General Information
Symbol
Dmel\Psc
Species
D. melanogaster
Name
Posterior sex combs
Annotation Symbol
CG3886
Feature Type
FlyBase ID
FBgn0005624
Gene Model Status
Stock Availability
Gene Snapshot
Posterior sex combs was originally identified as a member of the Polycomb group of genes that regulate gene expression through epigenetic marks. [Date last reviewed: 2016-06-23]
Also Known As
l(2)49Ea
Genomic Location
Cytogenetic map
Sequence location
2R:12,965,997..12,980,994 [-]
Recombination map
2-67
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
RING FINGER DOMAIN PROTEINS -
The RING (Really Interesting New Gene) finger domain co-ordinates two Zn2+ ions via conserved Cys and His residues. Most proteins which contain a RING finger are assumed to be ubiquitin (E3) ligases. The RING finger binds ubiquitin-conjugating enzymes (E2) and promotes direct transfer of ubiquitin to the target protein. (Adapted from FBrf0215242 and PMID:19489725).
dRING-ASSOCIATED FACTORS -
The Drosophila Polycomb group complex dRING-associated factors (dRAF) catalyzes histone H2A K119 ubiquitination and H3K36me2 removal. Therefore, dRAF removes an active mark from histone H3 and adds a repressive one to H2A. (Adapted from FBrf0215737).
POLYCOMB REPRESSIVE COMPLEX 1 (CORE SUBUNITS) -
The Polycomb repressive complex 1 (PRC1) is a Polycomb group complex. It binds to histone H3K27me3 (histone H3 K27 methylation is catalyzed by PRC2) and monoubiquitinates H2A on K119. This leads to chromatin compaction, RNA polymerase II stalling and gene silencing. (Adapted from FBrf0179742 and FBrf0228921).
UniProt Contributed Function Data
Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Needed to maintain expression patterns of the homeotic selector genes of the Antennapedia (Antp-C) and Bithorax (BX-C) complexes, and hence for the maintenance of segmental determination.
(UniProt, P35820)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
Psc: Posterior sex combs
Psc+ is another gene that may be considered a negative regulator of the BXC or the ANTC. The mutant is homo- and hemizygous lethal, the embryos showing partial transformation of head and thorax into abdomen and of abdominal segments 1-7 into more posterior ones. Psc/Psc embryos that are also homozygous for Asx, Pcl, or Scm show stronger posteriorly-directed transformations; the triple mutant Psc Asx Pcl has a tandem array of posterior abdominal segments including four abdominal denticle bands in the head region (Jurgens, 1985). Psc/+ males may have sex combs on second and third legs. The gene suppresses z1 eye color, which becomes orange-maroon; it is lethal with Su(z)21 and Su(z)25 and semiviable with Su(z)24 (Wu et al., 1989). Psc and Su(z)2 are both members of the Su(z)2 complex.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Psc or the JBrowse view of Dmel\Psc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.55
Gene model reviewed during 5.49
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0087798
6007
1601
FBtr0345196
5671
1601
FBtr0345375
6332
1601
Additional Transcript Data and Comments
Reported size (kB)
6.0 (longest cDNA)
6.6 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0086911
169.8
1601
10.41
FBpp0311395
169.8
1601
10.41
FBpp0311526
169.8
1601
10.41
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1601 aa isoforms: Psc-PA, Psc-PB, Psc-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
(UniProt, P35820)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Psc using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
inferred from sequence model
Biological Process (8 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from direct assay
inferred from direct assay
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000850589
(assigned by GO_Central )
traceable author statement
Expression Data
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain

Comment: reference states 24 hr APF

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Psc in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 45 )
For All Classical and Insertion Alleles Show
 
Allele of Psc
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
      Other relevant insertions
      miscellaneous insertions
      Transgenic Constructs ( 12 )
      Deletions and Duplications ( 41 )
      Disrupted in
      Summary of Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      Other Phenotypes
      Allele
      Phenotype manifest in
      Allele
      abdomen & macrochaeta
      costal vein & macrochaeta
      dorsal double row & macrochaeta
      dorsal triple row & macrochaeta
      head & macrochaeta
      leg & macrochaeta
      mesothoracic leg & sex comb tooth | ectopic
      metathoracic leg & sex comb tooth | ectopic
      scutellum & macrochaeta
      scutum & macrochaeta
      ventral double row & macrochaeta
      ventral triple row & macrochaeta
      Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (9)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      7 of 15
      Yes
      Yes
      6 of 15
      No
      Yes
      5 of 15
      No
      Yes
      3 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      No
      1 of 15
      No
      Yes
      1 of 15
      No
      Yes
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (8)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      8 of 15
      Yes
      Yes
       
      5 of 15
      No
      Yes
      3 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      No
      1 of 15
      No
      Yes
      1 of 15
      No
      Yes
      Rattus norvegicus (Norway rat) (9)
      6 of 13
      Yes
      Yes
      6 of 13
      Yes
      Yes
      3 of 13
      No
      No
      2 of 13
      No
      No
      2 of 13
      No
      Yes
      2 of 13
      No
      No
      1 of 13
      No
      Yes
      1 of 13
      No
      No
      1 of 13
      No
      No
      Xenopus tropicalis (Western clawed frog) (5)
      6 of 12
      Yes
      Yes
      3 of 12
      No
      No
      1 of 12
      No
      Yes
      1 of 12
      No
      No
      1 of 12
      No
      Yes
      Danio rerio (Zebrafish) (8)
      8 of 15
      Yes
      Yes
