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General Information
Symbol
Dmel\gig
Species
D. melanogaster
Name
gigas
Annotation Symbol
CG6975
Feature Type
FlyBase ID
FBgn0005198
Gene Model Status
Stock Availability
Gene Snapshot
gigas (gig) encodes a tumour suppressor protein that, together with with the product of Tsc1, controls cellular growth via antagonizing insulin and TOR signalling pathways. [Date last reviewed: 2019-03-07]
Also Known As
TSC2, dTsc2, l(3)109
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:20,129,181..20,139,010 [+]
Recombination map
3-46
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
RAP-LIKE GTPASE ACTIVATING PROTEINS -
Rap-like GTPase activating proteins (RapGAP) are an evolutionary-related group of RasGAPs that promote GTP hydrolysis by either Ral, Rap or Rheb subfamilies of the Ras GTPases. (Adapted from FBrf0229300).
TSC1-TSC2 COMPLEX -
The Tsc1-Tsc2 complex is a heterodimeric GTPase Activating Protein (GAP) complex that negatively regulates mTOR (TORC1 complex) signaling. The Tsc1-Tsc2 complex stimulates the small GTPase, Rheb, to hydrolyze bound GTP to GDP. GTP-bound Rheb activates TORC1. (Adapted from FBrf0214848 and FBrf0136941).
Pathway (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(3)109
Homozygous lethal; cell viable; homozygous cells 2-3 times normal size.
Summary (Interactive Fly)
Rap1 GAP domain protein - tuberous sclerosis-2 homolog - regulates growth rate - modifies the insulin pathway - maintains Drosophila germline stem cells by preventing differentiation
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\gig or the JBrowse view of Dmel\gig for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074819
5795
1847
FBtr0332690
5786
1844
Additional Transcript Data and Comments
Reported size (kB)
6.2 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074588
204.1
1847
8.05
FBpp0304936
203.8
1844
8.05
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gig using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (36 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from physical interaction with FLYBASE:Tor; FB:FBgn0021796
inferred from physical interaction with UniProtKB:Q9XYZ5
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q8T9I6
(assigned by UniProt )
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000006939
(assigned by GO_Central )
Biological Process (28 terms)
Terms Based on Experimental Evidence (25 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q8INB9
(assigned by UniProt )
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
inferred from mutant phenotype
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:Q8T9I6
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q9VCC9
(assigned by UniProt )
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Tsc1; FB:FBgn0026317
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:Q9VCC9
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Tor; FB:FBgn0021796
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000006943
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000006943
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000006942
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000006943
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000006943
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR000331
(assigned by InterPro )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Tsc1; FB:FBgn0026317
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000006939
(assigned by GO_Central )
inferred from electronic annotation with InterPro:IPR027107
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000006942
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:Tsc1; FB:FBgn0026317
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\gig in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 28 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 33 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of gig
Transgenic constructs containing regulatory region of gig
Deletions and Duplications ( 12 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior notopleural bristle & neuron | somatic clone
anterior scutellar bristle & neuron | somatic clone
eye disc & mitotic cell cycle | ectopic | somatic clone
eye disc & S phase | ectopic | somatic clone
humeral bristle & neuron | somatic clone
posterior notopleural bristle & neuron | somatic clone
vertical bristle & neuron | somatic clone
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
 
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
10 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (1)
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (3)
5 of 15
Yes
Yes
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (1)
6 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900EN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500CG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01EY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01D3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00O2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
2 of 10
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Comments on Models/Modifiers Based on Experimental Evidence ( 2 )
 
The amelioration of the phenotype in Npc1aKK101077 expressing flies is observed upon simultaneous co-expression of both Tsc1Scer\UAS.cTa and gigScer\UAS.cTa. sf161013
Co-expression (single expression of either construct untested) of Tsc1Scer\UAS.cGa and gigScer\UAS.cTa ameliorates neurodegenerative disease modeled by trpP365.
