• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\os

General Information
Symbol	Dmel\os	Species	D. melanogaster
Name	outstretched	Annotation symbol	CG5993
Feature type	protein_coding_gene	FlyBase ID	FBgn0004956
Gene Model Status	Current	Stock availability	34 publicly available
Also Known As	Upd, sisC, sis-c, upd1
Genomic Location
Chromosome (arm)	X	Recombination map	1-58.7
Cytogenetic map	17A5-17A5	Sequence location	X:18,199,387..18,203,175 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene outstretched is referred to in FlyBase by the symbol Dmel\os (CG5993, FBgn0004956). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: morphogen activity; receptor binding; cytokine activity. There is experimental evidence for 14 unique biological process terms, many of which group under: anatomical structure development; biological regulation; cellular process involved in reproduction; digestive tract development; localization; multicellular organismal reproductive process; organ morphogenesis; cell division; memory; cell-cell signaling; apical constriction; multicellular organismal process. 39 alleles are reported. The phenotypes of these alleles are annotated with: organ system; female germline cyst; embryonic segment; thoracic segment; organ system subdivision; imaginal precursor; embryonic abdomen; adult segment; multicellular structure; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1633968_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of os. Gene sequence location is X:18199387..18203175.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	os: outstretched small eye Wings held virtually at right angles to body. Eyes small and rounded. os/oso has wing effect but eyes normal. os/oss has eye effect but wings normal. RK1. osbdw: outstretched small eye-bending wings Wings divergent and drooping, size and shape normal. Males sterile. RK2A. oso: outstretched small eye-outstretched oso: outstretched small eye-outstretched Edith M. Wallace, unpublished. Wings extremely divergent, often at right angles to body. oso/oss is wild type. RK1. oss: outstretched small eye-small eye Eyes small and rounded, high on the head but not bulging. RK1. upd: unpaired Embryonic lethal. Mutants show variable larval cuticular phenotype with defects predominantly in the mesothorax and the fifth abdominal segment (Nusslein-Volhard et al., 1984; Gergen and Wieschaus, 1986); also some head defects and fourth, sixth, seventh, and eighth abdominal segment defects. Heterozygotes show 88-93% viability (Wieschaus and Noell, 1986).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Zheng et al., 2011, Dev. Biol. 357(1): 202--210
FB2012_01	References Willecke et al., 2011, Oncogene 30(39): 4067--4074 Parrott et al., 2011, PLoS ONE 6(9): e25087 Sequence features BKN33230 HFA20358
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 17A5-17A5   Limits computationally determined from genome sequence between P{EP}ari-1EP317 and P{EP}EP1378
Experimentally Determined Cytological Location
Cytogenetic map Notes References 17A5-17A7     (Sefton, 2000.2.4) 17A-17A     (Harrison, 1998.6.17) 17A-17A   (determined by in situ hybridisation)   (Cline, 1993) 17A5-17A8   (determined by in situ hybridisation)   (Eberl et al., 1992)
Experimentally Determined Recombination Data
Location	1-59.2 (University of Buenos Aires, 1951, Bridges and Brehme, 1944) 1-58.7 (Cline, 1993)
Left of (cM)
Right of (cM)
Notes	Mapping based on oso. (Bridges and Brehme, 1944) Mapping based on osupd-1.
Gene Model & Products
Please see the GBrowse view of Dmel\os for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42 Gene model reviewed during 5.43 DGC clone AT13666 appears problematic: incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) os-RA FBtr0074581  NM_080356   2520   413 os-RB FBtr0112847  NM_001103545   2456   413
Additional Transcript Data & Comments
Reported size (kB)	2.2 (northern blot) (Harrison et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein os-PA   FBpp0074353   47.0   413   12.00     NP_525095   AAF48823 os-PB   FBpp0111760   47.0   413   12.00     NP_001097015   ABW09444
Additional Polypeptide Data & Comments
Reported size (kDa)	413 (aa); 47 (kD predicted) (Harrison et al., 1998)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF48823   AE014298 ABW09444   AF072823 AAC69620   AF231684 AAF61221   AY113249 AAM29254   BF487975   BF499160   CO312270   DQ327779   EC202224
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96525 Q8MZC7 Q9VWW4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 5   organism | pair rule expression pattern   (Harrison et al., 1998) embryonic stage 6 -- 7   organism | segment polarity expression pattern   (Harrison et al., 1998) embryonic stage 9 -- 17   tracheal pit   (Harrison et al., 1998) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 5   organism | 20-80% egg length   (Savant-Bhonsale et al., 1999) organism | anterior & dorsal   (Savant-Bhonsale et al., 1999) embryonic stage 10 -- 11   organism | segmentally repeated & striped   (Savant-Bhonsale et al., 1999) embryonic stage 13   small intestine primordium   (Iwaki et al., 2001) embryonic stage 13 -- 14   imaginal precursor   (Savant-Bhonsale et al., 1999) embryonic stage 14   ectoderm of pharynx   (Hombria et al., 2005) ectoderm of hindgut   (Hombria et al., 2005)
Additional Descriptive Data
	os transcripts become abundant shortly before cellularization at which time they are present in the trunk region and in an incomplete head stripe but not in the termini. At cellularization, the trunk region expression resolves into 7 stripes. In early gastrulation, 14 stripes appear. In later stages, expression is largely restricted to the tracheal pits. (Harrison et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	os protein localizes to the extracellular matrix. (Harrison et al., 1998)
