FlyBase Gene Report: Dmel\ey

presumptive embryonic/larval central nervous system

(Kobayashi et al., 2006)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Quiring et al., 1994)

eye-antennal disc primordium

(Quiring et al., 1994)

embryonic stage 9 -- 10

procephalic neurogenic region & embryonic ocular segment | restricted

(Urbach and Technau, 2003)

stage 2 neuroblast | segmentally repeated

(Noveen et al., 2000)

central brain primordium

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 9 -- 11

protocerebral neuroblast | subset

(Urbach and Technau, 2003)

tritocerebral neuroblast | subset

(Urbach and Technau, 2003)

procephalic neurogenic region & embryonic intercalary segment | restricted

(Urbach and Technau, 2003)

deutocerebral neuroblast | subset

(Urbach and Technau, 2003)

procephalic neurogenic region & embryonic antennal segment | restricted

(Urbach and Technau, 2003)

embryonic stage 9 -- 17

embryonic VNC neuromere | segmentally repeated

(Kammermeier et al., 2001)

embryonic stage 9 -- first instar larval stage

neuroblast MBp

(Noveen et al., 2000)

embryonic stage 10

neuroblast MBp

(Daniel et al., 1999)

eye-antennal disc primordium

(Daniel et al., 1999)

embryonic stage 10 -- 16

larval ventral nerve cord | segmentally repeated

(Czerny et al., 1999)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

mushroom body primordium

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012, Czerny et al., 1999)

embryonic primordium of adult eye

(Fisher et al., 2012)

mushroom body primordium

Comment: reported as embryonic central brain mushroom body

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 14 -- 17

embryonic brain

(Kammermeier et al., 2001)

embryonic stage 15

embryonic brain

(Hauck et al., 1999)

larval ventral nerve cord | segmentally repeated

(Hauck et al., 1999)

eye-antennal disc primordium

(Hauck et al., 1999)

eye-antennal disc | anterior

(Quiring et al., 1994)

(Noveen et al., 2000)

(Czerny et al., 1999)

(Kobayashi et al., 2006)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Kronhamn et al., 2002)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12

Bolwig organ

(Sheng et al., 1997)

embryonic stage 16 -- 17

Bolwig organ

(Sheng et al., 1997)

(Sheng et al., 1997)

adult head

(Sheng et al., 1997)

Additional Descriptive Data

Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1, d2; deuterocerebrum - d4, v6, v7; protocerebrum - ad7, cd2, cd14, cv6, cv7, cv9, pd12, pd18, pd20, pv2

(Urbach and Technau, 2003)

Developmental northern blots show that transcript can be detected throughout development.

(Kronhamn et al., 2002)

ey is expressed in a cluster of approximately 10-12 cells beginning at stage 9 of embryogenesis, which correspond to the mushroom body neuroblasts. As the mushroom body neuroblasts delaminate they maintain ey expression, whereas expression diminishes in ectodermal cells that stay on the surface. ey is also expressed in a small group of neuroblasts in the deutocerebrum and tritocerebrum and in segmentally reiterated groups of three SII neuroblasts in the ventral nerve cord. Levels of expression are noted to decline by embryogenesis stage 13.

(Noveen et al., 2000)

ey is expressed in mushroom body neuroblasts and in the eye disc primordium at embryonic stage 10.

(Daniel et al., 1999)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

larval outer optic anlage | restricted

(Morante et al., 2011)

cell body rind of adult medulla

(Morante et al., 2011)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

neuroblast NB3-4

(Lacin and Truman, 2016)

neuroblast NB4-2

(Lacin and Truman, 2016)

neuroblast NB4-3

(Lacin and Truman, 2016)

neuroblast NB5-3

(Lacin and Truman, 2016)

neuroblast NB7-3

(Lacin and Truman, 2016)

embryonic stage -- larval stage

(Lacin and Truman, 2016)

neuroblast NB3-4

(Lacin and Truman, 2016)

neuroblast NB4-2

(Lacin and Truman, 2016)

neuroblast NB4-4

(Lacin and Truman, 2016)

embryonic stage 9 -- 10

procephalic neurogenic region & embryonic ocular segment | restricted

(Urbach and Technau, 2003)

embryonic stage 11 -- 17

embryonic VNC neuromere | segmentally repeated

(Kammermeier et al., 2001)

embryonic deutocerebrum | restricted

(Kammermeier et al., 2001)

embryonic protocerebrum | restricted

(Kammermeier et al., 2001)

embryonic tritocerebrum | restricted

(Kammermeier et al., 2001)

embryonic stage 17

embryonic/larval mushroom body

(Kraft et al., 2016)

larval stage

medulla forming neuroblast | subset

(Li et al., 2013)

neuron | subset of medulla anlage

(Li et al., 2013)

neuroblast NB4-3

(Lacin and Truman, 2016)

first instar larval stage

pedunculus of larval mushroom body

Comment: 24 hours after hatching

(Kraft et al., 2016)

calyx of larval mushroom body

Comment: 24 hours after hatching

(Kraft et al., 2016)

medial lobe of larval mushroom body

Comment: 24 hours after hatching

(Kraft et al., 2016)

vertical lobe of larval mushroom body

Comment: 24 hours after hatching

(Kraft et al., 2016)

second instar larval stage -- third instar larval stage

(Bessa et al., 2002)

medulla forming neuroblast | subset

(Suzuki et al., 2013)

ganglion mother cell | subset of larval outer optic anlage

(Suzuki et al., 2013)

adult optic lobe neuron | subset of larval outer optic anlage

(Suzuki et al., 2013)

larval optic neuroblast

(Southall et al., 2013)

larval outer optic anlage | restricted

(Morante et al., 2011)

eye disc anterior to the morphogenetic furrow | restricted

(Bessa et al., 2002)

pharate adult stage P9

Comment: 72 hours APF

(Kraft et al., 2016)

adult insulin secreting cell of pars intercerebralis

(Siegrist et al., 2010)

(Clements et al., 2008)

Additional Descriptive Data

ey-protein is expressed in the developing larval medulla in lateral neuroblasts adjacent to l(1)sc-positive neuroepithelium and gradually weakened in neuroblasts located in more medial regions. It is co-expressed with klu-protein except for the most lateral neuroblasts. ey-protein persists in ganglion mother cells and neurons of the developing medulla.

