• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Su(fu)

General Information
Symbol	Dmel\Su(fu)	Species	D. melanogaster
Name	Suppressor of fused	Annotation symbol	CG6054
Feature type	protein_coding_gene	FlyBase ID	FBgn0005355
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	SuFu
Genomic Location
Chromosome (arm)	3R	Recombination map	3-50.7--53.1
Cytogenetic map	87C5-87C5	Sequence location	3R:8,515,595..8,517,434 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Suppressor of fused is referred to in FlyBase by the symbol Dmel\Su(fu) (CG6054, FBgn0005355). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding. There is experimental evidence that it is involved in the biological process: negative regulation of sequence-specific DNA binding transcription factor activity; cytoplasmic sequestering of transcription factor; negative regulation of smoothened signaling pathway. 21 alleles are reported. The phenotypes of these alleles are annotated with: sensillum campaniformium of dorsal radius; wing margin; wing disc; antenna; axillary vein; prothoracic leg; metathoracic leg; egg chamber; wing vein; costal vein. It has one annotated transcript and one annotated polypeptide. Protein features are: Suppressor of fused C-terminal; Suppressor of fused domain; Suppressor of fused protein; Suppressor of fused-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1638427_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Su(fu). Gene sequence location is 3R:8515595..8517434.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Su(fu): Suppressor of fused Dominant suppressor of both the wing phenotype and the maternally determined lethality of fu mutants.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 87C5-87C5   Limits computationally determined from genome sequence between P{lacW}Vha55j2E9 and P{PZ}CtBP03463
Experimentally Determined Cytological Location
Cytogenetic map Notes References 87C8-87C8     (Tricoire, 1996.2.9) 87C8-87C8     (Tricoire, 1996.2.13) 87C-87C   (determined by in situ hybridisation)   (Tricoire, 1992)
Experimentally Determined Recombination Data
Location	3-50.7--53.1
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Su(fu) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Su(fu)-RA FBtr0082665  NM_080502   1840   468
Additional Transcript Data & Comments
Reported size (kB)	1.6 (northern blot) (Pham et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Su(fu)-PA   FBpp0082134   52.8   468   4.63     NP_536750   AAF54852
Additional Polypeptide Data & Comments
Reported size (kDa)	468 (aa); 53 (kD predicted) (Pham et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Suppressor of fused-like (IPR007768) Suppressor of fused protein (IPR016591) Suppressor of fused C-terminal (IPR024314) Suppressor of fused domain (IPR020941)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202262   AA246890   AA246912   AA390785   AA391763   AA440952   AA539397   AA539903   AA803737   AA817620   AA950030   AA950146   AE014297 AAF54852   AI064586   AI113953   AI402212   AI405269   AI512408   AI512957   AI514479   AI515376   AI515543   AW941381   AY069285 AAL39430   BI173877   BI365317   BI368564   BI369360   BI375613   BI483778   BI484172   BI576620   BI579889   BI582780   BI588698   BQ103680   CO292883   CO318237   CO323237   D83486 BAA11929   EC066776   EC223645   EC235613   EC236120   EC240870   EC248313   EL882254   EL882347   EL882584   U48859 AAA93016   X95652 CAA64954
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VG38 Q27279
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Pham et al., 1995) adult stage | female     (Pham et al., 1995)
Additional Descriptive Data
