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General Information
Symbol
Dmel\upd1
Species
D. melanogaster
Name
unpaired 1
Annotation Symbol
CG5993
Feature Type
FlyBase ID
FBgn0004956
Gene Model Status
Stock Availability
Gene Snapshot
unpaired 1 (upd1) encodes a secreted glycol-protein that is able to act at a distance as the primary ligand of the JAK/STAT signaling pathway. Although semi-redundant with upd2 and upd3, upd1 depletion results in embryonic lethality with an atypical gap gene-like segmentation phenotype. [Date last reviewed: 2019-03-21]
Also Known As
upd, unpaired, os, sisC, outstretched
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:18,305,354..18,309,291 [-]
Recombination map
1-60
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
UNPAIRED FAMILY -
The Unpaired (UPD) family encodes the only known cytokines capable of activating the JAK/STAT pathway in D.mel, by binding the receptor dome. This pathway is involved in cell proliferation, embryonic development and stem cell maintenance. (Adapted from FBrf0232479, FBrf0213113 and FBrf0219535).
Pathway (FlyBase)
JAK-STAT Signaling Pathway Core Components -
The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
os: outstretched small eye
Wings held virtually at right angles to body. Eyes small and rounded. os/oso has wing effect but eyes normal. os/oss has eye effect but wings normal. RK1.
osbdw: outstretched small eye-bending wings
Wings divergent and drooping, size and shape normal. Males sterile. RK2A.
oso: outstretched small eye-outstretched
thumb
oso: outstretched small eye-outstretched
Edith M. Wallace, unpublished.
Wings extremely divergent, often at right angles to body. oso/oss is wild type. RK1.
oss: outstretched small eye-small eye
Eyes small and rounded, high on the head but not bulging. RK1.
upd: unpaired
Embryonic lethal. Mutants show variable larval cuticular phenotype with defects predominantly in the mesothorax and the fifth abdominal segment (Nusslein-Volhard et al., 1984; Gergen and Wieschaus, 1986); also some head defects and fourth, sixth, seventh, and eighth abdominal segment defects. Heterozygotes show 88-93% viability (Wieschaus and Noell, 1986).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\upd1 or the JBrowse view of Dmel\upd1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.52
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.43
Gene model reviewed during 5.42
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074581
2642
413
FBtr0112847
2443
413
FBtr0343592
2602
413
Additional Transcript Data and Comments
Reported size (kB)
2.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074353
47.0
413
12.00
FBpp0111760
47.0
413
12.00
FBpp0310189
47.0
413
12.00
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

413 aa isoforms: upd1-PA, upd1-PB, upd1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
413 (aa); 47 (kD predicted)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\upd1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (33 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from genetic interaction with FLYBASE:dome; FB:FBgn0043903
inferred from physical interaction with UniProtKB:M9NF14
Terms Based on Predictions or Assertions (0 terms)
Biological Process (27 terms)
Terms Based on Experimental Evidence (24 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from high throughput mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:A1YK24,UniProtKB:Q9VCH5,UniProtKB:Q9VCH5
(assigned by UniProt )
inferred from mutant phenotype
inferred from high throughput mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:hop; FB:FBgn0004864
inferred from genetic interaction with FLYBASE:Stat92E; FB:FBgn0016917
inferred from genetic interaction with FLYBASE:Socs36E; FB:FBgn0041184
inferred from genetic interaction with FLYBASE:dome; FB:FBgn0043903
inferred from genetic interaction with FLYBASE:Ptp61F; FB:FBgn0267487
inferred from mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
distribution deduced from reporter (Gal4 UAS)
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
upd1 transcript is expressed in the proximal fold, and two domains of the medial fold, of the wing hinge primordium, and in a small domain corresponding to the ventral body wall.
Brief segmental upd1 expression is detected in the ventral ectoderm at embryonic stage 9. In stages 10-12, upd1 is expressed in the developing tracheal system and in the hindgut and is not longer seen in the ventral ectoderm. No expression is observed in the dorsal ectoderm or dorsal mesoderm.
upd1 localizes to hub-proximal germ cells in the anterior half of the gonad in stage 17 embryos.
os transcripts become abundant shortly before cellularization at which time they are present in the trunk region and in an incomplete head stripe but not in the termini. At cellularization, the trunk region expression resolves into 7 stripes. In early gastrulation, 14 stripes appear. In later stages, expression is largely restricted to the tracheal pits.
