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Gene Dmel\ey

General Information
Symbol	Dmel\ey	Species	D. melanogaster
Name	eyeless	Annotation symbol	CG1464
Feature type	protein_coding_gene	FlyBase ID	FBgn0005558
Gene Model Status	Current	Stock availability	66 publicly available
Also Known As	Pax6, Pax-6, l(4)33, eye
Genomic Location
Chromosome (arm)	4	Recombination map	4-2.0
Cytogenetic map	102D4-102D5	Sequence location	4:718,315..741,799 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eyeless is referred to in FlyBase by the symbol Dmel\ey (CG1464, FBgn0005558). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity. There is experimental evidence for 14 unique biological process terms, many of which group under: system development; single-organism developmental process; biological regulation; multicellular organismal development; sensory organ development; neuron differentiation; positive regulation of cellular biosynthetic process; positive regulation of nucleobase-containing compound metabolic process; cellular process; localization; locomotory behavior. 66 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult segment; thoracic segment; imaginal precursor; adult; external compound sense organ; peripheral nervous system; appendage segment; embryonic/larval imaginal precursor. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain-like; Paired domain; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1628973_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of ey. Gene sequence location is 4:718315..741799.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	ey: eyeless ey4: eyeless-4 Edith M. Wallace, unpublished. Eye size variably reduced depending on allele (see table); expressivity more variable for some alleles than for others. Tetragonal packing of facets and face-centered tetragonal bristle lattice (eyR) in place of hexagonal array of wild type [Hartman and Hayes, 1971, J. Hered. 62: 41-43 (fig.)]; associated with a failure of the horizontal secondary pigment cell to expand to give rise to the horizontal boundaries between ommatidia [Ready, Hanson, and Benzer, 1976, Dev. Biol. 53: 217-40 (fig.)]. Some ey2 flies show duplications of antennae or antennal segments with or without duplication of aristae; extra maxillary structures also observed (Shatouri, 1963, Caryologia 16: 431-37). Optical disks reduced in size [(ey1) Richards and Farrow, 1922, Proc. Oklahoma Acad. Sci. 2: 41-45; (ey2) Medvedev, 1935, Z. Indukt. Abstamm. Vererbungsl. 70: 55-72 (fig.); 1935, Tr. Inst. Genet. Akad. Nauk SSSR 10: 119-51; Steinberg, 1944, Proc. Nat. Acad. Sci. USA 30: 5-13; (ey4) Chen, 1929, J. Morphol. 47: 135-99]. Degenerating cells abundantly observed in the optic disks of third-instar larvae of ey2 [Fristrom, 1969, Mol. Gen. Genet. 103: 363-79 (fig.); Ransom, 1979, J. Embryol. Exp. Morphol. 53: 225-35]. Expressivity sensitive to genetic background [(ey4) Spofford, 1956, Genetics 41: 938-59; (ey1, ey2, ey4, eyK) Hunt and Burnet, 1969, Genet. Res. 13: 251-65]. Phenotype also responds to developmental temperature, larval density, and composition of medium. Eye size reported to increase with increased temperature in e1 (Baron, 1935, J. Exp. Zool. 70: 461-90) and eyK (Sang and Burnet, 1963, Genetics 48: 1683-99) but to decrease in eyW (Meyer, 1959, DIS 33: 97). Phenotype less extreme in flies raised under crowded conditions at 18 but not 25 (Sang and Burnet, 1963; see also Chester, 1971, DIS 46: 62-63). Eye size of four alleles increased by cholesterol deprivation and decreased by dietary deficiencies in thiamine or RNA (Hunt and Burnet, 1969). Larval feeding of lactamide to ey2 causes decreased eye size, which is of opposite sign from its effect on B (Grant and Rapport, 1980, DIS 55: 53); no such effect of lactamide on eyK observed by Sang and Burnet (1963). ey2 flies exhibit normal visual orientation in Y maze (Bulthoff, 1982, DIS 58: 31). ey2, ey4, and eyK in combination with eyg (3-35.5) results in almost complete curtailment of eye development and synthetic lethality, with the major lethal crisis at the end of the pupal stage and a minor lethal phase at pupation; rare surviving adults have brain in anterior thorax [Hunt, 1970, Genet. Res. 15: 29-34 (fig.)]. eyD: eyeless-Dominant eyD: eyeless-Dominant Left: head. Right: first pair of legs. From Patterson and Muller, 1930, Genetics 15: 495-577. Eyes of heterozygotes small, outline irregular, displaced toward top and rear. Head large, often with duplicated antennae or ocelli. Basitarsus broadened distally and incompletely separated from second tarsal segment owing to interruptions of the intersegmental membrane. Polarity of bract-bristle arrangement locally reversed in regions of membrane gaps [Poodry and Schneiderman, 1976, Wilhelm Roux's Arch. Dev. Biol. 180: 175-88 (fig.)]. 27-48 sex-comb teeth disposed in more-or-less parallel longitudinal rows in males; number of transverse-bristle rows increased in females (Stern and Tokunaga, 1967, Proc. Nat. Acad. Sci. USA 57: 658-64). Extra leg joints tend to form as mirror-image duplications proximal to the normal joint between the first and second tarsal joints (Held, Duarte, and Derakhshanian, 1986, Wilhelm Roux's Arch. Dev. Biol. 195: 145-57). Clones of ey+ tissue in eyD/+ background exhibit eyD/+ phenotype (Stern and Tokunaga, 1967), but both ey+ leg disks transplanted into eyD hosts and the reciprocal transplant develop autonomously (Tokunaga, 1970, Dev. Biol. 18: 401-13). fj eyD flies have but three tarsal joints (Postlethwaite and Schneiderman, 1975, Annu. Rev. Genet. 7: 381-433). Fully dominant in triplo-4 flies (Sturtevant, 1936, Genetics 21: 448). Eye size of B; eyD/+ males larger than of B alone. Produces extreme phenotype in combination with D. D/+; eyD/+ almost completely lethal (Sobels, Kruijt, and Spronk, 1951, DIS 25: 128). Homozygous lethal; two lethal crises, one during first or second larval instar and the other just prior to or during pupal stage. Cell degeneration observed in optic disks of homozygous second-instar larval (Ransom, 1979, J. Embryol. Exp. Morphol. 53: 225-35). Larvae which are unable to pupate rescuable by injection of α-ecdysone (Arking, 1969, J. Exp. Zool. 171: 285-96). Homozygotes reaching pupal stage lack adult derivatives of eye-antennal disks; adult derivatives are formed by eyD/eyD eye-antennal disks transplanted into wildtype hosts; brain present but number of cortical cells severely reduced (Arking, Putnam, and Schubiger, 1975, J. Expt. Zool. 193: 301-12). RK2.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Transgenic Constructs P{ey-FLP.U}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102D4-102D5
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	4-2.0 (Sturtevant, 1951)
Left of (cM)
Right of (cM)
Notes	Mapped by recombination in diplo-4 triploids. (Sturtevant, 1951)
Gene Model & Products
Please see the GBrowse view of Dmel\ey for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ey-RA FBtr0089236  NM_079889   3282   838 ey-RB FBtr0089235  NM_166789   2854   624 ey-RC FBtr0100395  NM_001014694   2902   857 ey-RD FBtr0100396  NM_001014693   3462   898
Additional Transcript Data & Comments
Reported size (kB)	2.8 (longest cDNA) (Quiring et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ey-PA   FBpp0088300   87.6   838   7.79     NP_524628   AAF59318 ey-PB   FBpp0088299   65.1   624   7.01     NP_726607   AAN06513 ey-PC   FBpp0099809   89.4   857   7.56     NP_001014694   AAX52513 ey-PD   FBpp0099810   93.8   898   7.38     NP_001014693   AAX52512
Additional Polypeptide Data & Comments
