Gene Dmel\os

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

os-PA

FBpp0074353

47.0

413

12.00

NP_525095

AAF48823

os-PB

FBpp0111760

47.0

413

12.00

NP_001097015

ABW09444

Additional Polypeptide Data & Comments

Reported size (kDa)

413 (aa); 47 (kD predicted)

Comments

External Data

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Crossreferences

Expression Data

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

organism | pair rule expression pattern

embryonic stage 6 -- 7

organism | segment polarity expression pattern

embryonic stage 9 -- 17

tracheal pit

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 5

organism | 20-80% egg length

organism | anterior & dorsal

embryonic stage 10 -- 11

organism | segmentally repeated & striped

embryonic stage 11

small intestine primordium

(Uddin et al., 2011)

embryonic stage 12 -- 14

embryonic small intestine

(Uddin et al., 2011)

embryonic stage 13

small intestine primordium

(Iwaki et al., 2001)

embryonic stage 13 -- 14

imaginal precursor

embryonic stage 14

ectoderm of pharynx

(Hombria et al., 2005)

ectoderm of hindgut

(Hombria et al., 2005)

Additional Descriptive Data

os transcripts become abundant shortly before cellularization at which time they are present in the trunk region and in an incomplete head stripe but not in the termini. At cellularization, the trunk region expression resolves into 7 stripes. In early gastrulation, 14 stripes appear. In later stages, expression is largely restricted to the tracheal pits.

Marker for

embryonic small intestine

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

os protein localizes to the extracellular matrix.

Marker for

Subcellular Localization (GO Cellular Component)

CV term

References

apical part of cell

inferred from direct assay

extracellular space

inferred from direct assay

(The modENCODE Consortium, 2010, Graveley et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		30.65
Larval Midgut		0.9
Larval Hindgut		2.6
Larval Malpighian Tubules		1
Larval Fat Body		1.5
Larval Salivary Gland		2.8
Larval Trachea		1.15
Larval Carcass		7.125
Adult Head		2.5
Adult Eye		0.625
Adult Brain		2
Adult Thoracic-Abdominal Ganglion		2
Adult Crop		2.8
Adult Midgut		1.1
Adult Hindgut		0.8
Adult Malpighian Tubules		2.6
Adult Fat Body		4.8
Adult Salivary Gland		8.9
Adult Heart		0.45
Adult VirginFemale Spermatheca		1
Adult InseminatedFemale Spermatheca		4.3
Adult Ovary		2.6
Adult Testis		6.6
Adult Male Accessory Gland		2.3
Adult Carcass		5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	2.5
NA	Eye	0.625
NA	Brain	2
30.65	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	2
NA	Crop	2.8
0.9	Midgut	1.1
2.6	Hindgut	0.8
1	Malpighian Tubules	2.6
1.5	Fat Body	4.8
2.8	Salivary Gland	8.9
NA	Heart	0.45
1.15	Trachea	NA
NA	VirginFemale Spermatheca	1
NA	InseminatedFemale Spermatheca	4.3
NA	Ovary	2.6
NA	Testis	6.6
NA	Male Accessory Gland	2.3
7.125	Carcass	5

