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Gene Dmel\btl

General Information
Symbol	Dmel\btl	Species	D. melanogaster
Name	breathless	Annotation symbol	CG32134
Feature type	protein_coding_gene	FlyBase ID	FBgn0005592
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	dev, FGFR, DFR2, DFGF-R1, dtk2, DmHD-311, FGFR1, Fgf-r
Genomic Location
Chromosome (arm)	3L	Recombination map	3-40.9
Cytogenetic map	70D2-70D2	Sequence location	3L:14,068,872..14,075,985 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene breathless is referred to in FlyBase by the symbol Dmel\btl (CG32134, FBgn0005592). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: fibroblast growth factor-activated receptor activity. There is experimental evidence for 14 unique biological process terms, many of which group under: anatomical structure development; open tracheal system development; morphogenesis of a branching epithelium; localization; biological regulation; cellular component organization or biogenesis; locomotion; cellular process involved in reproduction; epithelial cell type specification, open tracheal system; regulation of kinase activity; genital disc development; cellular component movement; microspike assembly; regulation of multicellular organismal development. 53 alleles are reported. The phenotypes of these alleles are annotated with: organ system; primordium; late extended germ band embryo; embryonic/larval tracheal system; tracheal system; portion of tissue; tracheal branch primordium; non-connected developing system; cell part; embryonic/larval dorsal branch; dorsal trunk primordium; dorsal branch primordium; organ system subdivision; cell projection; ganglionic branch primordium. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; Tyrosine-protein kinase, fibroblast growth factor receptor-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1640670_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of btl. Gene sequence location is 3L:14068872..14075985.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	dev: devenir Isolated as a dominant suppressor of Pc mutations. Associated with recessive larval lethality. Lowered survival and loss of humeral bristles in combination with D3 may indicate allelism with Dichaete, but it is difficult to ascertain.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Jones and Metzstein, 2011, Genetics 189(1): 153--164 Marco et al., 2009, Bioinformatics 25(19): 2473--2477 Controlled Vocabulary Terms branching involved in open tracheal system development
FB2012_01	References Zhan et al., 2010, PLoS ONE 5(11): e14134 Controlled Vocabulary Terms activation of MAPK activity border follicle cell migration Transgenic Constructs P{btl-GAL80.M} Sequence features BKN20427 BKN50651 HFA11331 BKN51043
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 70D2-70D2   Limits computationally determined from genome sequence between P{PZ}l(3)70Da02402&P{PZ}btl00208 and P{PZ}Mpcp00564
Experimentally Determined Cytological Location
Cytogenetic map Notes References 70D1-70D2   (determined by in situ hybridisation) 70D1 (determined by in situ hybridisation)   (Burmester et al., 2000) 70D1-70D2   (determined by in situ hybridisation)   (Spradling et al., 1999) 70D1-70D2   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 70D1-70D2   (determined by in situ hybridisation)   (Deak et al., 1997) 70D1-70D2     (BDGP Project Members, 1994-1999) 70C-70C   (determined by in situ hybridisation)   (Shishido et al., 1993) 70C-70C   (determined by in situ hybridisation)   (Glazer and Shilo, 1991)
Experimentally Determined Recombination Data
Location	3-40.9   3-41 (Kennison and Tamkun, 1988)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\btl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	EST evidence indicates that 5' UTR overlaps 3' UTR of upstream gene; (based upon 5' extent of LD22315 ).
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) btl-RA FBtr0075778  NM_168577   3561   1052 btl-RB FBtr0100676  NM_001014583   3409   1052
Additional Transcript Data & Comments
Reported size (kB)	4.3 (northern blot) (Glazer and Shilo, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein btl-PA   FBpp0075520   117.8   1052   6.20     NP_729956   AAF49759 btl-PB   FBpp0100143   117.8   1052   6.20     NP_001014583   AAX52746
Additional Polypeptide Data & Comments
Reported size (kDa)	1052 (aa) (Shishido et al., 1993) 1051 (aa) (Klambt et al., 1992) 140 (kD) (Doctor et al., 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, fibroblast growth factor receptor-related (IPR020732) Immunoglobulin-like fold (IPR013783) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49759   AE014296 AAX52746   AB002696   AJ002918 CAA05753   AQ026309   AQ034129   BT100130   BZ665560   CO299356   CO303350   CO313410   EC076630   EC199712   EC201836   EC248973   G00614   S55971 AAB19904   X57746 CAA40912   X72830 CAA51340   X74031 CAA52190
UniProtKB/Swiss-Prot	Q09147
