eukaryotic initiation factor 2β
Secondary FlyBase IDs
	FBgn0024970
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Show all research papers ...