(Suzuki et al., 2013)

The expression of ey, ap, and Dll were compared in outer optic lobes (OPC) starting in late third instar larvae. At this stage they were expressed as three distinct cell populations. In anterior sections, the three genes are expressed a three parallele stripes of cells that represent rows of neurons that emerge from the OPC. They correspond to progeny from the youngest to oldest neuroblasts. In middle sections, Dll-positive cells are generated in the progeny of the oldest neuroblasts, with ey-positive and ap-positive cells often placed below Dll-positive (in cells that had emerged earlier from the these neuroblasts). By the beginning of pupation, the number of cells origination from the OPC increased. A major reorganization of optic lobe structure occurs around P20 such that the three stripes are no longer distinguishable and the three cell populations are extensively interspersed within the adult medulla cortex.

(Morante et al., 2011)

ey protein is first detected in the CNS at embryonic stage 10 and corresponds to the downregulation of ind. The expression domains of ey and ind are mutually exclusive during stages 10 and 11. ey is primarily expressed in row 3-5 neuroblasts at late stage 10 and is not detected in en-positive neuroblasts.

(Von Ohlen et al., 2007)

Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d1, d2; deuterocerebrum - d4, v6, v7; protocerebrum - ad7, cd2, cd14, cv6, cv7, cv9, pd12, pd18, pd20, pv2

(Urbach and Technau, 2003)

ey protein is expressed in all cells of the second instar eye disc. By late third instar, ey protein is expressed in the eye disc anterior to the morphogenetic furrow, but not in the anterior-most part of the eye disc, where it contacts the antennal disc.

(Bessa et al., 2002)

Marker for

gonadal sheath proper primordium

(Wang and Sun, 2012)

(Jemc et al., 2012)

(Siegrist et al., 2010)

neuroblast NB3-2

(Lacin and Truman, 2016)

neuroblast NB3-4

(Lacin and Truman, 2016)

neuroblast NB4-2

(Lacin and Truman, 2016)

neuroblast NB4-3

(Lacin and Truman, 2016)

neuroblast NB4-4

(Lacin and Truman, 2016)

neuroblast NB5-3

(Lacin and Truman, 2016)

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: Mi{Trojan-p65AD.0}ey^{MI08729-Tp65AD.0}

Stage

Tissue/Position (including subcellular localization)

Reference

Notch OFF hemilineage neuron of NB3-2 lineage neuron

Comment: when combined with Mi{Trojan-GAL4DBD.0}Dbx^{MI05316-TG4DBD.0}

(Lacin et al., 2020)

Reporter: P{ey1x-GAL4.Exel}

Stage

Tissue/Position (including subcellular localization)

Reference

(Lee and Thomas, 2011)

Reporter: P{ey3.5-GAL4.Exel}

Stage

Tissue/Position (including subcellular localization)

Reference

eye disc posterior to the morphogenetic furrow

(Shwartz et al., 2013)

(Shwartz et al., 2013)

(Bose et al., 2006)

Reporter: P{ey-GAL4.S}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic primordium of adult eye

(Robertson et al., 2002, Lai and Rubin, 2001, Lai et al., 2000)

eye

(Lyko et al., 1999)

Reporter: P{ey-lacZ.C}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

(Czerny et al., 1999)

eye disc morphogenetic furrow

(Czerny et al., 1999)

eye disc posterior to the morphogenetic furrow

(Czerny et al., 1999)

(Czerny et al., 1999)

Reporter: P{ey-lacZ.mut}

Stage

Tissue/Position (including subcellular localization)

Reference

eye disc morphogenetic furrow

(Czerny et al., 1999)

eye disc posterior to the morphogenetic furrow

(Czerny et al., 1999)

(Czerny et al., 1999)

Reporter: P{GAL4-ey.H}

Stage

Tissue/Position (including subcellular localization)

Reference

(Hazelett et al., 1998)

Reporter: P{GawB}OK107

Stage

Tissue/Position (including subcellular localization)

Reference

larval outer optic anlage | restricted

(Morante et al., 2011)

cell body rind of adult medulla

(Morante et al., 2011)

larval stage -- adult stage

first instar larval stage -- adult stage

(Nicolai et al., 2003)

late third instar larval stage -- prepupal stage P1

(Ng and Luo, 2004)

gamma Kenyon cell

(Hoopfer et al., 2008)

medulla forming neuroblast | subset

(Suzuki et al., 2013)

ganglion mother cell | subset of larval outer optic anlage

(Suzuki et al., 2013)

adult optic lobe neuron | subset of larval outer optic anlage

(Suzuki et al., 2013)

P-stage

adult mushroom body beta'-lobe

(Lee et al., 1999)

(Lee et al., 1999)

adult mushroom body alpha'-lobe

(Lee et al., 1999)

(Lee et al., 1999)

adult mushroom body gamma-lobe

(Lee et al., 1999)

(Lee et al., 1999)

(Watts et al., 2003)

pupal stage P6

(Kurusu et al., 2009)

pharate adult stage P8

(Kurusu et al., 2009)

adult antennal lobe local neuron

(Lee et al., 1999)

adult median bundle

(Agrawal et al., 2005)