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000160714 3L:14,072,214..14,072,226 bound_moiety=vvl-XP evidence=experimental (Anderson et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160715 3L:14,072,344..14,072,373 bound_moiety=slbo-XP evidence=experimental (Bergman et al., 2004, Murphy et al., 1995) protein binding site FBsf0000160716 3L:14,071,199..14,071,213 bound_moiety=vvl-XP evidence=experimental (Bergman et al., 2004, Anderson et al., 1996) protein binding site FBsf0000160717 3L:14,071,770..14,071,786 evidence=experimental bound_moiety=vvl-XP (Bergman et al., 2004, Anderson et al., 1996) protein binding site FBsf0000160718 3L:14,070,440..14,070,451 bound_moiety=slbo-XP evidence=experimental (Bergman et al., 2004, Murphy et al., 1995) protein binding site FBsf0000160719 3L:14,072,255..14,072,288 bound_moiety=slbo-XP evidence=experimental (Murphy et al., 1995, Bergman et al., 2004) protein binding site FBsf0000160720 3L:14,072,388..14,072,407 bound_moiety=slbo-XP evidence=experimental (Murphy et al., 1995, Bergman et al., 2004) protein binding site FBsf0000160721 3L:14,071,671..14,071,700 bound_moiety=vvl-XP evidence=experimental (Anderson et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160722 3L:14,071,747..14,071,758 bound_moiety=vvl-XP evidence=experimental (Bergman et al., 2004, Anderson et al., 1996) protein binding site FBsf0000160723 3L:14,071,222..14,071,244 bound_moiety=vvl-XP evidence=experimental (Anderson et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160724 3L:14,072,299..14,072,312 bound_moiety=slbo-XP evidence=experimental (Murphy et al., 1995, Bergman et al., 2004) protein binding site FBsf0000160725 3L:14,072,157..14,072,175 bound_moiety=slbo-XP evidence=experimental (Murphy et al., 1995, Bergman et al., 2004) protein binding site FBsf0000160726 3L:14,070,203..14,070,214 bound_moiety=slbo-XP evidence=experimental (Murphy et al., 1995, Bergman et al., 2004) protein binding site FBsf0000160727 3L:14,072,154..14,072,170 bound_moiety=vvl-XP evidence=experimental (Anderson et al., 1996, Bergman et al., 2004) protein binding site FBsf0000160728 3L:14,070,171..14,070,183 bound_moiety=slbo-XP evidence=experimental (Murphy et al., 1995, Bergman et al., 2004) protein binding site FBsf0000160729 3L:14,071,812..14,071,823 bound_moiety=vvl-XP evidence=experimental (Anderson et al., 1996, Bergman et al., 2004)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   tracheal pit   (Glazer and Shilo, 1991) embryonic stage 12   VUM neuron   (Klambt et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral midline   (Klambt et al., 1992) embryonic stage 6 -- 8   posterior midgut primordium   (Shishido et al., 1993) anterior midgut primordium   (Shishido et al., 1993) embryonic stage 6 -- 17   ventral midline   (Klambt et al., 1992) embryonic stage 8 -- 17   ventral midline   (Shishido et al., 1993) embryonic stage 10   tracheal primordium   (Ohshiro and Saigo, 1997) embryonic stage 10 -- 17   tracheal pit   (Shishido et al., 1993) embryonic/larval tracheal system   (Ohshiro and Saigo, 1997) tracheal primordium   (Ohshiro and Saigo, 1997) embryonic stage 11   tracheal primordium   (Jin et al., 2001, Glazer and Shilo, 1991) embryonic stage 11 -- 12   tracheal pit   (Ohshiro and Saigo, 1997) embryonic stage 12   midline glial cell   (Klambt et al., 1992) embryonic stage 12 -- 14   dorsal trunk anterior branch   (Ohshiro and Saigo, 1997) dorsal trunk posterior branch   (Ohshiro and Saigo, 1997) embryonic/larval transverse connective   (Ohshiro and Saigo, 1997) embryonic stage 13 -- 14   embryonic/larval dorsal trunk   (Ohshiro and Saigo, 1997) lateral trunk anterior branch   (Ohshiro and Saigo, 1997) lateral trunk posterior branch   (Ohshiro and Saigo, 1997) dorsal branch   (Ohshiro and Saigo, 1997) embryonic stage 13 -- 17   embryonic/larval salivary gland   (Shishido et al., 1993) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage   organism   (Glazer and Shilo, 1991) Comment:expression is lower in adults than earlier stages
Additional Descriptive Data
	Transcript is detected in the 10 ectodermal placodes that specify the trachea. Expression begins a short time after the trh protein is first detected in this region. (Jin et al., 2001) btl expression is first observed in the anterior and posterior midgut primordia at the beginning of germ band extension. The expression becomes more prominent when the midguts invaginate. At stage 8, expression is observed along the ventral midline. By stage 10, expression is observed in cells contributing to tracheal pit formation. Finally, at stage 13, btl expression is observed in cells corresponding to presumptive salivary ducts and salivary tubes. (Shishido et al., 1993) btl expression is detected just before the onset of gastrulation at stage 5 at the posterior pole and in two groups of ventral cells at the anterior tip of the embryo. During gastrulation, btl expression is detected in the mesectodermal precursor cells as they migrate toward the midline, where they meet to form the midline precursor cells. Expression continues in the midline cells and becomes modulated in a segmental manner. During stage 12, btl expression is most pronounced in the midline cells in the posterior half of each segment. This includes the VUM neurons and the posterior pair of midline glial cells. (Klambt et al., 1992) btl transcripts are expressed throughout development with maximal levels in 0-12hr embryos. They are detected in the cells surrounding the developing tracheal pits in germ band extended embryos. (Glazer and Shilo, 1991) Expression in the midline and tracheal pits was observed at about 10% of wild type levels. (Klambt et al., 1992) Only trace amounts of btl transcripts are detected. (Klambt et al., 1992) btl transcripts first become detectable in tracheal placodes at stage 10 and reach maximal levels by stage 11. At stage 12, six major buds grow out in different directions. It was observed that transverse connectives and primary branches not giving off secondary and terminal branches lose btl expression at earlier stages while primary branches from which secondary and terminal branches are given off appear to continue to express btl until later stages. (Ohshiro and Saigo, 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval trachea   (Glazer and Shilo, 1991) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   ventral midline   (Glazer and Shilo, 1991) tracheal pit   (Glazer and Shilo, 1991) embryonic stage 10 -- 11   tracheal primordium   • plasma membrane (Glazer and Shilo, 1991) embryonic stage 11   ventral midline   • plasma membrane (Glazer and Shilo, 1991) embryonic stage 12 -- 14   tracheal pit   • plasma membrane (Glazer and Shilo, 1991) presumptive embryonic/larval tracheal system   • plasma membrane (Glazer and Shilo, 1991)
