FB2025_01 , released February 20, 2025
Gene: Dmel\Su(fu)
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General Information
Symbol
Dmel\Su(fu)
Species
D. melanogaster
Name
Suppressor of fused
Annotation Symbol
CG6054
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005355
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Summary
Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Sufu

Key Links
Genomic Location
Cytogenetic map
87C5-87C5
Sequence location
Recombination map
3-52
RefSeq locus
NT_033777 REGION:12689873..12691468
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor binding
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Han et al., 2015, Monnier et al., 1998)
enables molecular sequestering activity
inferred from mutant phenotype
(Shi et al., 2014, Wang et al., 2000)
inferred from direct assay
(Han et al., 2019, Han et al., 2015, Oh et al., 2015)
enables nuclear localization sequence binding
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Shi et al., 2014)
enables RNA polymerase II-specific DNA-binding transcription factor binding
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Zhang et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in negative regulation of nucleocytoplasmic transport
inferred from direct assay
(Methot and Basler, 2000)
involved_in negative regulation of smoothened signaling pathway
inferred from genetic interaction with FLYBASE:ci; FB:FBgn0004859
(Han et al., 2019, Han et al., 2015, Smelkinson et al., 2007)
inferred from genetic interaction with FLYBASE:smo; FB:FBgn0003444,FLYBASE:CkIα; FB:FBgn0015024
(Zhou and Kalderon, 2011)
inferred from direct assay
(Zhang et al., 2011, Fukumoto et al., 2001, Methot and Basler, 2000)
inferred from mutant phenotype
(He et al., 2022, Oh et al., 2015, Spratford and Kumar, 2013, Ohlmeyer and Kalderon, 1998)
inferred from genetic interaction with FLYBASE:sgg; FB:FBgn0003371
(Jia et al., 2002)
inferred from genetic interaction with FLYBASE:rdx; FB:FBgn0264493
(Seong and Ishii, 2013)
inferred from genetic interaction with FLYBASE:cos; FB:FBgn0000352
(Shi et al., 2014, Wang et al., 2000)
inferred from genetic interaction with FLYBASE:slmb; FB:FBgn0283468
(Wang et al., 1999)
inferred from genetic interaction with FLYBASE:fu; FB:FBgn0001079
(Shi et al., 2011)
inferred from genetic interaction with FLYBASE:Tnpo; FB:FBgn0024921
(Shi et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of smoothened signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000859153
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Stegman et al., 2004)
located_in cytosol
inferred from direct assay
(Sisson et al., 2006, Stegman et al., 2004, Stegman et al., 2000)
located_in nucleus
inferred from direct assay
(Sisson et al., 2006)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:fu; FB:FBgn0001079
(Monnier et al., 1998)
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Monnier et al., 1998)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000859153
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000859153
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity. [Date last reviewed: 2019-09-26]
Pathway (FlyBase)
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Su(fu): Suppressor of fused
Dominant suppressor of both the wing phenotype and the maternally determined lethality of fu mutants.
Summary (Interactive Fly)

novel protein with PEST sequence - inhibits Hedgehog signaling pathway - forms a complex with the transcription factor Cubitus interruptus to inhibit its activity.

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Su(fu) for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VG38)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Su(fu)-RA
FBtr0082665
NM_080502
1596
468
Additional Transcript Data and Comments
Reported size (kB)

1.6 (northern blot)

(Pham et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Su(fu)-PA
FBpp0082134
52.8
468
4.63
Q9VG38
NP_536750
AAF54852
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

468 (aa); 53 (kD predicted)

(Pham et al., 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(fu) using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.22

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Pham et al., 1995)
adult stage | female
(Pham et al., 1995)
Additional Descriptive Data

Su(fu) transcripts are predominantly expressed in adult females and early embryos. Transcripts are expressed uniformly throughout the embryo from preblastoderm to shortened germ band stages.

(Pham et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Stegman et al., 2004)
located_in cytosol
inferred from direct assay
(Sisson et al., 2006, Stegman et al., 2004, Stegman et al., 2000)
located_in nucleus
inferred from direct assay
(Sisson et al., 2006)
part_of protein-containing complex
inferred from physical interaction with FLYBASE:fu; FB:FBgn0001079
(Monnier et al., 1998)
inferred from physical interaction with FLYBASE:ci; FB:FBgn0004859
(Monnier et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Su(fu) in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(fu)
Transgenic constructs containing regulatory region of Su(fu)
Aberrations (Deficiencies and Duplications) ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\SUFU
14 of 14
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Sufu
14 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Sufu
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\sufu
8 of 13
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\sufu
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP001948
12 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Su(fu). Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
SUFU; SUFU negative regulator of hedgehog signaling
14 of 14
607035
 
