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General Information
Symbol
Dmel\sv
Species
D. melanogaster
Name
shaven
Annotation Symbol
CG11049
Feature Type
FlyBase ID
FBgn0005561
Gene Model Status
Stock Availability
Gene Snapshot
shaven (sv) encodes a transcription factor and a member of the paired box family of genes. It is primarily involved in the terminal differentiation of specific cell types during the development of a variety of sensory organs, including the bristles and the eye. [Date last reviewed: 2019-03-14]
Also Known As
D-Pax2, spa, sparkling, Pax2, dPax2
Key Links
Genomic Location
Cytogenetic map
Sequence location
4:1,088,798..1,113,317 [+]
Recombination map
4-0
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
PAIRED DOMAIN TRANSCRIPTION FACTORS -
The paired domain transcription factors are sequence-specific DNA binding proteins that regulate transcription. These members have the characteristic paired domain but lack the homeodomain. (Adapted from FBrf0232555 and FBrf0135231).
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
spa: sparkling
Eyes rough in varying degrees and somewhat bulging. Affected by genetic modifiers. More extreme at 17-19 than at 22-25. Heterochromatin and sex affect expression so that X/0 > X/X > X/Y > X/X/Y; also enhanced by Df(2R)M41A10; spa haplo-4s have an exaggerated phenotype. RK2.
spaA
Dominant rough-eye allele; more extreme than spaCat. spaA/spapol shows extreme poliert phenotype; spaA/spaCat lethal. RK1A.
spaCat: sparkling-Cataract
Posterior third or half of eye of heterozygote rough; facets irregular and fused. Homozygous lethal. Stocks vary in expression, presumably because of genetic modifiers. X/X and X/0 flies that are spaCat/spa show the bulging eyes and roughening of spa and the posterior fused facets of spaCat; X/X/Y and X/Y flies have only the spaCat phenotype. spaCat/spapol has fusion of facets over entire surface of eye and roughness in posterior region of eye. spaCat/4-sim is wild type. spaCat/+ more extreme than spaCat/+/+ (Davis, 1969, Genetics 61: 577-94). RK2.
spae(lz): sparkling-enhancer of lozenge
Homozygote wild type in absence of lz; eyes strongly roughened in presence of heterozygous lz3, lz34, lz36, or lzD. Slight eye roughening when both spae(lz) and a lz allele are heterozygous. spae(lz)/spapol and spae(lz)/spap65 have very rough eyes but normal tarsal claws and spermathecae. RK3.
spap61: sparkling-poliert type
Eyes small, rough, and glazed. More extreme than spapol or spap65. Nonpigmented tarsal claws. RK1.
spap65
Eyes somewhat reduced in size, rough and partially glazed. More extreme than spapol but less so than spap61. Tarsal claws unpigmented and possibly reduced; reminiscent of certain lozenge mutants. Pulvilli and accessory female reproductive structures appear normal. Heterozygote with spapol and spap61 has affected tarsal claws as well as rough eyes. Heterozygote with spa has slightly roughened eyes at 25 but markedly roughened eyes at 18; female somewhat more extreme than male. Viability and fertility good. RK1.
spapol: sparkling-poliert
Eyes rather small; surface smooth and glassy. During second day of pupal life, retinula cells withdraw from other cells of eye disk. SEM studies show irregular disposition and morphology of ommatidial hairs as well as numerous necrotic pits over surface of eye [Oster and Crang, 1972, Trans. Am. Microsc. Soc. 91: 600-02 (fig.); Strum-Tegethoff and Dicke, 1974, Theor. Appl. Genet. 44: 762-65]. ERG absent [Grossfield, Handbook of Genetics (King, ed.). Plenum, New York, pp. 679-702]. spapol/spaCat has extreme phenotype; spapol/spa slightly more extreme than spa (Sturtevant, 1961, DIS 35: 47). Homozygote has excellent viability and fertility. RK1.
