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Gene Dmel\sv

General Information
Symbol	Dmel\sv	Species	D. melanogaster
Name	shaven	Annotation symbol	CG11049
Feature type	protein_coding_gene	FlyBase ID	FBgn0005561
Gene Model Status	Current	Stock availability	102 publicly available
Also Known As	D-Pax2, spa, Pax2, Dpax2, Dpax-2, dPax258
Genomic Location
Chromosome (arm)	4	Recombination map
Cytogenetic map	102F8-102F8	Sequence location	4:1,109,444..1,133,943 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene shaven is referred to in FlyBase by the symbol Dmel\sv (CG11049, FBgn0005561). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific distal enhancer binding RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; regulation of R7 cell differentiation; dendrite morphogenesis; neuron development; regulation of retinal cone cell fate specification; muscle organ development. 54 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; adult segment; eo support cell; nervous system; rhabdomere R7; rhabdomere; imaginal precursor; antennal segment. It has 8 annotated transcripts and 8 annotated polypeptides. Protein features are: Homeodomain-like; Paired box protein, N-terminal; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1636090_a_at completely aligns to an exonic region of only a subset of 6 of the 8 FlyBase-annotated transcript isoforms of sv. Gene sequence location is 4:1109444..1133943.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	spa: sparkling Eyes rough in varying degrees and somewhat bulging. Affected by genetic modifiers. More extreme at 17-19 than at 22-25. Heterochromatin and sex affect expression so that X/0 > X/X > X/Y > X/X/Y; also enhanced by Df(2R)M41A10; spa haplo-4s have an exaggerated phenotype. RK2. spaA Dominant rough-eye allele; more extreme than spaCat. spaA/spapol shows extreme poliert phenotype; spaA/spaCat lethal. RK1A. spaCat: sparkling-Cataract Posterior third or half of eye of heterozygote rough; facets irregular and fused. Homozygous lethal. Stocks vary in expression, presumably because of genetic modifiers. X/X and X/0 flies that are spaCat/spa show the bulging eyes and roughening of spa and the posterior fused facets of spaCat; X/X/Y and X/Y flies have only the spaCat phenotype. spaCat/spapol has fusion of facets over entire surface of eye and roughness in posterior region of eye. spaCat/4-sim is wild type. spaCat/+ more extreme than spaCat/+/+ (Davis, 1969, Genetics 61: 577-94). RK2. spae(lz): sparkling-enhancer of lozenge Homozygote wild type in absence of lz; eyes strongly roughened in presence of heterozygous lz3, lz34, lz36, or lzD. Slight eye roughening when both spae(lz) and a lz allele are heterozygous. spae(lz)/spapol and spae(lz)/spap65 have very rough eyes but normal tarsal claws and spermathecae. RK3. spap61: sparkling-poliert type Eyes small, rough, and glazed. More extreme than spapol or spap65. Nonpigmented tarsal claws. RK1. spap65 Eyes somewhat reduced in size, rough and partially glazed. More extreme than spapol but less so than spap61. Tarsal claws unpigmented and possibly reduced; reminiscent of certain lozenge mutants. Pulvilli and accessory female reproductive structures appear normal. Heterozygote with spapol and spap61 has affected tarsal claws as well as rough eyes. Heterozygote with spa has slightly roughened eyes at 25 but markedly roughened eyes at 18; female somewhat more extreme than male. Viability and fertility good. RK1. spapol: sparkling-poliert Eyes rather small; surface smooth and glassy. During second day of pupal life, retinula cells withdraw from other cells of eye disk. SEM studies show irregular disposition and morphology of ommatidial hairs as well as numerous necrotic pits over surface of eye [Oster and Crang, 1972, Trans. Am. Microsc. Soc. 91: 600-02 (fig.); Strum-Tegethoff and Dicke, 1974, Theor. Appl. Genet. 44: 762-65]. ERG absent [Grossfield, Handbook of Genetics (King, ed.). Plenum, New York, pp. 679-702]. spapol/spaCat has extreme phenotype; spapol/spa slightly more extreme than spa (Sturtevant, 1961, DIS 35: 47). Homozygote has excellent viability and fertility. RK1. *sv: shaven Bristles reduced, somewhat variably. Trichogen irregularly displaced and usually partly converted to socket (Lees and Waddington, 1942, DIS 16: 70). sv/sv/sv triplo-4 nearly normal. sv haplo-4 extreme shaven (Schultz, 1935, Am. Naturalist 69: 30-54). Expression depends on temperature: excellent at 19, overlaps wild type at 25, and entirely wild type at 30. RK2. sv35a Resembles svn more than sv. Bristles frequently reduced to stumps. RK2. svde: shaven-depilate svde: shaven-depilate Edith M. Wallace, unpublished. More extreme than