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Gene Dmel\Crc

General Information
Symbol	Dmel\Crc	Species	D. melanogaster
Name	Calreticulin	Annotation symbol	CG9429
Feature type	protein_coding_gene	FlyBase ID	FBgn0005585
Gene Model Status	Current	Stock availability	20 publicly available
Also Known As	potp
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	85E1-85E1	Sequence location	3R:5,454,660..5,456,607 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Calreticulin is referred to in FlyBase by the symbol Dmel\Crc (CG9429, FBgn0005585). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium ion binding. There is experimental evidence that it is involved in the biological process: central nervous system development; startle response; brain morphogenesis; olfactory behavior; locomotion involved in locomotory behavior; neurogenesis. 39 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; presumptive embryonic/larval peripheral nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Calreticulin; Calreticulin/calnexin; Calreticulin/calnexin, conserved site; Concanavalin A-like lectin/glucanase; Concanavalin A-like lectin/glucanase, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Comments on Affy2 ProbeSet: ProbeSet 1639441_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Crc. Gene sequence location is 3R:5454660..5456607.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Carreira et al., 2011, BMC Dev. Biol. 11: 32 Sequence features HFA16614 BKN21487
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E1-85E1   Limits computationally determined from genome sequence between P{EP}CG9393EP3122 and P{EP}CrcEP3006
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85E1-85E1   (determined by in situ hybridisation)   (Prokopenko et al., 2000) 85E-85E   (determined by in situ hybridisation)   (Prokopenko, 2000.3.4) 85E-85E     (Prokopenko, 1999.8.5) 85E-85E     (Prokopenko, 1999.8.5) 86B-86C     (Gamo, 1997.1.26) 86B-86C   (determined by in situ hybridisation) 84E--F (determined by in situ hybridisation)   (Gamo et al., 1998) 85E-85E   (determined by in situ hybridisation)   (Salzberg et al., 1997) 86B-86C   (determined by in situ hybridisation)   (Dodo et al., 1995) 85E1-85E2   (determined by in situ hybridisation)   (Christodoulou et al., 1997) 86B-86C   (determined by in situ hybridisation)   (Dodo et al., 1995)
Experimentally Determined Recombination Data
Location	3- (Dodo et al., 1995)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Crc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Crc-RA FBtr0082103  NM_079569   1464   406
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Crc-PA   FBpp0081581   46.8   406   4.17     NP_524293   AAF54416
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Calreticulin/calnexin, conserved site (IPR018124) Calreticulin/calnexin (IPR001580) Concanavalin A-like lectin/glucanase (IPR008985) Calreticulin (IPR009169) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141150   AA202453   AA246318   AA264422   AA264548   AA433289   AA694791   AA695232   AA695389   AA695434   AA695453   AA695485   AA695963   AA695991   AA696072   AA696264   AA735839   AA735865   AA801954   AA802115   AA802559   AA802589   AA803142   AA804072   AA940707   AA941554   AE014297 AAF54416   AB000718 BAA85379   AF175911   AF175912   AF175913   AF175914   AI063484   AI063759   AI107846   AI108511   AI109366   AI109460   AI110023   AI124298   AI124304   AI258447   AI258650   AI258920   AI259655   AI260211   AI260218   AI260965   AI293480   AI293647   AI294806   AI294812   AI295085   AI295213   AI295632   AI295785   AI388283   AI403107   AI405220   AI405411   AI530936   AI533529   AI534461   AI544163   AK255342   AQ025171   AQ025213   AQ073788   AQ254648   AQ254686   AY431567   AY440467   BE978469   BF489661   BF489743   BF491813   BF492717   BF492718   BF494707   BF501847   BF504638   BF504640   BF504667   BF506548   BG636449   BG636492   BG636899   BG636929   BG640782   BG640807   BG641113   BG641264   BG641399   BH615026   BI142023   BI142225   BI163873   BI165512   BI165994   BI166352   BI171875   BI173176   BI173410   BI212380   BI212466   BI213890   BI214537   BI228245   BI228510   BI231749   BI231795   BI234139   BI234361   BI237791   BI239853   BI240975   BI352736   BI353940   BI353955   BI361984   BI362383   BI364890   BI364893   BI366409   BI368659   BI369049   BI369949   BI370249   BI370645   BI371555   BI371638   BI372937   BI375547   BI482415   BI482791   BI482836   BI483177   BI484399   BI484978   BI486143   BI486164   BI578978   BI579656   BI580752   BI592062   BI617768   BI618266   BI618719   BI625408   BI625626   BI632258   BI632412   BI632474   BI632756   BI632768   BI632824   BI632965   BI633462   BI633914   BI635052   BI635571   BI635794   BI635816   BI635884   BI635931   BI636338   BI636393   BI636619   BI636700   BI636717   BI636799   BI636889   BI637596   BI637598   BI637661   BI638493   BI638892   BI639623   BI639780   BI640481   BI640509   BI641250   BI641735   BP544666   BP544667   BP546508   BP546784   BP547589   BP547958   BP552661   BP552662   BP553354   BP553355   BP554428   BP554429   BP554910   BP554911   BP555490   BP555491   BP557054   BP557055   BP557333   BP560249   BP560250   BT001670 AAN71425   BX007432   BX064224   CA804346   CA804462   CA806222   CA807025   CK132113   CK132291   CK657148   CK657380   CK657531   CK657545   CK658573   CK658761   CK658850   CK659561   CK659650   CK660129   CK660691   CK660973   CK661293   CK661680   CL610128   CO154669   CO155308   CO156567   CO156778   CO157093   CO183179   CO184848   CO191766   CO193707   CO268341   CO269283   CO272616   CO272798   CO273996   CO278413   CO279460   CO288506   CO288690   CO289148   CO293244   CO301169   CO313199   CO324723   