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Gene Dmel\Yp2

General Information
Symbol	Dmel\Yp2	Species	D. melanogaster
Name	Yolk protein 2	Annotation symbol	CG2979
Feature type	protein_coding_gene	FlyBase ID	FBgn0005391
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	YP, fs(1)K313, fs(1)M35
Genomic Location
Chromosome (arm)	X	Recombination map	1-30
Cytogenetic map	9A5-9A5	Sequence location	X:9,944,984..9,946,669 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Yolk protein 2 is referred to in FlyBase by the symbol Dmel\Yp2 (CG2979, FBgn0005391). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural molecule activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 15 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Lipase; Lipase, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult heart, adult fat body, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1623655_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Yp2. Gene sequence location is X:9944984..9946669.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Yp2 Structural gene for the yolk protein YP2 found in recently-emerged female flies. Protein migrates at different rates in SDS-polyacrylamide gels when encoded by the electrophoretic variants Yp2F (fast) and Yp2S (slow), alleles that are female fertile and produce normal amounts of YP2. A mutant Yp2M (=Yp212-1245) is female fertile but lays fewer eggs than normal (Mohler, Postlethwait, and Shirk) and does not contain yolk protein in the hemolymph or ovaries.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 9A5-9A5   Limits computationally determined from genome sequence between P{EP}nejEP1149&P{EP}nejEP1179 and P{EP}α-Man-IEP1628&P{EP}α-Man-IEP1307
Experimentally Determined Cytological Location
Cytogenetic map Notes References 8F-9A   (determined by in situ hybridisation)   (Vieira et al., 1997) 8F-9B   (determined by in situ hybridisation)   (Riddell et al., 1981) 8F-9B   (determined by in situ hybridisation)   (Barnett et al., 1980)
Experimentally Determined Recombination Data
Location	1-30
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Yp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Yp2-RA FBtr0071424  NM_078547   1553   442 Yp2-RB FBtr0339648     1616   442
Additional Transcript Data & Comments
Reported size (kB)	1.67, 1.6 (northern blot) (Hung et al., 1982)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Yp2-PA   FBpp0071359   49.7   442   8.18     NP_511102   AAF46547 Yp2-PB   FBpp0308710   49.7   442   8.18
Additional Polypeptide Data & Comments
Reported size (kDa)	442 (aa); 49.6 (kD predicted) (Hung and Wensink, 1983)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Lipase (IPR000734) Lipase, N-terminal (IPR013818)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567403   AA567631   AA568023   AA697610   AA697796   AA698058   AA698239   AA698360   AA698581   AA698602   AA698720   AA698772   AA698881   AA699019   AA699081   AA699124   AA699155   AA699156   AA736194   AE014298 AAF46547   AI062168   AI062254   AI062489   AI062647   AI062716   AI062786   AI063773   AI063930   AI064475   AI106742   AI106783   AI106830   AI107286   AI107453   AI107643   AI108275   AI108306   AI108311   AI108318   AI108334   AI108395   AI109017   AI109113   AI109237   AI109307   AI109612   AI109944   AI110171   AI113571   AI114406   AI133892   AI134212   AI134265   AI134447   AI134554   AI134707   AI135074   AI135424   AI135452   AI238248   AI238291   AI238310   AI238345   AI238607   AI238684   AI239058   AI292626   AI292711   AI292814   AI293314   AI386719   AI386974   AI387049   AI387056   AI387086   AI387093   AI387128   AI387145   AI387226   AI387422   AI387547   AI387813   AI387997   AI388206   AI388249   AI388343   AI389003   AI389135   AI389136   AI389202   AI389290   AI389434   AI389539   AI402602   AI402640   AI402819   AI402831   AI402880   AI402960   AI403030   AI403038   AI404445   AI404537   AI404862   AI404987   AI405041   AI405298   AI405391   AI405921   AI406024   AI406082   AI513813   AI514279   AI517108   AI517148   AI517250   AI517335   AI517422   AI517625   AI517806   AI518946   AY061042 AAL28590   BG632780   BI563512   BI563530   BI563587   BI563636   BI563659   BI563990   BI564154   BI564293   BI564614   BI565089   BI565180   BI565207   BI565513   BI565573   BI565759   BI565921   BI565933   BI566483   BI566678   BI567664   BI567687   BI567966   BI568256   BI568296   BI569015   BI569016   BI569584   BI569597   BI569984   BI570197   BI570604   BI570718   BI570798   BI571030   BI571057   BI571401   BI572070   BI572132   BI572307   BI572429   BI572573   BI572578   BI572594   BI572612   BI572622   BI572634   BI572639   BI572640   BI573074   BI573153   BI574694   BI574911   BI575181   BI576180   BI576267   BI576446   BI576720   BI581063   BI581064   BI581235   BI581266   BI581475   BI581593   BI581653   BI581694   BI581771   BI581777   BI581817   BI581843   BI581897   BI581991   BI582018   BI582171   BI582384   BI582474   BI582510   BI582519   BI582654   BI582662   BI582853   BI582934   BI583097   BI583153   BI583281   BI583984   BI584490   BI584675   BI585141   BI585695   BI585711   BI586222   BI586270   BI586374   BI587303   BI587554   BI587909   BI588528   BI588571   BI588722   BI588728   BI589455   BI589678   BI589725   BI590155   BI590176   BI590226   BI590349   BI590454   BI590462   BI590723   BI591192   BI591332   BI591371   BI591715   BI591841   BI592024   BI592044   BI592072   BI592415   BI592926   BI592967   BI593129   BI593146   BI593254   BI593260   BI593310   BI593374   BI593450   BI593563   BI593599   BI604410   BI604424   BI604574   BI605059   BI605146   BI605272   BI605904   BI605934   BI606002   BI606029   BI606249   BI606539   BI606574   BI606724   BI606823   BI606988   BI607376   BI607391   BI607398   BI607532   BI607798   BI608147   BI608265   BI608284   BI608652   BI608798   BI609203   BI609259   BI609298   BI609503   BI609724   BI609727   BI609932   BI610877   BI610989   BI611462   BI611949   BI611970   BI612139   BI612153   BI612274   BI612707   BI612833   BI613087   BI613137   BI613316   BI613346   BI613522   BI613927   BI613943   BI614186   BI614297   BI614558   BI614619   BI614659   BI614697   BI614829   BI614925   BI615116   BI615155   