Posterior sex comb, l(2)49Ea
Gene model reviewed during 5.55
Gene model reviewed during 5.49
Gene model reviewed during 5.56
Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, HDAC1/Rpd3 and Caf1-55. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Psc using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Psc in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
A member of the Su(z)2 complex.
Pc, Scm, Psc, ph-p and ph-d contribute to the PRC1 (Polycomb repressive complex 1). PRC1 directly antagonizes ATP-dependent remodeling of nucleosomal arrays in a purified system and may directly modulate (and be modified by) SWI/SNF (brm/mor) activity.
ph-p, Psc and Pc proteins coimmunoprecipitate from nuclear extracts. Interacting domains are identified and delimited using the two-hybrid system, the interactions are shown to be direct by using an in vitro binding assay.
Psc protein coimmunoprecipitates Pc and ph-d/ph-p indicating they are members of a common multimeric protein complex. These proteins are associated with identical regulatory elements of en and differentially distributed on regulatory sequences of inv.
Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model.
Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.
The mutant phenotypes of Psc, Su(z)2 and Su(z)3, the similarities of the phenotypes and the mutational interactions between them suggest that the products are functionally similar and act at the level of chromatin, possibly as a multimeric complex.
The alleles of Psc define two overlapping phenotypic classes, the 'hopeful' and the 'hapless' alleles.
Members of the Pc group function as potent repressors in mammalian cells.
Molecular analysis revealed similarity to the murine oncogene bmi-1.
Maternal rescue explains the lack of a segmental transformation mutant phenotype in embryos.
Psc and Su(z)2 gene products are nuclear proteins and are associated with more than 80 sites in the salivary gland polytene chromosomes. There is considerable overlap with the sites that are bound by antibodies to z, Pc and the ph-d/ph-p proteins.
The bithorax complex genes are regulated by the Pc group of genes, acting via 'Pc group response elements' (PREs), that can work even when removed from the normal the bithorax complex context. The Pc group products apparently provide stable memory or imprinting of boundaries which are specified by gap and pair-rule regulators.
A member of the Polycomb group of genes. May be considered a negative regulator of the BXC or the ANTC.
The mutant is homo- and hemizygous lethal, the embryos showing partial transformation of head and thorax into abdomen and of abdominal segments 1-7 into more posterior ones. Psc1/Psc1 embryos that are also homozygous for Asx1, Pcl1, or Scm1 show stronger posteriorly-directed transformations; Psc1/+ males may have sex combs on second and third legs. Viability reduced in transheterozygotes in some Psc1/Su(z)2 combinations, lethal in others.
Embryos mutant for two or more Pc-group genes (Pc, Scm, Pcl, Psc, Asx, E(Pc), E(z), ph-d, pho and esc) show strong ectopic en expression, but only weak derepression occurs if embryo is mutant at only one of the Pc group genes.
Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Scm, Pcl, Sce, Asx, Psc, pho and Antp) cause abnormal segmental development due to the ectopic expression of abd-A and Abd-B.
The Pc group genes are negative regulators of homeotic genes and have pleiotropic effects on development.
Identification: Isolated from a genomic library using a mouse bmi-1 cDNA as a probe.
Involved in the suppression of the z1 eye colour and associated with homeotic transformations.