CZ483009   EC058689   EC058729   EC061515   EC063723   EC063817   EC065179   EC072627   EC197923   EC206541   EC209586   EC213438   EC220031   EC220899   EC223173   EC230618   EC231574   EC243777   EC246776   EC246880   EC260997   EC261312   EC265789   EC266558   EL887387   EL887525   ES690080   ES690091   ES690134   ES690136   ES690142   ES692161   ES692166   ES692181   ES692182   ES692186   ES692187   ES692188   ES692189   ES692190   ES692191   ES692193   ES692194   ES692195   ES692196   ES692197   ES692198   ES692199   ES692200   ES692201   ES692203   ES692204   ES692205   ES692207   ES692208   ES692792   ES694410   ES694492   ES694507   ES694516   ES694521   ES694905   ES694955   ES694961   ES694962   ES694974   ES695038   ES695120   EV578677   EV580781   EV582962   EV585730   EV587198   EV588892   EV595211   EV597341   GH749178   GH751633   GH753411   GH756986   GH757470   GH758598   GH770174   GH771750   GH772432   GH778958   GH779161   GH785747   GH795004   GH795054   GH795518   GH795881   GH797676   GH798485   GH799242   GH799597   GH800789   GH801367   GH804612   GH805591   GH806588   GH809414   GH809423   GH809828   GH811749   GH812236   GH815562   GH818115   GH818913   GH819131   GH821500   GH822741   GH827040   GH830145   GH831949   GH833365   GH834019   GH838867   GH841658   GH845481   GH849076   GH853968   GH854643   GH855432   GH859115   GH861514   GH863122   GH866873   GH868092   GH878021   GH878323   GH879429   GH883049   GH883284   GH890837   GH893938   GH898634   GH900180   GH904256   GH904972   GH912548   GH912724   GH913638   GH913858   GH920033   GH920258   GH921125   GH928890   GH929622   GH933306   GH933378   GH934645   X64461 CAA45791
UniProtKB/Swiss-Prot	P29413
UniProtKB/TrEMBL	Q53YH3 Q9U916
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   somatic cell   • perinuclear region of cytoplasm (Gamo et al., 2003) embryonic stage 9   organism | ubiquitous   (Gamo et al., 2003) ventral neurogenic region   (Gamo et al., 2003) procephalic neurogenic region   (Gamo et al., 2003) embryonic stage 15   embryonic ventral nervous system   (Gamo et al., 2003) embryonic/larval trachea   (Gamo et al., 2003) embryonic hindgut   (Gamo et al., 2003) embryonic/larval midgut primordium   (Gamo et al., 2003) presumptive embryonic salivary gland   (Gamo et al., 2003) third instar larval stage   embryonic/larval optic lobe   (Gamo et al., 2003) Comment:outer surface neurons most strongly stained larval outer optic anlage   (Gamo et al., 2003) ventral nerve cord | faint   (Gamo et al., 2003) wing disc   (Gamo et al., 2003) ventral thoracic disc   (Gamo et al., 2003) pupal stage P6   optic lobe   (Gamo et al., 2003) Comment:19 hr APF pharate adult stage P8   optic lobe   • neuronal cell body (Gamo et al., 2003) Comment:48 hr APF adult brain   • neuronal cell body (Gamo et al., 2003) Comment:48 hr APF subesophageal ganglion   • neuronal cell body (Gamo et al., 2003) Comment:48 hr APF pharate adult stage P15 -- adult stage   brain | faint   (Gamo et al., 2003) optic lobe | faint   (Gamo et al., 2003) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Gamo et al., 2003) Comment:highest expression in third instar larvae and pupae
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0005585    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0005585 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0005585 expression level Developmental Stage   Expression Level embryo 00-02hr    31402 embryo 02-04hr    28061 embryo 04-06hr    67525 embryo 06-08hr    119171 embryo 08-10hr    112530 embryo 10-12hr    128562 embryo 12-14hr    105838 embryo 14-16hr    65212 embryo 16-18hr    40664 embryo 18-20hr    28751 embryo 20-22hr    19968 embryo 22-24hr    19812 larva L1    50972 larva L2    77575 larva L3 12hr old    54706 larva L3 puffstage 1-2    38101 larva L3 puffstage 3-6    43142 larva L3 puffstage 7-9    45852 white prepupae new    54417 white prepupae 12hr    37331 white prepupae 24hr    62334 pupae 2d postWPP    51127 pupae 3d postWPP    19394 pupae 4d postWPP    16440 adult male 01day    32846 adult male 05day    34222 adult male 30day    38728 adult female 01day    29301 adult female 05day    34722 adult female 30day    37249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (31402) embryo 02-04hr  (28061) embryo 04-06hr  (67525) embryo 06-08hr  (119171) embryo 08-10hr  (112530) embryo 10-12hr  (128562) embryo 12-14hr  (105838) embryo 14-16hr  (65212) embryo 16-18hr  (40664) embryo 18-20hr  (28751) embryo 20-22hr  (19968) embryo 22-24hr  (19812) larva L1  (50972) larva L2  (77575) larva L3 12hr old  (54706) larva L3 puffstage 1-2  (38101) larva L3 puffstage 3-6  (43142) larva L3 puffstage 7-9  (45852) white prepupae new  (54417) white prepupae 12hr  (37331) white prepupae 24hr  (62334) pupae 2d postWPP  (51127) pupae 3d postWPP  (19394) pupae 4d postWPP  (16440) adult male 01day  (32846) adult male 05day  (34222) adult male 30day  (38728) adult female 01day  (29301) adult female 05day  (34722) adult female 30day  (37249) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (31402) embryo 02-04hr  (28061) embryo 04-06hr  (67525) embryo 06-08hr  (119171) embryo 08-10hr  (112530) embryo 10-12hr  (128562) embryo 12-14hr  (105838) embryo 14-16hr  (65212) embryo 16-18hr  (40664) embryo 18-20hr  (28751) embryo 20-22hr  (19968) embryo 22-24hr  (19812) larva L1  (50972) larva L2  (77575) larva L3 12hr old  (54706) larva L3 puffstage 1-2  (38101) larva L3 puffstage 3-6  (43142) larva L3 puffstage 7-9  (45852) white prepupae new  (54417) white prepupae 12hr  (37331) white prepupae 24hr  (62334) pupae 2d postWPP  (51127) pupae 3d postWPP  (19394) pupae 4d postWPP  (16440) adult male 01day  (32846) adult male 05day  (34222) adult male 30day  (38728) adult female 01day  (29301) adult female 05day  (34722) adult female 30day  (37249) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (31402) embryo 02-04hr  (28061) embryo 04-06hr  (67525) embryo 06-08hr  (119171) embryo 08-10hr  (112530) embryo 10-12hr  (128562) embryo 12-14hr  (105838) embryo 14-16hr  (65212) embryo 16-18hr  (40664) embryo 18-20hr  (28751) embryo 20-22hr  (19968) embryo 22-24hr  (19812) larva L1  (50972) larva L2  (77575) larva L3 12hr old  (54706) larva L3 puffstage 1-2  (38101) larva L3 puffstage 3-6  (43142) larva L3 puffstage 7-9  (45852) white prepupae new  (54417) white prepupae 12hr  (37331) white prepupae 24hr  (62334) pupae 2d postWPP  (51127) pupae 3d postWPP  (19394) pupae 4d postWPP  (16440) adult male 01day  (32846) adult male 05day  (34222) adult male 30day  (38728) adult female 01day  (29301) adult female 05day  (34722) adult female 30day  (37249) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31402 embryo 02-04hr    28061 embryo 04-06hr    67525 embryo 06-08hr    119171 embryo 08-10hr    112530 embryo 10-12hr    128562 embryo 12-14hr    105838 embryo 14-16hr    65212 embryo 16-18hr    40664 embryo 18-20hr    28751 embryo 20-22hr    19968 embryo 22-24hr    19812 larva L1    50972 larva L2    77575 larva L3 12hr old    54706 larva L3 puffstage 1-2    38101 larva L3 puffstage 3-6    43142 larva L3 puffstage 7-9    45852 white prepupae new    54417 white prepupae 12hr    37331 white prepupae 24hr    62334 pupae 2d postWPP    51127 pupae 3d postWPP    19394 pupae 4d postWPP    16440 adult male 01day    32846 adult male 05day    34222 adult male 30day    38728 adult female 01day    29301 adult female 05day    34722 adult female 30day    37249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0005585 expression level Developmental Stage   Expression Level embryo 00-02hr    31402 embryo 02-04hr    28061 embryo 04-06hr    67525 embryo 06-08hr    119171 embryo 08-10hr    112530 embryo 10-12hr    128562 embryo 12-14hr    105838 embryo 14-16hr    65212 embryo 16-18hr    40664 embryo 18-20hr    28751 embryo 20-22hr    19968 embryo 22-24hr    19812 larva L1    50972 larva L2    77575 larva L3 12hr old    54706 larva L3 puffstage 1-2    38101 larva L3 puffstage 3-6    43142 larva L3 puffstage 7-9    45852 white prepupae new    54417 white prepupae 12hr    37331 white prepupae 24hr    62334 pupae 2d postWPP    51127 pupae 3d postWPP    19394 pupae 4d postWPP    16440 adult male 01day    32846 adult male 05day    34222 adult male 30day    38728 adult female 01day    29301 adult female 05day    34722 adult female 30day    37249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (31402) embryo 02-04hr  (28061) embryo 04-06hr  (67525) embryo 06-08hr  (119171) embryo 08-10hr  (112530) embryo 10-12hr  (128562) embryo 12-14hr  (105838) embryo 14-16hr  (65212) embryo 16-18hr  (40664) embryo 18-20hr  (28751) embryo 20-22hr  (19968) embryo 22-24hr  (19812) larva L1  (50972) larva L2  (77575) larva L3 12hr old  (54706) larva L3 puffstage 1-2  (38101) larva L3 puffstage 3-6  (43142) larva L3 puffstage 7-9  (45852) white prepupae new  (54417) white prepupae 12hr  (37331) white prepupae 24hr  (62334) pupae 2d postWPP  (51127) pupae 3d postWPP  (19394) pupae 4d postWPP  (16440) adult male 01day  (32846) adult male 05day  (34222) adult male 30day  (38728) adult female 01day  (29301) adult female 05day  (34722) adult female 30day  (37249) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (31402) embryo 02-04hr  (28061) embryo 04-06hr  (67525) embryo 06-08hr  (119171) embryo 08-10hr  (112530) embryo 10-12hr  (128562) embryo 12-14hr  (105838) embryo 14-16hr  (65212) embryo 16-18hr  (40664) embryo 18-20hr  (28751) embryo 20-22hr  (19968) embryo 22-24hr  (19812) larva L1  (50972) larva L2  (77575) larva L3 12hr old  (54706) larva L3 puffstage 1-2  (38101) larva L3 puffstage 3-6  (43142) larva L3 puffstage 7-9  (45852) white prepupae new  (54417) white prepupae 12hr  (37331) white prepupae 24hr  (62334) pupae 2d postWPP  (51127) pupae 3d postWPP  (19394) pupae 4d postWPP  (16440) adult male 01day  (32846) adult male 05day  (34222) adult male 30day  (38728) adult female 01day  (29301) adult female 05day  (34722) adult female 30day  (37249) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (31402) embryo 02-04hr  (28061) embryo 04-06hr  (67525) embryo 06-08hr  (119171) embryo 08-10hr  (112530) embryo 10-12hr  (128562) embryo 12-14hr  (105838) embryo 14-16hr  (65212) embryo 16-18hr  (40664) embryo 18-20hr  (28751) embryo 20-22hr  19968 embryo 22-24hr  19812 larva L1  (50972) larva L2  (77575) larva L3 12hr old  (54706) larva L3 puffstage 1-2  (38101) larva L3 puffstage 3-6  (43142) larva L3 puffstage 7-9  (45852) white prepupae new  (54417) white prepupae 12hr  (37331) white prepupae 24hr  (62334) pupae 2d postWPP  (51127) pupae 3d postWPP  19394 pupae 4d postWPP  16440 adult male 01day  (32846) adult male 05day  (34222) adult male 30day  (38728) adult female 01day  (29301) adult female 05day  (34722) adult female 30day  (37249) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31402 embryo 02-04hr    28061 embryo 04-06hr    67525 embryo 06-08hr    119171 embryo 08-10hr    112530 embryo 10-12hr    128562 embryo 12-14hr    105838 embryo 14-16hr    65212 embryo 16-18hr    40664 embryo 18-20hr    28751 embryo 20-22hr    19968 embryo 22-24hr    19812 larva L1    50972 larva L2    77575 larva L3 12hr old    54706 larva L3 puffstage 1-2    38101 larva L3 puffstage 3-6    43142 larva L3 puffstage 7-9    45852 white prepupae new    54417 white prepupae 12hr    37331 white prepupae 24hr    62334 pupae 2d postWPP    51127 pupae 3d postWPP    19394 pupae 4d postWPP    16440 adult male 01day    32846 adult male 05day    34222 adult male 30day    38728 adult female 01day    29301 adult