Marker for
Subcellular Localization
CV Term	extracellular matrix (Harrison et al., 1998)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0004956    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0004956 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0004956 expression level Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr    2509 embryo 04-06hr    1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (193) embryo 02-04hr  (2509) embryo 04-06hr  (1904) embryo 06-08hr  (844) embryo 08-10hr  (513) embryo 10-12hr  (274) embryo 12-14hr  (225) embryo 14-16hr  (143) embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr  (165) white prepupae 24hr  (303) pupae 2d postWPP  (136) pupae 3d postWPP    77 pupae 4d postWPP  105 adult male 01day  (124) adult male 05day  (201) adult male 30day  (187) adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr  (2509) embryo 04-06hr  (1904) embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr    2509 embryo 04-06hr    1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr    2509 embryo 04-06hr    1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0004956 expression level Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr    2509 embryo 04-06hr    1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (193) embryo 02-04hr  (2509) embryo 04-06hr  (1904) embryo 06-08hr  (844) embryo 08-10hr  (513) embryo 10-12hr  (274) embryo 12-14hr  (225) embryo 14-16hr  143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr  (165) white prepupae 24hr  (303) pupae 2d postWPP  136 pupae 3d postWPP    77 pupae 4d postWPP  105 adult male 01day  124 adult male 05day  (201) adult male 30day  (187) adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr  (2509) embryo 04-06hr  1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr    2509 embryo 04-06hr    1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    193 embryo 02-04hr    2509 embryo 04-06hr    1904 embryo 06-08hr    844 embryo 08-10hr    513 embryo 10-12hr    274 embryo 12-14hr    225 embryo 14-16hr    143 embryo 16-18hr    91 embryo 18-20hr    82 embryo 20-22hr    38 embryo 22-24hr    45 larva L1    22 larva L2    7 larva L3 12hr old    34 larva L3 puffstage 1-2    45 larva L3 puffstage 3-6    69 larva L3 puffstage 7-9    92 white prepupae new    95 white prepupae 12hr    165 white prepupae 24hr    303 pupae 2d postWPP    136 pupae 3d postWPP    77 pupae 4d postWPP    105 adult male 01day    124 adult male 05day    201 adult male 30day    187 adult female 01day    44 adult female 05day    24 adult female 30day    31 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0004956    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0004956 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0004956 expression level Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0004956 expression level Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    30.65 Larval Midgut    0.9 Larval Hindgut    2.6 Larval Malpighian Tubules    1 Larval Fat Body    1.5 Larval Salivary Gland    2.8 Larval Trachea    1.15 Larval Carcass    7.125 Adult Head    2.5 Adult Eye    0.625 Adult Brain    2 Adult Thoracic-Abdominal Ganglion    2 Adult Crop    2.8 Adult Midgut    1.1 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    4.8 Adult Salivary Gland    8.9 Adult Heart    0.45 Adult VirginFemale Spermatheca    1 Adult InseminatedFemale Spermatheca    4.3 Adult Ovary    2.6 Adult Testis    6.6 Adult Male Accessory Gland    2.3 Adult Carcass    5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.5   NA  Eye    0.625   NA  Brain    2   30.65  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2   NA  Crop    2.8   0.9  Midgut    1.1   2.6  Hindgut    0.8   1  Malpighian Tubules    2.6   1.5  Fat Body    4.8   2.8  Salivary Gland    8.9   NA  Heart    0.45   1.15  Trachea    NA   NA  VirginFemale Spermatheca    1   NA  InseminatedFemale Spermatheca    4.3   NA  Ovary    2.6   NA  Testis    6.6   NA  Male Accessory Gland    2.3   7.125  Carcass    5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004956 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5993-RA;CG17377-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage osd4-2 osupd-1 osupd-2 lethal | embryonic stage | recessive osupd-3 osupd-4 lethal | pupal stage osGMR.PB lethal | recessive osUE69 osupd-3 osupd-4 semi-lethal | embryonic stage, with Df(3L)ED4238, Scer\GAL4GMR.PF osScer\UAS.cCa viable oso ossisC-1 ossisC-2 ossisC-3 ossisC-4 osupd-1 osupd-2 viable, with Scer\GAL4pnr-MD237 osGD1158 viable | reduced ossisC-5 Sterility Allele female sterile ossisC-5 male sterile osbdw osGMR.PB Other Phenotypes Allele cell shape defective | extended germ band stage osupd-4 hyperplasia, with Scer\GAL4C587 osScer\UAS.cZa increased cell number osGMR.PB increased cell number, with Scer\GAL4GMR.PF osScer\UAS.cZa increased cell number | somatic clone, with Scer\GAL4esg-NP5130 osScer\UAS.cZa memory defective | adult stage | RU486 conditional, with Scer\GAL4Mef2.247.Switch osNIG.5993R mitotic cell cycle defective | somatic clone, with Scer\GAL4esg-NP5130 osScer\UAS.cZa planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Act5C.PI osScer\UAS.cZa planar polarity defective | recessive | somatic clone osupd-4 planar polarity defective | somatic clone, with Scer\GAL430A osScer\UAS.cZa size defective, with Scer\GAL4ey.PH osScer\UAS.cZa size defective, with