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Show/hide secondary interactors 
(data from AllianceMine provided by esyN)
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Other Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Su(fu) - Sxl
anti bait coimmunoprecipitation, western blot
(Horabin et al., 2003)
Su(fu) - ci
anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, autoradiography, anti bait coimmunoprecipitation, western blot, molecular sieving, isothermal titration calorimetry, predetermined participant, fluorescent resonance energy transfer, fluorescence microscopy
(Zhou et al., 2022, Han et al., 2019, Han et al., 2015, Oh et al., 2015, Zhou et al., 2015, Shi et al., 2014, Zhang et al., 2013, Shi et al., 2011, Farzan et al., 2009, Zhang et al., 2006, Paces-Fessy et al., 2004, Wang and Jiang, 2004, Lum et al., 2003, Methot and Basler, 2000, Stegman et al., 2000, Monnier et al., 1998, Paumard-Rigal et al., 1998)
Su(fu) - cos
anti bait coimmunoprecipitation, western blot, pull down, molecular sieving
(Farzan et al., 2009, Lum et al., 2003, Stegman et al., 2000)
Su(fu) - fu
x-ray crystallography, anti bait coimmunoprecipitation, western blot, isothermal titration calorimetry, predetermined participant, molecular sieving, pull down, molecular weight estimation by staining, two hybrid, affinity chromatography technology, autoradiography, protein kinase assay, anti tag western blot, anti tag coimmunoprecipitation
(Li et al., 2020, Oh et al., 2015, Zhang et al., 2011, Farzan et al., 2009, Paces-Fessy et al., 2004, Lum et al., 2003, Stegman et al., 2000, Monnier et al., 1998)
Summary of Genetic Interactions
esyN Network Diagram
Show/hide secondary interactors 
(data from AllianceMine provided by esyN)
esyN Network Key:
Suppression
Enhancement
Other Interaction Browsers
View in FlyBase Interactions Browser   View in MIST tool (external link)
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Su(fu)
enhanceable
fu
(Dussillol-Godar et al., 2006)
Su(fu)
enhanceable
ptc
(Ayers et al., 2009)
Su(fu)|fu
suppressible
sauf
(Marcilliere and Limbourg-Bouchon, 1997)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
fu
enhanceable
Su(fu)
(Preat et al., 1993)
fu
suppressible
Su(fu)
(Besse et al., 2002, Delattre et al., 1999, Preat et al., 1993, Preat, 1992)
Gmap
enhanceable
Su(fu)
(Friggi-Grelin et al., 2008)
Mlf
enhanceable
Su(fu)
(Fouix et al., 2003)
Pka-C1
enhanceable
Su(fu)
(Zhang and Kalderon, 2000, Ohlmeyer and Kalderon, 1998)
ptc
enhanceable
Su(fu)
(Ohlmeyer and Kalderon, 1998)
ptc
suppressible
Su(fu)
(Mullor and Guerrero, 2000)
sgg
enhanceable
Su(fu)
(Jia et al., 2002)
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
FlyBase
External Links
External Data
Linkouts
KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Class of Gene
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3R
Recombination map
3-52
Cytogenetic map
87C5-87C5
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
87C5-87C5
Limits computationally determined from genome sequence between P{lacW}Vha55j2E9 and P{PZ}CtBP03463
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
87C8-87C8
(Tricoire, 1996.2.9, Tricoire, 1996.2.13)
87C-87C
(determined by in situ hybridisation)
(Tricoire, 1992)
Experimentally Determined Recombination Data
Location

3-52

(FlyBase, 2016)

3-50.0

(Comeron et al., 2012)

3-50.7-53.1

Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (12)
Genomic Clones (8)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (44)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
Antibody Information
Laboratory Generated Antibodies
 

polyclonal

(Monnier et al., 1998)
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Cell Line Information
Publicly Available Cell Lines
 
    Other Stable Cell Lines
     
      Other Comments

      Su(fu) enters the nucleus in response to hh signaling.

      (Sisson et al., 2006)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)

      Using the yeast two-hybrid method and an in vitro binding assay it is demonstrated that Su(fu), ci and fu can interact directly to form a trimolecular complex, with Su(fu) binding to both its partners simultaneously. In the absence of hh signalling results propose that Su(fu) inhibits ci by binding to it and that, upon reception of the hh signal, fu is activated and counteracts Su(fu), leading to the activation of ci.

      (Monnier et al., 1998)

      Su(fu) and fu modify wing phenotypes due to hh signalling.

      (Ohlmeyer and Kalderon, 1998)

      The small lobe of fu may play a role in generating the neomorphic cos phenotype displayed by an unregulated fu protein in a Su(fu)- background.

      (Alves et al., 1995)

      Genetic and molecular data suggests that fu and Su(fu) could act through a competitive posttransductional modification of a common target in the hh signalling pathway.

      (Pham et al., 1995)

      Alleles of Su(fu) complement alleles of l(3)87Ca, l(3)87Cb, l(3)87Cc and l(3)87Cd, and kar.