svn. Thorax denuded over large areas. Phenotype more severe than H2; bristleless sockets found on adult integumentary derivatives of all imaginal discs; nearly 100% penetrance on thorax. Shafts, where present, often bent, twisted, or forked; up to 97% of bristle organs on wing costa and distal leg segments fail to produce normal shafts. Bracts present when bristle normally formed; otherwise bracts missing (Tobler, Rothenbuhler, and Nothiger, 1973, Experientia 29: 370-71). Both sexes sterile. RK2. svn: shaven-naked Extremely short bristles. Viability excellent. Trichogen irregularly displaced, becoming more or less converted into tormogen [Lees and Waddington, 1943, Proc. Roy. Soc. (London), Ser. B, 131: 87-110 (fig.)]. Polarity of microchaetae in vicinity of double sockets disrupted such that they form a whorl around socket [Toney and Thompson, 1980, Experientia 36: 644-45 (fig.)]. In triplo-4 svn/svn/svn, the phenotype is more nearly normal than in diplo-4. RK1.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Transgenic Constructs P{UAS-sv.RNAi}
FB2012_01	Sequence features HFA17221 BKN22368 BKN45768 Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 102F8-102F8
Experimentally Determined Cytological Location
Cytogenetic map Notes References 102F1-102F2     (Fu, 1997.6.26)
Experimentally Determined Recombination Data
Location	4-3.0 (Sturtevant, 1951) 4- (Abrahamson et al., 1956, Bender, 1967)
Left of (cM)
Right of (cM)
Notes	Mapped in diplo-4 triploids. (Sturtevant, 1951) Probably most distal visible locus on chromosome 4. (Abrahamson et al., 1956)
Gene Model & Products
Please see the GBrowse view of Dmel\sv for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) sv-RA FBtr0089327  NM_079894   4673   844 sv-RC FBtr0089328  NM_166822   4082   647 sv-RD FBtr0100342  NM_001014701   4181   680 sv-RE FBtr0100343  NM_001014700   4690   794 sv-RF FBtr0100344  NM_001014699   2730   792 sv-RG FBtr0100345  NM_001014698   2238   628 sv-RH FBtr0100346  NM_001014697   4667   842 sv-RI FBtr0301563  NM_001169363   3859   491
Additional Transcript Data & Comments
Reported size (kB)	4.672 (longest cDNA) (Fu and Noll, 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein sv-PA   FBpp0088366   90.8   844   6.45     NP_524633   AAF59385 sv-PC   FBpp0088367   69.5   647   6.74     NP_726645   AAN06579 sv-PD   FBpp0099747   73.1   680   6.71     NP_001014701   AAX53596 sv-PE   FBpp0099748   86.0   794   6.47     NP_001014700   AAX53600 sv-PF   FBpp0099749   85.4   792   6.47     NP_001014699   AAX53598 sv-PG   FBpp0099750   67.7   628   6.74     NP_001014698   AAX53599 sv-PH   FBpp0099751   90.6   842   6.45     NP_001014697   AAX53597 sv-PI   FBpp0290778   52.4   491   7.10     NP_001162834   ACZ95103
Additional Polypeptide Data & Comments
Reported size (kDa)	844 (aa) (Fu and Noll, 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Paired box protein, N-terminal (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014135 AAF59385   AE014135 AAN06579   AE014135 AAX53596   AE014135 AAX53597   AE014135 AAX53598   AE014135 AAX53599   AE014135 AAX53600   AC010577   AC018481   AE014135 ACZ95103   AF010256 AAB86598   AF016888 AAB70249   BT022204   CO189395   CO189893   CO295465   CO305222   CO305431   CO308512   CO313833   CO316986   CO344174   EC065314   EC077230   EC077674   EC080816   EC088800   EC089312   EC215407   EC229763   EL875078   EL875079
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O16117 O16804 Q8IM96 Q59DN7 Q59DN9 Q59DN6 Q59DP0 Q59DN8 D1YSG9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval nervous system   (Fu and Noll, 1997) peripheral nervous system   (Fu and Noll, 1997) embryonic stage 10 -- 11   procephalic neurogenic region | segmentally repeated   (Hirth et al., 2003) ventral neurogenic region | segmentally repeated   (Hirth et al., 2003) embryonic stage 14   hypopharyngeal sense organ primordium   (Hirth et al., 2003) embryonic protocerebrum | medial & restricted   (Hirth et al., 2003) Comment:longitudinal stripe embryonic deuterocerebrum | posterior & restricted   (Hirth et al., 2003) Comment:transverse stripe at posterior border larval stage   morphogenetic furrow | posterior to   (Fu and Noll, 1997) eye disc   (Fu and Noll, 1997) embryonic/larval brain   (Fu and Noll, 1997) wing disc   (Fu and Noll, 1997) ventral thoracic disc   (Fu and Noll, 1997) antennal disc   (Fu and Noll, 1997) ventral nerve cord   (Fu and Noll, 1997)
Additional Descriptive Data