      8 of 15
      Yes
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      No
      1 of 15
      No
      Yes
      1 of 15
      No
      No
      1 of 15
      No
      Yes
      Caenorhabditis elegans (Nematode, roundworm) (2)
      3 of 15
      Yes
      No
      1 of 15
      No
      No
      Arabidopsis thaliana (thale-cress) (5)
      1 of 9
      Yes
      No
      1 of 9
      Yes
      Yes
      1 of 9
      Yes
      No
      1 of 9
      Yes
      No
      1 of 9
      Yes
      Yes
      Saccharomyces cerevisiae (Brewer's yeast) (2)
      1 of 15
      Yes
      Yes
      1 of 15
      Yes
      Yes
      Schizosaccharomyces pombe (Fission yeast) (1)
      1 of 12
      Yes
      Yes
      Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091904S4 )
      Organism
      Common Name
      Gene
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila melanogaster
      fruit fly
      Drosophila suzukii
      Spotted wing Drosophila
      Drosophila simulans
      Drosophila sechellia
      Drosophila erecta
      Drosophila yakuba
      Drosophila ananassae
      Drosophila pseudoobscura pseudoobscura
      Drosophila persimilis
      Drosophila willistoni
      Drosophila virilis
      Drosophila mojavensis
      Drosophila grimshawi
      Drosophila grimshawi
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502M4 )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Musca domestica
      House fly
      Glossina morsitans
      Tsetse fly
      Lucilia cuprina
      Australian sheep blowfly
      Mayetiola destructor
      Hessian fly
      Aedes aegypti
      Yellow fever mosquito
      Anopheles darlingi
      American malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06BU )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Bombyx mori
      Silkmoth
      Danaus plexippus
      Monarch butterfly
      Heliconius melpomene
      Postman butterfly
      Apis florea
      Little honeybee
      Apis florea
      Little honeybee
      Apis mellifera
      Western honey bee
      Apis mellifera
      Western honey bee
      Bombus impatiens
      Common eastern bumble bee
      Bombus impatiens
      Common eastern bumble bee
      Bombus impatiens
      Common eastern bumble bee
      Bombus terrestris
      Buff-tailed bumblebee
      Bombus terrestris
      Buff-tailed bumblebee
      Linepithema humile
      Argentine ant
      Linepithema humile
      Argentine ant
      Megachile rotundata
      Alfalfa leafcutting bee
      Megachile rotundata
      Alfalfa leafcutting bee
      Nasonia vitripennis
      Parasitic wasp
      Nasonia vitripennis
      Parasitic wasp
      Dendroctonus ponderosae
      Mountain pine beetle
      Dendroctonus ponderosae
      Mountain pine beetle
      Tribolium castaneum
      Red flour beetle
      Tribolium castaneum
      Red flour beetle
      Tribolium castaneum
      Red flour beetle
      Pediculus humanus
      Human body louse
      Pediculus humanus
      Human body louse
      Pediculus humanus
      Human body louse
      Rhodnius prolixus
      Kissing bug
      Rhodnius prolixus
      Kissing bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Acyrthosiphon pisum
      Pea aphid
      Acyrthosiphon pisum
      Pea aphid
      Acyrthosiphon pisum
      Pea aphid
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Zootermopsis nevadensis
      Nevada dampwood termite
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X067F )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strigamia maritima
      European centipede
      Strigamia maritima
      European centipede
      Ixodes scapularis
      Black-legged tick
      Ixodes scapularis
      Black-legged tick
      Stegodyphus mimosarum
      African social velvet spider
      Stegodyphus mimosarum
      African social velvet spider
      Tetranychus urticae
      Two-spotted spider mite
      Tetranychus urticae
      Two-spotted spider mite
      Daphnia pulex
      Water flea
      Daphnia pulex
      Water flea
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09IB )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Ciona intestinalis
      Vase tunicate
      Ciona intestinalis
      Vase tunicate
      Gallus gallus
      Domestic chicken
      Gallus gallus
      Domestic chicken
      Human Disease Model Data
      FlyBase Human Disease Model Reports
      Alleles Reported to Model Human Disease (Disease Ontology)
      Download
      Models ( 0 )
      Allele
      Disease
      Evidence
      References
      Interactions ( 1 )
      Allele
      Disease
      Interaction
      References
      Comments ( 0 )
       
      Human Orthologs (via DIOPT v7.1)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser

      Please look at the Interaction Group reports for full details of the physical interactions
      protein-protein
      Interacting group
      Assay
      References
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Component of PRC1 complex, which contains many PcG proteins like Pc, ph, Scm, Psc, Sce and also chromatin-remodeling proteins such as histone deacetylases. This complex is distinct from the Esc/E(z) complex, at least composed of esc, E(z), Su(z)12, Rpd3 and Caf1. The 2 complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
      (UniProt, P35820 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      Pathways
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map
      2-67
      Cytogenetic map
      Sequence location
      2R:12,965,997..12,980,994 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      49E6-49E6
      Limits computationally determined from genome sequence between P{PZ}l(2)0142401424 and P{lacW}Psck07834&P{lacW}Su(z)2k06344
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      49E6-49E7
      (determined by in situ hybridisation)
      49E-49E
      (determined by in situ hybridisation)
      Experimentally Determined Recombination Data
      Left of (cM)
      Right of (cM)
      Notes
      Mapping based on 234 recombinants of Psc1. Homeotic and eye color effects cosegregate among 110 recombinants in the Bl-L interval.
