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Gene: Dmel\ash1

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General Information
Symbol
Dmel\ash1
Species
D. melanogaster
Name
absent, small, or homeotic discs 1
Annotation Symbol
CG8887
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005386
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
Histone-lysine N-methyltransferase (2.1.1.43)
Gene Snapshot
absent, small, or homeotic discs 1 (ash1) encodes a histone methyltransferase involved in transcription regulation. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As
ash-1, dash
Key Links
Genomic Location
Cytogenetic map
76B8-76B9
Sequence location
3L:19,590,773..19,598,755 [-]
Recombination map
3-45
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI Genome Data Viewer
UCSC Genome Browser
Ensembl Genome Browser
PopFly Genome Browser
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (Q9VW15)
Protein Domains/Motifs
InterPro
Bromo adjacent homology (BAH) domain; SET domain; Zinc finger, PHD-type; Post-SET domain; AWS domain; Zinc finger, FYVE/PHD-type; Zinc finger, RING/FYVE/PHD-type; Zinc finger, PHD-type, conserved site; Bromodomain-like superfamily
Molecular Function (see GO section for details)
Experimental Evidence
chromatin binding; histone acetyltransferase binding; histone methyltransferase activity; histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); NOT histone methyltransferase activity (H3-K9 specific); NOT histone methyltransferase activity (H4-K20 specific)
Predictions / Assertions
-
Catalytic Activity (EC)
Experimental Evidence
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone] (2.1.1.43)
Predictions / Assertions
-
Summaries
Gene Group Membership
SET DOMAIN LYSINE METHYLTRANSFERASES -
SET domain lysine methyltransferases (KMTs) catalyze the addition of methyl groups to lysine residues. SET domain KMTs possess a domain that was original characterized in the D.mel KMTs Su(var)3-9, E(z) and trx. (Adapted from FBrf0216343).
UniProt Contributed Function Data
Trithorax group (TrxG) protein that has histone methyltransferase activity (PubMed:13679578, PubMed:16882982). Specifically trimethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation (PubMed:13679578, PubMed:16882982). TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specifically prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active (PubMed:15031712).
(UniProt, Q9VW15)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
ash1: absent, small, or homeotic discs
Most alleles homozygous lethal; stage of lethality variable. Surviving and pharate adults display transformations including haltere to wing, first and third legs to second leg, genitalia to leg or antenna; ash18 and ash110 show transformation of posterior to anterior wing margin. Homeotic transformations also seen in clones of homozygous cells in otherwise heterozygous flies. Larvae homozygous for ash112, a severe allele, displays a high incidence of failure to form imaginal disks, especially antennal, genital, haltere, and wing disks.
dash: discs absent, small, or homeotic (A. Shearn)
Homozygotes lethal at prepupal-pupal stage; imaginal discs described as homeotic, with the second leg and the wing discs described as like engrailed. Disc and cell autonomous.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\ash1 or the JBrowse view of Dmel\ash1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.46
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ash1-RB
FBtr0306009
NM_079436
7600
2226
ash1-RC
FBtr0306010
NM_001259905
7615
2226
Additional Transcript Data and Comments
Reported size (kB)
7.5 (northern blot)
(Tripoulas et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ash1-PB
FBpp0297151
246.3
2226
10.19
NP_524160
AAF49140
ash1-PC
FBpp0297152
246.3
2226
10.19
NP_001246834
AFH04505
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2226 aa isoforms: ash1-PB, ash1-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
270 (kD observed)
(Papoulas et al., 1998)
Comments
External Data
Subunit Structure (UniProtKB)
Component of a large multiprotein complex distinct from complexes containing ash2 or brm (PubMed:9735357). Interacts (via SET domain) with trx (via SET domain) (PubMed:10454589, PubMed:10656681). Interacts with nej/cbp (PubMed:11094082).
(UniProt, Q9VW15)
Domain
The SET domain is sufficient for methyltransferase activity.