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Negative Regulators of Insulin-like Receptor Signaling Pathway -
Negative regulators of the Insulin-like Receptor signaling pathway suppress Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map
3-46
Cytogenetic map
Sequence location
3L:20,129,181..20,139,010 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
76F2-76F2
Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
77A1-77A2
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
This map location corrects that reported in FBrf0076453.
Stocks and Reagents
Stocks (19)
Genomic Clones (21)
cDNA Clones (76)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    polyclonal
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments
    gig and Rbf synergistically induce oxidative stress via increased protein synthesis, inhibited de novo lipid synthesis, and decreased reactive oxygen species enzyme induction.
    dsRNA made from templates generated with primers directed against this gene results in an increase in mean cell diameter.
    dsRNA made from templates generated with primers directed against CG32343, CG7845, CG10805, CG12301, CG5114, CG5033, CG10648, CG7006, CG3071, CG1542, bys, Ski6, RpI135, l(1)G0020, ppan, Nnp-1, NHP2, or pit in combination with dsRNA against gig results in suppression of the final average cell size, with it being closer to the control average cell size, rather than the average cell size resulting from knockdown of the candidate gene alone.
    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
    dsRNA made from templates generated with primers directed against this gene decreases the level of Akt1 phosphorylation, especially in response to insulin stimulation, in S2 cells.
    One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Loss of Tsc1 and gig results in a Tor-dependent increase in S6k activity. gig mutant cells fail to respond to amino acid starvation by decreasing S6k activity.
    Tsc1 acts, as part of a complex with gig, to antagonise Tor.
    Area matching Drosophila EST AI456286. Probable intron in gene represented by EST AI456286.
    gig is a negative regulator of insulin signalling.
    In contrast to the findings reported in FBrf0107789, it has become apparent that while gig mutant cells are enlarged, there is no endoreduplication of their DNA.
    Mutations in gig result in enhanced growth and cell size with no change in ploidy. Overall, mutant cells spend less time in G1.
    gig blocks rereplication of DNA or promotes mitosis during imaginal disc development.
    gig mutant cells accumulate G2 cyclins. gig is required for oogenesis making it impossible to generate eggs that completely lack gig product.
    Study of synaptic frequency in the enlarged neurons of mutants reveals a causal relationship between cell size and synaptic number: the frequency of synaptic profiles increases as the size of terminal perimeters is increased.
    Origin and Etymology
    Discoverer
    Etymology
    'gigas' means 'giant' in Latin.
    Identification
    External Crossreferences and Linkouts ( 61 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (19)
    Reported As
    Symbol Synonym
    TSC2