Scer\GAL4GMR.PU osScer\UAS.cZa visible os1 osGMR.PB oss ossisC-5 osunspecified osupd-3 osupd-4 visible, with Scer\GAL4bi-omb-Gal4 osScer\UAS.cZa visible, with Scer\GAL4dpp.blk1 osScer\UAS.cZa visible, with Scer\GAL4elav.PLu osScer\UAS.cZa visible, with Scer\GAL4ey.PH osScer\UAS.cZa visible, with Scer\GAL4GMR.PF osScer\UAS.cCa osScer\UAS.cZa visible (with Df(1)os1A2) osunspecified visible (with os1) osUE69 visible (with osUE69) os1 visible | recessive oso osupd-3 osupd-4 visible | somatic clone osd4-2 Phenotype manifest in Allele abdominal segment 4 osupd-1 osupd-2 abdominal segment 5 osupd-1 osupd-2 abdominal segment 6 osupd-1 osupd-2 abdominal segment 7 osupd-1 osupd-2 abdominal segment 8 osupd-1 osupd-2 adult abdominal segment osUE69 amnioserosa, with Scer\GAL4da.G32 osScer\UAS.cZa border follicle cell ossisC-5 osupd-4 border follicle cell, with Scer\GAL4c306 osScer\UAS.cZa border follicle cell, with Scer\GAL4slbo.2.6 osScer\UAS.cZa border follicle cell, with Scer\GAL4upd osGD1158 border follicle cell, with Scer\GAL4upd-E132 osScer\UAS.cZa border follicle cell (with ossisC-5) osupd-4 border follicle cell (with osupd-4) ossisC-5 border follicle cell | cell non-autonomous | ectopic | somatic clone, with Scer\GAL4Act5C.PP osScer\UAS.cZa border follicle cell | ectopic, with Scer\GAL4c306 osScer\UAS.cZa border follicle cell | ectopic, with Scer\GAL4slbo.2.6 osScer\UAS.cZa border follicle cell | ectopic | somatic clone, with Scer\GAL4Act5C.PI osScer\UAS.cCa osTM.Scer\UAS border follicle cell | somatic clone osupd-4 border follicle cell | supernumerary, with Scer\GAL4slbo.2.6 osScer\UAS.cZa centripetally migrating follicle cell | ectopic | somatic clone, with Scer\GAL4Act5C.PP osScer\UAS.cZa cuticle & adult external head, with Scer\GAL4ey.PH osScer\UAS.cCa cyst cell | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa cyst progenitor cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa cyst progenitor cell | supernumerary, with Scer\GAL4Act5C.PP osScer\UAS.cZa cyst progenitor cell | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa denticle belt & abdominal segment 4 osUE69 denticle belt & abdominal segment 5 osUE69 ectoderm | extended germ band stage osupd-4 egg chamber oshs.PM embryonic/larval cuticle osupd-1 osupd-2 embryonic/larval proventriculus osupd-3 embryonic abdominal segment 4 osupd-3 osupd-4 embryonic abdominal segment 5 osupd-3 osupd-4 embryonic abdominal segment 8 osUE69 osupd-3 embryonic head, with Scer\GAL4h-1J3 osScer\UAS.cZa embryonic hindgut, with Df(1)os1A2, Scer\GAL4byn-Gal4 osScer\UAS.cZa embryonic hindgut, with Scer\GAL4byn-Gal4 osScer\UAS.cZa embryonic mesothoracic segment osUE69 embryonic metathoracic segment osUE69 osupd-3 embryonic segment osUE69 escort stem cell | supernumerary, with Scer\GAL4C587 osScer\UAS.cZa extended germ band embryo, with Scer\GAL4da.G32 osScer\UAS.cZa eye os1 osGMR.PB oss osunspecified eye, with Scer\GAL4bi-omb-Gal4 osScer\UAS.cZa eye, with Scer\GAL4dpp.blk1 osScer\UAS.cZa eye, with Scer\GAL4elav.PLu osScer\UAS.cZa eye, with Scer\GAL4ey.PH osScer\UAS.cCa osScer\UAS.cZa eye, with Scer\GAL4GMR.PF osScer\UAS.cCa osScer\UAS.cZa eye, with Scer\GAL4GMR.PU osScer\UAS.cZa eye (with Df(1)os1A2) osunspecified eye (with os1) osUE69 eye (with osUE69) os1 eye | dorsal, with Scer\GAL430A osScer\UAS.cZa eye | somatic clone osd4-2 osupd-4 eye | ventral, with Scer\GAL430A osScer\UAS.cZa eye-antennal disc osGMR.PB eye disc osGMR.PB eye disc, with Scer\GAL4GMR.PF osScer\UAS.cCa eye disc | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4Act5C.PI osScer\UAS.cZa eye disc | third instar larval stage os1 eye disc | third instar larval stage, with Scer\GAL4dpp.blk1 osScer\UAS.cZa eye disc | third instar larval stage, with Scer\GAL4ey.PH osScer\UAS.cZa eye disc anterior to the morphogenetic furrow os1 eye disc anterior to the morphogenetic furrow, with Scer\GAL4GMR.PF osScer\UAS.cZa female germline stem cell | supernumerary, with Scer\GAL4C587 osScer\UAS.cZa germarium, with Scer\GAL4C587 osScer\UAS.cZa germline cell | embryonic stage, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa germline cyst | supernumerary, with Scer\GAL4C587 osScer\UAS.cZa germline stem cell, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa germline stem cell | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cCa gonad | ectopic & embryo osupd-4 interfollicle cell, with Scer\GAL4neur-P72 osScer\UAS.cCa interfollicle cell | supernumerary oshs.PM intestinal stem cell | somatic clone, with Scer\GAL4esg-NP5130 osScer\UAS.cZa larval head osupd-1 osupd-2 larval head | embryonic stage osUE69 male germline stem cell | supernumerary, with Scer\GAL4Act5C.PP osScer\UAS.cZa male germline stem cell | supernumerary, with Scer\GAL4nos.PG osScer\UAS.cCa male germline stem cell | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa mesothoracic segment osupd-1 osupd-2 morphogenetic furrow, with Scer\GAL4ey.PH osScer\UAS.cCa ommatidium os1 osGMR.PB ommatidium, with Scer\GAL430A osScer\UAS.cZa ommatidium, with Scer\GAL4GMR.PF osScer\UAS.cCa ommatidium (with os1) osUE69 ommatidium (with osUE69) os1 ommatidium | somatic clone osupd-4 ommatidium | somatic clone, with Scer\GAL4Act5C.PI osScer\UAS.cZa ommatidium | supernumerary, with Scer\GAL4GMR.PF osScer\UAS.cCa osScer\UAS.cZa oocyte oshs.PM oocyte associated follicle cell | somatic clone, with Scer\GAL4Act5C.PP osScer\UAS.cZa ovariole, with Scer\GAL4C587 osScer\UAS.cZa photoreceptor cell R8 | supernumerary, with Scer\GAL4GMR.PF osScer\UAS.cZa polar follicle cell oshs.PM pole cell | ectopic, with Scer\GAL4elav-C155 osScer\UAS.cZa pole cell | ectopic, with Scer\GAL4prd.RG1 