      (Preat, 1992)

      Mutant Su(fu) embryos can be rescued by P-element mediated transformation of a 4.7kb wild type Su(fu) gene fragment.

      (Tricoire et al., 1992)

      Su(fu) suppresses the segment polarity and zygotic phenotype of one class of fu alleles and causes a lethal interaction with the other class of fu alleles.

      (Preat et al., 1989)
      Relationship to Other Genes
      Source for database merge of
      Additional comments

      FlyBase curator comment: the insertion in the "c04425" Exelixis line (PBac{PB}Arp87Cc04425) was originally assigned to the Su(fu) gene in FBrf0179797, resulting in the "Su(fu)c04425" (FBal0159716) allele. However, FBrf0184340 shows that the insertion is actually within Arp87C.

      (Bloomington Drosophila Stock Center, 2004.11.6)
      Nomenclature History
      Source for database identify of
      Nomenclature comments
      Etymology
      Synonyms and Secondary IDs (14)
      Reported As
      Symbol Synonym
      CG6054
      (Anholt and Williams, 2010, Ni et al., 2010.12.1, Perkins et al., 2009)
      SU(FU)
      (Plessis et al., 2007, Martin-Lanneree et al., 2006)
      SUFU
      (Mirzoyan et al., 2019, Ingham et al., 2011, Claret et al., 2007, Sanial and Plessis, 2007)
      Su(Fu)
      (Walthall et al., 2007, Wicking et al., 1999)
      Su(fu)
      (He et al., 2022, Little et al., 2020, Tokusumi et al., 2018, Garcia-Garcia et al., 2017, Transgenic RNAi Project members, 2017-, Lee et al., 2016, Moulton and Letsou, 2016, Sarov et al., 2016, Oh et al., 2015, Kim et al., 2014, Liu et al., 2014, Hooper, 2013.5.30, Spratford and Kumar, 2013, Japanese National Institute of Genetics, 2012.5.21, Marks and Kalderon, 2011, Toku et al., 2011, Zhang et al., 2011, Zhou and Kalderon, 2011, Pospisilik et al., 2010, Zhou and Kalderon, 2010, Friggi-Grelin et al., 2008, Smelkinson et al., 2007, Walthall et al., 2007, Dussillol-Godar et al., 2006, Sisson et al., 2006, Varjosalo et al., 2006, Zhou et al., 2006, Briscoe and Therond, 2005, Dawber et al., 2005, Ishii, 2005, Nybakken et al., 2005, Torroja et al., 2005, Wang and Jiang, 2004, Fouix et al., 2003, Monnier et al., 2002, Methot and Basler, 2000, Wang et al., 2000, Monnier et al., 1998)
      SuFu
      (Makamte et al., 2022, Zhou et al., 2022, Zhao et al., 2021, Briscoe and Thérond, 2013, Mbodj et al., 2013, Cheng et al., 2012, Ayers et al., 2009, Zhao et al., 2007, Sherr, 2004, Johnson and Scott, 1997)
      Sufu
      (Jang et al., 2024, Surkova et al., 2021, Zhang and Jiang, 2021, Li et al., 2020, Han et al., 2019, Zhou et al., 2018, Zhao et al., 2017, Ma et al., 2016, Han et al., 2015, Zhou et al., 2015, Shi et al., 2014, Shi et al., 2014, Chen and Jiang, 2013, Robbins et al., 2012, Shi et al., 2011, Raisin et al., 2010, Ayers et al., 2009, Farzan et al., 2009, Osterlund and Kogerman, 2006, Zhang et al., 2006, Besse et al., 2002, Monnier et al., 1999, Ruiz i Altaba, 1999, Delattre et al., 1997)
      d Sufu
      (Paces-Fessy et al., 2004)
      dSufu
      (Zhang et al., 2013)
      su(fu)
      (Kalderon, 2002, Theil et al., 1999, Tabin and McMahon, 1997)
      sufu
      (Zhang et al., 2020, Cheng et al., 2012)
      Name Synonyms
      Suppressor of Fused
      (Zhao et al., 2017, Cheng et al., 2012, Ayers et al., 2009, Sanial and Plessis, 2007, Walthall et al., 2007, Croker et al., 2006, Torroja et al., 2005, Monnier et al., 2002)
      Suppressor of fused
      (Shi et al., 2014, Spratford and Kumar, 2013, Farzan et al., 2009, Plessis et al., 2007, Zhao et al., 2007, Martin-Lanneree et al., 2006, Sisson et al., 2006, Dawber et al., 2005)
      suppressor of fused
      (Friggi-Grelin et al., 2008, Tricoire, 1996.2.9, Tricoire, 1996.2.13)
      Secondary FlyBase IDs
      • FBgn0003562
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 55 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
      FlyMine - An integrated database for Drosophila genomics
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      MARRVEL_MODEL - MARRVEL (model organism gene)
      PDB - An information portal to biological macromolecular structures
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
      References (218)