(UniProt, Q9VW15)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ash1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (23 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
chromatin binding
inferred from direct assay
(Huang et al., 2017)
histone acetyltransferase binding
inferred from physical interaction with FLYBASE:nej; FB:FBgn0261617
(Bantignies et al., 2000)
histone methyltransferase activity
inferred from direct assay
(Huang et al., 2017)
histone methyltransferase activity (H3-K36 specific)
inferred from mutant phenotype
(Dorighi and Tamkun, 2013)
inferred from direct assay
(Huang et al., 2017, Tanaka et al., 2007)
histone methyltransferase activity (H3-K4 specific)
inferred from direct assay
(Byrd and Shearn, 2003)
inferred from mutant phenotype
(Byrd and Shearn, 2003)
NOT histone methyltransferase activity (H3-K9 specific)
inferred from direct assay
(Tanaka et al., 2007)
NOT histone methyltransferase activity (H4-K20 specific)
inferred from direct assay
(Tanaka et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (11 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
chromatin-mediated maintenance of transcription
inferred from mutant phenotype
(LaJeunesse and Shearn, 1995)
embryonic development via the syncytial blastoderm
inferred from mutant phenotype
(Tripoulas et al., 1994)
histone H3-K36 dimethylation
inferred from mutant phenotype
(Dorighi and Tamkun, 2013)
histone H3-K36 methylation
inferred from direct assay
(Huang et al., 2017, Tanaka et al., 2007)
histone H3-K4 methylation
inferred from direct assay
(Byrd and Shearn, 2003)
histone methylation
inferred from direct assay
(Huang et al., 2017)
negative regulation of histone H3-K27 methylation
inferred from mutant phenotype
(Dorighi and Tamkun, 2013)
oogenesis
inferred from mutant phenotype
(Tripoulas et al., 1994)
oviposition
inferred from mutant phenotype
(Tripoulas et al., 1994)
positive regulation of gene expression
inferred from mutant phenotype
(Huang et al., 2017)
regulation of transcription, DNA-templated
inferred from mutant phenotype
(Goodliffe et al., 2007)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
chromatin
inferred from direct assay
(Steffen et al., 2013)
histone methyltransferase complex
inferred from physical interaction with FLYBASE:MRG15; FB:FBgn0027378, FLYBASE:Caf1-55; FB:FBgn0263979
(Huang et al., 2017)
polytene chromosome
inferred from direct assay
(Bantignies et al., 2000)
protein-containing complex
inferred from physical interaction with FLYBASE:nej; FB:FBgn0261617
(Bantignies et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred by curator from GO:0048096
(LaJeunesse and Shearn, 1995)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
blastoderm stage
organism | ubiquitous
(Tripoulas et al., 1994)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Tripoulas et al., 1994)
third instar larval stage
imaginal disc
(Tripoulas et al., 1994)
adult stage & oogenesis
nurse cell
(Tripoulas et al., 1994)
Additional Descriptive Data
ash1 transcripts are present at all stages of development but are less abundant in larvae than in pupae. In ovaries, transcripts are detected in nurse cells and are most abundant in stage 10 egg chambers. ash1 transcripts are detected in preblastoderm and blastoderm embryos and at later stages. In third instar larvae, transcripts are detected in imaginal discs but not in most larval tissues.
(Tripoulas et al., 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
chromatin
inferred from direct assay
(Steffen et al., 2013)
histone methyltransferase complex
inferred from physical interaction with FLYBASE:MRG15; FB:FBgn0027378, FLYBASE:Caf1-55; FB:FBgn0263979
(Huang et al., 2017)
polytene chromosome
inferred from direct assay
(Bantignies et al., 2000)
protein-containing complex
inferred from physical interaction with FLYBASE:nej; FB:FBgn0261617
(Bantignies et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ash1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 44 )
For All Classical and Insertion Alleles Show
 
Allele of ash1
Class
Mutagen
Associated Insertion
Stocks
Known lesion
ash122
amorphic allele - molecular evidence, amorphic allele - genetic evidence
1
Yes
ash1B1
hypomorphic allele - genetic evidence
    2
    Yes
    ash16
    amorphic allele - genetic evidence
    0
    --
    ash117
    antimorphic allele - genetic evidence
    0
    Yes
    ash11
    hypomorphic allele - genetic evidence
    0
    Yes
    ash14
    antimorphic allele - genetic evidence
    0
    Yes
    ash110
    hypomorphic allele - genetic evidence
    0
    Yes
    ash114
    heat sensitive hypomorphic allele - genetic evidence
    0
    Yes
    ash116
    hypomorphic allele - genetic evidence
    0
    Yes
    ash12
    0
    --
    ash111
    hypomorphic allele - genetic evidence