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		7
central nervous system, larvae L3		2
central nervous system, pupae P8		0
head, virgin 1-day female		0
head, virgin 4-day female		0
head, virgin 20-day female		0
head, mated 1-day female		0
head, mated 4-day female		0
head, mated 20-day female		0
head, mated 1-day male		0
head, mated 4-day male		0
head, mated 20-day male		0
salivary gland, larvae L3 wandering		0
salivary gland, white prepupae		1
digestive system, larvae L3 wandering		0
digestive system, 1-day adult		0
digestive system, 4-day adult		0
digestive system, 20-day adult		0
fat body, larvae L3 wandering		0
fat body, white prepupae		2
fat body, pupae P8		2
carcass, larvae L3 wandering		1
carcass, 1-day adult		0
carcass, 4-day adult		0
carcass, 20-day adult		0
ovary, virgin 4-day female		0
ovary, mated 4-day female		0
testis, mated 4-day male		16
accessory gland, mated 4-day male		2
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		(28)
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		2
embryo 02-04hr		28
embryo 04-06hr		22
embryo 06-08hr		10
embryo 08-10hr		6
embryo 10-12hr		3
embryo 12-14hr		3
embryo 14-16hr		2
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		0
embryo 22-24hr		1
larva L1		0
larva L2		0
larva L3 12hr old		0
larva L3 puffstage 1-2		1
larva L3 puffstage 3-6		1
larva L3 puffstage 7-9		1
white prepupae new		1
white prepupae 12hr		2
white prepupae 24hr		4
pupae 2d postWPP		2
pupae 3d postWPP		1
pupae 4d postWPP		1
adult male 01day		2
adult male 05day		3
adult male 30day		2
adult female 01day		0
adult female 05day		0
adult female 30day		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		0
Schneider line 2 Sg4		0
embryonic 1182-4H		0
embryonic GM2		0
embryonic Kc167		0
embryonic S1		5
embryonic S3		0
leg disc CME L1		0
wing disc CME-W2		0
wing disc ML-DmD8		0
wing disc ML-DmD9		0
wing disc ML-DmD16-c3		0
wing disc ML-DmD21		0
wing disc ML-DmD32		0
haltere disc ML-DmD17-c3		0
eye-antennal disc ML-DmD11		0
antennal disc ML-DmD20-c5		0
mixed discs ML-DmD4-c1		0
CNS ML-DmBG1-c1		0
CNS ML-DmBG2-c2		0
tumorous blood cells mbn2		0
ovary fGS/OSS		0
ovary OSC		0
ovary OSS		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		1
cold shock, 4-day adult		1
heat shock, 4-day adult		1
Cadmium 50 mM 6 hrs, larvae L3		0
Cadmium 50 mM 12 hrs, larvae L3		0
Cadmium 50 mM 48 hrs, 4-day adult		1
Cadmium 100 mM 48 hrs, 4-day adult		2
Copper 0.5 mM 12 hrs, larvae L3		0
Copper 15 mM 48 hrs, 4-day adult		3
Zinc 5 mM 12 hrs, larvae L3		1
Zinc 4.5 mM 48 hrs, 4-day adult		3
Ethanol 2.5% 3 hrs, larvae L3		1
Ethanol 5% 3 hrs, larvae L3		0
Ethanol 10% 3 hrs, larvae L3		0
Caffeine 1.5 mg/ml 4 hrs, larvae L3		0
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		1
Caffeine 25 mg/ml 48 hrs, 4-day adult		1
Paraquat 5 mM 48 hrs, 4-day adult		2
Paraquat 10 mM 48 hrs, 4-day adult		2
Rotenone 2 μg 12 hrs, larvae L3		0
Rotenone 8 μg 12 hrs, larvae L3		0
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

External Data & Images

cell shape defective | extended germ band stage

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0004956

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG5993-RA;CG17377-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | embryonic stage

lethal | embryonic stage | recessive

lethal | pupal stage

os^GMR.PB

lethal | recessive

partially lethal - majority die | embryonic stage, with Df(3L)ED4238, Scer\GAL4^GMR.PF

os^Scer\UAS.cCa

viable

viable, with Scer\GAL4^pnr-MD237

os^GD1158

viable | reduced

os^sisC-5

Sterility

Allele

female sterile

os^sisC-5

male sterile

Other Phenotypes

Allele

os^upd-4

hyperplasia, with Scer\GAL4^C587

os^Scer\UAS.cZa

increased cell number

os^GMR.PB

increased cell number, with Scer\GAL4^GMR.PF

os^Scer\UAS.cZa

increased cell number | somatic clone, with Scer\GAL4^esg-NP5130

os^Scer\UAS.cZa

locomotor rhythm defective, with Scer\GAL4^mir-279.PC

os^NIG.5993R

locomotor rhythm defective, with Scer\GAL4^tim.PE

locomotor rhythm defective, with Scer\GAL4^tim.Scer\UAS

os^NIG.5993R

locomotor rhythm defective | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

os^Scer\UAS.cUa

memory defective | adult stage | RU486 conditional, with Scer\GAL4^{Mef2.247.Switch}