	sv is expressed in a segmentally repeated pattern in the CNS and PNS in embryos. In larvae, expression was studied in imaginal discs and in the CNS. sv transcripts are expressed in the posterior portion of the eye disc. The anterior boundary of expression lags behind the morphogenetic furrow. Strong expression is also observed in isolated cells of the antennal, leg and wing discs. In the CNS, expression is strongest in the thoracic ventral ganglion and in the brain. (Fu and Noll, 1997) At embryonic stages 9-10, sv is expressed in the procephalic and ventral neurogenic regions in a segmentally repeated pattern. The anterior-most expression domain is at the future deuterocerebral/triterocerebral boundary. By embryonic stage 14, sv is prominently expressed in a longitudinal stripe in the medial protocerebrum and in a transverse stripe at the posterior border of the deuterocerebrum. sv is also expressed in the hypopharyngeal sense organ primordium. sv is expressed near Poxn, but never in the same cell. (Hirth et al., 2003)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 10 -- 11   procephalic neurogenic region | segmentally repeated   (Hirth et al., 2003) ventral neurogenic region | segmentally repeated   (Hirth et al., 2003) embryonic stage 14   hypopharyngeal sense organ primordium   (Hirth et al., 2003) embryonic protocerebrum | medial & restricted   (Hirth et al., 2003) Comment:longitudinal stripe embryonic deuterocerebrum | posterior & restricted   (Hirth et al., 2003) Comment:transverse stripe at posterior border larval stage   cone cell | precursor   (Fu and Noll, 1997) eye disc   (Fu and Noll, 1997) pupal stage | early   primary pigment cell | precursor   (Fu and Noll, 1997) pupal stage   eye disc   (Fu and Noll, 1997) mechanosensory chaeta   (Fu and Noll, 1997)
Additional Descriptive Data
	sv protein is detected in eye imaginal discs. The anterior margin of sv expression occurs six to seven rows behind the morphogenetic furrow. It is expressed in all four cone cell precursors as they are added to the ommatidia. During early pupal stages, it is also expressed in primary pigment cell precursors at the time that they are recruited to the developing ommatidial clusters. It also appears in mechanosensory bristle cells. (Fu and Noll, 1997)
Marker for
Subcellular Localization
CV Term	nucleus (Fu and Noll, 1997)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0005561    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0005561 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0005561 expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr  (311) embryo 08-10hr  (464) embryo 10-12hr  (442) embryo 12-14hr  (569) embryo 14-16hr  (226) embryo 16-18hr  (216) embryo 18-20hr  (160) embryo 20-22hr  (111) embryo 22-24hr  (170) larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr  (167) white prepupae 24hr  (208) pupae 2d postWPP  (193) pupae 3d postWPP  (137) pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0005561 expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr  (311) embryo 08-10hr  (464) embryo 10-12hr  (442) embryo 12-14hr  (569) embryo 14-16hr  (226) embryo 16-18hr  (216) embryo 18-20hr  (160) embryo 20-22hr  111 embryo 22-24hr  (170) larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr  (167) white prepupae 24hr  (208) pupae 2d postWPP  (193) pupae 3d postWPP  137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    64 embryo 06-08hr    311 embryo 08-10hr    464 embryo 10-12hr    442 embryo 12-14hr    569 embryo 14-16hr    226 embryo 16-18hr    216 embryo 18-20hr    160 embryo 20-22hr    111 embryo 22-24hr    170 larva L1    83 larva L2    40 larva L3 12hr old    12 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    27 larva L3 puffstage 7-9    42 white prepupae new    59 white prepupae 12hr    167 white prepupae 24hr    208 pupae 2d postWPP    193 pupae 3d postWPP    137 pupae 4d postWPP    81 adult male 01day    97 adult male 05day    82 adult male 30day    82 adult female 01day    42 adult female 05day    30 adult female 30day    29 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0005561    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0005561 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0005561 expression level Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0005561 expression level Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    8.6 Larval Midgut    1.3 Larval Hindgut    3.2 Larval Malpighian Tubules    2.1 Larval Fat Body    8.4 Larval Salivary Gland    2.6 Larval Trachea    5.1 Larval Carcass    5.125 Adult Head    12.7 Adult Eye    38.55 Adult Brain    8.7 Adult Thoracic-Abdominal Ganglion    22.9 Adult Crop    4.5 Adult Midgut    7.8 Adult Hindgut    4.5 Adult Malpighian Tubules    3.9 Adult Fat Body    6.2 Adult Salivary Gland no informative data Adult Heart    3.45 Adult VirginFemale Spermatheca    2.2 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    2.8 Adult Male Accessory Gland    6.4 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    12.7   NA  Eye    38.55   NA  Brain    8.7   8.