BI615291   BI615517   BI615556   BI616227   BI616241   BI616315   BI616358   BI616404   BI617501   BI617574   BI617782   BI618407   BI618710   BI618836   BI618876   BI618888   BI618899   BI619058   BI619160   BI619344   BI619644   BI619800   BI620025   BI620197   BI620264   BI620414   BI620472   BI620562   BI620593   BI620691   BI620822   BI620838   BI620852   BI621122   BI621156   BI621914   BI622052   BI622155   BI622356   BI622388   BI622418   BI622713   BI622730   BI622898   BI623707   BI624219   BI624305   BI624375   BI624606   BI624702   BI624888   BI625038   BI625313   BI625501   BI625742   BI625765   BI625878   BI626081   BI626332   BI627297   BI627540   BI627632   BI627717   BI627941   BI628491   BI628783   BI628881   BI628925   BI628982   BI629014   BI629676   BI629874   BI629914   BI630040   BI630134   BI630216   BI630220   BI630833   BI630894   BI631627   BI631987   BI634597   BI634647   BI634757   BT044481   CO187626   CO190935   CO272786   CO275586   CO278101   CO280815   CO290366   CO294491   CO300135   CO300661   CO304397   CO308962   CO311522   CO313951   CO319445   CO324672   CO325442   CO330094   EC051342   EC057602   EC065326   EC066914   EC067252   EC069858   EC074154   EC078929   EC194997   EC195146   EC197990   EC200224   EC201371   EC205839   EC207037   EC224337   EC225012   EC225626   EC233121   EC237329   EC245282   EC246856   EL870200   EL870385   EL870386   EL874179   EL874192   EL874294   EL876146   EL876147   EV575193   EV575198   EV575210   EV575278   EV575730   EV576056   EV576334   EV576539   EV576636   EV576747   EV576874   EV577069   EV577261   EV577558   EV577790   EV578357   EV578443   EV578519   EV579129   EV579179   EV579349   EV579546   EV579557   EV579635   EV579671   EV579991   EV580081   EV580732   EV580938   EV581165   EV581897   EV581905   EV582022   EV582618   EV582922   EV582963   EV583599   EV583977   EV584053   EV584209   EV584319   EV584416   EV584821   EV585061   EV585282   EV585597   EV585870   EV586635   EV586799   EV587697   EV588026   EV588227   EV588248   EV588567   EV588695   EV589201   EV589311   EV589329   EV590299   EV590545   EV590836   EV591015   EV591017   EV591190   EV591882   EV592341   EV593227   EV596020   EV597195   EV597772   EV599198   EV599916   L14421   L14422   L14423   X01524 CAA25710
UniProtKB/Swiss-Prot	P02844
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 07022 07023
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
NOT ACF complex inferred from direct assay (Ito et al., 1999) lipid particle inferred from direct assay (Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
Reporter: P{Yp2.M13.G1}P{Yp1.M13.L1} Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   ovary   (Garabedian et al., 1985) Reporter: P{Yp2.M13.G1}P{Yp1.M13.L1} Stage Tissue/Position (including subcellular localization) Reference oogenesis & adult stage | female   ovary   (Garabedian et al., 1985)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, adult hindgut, adult heart, adult fat body, adult female reproductive system, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head    5771.2 Adult Eye    6134.55 Adult Brain    1232.6 Adult Thoracic-Abdominal Ganglion    1797.2 Adult Crop    1191.2 Adult Midgut    43.6 Adult Hindgut    2816.5 Adult Malpighian Tubules    898.8 Adult Fat Body    4427.3 Adult Salivary Gland    306.5 Adult Heart    7328.175 Adult VirginFemale Spermatheca    4427 Adult InseminatedFemale Spermatheca    4716.9 Adult Ovary    2686.3 Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass    7551.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head  (5771.2) Adult Eye  (6134.55) Adult Brain  (1232.6) Adult Thoracic-Abdominal Ganglion  (1797.2) Adult Crop  (1191.2) Adult Midgut    43.6 Adult Hindgut  (2816.5) Adult Malpighian Tubules  (898.8) Adult Fat Body  (4427.3) Adult Salivary Gland    306.5 Adult Heart  (7328.175) Adult VirginFemale Spermatheca  (4427) Adult InseminatedFemale Spermatheca  (4716.9) Adult Ovary  (2686.3) Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass  (7551.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head  (5771.2) Adult Eye  (6134.55) Adult Brain  (1232.6) Adult Thoracic-Abdominal Ganglion  (1797.2) Adult Crop  (1191.2) Adult Midgut    43.6 Adult Hindgut  (2816.5) Adult Malpighian Tubules    898.8 Adult Fat Body  (4427.3) Adult Salivary Gland    306.5 Adult Heart  (7328.175) Adult VirginFemale Spermatheca  (4427) Adult InseminatedFemale Spermatheca  (4716.9) Adult Ovary  (2686.3) Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass  (7551.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head    5771.2 Adult Eye    6134.55 Adult Brain    1232.6 Adult Thoracic-Abdominal Ganglion    1797.2 Adult Crop    1191.2 Adult Midgut    43.6 Adult Hindgut    2816.5 Adult Malpighian Tubules    898.8 Adult Fat Body    4427.3 Adult Salivary Gland    306.5 Adult Heart    7328.175 Adult VirginFemale Spermatheca    4427 Adult InseminatedFemale Spermatheca    4716.9 Adult Ovary    2686.3 Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass    7551.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head    5771.2 Adult Eye    6134.55 Adult Brain    1232.6 Adult Thoracic-Abdominal Ganglion    1797.2 Adult Crop    1191.2 Adult Midgut    43.6 Adult Hindgut    2816.5 Adult Malpighian Tubules    898.8 Adult Fat Body    4427.3 Adult Salivary Gland    306.5 Adult Heart    7328.175 Adult VirginFemale Spermatheca    4427 Adult InseminatedFemale Spermatheca    4716.9 Adult Ovary    2686.3 Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass    7551.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head  (5771.2) Adult Eye  (6134.55) Adult Brain  (1232.6) Adult Thoracic-Abdominal Ganglion  (1797.2) Adult Crop  (1191.2) Adult Midgut    43.6 Adult Hindgut  (2816.5) Adult Malpighian Tubules  (898.8) Adult Fat Body  (4427.3) Adult Salivary Gland    306.5 Adult Heart  (7328.175) Adult VirginFemale Spermatheca  (4427) Adult InseminatedFemale Spermatheca  (4716.9) Adult Ovary  (2686.3) Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass  (7551.