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Gene Dmel\lola

General Information
Symbol	Dmel\lola	Species	D. melanogaster
Name	longitudinals lacking	Annotation symbol	CG12052
Feature type	protein_coding_gene	FlyBase ID	FBgn0005630
Gene Model Status	Current	Stock availability	70 publicly available
Also Known As	CG18378, eyeful, CG18381, BTB-IV
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	47A11-47A13	Sequence location	2R:6,369,712..6,430,794 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene longitudinals lacking is referred to in FlyBase by the symbol Dmel\lola (CG12052, FBgn0005630). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 14 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; locomotion; multi-organism process; sensory organ development; organ morphogenesis; immune response; behavior; neuromuscular process; behavioral interaction between organisms; cell projection organization; biological regulation; cellular process involved in reproduction. 181 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; abdominal lateral monoscolopidial chordotonal organ lch1; embryonic/larval neuron; hypodermal muscle of larval abdomen; abdominal lateral pentascolopidial chordotonal organ lch5; adult segment; multi-cell-component structure; larval abdominal segment; eo support cell; presumptive embryonic/larval nervous system. It has 26 annotated transcripts and 26 annotated polypeptides. Protein features are: BTB/POZ; BTB/POZ fold; BTB/POZ-like; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Gene sequence location is 2R:6369712..6430794.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	References Vallejo et al., 2011, EMBO J. 30(4): 756--769 Cunha et al., 2010, PLoS Genet. 6: e1001014 Sequence features HFA06740 BKN30256 HFA05222 HFA07647 HFA06739 HFA05221 HFA05223 HFA05224 HFA05220 HFA06742 HFA07646 HFA06741 HFA06738
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 47A11-47A13   Limits computationally determined from genome sequence between P{lacW}Hr46k10308 and P{PZ}lola00349&P{EP}lolaEP952
Experimentally Determined Cytological Location
Cytogenetic map Notes References 47A13-47A13   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000) 47A-47A     (Laski, 1994.9.5) 47A11-47A12   (determined by in situ hybridisation)   (Spradling et al., 1999) 47A13-47A16   (determined by in situ hybridisation)   (Berg, 1996.2.28) 47A9-47A14   (determined by in situ hybridisation)   (Giniger et al., 1994) 47A11-47A12     (BDGP Project Members, 1994-1999) 47A11-47A14   (determined by in situ hybridisation)   (Seeger et al., 1993)
Experimentally Determined Recombination Data
Location	2- (Laski, 1994.9.5)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lola for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lola-RA FBtr0089344  NM_170623   2948   706 lola-RB FBtr0089343  NM_170619   2977   787 lola-RC FBtr0089345  NM_170618   3132   787 lola-RD FBtr0089349  NM_170620   3469   748 lola-RE FBtr0089342  NM_170621   3420   748 lola-RF FBtr0089348  NM_170622   2673   565 lola-RG FBtr0089347  NM_080027   3963   891 lola-RH FBtr0089346  NM_170617   2155   518 lola-RI FBtr0089350  NM_176133   4285   970 lola-RJ FBtr0089360  NM_176130   3712   757 lola-RK FBtr0089353  NM_176136   2101   546 lola-RL FBtr0089352  NM_176138   2869   608 lola-RM FBtr0089362  NM_176140   2102   465 lola-RN FBtr0089354  NM_176128   3309   878 lola-RO FBtr0089361  NM_176129   3243   668 lola-RP FBtr0089355  NM_176131   3884   963 lola-RQ FBtr0089356  NM_176139   2373   603 lola-RR FBtr0089357  NM_176132   4013   891 lola-RS FBtr0089358  NM_176137   2918   720 lola-RT FBtr0089359  NM_176134   2291   575 lola-RU FBtr0089351  NM_176135   2242   575 lola-RV FBtr0089363  NM_206085   2484   549 lola-RW FBtr0089364  NM_206084   3455   771 lola-RX FBtr0089365  NM_206083   2947   602 lola-RY FBtr0089366  NM_206082   2406   577 lola-RZ FBtr0100286  NM_001032229   2753   665