    0
    Yes
    ash121
    hypomorphic allele - genetic evidence
    0
    Yes
    ash129
    hypomorphic allele - genetic evidence
    0
    Yes
    ash112
    0
    --
    ash1MB03235
      1
      Yes
      ash13
      0
      --
      ash15
      0
      --
      ash17
      0
      --
      ash18
      0
      --
      ash19
      0
      --
      ash113
      0
      --
      ash115
      0
      --
      ash118
      0
      --
      ash119
      0
      --
      ash120
      0
      --
      ash123
      0
      --
      ash124
      0
      --
      ash127
      0
      Yes
      ash128
      hypomorphic allele - genetic evidence
      0
      Yes
      ash1AM1
      amorphic allele - genetic evidence
      0
      Yes
      ash1AM2
      amorphic allele - genetic evidence
      0
      Yes
      ash1AM3
      amorphic allele - genetic evidence
      0
      Yes
      ash1AM4
      amorphic allele - genetic evidence
      0
      Yes
      ash125
      0
      Yes
      ash126
      0
      --
      ash1AM5
      hypomorphic allele - genetic evidence
      0
      Yes
      ash1PdL11A3
      0
      Yes
      ash1unspecified
        0
        --
        ash130
        0
        --
        ash131
        0
        --
        ash1B7
          0
          --
          ash1R1288A
          0
          Yes
          ash1Z1369
          0
          --
          ash1Z6088
          0
          --
          Other relevant insertions
          insertion of enhancer trap binary system
          Name
          Expression Data
          PBac{IT.GAL4}1383-G4
          No
          Transgenic Constructs ( 17 )
          For All Alleles Carried on Transgenic Constructs Show
          Transgenic constructs containing/affecting coding region of ash1
          Allele of ash1
          Mutagen
          Associated Transgenic Construct
          Stocks
          ash1GD14059
          1
          ash1JF01498
          1
          ash1HMS00582
          1
          ash1KK100243
          1
          ash1fTRG10044.sfGFP-FT
          1
          ash1GL01012
          1
          ash1JF03430
          1
          ash1sfGFP,Tag:FLAG,Tag:CS(PSP),Tag:CS(TEVp),Tag:BLRP
          1
          ash1TOE.GS02126
          1
          ash1+t9.5
          0
          ash1C.Tag:TAP
          0
          ash1dsRNA.UAS.cUa
          0
          ash1EGFP
          0
          ash1N.Tag:TAP
          0
          ash1R1464A
          0
          ash1UAS.cHa
          0
          ash1αTub84B.EGFP
          0
          Transgenic constructs containing regulatory region of ash1
          Deletions and Duplications ( 29 )
          Summary of Phenotypes
          For more details about a specific phenotype click on the relevant allele symbol.
          Lethality
          Allele
          lethal
          lethal, with Scer\GAL4Act5C.PI
          lethal, with Scer\GAL4en.PU
          lethal (with ash1AM1)
          lethal (with ash1AM2)
          lethal (with ash1AM3)
          lethal (with ash1AM4)
          lethal (with ash1AM5)
          lethal (with Df(3L)Exel9007)
          lethal | heat sensitive
          lethal | late third instar larval stage (with Df(3L)kto2)
          lethal | pharate adult stage (with Df(3L)kto2)
          lethal | pharate adult stage | heat sensitive (with Df(3L)kto2)
          lethal | pupal stage (with Df(3L)kto2)
          lethal | pupal stage | heat sensitive (with Df(3L)kto2)
          lethal | recessive
          lethal | recessive, with Tn10\tetR- :
          lethal | recessive | heat sensitive
          lethal | RU486 conditional, with Tn10\tetRrtTA.Act5C
          lethal - all die before end of larval stage (with Df(3L)Exel9007)
          lethal - all die before end of larval stage | recessive
          lethal - all die before end of prepupal stage | recessive
          lethal - all die before end of P-stage | recessive
          lethal - all die before end of pupal stage (with Df(3L)Exel9007)
          lethal - all die before end of pupal stage | recessive
          lethal - all die during larval stage (with Df(3L)Exel9007)
          partially lethal - majority die, with Scer\GAL4ey.PH
          partially lethal - majority die, with Scer\GAL4pnr-MD237
          viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
          viable, with Scer\GAL4Mef2.PR
          viable, with Scer\GAL4tin.CΔ4
          viable, with Scer\GAL4wor.PA
          Other Phenotypes
          Allele
          enhancer of variegation | dominant, with P{lacW}Dplac
          enhancer of variegation | dominant, with P{lacW}Dplac, gypsy{}ci-E1
          homeotic
          homeotic (with ash122)
          homeotic (with ash1R1288A)
          homeotic | recessive
          non-enhancer of variegation, with P{hsp26-pt-T}39C-5