Reported size (kDa)	857, 838 (aa); 82.5 (kD predicted) (Quiring et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Paired domain (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014135 AAF59318   AE014135 AAN06513   AE014135 AAX52512   AE014135 AAX52513   AC010576   AC099309   AF089733 AAD54001   AF433696 AAM17959   AF433697 AAM17960   AF433698 AAM17961   AF433699 AAM17962   AF433700 AAM17963   AF433701 AAM17964   AF433702 AAM17965   AF433703 AAM17966   AF433704 AAM17967   AF433705 AAM17968   AI062092   AJ131630 CAA10461   BT011390   BT025949   CO191074   CO288666   CO300631   CO302888   CO305605   CO307645   CO345507   CZ479948   EC078400   EC087177   EC196236   EC214913   EC217202   EC223150   EC230014   EC237895   EL874913   EL874914   EL875029   EL875142   X79492 CAA56037   X79493 CAA56038
UniProtKB/Swiss-Prot	O18381
UniProtKB/TrEMBL	Q59DQ2 Q59DQ1 O96791 Q9U8F7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References enhancer FBsf0000161154 4:730,631..730,841 comment=eye-specific enhancer; 212bp fragment drives expression of a reporter gene in the eye primordia from stage 15 embryos through to third instar larvae. evidence=experimental (Hauck et al., 1999) regulatory region FBsf0000435091 4:722,315..724,597 evidence=Reporter construct (in vivo) (Adachi et al., 2003, Halfon, 2012.6.19) regulatory region FBsf0000435213 4:730,631..730,841 evidence=Reporter construct (in vivo) (Hauck et al., 1999, Halfon, 2012.6.19) regulatory region FBsf0000435312 4:728,055..730,834 evidence=Reporter construct (in vivo) (Hauck et al., 1999, Halfon, 2012.6.19) regulatory region FBsf0000435443 4:721,814..722,814 evidence=Reporter construct (in vivo) (Adachi et al., 2003, Halfon, 2012.6.19) regulatory region FBsf0000435815 4:724,597..725,290 evidence=Reporter construct (in vivo) (Adachi et al., 2003, Halfon, 2012.6.19) regulatory region FBsf0000436239 4:730,670..730,868 evidence=Reporter construct (in vivo) (Hauck et al., 1999, Halfon, 2012.6.19) regulatory region FBsf0000436279 4:730,550..730,829 evidence=Reporter construct (in vivo) (Xu et al., 1999, Halfon, 2012.6.19) regulatory region FBsf0000436425 4:730,634..731,668 evidence=Reporter construct (in vivo) (Hauck et al., 1999, Halfon, 2012.6.19) regulatory region FBsf0000436765 4:720,531..725,290 evidence=Reporter construct (in vivo) (Adachi et al., 2003, Halfon, 2012.6.19) regulatory region FBsf0000436818 4:720,531..722,315 evidence=Reporter construct (in vivo) (Adachi et al., 2003, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   adult mushroom body   (Kobayashi et al., 2006) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Quiring et al., 1994) eye-antennal disc primordium   (Quiring et al., 1994) embryonic stage 9 -- 10   procephalic neurogenic region & embryonic ocular segment | restricted   (Urbach and Technau, 2003) stage 2 neuroblast | segmentally repeated   (Noveen et al., 2000) central brain primordium   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 9 -- 11   protocerebral neuroblast | subset   (Urbach and Technau, 2003) tritocerebral neuroblast | subset   (Urbach and Technau, 2003) procephalic neurogenic region & embryonic intercalary segment | restricted   (Urbach and Technau, 2003) deuterocerebral neuroblast | subset   (Urbach and Technau, 2003) procephalic neurogenic region & embryonic antennal segment | restricted   (Urbach and Technau, 2003) embryonic stage 9 -- 17   embryonic ventral neuromere | segmentally repeated   (Kammermeier et al., 2001) embryonic stage 9 -- first instar larval stage   mushroom body neuroblast   (Noveen et al., 2000) embryonic stage 10 -- 16   ventral nerve cord | segmentally repeated   (Czerny et al., 1999) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) mushroom body primordium   (Fisher et al., 2012) organism | segmentally repeated   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Czerny et al., 1999, Fisher et al., 2012) adult eye primordium   (Fisher et al., 2012) mushroom body primordium   (Fisher et al., 2012) Comment:reported as embryonic central brain mushroom body organism | segmentally repeated   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 14 -- 17   embryonic brain   (Kammermeier et al., 2001) embryonic stage 15   embryonic brain   (Hauck et al., 1999) ventral nerve cord | segmentally repeated   (Hauck et al., 1999) eye-antennal disc primordium   (Hauck et al., 1999) third instar larval stage   eye-antennal disc | anterior   (Quiring et al., 1994) Kenyon cell   (Noveen et al., 2000) wandering third instar larval stage   eye disc anterior to the morphogenetic furrow   (Czerny et al., 1999) adult stage   adult mushroom body   (Kobayashi et al., 2006) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Kronhamn et al., 2002) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12   Bolwig organ   (Sheng et al., 1997) embryonic stage 16 -- 17   Bolwig organ   (Sheng et al., 1997) pupal stage     (Sheng et al., 1997) adult stage   adult head   (Sheng et al., 1997)
Additional Descriptive Data
	ey is expressed in a cluster of approximately 10-12 cells beginning at stage 9 of embryogenesis, which correspond to the mushroom body neuroblasts. As the mushroom body neuroblasts delaminate they maintain ey expression, whereas expression diminishes in ectodermal cells that stay on the surface. ey is also expressed in a small group of neuroblasts in the deutocerebrum and tritocerebrum and in segmentally reiterated groups of three SII neuroblasts in the ventral nerve cord. Levels of expression are noted to decline by embryogenesis stage 13. (Noveen et al., 2000) Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1, d2; deuterocerebrum - d4, v6, v7; protocerebrum - ad7, cd2, cd14, cv6, cv7, cv9, pd12, pd18, pd20, pv2 (Urbach and Technau, 2003) Developmental northern blots show that transcript can be detected throughout development. (Kronhamn et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   procephalic neurogenic region & embryonic ocular segment | restricted   (Urbach and Technau, 2003) embryonic stage 9 -- 11   procephalic neurogenic region & embryonic antennal segment | restricted   (Urbach and Technau, 2003) tritocerebral neuroblast | subset   (Urbach and Technau, 2003) procephalic neurogenic region & embryonic intercalary segment | restricted   (Urbach and Technau, 2003) protocerebral neuroblast | subset   (Urbach and Technau, 2003) deuterocerebral neuroblast | subset   (Urbach and Technau, 2003) embryonic stage 11 -- 17   embryonic ventral neuromere | segmentally repeated   (Kammermeier et al., 2001) deuterocerebral neuromere | restricted   (Kammermeier et al., 2001) protocerebral neuromere | restricted   (Kammermeier et al., 2001) tritocerebral neuromere | restricted   (Kammermeier et al., 2001) adult stage   adult mushroom body   (Siegrist et al., 2010)
Additional Descriptive Data
	Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1, d2; deuterocerebrum - d4, v6, v7; protocerebrum - ad7, cd2, cd14, cv6, cv7, cv9, pd12, pd18, pd20, pv2 (Urbach and Technau, 2003)
Marker for
	mushroom body