(Chou et al., 2010)

gamma Kenyon cell

(Flybrain Neuron Database et al., 2018.6.28, Christiansen et al., 2011, Pauls et al., 2010, Tanaka et al., 2008)

calyx of adult mushroom body

(Tanaka et al., 2008)

adult mushroom body dorsal accessory calyx

(Tanaka et al., 2008)

alpha'/beta' middle Kenyon cell

(Flybrain Neuron Database et al., 2018.6.28, Tanaka et al., 2008)

alpha'/beta' anterior-posterior Kenyon cell

(Flybrain Neuron Database et al., 2018.6.28, Tanaka et al., 2008)

mushroom body alpha lobe posterior layer

(Tanaka et al., 2008)

mushroom body alpha lobe surface layer

(Tanaka et al., 2008)

mushroom body alpha lobe core layer

(Tanaka et al., 2008)

mushroom body beta lobe posterior layer

(Tanaka et al., 2008)

mushroom body beta lobe surface layer

(Tanaka et al., 2008)

mushroom body beta lobe core layer

(Tanaka et al., 2008)

Comment: strong expression

(Cavanaugh et al., 2014, Lin et al., 2013, Chen et al., 2012, Kobayashi et al., 2006, Agrawal et al., 2005, Zhu et al., 2003, Lee et al., 1999)

(Lee et al., 1999)

(Wu et al., 2010, Lee et al., 1999)

adult mushroom body | restricted

(Flybrain Neuron Database et al., 2018.6.28, Chou et al., 2010, Kurusu et al., 2009, Lee et al., 1999)

(Wu et al., 2010)

GABAergic local interneuron of the adult antennal lobe | subset

Comment: 54 of 103 labeled neurons

(Chou et al., 2010)

glutamatergic local interneuron of the adult antennal lobe | subset

Comment: 62 of 110 labeled neurons

(Chou et al., 2010)

Kenyon cell of calyx of adult mushroom body

(Christiansen et al., 2011)

Kenyon cell of calyx of adult mushroom body | restricted

(Christiansen et al., 2011)

alpha'/beta' Kenyon cell

(Christiansen et al., 2011, Pauls et al., 2010)

alpha/beta Kenyon cell

(Christiansen et al., 2011, Pauls et al., 2010)

adult insulin secreting cell of pars intercerebralis | subset

(Enell et al., 2010)

adult pars intercerebralis

(Cavanaugh et al., 2014, Enell et al., 2010, Aso et al., 2009)

neuron | subset of adult brain

(Chen et al., 2012)

eye

Comment: faint expression

(Chen et al., 2012)

ellipsoid body

Comment: faint expression

(Chen et al., 2012)

adult optic lobe | restricted

(Morante and Desplan, 2008)

medullary intrinsic neuron Mi4

(Morante and Desplan, 2008)

medullary intrinsic neuron Mi9

(Morante and Desplan, 2008)

medullary intrinsic neuron Mi3

(Morante and Desplan, 2008)

medullary intrinsic neuron Mi11

(Morante and Desplan, 2008)

distal medullary amacrine neuron Dm1

(Morante and Desplan, 2008)

distal medullary amacrine neuron Dm10

(Morante and Desplan, 2008)

proximal medullary amacrine neuron Pm2

(Morante and Desplan, 2008)

proximal medullary amacrine neuron PmLM7

(Morante and Desplan, 2008)

proximal medullary amacrine neuron Pm9-10

(Morante and Desplan, 2008)

transmedullary neuron Tm11

(Morante and Desplan, 2008)

transmedullary neuron Tm5

(Morante and Desplan, 2008)

transmedullary neuron Tm20

(Morante and Desplan, 2008)

transmedullary neuron Tm8

(Morante and Desplan, 2008)

transmedullary neuron Tm26

(Morante and Desplan, 2008)

transmedullary neuron Tm17

(Morante and Desplan, 2008)

transmedullary neuron Tm3-6

(Morante and Desplan, 2008)

transmedullary neuron TmR7 P and Y

(Morante and Desplan, 2008)

transmedullary neuron TmLM7

(Morante and Desplan, 2008)

transmedullary neuron TmLM8

(Morante and Desplan, 2008)

transmedullary Y neuron TmY5

(Morante and Desplan, 2008)

transmedullary Y neuron TmY5a

(Morante and Desplan, 2008)

adult mushroom body gamma-lobe

(Pauls et al., 2010, Lee et al., 1999)

adult mushroom body beta'-lobe

(Pauls et al., 2010, Lee et al., 1999)

adult mushroom body alpha'-lobe

(Pauls et al., 2010, Wu et al., 2010, Lee et al., 1999)

mushroom body | intense

(Aso et al., 2009)

lobula | faint

(Aso et al., 2009)

lobula plate | faint

(Aso et al., 2009)

adult lateral horn | faint

(Aso et al., 2009)

adult protocerebrum | faint | restricted

(Aso et al., 2009)

inferior neuropils | faint

(Aso et al., 2009)

adult deutocerebrum | faint

(Aso et al., 2009)

adult tritocerebrum

(Aso et al., 2009)

adult gnathal ganglion

(Aso et al., 2009)

adult brain | restricted

(Cavanaugh et al., 2014)

alpha/beta surface Kenyon cell

(Flybrain Neuron Database et al., 2018.6.28)

alpha/beta posterior Kenyon cell

(Flybrain Neuron Database et al., 2018.6.28)

(Pauls et al., 2010)

intermediate neuronal progenitor

(Pauls et al., 2010)

Comment: only expressed in 'old' secondary neuroblasts.