	Su(fu) transcripts are predominantly expressed in adult females and early embryos. Transcripts are expressed uniformly throughout the embryo from preblastoderm to shortened germ band stages. (Pham et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Stegman et al., 2004) colocalizes_with Hedgehog signaling complex inferred from physical interaction with ci AND inferred from physical interaction with fu (Stegman et al., 2000) protein complex inferred from physical interaction with ci (Monnier et al., 1998) inferred from physical interaction with fu (Monnier et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    87.1 Larval Midgut    35 Larval Hindgut    90.4 Larval Malpighian Tubules    89 Larval Fat Body    78.4 Larval Salivary Gland    104.8 Larval Trachea    162.85 Larval Carcass    100.925 Adult Head    63.5 Adult Eye    76.975 Adult Brain    68.5 Adult Thoracic-Abdominal Ganglion    69 Adult Crop    133.9 Adult Midgut    49 Adult Hindgut    123.7 Adult Malpighian Tubules    83.9 Adult Fat Body    70.7 Adult Salivary Gland    101.2 Adult Heart    65.75 Adult VirginFemale Spermatheca    54.3 Adult InseminatedFemale Spermatheca    62.4 Adult Ovary    200.5 Adult Testis    48.9 Adult Male Accessory Gland    107.1 Adult Carcass    69.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    63.5   NA  Eye    76.975   NA  Brain    68.5   87.1  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    69   NA  Crop    133.9   35  Midgut    49   90.4  Hindgut    123.7   89  Malpighian Tubules    83.9   78.4  Fat Body    70.7   104.8  Salivary Gland    101.2   NA  Heart    65.75   162.85  Trachea    NA   NA  VirginFemale Spermatheca    54.3   NA  InseminatedFemale Spermatheca    62.4   NA  Ovary    200.5   NA  Testis    48.9   NA  Male Accessory Gland    107.1   100.925  Carcass    69.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female  (32) ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female  32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    24 central nervous system, larvae L3    13 central nervous system, pupae P8    9 head, virgin 1-day female    5 head, virgin 4-day female    4 head, virgin 20-day female    6 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    5 head, mated 20-day male    8 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    12 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    2 fat body, white prepupae    8 fat body, pupae P8    11 carcass, larvae L3 wandering    17 carcass, 1-day adult    4 carcass, 4-day adult    5 carcass, 20-day adult    7 ovary, virgin 4-day female    32 ovary, mated 4-day female    25 testis, mated 4-day male    21 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    77 embryo 04-06hr    77 embryo 06-08hr    54 embryo 08-10hr    46 embryo 10-12hr    40 embryo 12-14hr    25 embryo 14-16hr    28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (55) embryo 02-04hr  (77) embryo 04-06hr  (77) embryo 06-08hr  (54) embryo 08-10hr  (46) embryo 10-12hr  (40) embryo 12-14hr    25 embryo 14-16hr  (28) embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day  (27) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    77 embryo 04-06hr    77 embryo 06-08hr    54 embryo 08-10hr    46 embryo 10-12hr    40 embryo 12-14hr    25 embryo 14-16hr    28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    77 embryo 04-06hr    77 embryo 06-08hr    54 embryo 08-10hr    46 embryo 10-12hr    40 embryo 12-14hr    25 embryo 14-16hr    28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day    27 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    77 embryo 04-06hr    77 embryo 06-08hr    54 embryo 08-10hr    46 embryo 10-12hr    40 embryo 12-14hr    25 embryo 14-16hr    28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (55) embryo 02-04hr  (77) embryo 04-06hr  (77) embryo 06-08hr  (54) embryo 08-10hr  (46) embryo 10-12hr  (40) embryo 12-14hr    25 embryo 14-16hr  28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day  27 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    77 embryo 04-06hr    77 embryo 06-08hr    54 embryo 08-10hr    46 embryo 10-12hr    40 embryo 12-14hr    25 embryo 14-16hr    28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    55 embryo 02-04hr    77 embryo 04-06hr    77 embryo 06-08hr    54 embryo 08-10hr    46 embryo 10-12hr    40 embryo 12-14hr    25 embryo 14-16hr    28 embryo 16-18hr    20 embryo 18-20hr    13 embryo 20-22hr    18 embryo 22-24hr    18 larva L1    11 larva L2    10 larva L3 12hr old    9 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    19 white prepupae new    20 white prepupae 12hr    20 white prepupae 24hr    25 pupae 2d postWPP    18 pupae 3d postWPP    10 pupae 4d postWPP    9 adult male 01day    10 adult male 05day    11 adult male 30day    11 adult female 01day    20 adult female 05day    27 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    9 embryonic S1    