os^NIG.5993R

mitotic cell cycle defective | somatic clone, with Scer\GAL4^esg-NP5130

os^Scer\UAS.cZa

planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4^Act5C.PI

os^Scer\UAS.cZa

planar polarity defective | recessive | somatic clone

os^upd-4

planar polarity defective | somatic clone, with Scer\GAL4^30A

os^Scer\UAS.cZa

size defective, with Scer\GAL4^ey.PH

os^Scer\UAS.cZa

size defective, with Scer\GAL4^GMR.PU

os^Scer\UAS.cZa

visible

visible, with Scer\GAL4^bi-omb-Gal4

os^Scer\UAS.cZa

visible, with Scer\GAL4^dpp.blk1

os^Scer\UAS.cZa

visible, with Scer\GAL4^elav.PLu

os^Scer\UAS.cZa

visible, with Scer\GAL4^ey.PH

os^Scer\UAS.cZa

visible, with Scer\GAL4^GMR.PF

visible (with Df(1)os1A2)

os^unspecified

visible (with os¹)

os^UE69

visible (with os^UE69)

os¹

visible | recessive

visible | somatic clone

os^d4-2

Phenotype manifest in

Allele

adult abdominal segment

os^UE69

amnioserosa, with Scer\GAL4^da.G32

os^Scer\UAS.cZa

border follicle cell

border follicle cell, with Scer\GAL4^c306

os^Scer\UAS.cZa

border follicle cell, with Scer\GAL4^slbo.2.6

os^Scer\UAS.cZa

border follicle cell, with Scer\GAL4^upd

os^GD1158

border follicle cell, with Scer\GAL4^upd-E132

os^Scer\UAS.cZa

border follicle cell (with os^sisC-5)

os^upd-4

border follicle cell (with os^upd-4)

os^sisC-5

border follicle cell | cell non-autonomous | ectopic | somatic clone, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

border follicle cell | ectopic, with Scer\GAL4^c306

os^Scer\UAS.cZa

border follicle cell | ectopic, with Scer\GAL4^slbo.2.6

os^Scer\UAS.cZa

border follicle cell | ectopic | somatic clone, with Scer\GAL4^Act5C.PI

border follicle cell | somatic clone

os^upd-4

border follicle cell | supernumerary, with Scer\GAL4^slbo.2.6

os^Scer\UAS.cZa

centripetally migrating follicle cell | ectopic | somatic clone, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

cuticle & adult external head, with Scer\GAL4^ey.PH

os^Scer\UAS.cCa

cyst cell | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

cyst progenitor cell, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

cyst progenitor cell | supernumerary, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

cyst progenitor cell | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

denticle belt & abdominal segment 4

os^UE69

denticle belt & abdominal segment 5

os^UE69

ectoderm | extended germ band stage

os^upd-4

egg chamber

os^hs.PM

embryonic/larval cuticle

embryonic/larval proventriculus

os^upd-3

embryonic abdominal segment 4

embryonic abdominal segment 5

embryonic abdominal segment 8

embryonic head, with Scer\GAL4^h-1J3

os^Scer\UAS.cZa

embryonic hindgut, with Df(1)os1A2, Scer\GAL4^byn-Gal4

os^Scer\UAS.cZa

embryonic hindgut, with Scer\GAL4^byn-Gal4

os^Scer\UAS.cZa

embryonic mesothoracic segment

os^UE69

embryonic metathoracic segment

embryonic segment

os^UE69

escort stem cell | supernumerary, with Scer\GAL4^C587

os^Scer\UAS.cZa

extended germ band embryo, with Scer\GAL4^da.G32

os^Scer\UAS.cZa

eye

eye, with Scer\GAL4^bi-omb-Gal4

os^Scer\UAS.cZa

eye, with Scer\GAL4^dpp.blk1

os^Scer\UAS.cZa

eye, with Scer\GAL4^elav.PLu

os^Scer\UAS.cZa

eye, with Scer\GAL4^ey.PH

eye, with Scer\GAL4^GMR.PF

eye, with Scer\GAL4^GMR.PU

os^Scer\UAS.cZa

eye (with Df(1)os1A2)

os^unspecified

eye (with os¹)

os^UE69

eye (with os^UE69)