Additional Descriptive Data
	The btl protein is localized to tracheal placodes which form the tracheal pits. It is later seen along the entire developing tracheal tree. btl protein is also found on the delaminating neuronal and glial precursors of the midline and in the cells opposite the clypeolabrum in the stomodeal opening. (Glazer and Shilo, 1991)
Marker for
Subcellular Localization
CV Term	plasma membrane (Glazer and Shilo, 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0005592    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0005592 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0005592 expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr    2048 embryo 06-08hr    2987 embryo 08-10hr    1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr  (481) embryo 04-06hr  (2048) embryo 06-08hr  (2987) embryo 08-10hr  (1890) embryo 10-12hr  (1221) embryo 12-14hr  (700) embryo 14-16hr  (383) embryo 16-18hr  (454) embryo 18-20hr  (286) embryo 20-22hr  (171) embryo 22-24hr  (193) larva L1  (229) larva L2  (316) larva L3 12hr old  (267) larva L3 puffstage 1-2  (156) larva L3 puffstage 3-6  (213) larva L3 puffstage 7-9  (324) white prepupae new  (353) white prepupae 12hr  (282) white prepupae 24hr  (255) pupae 2d postWPP  (292) pupae 3d postWPP  (650) pupae 4d postWPP  (180) adult male 01day  (224) adult male 05day  (176) adult male 30day  (145) adult female 01day  (159) adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr  (2048) embryo 06-08hr  (2987) embryo 08-10hr  (1890) embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr    2048 embryo 06-08hr    2987 embryo 08-10hr    1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr    2048 embryo 06-08hr    2987 embryo 08-10hr    1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0005592 expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr    2048 embryo 06-08hr    2987 embryo 08-10hr    1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr  (481) embryo 04-06hr  (2048) embryo 06-08hr  (2987) embryo 08-10hr  (1890) embryo 10-12hr  (1221) embryo 12-14hr  (700) embryo 14-16hr  (383) embryo 16-18hr  (454) embryo 18-20hr  (286) embryo 20-22hr  (171) embryo 22-24hr  (193) larva L1  (229) larva L2  (316) larva L3 12hr old  (267) larva L3 puffstage 1-2  (156) larva L3 puffstage 3-6  (213) larva L3 puffstage 7-9  (324) white prepupae new  (353) white prepupae 12hr  (282) white prepupae 24hr  (255) pupae 2d postWPP  (292) pupae 3d postWPP  (650) pupae 4d postWPP  (180) adult male 01day  (224) adult male 05day  (176) adult male 30day  (145) adult female 01day  (159) adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr  2048 embryo 06-08hr  (2987) embryo 08-10hr  1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr    2048 embryo 06-08hr    2987 embryo 08-10hr    1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    481 embryo 04-06hr    2048 embryo 06-08hr    2987 embryo 08-10hr    1890 embryo 10-12hr    1221 embryo 12-14hr    700 embryo 14-16hr    383 embryo 16-18hr    454 embryo 18-20hr    286 embryo 20-22hr    171 embryo 22-24hr    193 larva L1    229 larva L2    316 larva L3 12hr old    267 larva L3 puffstage 1-2    156 larva L3 puffstage 3-6    213 larva L3 puffstage 7-9    324 white prepupae new    353 white prepupae 12hr    282 white prepupae 24hr    255 pupae 2d postWPP    292 pupae 3d postWPP    650 pupae 4d postWPP    180 adult male 01day    224 adult male 05day    176 adult male 30day    145 adult female 01day    159 adult female 05day    73 adult female 30day    70 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0005592    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0005592 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0005592 expression level Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0005592 expression level Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.575 Larval Midgut    2.3 Larval Hindgut    7.4 Larval Malpighian Tubules    3.2 Larval Fat Body    2.2 Larval Salivary Gland    1.2 Larval Trachea    223.05 Larval Carcass    8.25 Adult Head no informative data Adult Eye    2.1 Adult Brain    1.2 Adult Thoracic-Abdominal Ganglion    1.7 Adult Crop    70.8 Adult Midgut    9.4 Adult Hindgut    56.3 Adult Malpighian Tubules    2.9 Adult Fat Body    2.6 Adult Salivary Gland    4 Adult Heart    9.85 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    73.5 Adult Ovary    0.7 Adult Testis    0.7 Adult Male Accessory Gland    2.9 Adult Carcass    2.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    2.1   NA  Brain    1.2   2.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.7   NA  Crop    70.8   2.3  Midgut    9.4   7.4  Hindgut    56.3   3.2  Malpighian Tubules    2.9   2.2  Fat Body    2.6   1.2  Salivary Gland    4   NA  Heart    9.85   223.05  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    73.5   NA  Ovary    0.7   NA  Testis    0.7   NA  Male Accessory Gland    2.9   8.25  Carcass    2.