26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (32) Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2  (27) embryonic Kc167    9 embryonic S1  26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (27) mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    9 embryonic S1    26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    9 embryonic S1    26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    9 embryonic S1    26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2  27 embryonic Kc167    9 embryonic S1  26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (37) eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    9 embryonic S1    26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    24 embryonic 1182-4H    21 embryonic GM2    27 embryonic Kc167    9 embryonic S1    26 embryonic S3    20 leg disc CME L1    20 wing disc CME-W2    15 wing disc ML-DmD8    21 wing disc ML-DmD9    17 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    22 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    37 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    27 mixed discs ML-DmD4-c1    23 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    16 tumorous blood cells mbn2    9 ovary fGS/OSS    18 ovary OSC    17 ovary OSS    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3  26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    4 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    10 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    5 Ethanol 2.5% 3 hrs, larvae L3    26 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GM14141 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005355 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6054-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa viable Su(fu)1 Su(fu)E Su(fu)LP viable, with Scer\GAL4pnr-MD237 Su(fu)GD11802 viable, with Scer\GAL4vg.int2.1 Su(fu)Scer\UAS.cDa Other Phenotypes Allele wild-type Su(fu)+t4.5 Su(fu)+t11.3 Phenotype manifest in Allele antenna, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa axillary vein, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa axillary vein, with Scer\GAL4vg.int2.1 Su(fu)Scer\UAS.cDa costal vein, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa costal vein, with Scer\GAL4vg.int2.1 Su(fu)Scer\UAS.cDa egg chamber Su(fu)LP metathoracic leg, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa prothoracic leg, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa sensillum campaniformium of dorsal radius Su(fu)LP sex comb | supernumerary, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa wing disc, with Scer\GAL4Act5C.PP Su(fu)Scer\UAS.cDa wing margin, with Scer\GAL4da.G32 Su(fu)Scer\UAS.cDa wing margin, with Scer\GAL4vg.int2.1 Su(fu)Scer\UAS.cDa wing vein Su(fu)LP
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Su(fu) Class Mutagen Stocks Known lesion Su(fu)HP31389 transposable element activity 1 -- Su(fu)HP37259 1 -- Su(fu)LP amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Su(fu)12d hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- Su(fu)1 ethyl methanesulfonate 0 -- Su(fu)E X ray 0 -- Su(fu)unspecified 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Su(fu) Class Mutagen Stocks Known lesion Su(fu)GD11802 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(fu)HM05045 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(fu)+t11.3 in vitro construct - genomic fragment 0 Yes Su(fu)+t4.5 in vitro construct - genomic fragment 0 Yes Su(fu)000 in vitro construct - genomic fragment 0 Yes Su(fu)Act5C.PC in vitro construct - regulatory fusion 0 Yes Su(fu)Act5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(fu)Act5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(fu)Act5C.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes Su(fu)dsRNA.cLa in vitro construct - RNAi 0 Yes Su(fu)NIG.6054R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Su(fu)Scer\UAS.cCa in vitro construct - regulatory fusion 0 Yes Su(fu)Scer\UAS.cDa in vitro construct - regulatory fusion 0 Yes Su(fu)Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6166 (Ryder, 2004.4.26) Df(3R)kar3Q (Preat, 1992) Df(3R)kar-Sz11 (Monnier et al., 1998, Preat, 1992, Pham et al., 1995) Df(3R)kar-Sz21 (Monnier et al., 1998, Preat, 1992, Pham et al., 1995) Df(3R)Su(fu)LP (Mullor and Guerrero, 2000) Df(3R)Su(fu)A (Pham et al., 1995)