(Sullivan et al., 2019)

adult stage | male

(Blum et al., 2009)

adult mushroom body gamma-lobe

(Blum et al., 2009)

(Blum et al., 2009)

adult mushroom body alpha'-lobe

(Blum et al., 2009)

adult mushroom body beta'-lobe

(Blum et al., 2009)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ey in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\ey

View exonic expression by tissue for Dmel\ey

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005558

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43812/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005558

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005558

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005558

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1464

Flygut - An atlas of the Drosophila adult midgut

FBgn0005558

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 51 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 45 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of ey

Transgenic constructs containing regulatory region of ey

Aberrations (Deficiencies and Duplications) ( 21 )

Inferred from experimentation ( 21 )

Gene duplicated in

C(1;Y;4)d7

(Ahmad and Golic, 1998)

Dp(1;4)193

Dp(2;4)ey^D

(Hochman et al., 1964)

Dp(4;3)ey^D

(Tokunaga, 1969)

Gene not duplicated in

Dp(1;Y)su(f)⁺

(Gethmann, 1967)

Ts(1Lt;4Lt)w^mJ

Ts(2Lt;4Lt)b

(Morgan, 1947)

Gene not disrupted in

Df(4)G

(Kronhamn et al., 2002, Hochman et al., 1964)

Df(4)M101-4

(Hochman et al., 1964)

Df(4)spa³⁰

(Kronhamn et al., 2002)

Df(4)spa⁴⁷

(Kronhamn et al., 2002)

Df(4)spa⁶⁶

(Kronhamn et al., 2002)

Df(4)spa^m18

(Kronhamn et al., 2002)

Df(4)spa^m100

(Kronhamn et al., 2002)

T(1;4)sc^H

(Sousa-Neves, 2000, Sousa-Neves, 1999.11.10)

Gene disrupted in

Df(4)BA

(Benassayag et al., 2003, Kronhamn et al., 2002)

Df(4)C1-10a

(Podemski et al., 2004)

Df(4)ED6382

(Ryder and Roote, 2004.11.10)

Df(4)ED6384

(Ryder and Roote, 2004.11.10)

Df(4)J2

(Podemski et al., 2004, Callaerts et al., 2001)

Df(4)O2

(Kammermeier et al., 2001)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(4)J2)

ey^JD

lethal | heat sensitive

ey^hs.PH

lethal | male limited, with Scer\GAL4^Bx-MS1096

ey^{UAS.ORF.GW.Tag:HA}

lethal | male limited | cold sensitive, with Scer\GAL4^Bx-MS1096

ey^{UAS.ORF.GW.Tag:HA}

lethal | recessive

ey^D

lethal - all die before end of larval stage, with Scer\GAL4^ey-OK107

ey^UAS.cHa

lethal - all die before end of pupal stage

lethal - all die before end of pupal stage | recessive

lethal - all die during embryonic stage, with Scer\GAL4^hs.PB

ey^UAS.cHa

partially lethal (with Df(4)J2)

ey^D1Da

partially lethal (with ey^J5.71)

ey^JD

partially lethal (with ey^JD)

ey^J5.71

partially lethal | recessive

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

ey^GD1440

viable, with Scer\GAL4^Mef2.PR

ey^GD1440

viable, with Scer\GAL4^pnr-MD237

ey^GD1440

viable, with Scer\GAL4^tin.CΔ4

ey^GD1440

viable (with ey²)

viable (with ey^D1Da)

viable (with ey^J5.71)

ey^D1Da

viable (with ey^JD)

viable (with ey^R)

Sterility

Allele

fertile

ey^W

Other Phenotypes

Allele

abnormal eye color, with Scer\GAL4^lz-gal4

ey^UAS.cHa

abnormal locomotor behavior

abnormal neuroanatomy

abnormal neuroanatomy, with Scer\GAL4^ey-OK107

ey^UAS.cHa

abnormal neuroanatomy (with Df(4)J2)

abnormal neuroanatomy (with ey^D1Da)

ey^J5.71

abnormal neuroanatomy (with ey^J5.71)

abnormal neuroanatomy (with ey^JD)

ey^J5.71

abnormal size | adult stage, with Scer\GAL4^ey.PU

ey^UAS.cHa

decreased body size (with ey^D1Da)

ey^JD

decreased body size (with ey^JD)

ey^D1Da

decreased cell size (with ey^D1Da)

ey^JD

decreased cell size (with ey^JD)

ey^D1Da

hyperplasia | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

increased cell death

ey²

increased cell death | larval stage

ey^D

increased cell growth rate | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

ey^GD1440

some die during embryonic stage, with Scer\GAL4^hs.PB

ey^UAS.cHa

some die during larval stage, with Scer\GAL4^ey-OK107

ey^UAS.cHa

some die during pupal stage

some die during pupal stage | recessive

visible

visible, with Scer\GAL4^30A

visible, with Scer\GAL4^ap-md544

visible, with Scer\GAL4^Bx-MS1096

ey^UAS.cHa

visible, with Scer\GAL4^dpp.blk1

visible, with Scer\GAL4^dpp.PU

visible, with Scer\GAL4^ey.PH

visible, with Scer\GAL4^lz-gal4

ey^UAS.cHa

visible, with Scer\GAL4^MS941

ey^UAS.cHa

visible, with Scer\GAL4^p339

ey^UAS.cHa

visible, with Scer\GAL4^unspecified

ey^UAS.cHa

visible, with Scer\GAL4^upd1-E132

ey^UAS.cHa

visible (with Df(4)J2)

visible (with ey²)

ey^OK107-16

visible (with ey^D1Da)

visible (with ey^EH)

ey^OK107-16

visible (with ey^J5.71)

visible (with ey^JD)

visible (with ey^OK107-4)

visible (with ey^OK107-6)

visible (with ey^OK107-10)

visible (with ey^OK107-16)

visible (with ey^R)

visible | adult stage, with Scer\GAL4^bi.PU

ey^UAS.cUa

visible | adult stage, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

visible | adult stage, with Scer\GAL4^ey.PU

ey^UAS.cHa

visible | female limited, with Scer\GAL4^Bx-MS1096

ey^{UAS.ORF.GW.Tag:HA}

visible | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

ey^{UAS.ORF.GW.Tag:HA}

visible | heat sensitive

ey¹

visible | male limited, with Scer\GAL4^Bx-MS1096

ey^KK107100

visible | recessive

Phenotype manifest in

Allele

adult brain

adult central complex

adult central complex (with Df(4)J2)