      Stocks and Reagents
      Stocks (26)
      Genomic Clones (23)
      cDNA Clones (18)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of
        Additional comments
        A member of the Su(z)2 complex.
        Other Comments
        Psc on its own is able to inhibit chromatin remodelling in vitro.
        Pc, Scm, Psc, ph-p and ph-d contribute to the PRC1 (Polycomb repressive complex 1). PRC1 directly antagonizes ATP-dependent remodeling of nucleosomal arrays in a purified system and may directly modulate (and be modified by) SWI/SNF (brm/mor) activity.
        ph-p, Psc and Pc proteins coimmunoprecipitate from nuclear extracts. Interacting domains are identified and delimited using the two-hybrid system, the interactions are shown to be direct by using an in vitro binding assay.
        Psc protein coimmunoprecipitates Pc and ph-d/ph-p indicating they are members of a common multimeric protein complex. These proteins are associated with identical regulatory elements of en and differentially distributed on regulatory sequences of inv.
        Asx, Pc, Pcl, Psc, Scm and Sce have similar functions in some imaginal tissues.
        Most duplications of Pc-group genes neither exhibit anterior transformations nor suppress the extra sex comb phenotype of Pc-group mutations, suggesting that not all Pc-group genes behave as predicted by the mass action model.
        Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes.
        Mosaic and expression pattern analysis reveals that the Pc-group genes do not act only in a common complex or pathway: they must have some independent functions.
        The mutant phenotypes of Psc, Su(z)2 and Su(z)3, the similarities of the phenotypes and the mutational interactions between them suggest that the products are functionally similar and act at the level of chromatin, possibly as a multimeric complex.
        The alleles of Psc define two overlapping phenotypic classes, the 'hopeful' and the 'hapless' alleles.
        The distinction between 'hopeful' and 'hapless' alleles and intragenic complementation seen among some Psc alleles are consistent with a multidomain structure for the Psc product.
        Members of the Pc group function as potent repressors in mammalian cells.
        Psc is one of several Pc-G genes required for the repression of gap genes by maternally supplied hb product.
        Psc is not essential for normal bristle differentiation.
        Mutations in Psc generate malformations of the longitudinal tracts.
        Psc binds polytene chromosomes at 45 locations where other Pc-group proteins, encoded by the Pc and ph-d/ph-p genes, are present.
        Molecular analysis revealed similarity to the murine oncogene bmi-1.
        Maternal rescue explains the lack of a segmental transformation mutant phenotype in embryos.
        Psc and Su(z)2 gene products are nuclear proteins and are associated with more than 80 sites in the salivary gland polytene chromosomes. There is considerable overlap with the sites that are bound by antibodies to z, Pc and the ph-d/ph-p proteins.
        The association of the Psc and Su(z)2 proteins with the chromosomes is dependent on the presence of active E(z) protein.
        The bithorax complex genes are regulated by the Pc group of genes, acting via 'Pc group response elements' (PREs), that can work even when removed from the normal the bithorax complex context. The Pc group products apparently provide stable memory or imprinting of boundaries which are specified by gap and pair-rule regulators.
        A member of the Polycomb group of genes. May be considered a negative regulator of the BXC or the ANTC.
        The mutant is homo- and hemizygous lethal, the embryos showing partial transformation of head and thorax into abdomen and of abdominal segments 1-7 into more posterior ones. Psc1/Psc1 embryos that are also homozygous for Asx1, Pcl1, or Scm1 show stronger posteriorly-directed transformations; Psc1/+ males may have sex combs on second and third legs. Viability reduced in transheterozygotes in some Psc1/Su(z)2 combinations, lethal in others.
