D-Pax2, spa, sparkling, Pax2, dPax2
paired domain and homeodomain (partial) - Pax2, 5 and 8 homolog - Denticle formation requires transcription of , which is under positive regulation by the Egfr pathway and negative regulation by the Wingless pathway
Please see the GBrowse view of Dmel\sv or the JBrowse view of Dmel\sv for information on other features
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Gene model reviewed during 5.47
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
4.672 (longest cDNA)
None of the polypeptides share 100% sequence identity.
844 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sv using the Feature Mapper tool.
Comment: reported as dorsal/lateral sensory complexes
At embryonic stages 9-10, sv is expressed in the procephalic and ventral neurogenic regions in a segmentally repeated pattern. The anterior-most expression domain is at the future deuterocerebral/triterocerebral boundary. By embryonic stage 14, sv is prominently expressed in a longitudinal stripe in the medial protocerebrum and in a transverse stripe at the posterior border of the deuterocerebrum. sv is also expressed in the hypopharyngeal sense organ primordium. sv is expressed near Poxn, but never in the same cell.
sv is expressed in a segmentally repeated pattern in the CNS and PNS in embryos. In larvae, expression was studied in imaginal discs and in the CNS. sv transcripts are expressed in the posterior portion of the eye disc. The anterior boundary of expression lags behind the morphogenetic furrow. Strong expression is also observed in isolated cells of the antennal, leg and wing discs. In the CNS, expression is strongest in the thoracic ventral ganglion and in the brain.
sv protein is detected in eye imaginal discs. The anterior margin of sv expression occurs six to seven rows behind the morphogenetic furrow. It is expressed in all four cone cell precursors as they are added to the ommatidia. During early pupal stages, it is also expressed in primary pigment cell precursors at the time that they are recruited to the developing ommatidial clusters. It also appears in mechanosensory bristle cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\sv in GBrowse 24-0
Probably most distal visible locus on chromosome 4.
Mapped in diplo-4 triploids.
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: sv spa
Source for merge of: sv Pax258
Source for merge of sv Pax258 was sequence comparison ( date:000202 ).
dsRNA has been made from templates generated with primers directed against this gene. RNAi of sv results in reduced arborization of ddaD and ddaE neurons, defects in muscle, alterations in the number of MD neurons and defects in dendrite morphogenesis.
Flies carrying strong loss of function sv mutations specifically lack the shaft structures of the adult bristles.
sv has been cloned and sequenced.
sv is required for the proper specification and differentiation of cone and primary pigment cells in the eye.
Bridges, 14th Nov. 1920.