os¹

eye | dorsal, with Scer\GAL4^30A

os^Scer\UAS.cZa

eye | somatic clone

eye | ventral, with Scer\GAL4^30A

os^Scer\UAS.cZa

eye-antennal disc

os^GMR.PB

eye disc

os^GMR.PB

eye disc, with Scer\GAL4^GMR.PF

os^Scer\UAS.cCa

eye disc | cell non-autonomous | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

os^Scer\UAS.cZa

eye disc | third instar larval stage

os¹

eye disc | third instar larval stage, with Scer\GAL4^dpp.blk1

os^Scer\UAS.cZa

eye disc | third instar larval stage, with Scer\GAL4^ey.PH

os^Scer\UAS.cZa

eye disc anterior to the morphogenetic furrow

os¹

eye disc anterior to the morphogenetic furrow, with Scer\GAL4^GMR.PF

os^Scer\UAS.cZa

female germline stem cell | supernumerary, with Scer\GAL4^C587

os^Scer\UAS.cZa

germarium, with Scer\GAL4^C587

os^Scer\UAS.cZa

germline cell | embryonic stage, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

germline cyst | supernumerary, with Scer\GAL4^C587

os^Scer\UAS.cZa

germline stem cell, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

germline stem cell | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cCa

gonad | ectopic & embryo

os^upd-4

interfollicle cell, with Scer\GAL4^neur-P72

os^Scer\UAS.cCa

interfollicle cell | supernumerary

os^hs.PM

intestinal stem cell | somatic clone, with Scer\GAL4^esg-NP5130

os^Scer\UAS.cZa

larval head

larval head | embryonic stage

os^UE69

male germline cell | supernumerary, with Scer\GAL4^A3.eya, Scer\GAL80^ts.αTub84B

os^Scer\UAS.cZa

male germline stem cell | supernumerary, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

male germline stem cell | supernumerary, with Scer\GAL4^nos.PG

os^Scer\UAS.cCa

male germline stem cell | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

mesothoracic segment

morphogenetic furrow, with Scer\GAL4^ey.PH

os^Scer\UAS.cCa

ommatidium

ommatidium, with Scer\GAL4^30A

os^Scer\UAS.cZa

ommatidium, with Scer\GAL4^GMR.PF

os^Scer\UAS.cCa

ommatidium (with os¹)

os^UE69

ommatidium (with os^UE69)

os¹

ommatidium | somatic clone

os^upd-4

ommatidium | somatic clone, with Scer\GAL4^Act5C.PI

os^Scer\UAS.cZa

ommatidium | supernumerary, with Scer\GAL4^GMR.PF

oocyte

os^hs.PM

oocyte associated follicle cell | somatic clone, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

ovariole, with Scer\GAL4^C587

os^Scer\UAS.cZa

photoreceptor cell R8 | supernumerary, with Scer\GAL4^GMR.PF

os^Scer\UAS.cZa

polar follicle cell

os^hs.PM

pole cell | ectopic, with Scer\GAL4^elav-C155

os^Scer\UAS.cZa

pole cell | ectopic, with Scer\GAL4^prd.RG1

os^Scer\UAS.cZa

pole cell | ectopic, with Scer\GAL4^twi.PG

os^Scer\UAS.cZa

primary gonial cell | supernumerary, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

primary gonial cell | supernumerary, with Scer\GAL4^nos.PG

os^Scer\UAS.cCa

primary gonial cell | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

round stem cell fusome | supernumerary, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

round stem cell fusome | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

somatic cell of testis | supernumerary, with Scer\GAL4^A3.eya, Scer\GAL80^ts.αTub84B

os^Scer\UAS.cZa

spermatogonium | supernumerary, with Scer\GAL4^Act5C.PP

os^Scer\UAS.cZa

spermatogonium | supernumerary, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

stem cell fusome, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

os^Scer\UAS.cZa

tergite

os^sisC-5

testis, with Scer\GAL4^A3.eya, Scer\GAL80^ts.αTub84B

os^Scer\UAS.cZa

testis, with Scer\GAL4^nos.PG

os^Scer\UAS.cCa

testis, with Scer\GAL4^{nos.UTR.T:Hsim\VP16}

wing

wing, with Scer\GAL4^Bx-MS1096

os^{Scer\UAS.T:Avic\GFP-EGFP}

wing disc, with Scer\GAL4^Bx-MS1096

os^Scer\UAS.cUa

Classical Alleles ( 19 )