Additional Transcript Data & Comments
Reported size (kB)	4.9, 4.7, 3.8 (northern blot) (Giniger et al., 1994) 3.9 (northern blot) (Zhang et al., 2003)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lola-PA   FBpp0088378   75.8   706   5.15     NP_724953   AAF58775 lola-PB   FBpp0088377   82.2   787   6.14     NP_724949   AAF58776 lola-PC   FBpp0088379   82.2   787   6.14     NP_724946   AAF58773 lola-PD   FBpp0088383   79.4   748   5.48     NP_724950   AAM68765 lola-PE   FBpp0088376   79.4   748   5.48     NP_724951   AAM68766 lola-PF   FBpp0088382   60.7   565   6.09     NP_724952   AAM68767 lola-PG   FBpp0088381   96.3   891   6.43     NP_524766   AAF58782 lola-PH   FBpp0088380   55.4   518   4.97     NP_724945   AAF58777 lola-PI   FBpp0088384   105.8   970   6.11     NP_788313   AAO41426 lola-PJ   FBpp0088394   78.7   757   6.63     NP_788310   AAF58779 lola-PK   FBpp0088387   58.9   546   6.27     NP_788316   AAM68764 lola-PL   FBpp0088386   65.4   608   6.61     NP_788318   AAO41430 lola-PM   FBpp0088396   49.3   465   4.80     NP_788320   AAO41431 lola-PN   FBpp0088388   96.2   878   5.78     NP_788308   AAF58781 lola-PO   FBpp0088395   71.8   668   4.64     NP_788309   AAO41424 lola-PP   FBpp0088389   102.7   963   5.14     NP_788311   AAF58778 lola-PQ   FBpp0088390   64.7   603   8.12     NP_788319   AAM68768 lola-PR   FBpp0088391   96.3   891   6.43     NP_788312   AAO41425 lola-PS   FBpp0088392   77.0   720   6.73     NP_788317   AAO41429 lola-PT   FBpp0088393   61.9   575   6.21     NP_788314   AAO41427 lola-PU   FBpp0088385   61.9   575   6.21     NP_788315   AAO41428 lola-PV   FBpp0088949   59.3   549   5.20     NP_995807   AAS64877 lola-PW   FBpp0088950   83.5   771   5.66     NP_995806   AAS64876 lola-PX   FBpp0088951   64.4   602   5.84     NP_995805   AAS64874 lola-PY   FBpp0088948   62.7   577   5.19     NP_995804   AAS64875 lola-PZ   FBpp0099680   70.9   665   6.60     NP_001027400   AAZ52818
Additional Polypeptide Data & Comments
Reported size (kDa)	894, 467 (aa); 97, 50 (kD predicted) (Giniger et al., 1994) 748 (aa); 105 (kD) (Zhang et al., 2003)
Comments	Although the calculated mass of the zf5 lola isoform is79.4 kD, it migrates at 105 kD perhaps because of its low pI. (Zhang et al., 2003)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201835   AA201917   AA202291   AA202463   AA202496   AA202650   AA202808   AA203096   AA246207   AA246496   AA246541   AA264136   AA264602   AA264702   AA390332   AA390656   AA390681   AA390737   AA391102   AA391670   AA391891   AA392150   AA392659   AA392689   AA438280   AA438349   AA438382   AA438406   AA438870   AA438879   AA438894   AA439006   AA439244   AA439452   AA439458   AA439551   AA439615   AA439854   AA440057   AA440428   AA440604   AA440756   AA441086   AA441592   AA441616   AA536406   AA536507   AA536597   AA538609   AA538984   AA539500   AA539948   AA540007   AA540040   AA540116   AA540296   AA540469   AA540786   AA541121   AA567535   AA568055   AA694839   AA696650   AA697178   AA697825   AA735193   AA816811   AA820404   AA820773   AA820982   AA949220   AA949911   AA950025   AA951004   AA951529   AA951878   AA951904   AA951985   AA978637   AA979022   AA979178   AA979185   AA979401   AA979447   AA979598   AA990725   AA990805   AE013599 AAF58773   AE013599 AAF58775   AE013599 AAF58776   AE013599 AAF58777   AE013599 AAF58778   AE013599 AAF58779   AE013599 AAF58781   AE013599 AAF58782   AE013599 AAM68764   AE013599 AAM68765   AE013599 AAM68766   AE013599 AAM68767   