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{ey-GAL4.S} Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   morphogenetic furrow | anterior to   (Lai et al., 2000) morphogenetic furrow | anterior to   (Robertson et al., 2002, Lai and Rubin, 2001)   eye   (Lyko et al., 1999) Reporter: P{GAL4-ey.H} Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   eye disc   (Hazelett et al., 1998)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    136.7 Larval Midgut    2.3 Larval Hindgut    1.8 Larval Malpighian Tubules    1.2 Larval Fat Body    7.3 Larval Salivary Gland    2.5 Larval Trachea    2.6 Larval Carcass    1.475 Adult Head    49.9 Adult Eye    86.975 Adult Brain    177.4 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop    1.8 Adult Midgut    4 Adult Hindgut    3 Adult Malpighian Tubules    2 Adult Fat Body    2.4 Adult Salivary Gland    4.9 Adult Heart    0.775 Adult VirginFemale Spermatheca    0.8 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    2.6 Adult Testis    3.4 Adult Male Accessory Gland    2.7 Adult Carcass    2.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    86.975   NA  Brain    177.4   136.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    59.7   NA  Crop    1.8   2.3  Midgut    4   1.8  Hindgut    3   1.2  Malpighian Tubules    2   7.3  Fat Body    2.4   2.5  Salivary Gland    4.9   NA  Heart    0.775   2.6  Trachea    NA   NA  VirginFemale Spermatheca    0.8   NA  InseminatedFemale Spermatheca    1.5   NA  Ovary    2.6   NA  Testis    3.4   NA  Male Accessory Gland    2.7   1.475  Carcass    2.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    9 central nervous system, pupae P8    7 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    7 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    8 head, mated 4-day male    9 head, mated 20-day male    10 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    1 embryo 04-06hr    3 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    4 embryo 12-14hr    4 embryo 14-16hr    3 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    4 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    2 adult male 01day    2 adult male 05day    2 adult male 30day    3 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    2 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    2 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_06
External Data & Images
Linkouts	BDGP expression data • GH01157 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005558 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1464-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(4)J2) eyJD lethal | embryonic stage, with Scer\GAL4hs.PB eyScer\UAS.cHa lethal | heat sensitive eyhs.PH lethal | larval stage, with Scer\GAL4ey-OK107 eyScer\UAS.cHa lethal | partially (with Df(4)J2) eyD1Da lethal | partially (with eyJ5.71) eyJD lethal | partially (with eyJD) eyJ5.71 lethal | partially | recessive ey2 eyD1Da eyJ5.71 eyJD eyR lethal | pharate adult stage eydsRNA.cKa lethal | pupal stage eyD eyJ5.71 lethal | pupal stage | recessive eyl1 eyl2 eyl3 eyl4 lethal | recessive eyD viable ey46 ey107.6B.1 eyOK107-6 eyW viable, with Scer\GAL4pnr-MD237 eyGD1440 viable (with ey2) eyD1Da eyJD viable (with eyD1Da) ey2 eyJ5.71 eyR viable (with eyJ5.71) eyD1Da viable (with eyJD) ey2 eyR viable (with eyR) eyD1Da eyJD Sterility Allele fertile eyW Other Phenotypes Allele decreased cell size (with eyD1Da) eyJD decreased cell size (with eyJD) eyD1Da increased cell death ey2 increased cell death | larval stage eyD locomotor behavior defective eyD1Da eyJD neuroanatomy defective eyD1Da eyJD eyOK107 neuroanatomy defective, with Scer\GAL4ey-OK107 eyScer\UAS.cHa neuroanatomy defective (with Df(4)J2) eyD1Da eyJD neuroanatomy defective (with eyD1Da) eyJ5.71 neuroanatomy defective (with eyJ5.71) eyD1Da eyJD neuroanatomy defective (with eyJD) eyJ5.71 small body (with eyD1Da) eyJD small body (with eyJD) eyD1Da visible ey1 ey2 ey4 ey34 ey36 eyAD eyD1Da eyD39 eyD eyJ5.71 eyJD eyK eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 eyR eytu visible, with Scer\GAL430A eyScer\UAS.cHa visible, with Scer\GAL4Bx-MS1096 eyScer\UAS.cHa visible, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa eyΔPD.Scer\UAS visible, with Scer\GAL4ey.PH ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en eyScer\UAS.cHa visible, with Scer\GAL4MS941 eyScer\UAS.cHa visible, with Scer\GAL4p339 eyScer\UAS.cHa visible, with Scer\GAL4unspecified eyScer\UAS.cHa visible, with Scer\GAL4upd-E132 eyScer\UAS.cHa visible (with Df(4)J2) eyD1Da eyJD visible (with ey2) eyOK107-16 visible (with eyD1Da) eyJ5.71 eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 eyR visible (with eyEH) eyOK107-16 visible (with eyJ5.71) eyD1Da eyJD visible (with eyJD) eyJ5.71 eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 eyR visible (with eyOK107-4) eyD1Da eyJD eyOK107-6 eyOK107-10 eyOK107-16 visible (with eyOK107-6) eyD1Da eyJD eyOK107-4 eyOK107-10 eyOK107-16 visible (with eyOK107-10) eyD1Da eyJD eyOK107-4 eyOK107-6 eyOK107-16 visible (with eyOK107-16) ey2 eyD1Da eyEH eyJD eyOK107-4 eyOK107-6 eyOK107-10 visible (with eyR) eyD1Da eyJD visible | adult stage, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa visible | heat sensitive ey1 visible | recessive ey2 ey46 eyW Phenotype manifest in Allele adult brain eyD1Da eyJD adult central complex eyD1Da eyJD adult central complex (with Df(4)J2) eyD1Da eyJD adult central complex (with eyD1Da) eyJ5.71 eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 adult central complex (with eyEH) eyOK107-16 adult central complex (with eyJ5.71) eyD1Da eyJD adult central complex (with eyJD) eyJ5.71 eyOK107-4 eyOK107-6 eyOK107-16 adult central complex (with eyOK107-4) eyD1Da eyJD eyOK107-6 eyOK107-10 eyOK107-16 adult central complex (with eyOK107-6) eyD1Da eyJD eyOK107-4 eyOK107-10 eyOK107-16 adult central complex (with eyOK107-10) eyD1Da eyOK107-4 eyOK107-6 eyOK107-16 adult central complex (with eyOK107-16) eyD1Da eyEH eyJD eyOK107-4 eyOK107-6 eyOK107-10 adult head eyD eydsRNA.cKa adult mushroom body eyD1Da eyJD eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 adult mushroom body (with Df(4)J2) eyD1Da eyJD adult mushroom body (with eyD1Da) eyJ5.71 eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 adult mushroom body (with eyEH) eyOK107-16 adult mushroom body (with eyJ5.71) eyD1Da eyJD adult mushroom body (with eyJD) eyJ5.71 eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 adult mushroom body (with eyOK107-4) eyD1Da eyJD eyOK107-6 eyOK107-10 eyOK107-16 adult mushroom body (with eyOK107-6) eyD1Da eyJD eyOK107-4 eyOK107-10 eyOK107-16 adult mushroom body (with eyOK107-10) eyD1Da eyJD eyOK107-4 eyOK107-6 eyOK107-16 adult mushroom body (with eyOK107-16) eyD1Da eyEH eyJD eyOK107-4 eyOK107-6 eyOK107-10 adult pars intercerebralis (with eyD1Da) eyJD adult pars intercerebralis (with eyJD) eyD1Da antenna eyJD eyK eytu antenna, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa antenna, with Scer\GAL4upd-E132 eyScer\UAS.cHa antenna & eye | ectopic, with Scer\GAL4upd-E132 eyScer\UAS.cHa antenna | ectopic, with Scer\GAL4ey.PH, ey2 eyΔHD.Scer\UAS antenna | ectopic, with Scer\GAL4ey.PH, eyΔHD.Scer\UAS ey2 antenna | proximal, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa antennal disc & eye | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa anterior vertical bristle ey46 arista eyJD circumesophageal tract, with Scer\GAL4sca-537.4 eyScer\UAS.cHa commissure, with Scer\GAL4sca-537.4 eyScer\UAS.cHa cortex of medulla eyD1Da ellipsoid body eyD1Da eyJD eyunspecified ellipsoid body, with Scer\GAL4ey-OK107 ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en embryonic/larval hemolymph | late third instar larval stage eyJD embryonic/larval optic lobe | somatic clone, with Scer\GAL4ey-OK107 ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en embryonic brain, with Scer\GAL4sca-537.4 eyScer\UAS.cHa embryonic central brain neuron, with Scer\GAL4sca-537.4 eyScer\UAS.cHa eye ey1 ey2 ey34 ey36 ey4 ey46 eyAD eyD eyD1Da eyD39 eyJ5.71 eyJD eyK eyR eyW eytu eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 eye, with Scer\GAL4dpp.blk1, ey2 eyΔPD.Scer\UAS eye, with Scer\GAL4dpp.blk1, eyΔPD.Scer\UAS ey2 eye, with Scer\GAL4ey.PH ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en eyScer\UAS.cHa eye, with Scer\GAL4ey.PH, ey2 eyΔHD.Scer\UAS eye, with Scer\GAL4ey.PH, eyΔHD.Scer\UAS ey2 eye, with Scer\GAL4unspecified eyScer\UAS.cHa eye (with Df(4)BA) eyJD eye (with Df(4)J2) eyD1Da eyJD eye (with ey2) eyD eyOK107-16 eye (with eyD1Da) eyJ5.71 eyR eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 