*sv: shaven
Bristles reduced, somewhat variably. Trichogen irregularly displaced and usually partly converted to socket (Lees and Waddington, 1942, DIS 16: 70). sv/sv/sv triplo-4 nearly normal. sv haplo-4 extreme shaven (Schultz, 1935, Am. Naturalist 69: 30-54). Expression depends on temperature: excellent at 19, overlaps wild type at 25, and entirely wild type at 30. RK2.
sv35a
Resembles svn more than sv. Bristles frequently reduced to stumps. RK2.
svde: shaven-depilate
thumb
svde: shaven-depilate
Edith M. Wallace, unpublished.
More extreme than svn. Thorax denuded over large areas. Phenotype more severe than H2; bristleless sockets found on adult integumentary derivatives of all imaginal discs; nearly 100% penetrance on thorax. Shafts, where present, often bent, twisted, or forked; up to 97% of bristle organs on wing costa and distal leg segments fail to produce normal shafts. Bracts present when bristle normally formed; otherwise bracts missing (Tobler, Rothenbuhler, and Nothiger, 1973, Experientia 29: 370-71). Both sexes sterile. RK2.
svn: shaven-naked
Extremely short bristles. Viability excellent. Trichogen irregularly displaced, becoming more or less converted into tormogen [Lees and Waddington, 1943, Proc. Roy. Soc. (London), Ser. B, 131: 87-110 (fig.)]. Polarity of microchaetae in vicinity of double sockets disrupted such that they form a whorl around socket [Toney and Thompson, 1980, Experientia 36: 644-45 (fig.)]. In triplo-4 svn/svn/svn, the phenotype is more nearly normal than in diplo-4. RK1.
Summary (Interactive Fly)
paired domain and homeodomain (partial) - Pax2, 5 and 8 homolog - Denticle formation requires transcription of , which is under positive regulation by the Egfr pathway and negative regulation by the Wingless pathway
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
7

Please see the GBrowse view of Dmel\sv or the JBrowse view of Dmel\sv for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089327
4693
844
FBtr0089328
4102
647
FBtr0100342
4201
680
FBtr0100344
2749
792
FBtr0100345
2257
628
FBtr0100346
4501
842
FBtr0301563
3721
491
Additional Transcript Data and Comments
Reported size (kB)
4.672 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088366
90.8
844
6.45
FBpp0088367
69.5
647
6.74
FBpp0099747
73.1
680
6.71
FBpp0099749
85.4
792
6.47
FBpp0099750
67.7
628
6.74
FBpp0099751
90.6
842
6.45
FBpp0290778
52.4
491
7.10
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sv using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
At embryonic stages 9-10, sv is expressed in the procephalic and ventral neurogenic regions in a segmentally repeated pattern. The anterior-most expression domain is at the future deuterocerebral/triterocerebral boundary. By embryonic stage 14, sv is prominently expressed in a longitudinal stripe in the medial protocerebrum and in a transverse stripe at the posterior border of the deuterocerebrum. sv is also expressed in the hypopharyngeal sense organ primordium. sv is expressed near Poxn, but never in the same cell.