For All Classical Alleles Show

Allele of os	Class	Mutagen	Stocks	Known lesion
os^s		spontaneous	16	--
os^o		X ray	8	--
os¹		X ray	3	--
os^upd-1		ethyl methanesulfonate	2	--
os^upd-4	loss of function allele	ethyl methanesulfonate	2	Yes
os^50a		spontaneous	0	--
os⁵⁴			0	--
os^bdw		X ray	0	--
os^d4-2			0	Yes
os^s:sisC-1		recombination	0	--
os^sisC-1	loss of function allele		0	Yes
os^sisC-2			0	Yes
os^sisC-3			0	Yes
os^sisC-4			0	Yes
os^sisC-5			0	Yes
os^UE69		gamma ray	0	--
os^unspecified			0	--
os^upd-2		ethyl methanesulfonate	0	--
os^upd-3		ethyl methanesulfonate	0	Yes

Alleles Carried on Transgenic Constructs ( 21 )

For All Alleles Carried on Transgenic Constructs Show

Allele of os	Mutagen	Stocks	Known lesion
os^GD1158	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
os^HMS00545	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
os^JF03149	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
os^Act5C.PB	in vitro construct - regulatory fusion	0	Yes
os^{Act5C.T:Avic\GFP-EGFP}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
os^{Act5C.T:SV5\V5}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
os^fl.cHa	in vitro construct	0	Yes
os^GMR.PB	in vitro construct - regulatory fusion	0	Yes
os^hs.PM	in vitro construct - regulatory fusion	0	Yes
os^{MtnA.T:SV5\V5}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
os^NIG.5993R	in vitro construct - regulatory fusion in vitro construct - RNAi	0	Yes
os^Scer\UAS.cCa	in vitro construct - regulatory fusion	0	Yes
os^Scer\UAS.cUa	in vitro construct - regulatory fusion	0	Yes
os^Scer\UAS.cZa	in vitro construct - regulatory fusion	0	Yes
os^{Scer\UAS.T:Avic\GFP-EGFP}	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
os^t10	in vitro construct - genomic fragment	0	Yes
os^t4.8	in vitro construct - genomic fragment	0	Yes
os^t5.8	in vitro construct - genomic fragment	0	Yes
os^T:Ivir\HA1	in vitro construct - coding region fusion	0	Yes
os^TM.Scer\UAS	in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
os^Δss	in vitro construct	0	Yes

Aneuploid Aberrations

Disrupted in

Df(1)BSC352

(Christensen and Cook, 2007.10.29)

Df(1)BSC716

(Christensen et al., 2008.12.28)

Df(1)N19

(Eberl et al., 1992, Harbecke and Lengyel, 1995)

Df(1)os1A2

(Agaisse et al., 2003, Eberl et al., 1992, Hombria et al., 2005)

Df(1)os^UE69

(Harrison et al., 1998, Eberl et al., 1992, Hombria et al., 2005)

In(1)sisC⁵

(Sefton et al., 1997)

Duplicated in

Dp(1;1)IMNB-8

Dp(1;1)MNB-8

Dp(1;1)NB-8

Dp(1;1)NBB-8

Dp(1;3)DC344

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;3)DC345

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;3)JC153

(Aguilera et al., 2000)

Dp(1;3)MNB-8

Dp(1;Y)BSC11

Dp(1;Y)BSC12

Dp(1;Y)BSC67

Dp(1;Y)BSC68

Dp(1;Y)BSC69

Dp(1;Y)BSC70

Dp(1;Y)BSC157

Not disrupted in

Df(1)274

(Patterson, 1932)

Df(1)N19

(Craymer and Roy, 1980)

In(1)Cl^Lbb^DfR

In(1)Cl^Ly^4R

In(1)y^4Lsc^4R

Tp(1;2)sn⁺72d

(Wieschaus et al., 1984)