AE013599 AAM68768   AE013599 AAO41424   AE013599 AAO41425   AE013599 AAO41426   AE013599 AAO41427   AE013599 AAO41428   AE013599 AAO41429   AE013599 AAO41430   AE013599 AAO41431   AE013599 AAS64874   AE013599 AAS64875   AE013599 AAS64876   AE013599 AAS64877   AE013599 AAZ52818   AB107272   AB107273   AB107274   AB107275   AB107276   AB107277   AB107278   AB107279   AB107280   AB107281   AB107282   AB107283   AB107284   AB107285   AB107286   AB107287   AB107288   AB107289   AB107290   AB107291   AB107292   AB107293   AB107294   AB107295   AB107296   AB107297   AB107298   AB107299   AB107300   AB107301   AB107302   AB107303   AB107304   AB107305   AB107306   AB107307   AB107308 BAC67613   AB107309 BAC67614   AB107310 BAC67615   AB107311 BAC67616   AB107312 BAC67617   AB107313 BAC67618   AB107314 BAC67619   AB107315 BAC67620   AB107316 BAC67621   AB107317 BAC67622   AB107318 BAC67623   AB107319 BAC67624   AB107320 BAC67625   AB107321 BAC67626   AB107322 BAC67627   AB107323 BAC67628   AB107324 BAC67629   AB107325 BAC67630   AB107326 BAC67631   AB107327 BAC67632   AB107328 BAC67633   AB107329 BAC67634   AB107330 BAC67635   AB107331 BAC67636   AB107332 BAC67637   AB107333 BAC67638   AB107334 BAC67639   AB107335 BAC67640   AB107336 BAC67641   AB107337 BAC67642   AB107338 BAC67643   AB107339 BAC67644   AB107340 BAC67645   AB107341 BAC67646   AB107342 BAC67647   AB107343 BAC67648   AB107344 BAC67649   AB107345 BAC67650   AB107346 BAC67651   AB107347 BAC67652   AB107348 BAC67653   AB107349 BAC67654   AB107350 BAC67655   AB107351 BAC67656   AI109185   AI297320   AI297579   AI405884   AI456193   AI511761   AI513411   AI513656   AI515835   AI516769   AI519305   AI519443   AI520425   AI534081   AI541938   AI546340   AI944838   AQ024998   AQ025981   AQ026006   AQ072907   AQ072929   AQ073258   AQ073490   AQ073534   AQ073552   AQ073670   AQ073738   AQ073746   AQ073747   AQ254790   AQ254857   AW940296   AW941966   AW942043   AW942437   AW942791   AY058586 AAL13815   AY060256 AAL25295   AY060963 AAL28511   AY102680 AAM27509   AY231933   BE975159   BF493889   BF496727   BF499166   BG633546   BG636677   BG638710   BI162071   BI162072   BI162434   BI162919   BI163839   BI163972   BI164015   BI164254   BI164308   BI164821   BI164949   BI165682   BI165909   BI166220   BI166485   BI167319   BI167408   BI167538   BI167944   BI168214   BI168735   BI168879   BI169309   BI169829   BI170030   BI170070   BI170351   BI170460   BI170616   BI171200   BI171439   BI171548   BI171564   BI171660   BI172015   BI172223   BI172244   BI173374   BI173433   BI173435   BI173607   BI173679   BI173701   BI173787   BI173947   BI212261   BI212475   BI212987   BI213031   BI213349   BI213421   BI213425   BI214131   BI214583   BI214620   BI214678   BI214756   BI215137   BI215292   BI215330   BI215347   BI215397   BI215484   BI215544   BI215685   BI215988   BI216103   BI216125   BI216637   BI228184   BI228362   BI228448   BI228567   BI228695   BI228714   BI229365   BI229416   BI229486   BI229871   BI230272   BI230555   BI230853   BI231174   BI231431   BI231774   BI232042   BI232158   BI232625   BI233050   BI234044   BI234352   BI234574   BI235020   BI235048   BI235082   BI235457   BI235523   BI236557   BI237468   BI237600   BI237648   BI237889   BI238447   BI238556   BI239003   BI239125   BI239131   BI239147   BI239154   BI239244   BI239645   BI239812   BI239893   BI240313   BI240551   BI240867   BI240902   BI241285   BI241814   BI242231   BI242574   BI242615   BI242845   BI243033   BI354668   BI356073   BI356179   BI356611   BI356750   BI356949   BI357219   BI357891   BI357896   BI358066   BI358137   BI358180   BI358501   BI361286   BI361317   BI362268   BI362924   BI362940   BI363132   BI363147   BI363149   