Duplicated in	Dp(3;2)ry+ (Preat, 1992)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11802} NA P{NIG.6054R} NA P{TRiP.HM05045} NA P{UAS-mycSu(fu)} NA P{UAS-Su(fu).C} NA P{UAS-Su(fu).D} NA characterization construct P{SUFU000} NA P{SUFU100} NA P{SUFU200} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPg}Su(fu)HP31389 NA P{EPg}Su(fu)HP37259 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
transcription factor binding inferred from physical interaction with ci (Monnier et al., 1998)
Biological Process
CV term Evidence References
cytoplasmic sequestering of transcription factor inferred from mutant phenotype (Wang et al., 2000) negative regulation of sequence-specific DNA binding transcription factor activity inferred from genetic interaction with cos (Wang et al., 2000) negative regulation of smoothened signaling pathway inferred from genetic interaction with cos (Wang et al., 2000)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Stegman et al., 2004) colocalizes_with Hedgehog signaling complex inferred from physical interaction with ci AND inferred from physical interaction with fu (Stegman et al., 2000) protein complex inferred from physical interaction with ci (Monnier et al., 1998) inferred from physical interaction with fu (Monnier et al., 1998)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of smoothened signaling pathway non-traceable author statement (Jiang, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Su(fu) - Aats-lys anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(fu) - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(fu) - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(fu) - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(fu) - ci fluorescent resonance energy transfer, anti tag coimmunoprecipitation, anti tag western blot (Shi et al., 2011) Su(fu) - fu protein kinase assay, anti tag western blot (Zhang et al., 2011) Su(fu) - proPO45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(fu) - proPO59 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Su(fu) - robl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Su(fu) allele Gene References Su(fu)12d fu (Preat, 1992) Su(fu)LP fu (Preat, 1992, Preat et al., 1993, Marcilliere and Limbourg-Bouchon, 1997, Delattre et al., 1999, Besse et al., 2002) Pka-C1 (Ohlmeyer and Kalderon, 1998, Zhang and Kalderon, 2000) ptc (Ohlmeyer and Kalderon, 1998, Mullor and Guerrero, 2000) sgg (Jia et al., 2002) unspecified cos (Preat et al., 1993) fu (Dussillol-Godar et al., 2006) hh (Ohlmeyer and Kalderon, 1998) Mlf (Fouix et al., 2003) sauf (Marcilliere and Limbourg-Bouchon, 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66658 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005355 DroID - A comprehensive database of gene and protein interactions. • FBgn0005355 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41565 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VG38
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6X982W Dipteran inclusive ortholog search EOG6J9N78 Insect inclusive ortholog search EOG608M4W Arthropod inclusive ortholog search EOG6KPRSR Metazoa inclusive ortholog search EOG6ZD5ZX
Orthologs in Drosophila Species (EOG6X982W)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Su(fu)     Drosophila simulans   Dsim\GD20549 Y   Drosophila sechellia   Dsec\GM25989 Y   Drosophila erecta   Dere\GG17105 Y   Drosophila yakuba   Dyak\GE24494 Y   Drosophila ananassae   Dana\GF17874 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19325 Y   Drosophila persimilis   Dper\GL23115 Y   Drosophila willistoni   Dwil\GK13559 Y   Drosophila virilis   Dvir\Su(fu) Y   Drosophila mojavensis   Dmoj\GI22264 Y   Drosophila grimshawi   Dgri\GH19571 Y
Orthologs in non-Drosophila Dipterans (EOG6J9N78)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003374   Anopheles gambiae Malaria mosquito  Agam\AGAP001948   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001229
