upd, unpaired, os, sisC, outstretched
Gene model reviewed during 5.52
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.43
Gene model reviewed during 5.42
Gene model reviewed during 5.56
2.2 (northern blot)
413 (aa); 47 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\upd1 using the Feature Mapper tool.
upd1 transcript is expressed in the proximal fold, and two domains of the medial fold, of the wing hinge primordium, and in a small domain corresponding to the ventral body wall.
Brief segmental upd1 expression is detected in the ventral ectoderm at embryonic stage 9. In stages 10-12, upd1 is expressed in the developing tracheal system and in the hindgut and is not longer seen in the ventral ectoderm. No expression is observed in the dorsal ectoderm or dorsal mesoderm.
upd1 localizes to hub-proximal germ cells in the anterior half of the gonad in stage 17 embryos.
os transcripts become abundant shortly before cellularization at which time they are present in the trunk region and in an incomplete head stripe but not in the termini. At cellularization, the trunk region expression resolves into 7 stripes. In early gastrulation, 14 stripes appear. In later stages, expression is largely restricted to the tracheal pits.
GBrowse - Visual display of RNA-Seq signalsView Dmel\upd1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: os CG5993
Source for merge of: os sisC
Classical alleles of the 'os' (outstretched) complementation group affect expression of both the upd1 and upd3 genes and map to untranscribed regions, suggesting that they disrupt regulatory elements shared by both genes.
"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3").
upd1 is required to maintain basal turnover of the midgut epithelium by controlling intestinal stem cell maintenance in an autocrine manner.
Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.
upd1 protein, secreted by the polar follicle cells, may act as a morphogen to specify anterior-posterior pattern in the ovarian follicle cells.
upd1 is required for self-renewal of male germ line stem cells and somatic cyst progenitor cells.
A localised source of upd1 protein, which is present at the midline of the developing eye, is capable of activating the JAK/STAT pathway over long distances.
γ ray induced loss of function mutations suppress male-lethal duplications of numerator elements.
The os gene has been studied as part of a genetic and developmental study of polytene section 17 of the X chromosome. A duplication of this region, fcl+Y, has been constructed to allow mutagenesis screens and complementation analyses of the region.