Not duplicated in

Dp(1;3)126

Dp(1;f)100

(Morgan, 1938)

In(1)bb^DfLCl^R

Partially disrupted in

Df(1)os^4-51-1

Df(1)os¹⁰⁹

Df(1)os^c18

P{Mae-UAS.6.11}B1513^B1513

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

heat-shock construct

characterization construct

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

?{}os^sisC-1

insertion of mobile activating element

Gene Ontology: Function, Process & Cellular Component ( 31 unique terms )

Terms Based on Experimental Evidence ( 18 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

border follicle cell migration

References

apical constriction

inferred from mutant phenotype

(Bertet et al., 2009)

inferred from mutant phenotype

(Xi et al., 2003)

compound eye morphogenesis

inferred from mutant phenotype

(Tsai and Sun, 2004)

eye-antennal disc morphogenesis

inferred from mutant phenotype

(Ekas et al., 2006)

foregut morphogenesis

inferred from mutant phenotype

(Josten et al., 2004)

hindgut morphogenesis

inferred from mutant phenotype

(Johansen et al., 2003)

locomotor rhythm

inferred from mutant phenotype

(Luo and Sehgal, 2012)

long-term memory

inferred from mutant phenotype

(Copf et al., 2011)

mediolateral intercalation

inferred from mutant phenotype

(Bertet et al., 2009)

ovarian follicle cell development

inferred from mutant phenotype

(Xi et al., 2003, Medioni and Noselli, 2005)

paracrine signaling

inferred from direct assay

positive regulation of JAK-STAT cascade

inferred from direct assay

(Hombria et al., 2005, Wright et al., 2011)

inferred from genetic interaction with dome

inferred from genetic interaction with hop

inferred from genetic interaction with Ptp61F

inferred from genetic interaction with Socs36E

inferred from genetic interaction with Stat92E

inferred from mutant phenotype

primary sex determination

inferred from mutant phenotype

(Jinks et al., 2000)

regulation of embryonic cell shape

inferred from mutant phenotype

(Bertet et al., 2009)

stem cell division

inferred from mutant phenotype

(Kiger et al., 2001, Tulina and Matunis, 2001)

synaptic target recognition

inferred from mutant phenotype

(Kurusu et al., 2008)

Cellular Component

CV term

References

apical part of cell

inferred from direct assay

extracellular space

inferred from direct assay

Terms Based on Predictions or Assertions ( 16 terms )

Molecular Function

CV term

(Agaisse and Perrimon, 2004)

References

cytokine activity

traceable author statement

morphogen activity

non-traceable author statement

(Lopez-Schier, 2003)

receptor binding

non-traceable author statement

(Luo and Dearolf, 2001)

traceable author statement

(Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004)

Biological Process

CV term

border follicle cell migration

References

blastoderm segmentation

traceable author statement

(Luo and Dearolf, 2001)

traceable author statement

(Castelli-Gair Hombria and Brown, 2002)

defense response

non-traceable author statement

(Lemaitre, 2000.12.20)

embryonic development via the syncytial blastoderm

traceable author statement

(Agaisse and Perrimon, 2004)

germ-line stem cell division

traceable author statement

(Lin, 2002)

JAK-STAT cascade

non-traceable author statement

(Sefton, 2000.2.4, Lemaitre, 2000.12.20)

traceable author statement

(Jinks et al., 2000, Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004)

primary sex determination

non-traceable author statement

(Sefton, 2000.2.4)

sex determination

non-traceable author statement

(Luo and Dearolf, 2001)

sex determination, establishment of X:A ratio

non-traceable author statement

(Schutt and Nothiger, 2000)

somatic stem cell division

traceable author statement

(Lin, 2002)

stem cell division

traceable author statement

(Castelli-Gair Hombria and Brown, 2002)

Cellular Component

CV term

(Morey and Harrison, 1998, Sefton, 2000.2.4, Lemaitre, 2000.12.20)