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005592 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32134-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal btl724 btl788 btl1118 btl1187 btl1476 btl1684 lethal (with Df(3L)fz-GF3b) btlS084401 lethal | embryonic stage | recessive btl00208 btlLG18 btlLG19 btlS084401 lethal | recessive btl6-81Δ1 btl00208 btldev1 btldev2 btlH82Δ3 btlH82Δ11 btlLG18 btlLG19 btlS084401 btlΔOh10 btlΔOh17 btlΔOh35-1 viable btl6-81 viable, with Scer\GAL4pnr-MD237 btlGD85 btlGD2581 btlGD14439 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4ato.3.6 btlDN.Scer\UAS btlScer\UAS.cDa neuroanatomy defective, with Scer\GAL4hs.2sev btlDN.Scer\UAS wild-type btlABP btlhs.PM btlN-14 Phenotype manifest in Allele air sac tracheoblast of dorsal air sac primordium btlKR.hs air sac tracheoblast of dorsal air sac primordium, with Scer\GAL4btl.PS btlDN.Scer\UAS btlScer\UAS.T:λ\cI-DD air sac tracheoblast of dorsal mesothoracic disc & filopodium btlKR.hs btlhs.T:λ\cI-DD axon & dorsal cluster neuron, with Scer\GAL4ato.3.6 btlScer\UAS.cDa axon & dorsal cluster neuron & adult brain, with Scer\GAL4ato.3.6 btlDN.Scer\UAS chorion, with Scer\GAL4CY2 btlScer\UAS.T:λ\cI-DD coiled tracheole, with Scer\GAL4btl.PS btlDN.Scer\UAS coiled tracheole | ectopic, with Scer\GAL4btl.PS btlScer\UAS.T:λ\cI-DD denticle belt, with Scer\GAL4CY2 btlScer\UAS.T:λ\cI-DD dorsal air sac primordium btlH82Δ3 dorsal air sac primordium | somatic clone btlH82Δ3 btlLG18 dorsal branch primordium btl95 btlH82Δ3 dorsal trunk primordium btlH82Δ11 embryo, with Scer\GAL4CY2 btlScer\UAS.T:λ\cI-DD embryonic/larval dorsal branch (with btl724) btlBN embryonic/larval dorsal branch (with btlBN) btl724 embryonic/larval dorsal branch & terminal tracheal cell | somatic clone btl724 embryonic/larval dorsal trunk btlH82Δ3 embryonic/larval ganglionic branch, with Scer\GAL4A9 btlDN.Scer\UAS embryonic/larval muscle system btlLG19 embryonic/larval trachea btlΔOh10 embryonic/larval trachea, with Scer\GAL4A9 btlDN.Scer\UAS embryonic/larval trachea, with Scer\GAL4bs-23.26 btlDN.Scer\UAS embryonic/larval tracheal system btlΔOh10 btlΔOh17 btlΔOh35-1 btl6-81Δ1 btl6-81 btlH82Δ11 btlH82Δ3 btlKR.hs btlLG18 btlLG19 btlhs.T:λ\cI-DD embryonic/larval tracheal system, with Scer\GAL4hs.2sev btlDN.Scer\UAS embryonic/larval tracheal system, with Scer\GAL4tracheal btlScer\UAS.T:λ\cI-DD embryonic/larval tracheal system (with btlH82Δ3) btlLG19 embryonic/larval tracheal system (with btlLG19) btlH82Δ3 embryonic tracheal system & filopodium btlH82Δ3 filopodium btlMtnA.T:Avic\GFP-S65T ganglionic branch primordium btlH82Δ11 lateral G branch, with Scer\GAL4bs-23.26 btlDN.Scer\UAS lateral trunk anterior branch btl95 midline glial cell, with Scer\GAL4hs.2sev btlDN.Scer\UAS presumptive embryonic/larval tracheal system btl1928 btl469 btlH82Δ11 btlH82Δ3 btlLG19 btlMZ13 presumptive embryonic/larval tracheal system (with btl95) btlH82Δ11 btlLG19 presumptive embryonic/larval tracheal system (with btlH82Δ11) btl95 presumptive embryonic/larval tracheal system (with btlLG19) btl95 presumptive embryonic/larval tracheal system (with Df(3L)fz-GF3b) btl95 pupal tracheal system, with Scer\GAL4btl.PS btlDN.Scer\UAS btlScer\UAS.T:λ\cI-DD terminal tracheal cell btlBN terminal tracheal cell, with Scer\GAL4btl.PS btlScer\UAS.T:λ\cI-DD terminal tracheal cell | somatic clone btl724 btl788 btl1684 btl1476 btl1118 btl1187 tracheal branch primordium btlH82Δ11 tracheal branch primordium, with Scer\GAL4btl.PS btlDN.Scer\UAS tracheal pit btlLG19 tracheal primordium btlLG19 tracheal tip cell & filopodium btlH82Δ3 visceral branch primordium btlH82Δ11
Classical Alleles ( 36 )
For All Classical Alleles Show
Allele of btl Class Mutagen Stocks Known lesion btldev1 hypomorphic allele - genetic evidence ethyl methanesulfonate 2 -- btlEY01638 P-element activity 2 -- btlCB-0322-3 1 -- btld11372 1 -- btlDG12208 P-element activity 1 -- btlf02864 1 -- btlMI03286 1 -- btlNP6593 1 -- btlH82Δ3 loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence Delta2-3 0 Yes btlLG18 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- btlLG19 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- btl00208 P-element activity 0 Yes btl04727 P-element activity 0 -- btl1118 loss of function allele ethyl methanesulfonate 0 Yes btl1187 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes btl1476 loss of function allele ethyl methanesulfonate 0 Yes btl1684 loss of function allele ethyl methanesulfonate 0 Yes btl1928 ethyl methanesulfonate 0 -- btl1 0 -- btl469 loss of function allele ethyl methanesulfonate 0 Yes btl6-81 P-element activity 0 Yes btl6-81Δ1 hypomorphic allele - genetic evidence Delta2-3 0 Yes btl724 loss of function allele ethyl methanesulfonate 0 Yes btl788 loss of function allele ethyl methanesulfonate 0 Yes btl95 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes btlBN 0 Yes btldev2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- btlH82Δ11 hypomorphic allele - genetic evidence Delta2-3 0 Yes btlH852-3 0 -- btlMZ13 0 -- btlS084401 Delta2-3 P-element activity 0 Yes btlunspecified 0 -- btlΔ10 loss of function allele 0 -- btlΔOh10 P-element activity 0 Yes btlΔOh17 P-element activity 0 Yes btlΔOh35-1 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of btl Class Mutagen Stocks Known lesion btlGD85 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes btlGD14439 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes btlhs.T:λ\cI-DD in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes btlScer\UAS.T:λ\cI-DD in vitro construct - regulatory fusion 2 Yes btlABP in vitro construct 0 Yes btlactiv.Scer\UAS in vitro construct - regulatory fusion 0 Yes btlDN.Scer\UAS antimorphic allele - genetic evidence in vitro construct - regulatory fusion 0 Yes btlGD2581 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes btlhs.PM in vitro construct - regulatory fusion 0 Yes btlKK100331 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes btlKR.hs antimorphic allele - genetic evidence in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes btlMtnA.T:Avic\GFP-S65T in vitro construct - regulatory fusion 0 Yes btlN-14 in vitro construct - genomic fragment 0 Yes btlScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes btlScer\UAS.cKa in vitro construct - regulatory fusion 0 Yes btlScer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes btlT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)D-1rv16 (Burmester et al., 2000, Carpenter, 1994, Russell et al., 1996) Df(3L)D-5rv5 (Carpenter, 1994) Df(3L)D-5rv6 (Burmester et al., 2000, Carpenter, 1994, Russell et al., 1996) Df(3L)D-5rv12 (Carpenter, 1994) Df(3L)D-5rv14 (Carpenter, 1994) Df(3L)Exel6120 (Ryder, 2004.4.26) Df(3L)fz-CAL5 (Netter et al., 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3L)fz-D21 (Netter et al., 1998, Burmester et al., 2000, Carpenter, 1994) Df(3L)fz-GF3b (Szeged Stock Center, 1998-, Burmester et al., 2000, Klambt et al., 1992, Giniger et al., 1993, Carpenter, 1994, Deak et al., 1997) Df(3L)fz-GS1a (Spradling et al., 1999, Burmester et al., 2000, Klambt et al., 1992, Giniger et al., 1993, BDGP Project Members, 1994-1999, Carpenter, 1994, Russell et al., 1996) Df(3L)J40 (Burmester et al., 2000)
Not disrupted in	Df(3L)D4rv42 (Carpenter, 1994) Df(3L)fz-M21 (Szeged Stock Center, 1998-, Burmester et al., 2000, Carpenter, 1994) In(3L)D4rv32 (Carpenter, 1994) In(3LR)D4rv37 (Carpenter, 1994) T(2;3)D4rv38 (Carpenter, 1994) T(Y;2;3)D4rv33 (Carpenter, 1994) Tp(3;?)D-4rv40 (Carpenter, 1994)
Not duplicated in	Ts(YSt;3Lt)ST1 (Brizuela et al., 1994)
Duplicated in	Dp(3;3)D4rv36 (Carpenter, 1994)
Partially disrupted in	Df(3L)D-4rv34 (Carpenter, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{btl-lacZ.ABP} No P{btl-lacZ.ABPC} No P{btl-lacZ.B1} No P{btl-lacZ.B3.M2} No P{btl-lacZ.B3} No P{btl-lacZ.B4} No P{btl-lacZ.B23} No P{btl-lacZ.B123} No P{btl-lacZ.B'PC} No P{btl-lacZ.BPC} No P{btl-lacZ.mut3} No P{btl-lacZ.mut23} No P{btl-lacZ.mut123} No P{btl-lacZ.P} No P{btl-lacZ.P+} No P{btl-lacZ.P+C} No UAS construct P{DN-R1} NA P{GD85} NA P{GD2581} NA P{GD14439} NA P{KK100331} NA P{UAS-btl::GFP-S65T} NA P{UAS-btl.activ} NA P{UAS-btl.D} NA P{UAS-btl.K} NA P{UAS-btl.λ} NA heat-shock construct P{hs-btl.M} NA P{hs-btlK->R} NA P{hs-λbtl} NA characterization construct P{btl.ABP} NA P{btl.N-14} NA P{btl-GAL80.M} NA P{hs-λtop} NA P{sE-tor4021-btl} NA P{UAS-btl::Egfr.D} NA P{UAS-btl::htl.BH} NA P{UAS-btl::htl.HB} NA P{UAS-btl::tor.D} NA P{UAS-Egfr.λtop} NA P{UAS-torso4021-btl} NA P{UAS-λ-Egfr.Y1095F} NA P{UAS-λ-Egfr.Y1095F-Y1342F} NA P{UAS-λ-Egfr.Y1204F} NA P{UAS-λ-Egfr.Y1218F} NA P{UAS-λ-Egfr.Y1246F} NA P{UAS-λ-Egfr.Y1271F} NA P{UAS-λ-Egfr.Y1310F} NA P{UAS-λ-Egfr.Y1342F} NA P{UAS-λ-Egfr.Y1357} NA P{UAS-λ-Egfr.Y1357F.Y1405F.Y1406F} NA P{UAS-λ-Egfr.Y1357F} NA P{UAS-λ-Egfr.Y1405F.Y1406F} NA P{UAS-λ-Egfr.YFall} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}btl6-81 No P{lacW}btlS084401 No P{lacW}l(3)j2E11j2E11 No P{lacZ}Tracheal-2 No P{lwB}H82 No P{PZ}btl00208 No P{PZ}btl04727 No miscellaneous insertions Mi{MIC}btlMI03286 NA P{5'lacW}btl6-81Δ1 NA P{5'lwB}btlH82Δ3 NA P{5'lwB}btlH82Δ11 NA P{?lacW}btlΔOh10 NA P{?lacW}btlΔOh17 NA P{RS3}btlCB-0322-3 NA P{wHy}btlDG12208 NA PBac{WH}btlf02864 NA insertion of mobile activating element P{EPgy2}btlEY01638 NA P{XP}btld11372 NA insertion of enhancer trap binary system P{GawB}btlNP6593 No
Gene Ontology: Function, Process & Cellular Component ( 26 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
activation of MAPK activity inferred from expression pattern (Ohshiro et al., 2002) border follicle cell migration inferred from mutant phenotype (Murphy et al., 1995) branching involved in open tracheal system development inferred from mutant phenotype (Jones and Metzstein, 2011) epithelial cell migration, open tracheal system inferred from mutant phenotype (Glazer and Shilo, 1991, Klambt et al., 1992, Reichman-Fried and Shilo, 1995, Lee et al., 1996, Hsouna et al., 2010) epithelial cell type specification, open tracheal system inferred from mutant phenotype (Ghabrial and Krasnow, 2006) filopodium assembly inferred from mutant phenotype (Ribeiro et al., 2002) genital disc development inferred from expression pattern (Ahmad and Baker, 2002) glial cell migration inferred from mutant phenotype (Klambt et al., 1992) negative regulation of axon extension inferred from mutant phenotype (Srahna et al., 2006) open tracheal system development inferred from expression pattern (Glazer and Shilo, 1991) primary branching, open tracheal system inferred from mutant phenotype (Samakovlis et al., 1996, Lee et al., 1996, Myat et al., 2005, Cela and Llimargas, 2006) secondary branching, open tracheal system inferred from mutant phenotype (Samakovlis et al., 1996, Lee et al., 1996) terminal branching, open tracheal system inferred from mutant phenotype (Reichman-Fried and Shilo, 1995, Lee et al., 1996) tracheal outgrowth, open tracheal system inferred from mutant phenotype (Ribeiro et al., 2002, Cabernard and Affolter, 2005)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 17 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) fibroblast growth factor-activated receptor activity inferred from sequence or structural similarity (Shishido et al., 1991) inferred from sequence or structural similarity with mouse Fgfr1 (Glazer and Shilo, 1991) traceable author statement (Bier, 1998, Affolter, 2000, Wilson and Leptin, 2000, Ghabrial et al., 2003, Itoh and Ornitz, 2004) protein tyrosine kinase activity non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000, Swiss-Prot Project Members, 1995.6.1)
Biological Process
CV term Evidence References