BI363287   BI363627   BI364083   BI364442   BI365205   BI365241   BI365700   BI366870   BI367020   BI367116   BI367190   BI367418   BI368285   BI371976   BI371994   BI372030   BI372073   BI372075   BI372076   BI372091   BI372171   BI373108   BI373173   BI373448   BI373776   BI373875   BI373965   BI374419   BI374568   BI375648   BI375910   BI376098   BI376164   BI482190   BI482363   BI482628   BI483098   BI483596   BI484396   BI484567   BI485165   BI485915   BI486122   BI486514   BI487168   BI571720   BI575014   BI575699   BI577658   BI578834   BI580290   BI580400   BI583139   BI583511   BI583801   BI589862   BI590568   BI591316   BI605764   BI606204   BI606420   BI612535   BI617108   BI621612   BI628657   BI629648   BI637273   BI639435   BI640963   BP540518   BP540519   BP541007   BP541008   BP544189   BP544190   BP547054   BP547186   BP549095   BP549096   BP549157   BP549158   BP554857   BP554858   BP555135   BP555136   BP555361   BP555362   BP556309   BP556310   BP557411   BP557412   BP558170   BP558171   BP558681   BP558682   BP559564   BP559565   BQ103000   BT001807 AAN71562   BT004909 AAO49162   BT029109   BT120030   BT126102   BX023252   CA804611   CK660717   CL610266   CO153238   CO154819   CO155577   CO157025   CO176973   CO178215   CO187248   CO189089   CO189101   CO190501   CO196289   CO262184   CO262484   CO263515   CO264051   CO264120   CO264715   CO264717   CO264776   CO265029   CO265083   CO266929   CO267063   CO267153   CO267287   CO267544   CO267592   CO268103   CO270895   CO271199   CO271323   CO271534   CO271929   CO274779   CO277494   CO278497   CO279027   CO279735   CO281290   CO281294   CO281931   CO281982   CO282255   CO282812   CO282897   CO282919   CO283443   CO283581   CO283739   CO283901   CO284489   CO284742   CO285029   CO285208   CO285254   CO285599   CO285609   CO285969   CO286104   CO286106   CO286233   CO286761   CO286842   CO287179   CO288558   CO289107   CO289128   CO289551   CO289683   CO290743   CO291055   CO292909   CO293720   CO294625   CO296948   CO296977   CO297378   CO298013   CO298472   CO298793   CO299418   CO299785   CO300004   CO300553   CO301098   CO302289   CO303157   CO303237   CO303642   CO305143   CO305153   CO305827   CO306129   CO306141   CO306267   CO306270   CO306428   CO307122   CO307452   CO308638   CO308758   CO308983   CO310340   CO310699   CO311242   CO311509   CO312043   CO312113   CO312798   CO312906   CO313052   CO313503   CO313847   CO314036   CO314053   CO314127   CO314315   CO314840   CO314898   CO315038   CO316391   CO316715   CO317276   CO317647   CO318109   CO318835   CO321150   CO321469   CO321912   CO322687   CO322695   CO323481   CO324082   CO324518   CO325267   CO326022   CO326034   CO326966   CO327059   CO327306   CO327738   CO328956   CO328961   CO329180   CO329513   CO330092   CO330138   CO330181   CO330370   CO331910   CO332031   CO332349   CO332785   CO332981   CO333011   CO333236   CO333274   CO333376   CO333475   CO333498   CO333983   CO334069   CO335825   CO337978   CO338760   CO339105   CO340245   CO340378   CO340828   CO342341   CZ467549   CZ467550   CZ471740   CZ472208   CZ472414   CZ472415   CZ472946   CZ473569   CZ473570   CZ473780   CZ473811   CZ475133   CZ475134   CZ475251   CZ476737   CZ477080   CZ478037   CZ481737   CZ486504   CZ486505   CZ487327   CZ488075   CZ488076   DN154129   DN154408   EC053266   EC057737   EC057897   EC058084   EC060143   EC060811   EC060872   EC060975   EC061276   EC061577   EC061973   EC062180   EC063806   EC063831   EC064861   EC064902   EC064975   EC065632   EC065838   EC066480   EC067420   EC067448   EC067933   EC068493   EC069376   EC069595   EC069638   EC069982   EC070405   EC070503   EC070837   EC071504   EC071774   EC071929   