References

extracellular region

non-traceable author statement

traceable author statement

(Jinks et al., 2000, Castelli-Gair Hombria and Brown, 2002, Agaisse and Perrimon, 2004, Lopez-Schier, 2003)

proteinaceous extracellular matrix

traceable author statement

(Jinks et al., 2000)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

os allele

Gene

References

os¹

(Brown et al., 2001, Ghiglione et al., 2002)

drm

(Johansen et al., 2003)

eyg

(Chao et al., 2004)

hop

(Kiger et al., 2001, Bach et al., 2003)

os^sisC-1

os^sisC-5

os^t4.8

os^t5.8

os^t10

(Badenhorst et al., 2002)

(McGregor et al., 2002)

os^upd-4

hop

(Harrison et al., 1998, McGregor et al., 2002)

unspecified

Brd

bun

cdc2

(Mukherjee et al., 2006, Chen et al., 2003)

Cdk4

CG4306

CG17574

CG32982

Cip4

clu

cpo

Csk

(Read et al., 2004)

CtBP

CycA

dap

jim

Lamp1

mir-14

Mob2

mthl8

NFAT

pAbp

poly

(Parkhurst and Ish-Horowicz, 1991)

Rac1

(Silver, 2005)

RpII140

rux

Sodh-2

spri

Ssdp

(Mukherjee et al., 2006, Silver and Montell, 2001, Read et al., 2004)

Stat92E

Tcp-1η

Ten-m

trbl

External Data

y¹ v¹; P{TRiP.JF03149}attP2

BioGRID - A database of protein and genetic interactions

•

59130

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0004956

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

32813

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

Q9VWW4

Orthologs

OrthoDB Orthologs (11) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG68SHD3

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (EOG68SHD3)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19283

Drosophila persimilis

Dper\GL27044

Drosophila willistoni

Dwil\GK19868

Drosophila mojavensis

Dmoj\GI15131

Drosophila grimshawi

Dgri\GH17790

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19283

Drosophila persimilis

Dper\GL27044

Drosophila willistoni

Dwil\GK19868

Drosophila virilis

Dvir\GJ18988

Drosophila mojavensis

Dmoj\GI15131

Drosophila grimshawi

Dgri\GH17790

Stocks & Reagents

Stocks Listed in FlyBase ( 34 )

Bloomington

os^o

os^s

667

os^s; tet¹

4767

w¹ os^upd-4/FM7a

4752

ff¹ Sh¹⁴ os^s/FM6

28722

Kyoto

105718

os^o

105719

os^s

107864

w¹ os^upd-4/FM7a

107859

ff¹ Sh¹⁴ os^s/FM6

107852

por¹⁵¹⁷⁵ os^s/FM6, w¹

VDRC

v3282

w¹¹¹⁸; P{GD1158}v3282

More stocks available...

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 4 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

AT13666

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

AT23111

Other clones

RNAi & Array Information

(Tulina and Matunis, 2001)

DRSC - Results from RNAi screens.

•

FBgn0004956

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

32813

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: os CG5993

(Li, 1999.11)

Source for database merge of

Source for merge of: os sisC

(Sefton et al., 1998)

Additional comments

"upd" and "os" can be genetically separated. This raises the possibility that "os" function may reside with an "upd-like" gene ("upd2" or "upd3").

(Wang, 2005)

Originally considered two separate loci, od: outstretched and sy: small eye, Muller proposed a single gene based on the recovery of a mutant with both phenotypes, which was not resolvable into two components by recombination as well as on the failure to recover recombinants between od and sy in transheterozygotes (Verderosa and Muller, 1954).

Other Comments

Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4^hs.PB.

(Liu and Lehmann, 2008)

dome

(Hombria et al., 2005)

os protein, secreted by the polar follicle cells, may act as a morphogen to specify anterior-posterior pattern in the ovarian follicle cells.

(Xi et al., 2003)

os is required for self-renewal of male germ line stem cells and somatic cyst progenitor cells.

Overexpression of os in the testis results in expansion of both the germ line stem cell and somatic cyst progenitor cell populations.

(Tulina and Matunis, 2001)

os acts as an X-linked signal element in sex determination.

os is necessary to determine the position of the eye equator via regulation of mirr.

(Zeidler et al., 1999)

A localised source of os protein, which is present at the midline of the developing eye, is capable of activating the JAK/STAT pathway over long distances.

(Zeidler et al., 1999)

os protein can activate the JAK signaling pathway.