central nervous system development non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) endoderm development non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) epithelial cell migration, open tracheal system traceable author statement (Zelzer and Shilo, 2000, Affolter, 2000, Rosin and Shilo, 2002, Nelson, 2003) fibroblast growth factor receptor signaling pathway non-traceable author statement (Rosin and Shilo, 2002) traceable author statement (Bier, 1998, Affolter, 2000, Ghabrial et al., 2003) mesoderm development non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) morphogenesis of a branching structure traceable author statement (Affolter and Shilo, 2000) muscle organ development non-traceable author statement (Swiss-Prot Project Members, 1995.6.1) open tracheal system development non-traceable author statement (Bier, 1998, Affolter and Shilo, 2000) traceable author statement (Wilson and Leptin, 2000, Bradley et al., 2001, Ribeiro et al., 2003) primary branching, open tracheal system traceable author statement (Uv et al., 2003, Ghabrial et al., 2003) protein phosphorylation non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1995.6.1) salivary gland morphogenesis non-traceable author statement (Bradley et al., 2001) secondary branching, open tracheal system traceable author statement (Ghabrial et al., 2003) terminal branching, open tracheal system traceable author statement (Zelzer and Shilo, 2000)
Cellular Component
CV term Evidence References
plasma membrane inferred by curator from GO:0005007 (Glazer and Shilo, 1991) inferred from sequence or structural similarity (Shishido et al., 1991) inferred from sequence or structural similarity with human FGFR1 (Shishido et al., 1993) non-traceable author statement (Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions btl allele Gene References btl1 CycE (Brumby et al., 2002) btl00208 CycE (Brumby et al., 2002) sev (Maixner et al., 1998) btl04727 sev (Maixner et al., 1998) btldev1 Pc (Kennison and Tamkun, 1988, Lindsley and Zimm, 1992) btldev2 Pc (Kennison and Tamkun, 1988, Lindsley and Zimm, 1992) btlH82Δ3 awd (Dammai et al., 2003) jing (Sedaghat et al., 2002) slbo (Murphy et al., 1995) stumps (Michelson et al., 1998) trh (Sedaghat et al., 2002) btlhs.PM slbo (Murphy et al., 1995) vvl (Llimargas and Casanova, 1997) btlLG19 bnl (Sutherland et al., 1996) phl::tor (Vincent et al., 1998) Ras85D (Vincent et al., 1998) slbo (Murphy et al., 1995) btlScer\UAS.T:Avic\GFP-S65T awd (Dammai et al., 2003) unspecified bsk (Srahna et al., 2006) hep (Srahna et al., 2006) kni (Myat et al., 2005) knrl (Myat et al., 2005) Mkp3 (Cela and Llimargas, 2006) ph-p (Fauvarque et al., 1995) put (Myat et al., 2005) Rac1 (Srahna et al., 2006) sli (Sedaghat et al., 2002) tgo (Sedaghat et al., 2002) tkv (Myat et al., 2005) trimmed (Shim et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64900 DroID - A comprehensive database of gene and protein interactions. • FBgn0005592 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39564
Orthologs
Genome-wide drosophilid orthologs	Dere\GG15673 Dsec\GM25453 Dwil\GK17039 Dyak\GE22002
Curated drosophilid orthologs	Dana\btl
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002172-PA Aedes aegypti (mosquito) AGAP003108-PA Anopheles gambiae (mosquito) BGIBMGA010090-PA Bombyx mori (silk worm) ENSBTAP00000009427 Bos taurus (bovine) ENSBTAP00000018708 Bos taurus (bovine) ENSCAFP00000018223 Canis familiaris (dog) ENSCAFP00000024312 Canis familiaris (dog) 300042 Daphnia pulex (daphnia) ENSDARP00000011898 Danio rerio (zebra fish) ENSDARP00000091059 Danio rerio (zebra fish) ENSECAP00000012734 Equus caballus (horse) ENSECAP00000018417 Equus caballus (horse) ENSGALP00000001710 Gallus gallus (chicken) ENSGALP00000037940 Gallus gallus (chicken) ENSP00000309878 Homo sapiens (human) ENSP00000340636 Homo sapiens (human) 91761 Lottia gigantea (owl limpet) ENSMODP00000005261 Monodelphis domestica (gray opossum) ENSMODP00000010602 Monodelphis domestica (gray opossum) ENSMUSP00000081041 Mus musculus (house mouse) ENSMUSP00000112430 Mus musculus (house mouse) XP_001606817.1 Nasonia vitripennis (wasp) LOC_Os07g35680.1 Oryza sativa (asian rice) PHUM002446-PA Pediculus humanus (human body louse) ENSPPYP00000003164 Pongo pygmaeus (orangutan) ENSPPYP00000020767 Pongo pygmaeus (orangutan) ENSPTRP00000005308 Pan troglodytes (chimpanzee) ENSPTRP00000041228 Pan troglodytes (chimpanzee) ENSRNOP00000022253 Rattus norvegicus (norway rat) ENSRNOP00000036885 Rattus norvegicus (norway rat) XP_970831.2 Tribolium castaneum (red flour beetle) ENSTRUP00000008586 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000042243 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000045143 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000005103 Xenopus tropicalis (frog) ENSXETP00000036588 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH12093 ISCW018261 FBgn0242322 FBgn0239235 FBgn0219038 FBgn0213847 FBgn0211061 FBgn0191682 FBgn0186162 FBgn0180310 FBgn0170248 JGI_V11_300042 FBgn0247539 FBgn0080187 FBgn0149627 FBgn0146607 FBgn0010389 FBgn0124813 FBgn0108974 FBgn0107917 FBgn0095265 CPIJ007391 CPIJ018269 BGIBMGA010090 ACYPI002418 GB19884 AGAP003108 AAEL004932 AAEL002172 PB21088 PHUM515380 GLEAN_04713
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	29047 w*; P{hs-λbtl}2 29048 w*; P{hs-λbtl}3 29045 w*; P{UAS-btl.λ}2 29046 w*; P{UAS-btl.λ}1
Harvard	- P{XP}btld11372 - PBac{WH}btlf02864
Kyoto	123127 w1118; P{RS3}btlCB-0322-3
VDRC	v947 w1118; P{GD85}v947 v950 w1118; P{GD85}v950 v27108 w1118 P{GD14439}v27108 v948 w1118; P{GD85}v948/TM3 v27106 w1118; P{GD14439}v27106
	More stocks available...
Genomic Clones ( 2 )
	BACR02M13 BACR35M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 8 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	LD22315
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	47408 82210 107236 121347 EK175144 EK232750 EK241139
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005592 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39564
Antibody Information
	polyclonal (Glazer and Shilo, 1991)
Other Information
Discoverer
	Kennison, 1983.