EC072342   EC072573   EC072650   EC072923   EC073159   EC073275   EC073282   EC074308   EC074424   EC074566   EC076863   EC077866   EC078033   EC078926   EC079324   EC079364   EC079369   EC079434   EC080152   EC080907   EC081631   EC081755   EC082607   EC083925   EC084014   EC084338   EC084408   EC084727   EC085092   EC085272   EC085732   EC085823   EC086754   EC086845   EC087354   EC087977   EC088445   EC088528   EC088704   EC088732   EC088862   EC090394   EC090696   EC195733   EC195937   EC197016   EC197613   EC198187   EC198311   EC198357   EC198506   EC199653   EC199782   EC200005   EC200235   EC200668   EC200768   EC201294   EC201655   EC202104   EC202828   EC203106   EC203326   EC204139   EC204294   EC204635   EC204743   EC205095   EC205656   EC206276   EC207860   EC208421   EC209592   EC209842   EC210478   EC210574   EC211446   EC211674   EC212749   EC213851   EC215066   EC216306   EC218406   EC218452   EC218733   EC219554   EC220937   EC221185   EC222408   EC223051   EC223149   EC223443   EC223509   EC223550   EC225539   EC225659   EC225901   EC227047   EC228249   EC229456   EC230397   EC230552   EC231050   EC231181   EC231330   EC231499   EC232080   EC233454   EC233912   EC234027   EC234080   EC234163   EC234178   EC234311   EC234683   EC234782   EC234943   EC235703   EC235951   EC236575   EC236708   EC236782   EC236959   EC237247   EC237467   EC237483   EC237519   EC237567   EC237901   EC238243   EC239024   EC239703   EC239835   EC239836   EC239939   EC240864   EC241781   EC242186   EC242391   EC242875   EC244804   EC247144   EC247275   EC247713   EC248607   EC248918   EC249112   EC249159   EC249382   EC249450   EC249634   EC249821   EC250045   EC250676   EC251112   EC251538   EC251906   EC252112   EC256514   EC256690   EC256753   EC257326   EC257919   EC258099   EC259140   EC259252   EC259988   EC260485   EC261693   EC263438   EC263807   EC264648   EC264931   EC265696   EC266333   EC267351   EL870105   EL874865   EL874866   EL874994   EL875094   EL875095   EV575963   EV580596   EV584945   EV586564   EV587032   EV587637   EV589620   EV591571   EV594356   EV594384   EV595628   G00758   GH945866   GH947264   GH947313   GH947953   GH948117   GH950815   GH950817   GH951944   GH956606   GH957387   GH957551   GH959122   GH960122   GH960840   GH961351   GH961547   GH962186   GH962413   GH963374   GH964492   GH964906   GH965290   GH965672   GH966616   GH967498   GH968056   GH969927   GH970044   GH970695   GH970994   GH971247   GH971862   GH972749   GH974330   GH975067   GH976380   GH978015   GH979509   GH980968   GH981225   GH981276   GH981765   GH982614   GH983405   GH984601   U07606 AAA19592   U07607 AAA19593   U14401 AAA50836   Z97377
UniProtKB/Swiss-Prot	P42283 P42284 Q7KQZ4 Q867Z4 Q9V5M3 Q9V5M6
UniProtKB/TrEMBL	Q7JPL9 Q867Z4 Q8IGF5 Q95S45 Q95TA6 Q9V5M3 Q9V5M6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 17   central nervous system   (Giniger et al., 1994) embryonic stage 13 -- 17   histoblast   (Giniger et al., 1994) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   ventral furrow   (Goeke et al., 2003) Comment:lola probe N (lola-RP) embryonic stage 10   tracheal pit   (Goeke et al., 2003) Comment:lola probe J (lola-RU) cell | subset of ventral neurogenic region   (Goeke et al., 2003) Comment:lola probe C (lola-RL) embryonic stage 10 -- 11   mesectoderm   (Giniger et al., 1994) embryonic stage 10 -- 17   mesoderm   (Giniger et al., 1994) embryonic stage 11   mesoderm   (Goeke et al., 2003) Comment:lola probe L (lola-RB, lola-RC) amnioproctodeal invagination   (Goeke et al., 2003) Comment:lola probe L (lola-RB, lola-RC) cell of ectoderm   • apical part of cell (Goeke et al., 2003) Comment:lola probe J (lola-RU) embryonic stage 12 -- 14   