Orthologs in non-Dipteran Insects (EOG608M4W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48318   Apis mellifera Western honey bee  Amel\Su(fu)   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020445   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18921   Atta cephalotes Leafcutter ant  Acep\ACEP23778   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12943   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23359   Linepithema humile Argentine ant  Lhum\LH21551   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16713   Solenopsis invicta Red fire ant  Sinv\SINV20418   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007918   Bombyx mori Silkmoth  Bmor\BGIBMGA012178   Pediculus humanus Human body louse  Phum\PHUM452780   Tribolium castaneum Red flour beetle  Tcas\TC000484
Orthologs in non-Insect Arthropods (EOG6KPRSR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_94727   Ixodes scapularis Deer tick  Isca\ISCW022124
Orthologs in non-Arthropod Metazoa (EOG6ZD5ZX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008207gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_001365gn   Danio rerio Zebrafish  Drer\sufu   Xenopus tropicalis Western clawed frog  Xtro\sufu   Gallus gallus Domestic chicken  Ggal\SUFU   Mus musculus House mouse  Mmus\Sufu   Rattus norvegicus Norway rat  Rnor\Sufu   Homo sapiens Human  Hsap\SUFU
Human Orthologs (1)
Gene OMIM HGNC Hsap\SUFU
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20549 Drosophila sechellia Dsec\GM25989 Drosophila erecta Dere\GG17105 Drosophila yakuba Dyak\GE24494 Drosophila ananassae Dana\GF17874 Drosophila pseudoobscura pseudoobscura Dpse\GA19325 Drosophila persimilis Dper\GL23115 Drosophila willistoni Dwil\GK13559 Drosophila virilis Dvir\Su(fu) Drosophila mojavensis Dmoj\GI22264 Drosophila grimshawi Dgri\GH19571
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	21960 w1118; P{EPg}Su(fu)HP31389 22015 w1118; P{EPg}Su(fu)HP37259 28559 y1 v1; P{TRiP.HM05045}attP2
VDRC	v35055 w1118 P{GD11802}v35055
Genomic Clones ( 1 )
	BACR07J06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 45 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM14141
Other clones	DPiM_GM14141
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH05048 GH25220 LD02383 LD05862 LD05923 LD08831 LD11692 LD12767 LD17488 LD19201 LD24112 LD29976 LD30063 LD40994 LD44278 LD45125 LD47177 LD47419 RE17005 RE50585 RE54555 RE55517 RE63466 RE66718 RE67223 RE73986 RH21083 RH30103 RH33217
Other clones	64093 72195 79307 103883 166531 CK01.29D.G10 EK190020 EK201139 EK271128 GH10488 IP12021 IP12121 IP12321 UUGC1090
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005355 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41565
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "c04425" Exelixis line (PBac{PB}Arp87Cc04425) was originally assigned to the Su(fu) gene in FBrf0179797, resulting in the "Su(fu)c04425" (FBal0159716) allele. However, FBrf0184340 shows that the insertion is actually within Arp87C. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
	Su(fu) enters the nucleus in response to hh signaling. (Sisson et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Using the yeast two-hybrid method and an in vitro binding assay it is demonstrated that Su(fu), ci and fu can interact directly to form a trimolecular complex, with Su(fu) binding to both its partners simultaneously. In the absence of hh signalling results propose that Su(fu) inhibits ci by binding to it and that, upon reception of the hh signal, fu is activated and counteracts Su(fu), leading to the activation of ci. (Monnier et al., 1998) Su(fu) and fu modify wing phenotypes due to hh signalling. (Ohlmeyer and Kalderon, 1998) The small lobe of fu may play a role in generating the neomorphic cos phenotype displayed by an unregulated fu protein in a Su(fu)- background. (Alves et al., 1995) Genetic and molecular data suggests that fu and Su(fu) could act through a competitive posttransductional modification of a common target in the hh signalling pathway. (Pham et al., 1995) Alleles of Su(fu) complement alleles of l(3)87Ca, l(3)87Cb, l(3)87Cc and l(3)87Cd, and kar. (Preat, 1992) Mutant Su(fu) embryos can be rescued by P-element mediated transformation of a 4.7kb wild type Su(fu) gene fragment. (Tricoire et al., 1992) Su(fu) suppresses the segment polarity and zygotic phenotype of one class of fu alleles and causes a lethal interaction with the other class of fu alleles. (Preat et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080502 RefSeq (Proteins) • NP_536750 DDBJ / EMBL / GenBank • AA803737 AAA93016 AAF54852 AAL39430 AW941381 AY069285 BAA11929 CAA64954 D83486 U48859 X95652 Entrez Gene - A searchable database of RefSeq genes. • 41565 UniProtKB/TrEMBL • Q9VG38 Q27279