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
os protein localizes to the extracellular matrix.
upd1 protein is present in the mushroom bodies and accumulates in the calyx, although it covers a broader brain region.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}E132
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}PD
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{upd1-GAL4.U}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\upd1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of upd1
Transgenic constructs containing regulatory region of upd1
Deletions and Duplications ( 25 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
cuticle & adult external head, with Scer\GAL4ey.PH
gonad | ectopic & embryo
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190B0G )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506RO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06XE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombus impatiens
Common eastern bumble bee
Megachile rotundata
Alfalfa leafcutting bee
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 
In a tuberculosis model by abdominal injection with Mycobacterium marinum, Ab(1)oss (affecting both upd1, upd3) homozygous mutant adult flies present a significant decrease in the bacterial burden, and significant increases in the survival and hemocyte numbers upon infection, as compared to wild-type control flies.
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
JAK-STAT Signaling Pathway Core Components -
The JAK-STAT signaling pathway is initiated by the binding of an extracellular ligand to a cell surface receptor leading to receptor dimerization and the intracellular activation of a Janus kinase (JAK) family member. JAK phosphorylates cytoplasmic STAT family members which dimerize, translocate into the nucleus and regulate target gene expression. In Drosophila, the core pathway is limited to three ligands (the Unpaired family of cytokines), a single receptor (dome), JAK kinase (hop) and STAT (Stat92E). (Adapted from FBrf0225259).
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-60
Cytogenetic map
Sequence location
X:18,305,354..18,309,291 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
17A5-17A5
Limits computationally determined from genome sequence between P{EP}ari-1EP317 and P{EP}EP1378
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
17A5-17A7
17A-17A
(determined by in situ hybridisation)
17A5-17A8
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Mapping based on oso.
Stocks and Reagents
Stocks (35)
Genomic Clones (12)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    monoclonal
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for identity of: os CG5993
    Source for database merge of
    Source for merge of: os sisC
    Additional comments
    Classical alleles of the 'os' (outstretched) complementation group affect expression of both the upd1 and upd3 genes and map to untranscribed regions, suggesting that they disrupt regulatory elements shared by both genes.
    "upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3").
    Other Comments
    upd1 is required to maintain basal turnover of the midgut epithelium by controlling intestinal stem cell maintenance in an autocrine manner.
    Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.
    upd1 protein, secreted by the polar follicle cells, may act as a morphogen to specify anterior-posterior pattern in the ovarian follicle cells.
    upd1 is required for self-renewal of male germ line stem cells and somatic cyst progenitor cells.
    upd1 acts as an X-linked signal element in sex determination.
    A localised source of upd1 protein, which is present at the midline of the developing eye, is capable of activating the JAK/STAT pathway over long distances.
    upd1 is necessary to determine the position of the eye equator via regulation of mirr.
    γ ray induced loss of function mutations suppress male-lethal duplications of numerator elements.
    The os gene has been studied as part of a genetic and developmental study of polytene section 17 of the X chromosome. A duplication of this region, fcl+Y, has been constructed to allow mutagenesis screens and complementation analyses of the region.