adult central complex (with ey^D1Da)

adult central complex (with ey^EH)

ey^OK107-16

adult central complex (with ey^J5.71)

adult central complex (with ey^JD)

adult central complex (with ey^OK107-4)

adult central complex (with ey^OK107-6)

adult central complex (with ey^OK107-10)

adult central complex (with ey^OK107-16)

adult head

ey^D

adult head bristle | ectopic, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

adult median bundle (with ey^D1Da)

ey^JD

adult median bundle (with ey^JD)

ey^D1Da

adult subretinal glial cell

adult mushroom body, with Scer\GAL4^ey-OK107

ey^UAS.cHa

adult mushroom body (with Df(4)J2)

adult mushroom body (with ey^D1Da)

adult mushroom body (with ey^EH)

ey^OK107-16

adult mushroom body (with ey^J5.71)

adult mushroom body (with ey^JD)

adult mushroom body (with ey^OK107-4)

adult mushroom body (with ey^OK107-6)

adult mushroom body (with ey^OK107-10)

adult mushroom body (with ey^OK107-16)

adult optic lobe

adult optic lobe | pupal stage | somatic clone, with Scer\GAL4^ey-OK107

ey^{1-545.enRD.UAS.Tag:MYC}

adult pars intercerebralis (with ey^D1Da)

ey^JD

adult pars intercerebralis (with ey^JD)

ey^D1Da

ey¹

antenna

antenna, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

antenna, with Scer\GAL4^dpp.PU

antenna, with Scer\GAL4^upd1-E132

ey^UAS.cHa

antenna & eye | ectopic, with Scer\GAL4^upd1-E132

ey^UAS.cHa

antenna | ectopic, with Scer\GAL4^ey.PH, ey²

ey^ΔHD.UAS

antenna | ectopic, with Scer\GAL4^ey.PH, ey^ΔHD.UAS

ey²

antenna | proximal, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

antennal disc & eye | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

anterior-posterior compartment boundary of the wing disc | somatic clone, with Scer\GAL4^30A

ey^UAS.cHa

anterior-posterior compartment boundary of the wing disc | somatic clone, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

anterior-posterior compartment boundary of the wing disc | somatic clone, with Scer\GAL4^ap-md544

ey^UAS.cHa

anterior-posterior compartment boundary of the wing disc | somatic clone, with Scer\GAL4^bi-omb-Gal4

ey^UAS.cHa

arista

ey^JD

calyx of adult mushroom body

cell body rind of adult medulla

ey^D1Da

ellipsoid body

ellipsoid body, with Scer\GAL4^ey-OK107

ey^{1-545.enRD.UAS.Tag:MYC}

embryonic/larval hemolymph | late third instar larval stage

ey^JD

embryonic/larval optic lobe | somatic clone, with Scer\GAL4^ey-OK107

ey^{1-545.enRD.UAS.Tag:MYC}

embryonic brain, with Scer\GAL4^sca-537.4

ey^UAS.cHa

embryonic central brain neuron, with Scer\GAL4^sca-537.4

ey^UAS.cHa

eye

eye, with Scer\GAL4^dpp.blk1, ey²

ey^ΔPD.UAS

eye, with Scer\GAL4^dpp.blk1, ey^ΔPD.UAS

ey²

eye, with Scer\GAL4^ey.PH

eye, with Scer\GAL4^ey.PH, ey²

ey^ΔHD.UAS

eye, with Scer\GAL4^ey.PH, ey^ΔHD.UAS

ey²

eye, with Scer\GAL4^ey.PU

ey^UAS.cHa

eye, with Scer\GAL4^unspecified

ey^UAS.cHa

eye (with Df(4)BA)

ey^JD

eye (with Df(4)J2)

eye (with ey²)

eye (with ey^D1Da)

eye (with ey^D)

eye (with ey^EH)

ey^OK107-16

eye (with ey^J5.71)

eye (with ey^JD)

eye (with ey^OK107-4)

eye (with ey^OK107-6)

eye (with ey^OK107-10)

eye (with ey^OK107-16)

eye (with ey^R)

eye | ectopic, with Scer\GAL4^30A

eye | ectopic, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

eye | ectopic, with Scer\GAL4^ap-md544

eye | ectopic, with Scer\GAL4^bi.PU

ey^UAS.cUa

eye | ectopic, with Scer\GAL4^Bx-MS1096

ey^UAS.cHa

eye | ectopic, with Scer\GAL4^dpp.blk1

eye | ectopic, with Scer\GAL4^dpp.blk1, ey²

ey^ΔHD.UAS

eye | ectopic, with Scer\GAL4^dpp.blk1, ey^J5.71

ey^ΔHD.UAS

eye | ectopic, with Scer\GAL4^dpp.blk1, ey^ΔHD.UAS

eye | ectopic, with Scer\GAL4^dpp.PU

eye | ectopic, with Scer\GAL4^MS941

ey^UAS.cHa

eye | ectopic, with Scer\GAL4^upd1-E132

ey^UAS.cHa

eye | ectopic | heat sensitive

ey^hs.PH

eye | ectopic | somatic clone, with Scer\GAL4^30A

ey^UAS.cHa

eye | ectopic | somatic clone, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

eye | ectopic | somatic clone, with Scer\GAL4^ap-md544

ey^UAS.cHa

eye | ectopic | somatic clone, with Scer\GAL4^bi-omb-Gal4

ey^UAS.cHa

eye | heat sensitive

ey¹

eye | pharate adult stage, with Scer\GAL4^dpp.blk1

ey^ΔPAI.UAS

eye-antennal disc

eye-antennal disc | larval stage, with Scer\GAL4^bi.PU

ey^UAS.cUa

eye disc | ectopic | larval stage, with Scer\GAL4^bi.PU

ey^UAS.cUa

eye photoreceptor cell & dorsal mesothoracic disc | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