          non-enhancer of variegation, with P{hsp26-pt-T}39C-27
          non-suppressor of variegation, with P{hsp26-pt-T}39C-5
          non-suppressor of variegation, with P{hsp26-pt-T}39C-27
          short lived | RU486 conditional, with Tn10\tetRrtTA.Act5C
          size defective | adult stage, with Scer\GAL4ey.PH
          some die during larval stage | recessive
          some die during pharate adult stage | recessive
          some die during prepupal stage
          some die during pupal stage, with Scer\GAL4pnr-MD237
          some die during pupal stage | recessive
          suppressor of variegation | dominant, with In(1)wm4
          suppressor of variegation | dominant, with P{wA}4-4
          suppressor of variegation | dominant | female limited, with P{hsp26-pt-T}39C-31
          visible (with ash122)
          visible (with ash1R1288A)
          visible | adult stage, with Scer\GAL4en.PU
          visible | adult stage, with Scer\GAL4ey.PH
          visible | adult stage, with Scer\GAL4nub.PK
          visible | dominant | homeotic
          visible | homeotic
          visible | recessive
          Phenotype manifest in
          Allele
          abdominal segment
          abdominal segment 2 (with ash125)
          abdominal segment 2 (with ash127)
          abdominal segment 6
          abdominal segment 7 | male (with ash125)
          abdominal segment 7 | male (with ash127)
          adult sensillum
          adult sensillum (with ash122)
          adult sensillum (with ash1R1288A)
          eye, with Scer\GAL4ey.PH
          haltere
          haltere disc
          haltere pedicel | adult stage
          haltere pedicel | adult stage (with ash122)
          haltere pedicel | adult stage (with ash1R1288A)
          imaginal disc
          imaginal disc | heat sensitive (with Df(3L)kto2)
          leg sensillum | adult stage | ectopic
          leg sensillum | adult stage | ectopic (with ash122)
          leg sensillum | adult stage | ectopic (with ash1R1288A)
          metathoracic leg | adult stage
          metathoracic leg | adult stage (with ash122)
          metathoracic leg | adult stage (with ash1R1288A)
          metathoracic segment | heat sensitive
          ovary | heat sensitive (with ash11)
          ovary | heat sensitive (with ash114)
          ovary | heat sensitive (with ash128)
          posterior crossvein, with Scer\GAL4en.PU
          posterior crossvein, with Scer\GAL4nub.PK
          wing
          wing, with Scer\GAL4en.PU
          wing | ectopic
          wing blade, with Scer\GAL4nub.PK
          wing posterior compartment, with Scer\GAL4en.PU
          wing vein, with Scer\GAL4en.PU
          Orthologs
          Downloads
          Download All DIOPT Orthologs
          Download All OrthoDB Orthologs
          Human Orthologs (via DIOPT v7.1)
          Homo sapiens (Human) (15)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Source
          Compara
          eggNOG
          Hieranoid
          Homologene
          Inparanoid
          Isobase
          OMA
          OrthoDB
          OrthoFinder
          OrthoInspector
          orthoMCL
          Panther
          Phylome
          RoundUp
          TreeFam
          ZFIN
          Alignment
          Complementation?
          Transgene?
          Hsap\ASH1L
          9 of 15
          Yes
          Yes
          Hsap\SETBP1
          4 of 15
          No
          Yes
          Hsap\DIDO1
          1 of 15
          No
          No
          Hsap\KMT2C
          1 of 15
          No
          No
          Hsap\KMT2D
          1 of 15
          No
          No
          Hsap\KMT2E
          1 of 15
          No
          No
          Hsap\NSD1
          1 of 15
          No
          No
          Hsap\NSD2
          1 of 15
          No
          No
          Hsap\NSD3
          1 of 15
          No
          No
          Hsap\PHF20
          1 of 15
          No
          No
          Hsap\PHF20L1
          1 of 15
          No
          No
          Hsap\SETD1A
          1 of 15
          No
          No
          Hsap\SETD1B
          1 of 15
          No
          No
          Hsap\SETD2
          1 of 15
          No
          No
          Hsap\SETD5
          1 of 15
          No
          No
          Model Organism Orthologs (via DIOPT v7.1)
          Mus musculus (laboratory mouse) (16)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Source
          Compara
          eggNOG
          Hieranoid
          Homologene
          Inparanoid
          Isobase
          OMA
          OrthoDB
          OrthoFinder
          OrthoInspector
          orthoMCL
          Panther
          Phylome
          RoundUp
          TreeFam
          ZFIN
          Alignment
          Complementation?
          Transgene?