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: btl dev (Burmester et al., 2000)
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10) Lowered survival and loss of humeral bristles in combination with D3 may indicate allelism with D, but it is difficult to ascertain. (Lindsley and Zimm, 1992)
Other Comments
	btl is required during tracheal branching morphogenesis. A cell at the branch tip requires btl and leads outgrowth. Trailing cells do not require btl. There appears to be competition (involving N-mediated lateral inhibition) between tracheal cells, such that those with the highest btl activity take the lead position at the branch tip and those with less btl activity assume subsidiary positions and form the branch stalk. (Ghabrial and Krasnow, 2006) One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders. (Inlow and Restifo, 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) btl signalling is inhibited by sty. (Reich et al., 1999) btl expression in the developing trachea is regulated by direct interactions between trh/tgo heterodimers and three central midline elements located in the btl minimum enhancer. (Ohshiro and Saigo, 1997) Phylogenetic analysis of the PTK family. (Suga et al., 1997) Tracheal cell migration defects in vvl mutant embryos are rescued by ubiquitous expression of btl. (Anderson et al., 1996) Maintenance of high level btl expression requires wild-type vvl function. Characterisation of btl regulatory sequences identifies seven high affinity and one low affinity vvl recognition elements, implying direct transcriptional regulation of btl expression by vvl. (Anderson et al., 1996) Spatially regulated btl activity guides tracheal cell migration and determines the pattern of secondary and terminal branches by selecting tracheal cell fates. Thus regulation of btl activity is key to each phase of tracheal morphogenesis. (Lee et al., 1996) The btl FGF receptor, required for primary tracheal branching, is also required to activate expression of markers involved in secondary branching. (Samakovlis et al., 1996) bnl appears to function as a ligand for btl. (Sutherland et al., 1996) Mutations of btl interact with Dfd to reduce the viability of the Dfd3/Dfd13 combination. (Harding et al., 1995) btl is a key, direct target of the slbo transcription factor in the regulation of border cell migration. (Murphy et al., 1995) btl is obligatory primarily for the onset of the tracheal migration process and is also required for the formation of tracheoles. (Reichman-Fried and Shilo, 1995) The normal activity of btl in promoting cell migration does not require spatially restricted cues. (Reichman-Fried et al., 1994) Disruption of the trachea, using overlapping deletions that remove btl abolishes the ability of the intersegmental nerve to extend through the lateral part of the embryo. (Giniger et al., 1993) Mutations at btl affect tracheal development, and migration of posterior pair of midline glial cells to posterior commisure. (Klambt et al., 1992) Associated with recessive larval lethality. (Lindsley and Zimm, 1992) The btl gene product participates in receiving spatial clues that guide tracheal cell outgrowth. (Glazer and Shilo, 1991) btl is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. (Kennison and Tamkun, 1988) Isolation: as a dominant suppressor of Pc mutations.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_168577 NM_001014583 RefSeq (Proteins) • NP_729956 NP_001014583 DDBJ / EMBL / GenBank • AAB19904 AAF49759 AAF49759.1 AAX52746 AB002696 AJ002918 AQ026309 AQ034129 BZ665560 CAA05753 CAA40912 CAA51340 CAA52190 G00614 S55971 X57746 X72830 X74031 Entrez Gene - A searchable database of RefSeq genes. • 39564 UniProtKB/Swiss-Prot • Q09147
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like (IPR007110) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, fibroblast growth factor receptor-related (IPR020732) Immunoglobulin-like fold (IPR013783) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64900 DroID - A comprehensive database of gene and protein interactions. • FBgn0005592 DRSC - Results from RNAi screens. • FBgn0005592 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005592 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32134-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005592 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39564 InParanoid A subset of ortholog calls from InParanoid. • AAEL002172-PA Aedes aegypti (mosquito) AGAP003108-PA Anopheles gambiae (mosquito) BGIBMGA010090-PA Bombyx mori (silk worm) ENSBTAP00000009427 Bos taurus (bovine) ENSBTAP00000018708 Bos taurus (bovine) ENSCAFP00000018223 Canis familiaris (dog) ENSCAFP00000024312 Canis familiaris (dog) 300042 Daphnia pulex (daphnia) ENSDARP00000011898 Danio rerio (zebra fish) ENSDARP00000091059 Danio rerio (zebra fish) ENSECAP00000012734 Equus caballus (horse) ENSECAP00000018417 Equus caballus (horse) ENSGALP00000001710 Gallus gallus (chicken) ENSGALP00000037940 Gallus gallus (chicken) ENSP00000309878 Homo sapiens (human) ENSP00000340636 Homo sapiens (human) 91761 Lottia gigantea (owl limpet) ENSMODP00000005261 Monodelphis domestica (gray opossum) ENSMODP00000010602 Monodelphis domestica (gray opossum) ENSMUSP00000081041 Mus musculus (house mouse) ENSMUSP00000112430 Mus musculus (house mouse) XP_001606817.1 Nasonia vitripennis (wasp) LOC_Os07g35680.1 Oryza sativa (asian rice) PHUM002446-PA Pediculus humanus (human body louse) ENSPPYP00000003164 Pongo pygmaeus (orangutan) ENSPPYP00000020767 Pongo pygmaeus (orangutan) ENSPTRP00000005308 Pan troglodytes (chimpanzee) ENSPTRP00000041228 Pan troglodytes (chimpanzee) ENSRNOP00000022253 Rattus norvegicus (norway rat) ENSRNOP00000036885 Rattus norvegicus (norway rat) XP_970831.2 Tribolium castaneum (red flour beetle) ENSTRUP00000008586 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000042243 Takifugu rubripes (pufferfish Takifugu) ENSTRUP00000045143 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000005103 Xenopus tropicalis (frog) ENSXETP00000036588 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/breathls.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39564 modMine - Data generated by the modENCODE project. • FBgn0005592 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • LH12093 ISCW018261 FBgn0242322 FBgn0239235 FBgn0219038 FBgn0213847 FBgn0211061 FBgn0191682 FBgn0186162 FBgn0180310 FBgn0170248 JGI_V11_300042 FBgn0247539 FBgn0080187 FBgn0149627 FBgn0146607 FBgn0010389 FBgn0124813 FBgn0108974 FBgn0107917 FBgn0095265 CPIJ007391 CPIJ018269 BGIBMGA010090 ACYPI002418 GB19884 AGAP003108 AAEL004932 AAEL002172 PB21088 PHUM515380 GLEAN_04713 REDfly - A database of transcriptional regulatory elements. • FBgn0005592