eye photoreceptor cell & ventral thoracic disc | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

eye photoreceptor cell | ectopic & antennal disc, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

fan-shaped body

gena

ey⁴⁶

glial cell, with Scer\GAL4^sca-537.4

ey^UAS.cHa

haltere, with Scer\GAL4^ap-md544

haltere, with Scer\GAL4^dpp.PU

ey^UAS.cWa

haltere, with Scer\GAL4^upd1-E132

ey^UAS.cHa

haltere & eye | ectopic, with Scer\GAL4^upd1-E132

ey^UAS.cHa

haltere & ommatidium | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

haltere | proximal, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

haltere disc, with Scer\GAL4^30A

ey^UAS.cHa

head

lobe system of adult mushroom body

ey^R

Kenyon cell, with Scer\GAL4^238Y

ey^UAS.cHa

lamina

ey^D1Da

lamina anlage glial cell

ey¹

larval intersegmental nerve, with Scer\GAL4^sca-537.4

ey^UAS.cHa

larval longitudinal connective, with Scer\GAL4^sca-537.4

ey^UAS.cHa

larval segmental nerve, with Scer\GAL4^sca-537.4

ey^UAS.cHa

larval ventral nerve cord, with Scer\GAL4^sca-537.4

ey^UAS.cHa

lateral cervical tract, with Scer\GAL4^sca-537.4

ey^UAS.cHa

leg, with Scer\GAL4^dpp.blk1

leg, with Scer\GAL4^dpp.PU

leg, with Scer\GAL4^upd1-E132

ey^UAS.cHa

leg & eye | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

leg & eye | ectopic, with Scer\GAL4^upd1-E132

ey^UAS.cHa

leg disc, with Scer\GAL4^hs.2sev

ey^UAS.cHa

lobula

ey^D1Da

lobula plate

ey^D1Da

maxillary palp

ey^JD

medulla

ey^D1Da

medulla | somatic clone, with Scer\GAL4^ey-OK107

ey^{1-545.enRD.UAS.Tag:MYC}

medulla serpentine layer

ey^D1Da

mushroom body & neuron

mushroom body medial lobe

mushroom body vertical lobe, with Scer\GAL4^238Y

ey^UAS.cHa

mushroom body vertical lobe, with Scer\GAL4^hs.PB

ey^UAS.cHa

neurite (with ey^D1Da)

ey^JD

neurite (with ey^JD)

ey^D1Da

neuron | ectopic, with Scer\GAL4^30A

ey^UAS.cHa

neuropil & mushroom body & pupa

ey^unspecified

ommatidium

ey²

ommatidium, with Scer\GAL4^ey.PH

ey^UAS.cHa

ommatidium, with Scer\GAL4^lz-gal4

ey^UAS.cHa

ommatidium | ectopic, with Scer\GAL4^ap-md544

ey^UAS.cHa

ommatidium | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

photoreceptor | ectopic | somatic clone, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

photoreceptor | ectopic | third instar larval stage, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

photoreceptor neuron

ey¹

proboscis & ommatidium | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

protocerebral bridge

ey^D1Da

retina

ey²

retina | ectopic, with Scer\GAL4^30A

ey^UAS.cHa

rhabdomere, with Scer\GAL4^lz-gal4

ey^UAS.cHa

symmetrical commissure, with Scer\GAL4^sca-537.4

ey^UAS.cHa

third segment of antenna

ey^JD

tibia, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

tritocerebral commissure, with Scer\GAL4^sca-537.4

ey^UAS.cHa

ventral thoracic disc & eye | ectopic, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

vertical bristle 1

ey⁴⁶

vertical bristle 2

ey⁴⁶

vertical lobe of adult mushroom body, with Scer\GAL4^238Y

ey^UAS.cHa

vertical lobe of adult mushroom body, with Scer\GAL4^ey-OK107

ey^UAS.cHa

vertical lobe of adult mushroom body, with Scer\GAL4^hs.PB

ey^UAS.cHa

vibrissal bristle

ey⁴⁶

wing, with Scer\GAL4^30A

ey^UAS.cHa

wing, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

wing, with Scer\GAL4^ap-md544

wing, with Scer\GAL4^Bx-MS1096

ey^UAS.cHa

wing, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

wing, with Scer\GAL4^dpp.PU

wing, with Scer\GAL4^MS941

ey^UAS.cHa

wing, with Scer\GAL4^p339

ey^UAS.cHa

wing, with Scer\GAL4^upd1-E132

ey^UAS.cHa

wing (with ey^D1Da)

ey^JD

wing (with ey^JD)

ey^D1Da

wing & eye | ectopic, with Scer\GAL4^MS941

ey^UAS.cHa

wing & eye | ectopic, with Scer\GAL4^upd1-E132

ey^UAS.cHa

wing | female limited, with Scer\GAL4^Bx-MS1096

ey^{UAS.ORF.GW.Tag:HA}

wing | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

ey^{UAS.ORF.GW.Tag:HA}

wing | male limited, with Scer\GAL4^Bx-MS1096

ey^KK107100

wing | proximal, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

wing disc, with Scer\GAL4^30A

ey^UAS.cHa

wing disc, with Scer\GAL4^ap-md544

ey^UAS.cHa

wing disc, with Scer\GAL4^dpp.blk1

ey^ΔPAI.UAS

wing disc, with Scer\GAL4^hs.2sev

ey^UAS.cHa

wing disc | larval stage, with Scer\GAL4^bi.PU

ey^UAS.cUa

wing disc | posterior | somatic clone, with Scer\GAL4^30A

ey^UAS.cHa

wing disc | posterior | somatic clone, with Scer\GAL4^Act5C.PI

ey^UAS.cHa

wing disc | posterior | somatic clone, with Scer\GAL4^ap-md544

ey^UAS.cHa

wing disc | posterior | somatic clone, with Scer\GAL4^bi-omb-Gal4

ey^UAS.cHa

wing disc | somatic clone | third instar larval stage, with Scer\GAL4^Act5C.PI

wing disc | third instar larval stage, with Scer\GAL4^Bx-MS1096

ey^UAS.cHa

wing hinge, with Scer\GAL4^30A

wing hinge, with Scer\GAL4^Bx-MS1096

ey^UAS.cHa

wing hinge, with Scer\GAL4^dpp.blk1

ey^UAS.cHa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (154)