eye (with eyD) ey2 eyR eye (with eyEH) eyOK107-16 eye (with eyJ5.71) eyD1Da eyJD eye (with eyJD) eyJ5.71 eyR eyOK107-4 eyOK107-6 eyOK107-10 eyOK107-16 eye (with eyOK107-4) eyD1Da eyJD eyOK107-6 eyOK107-10 eyOK107-16 eye (with eyOK107-6) eyD1Da eyJD eyOK107-4 eyOK107-10 eyOK107-16 eye (with eyOK107-10) eyD1Da eyJD eyOK107-4 eyOK107-6 eyOK107-16 eye (with eyOK107-16) ey2 eyD1Da eyEH eyJD eyOK107-4 eyOK107-6 eyOK107-10 eye (with eyR) eyD eyD1Da eyJD eye | ectopic, with Scer\GAL4Act5C.PI eyScer\UAS.cHa eye | ectopic, with Scer\GAL4Bx-MS1096 eyScer\UAS.cHa eye | ectopic, with Scer\GAL4dpp.blk1 eyΔHD.Scer\UAS eyΔPD.Scer\UAS eyScer\UAS.T:Zzzz\FLAG,T:SV40\nls2 eyScer\UAS.cHa eye | ectopic, with Scer\GAL4dpp.blk1, ey2 eyΔHD.Scer\UAS eye | ectopic, with Scer\GAL4dpp.blk1, eyJ5.71 eyΔHD.Scer\UAS eye | ectopic, with Scer\GAL4dpp.blk1, eyΔHD.Scer\UAS ey2 eyJ5.71 eye | ectopic, with Scer\GAL4MS941 eyScer\UAS.cHa eye | ectopic, with Scer\GAL4upd-E132 eyScer\UAS.cHa eye | ectopic | heat sensitive eyhs.PH eye | ectopic | somatic clone, with Scer\GAL430A eyScer\UAS.cHa eye | ectopic | somatic clone, with Scer\GAL4Act5C.PI eyScer\UAS.cHa eye | ectopic | somatic clone, with Scer\GAL4ap-md544 eyScer\UAS.cHa eye | ectopic | somatic clone, with Scer\GAL4bi-omb-Gal4 eyScer\UAS.cHa eye | heat sensitive ey1 eye | pharate adult stage, with Scer\GAL4dpp.blk1 eyΔPAI.Scer\UAS eye-antennal disc ey2 ey4 eyD eyR eye disc ey1 ey2 eye photoreceptor cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa eye photoreceptor cell & ventral thoracic disc | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa eye photoreceptor cell | ectopic & antennal disc, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa fan-shaped body eyD1Da eyJD gena ey46 glial cell, with Scer\GAL4sca-537.4 eyScer\UAS.cHa haltere, with Scer\GAL4upd-E132 eyScer\UAS.cHa haltere & eye | ectopic, with Scer\GAL4upd-E132 eyScer\UAS.cHa haltere & ommatidium | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa haltere | proximal, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa haltere disc, with Scer\GAL430A eyScer\UAS.cHa head eyD eytu head bristle | ectopic, with Scer\GAL4Act5C.PI eyScer\UAS.cHa intersegmental nerve, with Scer\GAL4sca-537.4 eyScer\UAS.cHa Kenyon cell eyR Kenyon cell, with Scer\GAL4238Y eyScer\UAS.cHa lamina eyD1Da lamina anlage glial cell ey1 leg, with Scer\GAL4dpp.blk1 eyΔPD.Scer\UAS eyScer\UAS.cHa leg, with Scer\GAL4upd-E132 eyScer\UAS.cHa leg & eye | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa leg & eye | ectopic, with Scer\GAL4upd-E132 eyScer\UAS.cHa lobe system of mushroom body eyD1Da eyJD eyOK107 lobula eyD1Da lobula plate eyD1Da longitudinal connective, with Scer\GAL4sca-537.4 eyScer\UAS.cHa maxillary palpus eyJD medial branch of mushroom body ey2 eyR median bundle (with eyD1Da) eyJD median bundle (with eyJD) eyD1Da medulla eyD1Da medulla | somatic clone, with Scer\GAL4ey-OK107 ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en mushroom body eyD1Da eyJD eyR eyunspecified mushroom body, with Scer\GAL4ey-OK107 eyScer\UAS.cHa mushroom body & neuron eyD1Da eyJD mushroom body calyx eyD1Da eyJD mushroom body vertical lobe, with Scer\GAL4238Y eyScer\UAS.cHa mushroom body vertical lobe, with Scer\GAL4ey-OK107 eyScer\UAS.cHa mushroom body vertical lobe, with Scer\GAL4hs.PB eyScer\UAS.cHa neurite (with eyD1Da) eyJD neurite (with eyJD) eyD1Da neuron | ectopic, with Scer\GAL430A eyScer\UAS.cHa neuropil & mushroom body & pupa eyunspecified ommatidium ey2 ommatidium, with Scer\GAL4ey.PH eyScer\UAS.cHa ommatidium | ectopic, with Scer\GAL4ap-md544 eyScer\UAS.cHa ommatidium | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa optic lobe ey1 ey2 eyD1Da eyJD optic lobe | pupal stage | somatic clone, with Scer\GAL4ey-OK107 ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en photoreceptor | ectopic | somatic clone, with Scer\GAL4Act5C.PI eyScer\UAS.cHa photoreceptor | ectopic | third instar larval stage, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa photoreceptor cell ey1 posterior vertical bristle ey46 proboscis & ommatidium | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa protocerebral bridge eyD1Da retina ey2 retina | ectopic, with Scer\GAL430A eyScer\UAS.cHa segmental nerve, with Scer\GAL4sca-537.4 eyScer\UAS.cHa serpentine layer eyD1Da subretinal glial cell ey1 third segment of antenna eyJD tibia, with Scer\GAL4Act5C.PI eyScer\UAS.cHa tritocerebral commissure, with Scer\GAL4sca-537.4 eyScer\UAS.cHa ventral nerve cord, with Scer\GAL4sca-537.4 eyScer\UAS.cHa ventral thoracic disc, with Scer\GAL4hs.2sev eyScer\UAS.cHa ventral thoracic disc & eye | ectopic, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa vertical branch of mushroom body, with Scer\GAL4238Y eyScer\UAS.cHa vertical branch of mushroom body, with Scer\GAL4hs.PB eyScer\UAS.cHa vibrissae ey46 wing, with Scer\GAL430A eyScer\UAS.cHa wing, with Scer\GAL4Act5C.PI eyScer\UAS.cHa wing, with Scer\GAL4Bx-MS1096 eyScer\UAS.cHa wing, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa wing, with Scer\GAL4MS941 eyScer\UAS.cHa wing, with Scer\GAL4p339 eyScer\UAS.cHa wing, with Scer\GAL4upd-E132 eyScer\UAS.cHa wing (with eyD1Da) eyJD wing (with eyJD) eyD1Da wing & eye | ectopic, with Scer\GAL4MS941 eyScer\UAS.cHa wing & eye | ectopic, with Scer\GAL4upd-E132 eyScer\UAS.cHa wing | proximal, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa wing disc, with Scer\GAL430A eyScer\UAS.cHa wing disc, with Scer\GAL4ap-md544 eyScer\UAS.cHa wing disc, with Scer\GAL4dpp.blk1 eyΔPAI.Scer\UAS wing disc, with Scer\GAL4hs.2sev eyScer\UAS.cHa wing disc | anterior/posterior compartment boundary | somatic clone, with Scer\GAL430A eyScer\UAS.cHa wing disc | anterior/posterior compartment boundary | somatic clone, with Scer\GAL4Act5C.PI eyScer\UAS.cHa wing disc | anterior/posterior compartment boundary | somatic clone, with Scer\GAL4ap-md544 eyScer\UAS.cHa wing disc | anterior/posterior compartment boundary | somatic clone, with Scer\GAL4bi-omb-Gal4 eyScer\UAS.cHa wing disc | posterior | somatic clone, with Scer\GAL430A eyScer\UAS.cHa wing disc | posterior | somatic clone, with Scer\GAL4Act5C.PI eyScer\UAS.cHa wing disc | posterior | somatic clone, with Scer\GAL4ap-md544 eyScer\UAS.cHa wing disc | posterior | somatic clone, with Scer\GAL4bi-omb-Gal4 eyScer\UAS.cHa wing hinge, with Scer\GAL4Bx-MS1096 eyScer\UAS.cHa wing hinge, with Scer\GAL4dpp.blk1 eyScer\UAS.cHa
Classical Alleles ( 40 )
For All Classical Alleles Show
Allele of ey Class Mutagen Stocks Known lesion eyD X ray 27 Yes eyR hypomorphic allele - genetic evidence spontaneous 13 Yes ey2 amorphic allele - genetic evidence, hypomorphic allele - genetic evidence spontaneous 5 Yes ey1 spontaneous 2 -- ey4 spontaneous 2 -- eyOK107-16 ethyl methanesulfonate 2 Yes eyOK107 2 Yes eyB320 1 -- eyBG00784 P-element activity 1 -- eye02123 piggyBac transposase 1 -- eye04282 1 -- eye04624 1 -- eyJ5.71 loss of function allele ethyl methanesulfonate 1 Yes eyMB00784 1 -- ey+ 0 -- ey107.6B.1 0 -- ey11 ethyl methanesulfonate 0 Yes ey34 cold-treatment 0 -- ey36 spontaneous 0 -- ey46 X ray 0 -- ey6115 spontaneous 0 Yes ey67 spontaneous 0 -- eyAD spontaneous 0 -- eyC7.20 loss of function allele ethyl methanesulfonate 0 -- eyCB-0242-3 0 -- eyD1Da diepoxybutane 0 Yes eyD39 X ray 0 -- eyEH diepoxybutane 0 Yes eyJD antimorphic allele - genetic evidence ethyl methanesulfonate 0 Yes eyK spontaneous 0 -- eyl1 ethyl methanesulfonate 0 -- eyl2 ethyl methanesulfonate 0 -- eyl3 ethyl methanesulfonate 0 -- eyl4 spontaneous 0 -- eyOK107-10 ethyl methanesulfonate 0 Yes eyOK107-4 ethyl methanesulfonate 0 Yes eyOK107-6 ethyl methanesulfonate 0 Yes eytu spontaneous 0 -- eyunspecified 0 -- eyW spontaneous 0 --