sv is expressed in a segmentally repeated pattern in the CNS and PNS in embryos. In larvae, expression was studied in imaginal discs and in the CNS. sv transcripts are expressed in the posterior portion of the eye disc. The anterior boundary of expression lags behind the morphogenetic furrow. Strong expression is also observed in isolated cells of the antennal, leg and wing discs. In the CNS, expression is strongest in the thoracic ventral ganglion and in the brain.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
sv protein is detected in eye imaginal discs. The anterior margin of sv expression occurs six to seven rows behind the morphogenetic furrow. It is expressed in all four cone cell precursors as they are added to the ommatidia. During early pupal stages, it is also expressed in primary pigment cell precursors at the time that they are recruited to the developing ommatidial clusters. It also appears in mechanosensory bristle cells.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
Expression Deduced from Reporters
Reporter: P{lacZ}svΔ122
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{spa-GAL4.J}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{sv-GFP.NLS.spa}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sv in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of sv
Transgenic constructs containing regulatory region of sv
Deletions and Duplications ( 39 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior dorsocentral bristle & tormogen cell
anterior dorsocentral bristle & trichogen cell
head bristle & tormogen cell, with Scer\GAL4Bx-MS1096
head bristle & tormogen cell | conditional ts, with Scer\GAL4hs.PB
head bristle & trichogen cell, with Scer\GAL4Bx-MS1096
head bristle & trichogen cell | conditional ts, with Scer\GAL4hs.PB
orbital bristle & trichogen cell | conditional ts, with Scer\GAL4hs.PB
posterior dorsocentral bristle & tormogen cell
scutum & macrochaeta
scutum & macrochaeta & tormogen cell
scutum & macrochaeta & tormogen cell | conditional ts, with Scer\GAL4hs.PB
scutum & macrochaeta & trichogen cell
scutum & macrochaeta & trichogen cell | conditional ts, with Scer\GAL4hs.PB
scutum & microchaeta
scutum & microchaeta & tormogen cell, with Scer\GAL4Bx-MS1096
scutum & microchaeta & trichogen cell
scutum & microchaeta & trichogen cell, with Scer\GAL4Bx-MS1096
scutum & microchaeta & trichogen cell | conditional ts, with Scer\GAL4hs.PB
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
Yes
8 of 15
No
Yes
7 of 15
No
Yes
2 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (9)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
Yes
7 of 15
No
Yes
 
6 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
Rattus norvegicus (Norway rat) (7)
7 of 13
Yes
Yes
6 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
7 of 12
Yes
Yes
4 of 12
No
Yes
4 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (16)
7 of 15
Yes
Yes
6 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
7 of 15
Yes
Yes
6 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903GR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501YA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09TG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HFF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0S4E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (10)
4 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
3 of 10
2 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Gene Group - Pathway Membership (FlyBase)
    External Data
    Linkouts
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    4
    Recombination map
    4-0
    Cytogenetic map
    Sequence location
    4:1,088,798..1,113,317 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    102F8-102F8
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    102F1-102F2
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Probably most distal visible locus on chromosome 4.
    Mapped in diplo-4 triploids.
    Stocks and Reagents
    Stocks (122)
    Genomic Clones (18)
    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: sv spa
          Source for merge of: sv Pax258
          Additional comments
          Source for merge of sv Pax258 was sequence comparison ( date:000202 ).
          Other Comments
          dsRNA has been made from templates generated with primers directed against this gene. RNAi of sv results in reduced arborization of ddaD and ddaE neurons, defects in muscle, alterations in the number of MD neurons and defects in dendrite morphogenesis.
          sv mutants results in a lack of sensory bristles, but has no phenotype in trichomes while sha mutants has no phenotype in bristles but results in a dramatic loss of denticles and trichomes. The sv and sha mutant phenotypes are thus distinct.
          sv is a high level transcriptional regulator of shaft cell differentiation and acts downstream of the N signaling pathway as a specific link between cell fate determination and cell differentiation in the bristle cell lineage.
          Flies carrying strong loss of function sv mutations specifically lack the shaft structures of the adult bristles.
          sv has been cloned and sequenced.
          sv is required for the proper specification and differentiation of cone and primary pigment cells in the eye.
          The mutation poliert, svspa-pol, is allelic to svspa-1.
          Origin and Etymology
          Discoverer
          Bridges, 14th Nov. 1920.
          Etymology
          Identification
          External Crossreferences and Linkouts ( 65 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          SignaLink - A signaling pathway resource with multi-layered regulatory networks.
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (33)
          Reported As
          Symbol Synonym
          Pax258
          l(4)40
          pax2/sparkling
          pol
          shaven/sparkling
          Secondary FlyBase IDs
          • FBgn0003468
          • FBgn0003649
          • FBgn0004541
          • FBgn0020913
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (211)