Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pch using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\pch in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
The pch complementation group may correspond to tyn; in a complementation test, a pch mutant allele failed to complement the lethality of a tyn allele.
pch2 flies appear normal at eclosion but commence dying immediately; all dead within 12 hr. pch2 progeny recovered about 60% as frequently as expected owing to pre-eclosion mortality in the pupal stage. Approximately 15% of pch2 individuals die before late pupa, 25% in late pupa, and 60% during first 24 hr after eclosion. Adults exhibit uncoordinated leg movement and then lose use of legs. In gynandromorphs, only pch2 tissue shows loss of leg coordination; such mosaics are doomed. pch2 flies killed by light etherization but not by prolonged CO2 narcosis. Fate mapping by method of focusing locates focus of lethal action to thoracic neural ganglia and not to thoracic musculature. Adult pch3 and pch4 flies have higher rates of water loss than wild-type flies, the rapid water loss causing early death in a desiccated environment. In an attempt to compensate for the loss, the mutants drink much more water than wild-type flies. Even dead pch flies lose water more rapidly than their wild-type counterparts, suggesting that a defect in the integument rather than in the digestive or trachea-spiracle systems is the source of the abnormality. pch larvae and pupae are not affected by desiccation. The survival of flies mosaic for pch/+ and pch/0 in a desiccated environment depends on the ratio of wild-type to mutant cuticle. No difference in the chemical composition of the cuticle between pch3 and the wild type detected. The relationship between mutants isolated as parched and doomed remains unclear, considering the reported differences in fate-mapping results (Flanagan, 1977 vs. Kimura et al., 1985).