Alleles Carried on Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ey Class Mutagen Stocks Known lesion eyScer\UAS.cHa in vitro construct - regulatory fusion 2 Yes ey1-545.Scer\UAS.T:Hsap\MYC,T:Rep-en in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes eyGD1440 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eyHMS00489 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eyJF02501 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eyKK107100 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eyT:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes ey+t.p6 in vitro construct - genomic fragment 0 Yes eyAct5C.PB in vitro construct - regulatory fusion 0 Yes eydsRNA.A in vitro construct - RNAi 0 Yes eydsRNA.B in vitro construct - RNAi 0 Yes eydsRNA.cKa in vitro construct - RNAi 0 Yes eyhs.PH in vitro construct - regulatory fusion 0 Yes eymEYE-ey in vitro construct - regulatory fusion in vitro construct - minigene 0 Yes eyScer\UAS.N.T:Avic\GFP-VC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eyScer\UAS.N.T:Avic\GFP-VN in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eyScer\UAS.T:Zzzz\FLAG,T:SV40\nls2 in vitro construct - regulatory fusion 0 Yes eyt.p14 in vitro construct - genomic fragment 0 Yes eyΔCT.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes eyΔCTD.Scer\UAS in vitro construct - regulatory fusion 0 Yes eyΔHD.Scer\UAS in vitro construct - regulatory fusion 0 Yes eyΔPAI.Scer\UAS in vitro construct - deletion 0 Yes eyΔPD+ΔHD.Scer\UAS in vitro construct - regulatory fusion 0 Yes eyΔPD.Scer\UAS in vitro construct - regulatory fusion 0 Yes eyΔPDPMHD.Scer\UAS in vitro construct - amino acid replacement 0 Yes eyΔRED.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Duplicated in	C(1;Y;4)d7 (Ahmad and Golic, 1998) Dp(1;4)193   Dp(2;4)eyD (Hochman et al., 1964) Dp(4;3)eyD (Tokunaga, 1969)
Not duplicated in	Dp(1;Y)su(f)+ (Gethmann, 1967) Ts(1Lt;4Lt)wmJ   Ts(2Lt;4Lt)b (Morgan, 1947)
Not disrupted in	Df(4)G (Kronhamn et al., 2002, Hochman et al., 1964) Df(4)M101-4 (Hochman et al., 1964) Df(4)spa30 (Kronhamn et al., 2002) Df(4)spa47 (Kronhamn et al., 2002) Df(4)spa66 (Kronhamn et al., 2002) Df(4)spam18 (Kronhamn et al., 2002) Df(4)spam100 (Kronhamn et al., 2002) T(1;4)scH (Sousa-Neves, 1999.11.10, Sousa-Neves, 2000)
Disrupted in	Df(4)BA (Kronhamn et al., 2002, Benassayag et al., 2003) Df(4)ED6382 (Ryder and Roote, 2004.11.10) Df(4)ED6384 (Ryder and Roote, 2004.11.10) Df(4)J2 (Callaerts et al., 2001) Df(4)O2 (Kammermeier et al., 2001)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1440} NA P{KK107100} NA P{TRiP.HMS00489} NA P{TRiP.JF02501} NA P{UAS-ey.FLAG.nls} NA P{UAS-ey.H} NA P{UAS-ey.ΔCT} NA P{UAS-ey.ΔCTD} NA P{UAS-ey.ΔHD} NA P{UAS-ey.ΔPAI} NA P{UAS-ey.ΔPD} NA P{UAS-ey.ΔPD+ΔHD} NA P{UAS-ey.ΔPDPMHD} NA P{UAS-VC-ey} NA P{UAS-VN-ey} NA reporter construct P{ey3.5-lacZ} No P{ey.12E-lacZ} No P{ey.12ER-lacZ} No P{ey.12-lacZ} No P{ey.Dm05-lacZ} No P{ey.Dm06-lacZ} No P{ey.Dm07-lacZ} No P{ey.UE0.8-lacZ} No P{ey.UE0.9-lacZ} No P{ey.UE2.0-lacZ} No P{ey.UE2.3-lacZ} No P{EYE-lacZ.H} No P{ey-lacZ.0.5} No P{ey-lacZ.0.28} No P{ey-lacZ.1.2} No P{ey-lacZ.3D27} No P{ey-lacZ.5D12} No P{ey-lacZ.B2} No P{ey-lacZ.B4M} No P{ey-lacZ.B18} No P{ey-lacZ.Bh300} No P{ey-lacZ.Bm300} No P{ey-lacZ.C} No P{ey-lacZ.D02} No P{ey-lacZ.E3.6R} No P{ey-lacZ.E36} No P{ey-lacZ.mut} No P{lacZ.ey.1.6.B4M} No P{lacZ.ey.1.6.B4M-so} No P{lacZey3.6} No P{lacZey.1.6} No GAL4 construct P{ey-GAL4.S} No P{ey-GAL4.U} No P{ey-tTA} No P{GAL4-ey.B} No P{GAL4-ey.H} No heat-shock construct P{hs-ey} NA characterization construct P{ey1x-GAL4.Exel} NA P{ey3.5-GAL4.Exel} NA P{Ey(FRT.e)F7Y(loxP.7F)W.R} NA P{Ey(FRT.e)F7Y(-loxP)W.R} NA P{Ey(-FRT)F7Y(loxP.7F)W.R} NA P{Ey(-FRT)F7Y(-loxP)W.R} NA P{EYE-ey.H} NA P{ey-FLP.3.5} NA P{ey-FLP.B} NA P{ey-FLP.N} NA P{ey-FLP.U} NA P{ey-GAL80.3.5} NA P{p6.ey} NA P{p14.ey} NA P{UAS.ey1-545.enRD} NA P{UAS-ey::eyg.EEEGEE} NA P{UAS-ey::eyg.EEEGEG} NA P{UAS-ey::eyg.EEEGGG} NA P{UAS-ey::eyg.EEGEEE} NA P{UAS-ey::eyg.EEGEGE} NA P{UAS-ey::eyg.EEGGGE} NA P{UAS-ey::eyg.EEGGGG} NA P{UAS-ey::eyg.EGGGGE} NA P{UAS-ey::eyg.EGGGGG} NA P{UAS-ey::eyg.GEEEEE} NA P{UAS-ey::eyg.GEEEEG} NA P{UAS-ey::eyg.GGEEEE} NA P{UAS-ey::eyg.GGEEEG} NA P{UAS-ey::eyg.GGEGEG} NA P{UAS-ey::eyg.GGGEGE} NA P{UAS-ey::eyg.GGGGEG} NA P{UAS-ey::eyg.GGGGGE} NA P{UAS-EYBB-toyCT} NA P{UAS-eyPD-TOYBB} NA P{UAS-Pax-6.mus} NA P{UAS-toyBB-EYBB} NA P{UAS-toyPD-EYBB} NA PBac{ey-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Doc{}ey2 NA flea{}eyR NA P{GT1}eyBG00784 NA P{RS3}eyCB-0242-3 NA PBac{5HPw+}eyB320 NA PBac{RB}eye02123 NA PBac{RB}eye04282 NA PBac{RB}eye04624 NA insertion of enhancer trap binary system Mi{ET1}eyMB00784 No P{GawB}eyOK107 No
Gene Ontology: Function, Process & Cellular Component ( 22 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with so (Zhang et al., 2006) inferred from physical interaction with UniProtKB:Q9VBW6 (assigned by UniProtKB) (Curtiss et al., 2007) inferred from physical interaction with UniProtKB:Q9VBW9 (assigned by UniProtKB) (Curtiss et al., 2007) RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity inferred from direct assay (Blanco et al., 2005, Clements et al., 2008) sequence-specific DNA binding inferred from mutant phenotype (Zhang et al., 2006)
Biological Process
CV term Evidence References
adult walking behavior inferred from mutant phenotype (Callaerts et al., 2001) brain development inferred from mutant phenotype (Callaerts et al., 2001) brain morphogenesis inferred from mutant phenotype (Furukubo-Tokunaga et al., 2009) central complex development inferred from mutant phenotype (Clements et al., 2009) compound eye development inferred from mutant phenotype (Clements et al., 2009) compound eye morphogenesis inferred from mutant phenotype (Callaerts et al., 2001, Yao and Sun, 2005) glial cell migration inferred from mutant phenotype (Hummel et al., 2002) mushroom body development inferred from expression pattern AND inferred from mutant phenotype (Noveen et al., 2000) inferred from mutant phenotype (Callaerts et al., 2001, Clements et al., 2009, Furukubo-Tokunaga et al., 2009) neuron differentiation inferred from mutant phenotype (Clements et al., 2008) photoreceptor cell fate specification inferred from mutant phenotype (Anderson et al., 2006) positive regulation of multicellular organism growth inferred from mutant phenotype (Clements et al., 2008) positive regulation of transcription, DNA-dependent inferred from direct assay (Clements et al., 2008) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Blanco et al., 2005, Yao and Sun, 2005) inferred from mutant phenotype (Clements et al., 2008) regulation of insulin-like growth factor receptor signaling pathway inferred from mutant phenotype (Clements et al., 2008)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with mouse Pax6 (FlyBase, 1992-) traceable author statement (Gibson and Schubiger, 2001)
Biological Process
CV term Evidence References
compound eye development non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) traceable author statement (Curtiss et al., 2002) eye-antennal disc morphogenesis traceable author statement (Martini et al., 2000) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with mouse Pax6 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) traceable author statement (Martini et al., 2000) transcription factor complex inferred from sequence or structural similarity with mouse Pax6 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