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    22.9   NA  Crop    4.5   1.3  Midgut    7.8   3.2  Hindgut    4.5   2.1  Malpighian Tubules    3.9   8.4  Fat Body    6.2   2.6  Salivary Gland    no informative data   NA  Heart    3.45   5.1  Trachea    NA   NA  VirginFemale Spermatheca    2.2   NA  InseminatedFemale Spermatheca    3.7   NA  Ovary    2.3   NA  Testis    2.8   NA  Male Accessory Gland    6.4   5.125  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005561 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11049-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal sv4-M1030 lethal | embryonic stage | recessive svI lethal | heat sensitive, with Scer\GAL4hs.PB svScer\UAS.cKa lethal | pharate adult stage, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa lethal | recessive sv6 sv7 sv8 svspa-Cat viable sv4G svrugoso-nu svspa-p65 viable, with Scer\GAL4pnr-MD237 svGD1545 Sterility Allele fertile svspa-p65 sterile svde sterile (with T(1;4)scH) svrugoso-nu Other Phenotypes Allele behavior defective | recessive svde increased cell death svspa-p65 svspa-pol short lived (with T(1;4)scH) svrugoso-nu uncoordinated svde visible svspa-p61 svspa-p65 svspa-pol visible, with Scer\GAL4ey.PH svScer\UAS.cJa svScer\UAS.cKa visible, with Scer\GAL4neur-GAL4-A101 svScer\UAS.cKa visible (with svn) svrugoso-nu visible (with svrugoso-nu) svn svspa-pol visible (with svspa-pol) svrugoso-nu visible (with T(1;4)scH) svrugoso-nu visible | dominant svspa-A svspa-Cat visible | dominant | cold sensitive svspa-Cat visible | recessive sv4G svde svn svspa-1 svspa-20 svspa-pol visible | somatic clone, with Scer\GAL4neur-GAL4-A101 svScer\UAS.cKa wild-type sv6.7.cFa sv+m1 sv+m2 sv+m4 sv+m6 sv+mFa Phenotype manifest in Allele adult head, with Scer\GAL4ey.PH svScer\UAS.cJa svScer\UAS.cKa antenna, with Scer\GAL4ey.PH svScer\UAS.cJa svScer\UAS.cKa anterior dorsocentral bristle & tormogen cell sv6 anterior dorsocentral bristle & trichogen cell sv6 svde chaeta, with Scer\GAL4neur-GAL4-A101 svScer\UAS.cKa chaeta (with svn) svrugoso-nu chaeta (with svrugoso-nu) svn chaeta (with T(1;4)scH) svrugoso-nu cone cell svspa-1 svspa-A svspa-pol cone cell | supernumerary, with Scer\GAL4sev.EP svScer\UAS.cKa external sensory organ | adult stage | somatic clone, with Scer\GAL4neur-GAL4-A101 svScer\UAS.cKa eye sv4G sv6 sv7 sv8 svspa-1 svspa-20 svspa-A svspa-Cat svspa-p61 svspa-p65 svspa-pol eye, with Scer\GAL4ey.PH svScer\UAS.cJa svScer\UAS.cKa eye | posterior svspa-A svspa-Cat eye disc svspa-p65 svspa-pol eye photoreceptor cell svspa-1 svspa-A svspa-pol head bristle & tormogen cell, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa head bristle & tormogen cell | conditional ts, with Scer\GAL4hs.PB svScer\UAS.cKa head bristle & trichogen cell, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa head bristle & trichogen cell | conditional ts, with Scer\GAL4hs.PB svScer\UAS.cKa interommatidial bristle svde svn svspa-1 svspa-20 svspa-pol lens sv6 sv7 sv8 svspa-1 svspa-pol lens | somatic clone svspa-pol macrochaeta sv1 sv35a sv6 sv7 sv8 svde svn svspa-20 macrochaeta, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa microchaeta svde svn svspa-20 ommatidium sv6 sv7 sv8 svspa-1 svspa-pol ommatidium (with svrugoso-nu) svspa-pol ommatidium (with svspa-pol) svrugoso-nu orbital bristle & trichogen cell | conditional ts, with Scer\GAL4hs.PB svScer\UAS.cKa pigment cell svspa-p65 svspa-pol posterior dorsocentral bristle & tormogen cell svde primary pigment cell svspa-A svspa-pol pseudocone svspa-1 svspa-pol retina svspa-p65 rhabdomere svspa-pol rhabdomere R7, with Scer\GAL4sev.EP svScer\UAS.cKa scutum & macrochaeta sv6 svde svn scutum & macrochaeta & tormogen cell sv7 svde scutum & macrochaeta & tormogen cell | conditional ts, with Scer\GAL4hs.PB svScer\UAS.cKa scutum & macrochaeta & trichogen cell sv6 sv7 sv8 svde svn scutum & macrochaeta & trichogen cell | conditional ts, with Scer\GAL4hs.PB svScer\UAS.cKa scutum & microchaeta sv6 svde svn scutum & microchaeta & tormogen cell, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa scutum & microchaeta & trichogen cell sv6 sv7 sv8 svn scutum & microchaeta & trichogen cell, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa scutum & microchaeta & trichogen cell | conditional ts, with Scer\GAL4hs.PB svScer\UAS.cKa thecogen cell sv6 tormogen cell | adult stage | somatic clone, with Scer\GAL4neur-GAL4-A101 svScer\UAS.cKa trichogen cell sv1 sv6 trichogen cell | adult stage | ectopic | somatic clone, with Scer\GAL4neur-GAL4-A101 svScer\UAS.cKa unguis svspa-p61 svspa-p65 wing, with Scer\GAL4Bx-MS1096 svScer\UAS.cKa