osScer\UAS.cZa pole cell | ectopic, with Scer\GAL4twi.PG osScer\UAS.cZa primary gonial cell | supernumerary, with Scer\GAL4Act5C.PP osScer\UAS.cZa primary gonial cell | supernumerary, with Scer\GAL4nos.PG osScer\UAS.cCa primary gonial cell | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa round stem cell fusome | supernumerary, with Scer\GAL4Act5C.PP osScer\UAS.cZa round stem cell fusome | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa spermatogonium | supernumerary, with Scer\GAL4Act5C.PP osScer\UAS.cZa spermatogonium | supernumerary, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa stem cell fusome, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cZa tergite ossisC-5 testis, with Scer\GAL4nos.PG osScer\UAS.cCa testis, with Scer\GAL4nos.UTR.T:Hsim\VP16 osScer\UAS.cCa osScer\UAS.cZa wing oso osunspecified wing, with Scer\GAL4Bx-MS1096 osScer\UAS.T:Avic\GFP-EGFP
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of os Class Mutagen Stocks Known lesion oss spontaneous 16 -- oso X ray 8 -- os1 X ray 3 -- osupd-1 ethyl methanesulfonate 2 -- osupd-4 loss of function allele ethyl methanesulfonate 2 Yes os50a spontaneous 0 -- os54 0 -- osbdw X ray 0 -- osd4-2 0 Yes oss:sisC-1 recombination 0 -- ossisC-1 loss of function allele 0 Yes ossisC-2 0 Yes ossisC-3 0 Yes ossisC-4 0 Yes ossisC-5 0 Yes osUE69 gamma ray 0 -- osunspecified 0 -- osupd-2 ethyl methanesulfonate 0 -- osupd-3 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 20 )
For All Alleles Carried on Transgenic Constructs Show
Allele of os Class Mutagen Stocks Known lesion osGD1158 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes osHMS00545 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes osJF03149 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes osAct5C.PB in vitro construct - regulatory fusion 0 Yes osAct5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes osAct5C.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes osfl.cHa in vitro construct 0 Yes osGMR.PB in vitro construct - regulatory fusion 0 Yes oshs.PM in vitro construct - regulatory fusion 0 Yes osMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes osNIG.5993R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes osScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes osScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes osScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ost10 in vitro construct - genomic fragment 0 Yes ost4.8 in vitro construct - genomic fragment 0 Yes ost5.8 in vitro construct - genomic fragment 0 Yes osT:Ivir\HA1 in vitro construct - coding region fusion 0 Yes osTM.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes osΔss in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)BSC352 (Christensen and Cook, 2007.10.29) Df(1)BSC716 (Christensen et al., 2008.12.28) Df(1)N19 (Eberl et al., 1992, Harbecke and Lengyel, 1995) Df(1)os1A2 (Agaisse et al., 2003, Eberl et al., 1992, Hombria et al., 2005) Df(1)osUE69 (Harrison et al., 1998, Eberl et al., 1992, Hombria et al., 2005) In(1)sisC5 (Sefton et al., 1997)
Duplicated in	Dp(1;1)IMNB-8   Dp(1;1)MNB-8   Dp(1;1)NB-8   Dp(1;1)NBB-8   Dp(1;3)DC344 (Popodi et al., 2010-) Dp(1;3)DC345 (Popodi et al., 2010-) Dp(1;3)JC153 (Aguilera et al., 2000) Dp(1;3)MNB-8
Not disrupted in	Df(1)274 (Patterson, 1932) Df(1)N19 (Craymer and Roy, 1980) In(1)ClLbbDfR   In(1)ClLy4R   In(1)y4Lsc4R   Tp(1;2)sn+72d (Wieschaus et al., 1984)
Not duplicated in	Dp(1;3)126   Dp(1;f)100 (Morgan, 1938) In(1)bbDfLClR
Partially disrupted in	Df(1)os4-51-1 (Harrison et al., 1998) Df(1)os109 (Harrison et al., 1998) Df(1)osc18 (Harrison et al., 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1158} NA P{TRiP.HMS00545} NA P{TRiP.JF03149} NA P{UAS-os.C} NA P{UAS-os.TM} NA P{UAS-os.Z} NA P{UAS-upd.EGFP} NA heat-shock construct P{hs-os.M} NA characterization construct P{GMR-upd.B} NA P{NIG.5993R} NA P{sisC.4.8} NA P{sisC.5.8} NA P{sisC.10} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}ossisC-1 NA insertion of mobile activating element P{Mae-UAS.6.11}B1513B1513 NA
Gene Ontology: Function, Process & Cellular Component ( 29 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
apical constriction inferred from mutant phenotype (Bertet et al., 2009) border follicle cell migration inferred from mutant phenotype (Xi et al., 2003) compound eye morphogenesis inferred from mutant phenotype (Tsai and Sun, 2004) eye-antennal disc morphogenesis inferred from mutant phenotype (Ekas et al., 2006) foregut morphogenesis inferred from mutant phenotype (Josten et al., 2004) hindgut morphogenesis inferred from mutant phenotype (Johansen et al., 2003) long-term memory inferred from mutant phenotype (Copf et al., 2011) mediolateral intercalation inferred from mutant phenotype (Bertet et al., 2009) ovarian follicle cell development inferred from mutant phenotype (Xi et al., 2003, Medioni and Noselli, 2005) paracrine signaling inferred from direct assay (Wright et al., 2011) positive regulation of JAK-STAT cascade inferred from direct assay (Hombria et al., 2005, Wright et al., 2011) inferred from genetic interaction with dome (Wright et al., 2011) inferred from genetic interaction with hop (Wright et al., 2011) inferred from genetic interaction with Ptp61F (Wright et al., 2011) inferred from genetic interaction with Socs36E (Wright et al., 2011) inferred from genetic interaction with Stat92E (Wright et al., 2011) inferred from mutant phenotype (Wright et al., 2011) primary sex determination inferred from mutant phenotype (Jinks et al., 2000) regulation of embryonic cell shape inferred from mutant phenotype (Bertet et al., 2009) stem cell division inferred from mutant phenotype (Kiger et al., 2001, Tulina and Matunis, 2001)