ey - CtBP anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation (Hoang et al., 2010) ey - dan anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation (Hoang et al., 2010) ey - exd pull down, autoradiography (Bessa et al., 2002) ey - hth pull down, autoradiography (Bessa et al., 2002)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ey allele Gene References ey1 eyg (Hunt, 1970) gish (Hummel et al., 2002) Mpe (Hughes and Shelton, 1980) ey2 dac (Martini et al., 2000) eyg (Jang et al., 2003) pb (Benassayag et al., 2003) so (Pignoni, 2001.1.26) toy (Czerny et al., 1999) eyD1Da pb (Callaerts et al., 2001, Benassayag et al., 2003) eyD BacA\p35 (Kronhamn et al., 2002) eyg (Jang et al., 2003) eyEH pb (Benassayag et al., 2003) eyJ5.71 toy (Punzo et al., 2002) eyJD pb (Callaerts et al., 2001, Benassayag et al., 2003) eyScer\UAS.cHa Antp (Plaza et al., 2001) brk (Kango-Singh et al., 2003) ci (Kango-Singh et al., 2003) dac (Chen et al., 1999) dpp (Chen et al., 1999, Curtiss and Mlodzik, 2000, Kango-Singh et al., 2003) eya (Bonini et al., 1997, Halder et al., 1998, Chen et al., 1999) eyg (Jang et al., 2003) fng (Dominguez et al., 2004) gsb (Jiao et al., 2001) hh (Kango-Singh et al., 2003) so (Halder et al., 1998) unspecified L (Singh et al., 2005) ld   nej (Anderson et al., 2005) pb (Benassayag et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68643 DroID - A comprehensive database of gene and protein interactions. • FBgn0005558 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43812 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O18381
Orthologs
OrthoDB Orthologs (95) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JDHS8 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6J6QM1 Arthropod inclusive ortholog search EOG6Z08P7 Metazoa inclusive ortholog search EOG6C00XD
Orthologs in Drosophila Species (EOG6JDHS8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\ey     Drosophila simulans   Dsim\ey     Drosophila sechellia   Dsec\ey Y   Drosophila erecta   Dere\GG16399 Y   Drosophila yakuba   Dyak\GE14559 Y   Drosophila ananassae   Dana\GF22818 Y   Drosophila pseudoobscura pseudoobscura   Dpse\ey Y   Drosophila persimilis   Dper\ey Y   Drosophila willistoni   Dwil\GK13702 Y   Drosophila virilis   Dvir\ey Y   Drosophila mojavensis   Dmoj\GI14081 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6J6QM1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50342   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012484   Atta cephalotes Leafcutter ant  Acep\ACEP20913   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16683   Linepithema humile Argentine ant  Lhum\LH21997   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16104   Solenopsis invicta Red fire ant  Sinv\SINV17240   Acyrthosiphon pisum Pea aphid  Apim\ACYPI067710   Tribolium castaneum Red flour beetle  Tcas\TC008176
Orthologs in non-Insect Arthropods (EOG6Z08P7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\STAG1 Y Daphnia pulex Water flea  Dpux\JGI_V11_249978 Y Daphnia pulex Water flea  Dpux\EYELESS Y Daphnia pulex Water flea  Dpux\JGI_V11_122807 Y Ixodes scapularis Deer tick  Isca\ISCW021772 Y Ixodes scapularis Deer tick  Isca\ISCW006352 Y
Orthologs in non-Arthropod Metazoa (EOG6C00XD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pax-3 Y Caenorhabditis elegans Nematode  Cele\alr-1 Y Caenorhabditis elegans Nematode  Cele\pax-1 Y Caenorhabditis elegans Nematode  Cele\pax-2 Y Caenorhabditis elegans Nematode  Cele\egl-38 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014539gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006786gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000276gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019338gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018351gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006787gn Y Danio rerio Zebrafish  Drer\pax7b Y Danio rerio Zebrafish  Drer\ENSDARG00000075896 Y Danio rerio Zebrafish  Drer\ENSDARG00000073814 Y Danio rerio Zebrafish  Drer\pax3a Y Danio rerio Zebrafish  Drer\pax7a Y Danio rerio Zebrafish  Drer\pax3b Y Danio rerio Zebrafish  Drer\ENSDARG00000091353 Y Danio rerio Zebrafish  Drer\arx Y Danio rerio Zebrafish  Drer\pax8 Y Danio rerio Zebrafish  Drer\pax2b Y Danio rerio Zebrafish  Drer\ENSDARG00000008203 Y Danio rerio Zebrafish  Drer\pax9 Y Danio rerio Zebrafish  Drer\pax6a Y Danio rerio Zebrafish  Drer\pax5 Y Danio rerio Zebrafish  Drer\pax2a Y Xenopus tropicalis Western clawed frog  Xtro\pax1 Y Xenopus tropicalis Western clawed frog  Xtro\pax9 Y Xenopus tropicalis Western clawed frog  Xtro\pax2 Y Xenopus tropicalis Western clawed frog  Xtro\pax7 Y Xenopus tropicalis Western clawed frog  Xtro\arx Y Xenopus tropicalis Western clawed frog  Xtro\pax3 Y Xenopus tropicalis Western clawed frog  Xtro\pax6 Y Xenopus tropicalis Western clawed frog  Xtro\pax5 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032534 Y Xenopus tropicalis Western clawed frog  Xtro\pax8 Y Gallus gallus Domestic chicken  Ggal\PAX2 Y Gallus gallus Domestic chicken  Ggal\PAX7 Y Gallus gallus Domestic chicken  Ggal\PAX5 Y Gallus gallus Domestic chicken  Ggal\PAX6 Y Gallus gallus Domestic chicken  Ggal\PAX9 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000005246 Y Mus musculus House mouse  Mmus\Pax8 Y Mus musculus House mouse  Mmus\Pax9 Y Mus musculus House mouse  Mmus\Pax5 Y Mus musculus House mouse  Mmus\Pax1 Y Mus musculus House mouse  Mmus\Pax7 Y Mus musculus House mouse  Mmus\Pax3 Y Mus musculus House mouse  Mmus\Pax2 Y Mus musculus House mouse  Mmus\Arx Y Mus musculus House mouse  Mmus\Pax4 Y Mus musculus House mouse  Mmus\Pax6 Y Rattus norvegicus Norway rat  Rnor\Pax7 Y Rattus norvegicus Norway rat  Rnor\Pax1 Y Rattus norvegicus Norway rat  Rnor\Pax4 Y Rattus norvegicus Norway rat  Rnor\Pax3 Y Rattus norvegicus Norway rat  Rnor\RGD1565236 Y Rattus norvegicus Norway rat  Rnor\Pax8 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000004410 Y Rattus norvegicus Norway rat  Rnor\Pax2 Y Rattus norvegicus Norway rat  Rnor\Pax9 Y Homo sapiens Human  Hsap\PAX3 Y Homo sapiens Human  Hsap\PAX7 Y Homo sapiens Human  Hsap\PAX5 Y Homo sapiens Human  Hsap\ENSG00000125618 Y Homo sapiens Human  Hsap\ENSG00000106331 Y Homo sapiens Human  Hsap\PAX6 Y Homo sapiens Human  Hsap\PAX1 Y Homo sapiens Human  Hsap\Pax9 Y
Human Orthologs (8)
Gene OMIM HGNC Hsap\PAX3     Hsap\PAX7     Hsap\PAX5     Hsap\ENSG00000125618     Hsap\ENSG00000106331     Hsap\PAX6     Hsap\PAX1     Hsap\Pax9
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\ey Drosophila erecta Dere\GG16399 Drosophila yakuba Dyak\GE14559 Drosophila ananassae Dana\GF22818 Drosophila pseudoobscura pseudoobscura Dpse\ey Drosophila persimilis Dper\ey Drosophila willistoni Dwil\GK13702 Drosophila virilis Dvir\ey Drosophila mojavensis Dmoj\GI14081 Drosophila grimshawi Dgri\GH24002
Stocks & Reagents
Stocks Listed in FlyBase ( 66 )
Bloomington	647 ey1 648 ey2 649 ey4 4229 ci1 eyR
Harvard	- PBac{RB}eye02123 - PBac{RB}eye04282 - PBac{RB}eye04624
Kyoto	106025 ey1 106026 ey2 106027 ey4 107646 ci1 eyR
VDRC	v106628 P{KK107100}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR06K04 BACR16H06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 20 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01157 IP14880
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	57803 80581 146040 148918 173959 CK01.2B.H5 CK01.62D.B6 CK01.87C.D3 EK050639 EK069114 EK178836 EK185107 EK249058 EK255145 EP22203 IP14980 IP15080 IP15180
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005558 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43812
Antibody Information
	monoclonal (Clements et al., 2008) polyclonal (Halder et al., 1998)
Other Information
Discoverer
	Hoge, May 1914.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: ey CG1464 (Zhong, 1999.11)
Source for database merge of
Additional comments	ey2 is the most frequently used allele. Four lethal alleles, formerly l(4)10 = l(4)33, assigned to the ey locus by Hochman (1971); they produce a low incidence of escapers with reduced eyes and but partially complement eyR.