    upd1 mutants display defects predominantly in mesothorax and fifth row, head defects and eighth segment defects.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 43 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (31)
    Reported As
    Symbol Synonym
    Upd
    (Powers and Srivastava, 2019, Ahmed-de-Prado and Baonza, 2018, Enomoto et al., 2018, Mehrotra and Deshpande, 2018, Perochon et al., 2018, Richardson and Portela, 2018, Stuelten et al., 2018, Wu et al., 2018, Feng et al., 2017, Kashio et al., 2017, Khanna et al., 2017, Kim et al., 2017, Tamori and Deng, 2017, Deshpande et al., 2016, Fisher et al., 2016, Jiang et al., 2016, Mbodj et al., 2016, Yadav et al., 2016, Dorn and Dorn, 2015, Enomoto et al., 2015, Greenspan et al., 2015, Merkling et al., 2015, Nie et al., 2015, Seeds et al., 2015, Thomas et al., 2015, Wang et al., 2015, Chabu and Xu, 2014, Chen et al., 2014, Huang et al., 2014, Tamori and Deng, 2014, Ayyaz and Jasper, 2013, Bausek, 2013, Hombría and Sotillos, 2013, Li et al., 2013, Morin-Poulard et al., 2013, Pastor-Pareja and Xu, 2013, Ren et al., 2013, Sato et al., 2013, Shim et al., 2013, Southall et al., 2013, Takashima et al., 2013, Yamashita, 2013, Zeidler and Bausek, 2013, Zhou et al., 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Grönholm et al., 2012, Hayashi et al., 2012, Kounatidis and Ligoxygakis, 2012, Lim et al., 2012, Luo and Sehgal, 2012, Matunis et al., 2012, Monk et al., 2012, White-Cooper, 2012, Zoller and Schulz, 2012, Apidianakis and Rahme, 2011, Buechling et al., 2011, Jiang et al., 2011, Stec and Zeidler, 2011, Van De Bor et al., 2011, Willecke et al., 2011, Wright et al., 2011, Yoon et al., 2011, Bina et al., 2010, Lin et al., 2010, Ren et al., 2010, Akbar et al., 2009, Gilbert et al., 2009, González et al., 2009, Jiang et al., 2009, Sheng et al., 2009, Vaccari et al., 2009, Kim et al., 2008, Rivas et al., 2008, Yamashita and Fuller, 2008, Fuller and Spradling, 2007, Luque and Milan, 2007, Nurminsky, 2007, Pei and Harrison, 2007, Tolwinski, 2007, Tsai et al., 2007, Yasugi et al., 2007, Bartscherer et al., 2006, Bina and Zeidler, 2006, Giebel and Wodarz, 2006, Sexton et al., 2006, Wong et al., 2006, Baeg et al., 2005, Moberg et al., 2005, Muller et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Thompson et al., 2005, Vaccari and Bilder, 2005, Yamashita et al., 2005, Zeidler et al., 2005, Zhang and Li, 2005, Ekas and Bach, 2004, Fuchs et al., 2004, Gilboa and Lehmann, 2004, Oh et al., 2004, Read et al., 2004, Sexton et al., 2004, Agaisse et al., 2003, Arbouzova et al., 2003, Denef and Schupbach, 2003, Hultmark and Ekengren, 2003, Mukherjee and Zeidler, 2003, Wallenfang and DiNardo, 2003, Xi et al., 2003, Kisseleva et al., 2002, Tulina and Matunis, 2002, Xi and Harrison, 2002, Tulina and Matunis, 2001, Blair, 1999, Zeidler et al., 1999, Zeidler et al., 1999)
    l(1)YC43
    l(1)YM55
    odsy
    upd
    (Sreejith et al., 2019, Wittes and Schüpbach, 2019, Fisher et al., 2018, Palmer et al., 2018, Parvy et al., 2018, Petrovsky and Großhans, 2018, Saadin and Starz-Gaiano, 2018, Recasens-Alvarez et al., 2017, Takemura and Nakato, 2017, Torres et al., 2017, Vollmer et al., 2017, Saadin and Starz-Gaiano, 2016, Shen et al., 2016, Singh et al., 2016, Barr et al., 2015, Das and Dobens, 2015, Glassford et al., 2015, Katsuyama et al., 2015, Matsuda et al., 2015, Pasco et al., 2015, Ren et al., 2015, Santabárbara-Ruiz et al., 2015, Singh, 2015, Sun et al., 2015, Tataroglu and Emery, 2015, Tsai et al., 2015, Wan et al., 2015, Zang et al., 2015, Li et al., 2014, Lin et al., 2014, Okumura et al., 2014, Scopelliti et al., 2014, Shields et al., 2014, Sopko et al., 2014, Wang et al., 2014, Xu and Cherry, 2014, Aleksic et al., 2013, Guo et al., 2013, Hombría and Serras, 2013, Hombría and Sotillos, 2013, Katsuyama et al., 2013, Kemp et al., 2013, Lin et al., 2013, Lucas et al., 2013, Morillo Prado et al., 2013, Sinha et al., 2013, Wang et al., 2013, Wells et al., 2013, Yadlapalli and Yamashita, 2013, Zeidler and Bausek, 2013, Zhang et al., 2013, Zoranovic et al., 2013, Herranz et al., 2012, Issigonis and Matunis, 2012, Matunis et al., 2012, Toledano et al., 2012, Toledano et al., 2012, Tran et al., 2012, Wong and Jones, 2012, Casper et al., 2011, Copf