female 05day    34722 adult female 30day    37249 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0005585    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0005585 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0005585 expression level Tissue   Expression Level Larval Central Nervous System    1613.175 Larval Midgut    1725.1 Larval Hindgut    1766.9 Larval Malpighian Tubules    2826.6 Larval Fat Body    3595.1 Larval Salivary Gland    5044.6 Larval Trachea    2877.6 Larval Carcass    2067.65 Adult Head    1311.5 Adult Eye    1511.85 Adult Brain    935.9 Adult Thoracic-Abdominal Ganglion    1022 Adult Crop    1365.2 Adult Midgut    1693.8 Adult Hindgut    1485.1 Adult Malpighian Tubules    2111.2 Adult Fat Body    1303.8 Adult Salivary Gland    4254.3 Adult Heart    1551.025 Adult VirginFemale Spermatheca    1737 Adult InseminatedFemale Spermatheca    2045.1 Adult Ovary    1222.7 Adult Testis    454.8 Adult Male Accessory Gland    8137.7 Adult Carcass    1187.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1613.175) Larval Midgut  (1725.1) Larval Hindgut  (1766.9) Larval Malpighian Tubules  (2826.6) Larval Fat Body  (3595.1) Larval Salivary Gland  (5044.6) Larval Trachea  (2877.6) Larval Carcass  (2067.65) Adult Head  (1311.5) Adult Eye  (1511.85) Adult Brain  (935.9) Adult Thoracic-Abdominal Ganglion  (1022) Adult Crop  (1365.2) Adult Midgut  (1693.8) Adult Hindgut  (1485.1) Adult Malpighian Tubules  (2111.2) Adult Fat Body  (1303.8) Adult Salivary Gland  (4254.3) Adult Heart  (1551.025) Adult VirginFemale Spermatheca  (1737) Adult InseminatedFemale Spermatheca  (2045.1) Adult Ovary  (1222.7) Adult Testis    454.8 Adult Male Accessory Gland  (8137.7) Adult Carcass  (1187.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1613.175) Larval Midgut  (1725.1) Larval Hindgut  (1766.9) Larval Malpighian Tubules  (2826.6) Larval Fat Body  (3595.1) Larval Salivary Gland  (5044.6) Larval Trachea  (2877.6) Larval Carcass  (2067.65) Adult Head  (1311.5) Adult Eye  (1511.85) Adult Brain    935.9 Adult Thoracic-Abdominal Ganglion  1022 Adult Crop  (1365.2) Adult Midgut  (1693.8) Adult Hindgut  (1485.1) Adult Malpighian Tubules  (2111.2) Adult Fat Body  (1303.8) Adult Salivary Gland  (4254.3) Adult Heart  (1551.025) Adult VirginFemale Spermatheca  (1737) Adult InseminatedFemale Spermatheca  (2045.1) Adult Ovary  (1222.7) Adult Testis    454.8 Adult Male Accessory Gland  (8137.7) Adult Carcass  (1187.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1613.175 Larval Midgut    1725.1 Larval Hindgut    1766.9 Larval Malpighian Tubules    2826.6 Larval Fat Body    3595.1 Larval Salivary Gland    5044.6 Larval Trachea    2877.6 Larval Carcass    2067.65 Adult Head    1311.5 Adult Eye    1511.85 Adult Brain    935.9 Adult Thoracic-Abdominal Ganglion    1022 Adult Crop    1365.2 Adult Midgut    1693.8 Adult Hindgut    1485.1 Adult Malpighian Tubules    2111.2 Adult Fat Body    1303.8 Adult Salivary Gland    4254.3 Adult Heart    1551.025 Adult VirginFemale Spermatheca    1737 Adult InseminatedFemale Spermatheca    2045.1 Adult Ovary    1222.7 Adult Testis    454.8 Adult Male Accessory Gland    8137.7 Adult Carcass    1187.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0005585 expression level Tissue   Expression Level Larval Central Nervous System    1613.175 Larval Midgut    1725.1 Larval Hindgut    1766.9 Larval Malpighian Tubules    2826.6 Larval Fat Body    3595.1 Larval Salivary Gland    5044.6 Larval Trachea    2877.6 Larval Carcass    2067.65 Adult Head    1311.5 Adult Eye    1511.85 Adult Brain    935.9 Adult Thoracic-Abdominal Ganglion    1022 Adult Crop    1365.2 Adult Midgut    1693.8 Adult Hindgut    1485.1 Adult Malpighian Tubules    2111.2 Adult Fat Body    1303.8 Adult Salivary Gland    4254.3 Adult Heart    1551.025 Adult VirginFemale Spermatheca    1737 Adult InseminatedFemale Spermatheca    2045.1 Adult Ovary    1222.7 Adult Testis    454.8 Adult Male Accessory Gland    8137.7 Adult Carcass    1187.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1613.175) Larval Midgut  (1725.1) Larval Hindgut  (1766.9) Larval Malpighian Tubules  (2826.6) Larval Fat Body  (3595.1) Larval Salivary Gland  (5044.6) Larval Trachea  (2877.6) Larval Carcass  (2067.65) Adult Head  (1311.5) Adult Eye  (1511.85) Adult Brain  (935.9) Adult Thoracic-Abdominal Ganglion  (1022) Adult Crop  (1365.2) Adult Midgut  (1693.8) Adult Hindgut  (1485.1) Adult Malpighian Tubules  (2111.2) Adult Fat Body  (1303.8) Adult Salivary Gland  (4254.3) Adult Heart  (1551.025) Adult VirginFemale Spermatheca  (1737) Adult InseminatedFemale Spermatheca  (2045.1) Adult Ovary  (1222.7) Adult Testis    454.8 Adult Male Accessory Gland  (8137.7) Adult Carcass  (1187.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1613.175 Larval Midgut  (1725.1) Larval Hindgut  (1766.9) Larval Malpighian Tubules  (2826.6) Larval Fat Body  (3595.1) Larval Salivary Gland  (5044.6) Larval Trachea  (2877.6) Larval Carcass  (2067.65) Adult Head  1311.5 Adult Eye  1511.85 Adult Brain    935.9 Adult Thoracic-Abdominal Ganglion  1022 Adult Crop  1365.2 Adult Midgut  1693.8 Adult Hindgut  1485.1 Adult Malpighian Tubules  (2111.2) Adult Fat Body  1303.8 Adult Salivary Gland  (4254.3) Adult Heart  1551.025 Adult VirginFemale Spermatheca  (1737) Adult InseminatedFemale Spermatheca  (2045.1) Adult Ovary  1222.7 Adult Testis    454.8 Adult Male Accessory Gland  (8137.7) Adult Carcass  1187.