Other Comments
	ey induces expression of dac. (Anderson et al., 2006) The DNA binding activity of ey relies on the PAI and L regions of the PD domain. (Yao and Sun, 2005) pb and ey have antagonistic roles in head development. (Benassayag et al., 2003) ey collaborates with hh and dpp signalling in eye induction. (Kango-Singh et al., 2003) gish, so, ey and hh act in the posterior region of the eye disc to prevent precocious glial cell migration. (Hummel et al., 2002) ey is not responsible for the development of head structures derived from the antennal disc, but is primarily required to inhibit cell death and to promote eye development. (Kronhamn et al., 2002) Overexpression of ey produces a phenotype in the embryonic nervous system. (Kammermeier et al., 2001) ey has a function in the structural development of the mushroom body. (Kurusu et al., 2000) ey and dac may have a role in axon pathway selection during embryogenesis. (Noveen et al., 2000) ey and dac do not seem to regulate each other's expression in the developing mushroom body. (Noveen et al., 2000) A single amino acid substitution in the ey protein is able to change the DNA-binding affinity of its paired domain to that of toy. (Czerny et al., 1999) toy acts upstream of ey in the control of eye development. Despite the similarity in structure and expression of toy and ey, normal expression of toy cannot compensate for the loss of ey function. (Czerny et al., 1999) ey protein activates transcription of so by direct interaction with an eye-specific enhancer in the long intron of so. (Niimi et al., 1999) so and eya are two mediators of the eye inducing activity of ey. ey appears to induce the initial expression of so and eya in the eye disc. so and eya then participate in a positive feedback loop that regulates the expression of all three genes. In the embryonic head, however, so acts in parallel to ey and toy. The epistatic relationships among the corresponding vertebrate homologs are very similar to those observed in Drosophila. (Halder et al., 1998) tsh and ey induce the expression of each other, acting in a gene network that functions to specify eye identity. (Pan and Rubin, 1998) eya is essential for ey function. (Bonini et al., 1997) dac and ey induce the expression of each other and dac is required for ectopic retinal development driven by ey misexpression. Results suggest dac and ey are likely to function together in the control of retinal cell-fate specification at the early stages of eye development. (Shen and Mardon, 1997) The pattern of ey expression during eye and Bolwig organ development has been analysed. ey directly regulates ninaE expression in photoreceptor cells. (Sheng et al., 1997) Used in an investigation to address the relationship between retrotransposons and retroviruses and the coadaptation of these retroelements to their host genomes. Results indicate retrotransposons are heterogeneous in contrast to retroviruses, suggesting different modes of evolution by slippage-like mechanisms. (Terzian et al., 1997) Targeted expression of ey in various imaginal disc primordia results in ectopic eyes on the wings, legs and antennae. The ectopic eyes appear morphologically normal and consist of groups of fully differentiated ommatidia with a complete set of photoreceptor cells. Similar ectopic eyes can be induced by targeted expression of the Mmus\Pax6 gene. (Halder et al., 1995) Comparisons of early development to that in other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events. (Patel, 1994) Eye size variably reduced depending on allele (see table); expressivity more variable for some alleles than for others. Tetragonal packing of facets and face-centered tetragonal bristle lattice (eyR) in place of hexagonal array of wild type (Hartman and Hayes, 1971); associated with a failure of the horizontal secondary pigment cell to expand to give rise to the horizontal boundaries between ommatidia (Ready, Hanson and Benzer, 1976). Some ey2 flies show duplications of antennae or antennal segments with or without duplication of aristae; extra maxillary structures also observed (Shatouri, 1963). Optical discs reduced in size (ey<up>1) Richards and Farrow, 1922; (ey2) Medvedev, 1935; Medvedev, 1935; Steinberg, 1944; (ey4) Chen, 1929</up>. Degenerating cells abundantly observed in the optic discs of third instar larvae of ey2 (Fristrom, 1969; Ransom, 1979). Expressivity sensitive to genetic background (ey<up>4) Spofford, 1956; (ey1, ey2, ey4, eyK) Hunt and Burnet, 1969</up>. Phenotype also responds to developmental temperature, larval density, and composition of medium. Eye size reported to increase with increased temperature in e1 (Baron, 1935) and eyK (Sang and Burnet, 1963) but to decrease in eyW (Meyer, 1959). Phenotype less extreme in flies raised under crowded conditions at 18oC but not 25oC (Sang and Burnet, 1963; see also Chester, 1971). Eye size of four alleles increased by cholesterol deprivation and decreased by dietary deficiencies in thiamine or RNA (Hunt and Burnet, 1969). Larval feeding of lactamide to ey2 causes decreased eye size, which is of opposite sign from its effect on B (Grant and Rapport, 1980); no such effect of lactamide on eyK observed by Sang and Burnet (1963). ey2 flies exhibit normal visual orientation in Y maze (Bulthoff, 1982). ey2, ey4 and eyK in combination with eyg (3-35.5) results in almost complete curtailment of eye development and synthetic lethality, with the major lethal crisis at the end of the pupal stage and a minor lethal phase at pupation; rare surviving adults have brain in anterior thorax (Hunt, 1970).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079889 NM_166789 NM_001014693 NM_001014694 RefSeq (Proteins) • NP_524628 NP_726607 NP_001014693 NP_001014694 DDBJ / EMBL / GenBank • AAD54001 AAF59318 AAF59318.1 AAM17959 AAM17960 AAM17961 AAM17962 AAM17963 AAM17964 AAM17965 AAM17966 AAM17967 AAM17968 AAN06513 AAN06513.1 AAX52512 AAX52513 AC010576 AC099309 AF089733 AF433696 AF433697 AF433698 AF433699 AF433700 AF433701 AF433702 AF433703 AF433704 AF433705 AI062092 AJ131630 CAA10461 CAA56037 CAA56038 CZ479948 X79492 X79493 Entrez Gene - A searchable database of RefSeq genes. • 43812 UniProtKB/Swiss-Prot • O18381 UniProtKB/TrEMBL • O96791 Q9U8F7 Q59DQ1 Q59DQ2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Paired domain (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix DNA-binding domain (IPR011991) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH01157
Linkouts
	BioGRID - A database of protein and genetic interactions • 68643 DroID - A comprehensive database of gene and protein interactions. • FBgn0005558 DRSC - Results from RNAi screens. • FBgn0005558 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005558 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1464-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005558 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43812 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/eyeless.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43812 modMine - Data generated by the modENCODE project. • FBgn0005558 REDfly - A database of transcriptional regulatory elements. • FBgn0005558 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O18381