        Embryos mutant for two or more Pc-group genes (Pc, Scm, Pcl, Psc, Asx, E(Pc), E(z), ph-d, pho and esc) show strong ectopic en expression, but only weak derepression occurs if embryo is mutant at only one of the Pc group genes.
        Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Mutations of genes in the polycomb group (esc, E(z), Pc, ph-p, ph-d, Scm, Pcl, Sce, Asx, Psc, pho and Antp) cause abnormal segmental development due to the ectopic expression of abd-A and Abd-B.
        Aberrant Psc gene expression results in abnormal bristle development.
        The Pc group genes are negative regulators of homeotic genes and have pleiotropic effects on development.
        Identification: Isolated from a genomic library using a mouse bmi-1 cDNA as a probe.
        Involved in the suppression of the z1 eye colour and associated with homeotic transformations.
        Dominantly suppresses the yellow eye colour of z1 flies.
        The triple mutant Psc1 Asx1 Pcl1 has a tandem array of posterior abdominal segments including four abdominal denticle bands in the head region.
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 74 )
        Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Linkouts
        ApoDroso - Functional genomic database for photoreceptor development, survival and function
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        Flygut - An atlas of the Drosophila adult midgut
        FlyMine - An integrated database for Drosophila genomics
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Synonyms and Secondary IDs (19)
        Reported As
        Symbol Synonym
        D-Bmi
        Psc
        (Levis, 2018.8.30, Ma et al., 2018, Nishioka et al., 2018, Rennie et al., 2018, Sadasivam and Huang, 2018, Erceg et al., 2017, Huang et al., 2017, Kang et al., 2017, Maini et al., 2017, Monribot-Villanueva et al., 2017, Schwartz and Cavalli, 2017, Transgenic RNAi Project members, 2017-, Bielmeier et al., 2016, Du et al., 2016, Frey et al., 2016, Kahn et al., 2016, Morimoto et al., 2016, Peng et al., 2016, Piunti and Shilatifard, 2016, Shih et al., 2016, Bivik et al., 2015, Dequéant et al., 2015, Dietz et al., 2015, Finley et al., 2015, Ghasemi et al., 2015, Kang et al., 2015, Schertel et al., 2015, Ashwal-Fluss et al., 2014, Comoglio and Paro, 2014, Gambetta and Müller, 2014, Herz et al., 2014, McElroy et al., 2014, Aloia et al., 2013, Bengani et al., 2013, Collins and Moon, 2013, Debruhl et al., 2013, Di Croce and Helin, 2013, Lim et al., 2013, Sen et al., 2013, Vasanthi et al., 2013, Beh et al., 2012, Feller et al., 2012, Follmer et al., 2012, Gutiérrez et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ji et al., 2012, McEachern, 2012, Morillo Prado et al., 2012, Park et al., 2012, Sakoparnig et al., 2012, Stern et al., 2012, Di Stefano et al., 2011, Du et al., 2011, Enderle et al., 2011, Grau et al., 2011, Klusza and Deng, 2011, Singer and Gall, 2011, Strübbe et al., 2011, Bell et al., 2010, Brown and Kassis, 2010, Gandille et al., 2010, Gan et al., 2010, Grau et al., 2010, Li et al., 2010, Schwartz et al., 2010, Classen et al., 2009, Emmons et al., 2009, Fang et al., 2009, Khan et al., 2009, Sing et al., 2009, Southall and Brand, 2009, Berger et al., 2008, Diop et al., 2008, Doheny et al., 2008, Kim et al., 2008, Matyunina et al., 2008, Oktaba et al., 2008, Zhang et al., 2008, Bai et al., 2007, Beisel et al., 2007, Bello et al., 2007, Buszczak et al., 2007, de Ayala Alonso et al., 2007, Goodliffe et al., 2007, Mishra et al., 2007, Schuettengruber et al., 2007, Secombe et al., 2007, Holmes et al., 2006, Kavi et al., 2006, Muller and Kassis, 2006, Papp and Muller, 2006, Qi et al., 2006, Schwartz et al., 2006, Brown et al., 2005, King et al., 2005, Ali and Bender, 2004, Breiling et al., 2004, Wang and Brock, 2003, Balasov, 2002, Huang et al., 2002, King et al., 2002, Fitzgerald and Bender, 2001, Hirose et al., 2001)
        Su(z)2-C
        l(2)vr14
        Secondary FlyBase IDs
        • FBgn0002071
        • FBgn0003153
        • FBgn0003644
        Datasets (2)
        Study focus (2)
        Experimental Role
        Project
        Project Type
        Title
        • bait_protein
        Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.
        • bait_protein
        Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.
        References (388)