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1613.175 Larval Midgut    1725.1 Larval Hindgut    1766.9 Larval Malpighian Tubules    2826.6 Larval Fat Body    3595.1 Larval Salivary Gland    5044.6 Larval Trachea    2877.6 Larval Carcass    2067.65 Adult Head    1311.5 Adult Eye    1511.85 Adult Brain    935.9 Adult Thoracic-Abdominal Ganglion    1022 Adult Crop    1365.2 Adult Midgut    1693.8 Adult Hindgut    1485.1 Adult Malpighian Tubules    2111.2 Adult Fat Body    1303.8 Adult Salivary Gland    4254.3 Adult Heart    1551.025 Adult VirginFemale Spermatheca    1737 Adult InseminatedFemale Spermatheca    2045.1 Adult Ovary    1222.7 Adult Testis    454.8 Adult Male Accessory Gland    8137.7 Adult Carcass    1187.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1311.5   NA  Eye    1511.85   NA  Brain    935.9   1613.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1022   NA  Crop    1365.2   1725.1  Midgut    1693.8   1766.9  Hindgut    1485.1   2826.6  Malpighian Tubules    2111.2   3595.1  Fat Body    1303.8   5044.6  Salivary Gland    4254.3   NA  Heart    1551.025   2877.6  Trachea    NA   NA  VirginFemale Spermatheca    1737   NA  InseminatedFemale Spermatheca    2045.1   NA  Ovary    1222.7   NA  Testis    454.8   NA  Male Accessory Gland    8137.7   2067.65  Carcass    1187.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005585 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9429-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 CrcGD4328 lethal (with Crc10d), with Scer\GAL4[-]: CrcEP1084 lethal (with Crc10rv), with Scer\GAL4[-]: CrcEP1084 lethal (with CrcEP834), with Scer\GAL4[-]: CrcEP3167 lethal (with CrcEP1084), with Scer\GAL4[-]: Crc10d Crc10rv lethal (with CrcEP3167), with Scer\GAL4[-]: CrcEP834 lethal | recessive Crcs20-1 CrcS114307 lethal | recessive, with Scer\GAL4[-]: CrcEP834 CrcEP3167 viable CrcBG02115 CrcBG02566 CrcCA06507 CrcEY03142 viable (with Crc10d), with Scer\GAL4[-]: CrcEP834 CrcEP3167 viable (with Crc10rv), with Scer\GAL4[-]: CrcEP834 CrcEP3167 viable (with CrcEP834), with Scer\GAL4[-]: Crc10d Crc10rv CrcEP1084 viable (with CrcEP1084), with Scer\GAL4[-]: CrcEP834 CrcEP3167 viable (with CrcEP3167), with Scer\GAL4[-]: Crc10d Crc10rv CrcEP1084 Sterility Allele fertile CrcEY03142 fertile (with Crc10d), with Scer\GAL4[-]: CrcEP834 CrcEP3167 fertile (with Crc10rv), with Scer\GAL4[-]: CrcEP834 CrcEP3167 fertile (with CrcEP834), with Scer\GAL4[-]: Crc10d Crc10rv CrcEP1084 fertile (with CrcEP1084), with Scer\GAL4[-]: CrcEP834 CrcEP3167 fertile (with CrcEP3167), with Scer\GAL4[-]: Crc10d Crc10rv CrcEP1084 Other Phenotypes Allele chemical resistant Crceth-as311 chemical sensitive Crceth-as311 chemical sensitive | recessive Crceth-as307 Crceth-as311 neuroanatomy defective | larval stage, with Scer\GAL41407 CrcGD4328 smell perception defective CrcBG02115 CrcBG02566 smell perception defective (with Crc10d), with Scer\GAL4[-]: CrcEP3167 smell perception defective (with CrcEP834), with Scer\GAL4[-]: CrcEP1084 smell perception defective (with CrcEP1084), with Scer\GAL4[-]: CrcEP834 CrcEP3167 smell perception defective (with CrcEP3167), with Scer\GAL4[-]: Crc10d CrcEP1084 smell perception defective | recessive Crc10d Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 CrcGD4328 ganglion mother cell | larval stage, with Scer\GAL41407 CrcGD4328 macrochaeta CrcBG01724 CrcBG02115 CrcBG02220 CrcBG02566 CrcBG02646 neuron | embryonic stage CrcS114307 presumptive embryonic/larval peripheral nervous system CrcS114307
Classical Alleles ( 36 )
For All Classical Alleles Show
Allele of Crc Class Mutagen Stocks Known lesion Crc05 1 Yes Crc5-HA-1658 1 -- Crc5-HA-1919 1 -- CrcBG02738 P-element activity 1 -- CrcCB-5036-3 1 -- CrcCB-6470-3 1 -- Crcd03868 1 -- CrcDG09802 1 -- CrcEY03142 P-element activity 1 -- Crcf00548 piggyBac transposase 1 -- CrcNP0736 1 -- CrcNP0745 1 -- CrcNP4410 1 -- CrcNP5369 1 -- CrcNP6619 1 -- CrcNP7498 1 -- CrcNP7523 1 -- CrcS114307 P-element activity 1 Yes Crc10d loss of function allele Delta2-3 0 Yes Crc10rv Delta2-3 0 Yes CrcBG01724 P-element activity 0 Yes CrcBG02115 P-element activity 0 Yes CrcBG02220 P-element activity 0 Yes CrcBG02566 P-element activity 0 Yes CrcBG02646 P-element activity 0 Yes CrcCA06507 P-element activity 0 Yes CrcCB-5028-3 0 -- CrcEP1084 loss of function allele P-element activity 0 -- CrcEP3006 P-element activity 0 -- CrcEP3167 loss of function allele P-element activity 0 -- CrcEP834 loss of function allele P-element activity 0 -- CrcEP979 P-element activity 0 -- Crceth-as307 P-element activity 0 -- Crceth-as311 P-element activity 0 Yes CrcNP4492 0 -- Crcs20-1 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Crc Class Mutagen Stocks Known lesion CrcGD4328 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CrcAct5C.T:Avic\GFP,T:Uuuu\KDEL in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Crchs.PG 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6153 (Ryder, 2004.4.26) Df(3R)Exel6264 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4328} NA heat-shock construct P{hs-Crc.G} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CrcEP834 NA P{EP}CrcEP979 NA P{EP}CrcEP1084 NA P{EP}CrcEP3006 NA P{EP}CrcEP3167 NA P{EP}EP3321 NA P{EPgy2}CrcEY03142 NA P{XP}Crcd03868 NA miscellaneous insertions P{}Crceth-as307 NA P{}Crceth-as311 NA P{GT1}CrcBG01724 NA P{GT1}CrcBG02115 NA P{GT1}CrcBG02220 NA P{GT1}CrcBG02566 NA P{GT1}CrcBG02646 NA P{GT1}CrcBG02738 NA P{PTT-GA}CrcCA06507 NA P{RS3}CrcCB-5028-3 NA P{RS3}CrcCB-5036-3 NA P{RS3}CrcCB-6470-3 NA P{RS5}Crc5-HA-1658 NA P{RS5}Crc5-HA-1919 NA P{UAST-YFP.Rab2.S20N}Crc05 NA P{wHy}CrcDG09802 NA PBac{WH}Crcf00548 NA insertion of enhancer trap binary system P{GawB}CrcNP0736 No P{GawB}CrcNP0745 No P{GawB}CrcNP4410 No P{GawB}CrcNP4492 No P{GawB}CrcNP5369 No P{GawB}CrcNP6619 No P{GawB}CrcNP7498 No P{GawB}CrcNP7523 No insertion of enhancer trap P{lacW}CrcS114307 No P{luc-sniffer}SpdS1 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