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head  (5771.2) Adult Eye  (6134.55) Adult Brain  1232.6 Adult Thoracic-Abdominal Ganglion  (1797.2) Adult Crop  1191.2 Adult Midgut    43.6 Adult Hindgut  (2816.5) Adult Malpighian Tubules    898.8 Adult Fat Body  (4427.3) Adult Salivary Gland    306.5 Adult Heart  (7328.175) Adult VirginFemale Spermatheca  (4427) Adult InseminatedFemale Spermatheca  (4716.9) Adult Ovary  (2686.3) Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass  (7551.6) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.4 Larval Midgut    33.6 Larval Hindgut    10.5 Larval Malpighian Tubules    3.9 Larval Fat Body    26 Larval Salivary Gland    3.4 Larval Trachea    183.075 Larval Carcass    3.475 Adult Head    5771.2 Adult Eye    6134.55 Adult Brain    1232.6 Adult Thoracic-Abdominal Ganglion    1797.2 Adult Crop    1191.2 Adult Midgut    43.6 Adult Hindgut    2816.5 Adult Malpighian Tubules    898.8 Adult Fat Body    4427.3 Adult Salivary Gland    306.5 Adult Heart    7328.175 Adult VirginFemale Spermatheca    4427 Adult InseminatedFemale Spermatheca    4716.9 Adult Ovary    2686.3 Adult Testis    1.2 Adult Male Accessory Gland    17.6 Adult Carcass    7551.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    5771.2   NA  Eye    6134.55   NA  Brain    1232.6   7.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1797.2   NA  Crop    1191.2   no informative data  Midgut    43.6   no informative data  Hindgut    2816.5   3.9  Malpighian Tubules    no informative data   no informative data  Fat Body    4427.3   3.4  Salivary Gland    306.5   NA  Heart    7328.175   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    4427   NA  InseminatedFemale Spermatheca    4716.9   NA  Ovary    2686.3   NA  Testis    1.2   NA  Male Accessory Gland    no informative data   3.475  Carcass    7551.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female    13200 head, virgin 4-day female    14317 head, virgin 20-day female    38631 head, mated 1-day female    13600 head, mated 4-day female    19798 head, mated 20-day female    41449 head, mated 1-day male    37 head, mated 4-day male    123 head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    36 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    946 digestive system, 4-day adult    1014 digestive system, 20-day adult    1002 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    67 carcass, larvae L3 wandering    344 carcass, 1-day adult    15042 carcass, 4-day adult    17819 carcass, 20-day adult    25327 ovary, virgin 4-day female    821 ovary, mated 4-day female    919 testis, mated 4-day male    9 accessory gland, mated 4-day male    29 Expression Level Scale  Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female  (13200) head, virgin 4-day female  (14317) head, virgin 20-day female  (38631) head, mated 1-day female  (13600) head, mated 4-day female  (19798) head, mated 20-day female  (41449) head, mated 1-day male  (37) head, mated 4-day male  (123) head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae  (36) digestive system, larvae L3 wandering    3 digestive system, 1-day adult  (946) digestive system, 4-day adult  (1014) digestive system, 20-day adult  (1002) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8  (67) carcass, larvae L3 wandering  (344) carcass, 1-day adult  (15042) carcass, 4-day adult  (17819) carcass, 20-day adult  (25327) ovary, virgin 4-day female  (821) ovary, mated 4-day female  (919) testis, mated 4-day male    9 accessory gland, mated 4-day male  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female  (13200) head, virgin 4-day female  (14317) head, virgin 20-day female  (38631) head, mated 1-day female  (13600) head, mated 4-day female  (19798) head, mated 20-day female  (41449) head, mated 1-day male    37 head, mated 4-day male  (123) head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    36 digestive system, larvae L3 wandering    3 digestive system, 1-day adult  (946) digestive system, 4-day adult  (1014) digestive system, 20-day adult  (1002) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    67 carcass, larvae L3 wandering  (344) carcass, 1-day adult  (15042) carcass, 4-day adult  (17819) carcass, 20-day adult  (25327) ovary, virgin 4-day female  (821) ovary, mated 4-day female  (919) testis, mated 4-day male    9 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female    13200 head, virgin 4-day female    14317 head, virgin 20-day female    38631 head, mated 1-day female    13600 head, mated 4-day female    19798 head, mated 20-day female    41449 head, mated 1-day male    37 head, mated 4-day male    123 head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    36 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    946 digestive system, 4-day adult    1014 digestive system, 20-day adult    1002 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    67 carcass, larvae L3 wandering    344 carcass, 1-day adult    15042 carcass, 4-day adult    17819 carcass, 20-day adult    25327 ovary, virgin 4-day female    821 ovary, mated 4-day female    919 testis, mated 4-day male    9 accessory gland, mated 4-day male    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female    13200 head, virgin 4-day female    14317 head, virgin 20-day female    38631 head, mated 1-day female    13600 head, mated 4-day female    19798 head, mated 20-day female    41449 head, mated 1-day male    37 head, mated 4-day male    123 head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    36 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    946 digestive system, 4-day adult    1014 digestive system, 20-day adult    1002 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    67 carcass, larvae L3 wandering    344 carcass, 1-day adult    15042 carcass, 4-day adult    17819 carcass, 20-day adult    25327 ovary, virgin 4-day female    821 ovary, mated 4-day female    919 testis, mated 4-day male    9 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female  (13200) head, virgin 4-day female  (14317) head, virgin 20-day female  (38631) head, mated 1-day female  (13600) head, mated 4-day female  (19798) head, mated 20-day female  (41449) head, mated 1-day male  (37) head, mated 4-day male  (123) head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae  (36) digestive system, larvae L3 wandering    3 digestive system, 1-day adult  (946) digestive system, 4-day adult  (1014) digestive system, 20-day adult  (1002) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8  (67) carcass, larvae L3 wandering  (344) carcass, 1-day adult  (15042) carcass, 4-day adult  (17819) carcass, 20-day adult  (25327) ovary, virgin 4-day female  (821) ovary, mated 4-day female  (919) testis, mated 4-day male    9 accessory gland, mated 4-day male  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female  (13200) head, virgin 4-day female  (14317) head, virgin 20-day female  (38631) head, mated 1-day female  (13600) head, mated 4-day female  (19798) head, mated 20-day female  (41449) head, mated 1-day male    37 head, mated 4-day male  123 head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    36 digestive system, larvae L3 wandering    3 digestive system, 1-day adult  (946) digestive system, 4-day adult  (1014) digestive system, 20-day adult  (1002) fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    67 carcass, larvae L3 wandering  (344) carcass, 1-day adult  (15042) carcass, 4-day adult  (17819) carcass, 20-day adult  (25327) ovary, virgin 4-day female  (821) ovary, mated 4-day female  (919) testis, mated 4-day male    9 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    0 central nervous system, pupae P8    23 head, virgin 1-day female    13200 head, virgin 4-day female    14317 head, virgin 20-day female    38631 head, mated 1-day female    13600 head, mated 4-day female    19798 head, mated 20-day female    41449 head, mated 1-day male    37 head, mated 4-day male    123 head, mated 20-day male    2 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    36 digestive system, larvae L3 wandering    3 digestive system, 1-day adult    946 digestive system, 4-day adult    1014 digestive system, 20-day adult    1002 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    67 carcass, larvae L3 wandering    344 carcass, 1-day adult    15042 carcass, 4-day adult    17819 carcass, 20-day adult    25327 ovary, virgin 4-day female    821 ovary, mated 4-day female    919 testis, mated 4-day male    9 accessory gland, mated 4-day male    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day    42 adult male 30day    1 adult female 01day    4404 adult female 05day    8877 adult female 30day    8677 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day  (42) adult male 30day    1 adult female 01day  (4404) adult female 05day  (8877) adult female 30day  (8677) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day    42 adult male 30day    1 adult female 01day  (4404) adult female 05day  (8877) adult female 30day  (8677) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day    42 adult male 30day    1 adult female 01day    4404 adult female 05day    8877 adult female 30day    8677 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day    42 adult male 30day    1 adult female 01day    4404 adult female 05day    8877 adult female 30day    8677 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day  (42) adult male 30day    1 adult female 01day  (4404) adult female 05day  (8877) adult female 30day  (8677) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day    42 adult male 30day    1 adult female 01day  (4404) adult female 05day  (8877) adult female 30day  (8677) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    0 embryo 20-22hr    0 embryo 22-24hr    0 larva L1    0 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    2 pupae 3d postWPP    0 pupae 4d postWPP    7 adult male 01day    20 adult male 05day    42 adult male 30day    1 adult female 01day    4404 adult female 05day    8877 adult female 30day    8677 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    1 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2559 cold shock, 4-day adult    2772 heat shock, 4-day adult    2593 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    210 Zinc 5 mM 12 hrs, larvae L3    256 Zinc 4.5 mM 48 hrs, 4-day adult    607 Ethanol 2.5% 3 hrs, larvae L3    2163 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    314 Caffeine 25 mg/ml 48 hrs, 4-day adult    2336 Paraquat 5 mM 48 hrs, 4-day adult    910 Paraquat 10 mM 48 hrs, 4-day adult    1649 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (2559) cold shock, 4-day adult  (2772) heat shock, 4-day adult  (2593) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult  (42) Cadmium 100 mM 48 hrs, 4-day adult  (68) Copper 0.5 mM 12 hrs, larvae L3  (38) Copper 15 mM 48 hrs, 4-day adult  (210) Zinc 5 mM 12 hrs, larvae L3  (256) Zinc 4.5 mM 48 hrs, 4-day adult  (607) Ethanol 2.5% 3 hrs, larvae L3  (2163) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (314) Caffeine 25 mg/ml 48 hrs, 4-day adult  (2336) Paraquat 5 mM 48 hrs, 4-day adult  (910) Paraquat 10 mM 48 hrs, 4-day adult  (1649) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (2559) cold shock, 4-day adult  (2772) heat shock, 4-day adult  (2593) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult  (210) Zinc 5 mM 12 hrs, larvae L3  (256) Zinc 4.5 mM 48 hrs, 4-day adult  (607) Ethanol 2.5% 3 hrs, larvae L3  (2163) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (314) Caffeine 25 mg/ml 48 hrs, 4-day adult  (2336) Paraquat 5 mM 48 hrs, 4-day adult  (910) Paraquat 10 mM 48 hrs, 4-day adult  (1649) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2559 cold shock, 4-day adult    2772 heat shock, 4-day adult    2593 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    210 Zinc 5 mM 12 hrs, larvae L3    256 Zinc 4.5 mM 48 hrs, 4-day adult    607 Ethanol 2.5% 3 hrs, larvae L3    2163 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    314 Caffeine 25 mg/ml 48 hrs, 4-day adult    2336 Paraquat 5 mM 48 hrs, 4-day adult    910 Paraquat 10 mM 48 hrs, 4-day adult    1649 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2559 cold shock, 4-day adult    2772 heat shock, 4-day adult    2593 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    210 Zinc 5 mM 12 hrs, larvae L3    256 Zinc 4.5 mM 48 hrs, 4-day adult    607 Ethanol 2.5% 3 hrs, larvae L3    2163 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    314 Caffeine 25 mg/ml 48 hrs, 4-day adult    2336 Paraquat 5 mM 48 hrs, 4-day adult    910 Paraquat 10 mM 48 hrs, 4-day adult    1649 