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Suppressor of fused-like (IPR007768) Suppressor of fused protein (IPR016591) Suppressor of fused C-terminal (IPR024314) Suppressor of fused domain (IPR020941) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GM14141
Linkouts
	BioGRID - A database of protein and genetic interactions • 66658 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005355 DroID - A comprehensive database of gene and protein interactions. • FBgn0005355 DRSC - Results from RNAi screens. • FBgn0005355 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005355 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6054-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005355 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205604 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41565 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /segment/sufused1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41565 modMine - Data generated by the modENCODE project. • FBgn0005355 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VG38
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG6054 (Perkins et al., 2009, Anholt and Williams, 2010) Su(fu) (Friggi-Grelin et al., 2008, Ishii, 2005, Briscoe and Therond, 2005, Zhou et al., 2006, Dussillol-Godar et al., 2006, Fouix et al., 2003, Nybakken et al., 2005, Varjosalo et al., 2006, Torroja et al., 2005, Zhou and Kalderon, 2011, Marks and Kalderon, 2011, Toku et al., 2011, Wang and Jiang, 2004, Smelkinson et al., 2007, Walthall et al., 2007, Monnier et al., 2002, Dawber et al., 2005, Methot and Basler, 2000, Wang et al., 2000, Sisson et al., 2006, Pospisilik et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Zhang et al., 2011) su(fu) (Kalderon, 2002, Theil et al., 1999, Tabin and McMahon, 1997) Su(Fu) (Wicking et al., 1999, Walthall et al., 2007) SU(FU) (Plessis et al., 2007, Martin-Lanneree et al., 2006) SuFu (Sherr, 2004, Johnson and Scott, 1997, Zhao et al., 2007, Ayers et al., 2009, Cheng et al., 2012) Sufu (Ruiz i Altaba, 1999, Besse et al., 2002, Monnier et al., 1999, Delattre et al., 1997, Osterlund and Kogerman, 2006, Zhang et al., 2006, Shi et al., 2011, Ayers et al., 2009, Raisin et al., 2010, Farzan et al., 2009) SUFU (Sanial and Plessis, 2007) sufu (Cheng et al., 2012)
Name Synonym	suppressor of fused (Friggi-Grelin et al., 2008, Tricoire, 1996.2.9, Tricoire, 1996.2.13) Suppressor of fused (Plessis et al., 2007, Martin-Lanneree et al., 2006, Zhao et al., 2007, Dawber et al., 2005, Sisson et al., 2006, Farzan et al., 2009) Suppressor of Fused (Sanial and Plessis, 2007, Croker et al., 2006, Torroja et al., 2005, Walthall et al., 2007, Monnier et al., 2002, Ayers et al., 2009, Cheng et al., 2012)
Secondary FlyBase IDs
	FBgn0003562
References ( 165 )
Generate a list of	All references relating to this gene ( 165 )
List References by type	Research paper  ( 64 ) Supplementary material  ( 6 ) Review  ( 40 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 37 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 8 )
	Seong and Ishii, 2013, Genes Cells 18(1): 66--78 Su(fu) switches Rdx functions to fine-tune hedgehog signaling in the Drosophila wing disk. [FBrf0220380] Cheng et al., 2012, Development 139(1): 85--94 Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling. [FBrf0216860] Vied et al., 2012, Dev. Cell 23(4): 836--848 Regulation of stem cells by intersecting gradients of long-range niche signals. [FBrf0219709] Marks and Kalderon, 2011, Development 138(12): 2533--2542 Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation. [FBrf0213757] Shi et al., 2011, Development 138(19): 4219--4231 The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. [FBrf0216910] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Zhang et al., 2011, Cell Res. 21(10): 1436--1451 Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. [FBrf0217260] Zhou and Kalderon, 2011, Dev. Cell 20(6): 802--814 Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. [FBrf0214655] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...