brain morphogenesis inferred from mutant phenotype (Yamamoto et al., 2008) central nervous system development inferred from mutant phenotype (Prokopenko et al., 2000) locomotion involved in locomotory behavior inferred from mutant phenotype (Yamamoto et al., 2008) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) olfactory behavior inferred from mutant phenotype (Stoltzfus et al., 2003, Sambandan et al., 2006) startle response inferred from mutant phenotype (Yamamoto et al., 2008)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Walker et al., 2006) fusome inferred from direct assay (Lighthouse et al., 2008) lipid particle inferred from direct assay (Beller et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from sequence or structural similarity with UniProtKB:P15253 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) unfolded protein binding inferred from electronic annotation with InterPro:IPR009169 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
peripheral nervous system development traceable author statement (Prokopenko et al., 2000) protein folding inferred from electronic annotation with InterPro:IPR009169 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
endoplasmic reticulum lumen inferred from sequence or structural similarity with UniProtKB:P15253 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1993.4.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Crc allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66325 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005585 DroID - A comprehensive database of gene and protein interactions. • FBgn0005585 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41166
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18838 Dere\GG17350 Dgri\GH19579 Dmoj\GI23963 Dper\GL21957 Dpse\GA27323 Dsec\GM26236 Dsim\GD20777 Dvir\GJ22515 Dwil\GK13913 Dyak\GE24756
Curated drosophilid orthologs	Dmau\Crc (Tao et al., 2003, Tao et al., 2003) Dmoj\Crc (Schulze et al., 2006) Dpse\GA21781 (Schulze et al., 2006) Dsim\Crc (Tao et al., 2003, Tao et al., 2003) Dvir\Crc (Schulze et al., 2006)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001005-PA Aedes aegypti (mosquito) AGAP004212-PA Anopheles gambiae (mosquito) XP_392689.2 Apis mellifera (honey bee) XP_001952612.1 Acyrthosiphon pisum (pea aphid) At1g56340.1 Arabidopsis thaliana (wall cress) 20750 Batrachochytrium dendrobatidis (chytrid fungus) 115348 Branchiostoma floridae (lancelet) XP_001896170.1 Brugia malayi (roundworm nematode) BGIBMGA000475-PA Bombyx mori (silk worm) ENSBTAP00000020111 Bos taurus (bovine) CN24166 Caenorhabditis brenneri (small nematode) CN27073 Caenorhabditis brenneri (small nematode) CBP02265 Caenorhabditis briggsae (nematode) CE21562 Caenorhabditis elegans (worm) ENSCAFP00000025174 Canis familiaris (dog) ENSCINP00000016510 Ciona intestinalis (sea squirt) JA07020 Caenorhabditis japonica (nematode) CPIJ007376 Culex pipens (mosquito) ENSCPOP00000000708 Cavia porcellus (guinea pig) 78954 Chlamidomonas reinhardtii (green alga) RP12100 Caenorhabditis remanei (nematode) ENSCSAVP00000001554 Ciona savignyi (sedentary tunicate) 21877 Capitella spl (polychaete worm) DDB0191384 Dictyostelium discoideum (amoeba) 210624 Daphnia pulex (daphnia) ENSDARP00000048315 Danio rerio (zebra fish) ENSECAP00000006489 Equus caballus (horse) XP_655241 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014621 Gymnopilus aculeatus (mushroom) ENSGALP00000006222 Gallus gallus (chicken) 122321 Hypsipyla robusta (cedar shoot borer) ENSP00000320866 Homo sapiens (human) ISCW008184-PA Ixodes scapularis (deer tick) 206609 Lottia gigantea (owl limpet) LmjF31.2600 Leishmania major (virus) 20407 Monocosta brevicollis (choanoflagellate) ENSMODP00000014423 Monodelphis domestica (gray opossum) ENSMMUP00000005869 Macaca mulatta (rhesus monkey) ENSMUSP00000003912 Mus musculus (house mouse) 61368 Nematostella vectensis (starlet anemone) XP_001600669.1 Nasonia vitripennis (wasp) ENSOANP00000015541 Ornithorynchus anatinus (platypus) ENSORLP00000003650 Oryzias latipes (japanese killifish) LOC_Os03g61670.1 Oryza sativa (asian rice) PHUM001411-PA Pediculus humanus (human body louse) PP22701 Pristionchus pacificus (nematode) 164102 Physcomitrella patens (moss) ENSPPYP00000010780 Pongo pygmaeus (orangutan) 72214 Phytophthora ramorum (sudden oak death pathogen) 109612 Phytophthora sojae (root rot pathogen) 729432 Populus trichocarpa (black cottonwood) ENSPTRP00000018010 Pan troglodytes (chimpanzee) ENSRNOP00000004091 Rattus norvegicus (norway rat) 4781074 Sorghum bicolor (sorghum) Smp_030370 Schistosoma mansoni (trematode parasite) NP_999643.1 Strongylocentrotus purpuratus (purple sea urchin) 63359 Trichoplax adhaerens (metazoa) Tc00.1047053509011.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510685.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018562 Tetraodon nigroviridis (green spotted pufferfish) 34810 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010934 Takifugu rubripes (pufferfish Takifugu) 84285.m00203 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000017402 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16394 NV19007 LH12180 ISCW008184 FBgn0241859 FBgn0215919 FBgn0209622 FBgn0192241 FBgn0181091 JGI_V11_210624 FBgn0248690 FBgn0159550 FBgn0146687 FBgn0127043 FBgn0109577 FBgn0095855 CPIJ007376 BGIBMGA000475 ACYPI007677 ACYPI002622 GB17282 AGAP004212 AAEL011773 AAEL001005 PHUM046830 GLEAN_12278
Stocks & Reagents
Stocks Listed in FlyBase ( 20 )
Bloomington	13125 w1118; P{GT1}CrcBG02738 21476 y1 w67c23; P{wHy}CrcDG09802 19667 y1 w67c23; P{EPgy2}CrcEY03142 23640 y1 w*; P{UAST-YFP.Rab2.S20N}Crc05
Harvard	- P{XP}Crcd03868 - PBac{WH}Crcf00548
Kyoto	123424 w1118; P{RS3}CrcCB-5036-3 124117 w1118; P{RS3}CrcCB-6470-3 125325 w1118; P{RS5}Crc5-HA-1658 125474 w1118; P{RS5}Crc5-HA-1919 / TM2
VDRC	v51271 w1118; P{GD4328}v51271 v51272 w1118; P{GD4328}v51272
	More stocks available...