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (2559) cold shock, 4-day adult  (2772) heat shock, 4-day adult  (2593) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult  (42) Cadmium 100 mM 48 hrs, 4-day adult  (68) Copper 0.5 mM 12 hrs, larvae L3  (38) Copper 15 mM 48 hrs, 4-day adult  (210) Zinc 5 mM 12 hrs, larvae L3  (256) Zinc 4.5 mM 48 hrs, 4-day adult  (607) Ethanol 2.5% 3 hrs, larvae L3  (2163) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (314) Caffeine 25 mg/ml 48 hrs, 4-day adult  (2336) Paraquat 5 mM 48 hrs, 4-day adult  (910) Paraquat 10 mM 48 hrs, 4-day adult  (1649) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (2559) cold shock, 4-day adult  (2772) heat shock, 4-day adult  (2593) Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult  (210) Zinc 5 mM 12 hrs, larvae L3  (256) Zinc 4.5 mM 48 hrs, 4-day adult  (607) Ethanol 2.5% 3 hrs, larvae L3  (2163) Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (314) Caffeine 25 mg/ml 48 hrs, 4-day adult  (2336) Paraquat 5 mM 48 hrs, 4-day adult  (910) Paraquat 10 mM 48 hrs, 4-day adult  (1649) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2559 cold shock, 4-day adult    2772 heat shock, 4-day adult    2593 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    42 Cadmium 100 mM 48 hrs, 4-day adult    68 Copper 0.5 mM 12 hrs, larvae L3    38 Copper 15 mM 48 hrs, 4-day adult    210 Zinc 5 mM 12 hrs, larvae L3    256 Zinc 4.5 mM 48 hrs, 4-day adult    607 Ethanol 2.5% 3 hrs, larvae L3    2163 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    314 Caffeine 25 mg/ml 48 hrs, 4-day adult    2336 Paraquat 5 mM 48 hrs, 4-day adult    910 Paraquat 10 mM 48 hrs, 4-day adult    1649 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	BDGP expression data • HL08149 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2979-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Yp2GD16521 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Yp2GD16521 viable Yp2e03312 viable, with Scer\GAL4pnr-MD237 Yp2GD6467 Sterility Allele fertile Yp2e03312 Other Phenotypes Allele electrophoretic variant Yp2F Yp2S neuroanatomy defective | larval stage Yp2GD16521 visible, with Scer\GAL4pnr-MD237 Yp2GD16521 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage Yp2GD16521 ganglion mother cell | larval stage Yp2GD16521 mesothoracic tergum, with Scer\GAL4pnr-MD237 Yp2GD16521
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Yp2 Class Mutagen Stocks Known lesion Yp2e03312 piggyBac transposase 2 -- Yp2M amorphic allele - genetic evidence 0 -- Yp2F natural population 0 -- Yp2K313 0 Yes Yp2S natural population 0 -- Yp2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Yp2 Class Mutagen Stocks Known lesion Yp2GD16521 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Yp2GD6467 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Yp2-159-340.T:M13\M13 in vitro construct - deletion 0 Yes Yp2-159.T:M13\M13 in vitro construct - deletion 0 Yes Yp2-164+4.T:M13\M13 in vitro construct - deletion 0 Yes Yp2-342.T:M13\M13 in vitro construct - coding region fusion 0 Yes Yp2430.T:Scer\SUC2 in vitro construct - coding region fusion 0 Yes Yp2Yp1.T:M13\M13 in vitro construct - coding region fusion in vitro construct 0 Yes Yp2yp2.2.0 in vitro construct - genomic fragment in vitro construct 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(1)su(s)83 (Voelker et al., 1989)
Disrupted in	Df(1)C52 (Bownes et al., 1991, Butterworth et al., 1992, Giorgi et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{CR1} No P{CR1sub3} No P{CR2} No P{yp1del} No P{Yp1-lacZ.G1} No P{Yp1-lacZ.G2} No P{Yp1-lacZ.G3} No P{Yp1-lacZ.G4a} No P{Yp1-lacZ.G4b} No P{Yp1-lacZ.G5a} No P{Yp1-lacZ.G5b} No P{Yp1-lacZ.L1a} No P{Yp1-lacZ.L1b} No P{Yp1-lacZ.L2a} No P{Yp1-lacZ.L2b} No P{Yp1-lacZ.L3} No P{Yp1-lacZ.L4a} No P{Yp1-lacZ.L4b} No P{Yp1-lacZ.L5} No P{Yp1-lacZ.L6} No P{Yp2-lacZ.FBE1.3-R1} No P{Yp2-lacZ.FBE1.3-R3} No P{Yp2-lacZ.FBE1.3-R3sR3} No P{Yp2-lacZ.FBE1.3-R3ssR3} No P{Yp2-lacZ.FBE1.3-R3sssR3} No P{Yp2-lacZ.FBE1.3-R4} No P{Yp2-lacZ.FBE1.3-R6} No P{Yp2-lacZ.FBE1.ctrl} No P{Yp2-lacZ.FBE1.Mega-ctrl} No P{Yp2-lacZ.FBE1.Mega-R3sR3} No P{Yp2-lacZ.FBE1.Mega-R6} No P{Yp2-lacZ.FBE1.Mega-REP} No P{Yp2-lacZ.FBE1.REP} No UAS construct P{GD6467} NA P{GD16521} NA characterization construct P{YP1,2;wAFP2:YP1-3'} NA P{YP1,2;wAFP2} NA P{YP1,2:wAFP:IVS} NA P{YP1,2:wAFP:ΔIVS} NA P{Yp2.M13.G1} NA P{Yp2.M13.L1} NA P{Yp2.M13.L2} NA P{Yp2.p} NA P{Yp2-SUC2} NA P{Yp(1+2)M13} NA P{Yp(1+2)M13Δ1} NA P{Yp(1+2)M13Δ2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Yp2e03312 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
NOT ACF complex inferred from direct assay (Ito et al., 1999) lipid particle inferred from direct assay (Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
catalytic activity inferred from electronic annotation with InterPro:IPR000734 (FlyBase Curators et al., 2004-) structural molecule activity inferred from sequence or structural similarity with UniProtKB:P27878 (FlyBase, 1992-)
Biological Process
CV term Evidence References
lipid metabolic process inferred from electronic annotation with InterPro:IPR000734 (FlyBase Curators et al., 2004-) oogenesis traceable author statement (Perrimon et al., 1986) sex differentiation non-traceable author statement (Schutt and Nothiger, 2000) traceable author statement (Christiansen et al., 2002) vitellogenesis non-traceable author statement (Swiss-Prot Project Members, 1986.7.21)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Yp2 - Adh experimental knowledge based (Guruharsha et al., 2011) Yp2 - Ald experimental knowledge based (Guruharsha et al., 2011) Yp2 - Argk experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG16826 experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG16885 experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG31198 experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG31343 experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG32473 experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG34205 experimental knowledge based (Guruharsha et al., 2011) Yp2 - CG5500 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Yp2 - CG5506 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Cat experimental knowledge based (Guruharsha et al., 2011) Yp2 - Fer2LCH experimental knowledge based (Guruharsha et al., 2011) Yp2 - Gapdh2 experimental knowledge based (Guruharsha et al., 2011) Yp2 - GlyP experimental knowledge based (Guruharsha et al., 2011) Yp2 - Gpdh experimental knowledge based (Guruharsha et al., 2011) Yp2 - Lsp2 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Pgk experimental knowledge based (Guruharsha et al., 2011) Yp2 - Pglym78 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Rab11 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Rfabg experimental knowledge based (Guruharsha et al., 2011) Yp2 - Scp1 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Tsf1 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Yp1 experimental knowledge based (Guruharsha et al., 2011) Yp2 - Yp3 experimental knowledge based (Guruharsha et al., 2011) Yp2 - proPO-A1 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Yp2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58374 DroID - A comprehensive database of gene and protein interactions. • FBgn0005391 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31938
Orthologs
OrthoDB Orthologs (11) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG63N7ZR Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG63N7ZR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Yp2     Drosophila simulans   Dsim\Yp2 Y   Drosophila sechellia   Dsec\Yp2 Y   Drosophila erecta   Dere\GG18948 Y   Drosophila yakuba   Dyak\GE15420 Y   Drosophila ananassae   Dana\GF19151 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA22302 Y   Drosophila willistoni   Dwil\GK25110 Y   Drosophila virilis   Dvir\GJ19423 Y   Drosophila mojavensis   Dmoj\GI14609     Drosophila grimshawi   Dgri\Yp2 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\Yp2 Drosophila sechellia Dsec\Yp2 Drosophila erecta Dere\GG18948 Drosophila yakuba Dyak\GE15420 Drosophila ananassae Dana\GF19151 Drosophila pseudoobscura pseudoobscura Dpse\GA22302 Drosophila willistoni Dwil\GK25110 Drosophila virilis Dvir\GJ19423 Drosophila grimshawi Dgri\Yp2
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	18146 w1118 PBac{RB}Yp2e03312
Harvard	- PBac{RB}Yp2e03312
VDRC	v30859 w1118; P{GD6467}v30859 v30862 w1118; P{GD6467}v30862 v50156 w1118; P{GD16521}v50156 v50157 w1118; P{GD16521}v50157/TM3
Genomic Clones ( 1 )
	BACR07L06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 511 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	HL08149
Other clones	TA01815
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01275 GH01401 GH01932 GH02021 GH02121 GH03747 GH04050 GH05436 GH06065 GH07073 GH07116 GH07121 GH07149 GH07221 GH07513 GH08368 GH08451 GH08850 GH09351 GH09672 GH09918 GH10688 GH11606 GH11675 GH11918 GH12047 GH12695 GH13176 GH13230 GH14262 GH14311 GH14373 GH14684 GH14773 GH15228 GH15674 GH15815 GH16895 GH17373 GH17474 GH17481 GH17518 GH17570 GH17588 GH17686 GH17947 GH18104 GH18474 GH19027 GH19077 GH19213 GH20230 GH20231 GH20320 GH20428 GH20747 GH21894 GH22118 GH22135 GH22210 GH22306 GH22385 GH24163 GH24285 GH24708 GH24876 GH25253 GH25376 GH26074 GH26209 GH26282 GH26913 GH27375 GH27744 GH27793 GH27930 GH28356 GH28659 GH28868 HL02166 HL03702 HL04003 HL04339 HL04964 HL07431 RH34156 RH38844 RH42686 RH43505 RH48218 RH57528 RH57644 RH58853 RH59214 RH60234 RH64607 RH66615 RH67020 RH68567 RH68884 RH68989 RH69103
Other clones	10536 17136 42118 57348 57717 69448 74659 75081 97232 106699 107996 108644 173855 181840 192158 CK01.3A.F3 CK01.29C.E4 CK01.34B.E9 CK01.36B.C2 CK01.62B.G8 CK01.75D.F10 Dmel_dig_001050_0607_0516 Dmel_dig_001447_0634_3779 Dmel_dig_001873_0645_2327 Dmel_dig_002270_0588_2453 Dmel_dig_002715_0593_3612 Dmel_dig_002841_0634_0354 Dmel_dig_002920_0652_0623 Dmel_dig_003013_0586_1372 Dmel_dig_003702_0600_1960 Dmel_dig_003992_0612_3042 Dmel_dig_004901_0599_0549 Dmel_dig_005173_0628_3191 Dmel_dig_005465_0597_1509 Dmel_dig_005836_0700_0612 Dmel_dig_005932_0657_1776 Dmel_dig_006627_0709_2630 Dmel_dig_006645_0654_2616 Dmel_dig_007623_0702_2336 Dmel_dig_008694_0702_0859 Dmel_dig_009166_0610_0330 Dmel_dig_009515_0683_2916 Dmel_dig_009920_0602_1466 Dmel_dig_010341_0639_0466 Dmel_dig_010363_0653_1521 Dmel_dig_010394_0668_2233 Dmel_dig_010455_0622_1945 Dmel_dig_010873_0601_0683 Dmel_dig_011415_0671_1836 Dmel_dig_011518_0590_1210 Dmel_dig_011609_0585_1989 Dmel_dig_012305_0696_3070 Dmel_dig_012981_0656_2151 Dmel_dig_013059_0622_0965 Dmel_dig_013066_0712_2527 Dmel_dig_013068_0621_1854 Dmel_dig_014868_0623_1224 Dmel_dig_015330_0716_1351 Dmel_dig_015460_0726_0550 Dmel_dig_015786_0630_3496 Dmel_dig_016028_0711_2995 Dmel_dig_018104_0619_2851 Dmel_dig_018318_0674_2766 Dmel_dig_019049_0716_1751 Dmel_dig_019553_0627_1308 Dmel_dig_019715_0714_2423 Dmel_dig_019838_0606_1109 Dmel_dig_020491_0667_2102 Dmel_neb_000764_0167_3712 Dmel_neb_001458_0343_3721 Dmel_neb_005253_0651_0350 Dmel_neb_006015_0945_3315 Dmel_neb_008307_0596_1954 Dmel_neb_008890_0191_0741 Dmel_neb_009634_0685_1937 Dmel_neb_009945_0867_1444 Dmel_neb_011334_0445_1474 Dmel_neb_011944_0156_0973 Dmel_neb_012414_0339_1404 Dmel_neb_013140_0827_0908 Dmel_neb_013273_0181_2282 Dmel_neb_013310_0347_0617 Dmel_neb_013326_0946_1842 Dmel_neb_013780_0363_1453 Dmel_neb_014459_0439_1529 Dmel_neb_014719_0188_3258 Dmel_neb_014966_0351_1393 Dmel_neb_014983_0331_2630 Dmel_neb_015190_0409_1793 Dmel_neb_015324_0088_0586 Dmel_neb_015487_0165_1952 Dmel_neb_015496_0160_1448 Dmel_neb_015686_0317_3585 EC051342 EK030931 EK050143 EK073802 EK108408 EK117963 EK128749 EK154932 EK177450 EK178934 EK194506 EK196526 EK207050 EK225006 EK234354 EK244604 EK259805 EK278139 EK294523 GH01712 GH01851 GH03833 GH03860 GH04913 GH05144 GH06001 GH07132 GH07674 GH12241 GH13769 GH14333 GH15570 GH16483 GH17526 GH18722 GH20072 GH20608 GH21851 GH22394 GH24949 GH28049 HL01135 HL01555 HL02866 HL03174 HL05317 HL05554 HL05665 HL05854 HL07319 HL07746 HL07810 HL07812 IP02301 IP02481 IP05994 IP14216 IP14227 IP14316 RH01075 RH01240 RH01683 RH01696 RH02203 RH02478 RH03149 RH03203 RH03737 RH03760 RH03818 RH03956 RH04076 RH04085 RH04382 RH04923 RH05084 RH05135 RH05363 RH05489 RH05581 RH05839 RH05867 RH06420 RH06585 RH07410 RH07479 RH07634 RH07788 RH07940 RH08128 RH08136 RH08161 RH08193 RH08208 RH08222 RH08231 RH08233 RH08770 RH08869 RH09620 RH09646 RH09686 RH10090 RH10751 RH10810 RH11059 RH11082 RH11240 