Hsap\PAX6

5 of 14

Yes

Hsap\MIXL1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DUXB

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Hsap\LOC112268164

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (122)

Rnor\Pax4

4 of 14

Yes

Rnor\Pax6

4 of 14

Yes

Rnor\Mixl1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Hoxa2

1 of 14

Rnor\Hoxa3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rhox3

1 of 14

Yes

Rnor\Rhox4g

1 of 14

Yes

Rnor\Rhox8

1 of 14

Rnor\Rhox9

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (156)

Mmus\Pax4

4 of 14

Yes

Mmus\Pax6

4 of 14

Yes

Mmus\Mixl1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Gsx1

1 of 14

Mmus\Gsx2

1 of 14

Mmus\Hesx1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rhox2b

1 of 14

Yes

Mmus\Rhox2c

1 of 14

Yes

Mmus\Rhox2d

1 of 14

Yes

Mmus\Rhox2e

1 of 14

Yes

Mmus\Rhox2f

1 of 14

Yes

Mmus\Rhox2g

1 of 14

Yes

Mmus\Rhox2h

1 of 14

Yes

Mmus\Rhox3a2

1 of 14

Yes

Mmus\Rhox3a

1 of 14

Yes

Mmus\Rhox3c

1 of 14

Yes

Mmus\Rhox3e

1 of 14

Yes

Mmus\Rhox3f

1 of 14

Yes

Mmus\Rhox3g

1 of 14

Yes

Mmus\Rhox3h

1 of 14

Yes

Mmus\Rhox4a2

1 of 14

Yes

Mmus\Rhox4a

1 of 14

Yes

Mmus\Rhox4b

1 of 14

Yes

Mmus\Rhox4c

1 of 14

Yes

Mmus\Rhox4d

1 of 14

Yes

Mmus\Rhox4e

1 of 14

Yes

Mmus\Rhox4f

1 of 14

Yes

Mmus\Rhox4g

1 of 14

Yes

Mmus\Rhox6

1 of 14

Yes

Mmus\Rhox7a

1 of 14

Yes

Mmus\Rhox7b

1 of 14

Yes

Mmus\Rhox8

1 of 14

Yes

Mmus\Rhox9

1 of 14

Yes

Mmus\Rhox10

1 of 14

Mmus\Rhox11

1 of 14

Mmus\Rhox12

1 of 14

Yes

Mmus\Sdcbp

1 of 14

Mmus\Sebox

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (132)

Xtro\LOC100485335

3 of 13

Yes

Xtro\pax6

3 of 13

Yes

Xtro\crx

2 of 13

Xtro\drgx

2 of 13

Xtro\gsc2

2 of 13

Yes

Xtro\homeobox100496651-provisional

2 of 13

Yes

Xtro\nobox

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\hoxc13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\med9

1 of 13

Xtro\meox2

1 of 13

Xtro\mix1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (163)

Drer\pax4

5 of 14

Yes

Drer\pax6b

5 of 14

Yes

Drer\pax6a

4 of 14

Drer\mixl1

3 of 14

Yes

Drer\mxtx1

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\shox2

2 of 14

Drer\shox

2 of 14

Drer\zgc:101100

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\hoxa13b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (58)

Cele\vab-3

5 of 14

Yes

Cele\ceh-53

4 of 14

Yes

Cele\egl-38

3 of 14

Cele\eyg-1

3 of 14

Cele\npax-1

3 of 14

Yes

Cele\npax-2

3 of 14

Cele\npax-3

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (67)

Agam\AgaP_AGAP000063

7 of 12

Yes

Agam\AgaP_AGAP000067

7 of 12

Yes

5 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP005027

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009630

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (45)

Atha\ANL2

2 of 13

Yes

Atha\FWA

2 of 13

Yes

Atha\HB-1

2 of 13

Yes

Atha\HB-3

2 of 13

Yes

Atha\HB20

2 of 13

Yes

Atha\HB21

2 of 13

Yes

Atha\HB40

2 of 13

Yes

Atha\HB53

2 of 13

Yes

Atha\HDG1

2 of 13

Yes

Atha\HDG7

2 of 13

Yes

Atha\RLT2

2 of 13

Yes

Atha\ATHB13

1 of 13

Atha\ATHB-15

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\PHO2

3 of 13

Yes

Scer\YHP1

1 of 13

Scer\YOX1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\phx1

4 of 12

Yes

Spom\yox1

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:ey. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (75)