Cellular Component
CV term Evidence References
apical part of cell inferred from direct assay (Van De Bor et al., 2011) extracellular space inferred from direct assay (Van De Bor et al., 2011)
Terms Based on Predictions or Assertions ( 16 terms )
Molecular Function
CV term Evidence References
cytokine activity traceable author statement (Agaisse and Perrimon, 2004) morphogen activity non-traceable author statement (Lopez-Schier, 2003) receptor binding non-traceable author statement (Luo and Dearolf, 2001) traceable author statement (Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004)
Biological Process
CV term Evidence References
blastoderm segmentation traceable author statement (Luo and Dearolf, 2001) border follicle cell migration traceable author statement (Castelli-Gair Hombria and Brown, 2002) defense response non-traceable author statement (Lemaitre, 2000.12.20) embryonic development via the syncytial blastoderm traceable author statement (Agaisse and Perrimon, 2004) germ-line stem cell division traceable author statement (Lin, 2002) JAK-STAT cascade non-traceable author statement (Sefton, 2000.2.4, Lemaitre, 2000.12.20) traceable author statement (Jinks et al., 2000, Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004) primary sex determination non-traceable author statement (Sefton, 2000.2.4) sex determination non-traceable author statement (Luo and Dearolf, 2001) sex determination, establishment of X:A ratio non-traceable author statement (Schutt and Nothiger, 2000) somatic stem cell division traceable author statement (Lin, 2002) stem cell division traceable author statement (Castelli-Gair Hombria and Brown, 2002)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Morey and Harrison, 1998, Sefton, 2000.2.4, Lemaitre, 2000.12.20) traceable author statement (Jinks et al., 2000, Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004, Lopez-Schier, 2003) proteinaceous extracellular matrix traceable author statement (Jinks et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions os allele Gene References os1 eyg (Chao et al., 2004) Su(var)2-10 (Betz et al., 2001) osGMR.PB BRWD3 (Muller et al., 2005) crb (Bach et al., 2003) CtBP (Bach et al., 2003) D (Bach et al., 2003) Dad (Bach et al., 2003) dome (Bach et al., 2003) dpp (Bach et al., 2003) esg (Bach et al., 2003) gl (Bach et al., 2003) hdc (Bach et al., 2003) hh (Bach et al., 2003) His2Av (Bach et al., 2003) hop (Bach et al., 2003) kto (Bach et al., 2003) l(1)3Ag (Bach et al., 2003) Mad (Bach et al., 2003) pie (Bach et al., 2003) put (Bach et al., 2003) px (Bach et al., 2003) sax (Bach et al., 2003) Stat92E (Bach et al., 2003, Muller et al., 2005) tkv (Bach et al., 2003) osScer\UAS.cCa CycD (Chen et al., 2003) dome (Chen et al., 2002) hop (Chen et al., 2002) osScer\UAS.cZa dome (Brown et al., 2001, Ghiglione et al., 2002) drm (Johansen et al., 2003) eyg (Chao et al., 2004) hop (Kiger et al., 2001, Bach et al., 2003) ossisC-1 sisA (Sefton et al., 2000) ossisC-5 sisA (Sefton et al., 2000) ost4.8 sisA (Sefton et al., 2000) ost5.8 sisA (Sefton et al., 2000) ost10 sisA (Sefton et al., 2000) osunspecified dome (Bach et al., 2003) dpp (Bach et al., 2003) E(bx) (Badenhorst et al., 2002) Socs36E (Bach et al., 2003) tkv (Bach et al., 2003) osupd-3 hop (McGregor et al., 2002) osupd-4 hop (Harrison et al., 1998, McGregor et al., 2002) unspecified Brd (Mukherjee et al., 2006) bun (Mukherjee et al., 2006) cdc2 (Mukherjee et al., 2006) Cdk4 (Mukherjee et al., 2006, Chen et al., 2003) CG4306 (Mukherjee et al., 2006) CG17574 (Mukherjee et al., 2006) CG32982 (Mukherjee et al., 2006) Cip4 (Mukherjee et al., 2006) clu (Mukherjee et al., 2006) cpo (Mukherjee et al., 2006) Csk (Read et al., 2004) CtBP (Mukherjee et al., 2006) CycA (Mukherjee et al., 2006) dap (Mukherjee et al., 2006) Dl (Mukherjee et al., 2006) dm (Mukherjee et al., 2006) jim (Mukherjee et al., 2006) Lamp1 (Mukherjee et al., 2006) mir-14 (Mukherjee et al., 2006) Mob2 (Mukherjee et al., 2006) mthl8 (Mukherjee et al., 2006) N (Mukherjee et al., 2006) NFAT (Mukherjee et al., 2006) pAbp (Mukherjee et al., 2006) poly (Mukherjee et al., 2006) Rac1 (Silver, 2005) RpII140 (Parkhurst and Ish-Horowicz, 1991) rux (Mukherjee et al., 2006) Sodh-2 (Mukherjee et al., 2006) spri (Mukherjee et al., 2006) Ssdp (Mukherjee et al., 2006) Stat92E (Mukherjee et al., 2006, Silver and Montell, 2001, Read et al., 2004) Tcp-1η (Mukherjee et al., 2006) Ten-m (Mukherjee et al., 2006) trbl (Mukherjee et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59130 DroID - A comprehensive database of gene and protein interactions. • FBgn0004956 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32813
Orthologs
Genome-wide drosophilid orthologs	Dana\Om(1E) Dere\GG18131 Dgri\GH17790 Dmoj\GI15131 Dper\GL27044 Dpse\GA19283 Dsec\GM22824 Dsim\GD15648 Dvir\GJ18988 Dwil\GK19868 Dyak\GE15539
Curated drosophilid orthologs	Dana\Om(1E) (Morey and Harrison, 1998) Dpse\GA19283   Dsim\upd (Hombria et al., 2005) Dvir\upd (Hombria et al., 2005) Dyak\upd (Hombria et al., 2005)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233112 FBgn0221866 FBgn0187310 FBgn0177694 FBgn0079280 FBgn0164625 FBgn0137881 FBgn0125260 FBgn0110347 FBgn0012123
Stocks & Reagents
Stocks Listed in FlyBase ( 34 )
Bloomington	78 oso 79 oss 667 oss; tet1 4767 w1 osupd-4/FM7a 4752 ff1 Sh14 oss/FM6 28722 y1 v1; P{TRiP.JF03149}attP2 4740 por15175 oss/FM6, w1
Kyoto	105718 oso 105719 oss 107864 w1 osupd-4/FM7a 107859 ff1 Sh14 oss/FM6
VDRC	v3282 w1118; P{GD1158}v3282
	More stocks available...