RH11247 RH11317 RH11390 RH11508 RH11670 RH11723 RH11740 RH12322 RH12457 RH12479 RH13256 RH13496 RH13956 RH14021 RH14060 RH14293 RH14545 RH14548 RH14783 RH16857 RH17045 RH17684 RH18437 RH18468 RH18601 RH18636 RH18942 RH19116 RH19184 RH19231 RH19427 RH19445 RH19626 RH19653 RH19723 RH19852 RH19880 RH20122 RH20430 RH20624 RH20733 RH20748 RH20936 RH20944 RH21270 RH21358 RH21546 RH21670 RH21845 RH22725 RH23713 RH23931 RH24612 RH25327 RH25345 RH26077 RH26154 RH26316 RH26514 RH27460 RH27843 RH28255 RH28468 RH28822 RH29879 RH29936 RH30130 RH30138 RH32687 RH32793 RH33013 RH33341 RH33892 RH34176 RH34250 RH34309 RH34334 RH34743 RH34764 RH34955 RH35873 RH36041 RH36176 RH36388 RH38214 RH38241 RH38783 RH38981 RH39284 RH39664 RH39711 RH40544 RH40559 RH40695 RH41651 RH41817 RH42159 RH42225 RH42445 RH42484 RH43192 RH43213 RH43643 RH43954 RH44041 RH44102 RH44147 RH44309 RH44425 RH44653 RH44711 RH44889 RH45184 RH45232 RH46121 RH46138 RH46226 RH46283 RH46343 RH47858 RH47947 RH49144 RH49591 RH49763 RH49814 RH49826 RH49838 RH50023 RH50139 RH50363 RH50719 RH50916 RH51182 RH51275 RH51350 RH51558 RH51628 RH51733 RH51771 RH51885 RH52057 RH52080 RH52101 RH52420 RH52458 RH53701 RH53866 RH53984 RH54213 RH54250 RH54283 RH54625 RH54643 RH54935 RH56034 RH56921 RH57692 RH57761 RH57805 RH58578 RH58807 RH58996 RH59115 RH59218 RH60153 RH61243 RH61680 RH61932 RH62760 RH62876 RH62914 RH63293 RH63366 RH63573 RH63742 RH63844 RH63926 RH64193 RH64309 RH64846 RH65650 RH65943 RH66226 RH66251 RH66379 RH69434 RH69751 RH69771 RH69989 RH70574 RH70678 RH70849 RH71915 RH71951 RH72065 RH72109 RH72485 RH73072 RH73135 RH73383 RH73658 RH73960 RH74436 RH74454 RH74461 RH74616
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31938
Antibody Information
Other Information
Discoverer
	Postlethwait, Jan. 1979.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	The p47 polypeptide seen previously in ACF (ATP-utilizing chromatin assembly and remodeling factor) fractions (FBrf0095281) has been found to be identical to Yp2 and appears to have been a contaminant in these earlier ACF fractions. (Ito et al., 1999) 20-Hydroxyecdysone, but not juvenile hormone, regulation of yolk protein gene expression can be mapped to cis-acting DNA sequences. It is not clear whether regulation by 20-hydroxyecdysone is direct or indirect. Methoprene up-regulation is only observed when native yolk protein genes are assayed, suggesting that it may operate through influencing stability of the message. (Bownes et al., 1996) Proteins which specifically bind the Yp1/Yp2 ovarian enhancer 1 element have been identified. (Chung et al., 1996) By comparing methylation by Ecol\dam methylase between euchromatic and heterochromatic genes it was determined that the heterochromatic state does not prevent methylase accessibility in vivo. (Wines et al., 1996) srp is expressed in the ovaries of adult flies where it produces an ovary specific protein isoform. The srp protein binds to a 12bp ovarian follicle cell-specific regulatory element located between the divergently transcribed Yp1 and Yp2. The 12bp element activates both in vivo and in vitro transcription of Yp1 and Yp2. (Lossky and Wensink, 1995) Insertion of the gypsy\su(Hw)BR into the Yp1 Yp2 intergenic region does not alter temporal or tissue-specific expression of the Adh or Ecol\lacZ reporter genes but does repress the Yp1 Yp2 fat body enhancer elements. (Scott and Geyer, 1995) The yolk protein genes Yp1 and Yp2 are only expressed in the ovary and fat body of females if they are supplied with proteinaceous food. Several regulatory regions have been shown to independently confer nutritional regulation on the expression of Yp1 and Yp2. (Sondergaard et al., 1995) 343bp of immediately upstream Yp2 sequences are sufficient for expression in the fat bodies. (Abrahamsen et al., 1993) Pattern of osmium zinc iodide staining in the cortical cytoplasm varies in relation to the number of yolk protein structural genes. (Giorgi et al., 1993) CrebA protein binds to the fat body specific enhancers of Dmul\Adh1, Adh, Yp1 and Yp2 and may be an important component of tissue specific regulation. (Abel et al., 1992) Newly synthesised yolk proteins in normal and mutant strains share secretory vesicles with putative vitelline membrane proteins. Translocation of follicle cell yolk protein is not through the membrane along the interfollicular spaces, but directly through plasmalemma facing the oocyte. (Butterworth et al., 1992) Evolutionary conservation of specificity of yolk protein uptake by the oocyte is studied throughout Diptera. (Martinez and Bownes, 1992) Female flies with varying numbers of Yp1, Yp2 and Yp3 genes have been generated. Each yolk protein gene makes an equivalent contribution to the fecundity and fertility of the female, and they do not individually provide unique functions to the embryo. The number of eggs laid by a female depends on the number of genes encoding yolk proteins present in the genome, and the probability of an egg producing an adult depends on the number of yolk protein genes present in the mother. (Bownes et al., 1991) The male and female products of dsx when expressed in E.coli bind specifically to the fat body enhancer (FBE) of Yp1 and Yp2. This demonstrates a direct interaction between the sex determination hierarchy and a target gene. (Burtis et al., 1991) Yp1 and Yp2 are transcribed in the same sub-populations of ovarian follicle cells. This expression is directed by two enhancers: ovarian enhancer 1, located in the 1226bp intergenic region, and ovarian enhancer 2 located within the first exon of Yp2. (Logan and Wensink, 1990) Two cis-acting regions influence the transcription of both Yp1 and Yp2 in the ovaries. One is located in the 1224bp intergenic region and determines the stage and cell type specificity of ovarian transcription. The other is in the first intron of Yp2 and acts across the Yp2 promoter region to stimulate Yp1 transcription in ovaries. (Logan et al., 1989) The site of tyrosine sulfation in the Yp2 protein has been identified. (Baeuerle et al., 1988) Yolk proteins share a certain homologous domains with human low-density lipoproteins and human lipoprotein lipase. (Baker, 1988) The sex-, time- and tissue-specific expression of the Yp1 and Yp2 