          Mmus\Ash1l
          10 of 15
          Yes
          Yes
          Mmus\Setbp1
          3 of 15
          No
          Yes
          Mmus\Dido1
          1 of 15
          No
          No
          Mmus\Kmt2c
          1 of 15
          No
          No
          Mmus\Kmt2d
          1 of 15
          No
          No
          Mmus\Kmt2e
          1 of 15
          No
          No
          Mmus\Nsd1
          1 of 15
          No
          No
          Mmus\Nsd2
          1 of 15
          No
          No
          Mmus\Nsd3
          1 of 15
          No
          No
          Mmus\Phf3
          1 of 15
          No
          No
          Mmus\Phf20l1
          1 of 15
          No
          No
          Mmus\Setd1a
          1 of 15
          No
          No
          Mmus\Setd1b
          1 of 15
          No
          No
          Mmus\Setd2
          1 of 15
          No
          No
          Mmus\Setd5
          1 of 15
          No
          No
          Mmus\Spocd1
          1 of 15
          No
          No
          Rattus norvegicus (Norway rat) (2)
          Rnor\Ash1l
          8 of 13
          Yes
          Yes
          Rnor\Setbp1
          1 of 13
          No
          Yes
          Xenopus tropicalis (Western clawed frog) (1)
          Xtro\setd1b
          1 of 12
          Yes
          No
          Danio rerio (Zebrafish) (11)
          Drer\ash1l
          10 of 15
          Yes
          Yes
          Drer\setbp1
          4 of 15
          No
          Yes
          Drer\kmt2d
          1 of 15
          No
          No
          Drer\kmt2e
          1 of 15
          No
          No
          Drer\nsd1b
          1 of 15
          No
          No
          Drer\nsd2
          1 of 15
          No
          No
          Drer\nsd3
          1 of 15
          No
          No
          Drer\phf3
          1 of 15
          No
          No
          Drer\phf20b
          1 of 15
          No
          No
          Drer\phf20l1
          1 of 15
          No
          No
          Drer\setd1ba
          1 of 15
          No
          No
          Caenorhabditis elegans (Nematode, roundworm) (10)
          Cele\lin-59
          8 of 15
          Yes
          Yes
          Cele\mes-4
          2 of 15
          No
          No
          Cele\C16A11.4
          1 of 15
          No
          No
          Cele\F19B6.3
          1 of 15
          No
          Yes
          Cele\met-1
          1 of 15
          No
          No
          Cele\set-5
          1 of 15
          No
          Yes
          Cele\set-9
          1 of 15
          No
          No
          Cele\set-12
          1 of 15
          No
          No
          Cele\set-16
          1 of 15
          No
          No
          Cele\set-26
          1 of 15
          No
          No
          Arabidopsis thaliana (thale-cress) (0)
          No orthologs reported.
          Saccharomyces cerevisiae (Brewer's yeast) (7)
          Scer\SET2
          2 of 15
          Yes
          No
          Scer\BYE1
          1 of 15
          No
          No
          Scer\CTI6
          1 of 15
          No
          Yes
          Scer\RSC2
          1 of 15
          No
          No
          Scer\SET1
          1 of 15
          No
          No
          Scer\SET3
          1 of 15
          No
          No
          Scer\SET4
          1 of 15
          No
          No
          Schizosaccharomyces pombe (Fission yeast) (5)
          Spom\cti6
          1 of 12
          Yes
          Yes
          Spom\set1
          1 of 12
          Yes
          No
          Spom\set2
          1 of 12
          Yes
          No
          Spom\set3
          1 of 12
          Yes
          No
          Spom\SPCC645.13
          1 of 12
          Yes
          No
          Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900M2 )
          Organism
          Common Name
          Gene
          AAA Syntenic Ortholog
          Multiple Dmel Genes in this Orthologous Group
          Drosophila melanogaster
          fruit fly
          Dmel\ash1
          Drosophila suzukii
          Spotted wing Drosophila
          Dsuz\DS10_00010979
          Drosophila simulans
          Dsim\GD12268
          Drosophila sechellia
          Dsec\GM17444
          Drosophila erecta
          Dere\GG13392
          Drosophila yakuba
          Dyak\GE22484
          Drosophila yakuba
          Dyak\GE22770
          Drosophila yakuba
          Dyak\GE29162
          Drosophila ananassae
          Dana\GF10724
          Drosophila pseudoobscura pseudoobscura
          Dpse\GA21391
          Drosophila persimilis
          Dper\GL20883
          Drosophila willistoni
          Dwil\GK20252
          Drosophila virilis
          Dvir\GJ11874
          Drosophila mojavensis
          Dmoj\GI13513
          Drosophila grimshawi
          Dgri\GH14625
          Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150157 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Musca domestica
          House fly
          Mdoa\17014400
          Glossina morsitans
          Tsetse fly
          Gmor\GMOY005928
          Lucilia cuprina
          Australian sheep blowfly
          Lcup\FF38_06204
          Lucilia cuprina
          Australian sheep blowfly
          Lcup\FF38_09623
          Mayetiola destructor
          Hessian fly
          Mdes\Mdes009322
          Aedes aegypti
          Yellow fever mosquito
          Aaeg\AAEL009666
          Anopheles darlingi
          American malaria mosquito
          Adar\ADAC005034
          Anopheles gambiae
          Malaria mosquito
          Agam\AGAP001535
          Culex quinquefasciatus
          Southern house mosquito
          Cqui\CPIJ001202
          Culex quinquefasciatus
          Southern house mosquito
          Cqui\CPIJ001203
          Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00XX )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Bombyx mori
          Silkmoth
          Bmor\BGIBMGA001497
          Danaus plexippus
          Monarch butterfly
          Dple\DPOGS208029-PA
          Heliconius melpomene
          Postman butterfly
          Hmel\HMEL014602
          Apis florea
          Little honeybee
          Aflo\2478935604
          Apis mellifera
          Western honey bee
          Amel\GB41639
          Bombus impatiens
          Common eastern bumble bee
          Bimp\BIMP12070
          Bombus terrestris
          Buff-tailed bumblebee
          Bter\15207530
          Linepithema humile
          Argentine ant
          Lhum\LH15972
          Megachile rotundata
          Alfalfa leafcutting bee
          Mrot\MROTU:001119
          Nasonia vitripennis
          Parasitic wasp
          Nvit\Nasvi2EG008717
          Dendroctonus ponderosae
          Mountain pine beetle
          Dpod\YQE_08541
          Tribolium castaneum
          Red flour beetle
          Tcas\TC032222
          Pediculus humanus
          Human body louse
          Phum\PHUM244720
          Rhodnius prolixus
          Kissing bug
          Rpro\RPRC001120
          Cimex lectularius