Genomic Clones ( 2 )
	BACR10E05 BACR32F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT13666
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT23111
Other clones	101441 EK228313
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0004956 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32813
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: os CG5993 (Li, 1999.11)
Source for database merge of	Source for merge of: os sisC (Sefton et al., 1998)
Additional comments	"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3"). (Wang, 2005) Originally considered two separate loci, od: outstretched and sy: small eye, Muller proposed a single gene based on the recovery of a mutant with both phenotypes, which was not resolvable into two components by recombination as well as on the failure to recover recombinants between od and sy in transheterozygotes (Verderosa and Muller, 1954).
Other Comments
	Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) dome (Hombria et al., 2005) os protein, secreted by the polar follicle cells, may act as a morphogen to specify anterior-posterior pattern in the ovarian follicle cells. (Xi et al., 2003) os is required for self-renewal of male germ line stem cells and somatic cyst progenitor cells. (Tulina and Matunis, 2001) Overexpression of os in the testis results in expansion of both the germ line stem cell and somatic cyst progenitor cell populations. (Tulina and Matunis, 2001) os acts as an X-linked signal element in sex determination. (Sefton et al., 2000) os is necessary to determine the position of the eye equator via regulation of mirr. (Zeidler et al., 1999) A localised source of os protein, which is present at the midline of the developing eye, is capable of activating the JAK/STAT pathway over long distances. (Zeidler et al., 1999) os protein can activate the JAK signaling pathway. (Harrison et al., 1998) γ ray induced loss of function mutations suppress male-lethal duplications of numerator elements. (Cline, 1993) The os gene has been studied as part of a genetic and developmental study of polytene section 17 of the X chromosome. A duplication of this region, fcl+Y, has been constructed to allow mutagenesis screens and complementation analyses of the region. (Eberl et al., 1992) Mutations in zygotic cardinal gene os interact with RpII140wimp. (Parkhurst and Ish-Horowicz, 1991) os mutants display defects predominantly in mesothorax and fifth row, head defects and eighth segment defects. (Wieschaus et al., 1984)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080356 NM_001103545 RefSeq (Proteins) • NP_525095 NP_001097015 DDBJ / EMBL / GenBank • AAC69620 AAF48823 AAF61221 AAM29254 ABW09444 AF072823 AF231684 AY113249 BF499160 DQ327779 Entrez Gene - A searchable database of RefSeq genes. • 32813 UniProtKB/TrEMBL • O96525 Q8MZC7 Q9VWW4
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 59130 DroID - A comprehensive database of gene and protein interactions. • FBgn0004956 DRSC - Results from RNAi screens. • FBgn0004956 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0004956 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5993-RA;CG17377-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0004956 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205653 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32813 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/outstrh1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32813 modMine - Data generated by the modENCODE project. • FBgn0004956 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0233112 FBgn0221866 FBgn0187310 FBgn0177694 FBgn0079280 FBgn0164625 FBgn0137881 FBgn0125260 FBgn0110347 FBgn0012123
Synonyms & Secondary IDs ( 33 )
Reported As
Symbol Synonym	bdw   CG5993 (Klebes et al., 2005, Grieder et al., 2007, Perkins et al., 2009, Ni et al., 2010.12.1, Wright et al., 2011) l(1)YC43   l(1)YM55   od (University of Buenos Aires, 1951, ) odsy   os (Wang and Harrison, 2007, Herz et al., 2006, Christensen and Cook, 2007.10.29, Wang and Harrison, 2008, Sturgill et al., 2007, Grieder et al., 2007, Lindsley and Zimm, 1992, Liu and Lehmann, 2008, Christensen et al., 2008.12.28, López-Onieva et al., 2008, Almudi et al., 2009, Liang et al., 2008, Moeller et al., 2005, Manak et al., 2006, Bertet et al., 2009, Wang and Huang, 2009, Gutierrez-Aviño et al., 2009, Popodi et al., 2010-, Jacques et al., 2009, Ekas et al., 2010) Os (Terry et al., 2006, Payne and Braun, 2006, Classen et al., 2009) OS (Arbouzova and Zeidler, 2006) sisC (Zeidler et al., 2000, Pomiankowski et al., 2004, Sefton et al., 2000, Schutt and Nothiger, 2000, Sefton et al., 1998, Cline, 1993, Avila and Erickson, 2007, Liang et al., 2008) sis-c (Calhoun et al., 2004, Pettus and Nagoshi, 1998) sis-C (Fisher and Caudy, 1998) sy (Patterson, 1932, ) unp (Badenhorst et al., 2002) upa (Martinez Arias, 1993) Upd (Zhang, 2005, Baeg et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Read et al., 2004, Muller et al., 2005, Gilboa and Lehmann, 2004, Agaisse et al., 2003, Hultmark and Ekengren, 2003, Zeidler et al., 2005, Sexton et al., 2004, Mukherjee and Zeidler, 2003, Arbouzova et al., 2003, Fuchs et al., 2004, Oh et al., 2004, Ekas and Bach, 2004, Denef and Schupbach, 2003, Wallenfang and DiNardo, 