genes, divergently transcribed and separated by 1225bp, indicates that there are two tissue-specifying elements acting on each gene. One is necessary for expression in fat body and the other for expression in the ovary. (Garabedian et al., 1985) Yp2 has been cloned and sequenced, and compared with Yp1. The intergenic region between Yp1 and Yp2 has also been sequenced. (Hung and Wensink, 1983) Yp2 has been cloned. (Hovemann and Galler, 1982) The exon-intron structure of Yp2 has been determined. (Hung et al., 1982) The three major yolk proteins (encoded by Yp1, Yp2 and Yp3) have been isolated from mature eggs and characterised. (Mintzas and Kambysellis, 1982) Hormonal and genetic regulation of yolk formation has been reviewed. (Postlethwait and Shirk, 1981) Structural gene for the yolk protein YP2 found in recently-emerged female flies. Protein migrates at different rates in SDS-polyacrylamide gels when encoded by the electrophoretic variants Yp2F (fast) and Yp2S (slow), alleles that are female fertile and produce normal amounts of YP2. A mutant Yp2M (=Yp212-1245) is female fertile but lays fewer eggs than normal (Mohler, Postlethwait and Shirk) and does not contain yolk protein in the hemolymph or ovaries.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078547 RefSeq (Proteins) • NP_511102 DDBJ / EMBL / GenBank • AA736194 AAF46547 AAL28590 AI518946 AY061042 CAA25710 L14421 L14422 L14423 X01524 Entrez Gene - A searchable database of RefSeq genes. • 31938 UniProtKB/Swiss-Prot • P02844
Other Crossreferences
	EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters • 07022 07023 InterPro domains - A database of protein families, domains, and functional sites • Lipase (IPR000734) Lipase, N-terminal (IPR013818) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • HL08149
Linkouts
	BioGRID - A database of protein and genetic interactions • 58374 DroID - A comprehensive database of gene and protein interactions. • FBgn0005391 DRSC - Results from RNAi screens. • FBgn0005391 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005391 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2979-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005391 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31938 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31938 modMine - Data generated by the modENCODE project. • FBgn0005391
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG2979 (Camporeale et al., 2007, Nakahara et al., 2005, Fakhouri et al., 2006, Cermelli et al., 2006, Horne et al., 2009, Hughes et al., 2008, Cammarato et al., 2011) fs(1)A59   fs(1)K313 (Butterworth et al., 1990, Perrimon et al., 1986, Perrimon and Gans, 1983, ) fs(1)M35 (Voelker et al., 1989, ) fs(1)m35 (Mohler and Carroll, 1984) VG2 (Persson et al., 1991) VIT2Dm (Horne et al., 2009) YP (Hediger et al., 2004, Carlson and Harshman, 1999, Hutson and Bownes, 2003, Sanchez and Guerrero, 2001, Richard et al., 2001, Sappington and Raikhel, 1998, de Loof et al., 1990, Vanzo et al., 2007, Papassideri et al., 2007, Richard et al., 2005, Trougakos et al., 2001) yp (Kubli, 2003, Schutt and Nothiger, 2000) Yp2 (Baker and Russell, 2009, Kadener et al., 2006, Luo et al., 2011, Sury et al., 2010, Goldman and Arbeitman, 2007, Rees et al., 2011, Kallappagoudar et al., 2010, McDermott and Kliman, 2008, Sun and Cline, 2009, Noor and Kliman, 2003, Sharma and Singh, 2009, McIntyre et al., 2006, Parisi et al., 2004, Fisher et al., 2008) yp2 (Terashima and Bownes, 2004, Kliman et al., 2001, Arnosti, 2002, Fujii and Amrein, 2002, Comeron and Kreitman, 2000, Hey, 1993.10.1, Hey, 1993.10.1, Hey, 1993.10.1, Li and Baker, 1998, McDonald, 1998, Geyer, 1997, Clark, 1997, Duncker et al., 1997, Chung et al., 1996, Bownes et al., 1996, Sondergaard et al., 1995, Bownes, 1994, Brookfield and Sharp, 1994, Giorgi et al., 1993, McKeown and Madigan, 1992, Bownes et al., 1991, Liddell and Bownes, 1991, Lossky and Wensink, 1991, Butterworth et al., 1990, Mitsis and Wensink, 1989, Garabedian et al., 1987, Alvarez et al., 2009) YP2 (Hovemann, 1997.2.17, Chatterjee and Mukherjee, 1996, Butterworth et al., 1991, Maschat et al., 1990, Baeuerle et al., 1988, Bownes and Scott, 1987, Nothiger and Steinmann-Zwicky, 1987, Ota et al., 1981, Flatt et al., 2005, Allen and Spradling, 2008, Slack et al., 2011, Kpebe and Rabinow, 2008) YP-2 (Mintzas and Kambysellis, 1982) YP2 (Granadino et al., 1991) YPII (Hovemann and Galler, 1982)
Name Synonym	vitellogenin (Persson et al., 1991, Sommer et al., 2005) yolk protein (Vieira et al., 1997, Richard et al., 2005) yolk protein 2 (Camporeale et al., 2007, Cermelli et al., 2006, Chintapalli et al., 2012, Tadros et al., 2007, Alvarez et al., 2009, McIntyre et al., 2006) Yolk protein 2 (Fakhouri et al., 2006, Goldman and Arbeitman, 2007, McGraw et al., 2008, Cammarato et al., 2011, Slack et al., 2011)
Secondary FlyBase IDs
	FBgn0000847 FBgn0004046
References ( 210 )
Generate a list of	All references relating to this gene ( 210 )
List References by type	Research paper  ( 148 ) Supplementary material  ( 7 ) Review  ( 24 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 13 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 4 ) Conference report  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 ) Letter  ( 2 ) Book  ( 1 )
Recent research papers ( 7 )
	Chintapalli et al., 2012, PLoS ONE 7(3): e32577 Functional correlates of positional and gender-specific renal asymmetry in Drosophila. [FBrf0218070] Jubeaux et al., 2012, Environ. Sci. Technol. 46(11): 6315--6323 Vitellogenin-like Proteins among Invertebrate Species Diversity: Potential of Proteomic Mass Spectrometry for Biomarker Development. [FBrf0218577] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Rees et al., 2011, Mol. Cell. Proteomics 10(6): M110.002386 In Vivo Analysis of Proteomes and Interactomes Using Parallel Affinity Capture (iPAC) Coupled to Mass Spectrometry. [FBrf0213845] Slack et al., 2011, Aging Cell 10(5): 735--748 dFOXO-independent effects of reduced insulin-like signaling in Drosophila. [FBrf0215229] Yang et al., 2011, G3 (Bethesda) 1(6): 427--436 Partitioning transcript variation in Drosophila: abundance, isoforms, and alleles. [FBrf0217638] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...