Classical Alleles ( 24 )
For All Classical Alleles Show
Allele of sv Class Mutagen Stocks Known lesion svspa-pol spontaneous 70 Yes svspa-Cat X ray 12 -- svn loss of function allele spontaneous 11 Yes svspa-1 spontaneous 2 Yes sv35a spontaneous 1 Yes svde loss of function allele spontaneous 1 Yes svMB03697 1 -- svspa-p65 spontaneous 1 -- sv+ 0 -- sv1 spontaneous 0 -- sv4-M1030 0 -- sv4G ethyl methanesulfonate 0 -- sv5 ethyl methanesulfonate 0 -- sv6 loss of function allele ethyl methanesulfonate 0 -- sv7 loss of function allele ethyl methanesulfonate 0 -- sv8 loss of function allele ethyl methanesulfonate 0 -- svI ethyl methanesulfonate 0 -- svrugoso-nu 0 -- svspa-20 ethyl methanesulfonate 0 Yes svspa-A X ray 0 Yes svspa-e(lz) spontaneous 0 -- svspa-p61 spontaneous 0 -- svunspecified 0 -- svΔ122 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of sv Class Mutagen Stocks Known lesion svJF02582 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes svKK102302 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes svScer\UAS.cJa FLPase 1 Yes sv+m1 in vitro construct - regulatory fusion 0 Yes sv+m2 in vitro construct - regulatory fusion 0 Yes sv+m4 in vitro construct - regulatory fusion 0 Yes sv+m6 in vitro construct - regulatory fusion 0 Yes sv+mFa in vitro construct - regulatory fusion 0 Yes sv2.0.cFa in vitro construct - regulatory fusion 0 Yes sv6.7.cFa in vitro construct - regulatory fusion 0 Yes svAct5C.PB in vitro construct - regulatory fusion 0 Yes svdsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes svGD1545 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes svhs.PF in vitro construct - regulatory fusion 0 Yes svm10 in vitro construct - regulatory fusion 0 Yes svm11 in vitro construct - regulatory fusion 0 Yes svm12 in vitro construct - regulatory fusion 0 Yes svm13 in vitro construct - regulatory fusion 0 Yes svm14 in vitro construct - regulatory fusion 0 Yes svm3 in vitro construct - regulatory fusion 0 Yes svm5 in vitro construct - regulatory fusion 0 Yes svm7 in vitro construct - regulatory fusion 0 Yes svm8 in vitro construct - regulatory fusion 0 Yes svm9 in vitro construct - regulatory fusion 0 Yes svmRDx3 in vitro construct - site directed mutagenesis 0 Yes svScer\FRT.Scer\UAS in vitro construct - regulatory fusion 0 Yes svScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes svScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes svsev.PB in vitro construct - regulatory fusion 0 Yes svsev.PJ in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Duplicated in	C(1;Y;4)d7 (Ahmad and Golic, 1998) Dp(1;4)193   Dp(4;3)f (Sousa-Neves, 1999.11.10, Matthews, 2002.1.16)
Disrupted in	Df(4)3 (Hochman, 1971, Hochman, 1974, Hochman, 1976) Df(4)11 (Hochman et al., 1964, Hochman, 1971, Hochman, 1974, Hochman, 1976) Df(4)12 (Hochman et al., 1964) Df(4)24 (Hochman et al., 1964) Df(4)40 (Hochman, 1971, Hochman, 1974, Hochman, 1976) Df(4)A6-2a (Sousa-Neves et al., 2005) Df(4)A6-2b (Sousa-Neves et al., 2005) Df(4)A6-4a (Sousa-Neves et al., 2005) Df(4)A6-4b (Sousa-Neves et al., 2005) Df(4)A6-5a (Sousa-Neves et al., 2005) Df(4)A6-5b (Sousa-Neves et al., 2005) Df(4)A6-5d (Sousa-Neves et al., 2005) Df(4)A6-7a (Sousa-Neves et al., 2005) Df(4)A6-7b (Sousa-Neves et al., 2005) Df(4)A6-9a (Sousa-Neves et al., 2005) Df(4)A6-10a (Sousa-Neves et al., 2005) Df(4)A6-11a (Sousa-Neves et al., 2005) Df(4)Cat (Hochman, 1971, Hochman, 1974, Hochman, 1976) Df(4)G (Kronhamn et al., 2002, Hochman et al., 1964, Hochman, 1971, Hochman, 1974, Hochman, 1976) Df(4)spa20 (Fu et al., 1998) Df(4)spa30 (Fu et al., 1998, Kronhamn et al., 2002) Df(4)spa47 (Fu et al., 1998, Kronhamn et al., 2002) Df(4)spa66 (Fu et al., 1998, Kronhamn et al., 2002) Df(4)spam18 (Kronhamn et al., 2002) Df(4)spam100 (Kronhamn et al., 2002) T(1;4)scH (Sousa-Neves, 1999.11.10, Sousa-Neves, 2000) T(2;4)X-12 (Cryderman et al., 1999) T(3;4)UbxA (Craymer, 1980, Fu and Noll, 1997)
Not disrupted in	Df(4)38 (Hochman, 1971, Hochman, 1974, Hochman, 1976) Df(4)BA (Kronhamn et al., 2002) Df(4)M101-1 (Hochman, 1971) Df(4)M101-4 (Hochman et al., 1964, Morgan, 1947)