2003, Xi et al., 2003, Kisseleva et al., 2002, Tulina and Matunis, 2002, Xi and Harrison, 2002, Tulina and Matunis, 2001, Zeidler et al., 1999, Zeidler et al., 1999, Blair, 1999, Wong et al., 2006, Sexton et al., 2006, Bina and Zeidler, 2006, Yasugi et al., 2007, Pei and Harrison, 2007, Giebel and Wodarz, 2006, Bartscherer et al., 2006, Fuller and Spradling, 2007, Tolwinski, 2007, Nurminsky, 2007, Luque and Milan, 2007, Moberg et al., 2005, Yamashita et al., 2005, Yamashita and Fuller, 2008, Tsai et al., 2007, Vaccari and Bilder, 2005, Thompson et al., 2005, Akbar et al., 2009, Vaccari et al., 2009, Sheng et al., 2009, Jiang et al., 2009, Rivas et al., 2008, Gilbert et al., 2009, Bina et al., 2010, Lin et al., 2010, Van De Bor et al., 2011, Ren et al., 2010, Jiang et al., 2011, Wright et al., 2011) upd (Grieder et al., 2005, Gilbert et al., 2005, Muller, 2005, Li et al., 2003, Zeidler et al., 2000, Wang, 2005, Wang et al., 2005, Tsai and Sun, 2005, Sexton et al., 2005, Reynolds-Kenneally and Mlodzik, 2005, Liu and Sun, 2005, Ekas and Bach, 2005, Davies et al., 2005, Agaisse and Perrimon, 2004, Josten et al., 2004, Starz-Gaiano and Montell, 2004, Bach et al., 2003, Yamashita et al., 2004, Tsai and Sun, 2004, Johansen et al., 2003, Johansen et al., 2003, Chen et al., 2003, Brown et al., 2003, Xi et al., 2003, Lin, 2002, Hou et al., 2002, Zhao and Garbers, 2002, Adler, 2002, Maines et al., 2003, Tulina et al., 2003, Karsten et al., 2002, Johansen et al., 2003, Ghiglione et al., 2002, Grammont and Irvine, 2002, Castelli-Gair Hombria and Brown, 2002, Green et al., 2002, Harrison et al., 2002, Chen et al., 2002, Bach and Perrimon, 2002, Johansen et al., 2002, Harrison et al., 2002, Bach and Perrimon, 2002, Zheng and Hou, 2002, Jones et al., 2001, Beccari et al., 2002, Chen et al., 2002, McGregor et al., 2002, Lengyel and Iwaki, 2002, Kiger et al., 2001, Spradling et al., 2001, Iwaki et al., 2001, Brown et al., 2001, Silver and Montell, 2001, Luo and Dearolf, 2001, Johansen et al., 2001, Johansen et al., 2001, Xi and Harrison, 2001, Tsai and Sun, 2001, Jinks et al., 2000, Morey et al., 2000, Xi and Harrison, 2000, Bach et al., 2000, Dearolf, 1999, Tsai and Sun, 1999, Zeidler et al., 1999, Savant-Bhonsale et al., 1999, Zeidler et al., 1999, Morey and Harrison, 1999, Keating and Harrison, 1999, Bach et al., 1999, Harrison et al., 1998, Mathey-Prevot et al., 1998, Sefton et al., 1998, Morey and Harrison, 1998, Sefton et al., 1997, Harrison and Perrimon, 1997, McCoon and Gilman, 1997, Cline and Meyer, 1996, Harbecke and Lengyel, 1995, Klingler and Gergen, 1993, Parkhurst and Ish-Horowicz, 1991, Perrimon et al., 1989, DiNardo and O'Farrell, 1987, Carroll and Scott, 1986, Wieschaus et al., 1984, Zheng et al., 2006, Singh et al., 2006, Herz, 2006, Ekas et al., 2006, DEVERGNE and NOSELLI, 2006, Ekas et al., 2006, Decotto and Spradling, 2005, Sexton and Harrison, 2007, Wang et al., 2007, Wang and Harrison, 2007, Flaherty et al., 2007, Tsai et al., 2007, Keller, 2006, Arbouzova et al., 2006, Herz et al., 2006, Hombria et al., 2005, Mukherjee et al., 2006, Tsai and Sun, 2004, Copf et al., 2011, Parrott et al., 2011, Duong et al., 2008, Lovegrove et al., 2006, Bach et al., 2007, Wang et al., 2006, Singh et al., 2010, Yuva-Aydemir et al., 2011, Montell, 2006, Sexton and Harrison, 2008, Wang et al., 2008, Copf and Preat, 2008, Wang and Harrison, 2008, Assa-Kunik et al., 2007, Grieder et al., 2007, Brown et al., 2006, Ayala-Camargo et al., 2007, Wawersik et al., 2005, Voog et al., 2008, Wang et al., 2008, López-Onieva et al., 2008, Cinnamon et al., 2008, Yasugi et al., 2008, Tsai et al., 2007, Avila and Erickson, 2007, Furriols et al., 2007, Singh et al., 2006, Sotillos et al., 2008, Devergne et al., 2007, Rawlings et al., 2004, Almudi et al., 2009, Xie et al., 2005, Smith-Bolton et al., 2009, Flaherty et al., 2009, Cronin et al., 2009, Bertet et al., 2009, Sheng et al., 2009, Casper and Van Doren, 2009, Wang and Huang, 2009, Classen et al., 2009, Gutierrez-Aviño et al., 2009, Beebe et al., 2010, Sotillos et al., 2010, Flaherty et al., 2010, Goto et al., 2010, Leatherman and DiNardo, 2008, Ekas et al., 2010, Kallio et al., 2010, Mukherjee et al., 2005, Ngo et al., 2010, Gladstein et al., 2010, Feng et al., 2011, Pastor-Pareja et al., 2008, Zhai et al., 2010, Liu et al., 2010, Wright et al., 2011, Casper et al., 2011, Zheng et al., 2011) UPD (Silver and Montell, 2002, Scadden, 2006, Castelli-Gair Hombria, 2006, Arbouzova and Zeidler, 2006) upd1 (Krzemien et al., 2007) Upd1 (Devergne et al., 2007)