    (Galenza and Foley, 2019, Lee et al., 2019, Cara et al., 2018, Inoue et al., 2018, Lee et al., 2018, Staats et al., 2018, Tang et al., 2018, Haller et al., 2017, Liu and Jin, 2017, Romero-Pozuelo et al., 2017, Stefana et al., 2017, Sun et al., 2017, Wen et al., 2017, Yun et al., 2017, Agrawal et al., 2016, Danielsen et al., 2016, Grill et al., 2016, Koyama and Mirth, 2016, Tsokanos et al., 2016, Aradhya et al., 2015, Fischer et al., 2015, Housden et al., 2015, Kim and Lee, 2015, Nässel et al., 2015, Nie et al., 2015, Sano et al., 2015, Zhang and Baehrecke, 2015, Varma et al., 2014, Quan et al., 2013, Shim et al., 2013, Tang et al., 2013, Wong et al., 2013, Yamanaka et al., 2013, Denton et al., 2012, Kapuria et al., 2012, Pallares-Cartes et al., 2012, Papatheodorou et al., 2012, Pircs et al., 2012, Tokusumi et al., 2012, Zitserman et al., 2012, Lindquist et al., 2011, Oldham, 2011, Resnik-Docampo and de Celis, 2011, Serfontein et al., 2011, Storelli et al., 2011, Yang and Xu, 2011, Birse et al., 2010, Bland et al., 2010, Chang and Neufeld, 2010, Cully et al., 2010, Kalender et al., 2010, Lam et al., 2010, Lee et al., 2010, Li et al., 2010, Géminard et al., 2009, Slaidina et al., 2009, Layalle et al., 2008, Porstmann et al., 2008, Bourouis et al., 2007, Gutierrez et al., 2007, Hoshizaki and Gibbs, 2007, Hsu and Choi, 2007, Knox et al., 2007, Lasko and Sonenberg, 2007, Tyler et al., 2007, Edgar, 2006, Edgar, 2006, Guertin et al., 2006, Lee et al., 2006, Min et al., 2006, Wu and Brown, 2006, Wullschleger, 2006, Yang et al., 2006, Hay and Sonenberg, 2004, Leopold, 2004, Scott et al., 2004, Scott et al., 2004, Stocker et al., 2004, Colombani et al., 2003, Lee and Orr-Weaver, 2003, Neufeld, 2003, Nijhout, 2003, Stocker et al., 2003, Potter et al., 2002, Gao and Pan, 2001, Ito and Rubin, 2001, Tapon and Hariharan, 2001)
    Tsc2
    (Jia et al., 2018, Kang et al., 2018, Lehmann, 2018, Nowak et al., 2018, Mensah et al., 2017, Murillo-Maldonado and Riesgo-Escovar, 2017, Allen et al., 2016, Kuleesha et al., 2016, Le et al., 2016, Yadav et al., 2016, Androschuk et al., 2015, Das and Dobens, 2015, Serbus et al., 2015, Deivasigamani et al., 2014, Ghosh et al., 2014, Hayashi et al., 2014, Sun et al., 2014, Wang et al., 2014, Ibar et al., 2013, Mukherjee and Duttaroy, 2013, Natarajan et al., 2013, Nowak et al., 2013, Tran et al., 2013, Chakrabarti et al., 2012, Kapuria et al., 2012, Marinari et al., 2012, Papatheodorou et al., 2012, Friedman et al., 2011, Sousa-Nunes et al., 2011, Karbowniczek et al., 2010, Montagne et al., 2010, Ribeiro and Dickson, 2010, Sun et al., 2010, Zheng and Sehgal, 2010, Chang and Neufeld, 2009, Demontis and Perrimon, 2009, Nuzhdin et al., 2009, Schleich and Teleman, 2009, Sims et al., 2009, Wang et al., 2009, Hou et al., 2008, Hu et al., 2008, Juhász et al., 2008, Lee et al., 2008, Vereshchagina et al., 2008, Scott et al., 2007, Steinhilb et al., 2007, Khurana et al., 2006, Patel and Tamanoi, 2006, Zhang et al., 2006, Goberdhan et al., 2005, Hennig et al., 2005, Patel and Tamanoi, 2005, Teleman et al., 2005, Ackley and Jin, 2004, Aspuria and Tamanoi, 2004, Bilder, 2004, Coffman, 2004, Dong and Pan, 2004, Jorgensen and Tyers, 2004, Kapahi et al., 2004, Murthy et al., 2004, Pan et al., 2004, Reiling and Hafen, 2004, Ryoo and Steller, 2003, Saucedo et al., 2003, Saucedo et al., 2003, Stocker et al., 2003, Wu et al., 2003, Zhang et al., 2003, Gao et al., 2002, Pfleger et al., 2002, Potter et al., 2002, Lawlor and Alessi, 2001, Potter et al., 2001, Tapon et al., 2001, Tapon et al., 2001)
    Secondary FlyBase IDs
      Datasets (1)
      Study focus (1)
      Experimental Role
      Project
      Project Type
      Title
      • bait_protein
      Interaction map generated by purification of insulin pathway factors, with identification of copurifying proteins by mass spectrometry.
      References (305)