Not duplicated in	Dp(1;Y)BS (Lindsley and Zimm, 1992) Dp(2;4)eyD (Hochman et al., 1964) Ts(2Lt;4Lt)b (Morgan, 1947)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{sv-lacZ.SME.mETS1,6} No P{sv-lacZ.SME.mETSx6} No P{sv-lacZ.SME.mRDx3} No P{sv-lacZ.SME.mSuHx8} No P{sv-lacZ.SME} No P{sv-lacZ.Y114} No UAS construct P{GD1545} NA P{KK102302} NA P{TRiP.JF02582} NA P{UAS(FRT.w+)sv.J} NA P{UAS(-FRT)sv.J} NA P{UAS-sv.B} NA P{UAS-sv.K} NA P{UAS-sv.RNAi} NA heat-shock construct P{hs-sv.F} NA characterization construct P{2.0-spa} NA P{2sev-sv.J} NA P{6.7-spa} NA P{sev-sv.B} NA P{spa+mFa} NA P{spa-GAL4.J} NA P{sv+m1} NA P{sv+m2} NA P{sv+m4} NA P{sv+m6} NA P{svm3} NA P{svm5} NA P{svm7} NA P{svm8} NA P{svm9} NA P{svm10} NA P{svm11} NA P{svm12} NA P{svm13} NA P{svm14} NA P{svmRDx3} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}svMB03697 No P{GawB}l(4)A6A6 No insertion of enhancer trap P{lacZ}svΔ122 No miscellaneous insertions flea{}sv35a NA flea{}svn NA opus{}svspa-1 NA P{hsp26-pt-T}sv4-M1030 NA Tirant{}svde NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity inferred from direct assay (Blanco et al., 2005)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) neuron development inferred from mutant phenotype (Parrish et al., 2006) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Blanco et al., 2005) regulation of R7 cell differentiation inferred from genetic interaction with pros (Charlton-Perkins et al., 2011) inferred from mutant phenotype (Charlton-Perkins et al., 2011) regulation of retinal cone cell fate specification inferred from genetic interaction with pros (Charlton-Perkins et al., 2011) inferred from mutant phenotype (Charlton-Perkins et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR001523 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity traceable author statement (Canon and Banerjee, 2000)
Biological Process
CV term Evidence References
compound eye cone cell fate commitment traceable author statement (Canon and Banerjee, 2000) regulation of transcription, DNA-dependent non-traceable author statement (Fu, 1997.6.26)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Fu, 1997.6.26)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions sv allele Gene References sv4G lz (Kaminker et al., 2001) sv5 P29 (Kavaler et al., 1999) sv6 P29 (Kavaler et al., 1999) sv7 P29 (Kavaler et al., 1999) sv8 P29 (Kavaler et al., 1999) sv+mFa Poxn (Jiao et al., 2001) svde H (Kavaler et al., 1999) svI lz (Kaminker et al., 2001) svScer\UAS.cKa CycE (Jiao et al., 2001) dm (Jiao et al., 2001) svsev.PB wg (Brunner et al., 1999) svsev.PJ Poxn (Jiao et al., 2001) svspa-pol BacA\p35 (Siddall et al., 2003) lz (Flores et al., 2000) Poxn (Jiao et al., 2001) rg (Shamloula et al., 2002) wg (Brunner et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68651 DroID - A comprehensive database of gene and protein interactions. • FBgn0005561 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43825
Orthologs
Genome-wide drosophilid orthologs	Dana\GF20618 Dere\GG16406 Dgri\GH23966 Dmoj\GI14046 Dper\GL18401 Dpse\spa-sv Dsec\GM13025 Dsim\GD24421 Dvir\GJ13730 Dwil\GK13586 Dyak\GE14566
Curated drosophilid orthologs	Dafs\reduced (Sturtevant, 1940, Sturtevant and Novitski, 1941) Dana\Shaven (Sturtevant and Novitski, 1941) Dbus\sv (Krivshenko, 1959) Dpse\GA22179   Dsim\Sv (Sturtevant and Novitski, 1941) Dvir\stu (Sturtevant and Novitski, 1941) Dvir\sy
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002348-PA Aedes aegypti (mosquito) XP_001943420.1 Acyrthosiphon pisum (pea aphid) 56669 Branchiostoma floridae (lancelet) ENSBTAP00000025783 Bos taurus (bovine) ENSCAFP00000003415 Canis familiaris (dog) CPIJ006382 Culex pipens (mosquito) ENSCPOP00000008962 Cavia porcellus (guinea pig) ENSDARP00000071454 Danio rerio (zebra fish) ENSECAP00000000604 Equus caballus (horse) ENSGACP00000011126 Gymnopilus aculeatus (mushroom) ENSGALP00000026460 Gallus gallus (chicken) ENSGALP00000039373 Gallus gallus (chicken) ENSP00000350844 Homo sapiens (human) ENSMODP00000003304 Monodelphis domestica (gray opossum) ENSMMUP00000015204 Macaca mulatta (rhesus monkey) ENSMUSP00000014174 Mus musculus (house mouse) ENSOANP00000012079 Ornithorynchus anatinus (platypus) ENSORLP00000009059 Oryzias latipes (japanese killifish) ENSORLP00000011687 Oryzias latipes (japanese killifish) PHUM011300-PA Pediculus humanus (human body louse) ENSPPYP00000021364 Pongo pygmaeus (orangutan) ENSPTRP00000049315 Pan troglodytes (chimpanzee) ENSRNOP00000040130 Rattus norvegicus (norway rat) ENSTNIP00000006290 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022349 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014326 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15883 LH21528 FBgn0232164 FBgn0215594 FBgn0200951 FBgn0195757 FBgn0167956 JGI_V11_311028 FBgn0249275 FBgn0156002 FBgn0131423 FBgn0108638 FBgn0097624 CPIJ006382 BGIBMGA013358 ACYPI000633 GB18397 AGAP000057 PHUM596300 GLEAN_03570
Stocks & Reagents
Stocks Listed in FlyBase ( 102 )
Bloomington	663 svn 4234 sv35a 658 svspa-1 1566 svspa-pol 642 ci1 svn 1400 Dp(4;Y)E, svspa-Cat/+
Kyoto	101790 svn 106030 svn 101788 svspa-1 101789 svspa-pol 106298 Dp(4;Y)E, svspa-Cat/+
VDRC	v107343 P{KK102302}VIE-260B
	More stocks available...