MIXL1; Mix paired-like homeobox

6 of 13

gsb

6 of 13

gsb-n

6 of 13

prd

6 of 13

toe

6 of 13

5 of 13

toy

5 of 13

4 of 13

CG9876

4 of 13

CG11294

4 of 13

CG32532

4 of 13

Gsc

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

hbn

3 of 13

otp

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

B-H1

2 of 13

B-H2

2 of 13

CG34367

2 of 13

eve

2 of 13

HGTX

2 of 13

lms

2 of 13

OdsH

2 of 13

scro

2 of 13

tin

2 of 13

abd-A

1 of 13

Abd-B

1 of 13

Antp

1 of 13

Awh

1 of 13

bap

1 of 13

bsh

1 of 13

btn

1 of 13

C15

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Dbx

1 of 13

Dfd

1 of 13

Dll

1 of 13

ems

1 of 13

exex

1 of 13

ftz

1 of 13

H2.0

1 of 13

HHEX

1 of 13

ind

1 of 13

inv

1 of 13

lbe

1 of 13

Lim1

1 of 13

Lim3

1 of 13

NK7.1

1 of 13

nub

1 of 13

Scr

1 of 13

slou

1 of 13

Ubx

1 of 13

unpg

1 of 13

vnd

1 of 13

zen2

1 of 13

zen

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 8 )

Human Ortholog

Disease

Evidence

References

PAX6; paired box 6

model of autosomal dominant keratitis

IEA

(FlyBase, 2019-)

model of Peters anomaly

IEA

(FlyBase, 2019-)

model of anterior segment dysgenesis 5

IEA

(FlyBase, 2019-)

model of coloboma of optic nerve

IEA

(FlyBase, 2019-)

model of bilateral optic nerve hypoplasia

IEA

(FlyBase, 2019-)

model of foveal hypoplasia 1

IEA

(FlyBase, 2019-)

model of coloboma

IEA

(FlyBase, 2019-)

model of aniridia 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PAX6; paired box 6

5 of 14

607108

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

LEUKEMIA, ACUTE LYMPHOBLASTIC, SUSCEPTIBILITY TO, 3; ALL3

PAX7; paired box 7

3 of 14

167410

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

(Tanaka-Matakatsu et al., 2015)

ey - AOX1

(Hu et al., 2017.6.13)

ey - Bro

(Hu et al., 2017.6.13)

ey - CG30324

(Hu et al., 2017.6.13)

ey - CG42688

(Hu et al., 2017.6.13)

ey - CG5011

(Hu et al., 2017.6.13)

ey - CG6023

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Hu et al., 2017.6.13)

ey - CG6654

two hybrid array

(Shokri et al., 2019)

ey - CtBP

(Hoang et al., 2010)

ey - Hipk

enzymatic study, autoradiography

(Steinmetz et al., 2018)

ey - Hr51

two hybrid array

(Shokri et al., 2019)

ey - Hr78

two hybrid array

(Shokri et al., 2019)

ey - Mst87F

(Hu et al., 2017.6.13)

ey - Nanp

(Hu et al., 2017.6.13)

ey - Poxm

bimolecular fluorescence complementation, fluorescence microscopy

(Hu et al., 2017.6.13)

ey - Ubx

(Bischof et al., 2018)

ey - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

ey - cdm

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

ey - da

coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, pull down, western blot

(Tanaka-Matakatsu et al., 2014)

ey - dac

(Okamoto and Nishimura, 2015, Okamoto et al., 2012)

ey - dan

anti bait coimmunoprecipitation, western blot, pull down, autoradiography, two hybrid, anti tag coimmunoprecipitation

(Hoang et al., 2010, Curtiss et al., 2007)

ey - danr

two hybrid, pull down, autoradiography

(Curtiss et al., 2007)

ey - disco

(Hu et al., 2017.6.13)

ey - dsx

(Hu et al., 2017.6.13)

ey - exd

anti tag coimmunoprecipitation, anti tag western blot

(Bessa et al., 2002)

ey - eya

(Jin and Mardon, 2016)

ey - foxo

coimmunoprecipitation, anti tag western blot

(Okamoto and Nishimura, 2015)

ey - gro

pull down, anti tag western blot, autoradiography, anti tag coimmunoprecipitation

(Choi et al., 2005)

ey - hth

(Bessa et al., 2002)

ey - so

(Zhang et al., 2006)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Antp

(Plaza et al., 2001)

suppressible

ato::da

(Tanaka-Matakatsu et al., 2014)

suppressible

brk

(Kango-Singh et al., 2003)

enhanceable

(Kango-Singh et al., 2003)

suppressible

(Wang and Sun, 2012)

suppressible

CtBP

(Hoang et al., 2010)

enhanceable

(Tanaka-Matakatsu et al., 2014)

enhanceable

dac

(Martini et al., 2000, Chen et al., 1999)

enhanceable

dpp

(Nfonsam et al., 2012, Chen et al., 1999)

ey|hh

enhanceable

dpp

(Kango-Singh et al., 2003)

enhanceable

eya

(Chen et al., 1999, Bonini et al., 1997)

suppressible

eya

(Bonini et al., 1997)

enhanceable

(Jang et al., 2003)

suppressible

(Jang et al., 2003)

enhanceable

gish

(Hummel et al., 2002)

enhanceable

(Nfonsam et al., 2012)

suppressible

(Kango-Singh et al., 2003)

suppressible

hth

(Wang and Sun, 2012)

suppressible

Mpe

(Hughes and Shelton, 1980)

enhanceable

(Nfonsam et al., 2012)

suppressible

Nf-YA

(Yoshioka et al., 2007)

enhanceable

Opt

(Postlethwait, 1974)

suppressible

(Benassayag et al., 2003)

suppressible

shg

(Morante et al., 2011)

enhanceable

(Pignoni, 2001.1.26)

ey|eya|dpp

enhanceable

(Pappu et al., 2003)

enhanceable

tkv

(Niwa et al., 2004)

suppressible

toy

(Jacobsson et al., 2009, Punzo et al., 2002)

suppressible

(Niwa et al., 2004)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Antp

suppressible

(Plaza et al., 2008, Plaza et al., 2001)

CtBP

suppressible

(Hoang et al., 2010)

dac

enhanceable

(Martini et al., 2000)

dpp

enhanceable

(Curtiss and Mlodzik, 2000)

enhanceable

(Jang et al., 2003)