          Bed bug
          Clec\CLEC001585
          Acyrthosiphon pisum
          Pea aphid
          Apim\ACYPI006399
          Zootermopsis nevadensis
          Nevada dampwood termite
          Znev\Znev_16755
          Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00W8 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strigamia maritima
          European centipede
          Smar\SMAR002116
          Ixodes scapularis
          Black-legged tick
          Isca\ISCW005314
          Stegodyphus mimosarum
          African social velvet spider
          Smim\KFM74572.1
          Stegodyphus mimosarum
          African social velvet spider
          Smim\KFM74571.1
          Tetranychus urticae
          Two-spotted spider mite
          Turt\tetur03g02610
          Daphnia pulex
          Water flea
          Dpux\DAPPUDRAFT_39415
          Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02U7 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strongylocentrotus purpuratus
          Purple sea urchin
          Spur\Sp-Ash1
          Ciona intestinalis
          Vase tunicate
          Cint\ash1l
          Gallus gallus
          Domestic chicken
          Ggal\ENSGALG00000014638
          Gallus gallus
          Domestic chicken
          Ggal\Gga.52389
          Human Disease Model Data
          FlyBase Human Disease Model Reports
            Alleles Reported to Model Human Disease (Disease Ontology)
            Download
            Models ( 0 )
            Allele
            Disease
            Evidence
            References
            Interactions ( 2 )
            Allele
            Disease
            Interaction
            References
            ash1B1
            ameliorates  Alzheimer's disease
            modeled by Hsap\MAPTR406W.UAS
            (Frost et al., 2014)
            ash1dsRNA.UAS.cUa
            ameliorates  Alzheimer's disease
            modeled by Hsap\MAPTR406W.UAS
            (Frost et al., 2014)
            Comments ( 0 )
             
            Human Orthologs (via DIOPT v7.1)
            Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
            Homo sapiens (Human)
            Gene name
            Score
            OMIM
            OMIM Phenotype
            Complementation?
            Transgene?
            ASH1L; ASH1 like histone lysine methyltransferase
            9 of 15
            607999
            SETBP1; SET binding protein 1
            4 of 15
            611060
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            ash1|trx
            enhanceable
            Asx
            (Gildea et al., 2000)
            ash1
            suppressible
            Caf1-55::Hsap\MORF4L1
            (Huang et al., 2017)
            ash1
            suppressible
            Caf1-55::MRG15
            (Huang et al., 2017)
            ash1|trx
            suppressible
            dom
            (Ruhf et al., 2001)
            ash1
            suppressible
            dom
            (Ruhf et al., 2001)
            ash1|trx
            enhanceable
            E(Pc)
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            E(z)
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            esc
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            His2Av
            (Swaminathan et al., 2005)
            ash1
            enhanceable
            htt
            (Dietz et al., 2015)
            ash1
            suppressible
            Kdm2
            (Lagarou et al., 2008)
            trx|ash1
            enhanceable
            lawc
            (Zorin et al., 1999)
            trx|ash1
            enhanceable
            lid
            (Gildea et al., 2000)
            trx|ash1
            enhanceable
            mod(mdg4)
            (Gerasimova and Corces, 1998)
            trx|ash1
            enhanceable
            mxc
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            mxc
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            Pc
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            Pcl
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            ph-d
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            pho
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Psc
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            Psc
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Sce
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            Scm
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Scm
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Su(z)2
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Su(z)4
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Su(z)6
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Su(z)7
            (Gildea et al., 2000)
            ash1|trx
            suppressible
            sxc
            (Gildea et al., 2000)
            trx|ash1
            enhanceable
            sxc
            (Gildea et al., 2000)
            ash1|trx
            enhanceable
            Trl
            (Gildea et al., 2000)
            ash1
            enhanceable
            trx
            (McCracken and Locke, 2016)
            mod(mdg4)|ash1
            enhanceable
            trx
            (Gerasimova and Corces, 1998)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            CycE
            enhanceable
            ash1
            (Brumby et al., 2002)
            Dsp1
            enhanceable
            ash1
            (Decoville et al., 2001)
            E(z)
            enhanceable
            ash1
            (Bajusz et al., 2001)
            E(z)
            enhanceable
            ash1|ash2
            (Bajusz et al., 2001)
            gcm
            suppressible
            ash1
            (Popkova et al., 2012)
            lawc
            enhanceable
            ash1|trx
            (Zorin et al., 1999)
            Marcal1
            suppressible
            ash1
            (Morimoto et al., 2016)
            mod(mdg4)
            enhanceable
            ash1|trx
            (Gerasimova and Corces, 1998)
            mod(mdg4)|trx
            enhanceable
            ash1
            (Gerasimova and Corces, 1998)
            nej
            suppressible
            ash1
            (Bantignies et al., 2000)
            Snr1
            enhanceable
            ash1
            (Marenda et al., 2004)
            Snr1
            suppressible
            ash1
            (Marenda et al., 2004)
            trx
            enhanceable
            ash1
            (McCracken and Locke, 2016)
            Ubx
            enhanceable
            ash1
            (LaJeunesse and Shearn, 1995)
            w
            enhanceable
            ash1
            (Rozovskaia et al., 1999)
            External Data
            Subunit Structure (UniProtKB)
            Component of a large multiprotein complex distinct from complexes containing ash2 or brm (PubMed:9735357). Interacts (via SET domain) with trx (via SET domain) (PubMed:10454589, PubMed:10656681). Interacts with nej/cbp (PubMed:11094082).