Genomic Clones ( 1 )
	BACR22J20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01047
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	107905 125425 145816 153996 159854 162569 CK01.54B.H2 CK01.56B.G3 EK044161 EK045526 EK209905 EK234156 EK247660 EK248564 EK258561 EK266524 EP18804 IP15123
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005561 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43825
Antibody Information
	polyclonal (Charlton-Perkins et al., 2011, Johnson et al., 2011)
Other Information
Discoverer
	Bridges, 14th Nov. 1920.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: sv Pax258 (FlyBase, 1996-) Source for merge of: sv spa (Fu et al., 1998)
Additional comments	Source for merge of sv Pax258 was sequence comparison (date:000202). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. RNAi of sv results in reduced arborization of ddaD and ddaE neurons, defects in muscle, alterations in the number of MD neurons and defects in dendrite morphogenesis. (Parrish et al., 2006) sv mutants results in a lack of sensory bristles, but has no phenotype in trichomes while sha mutants has no phenotype in bristles but results in a dramatic loss of denticles and trichomes. The sv and sha mutant phenotypes are thus distinct. (Adler, 1999.9.22) sv is a high level transcriptional regulator of shaft cell differentiation and acts downstream of the N signaling pathway as a specific link between cell fate determination and cell differentiation in the bristle cell lineage. (Kavaler et al., 1999) Flies carrying strong loss of function sv mutations specifically lack the shaft structures of the adult bristles. (Kavaler et al., 1999) sv has been cloned and sequenced. (Fu and Noll, 1997, Czerny et al., 1997) sv is required for the proper specification and differentiation of cone and primary pigment cells in the eye. (Fu and Noll, 1997) The mutation poliert, svspa-pol, is allelic to svspa-1. (Sturtevant, 1961)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079894 NM_166822 NM_001014697 NM_001014698 NM_001014699 NM_001014700 NM_001014701 NM_001169363 RefSeq (Proteins) • NP_524633 NP_726645 NP_001014697 NP_001014698 NP_001014699 NP_001014700 NP_001014701 NP_001162834 DDBJ / EMBL / GenBank • AAB70249 AAB86598 AAF59385 AAF59385.2 AAF59385.3 AAN06579 AAN06579.3 AAX53596 AAX53597 AAX53598 AAX53599 AAX53600 AC010577 AC018481 ACZ95103 AF010256 AF016888 Entrez Gene - A searchable database of RefSeq genes. • 43825 UniProtKB/TrEMBL • D1YSG9 O16117 O16804 Q8IM96 Q59DN6 Q59DN7 Q59DN8 Q59DN9 Q59DP0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Paired box protein, N-terminal (IPR001523) Homeodomain-like (IPR009057) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68651 DroID - A comprehensive database of gene and protein interactions. • FBgn0005561 DRSC - Results from RNAi screens. • FBgn0005561 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005561 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11049-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005561 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43825 InParanoid A subset of ortholog calls from InParanoid. • AAEL002348-PA Aedes aegypti (mosquito) XP_001943420.1 Acyrthosiphon pisum (pea aphid) 56669 Branchiostoma floridae (lancelet) ENSBTAP00000025783 Bos taurus (bovine) ENSCAFP00000003415 Canis familiaris (dog) CPIJ006382 Culex pipens (mosquito) ENSCPOP00000008962 Cavia porcellus (guinea pig) ENSDARP00000071454 Danio rerio (zebra fish) ENSECAP00000000604 Equus caballus (horse) ENSGACP00000011126 Gymnopilus aculeatus (mushroom) ENSGALP00000026460 Gallus gallus (chicken) ENSGALP00000039373 Gallus gallus (chicken) ENSP00000350844 Homo sapiens (human) ENSMODP00000003304 Monodelphis domestica (gray opossum) ENSMMUP00000015204 Macaca mulatta (rhesus monkey) ENSMUSP00000014174 Mus musculus (house mouse) ENSOANP00000012079 Ornithorynchus anatinus (platypus) ENSORLP00000009059 Oryzias latipes (japanese killifish) ENSORLP00000011687 Oryzias latipes (japanese killifish) PHUM011300-PA Pediculus humanus (human body louse) ENSPPYP00000021364 Pongo pygmaeus (orangutan) ENSPTRP00000049315 Pan troglodytes (chimpanzee) ENSRNOP00000040130 Rattus norvegicus (norway rat) ENSTNIP00000006290 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022349 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000014326 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/sparkln1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43825 modMine - Data generated by the modENCODE project. • FBgn0005561 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15883 LH21528 FBgn0232164 FBgn0215594 FBgn0200951 FBgn0195757 FBgn0167956 JGI_V11_311028 FBgn0249275 FBgn0156002 FBgn0131423 FBgn0108638 FBgn0097624 CPIJ006382 BGIBMGA013358 ACYPI000633 GB18397 AGAP000057 PHUM596300 GLEAN_03570 REDfly - A database of transcriptional regulatory elements. • FBgn0005561
Synonyms & Secondary IDs ( 31 )
Reported As
