ash-1, absent, small or homeotic discs 1, dash
Please see the JBrowse view of Dmel\ash1 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.46
7.5 (northern blot)
270 (kD observed)
Component of a large multiprotein complex distinct from complexes containing ash2 or brm (PubMed:9735357). Interacts (via SET domain) with trx (via SET domain) (PubMed:10454589, PubMed:10656681). Interacts with nej/cbp (PubMed:11094082).
The SET domain is sufficient for methyltransferase activity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ash1 using the Feature Mapper tool.
ash1 transcripts are present at all stages of development but are less abundant in larvae than in pupae. In ovaries, transcripts are detected in nurse cells and are most abundant in stage 10 egg chambers. ash1 transcripts are detected in preblastoderm and blastoderm embryos and at later stages. In third instar larvae, transcripts are detected in imaginal discs but not in most larval tissues.
GBrowse - Visual display of RNA-Seq signals
View Dmel\ash1 in GBrowse 2Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: mnd l(3)SG29
Source for merge of: l(3)ds5 l(3)SG29
DNA-protein interactions:GEO_GSE30820 .
ash1 gene locus has been characterised.
Genetic tests were used to confirm that ash1 and ash2 belong to a functionally related class of genes, mutations in which cause a wide variety of homeotic transformations that are similar to the transformations caused by trx. Double heterozygotes of ash1 alleles and Df(3R)red-P93 show a significant penetrance of homeotic transformations. Heterozygosity of ash1 alleles increases the penetrance of homeotic transformations in progeny derived from fs(1)h1 hemizygous mothers: the increase in penetrance is proportional to the loss of ash1 function.
A member of the trithorax group of genes. Encodes a Zinc finger protein required for imaginal disc and histoblast development, and for oogenesis.
Most alleles homozygous lethal; stage of lethality variable. Surviving and pharate adults display transformations including haltere to wing, first and third legs to second leg, genitalia to leg or antenna;