Genomic Clones ( 2 )
	BACR19N07 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 313 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE50082
Other clones	DPiM_RE50082
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03429 AT06237 AT06239 AT06267 AT09058 AT17416 AT25770 AT25880 AT28730 GH03325 GH03733 GH05711 GH07360 GH08529 GH08669 GH09450 GH19120 GH22475 GH25160 GH25408 GM01554 GM02452 GM02739 GM02824 GM02903 GM03631 GM03877 GM04836 GM04873 GM05007 GM05391 GM05822 GM09950 GM09992 GM10305 GM12736 GM20550 GM25655 GM25706 LD02180 LD05374 LD07621 LD08080 LD22836 LD25746 LD47611 LP01652 LP01892 LP02225 LP03122 LP03922 LP03931 LP05019 LP06637 LP06829 LP08267 LP08273 LP08610 LP08777 LP09317 LP09520 LP13376 LP13701 LP15586 LP15983 LP16110 LP17408 LP17557 LP18414 LP19487 LP19980 LP20682 LP21333 LP23223 LP23605 LP23907 LP23933 RE03392 RE05431 RE06011 RE06455 RE13758 RE15937 RE16324 RE17455 RE17563 RE19526 RE20372 RE23372 RE24318 RE25720 RE26071 RE29785 RE30052 RE34087 RE36458 RE37944 RE46431 RE46926 RE50085 RE51939 RE54666 RE55131 RE56296 RE56705 RE57352 RE58470 RE58566 RE60137 RE63391 RE65107 RE65551 RE65608 RE66026 RE67489 RE68181 RE69523 RE69547 RE72937 RE73723 RE74978 RH09669 RH48202 RH48872 RH49607 RH65821 RH66088 SD01724 SD02293 SD05385 SD07284 SD11929 SD11957 SD12360 SD12571 SD12730 SD14168 SD14220 SD14720 SD14756 SD16015 SD16265 SD16957 SD17279 SD17316 SD17418 SD17472 SD17983 SD18056 SD18360 SD18501 SD18521 SD18624 SD18733 SD19646 SD19648 SD19720 SD20791 SD21292 SD22255 SD22455 SD23357 SD23404 SD24471 SD25315 SD25980 SD26191 SD26265 SD26621 SD26635 SD26702 SD26875 SD27556 SD28112
Other clones	17665 AA433289 AI124298 AI124304 AT01151 bs80b08 CK01.34C.F12 CK01.87C.D4 CK01334 Dmel_dig_000537_0685_3603 Dmel_dig_008331_0686_2933 Dmel_dig_017003_0580_2656 Dmel_dig_018789_0623_2193 Dmel_neb_001125_0167_0352 Dmel_neb_011457_0099_2035 Dmel_neb_012586_0845_1569 Dmel_neb_015424_0698_2772 EC25046 EC28679 EC31783 EC36660 EK068646 EK069146 EK070230 EK091043 EK094033 EK107826 EK108426 EK112850 EK130018 EK134355 EK180264 EK194617 EK202233 EK231851 EN04554 EN05815 EN08322 EN09303 EN09924 ESG012b.E21.2_G08 ESG015d.E21.1_G12 ESG0113a.B21_H10 ESG0113c.B21.1_G12 FGC027B03 FGH107B08 FGH110A12 FGH118E12 FGH122E04 FGM220A09 FGM224A03 FGM229G12 FGM232D06 FGM235E10 FGM307A10 FGM308G01 FGM325E04 GM02847 GM05871 IP18545 IP18745 RP003003315 RP003003420 RP003017838 RP003024506 RP003040598 RP003050405 RP003051485 RP003060821 RP003066166 RP003075416 RP003075524 RP003076890 RP003078401 RP003081685 RP003082306 RP003088784 RP003112852 RP003115590 RP003121073 RP003130367 RP003154147 RP003163124 RP003169529 RP003174014 RP003194234 RP003199777 RP003200131 RP003206864 RP003208431 RP003211820 RP003216358 RP003220613 RP003222368 RP003227357 RP003244050 RP003244847 RP003247460 RP003258784 RP003259714 RP003263369 RP003269183 RP003295931 RP003297911 RP003300374 RP003308831 RP003313724 RP003374876 RP003379467 RP003386910 RP003408202 RP003415526 RP003421686 RP003433319 RP003439765 RP003441689 RP003452646 RP003454546 RP003500212 RP003509290 RP003516564 RP003522427 RP003545343 RP003549751 RP003557942 RP003569277 RP003574532 RP003590291 RP003602552 RP003614119 RP003614280 RP003617983 RP003627480 RP003632982 RP003638135 RP003652918 RP003660025
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005585 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41166
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Crc anon-EST:fe3D7 (Bayraktaroglu, 2000.11.2) Source for merge of: Crc potp (Prokopenko and Bellen, 2000)
Additional comments
Other Comments
	Gene identified during a P{lacW} screen shown to cause loss of neurons. (Salzberg et al., 1997) Crc gene product shares similarities with other calreticulin proteins. (McCauliffe et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079569 RefSeq (Proteins) • NP_524293 DDBJ / EMBL / GenBank • AA264548 AA433289 AAF54416 AAN71425 AB000718 AF175911 AF175912 AF175913 AF175914 AI124298 AI124304 AI405220 AQ025171 AQ025213 AQ073788 AQ254648 AQ254686 BAA85379 BH615026 BI364890 BT001670 CAA45791 CL610128 CZ483009 X64461 Entrez Gene - A searchable database of RefSeq genes. • 41166 UniProtKB/Swiss-Prot • P29413 UniProtKB/TrEMBL • Q9U916 Q53YH3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Calreticulin/calnexin, conserved site (IPR018124) Calreticulin/calnexin (IPR001580) Concanavalin A-like lectin/glucanase (IPR008985) Calreticulin (IPR009169) Concanavalin A-like lectin/glucanase, subgroup (IPR013320)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66325 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005585 DroID - A comprehensive database of gene and protein interactions. • FBgn0005585 DRSC - Results from RNAi screens. • FBgn0005585 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005585 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9429-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005585 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41166 InParanoid A subset of ortholog calls from InParanoid. • AAEL001005-PA Aedes aegypti (mosquito) AGAP004212-PA Anopheles gambiae (mosquito) XP_392689.2 Apis mellifera (honey bee) XP_001952612.1 Acyrthosiphon pisum (pea aphid) At1g56340.1 Arabidopsis thaliana (wall cress) 20750 Batrachochytrium dendrobatidis (chytrid fungus) 115348 Branchiostoma floridae (lancelet) XP_001896170.1 Brugia malayi (roundworm nematode) BGIBMGA000475-PA Bombyx mori (silk worm) ENSBTAP00000020111 Bos taurus (bovine) CN24166 Caenorhabditis brenneri (small nematode) CN27073 Caenorhabditis brenneri (small nematode) CBP02265 Caenorhabditis briggsae (nematode) CE21562 Caenorhabditis elegans (worm) ENSCAFP00000025174 Canis familiaris (dog) ENSCINP00000016510 Ciona intestinalis (sea squirt) JA07020 Caenorhabditis japonica (nematode) CPIJ007376 Culex pipens (mosquito) ENSCPOP00000000708 Cavia porcellus (guinea pig) 78954 Chlamidomonas reinhardtii (green alga) RP12100 Caenorhabditis remanei (nematode) ENSCSAVP00000001554 Ciona savignyi (sedentary tunicate) 21877 Capitella spl (polychaete worm) DDB0191384 Dictyostelium discoideum (amoeba) 210624 Daphnia pulex (daphnia) ENSDARP00000048315 Danio rerio (zebra fish) ENSECAP00000006489 Equus caballus (horse) XP_655241 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000014621 Gymnopilus aculeatus (mushroom) ENSGALP00000006222 Gallus gallus (chicken) 122321 Hypsipyla robusta (cedar shoot borer) ENSP00000320866 Homo sapiens (human) ISCW008184-PA Ixodes scapularis (deer tick) 206609 Lottia gigantea (owl limpet) LmjF31.2600 Leishmania major (virus) 20407 Monocosta brevicollis (choanoflagellate) ENSMODP00000014423 Monodelphis domestica (gray opossum) ENSMMUP00000005869 Macaca mulatta (rhesus monkey) ENSMUSP00000003912 Mus musculus (house mouse) 61368 Nematostella vectensis (starlet anemone) XP_001600669.1 Nasonia vitripennis (wasp) ENSOANP00000015541 Ornithorynchus anatinus (platypus) ENSORLP00000003650 Oryzias latipes (japanese killifish) LOC_Os03g61670.1 Oryza sativa (asian rice) PHUM001411-PA Pediculus humanus (human body louse) PP22701 Pristionchus pacificus (nematode) 164102 Physcomitrella patens (moss) ENSPPYP00000010780 Pongo pygmaeus (orangutan) 72214 Phytophthora ramorum (sudden oak death pathogen) 109612 Phytophthora sojae (root rot pathogen) 729432 Populus trichocarpa (black cottonwood) ENSPTRP00000018010 Pan troglodytes (chimpanzee) ENSRNOP00000004091 Rattus norvegicus (norway rat) 4781074 Sorghum bicolor (sorghum) Smp_030370 Schistosoma mansoni (trematode parasite) NP_999643.1 Strongylocentrotus purpuratus (purple sea urchin) 63359 Trichoplax adhaerens (metazoa) Tc00.1047053509011.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510685.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018562 Tetraodon nigroviridis (green spotted pufferfish) 34810 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010934 Takifugu rubripes (pufferfish Takifugu) 84285.m00203 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000017402 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41166 modMine - Data generated by the modENCODE project. • FBgn0005585 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16394 NV19007 LH12180 ISCW008184 FBgn0241859 FBgn0215919 FBgn0209622 FBgn0192241 FBgn0181091 JGI_V11_210624 FBgn0248690 FBgn0159550 FBgn0146687 FBgn0127043 FBgn0109577 FBgn0095855 CPIJ007376 BGIBMGA000475 ACYPI007677 ACYPI002622 GB17282 AGAP004212 AAEL011773 AAEL001005 PHUM046830 GLEAN_12278
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-EST:fe3D7   anon-EST:Liang-2.11   anon-EST:Liang-2.17   CG9429 (Khokhar et al., 2008, Norga et al., 2003, Stempfl et al., 2002, Quinones-Coello, 2007, Kondylis et al., 2011, Walker et al., 2006, Cammarato et al., 2011) clone 2.11 (Liang and Biggin, 1998) clone 2.17 (Liang and Biggin, 1998) Clr (Christodoulou et al., 1997) Crc (Khokhar et al., 2008, Farkas et al., 2007, Beller et al., 2006, Stuart et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Gilchrist et al., 2010, Zhang et al., 2007, Farkas et al., 2008, Carbone et al., 2009, Yamamoto et al., 2008, Weake et al., 2009, Kuraishi et al., 2009, Lighthouse et al., 2008, Tolhuis et al., 2011, Neumüller et al., 2011) crc (Gamo et al., 2003) eth (Dodo et al., 1995) potp (Prokopenko et al., 2000, Prokopenko and Bellen, 2000, Prokopenko, 1999.8.5, Prokopenko, 1999.8.5, Bloomington Drosophila Stock Center, 1998.6.3, Salzberg et al., 1997, ) unnamed (Schmid and Tautz, 1997)
Name Synonym	anon-fast-evolving-3D7   calreticulin (Khokhar et al., 2008, Smith, 1992.2.17, Kang et al., 2002, Gamo, 1997.1.26, Christodoulou et al., 1997, Kuraishi et al., 2009, Walker et al., 2006) Calreticulin (Harbison and Sehgal, 2008, Sambandan et al., 2008, Sambandan et al., 2006, Yamamoto et al., 2008, Jayaram et al., 2008, Lighthouse et al., 2008, Gamo et al., 2003, Kondylis et al., 2011, Tolhuis et al., 2011, Cammarato et al., 2011) potpourri (Dilda and Mackay, 2002) pot pourri (Salzberg et al., 1997)
Secondary FlyBase IDs
	FBgn0022988 FBgn0025188
References ( 80 )
Generate a list of	All references relating to this gene ( 80 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 7 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 8 )
	Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Dottorini et al., 2011, BMC Bioinformatics 12: 34 Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. [FBrf0214379] Kondylis et al., 2011, PLoS ONE 6(2): e17173 Identification of ER Proteins Involved in the Functional Organisation of the Early Secretory Pathway in Drosophila Cells by a Targeted RNAi Screen. [FBrf0213167] Morozova et al., 2011, Genetics 187(4): 1193--1205 Transcriptional networks for alcohol sensitivity in Drosophila melanogaster. [FBrf0214377] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Tolhuis et al., 2011, PLoS Genet. 7(3): e1001343 Interactions among Polycomb Domains Are Guided by Chromosome Architecture. [FBrf0213356] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Gilchrist et al., 2010, Cell 143(4): 540--551 Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. [FBrf0214290] Show all research papers ...