Symbol Synonym	Cat (Belgovsky, 1937, ) CG11049 (Keleman et al., 2009.8.5) D-pax-2 (Sundaram, 2005) D-Pax2 (Blanco et al., 2005, Kavaler et al., 2004, Siddall et al., 2003, Canon and Banerjee, 2003, Shilo, 2003, Pollock et al., 2003, Barolo and Posakony, 2002, Kronhamn et al., 2002, Jiao et al., 2001, Kaminker et al., 2001, Barolo et al., 2000, Ghazi and VijayRaghavan, 2000, Flores et al., 2000, Simon, 2000, Lai et al., 2000, Flores et al., 1999, Kavaler et al., 1999, Fu et al., 1998, Rogers and Barolo, 2006, Apitz et al., 2005, Nagaraj and Banerjee, 2007, Grillenzoni et al., 2007, Voas and Rebay, 2004, Pickup et al., 2009, Andrews et al., 2009, Dziedzic et al., 2009, Bhattacharya and Baker, 2009, Zhang et al., 2010, Johnson et al., 2011) Dpax2 (Gomes and Schweisguth, 2005, Cordero and Cagan, 2010) d-Pax2 (Parker and Kavaler, 2003) D-pax2 (Lai, 2002, Urbach, 2007) dPax2 (Barolo et al., 2002, Swanson et al., 2010, Charlton-Perkins et al., 2011) Dpax-2 (Canon and Banerjee, 2000, Bhattacharya and Baker, 2009) DPax-2 (Kaminker et al., 1999, Bhattacharya and Baker, 2009) dPax258 (Czerny, 1997.8.1, Czerny et al., 1997, ) en(lz)4G/I (Kaminker et al., 2001) l(4)40   Pax2 (Shilo, 2005, Kozmik, 2005, Hirth et al., 2003, Inbal et al., 2003, Hirth et al., 2003, Thompson and Kavaler, 2001, Swanson and Barolo, 2008, Hilgers et al., 2010, Swanson et al., 2010, Charlton-Perkins et al., 2011, Johnson et al., 2011) PAX2 (Moore et al., 2004) Pax2/5/8 (Reiner and Wullimann, 2004) pax2/sparkling (Bray and Furriols, 2001) Pax258   pol   shaven/sparkling (Jones et al., 2003) spa (Kozmik, 2005, Shamloula et al., 2002, Punzo et al., 2002, Jiao et al., 2001, Nepveu, 2001, Locke et al., 2000, Fu, 1997.6.26, Brunner et al., 1999, Behan et al., 1999, Fu and Noll, 1997, Bender, 1967, Sturtevant, 1961, Abrahamson et al., 1956, Rogers and Barolo, 2006, Nagaraj and Banerjee, 2007, Cordero and Cagan, 2010, Reig et al., 2007, Hartl et al., 2008, Gilliland et al., 2009, Montenegro et al., 2006, Wigby et al., 2009, Dziedzic et al., 2009, Swanson et al., 2010, Charlton-Perkins et al., 2011, Johnson et al., 2011) spa-sv (Sousa-Neves, 2000) sv (Hoskins et al., 2005, Cook, 2007.12.19, Riddle et al., 2008, Dziedzic et al., 2009, Perkins et al., 2009.8.10, Wang et al., 2004, Buffin and Gho, 2010, Sun et al., 2004, Friedrich and Caravas, 2011, Johnson et al., 2011) Sv (Parrish et al., 2006, Miller et al., 2009, Charlton-Perkins et al., 2011)
Name Synonym	Cataract   poliert   shaven (Miller et al., 2009, Dziedzic et al., 2009, Buffin and Gho, 2010, Friedrich and Caravas, 2011, Charlton-Perkins et al., 2011, Johnson et al., 2011) Shaven (Cho et al., 2005, Pickup et al., 2009) sparkling (Pichaud and Desplan, 2002, Galliot et al., 1999, Fu and Noll, 1997, Bender, 1967, Sturtevant, 1961, Abrahamson et al., 1956, Cordero and Cagan, 2010, Reig et al., 2007, Wigby et al., 2009, Dziedzic et al., 2009, Swanson et al., 2010, Charlton-Perkins et al., 2011, Johnson et al., 2011) Sparkling (Nagaraj and Banerjee, 2000) sparklin poliert (Montenegro et al., 2006)
Secondary FlyBase IDs
	FBgn0003468 FBgn0003649 FBgn0004541 FBgn0020913
References ( 160 )
Generate a list of	All references relating to this gene ( 160 )
List References by type	Research paper  ( 95 ) Supplementary material  ( 2 ) Review  ( 21 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 21 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 2 ) Book  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Stock list  ( 1 )
Recent research papers ( 9 )
	Charlton-Perkins et al., 2011, Neural Dev. 6: 20 Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. [FBrf0213993] Friedrich and Caravas, 2011, J. Exp. Zool. B Mol. Dev. Evol. 316(6): 387--392 New insights from hemichordate genomes: prebilaterian origin and parallel modifications in the paired domain of the Pax gene eyegone. [FBrf0214613] Johnson et al., 2011, Dev. Dyn. 240(7): 1769--1778 Discrete regulatory regions control early and late expression of D-Pax2 during external sensory organ development. [FBrf0213950] Swanson et al., 2011, Curr. Biol. 21(14): 1186--1196 Rapid evolutionary rewiring of a structurally constrained eye enhancer. [FBrf0214461] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039] Cordero and Cagan, 2010, Dev. Dyn. 239(3): 875--884 Canonical wingless signaling regulates cone cell specification in the Drosophila retina. [FBrf0210104] Hilgers et al., 2010, PLoS Biol. 8(6): e1000396 Drosophila microRNAs 263a/b Confer Robustness during Development by Protecting Nascent Sense Organs from Apoptosis. [FBrf0211074] Swanson et al., 2010, Dev. Cell 18(3): 359--370 Structural Rules and Complex Regulatory Circuitry Constrain Expression of a Notch- and EGFR-Regulated Eye Enhancer. [FBrf0210200] Zhang et al., 2010, Mol. Cell. Biol. 30(5): 1158--1170 Sterile Alpha Motif Domain-Mediated Self-Association Plays an Essential Role in Modulating the Activity of the Drosophila ETS Family Transcriptional Repressor Yan. [FBrf0209952] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...