            (UniProt, Q9VW15 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-45
            Cytogenetic map
            76B8-76B9
            Sequence location
            3L:19,590,773..19,598,755 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            76B8-76B9
            Limits computationally determined from genome sequence between P{EP}MESR6EP3142 and P{lacW}l(3)L3809L3809
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            76B5-76B9
            (determined by in situ hybridisation)
            (Tripoulas and Shearn, 1990)
            Experimentally Determined Recombination Data
            Location
            3-45
            (FlyBase, 2016)
            3-42.8
            (Comeron et al., 2012)
            3-46.6
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (13)
            Genomic Clones (16)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (25)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              polyclonal
              (Schmähling et al., 2018, Huang et al., 2017, Kahn et al., 2016, Riddle et al., 2012)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for identity of: mnd l(3)SG29
              (Shearn, 1995.5.3)
              Source for database merge of
              Source for merge of: l(3)ds5 l(3)SG29
              (Shearn, 1995.5.3)
              Additional comments
              Other Comments
              DNA-protein interactions:GEO_GSE30820 .
              (Sakoparnig et al., 2012)
              The ash1 protein may function to maintain a favorable methylation state of dm targets, allowing subsequent activation by dm protein.
              (Goodliffe et al., 2007)
              ash1 is required for methylation of lysine 4 residues on His3.
              (Byrd and Shearn, 2003)
              Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.
              (Gindhart and Kaufman, 1995)
              ash1 and ash2 are trans-regulatory elements of homeotic selector gene regulation. ash1 is required for the functioning of the Ubx ABX/BX enhancer element, regulation involves different cis-regulatory regions that than of ash1.
              (LaJeunesse and Shearn, 1995)
              The intensity of trx binding to larval salivary gland polytene chromosomes is strongly decreased in larvae carrying mutations in ash1.
              (Kuzin et al., 1994)
              ash1 is one of the trithorax group of genes. ash1 is required in imaginal disc and histoblast derived tissues, and for oogenesis.
              (Tripoulas et al., 1994)
              ash1 gene locus has been characterised.
              (Tripoulas et al., 1992)
              ash1 mutant larvae may have small or absent imaginal discs or express homeotic transformations. ash1 has been isolated and characterised.
              (Tripoulas and Shearn, 1990)
              Genetic tests were used to confirm that ash1 and ash2 belong to a functionally related class of genes, mutations in which cause a wide variety of homeotic transformations that are similar to the transformations caused by trx. Double heterozygotes of ash1 alleles and Df(3R)red-P93 show a significant penetrance of homeotic transformations. Heterozygosity of ash1 alleles increases the penetrance of homeotic transformations in progeny derived from fs(1)h1 hemizygous mothers: the increase in penetrance is proportional to the loss of ash1 function.
              (Shearn, 1989)
              A member of the trithorax group of genes. Encodes a Zinc finger protein required for imaginal disc and histoblast development, and for oogenesis.