Synonyms & Secondary IDs ( 30 )
Reported As
Symbol Synonym	0844/01 (Deak et al., 1997) btl (Ghabrial and Krasnow, 2006, Myat et al., 2005, Jarvis et al., 2006, Jiang and Crews, 2006, Brodu and Casanova, 2006, Sandmann et al., 2007, Forni et al., 2004, Srahna et al., 2006, Quinones-Coello, 2007, Jones and Metzstein, 2011, Stahl et al., 2007, Yan and Lin, 2008, Petit et al., 2004, Chanut-Delalande et al., 2007, Weaver and Krasnow, 2008, Centanin et al., 2008, Araujo et al., 2007, Chang et al., 2008, Inoue and Hayashi, 2007, Yan and Lin, 2007, Sato et al., 2008, Cabernard and Affolter, 2005, Wolf et al., 2002, Jeon and Zinn, 2009, Zeitlinger et al., 2007, Guha et al., 2009, Hsouna et al., 2007, Wu et al., 2009, Wang et al., 2010, Chanut-Delalande et al., 2010, Baer et al., 2010, Mao and Freeman, 2009, Hsouna et al., 2010, Marco et al., 2009, Chatterjee et al., 2011, Sonnenfeld et al., 2010, Zhan et al., 2010) Btl (Johnson and Perkins, 1996, Wilson et al., 2004, Leatherbarrow and Halfon, 2009) BTL/FGFR2 (Morrison et al., 2000) CG6714 (Morrison et al., 2000, ) CG32134 (Quinones-Coello, 2007, Chang et al., 2008, Keleman et al., 2009.8.5) CT20816 (Hynes and Zhao, 2000) dev (Kankel et al., 2004, Boivin et al., 2003, Yamaguchi et al., 2001, Birchler et al., 2001, Rusch and Kaufman, 2000, Sollars and Ruden, 2000, Staehling-Hampton et al., 1999, Spradling et al., 1999, Vazquez et al., 1999, Maixner et al., 1998, Papoulas et al., 1998, Sollars and Ruden, 1998, Sollars and Ruden, 1997, Carpenter, 1997.1.10, Russell et al., 1996, Sollars and Ruden, 1996, Fauvarque et al., 1995, Harding et al., 1995, Kapoun and Kaufman, 1995, Gindhart and Kaufman, 1995, Kassis, 1994, Kennison, 1993, Kennison and Tamkun, 1988, Vázquez et al., 2008, Petruk et al., 2008) D-FGFR (Matsuda et al., 2003) dFGFR (Matsuda et al., 2006) DFGF-R1 (Shilo, 1993.4.16, Reichman-Fried et al., 1994, Klambt et al., 1992, ) DFR2 (Nagendra et al., 2001, Saigo, 1992.10.28, Emori and Saigo, 1993, Shishido et al., 1993) Dfr-2 (Oates et al., 1998) DmHD-311 (Oates, 1997.11.10, Oates et al., 1998, ) dtk2 (Shishido, 1991.12.2, Shishido et al., 1991) Dtk2   FGFR (Zhu et al., 2003, Dossenbach et al., 2003, Noselli and Perrimon, 2000, Kumar and Moses, 2000, Selleck et al., 2000, Sternberg and Alberola-Ila, 1998, Suga et al., 1997, Kuma et al., 1993, Giniger et al., 1993) Fgf-r (Doctor et al., 1991, ) fgf-r (Glazer and Shilo, 1991) FGFR1 (Mason, 1994, Parakati and Dimario, 2005) HD-311   l(3)00208   Tk2   λtop (Estrada et al., 2006)
Name Synonym	breathless (Klambt et al., 1992, Mortimer and Moberg, 2007, Starz-Gaiano and Montell, 2004, Forni et al., 2004, Okegbe and DiNardo, 2011, Yan and Lin, 2008, Marques, 2005, Weaver and Krasnow, 2008, Centanin et al., 2008, Araujo et al., 2007, Chang et al., 2008, Mortimer and Moberg, 2007, Yan and Lin, 2007, Hurlbut et al., 2009, Wolf et al., 2002, Hsouna et al., 2007, Chung et al., 2009, Baer et al., 2010, Hsouna et al., 2010) Breathless (Kruger, 2006, Cela and Llimargas, 2006, Srahna et al., 2006, Stahl et al., 2007, Weaver and Krasnow, 2008, Hsouna and Hsu, 2008, Wilson et al., 2004, Petit et al., 2004, Voas and Rebay, 2004) devenir   FGF receptor (Selleck et al., 2000, Cinnamon et al., 2007) Fibroblast-growth-factor-receptor   Fibroblast growth factor receptor 1 (Parakati and Dimario, 2005)
Secondary FlyBase IDs
	FBgn0000436 FBgn0000654 FBgn0004412 FBgn0004420 FBgn0004600 FBgn0019834 FBgn0022794 FBgn0052134 FBgn0063611
References ( 311 )
Generate a list of	All references relating to this gene ( 311 )
List References by type	Research paper  ( 165 ) Supplementary material  ( 7 ) Review  ( 63 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 45 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Book  ( 1 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 1 ) Letter  ( 1 ) Automatic genome annotation  ( 1 ) Conference report  ( 3 ) Spoof  ( 1 )
Recent research papers ( 13 )
	Behura et al., 2011, PLoS ONE 6(7): e21504 Comparative Genomic Analysis of Drosophila melanogaster and Vector Mosquito Developmental Genes. [FBrf0214308] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Ghabrial et al., 2011, PLoS Genet. 7(7): e1002087 A systematic screen for tube morphogenesis and branching genes in the Drosophila tracheal system. [FBrf0214368] Jones and Metzstein, 2011, Genetics 189(1): 153--164 A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. [FBrf0215238] Okegbe and DiNardo, 2011, Development 138(7): 1259--1267 The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. [FBrf0213233] Baer et al., 2010, Mech. Dev. 127(1-2): 28--35 The role of apoptosis in shaping the tracheal system in the Drosophila embryo. [FBrf0209865] Chanut-Delalande et al., 2010, PLoS ONE 5(4): e10245 The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development. [FBrf0210685] Dimitriadi et al., 2010, PLoS Genet. 6(10): e1001172 Conserved Genes Act as Modifiers of Invertebrate SMN Loss of Function Defects. [FBrf0212468] Hsouna et al., 2010, Mol. Cell. Biol. 30(15): 3779--3794 Drosophila von hippel-lindau tumor suppressor gene function in epithelial tubule morphogenesis. [FBrf0211250] Pitsouli and Perrimon, 2010, Development 137(21): 3615--3624 Embryonic multipotent progenitors remodel the Drosophila airways during metamorphosis. [FBrf0212055] Sonnenfeld et al., 2010, Dev. Genes Evol. 220(7-8): 207--220 Drosophila Jing is part of the breathless fibroblast growth factor receptor positive feedback loop. [FBrf0214215] Wang et al., 2010, Dev. Cell 18(1): 157--164 Spatial Restriction of FGF Signaling by a Matrix Metalloprotease Controls Branching Morphogenesis. [FBrf0209956] Zhan et al., 2010, PLoS ONE 5(11): e14134 The bHLH Transcription Factor, Hairy, Refines the Terminal Cell Fate in the Drosophila Embryonic Trachea. [FBrf0212509] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...