Name Synonym	bending-wings   Outstreched (Classen et al., 2009) outstretched (University of Buenos Aires, 1951, Kurusu et al., 2008, Avila and Erickson, 2007, Flaherty et al., 2009, Hill-Burns and Clark, 2009, Ekas et al., 2010) Outstretched (Leatherman and DiNardo, 2007) outstretched-smalleye   outstretched small eye (Lindsley and Zimm, 1992) sisterless c (Cline, 1993, ) small-eye (Morgan, 1938, ) unpaired (Kile et al., 2002, Wawersik et al., 2004, Rennebeck et al., 2002, Matunis and Tulina, 2001, Rennebeck and Harrison, 2001, Matunis and Tulina, 2001, Lemaitre, 2000.12.20, Williams, 2000, Zeidler and Perrimon, 2000, Mlodzik, 1999, Strutt and Strutt, 1999, Harrison et al., 1998, Hou and Perrimon, 1997, Torres et al., 2003, Agaisse and Perrimon, 2004, Starz-Gaiano and Montell, 2004, Johansen et al., 2001, Xi and Harrison, 2000, Harrison, 1998.6.17, Blair, 1999, Morey and Harrison, 1998, Martinez Arias, 1993, Carroll and Scott, 1986, Tsai et al., 2007, Maurange et al., 2006, Herz et al., 2006, Tsai and Sun, 2004, Bach et al., 2007, Casper and Van Doren, 2006, Wang et al., 2008, Lin, 2008, Ayala-Camargo et al., 2007, Tsai et al., 2007, Avila and Erickson, 2007, Singh et al., 2006, Cronin et al., 2009, Bertet et al., 2009, Gutierrez-Aviño et al., 2009, Beebe et al., 2010, Kallio et al., 2010, Zhai et al., 2010) Unpaired (Solnica-Krezel and Eaton, 2003, Lopez-Schier, 2003, Rorth, 2002, Wasserman and DiNardo, 2001, Morey et al., 2001, Harrison and Morey, 2000, Wallenfang and DiNardo, 2003, Ekas et al., 2006, Scadden, 2006, Yasugi et al., 2007, Ayala et al., 2007, Seydoux and Braun, 2006, Fuller and Spradling, 2007, Tountas and Fortini, 2007, Luque and Milan, 2007, Montell, 2006, Morrison and Kimble, 2006, Yasugi et al., 2008, Sotillos et al., 2008, Smith-Bolton et al., 2009, Vaccari et al., 2009, Classen et al., 2009, Bina et al., 2010) unpaired 1 (Kula-Eversole and Hatini, 2007) Unpaired 1 (Devergne et al., 2007) Unpaired/Out-stretched (Payne and Braun, 2006)
Secondary FlyBase IDs
	FBgn0003012 FBgn0003956 FBgn0016985
References ( 316 )
Generate a list of	All references relating to this gene ( 316 )
List References by type	Research paper  ( 151 ) Supplementary material  ( 6 ) Review  ( 50 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 87 ) FlyBase analysis  ( 1 ) Conference report  ( 4 ) DNA/RNA sequence record  ( 2 ) Book  ( 4 ) Curated genome annotation  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 25 )
	Casper et al., 2011, Development 138(16): 3357--3366 no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females. [FBrf0214565] Copf et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(19): 8059--8064 Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. [FBrf0213703] Feng et al., 2011, EMBO Rep. 12(2): 157--163 Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. [FBrf0214189] Jiang et al., 2011, Cell Stem Cell 8(1): 84--95 EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila. [FBrf0212694] Parrott et al., 2011, PLoS ONE 6(9): e25087 Nucleoporin98-96 Function Is Required for Transit Amplification Divisions in the Germ Line of Drosophila melanogaster. [FBrf0216255] Van De Bor et al., 2011, Development 138(7): 1383--1393 Asymmetric localisation of cytokine mRNA is essential for JAK/STAT activation during cell invasiveness. [FBrf0213214] Willecke et al., 2011, Oncogene 30(39): 4067--4074 Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. [FBrf0216281] Wright et al., 2011, Cell. Signal. 23(5): 920--927 Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. [FBrf0213113] Yuva-Aydemir et al., 2011, J. Neurosci. 31(19): 7005--7015 Spinster Controls Dpp Signaling during Glial Migration in the Drosophila Eye. [FBrf0213705] Zheng et al., 2011, Dev. Biol. 357(1): 202--210 magu is required for germline stem cell self-renewal through BMP signaling in the Drosophila testis. [FBrf0214645] Beebe et al., 2010, Dev. Biol. 338(1): 28--37 JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. [FBrf0209772] Bina et al., 2010, EMBO Rep. 11(3): 201--207 Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation. [FBrf0210131] Ekas et al., 2010, Dev. Biol. 344(2): 621--636 Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. [FBrf0211400] Flaherty et al., 2010, Dev. Cell 18(4): 556--568 chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. [FBrf0210682] Gladstein et al., 2010, PLoS Genet. 6(7): e1001041 Requirement of male-specific dosage compensation in Drosophila females-implications of early X chromosome gene expression. [FBrf0211448] Goto et al., 2010, J. Biol. Chem. 285(21): 15731--15738 Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway. [FBrf0210770] Kallio et al., 2010, FASEB J. 24(11): 4467--4479 Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. [FBrf0212202] Karpowicz et al., 2010, Development 137(24): 4135--4145 The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383] Lin et al., 2010, J. Mol. Cell. Biol. 2(1): 37--49 Paracrine Unpaired Signaling through the JAK/STAT Pathway Controls Self-renewal and Lineage Differentiation of Drosophila Intestinal Stem Cells. [FBrf0209721] Liu et al., 2010, J. Cell. Biochem. 109(5): 992--999 JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. [FBrf0210433] Ngo et al., 2010, Dev. Biol. 346(2): 284--295 Concomitant requirement for Notch and Jak/Stat signaling during neuro-epithelial differentiation in the Drosophila optic lobe. [FBrf0211910] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Singh et al., 2010, J. Cell. Physiol. 223(2): 500--510 Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. [FBrf0210092] Sotillos et al., 2010, Dev. Biol. 340(2): 571--582 An efficient approach to isolate STAT regulated enhancers uncovers STAT92E fundamental role in Drosophila tracheal development. [FBrf0210508] Zhai et al., 2010, Europ. J. Cell Biol. 89(2-3): 273--278 Cellular analysis of newly identified Hox downstream genes in Drosophila. [FBrf0209935] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...