              Most alleles homozygous lethal; stage of lethality variable. Surviving and pharate adults display transformations including haltere to wing, first and third legs to second leg, genitalia to leg or antenna;
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 37 )
              Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              InterPro - A database of protein families, domains and functional sites
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Synonyms and Secondary IDs (20)
              Reported As
              Symbol Synonym
              ASH-1
              (Pascual-Garcia et al., 2014)
              ASH1
              (Rybina et al., 2018, L Black et al., 2016, Ho et al., 2014, Kingston and Tamkun, 2014, Mulvey et al., 2014, Di Croce and Helin, 2013, Kockmann et al., 2013, Greer and Shi, 2012, Riddle et al., 2012, Kharchenko et al., 2011, Schuettengruber et al., 2011, Mills, 2010, Blanco et al., 2008, Dorighi et al., 2008, Fanti et al., 2008, Ryakhovskiy and Tillib, 2007, Schwartz and Pirrotta, 2007, Tanaka et al., 2007, Graves and Tamkun, 2006, Lemons and McGinnis, 2006, Dillon et al., 2005, Zhou, 2005, Smith et al., 2004, Coveny et al., 2002, Papoulas et al., 1998)
              Ash
              (Balasov, 2002)
              Ash 1
              (Papp and Muller, 2006)
              Ash1
              (Schmähling et al., 2018, Kang et al., 2017, Kahn et al., 2016, Navarro-Costa et al., 2016, Comoglio and Paro, 2014, Frost et al., 2014, Ost et al., 2014, Sakoparnig et al., 2012, Kirilly et al., 2011, Rodriguez-Jato et al., 2011, Furrer et al., 2010, Eissenberg et al., 2007, Goodliffe et al., 2007, Goodliffe et al., 2007, Li et al., 2007, Prasanth and Spector, 2007, Ringrose and Paro, 2007, Schuettengruber et al., 2007, Bienz, 2006, Ferres-Marco et al., 2006, Lund and van Lohuizen, 2004)
              CG8887
              (Hosono et al., 2015, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008, Bienz, 2006, Klebes et al., 2005, Kim et al., 2004)
              ash
              (Ruhf et al., 2001)
              ash-1
              (DeVido et al., 2008, Zorin et al., 1999, Kim et al., 1998, Gross and McGinnis, 1996, Veraksa and McGinnis, 1996, Fauvarque et al., 1995, Gindhart and Kaufman, 1995, Kapoun and Kaufman, 1995, Kuzin et al., 1994)
              ash1
              (Billmann et al., 2018, Dasari et al., 2018, Ma et al., 2018, Rennie et al., 2018, Rybina et al., 2018, Schmähling et al., 2018, Huang et al., 2017, Sharma et al., 2017, Stessman et al., 2017, Transgenic RNAi Project members, 2017-, McCracken and Locke, 2016, Morimoto et al., 2016, Sarov et al., 2016, Dietz et al., 2015, Ghasemi et al., 2015, Hsu et al., 2015, Kim et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Ugrankar et al., 2015, Frost et al., 2014, Lee and Spradling, 2014, Copur and Müller, 2013, Dorighi and Tamkun, 2013, Kockmann et al., 2013, Lindsley et al., 2013, Petruk et al., 2013, Steffen et al., 2013, Vasanthi et al., 2013, Hainaut et al., 2012, Hallson et al., 2012, Popkova et al., 2012, Sultana et al., 2011, Cooper et al., 2010, Gan et al., 2010, Schwartz et al., 2010, Smulders-Srinivasan et al., 2010, Wasbrough et al., 2010, Fang et al., 2009, Khan et al., 2009, Schaaf et al., 2009, Christensen et al., 2008.4.15, Lagarou et al., 2008, Petruk et al., 2008, Srinivasan et al., 2008, Vázquez et al., 2008, Baeg et al., 2007, Beltran et al., 2007, Carbonell et al., 2007, Chang et al., 2007, Ford et al., 2007, Goodliffe et al., 2007, Goodliffe et al., 2007, Kazemi-Esfarjani et al., 2007, Secombe et al., 2007, Muller and Kassis, 2006, Papp and Muller, 2006, Gim et al., 2001, Tripoulas et al., 1996)
              dash
              (Shishido et al., 1991, Capdevila and Garcia-Bellido, 1981)
              l(3)76BDb
              (Cooper et al., 2010)
              l(3)SG29a
              Name Synonyms
              Absent, small or homeotic 1
              (Kingston and Tamkun, 2014)
              Absent, small or homeotic discs 1
              (Muller and Kassis, 2006)
              Absent, small, or homeotic disc 1
              (Gim et al., 2001)
              absent small or homeotic 1
              (Balasov, 2002)
              absent, small or homeotic discs 1
              (Dorighi and Tamkun, 2013, Beltran et al., 2007, Chang et al., 2007)
              absent, small, or homeotic discs 1
              (Comoglio and Paro, 2014)
              discs absent, small, or homeotic
              discs absent, small, or homeotic-1
              (Tanaka et al., 2007)
              Secondary FlyBase IDs
              • FBgn0000138
              • FBgn0004672
              • FBgn0005228
              Datasets (1)
              Study focus (1)
              Experimental Role
              Project
              Project Type
              Title
              • bait_protein
              modENCODE_chromatin_proteins_cells
              Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
              References (219)