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG1464 (Whitfield, 2000.9.20, Datta et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1) DPax-6 (Walldorf et al., 1994) ey (Halder et al., 1998, Urbach et al., 2006, Zhang et al., 2005, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Weanser, 2007, Kumar and Datta, 2007, Kumar and Anderson, 2007, Oakley et al., 2006, Kronhamn et al., 2002, Onuma et al., 2002, Fic et al., 2007, Sultana et al., 2011, Roederer et al., 2005, Roignant et al., 2010, Podemski et al., 2004, Kobayashi et al., 2006, Anderson et al., 2006, Friedrich, 2006, Apitz et al., 2005, Duong et al., 2008, Yoshioka et al., 2007, Jacobsson et al., 2008, Chen et al., 2008, Weasner and Kumar, 2008, Anderson and Kumar, 2008, Von Ohlen et al., 2007, Luque and Milan, 2007, Datta et al., 2011, Wang et al., 2007, McDermott and Kliman, 2008, Weasner et al., 2007, Yao et al., 2008, Morante and Desplan, 2008, Clements et al., 2008, Lee et al., 2009, Firth and Baker, 2009, Curtiss et al., 2007, Braid and Verheyen, 2008, Kurusu et al., 2009, Bossuyt et al., 2009, Noor and Kliman, 2003, Punzo et al., 2004, Choi et al., 2005, Clements et al., 2008, Plaza et al., 2008, Zeitlinger et al., 2007, Clements et al., 2009, Brás-Pereira and Casares, 2008, Furukubo-Tokunaga et al., 2009, Datta et al., 2009, Gutierrez-Aviño et al., 2009, Ostrin et al., 2006, Lopes and Casares, 2010, Salzer and Kumar, 2010, Baig et al., 2010, Schulze et al., 2009, Blanco et al., 2010, Salzer et al., 2010, Aerts et al., 2010, Morante et al., 2011, Kearse et al., 2011, Brockmann et al., 2011, Jacobsson et al., 2009, Sprecher et al., 2007, Michaut et al., 2011, Papadopoulos et al., 2010, Nfonsam et al., 2012, Stephan et al., 2011, Kopyl et al., 2011, Wang and Sun, 2012, Kunz et al., 2012, Manning et al., 2012, Spokony and White, 2012.11.14) Ey (Kozmik, 2005, Jang and Sun, 2001, Zhang et al., 2006, Lan et al., 2007, Wang et al., 2007, Aerts et al., 2007, Karcavich and Doe, 2005, Li et al., 2008, Zhang et al., 2011, Siegrist et al., 2010, Papadopoulos et al., 2010) EY (Adachi et al., 2008) Ey/Pax6 (Curtiss and Mlodzik, 2005) eye (Galliot et al., 1999, Balczarek et al., 1997) EYEL (Bassett et al., 1997) l(4)33 (Hochman, 1976, Hochman, 1974, Hochman, 1971, ) l(4)102CDh   l(4)102CDr   OK107 (Das et al., 2011) Pax-6 (Stebbins, 2004, Jacobsson et al., 2008, Morante and Desplan, 2008) Pax6 (Kenyon et al., 2003, Morgan, 2004, Anonymous, 2002, Pichaud et al., 2001, Hodin, 2000, Curtiss and Mlodzik, 2005, Blanco et al., 2010) pax6 (Pichaud and Desplan, 2002, Brown, 2000, Sheng et al., 1996)
Name Synonym	eyeless (Xu, 1998.8.25, Schwartz and Pirrotta, 2007, Legent et al., 2007, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Weanser, 2007, Kumar and Datta, 2007, Kumar and Anderson, 2007, Fic et al., 2007, Sultana et al., 2011, Roederer et al., 2005, Fernald, 2006, Friedrich, 2006, Duong et al., 2008, Yoshioka et al., 2007, Wang and Sun, 2008, Jacobsson et al., 2008, Chen et al., 2008, Legent et al., 2008, Von Ohlen et al., 2007, Li and Baker, 2007, Luque and Milan, 2007, Wang et al., 2007, Morante and Desplan, 2008, Clements et al., 2008, Bossuyt et al., 2009, Noor and Kliman, 2003, Clements et al., 2008, Zeitlinger et al., 2007, Clements et al., 2009, Furukubo-Tokunaga et al., 2009, Gutierrez-Aviño et al., 2009, Ostrin et al., 2006, Lopes and Casares, 2010, Salzer and Kumar, 2010, Baig et al., 2010, Pereanu et al., 2007, Schulze et al., 2009, Blanco et al., 2010, Voolstra et al., 2010, Kearse et al., 2011, Jacobsson et al., 2009, Papadopoulos et al., 2010, Yang et al., 2012, Stephan et al., 2011, Maclellan et al., 2012) Eyeless (Zhang et al., 2005, Zhang et al., 2006, Aerts et al., 2007, Aerts et al., 2007, Karcavich and Doe, 2005, Li et al., 2008, Zhang and Pignoni, 2008, Adachi et al., 2008, Grover et al., 2009, Siegrist et al., 2010, Aerts et al., 2010, Morante et al., 2011, Wang and Sun, 2012) tumor-head-63
Secondary FlyBase IDs
	FBgn0000616 FBgn0004525 FBgn0004547 FBgn0010156
References ( 494 )
Generate a list of	All references relating to this gene ( 494 )
List References by type	Research paper  ( 250 ) Supplementary material  ( 5 ) Review  ( 85 ) Personal communication to FlyBase  ( 20 ) Abstract  ( 111 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 4 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Book  ( 2 ) Conference report  ( 4 ) Stock list  ( 1 ) Letter  ( 2 ) Book review  ( 1 ) Interview  ( 1 )
Recent research papers ( 22 )
	Henry et al., 2012, Nucleic Acids Res. 40(19): 9691--9704 Cell type-specific genomics of Drosophila neurons. [FBrf0219710] Kunz et al., 2012, Development 139(14): 2510--2522 Origin of Drosophila mushroom body neuroblasts and generation of divergent embryonic lineages. [FBrf0218649] Maclellan et al., 2012, Heredity 108(3): 203--210 Dietary stress does not strengthen selection against single deleterious mutations in Drosophila melanogaster. [FBrf0217530] Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Okamoto et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(7): 2406--2411 Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression. [FBrf0217470] Vesala et al., 2012, Insect Mol. Biol. 21(1): 107--118 Cold tolerance and cold-induced modulation of gene expression in two Drosophila virilis group species with different distributions. [FBrf0217233] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Wang and Sun, 2012, Development 139(18): 3413--3421 Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. [FBrf0219201] Yang et al., 2012, Genome Res. 22(11): 2199--2207 The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species. [FBrf0219877] Brockmann et al., 2011, Dev. Dyn. 240(1): 75--85 Regulation of ocellar specification and size by twin of eyeless and homothorax. [FBrf0212641] Das et al., 2011, Neural Syst. Circuits 1(1): 4 Identification and analysis of a glutamatergic local interneuron lineage in the adult Drosophila olfactory system. [FBrf0217450] Datta et al., 2011, Evol. Dev. 13(1): 58--71 Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs. [FBrf0212714] Hens et al., 2011, Nat. Methods 8(12): 1065--1070 Automated protein-DNA interaction screening of Drosophila regulatory elements. [FBrf0216759] Kearse et al., 2011, Nucleic Acids Res. 39(7): 2701--2716 Expression of ribosomal protein L22e family members in Drosophila melanogaster: rpL22-like is differentially expressed and alternatively spliced. [FBrf0213492] Kopyl et al., 2011, Russ. J. Genet. 47(8): 907--911 The influence of morphogene Wg on the formation of an ectopic eye in Drosophila melanogaster. [FBrf0218799] Kopyl et al., 2011, Genetika, Moscow 47(8): 1026--1031 [The influence of morphogene Wg on the formation of an ectopic eye in Drosophila melanogaster]. [FBrf0216261] Michaut et al., 2011, Dev. Growth Differ. 53(9): 982--993 Analyzing the function of a hox gene: An evolutionary approach. [FBrf0216990] Morante et al., 2011, Development 138(4): 687--693 Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6. [FBrf0212874] Stephan et al., 2011, Mol. Biol. Cell 22(21): 4079--4092 Membrane-targeted WAVE mediates photoreceptor axon targeting in the absence of the WAVE complex in Drosophila. [FBrf0216499] Sultana et al., 2011, Nucleic Acids Res. 39(9): 3543--3557 A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. [FBrf0213641] Zhang et al., 2011, PLoS ONE 6(7): e22278 Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...