et al., 2011, de Cuevas and Matunis, 2011, Feng et al., 2011, Johnson et al., 2011, Kim et al., 2011, Morris and Spradling, 2011, Parrott et al., 2011, Sinenko et al., 2011, Singh et al., 2011, Stec and Zeidler, 2011, Sun et al., 2011, Uddin et al., 2011, Wang et al., 2011, Wang et al., 2011, Wright et al., 2011, Yuva-Aydemir et al., 2011, Zheng et al., 2011, Beebe et al., 2010, Flaherty et al., 2010, Gladstein et al., 2010, Goto et al., 2010, Kallio et al., 2010, Liu et al., 2010, Martinez and Cavalli, 2010, Ngo et al., 2010, Shaw et al., 2010, Singh et al., 2010, Sotillos et al., 2010, Wu et al., 2010, Zhai et al., 2010, Almudi et al., 2009, Bertet et al., 2009, Casper and Van Doren, 2009, Classen et al., 2009, Cronin et al., 2009, Flaherty et al., 2009, Gutierrez-Aviño et al., 2009, Papagiannouli and Mechler, 2009, Sheng et al., 2009, Smith-Bolton et al., 2009, Wang and Huang, 2009, Cinnamon et al., 2008, Copf and Preat, 2008, Duong et al., 2008, Leatherman and DiNardo, 2008, López-Onieva et al., 2008, Pastor-Pareja et al., 2008, Sexton and Harrison, 2008, Sotillos et al., 2008, Voog et al., 2008, Wang and Harrison, 2008, Wang et al., 2008, Wang et al., 2008, Yasugi et al., 2008, Assa-Kunik et al., 2007, Avila and Erickson, 2007, Ayala-Camargo et al., 2007, Bach et al., 2007, Boyle et al., 2007, Devergne et al., 2007, Flaherty et al., 2007, Furriols et al., 2007, Grieder et al., 2007, Sexton and Harrison, 2007, Singh et al., 2007, Tsai et al., 2007, Tsai et al., 2007, Wang and Harrison, 2007, Wang et al., 2007, Arbouzova et al., 2006, Brown et al., 2006, DEVERGNE and NOSELLI, 2006, Ekas et al., 2006, Ekas et al., 2006, Herz, 2006, Herz et al., 2006, Keller, 2006, Lovegrove et al., 2006, Lovegrove et al., 2006, Montell, 2006, Mukherjee et al., 2006, Singh et al., 2006, Singh et al., 2006, Wang et al., 2006, Wang et al., 2006, Zheng et al., 2006, Davies et al., 2005, Decotto and Spradling, 2005, Ekas and Bach, 2005, Gilbert et al., 2005, Grieder et al., 2005, Hombria et al., 2005, Liu and Sun, 2005, Mukherjee et al., 2005, Muller, 2005, Reynolds-Kenneally and Mlodzik, 2005, Sexton et al., 2005, Tsai and Sun, 2005, Wang, 2005, Wang et al., 2005, Wawersik et al., 2005, Xie et al., 2005, Agaisse and Perrimon, 2004, Josten et al., 2004, Rawlings et al., 2004, Starz-Gaiano and Montell, 2004, Tsai and Sun, 2004, Tsai and Sun, 2004, Yamashita et al., 2004, Bach et al., 2003, Brown et al., 2003, Chen et al., 2003, Johansen et al., 2003, Johansen et al., 2003, Johansen et al., 2003, Li et al., 2003, Maines et al., 2003, Tulina et al., 2003, Xi et al., 2003, Adler, 2002, Bach and Perrimon, 2002, Bach and Perrimon, 2002, Badenhorst et al., 2002, Beccari et al., 2002, Castelli-Gair Hombria and Brown, 2002, Chen et al., 2002, Chen et al., 2002, Ghiglione et al., 2002, Grammont and Irvine, 2002, Green et al., 2002, Harrison et al., 2002, Harrison et al., 2002, Hou et al., 2002, Johansen et al., 2002, Karsten et al., 2002, Lengyel and Iwaki, 2002, Lin, 2002, McGregor et al., 2002, Zhao and Garbers, 2002, Zheng and Hou, 2002, Brown et al., 2001, Iwaki et al., 2001, Johansen et al., 2001, Johansen et al., 2001, Jones et al., 2001, Kiger et al., 2001, Luo and Dearolf, 2001, Silver and Montell, 2001, Spradling et al., 2001, Tsai and Sun, 2001, Xi and Harrison, 2001, Bach et al., 2000, Jinks et al., 2000, Morey et al., 2000, Xi and Harrison, 2000, Zeidler et al., 2000, Bach et al., 1999, Dearolf, 1999, Keating and Harrison, 1999, Morey and Harrison, 1999, Savant-Bhonsale et al., 1999, Tsai and Sun, 1999, Zeidler et al., 1999, Zeidler et al., 1999, Harrison et al., 1998, Mathey-Prevot et al., 1998, Morey and Harrison, 1998, Sefton et al., 1998, Harrison and Perrimon, 1997, McCoon and Gilman, 1997, Sefton et al., 1997, Cline and Meyer, 1996, Harbecke and Lengyel, 1995, Klingler and Gergen, 1993, Parkhurst and Ish-Horowicz, 1991, Perrimon et al., 1989, DiNardo and O'Farrell, 1987, Carroll and Scott, 1986, Wieschaus et al., 1984)
    Name Synonyms
    Unpaired/Out-stretched
    outstretched small eye
    outstretched-smalleye
    sisterless c
    small-eye
    upd homolog
    Secondary FlyBase IDs
    • FBgn0003012
    • FBgn0003956
    • FBgn0016985
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (559)