presumptive embryonic/larval peripheral nervous system   (Giniger et al., 1994) embryonic stage 13   presumptive embryonic/larval central nervous system | restricted   (Goeke et al., 2003) Comment:lola probe I (lola-RF); enriched in dorsal cell layer of embryonic CNS embryonic stage 13 -- 17   embryonic imaginal precursor   (Giniger et al., 1994) embryonic stage 16   embryonic somatic muscle   (Goeke et al., 2003) Comment:lola probe L (lola-RB, lola-RC) embryonic epidermis   (Goeke et al., 2003) Comment:lola probe K (lola-RI) embryonic stage 16 -- 17   embryonic optic lobe primordium   (Giniger et al., 1994) embryonic/larval central nervous system   (Scully et al., 2002) embryonic stage 17   embryonic/larval central nervous system   (Goeke et al., 2003) Comment:lola probe K (lola-RI) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 15   organism   (Zhang et al., 2003) Comment:0-12 AEL
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system   (Giniger et al., 1994) tracheocyte   (Giniger et al., 1994) embryonic/larval somatic muscle   (Giniger et al., 1994) epithelial cell   (Giniger et al., 1994) central nervous system   (Giniger et al., 1994) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epithelial cell   (Giniger et al., 1994) embryonic/larval somatic muscle   (Giniger et al., 1994) central nervous system   (Giniger et al., 1994) presumptive embryonic/larval peripheral nervous system   (Giniger et al., 1994) tracheocyte   (Giniger et al., 1994) embryonic stage 3 -- 4   organism   • nucleus (Zhang et al., 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 17   organism   (Zhang et al., 2003) Comment:0-22 hr AEL organism   • nucleus (Zhang et al., 2003) Comment:0-22 hr AEL; different lola isoforms have different temporal distributions third instar larval stage     (Zhang et al., 2003) adult stage     (Zhang et al., 2003)
Additional Descriptive Data
	Multiple isoforms ofthe lola protein are detected throughout development. In late embryos up to 15 distinct bands can be detected on western blots using an antibody raised to the core BTB/Poz domain shared by all the predicted isoforms. (Zhang et al., 2003) lola protein distribution (as determined by an antibody that recognizes both protein forms) is consistent with lola transcript distribution but reveals new information. During gastrulation, the protein appears to turn over at mitosis. It is present at highest concentrations in neurons at stage 13 but is also present at substantial levels in epithelial cells and in sensory organ support cells. Unlike the RNA, lola protein is detected in mesodermal nuclei as late as stage 17. It is observed in somatic muscle and in peritracheal cells. (Giniger et al., 1994) lola protein distribution (as determined by an antibody that recognizes both protein forms) is consistent with lola transcript distribution but reveals new information. During gastrulation, the protein appears to turn over at mitosis. It is present at highest concentrations in neurons at stage 13 but is also present at substantial levels in epithelial cells and in sensory organ support cells. Unlike the RNA, lola protein is detected in mesodermal nuclei as late as stage 17. It is observed in somatic muscle and in peritracheal cells. (Giniger et al., 1994)
Marker for
Subcellular Localization
CV Term	nucleus (Giniger et al., 1994) nucleus (Giniger et al., 1994)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0005630    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0005630 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0005630 expression level Developmental Stage   Expression Level embryo 00-02hr    6104 embryo 02-04hr    9914 embryo 04-06hr    8088 embryo 06-08hr    6374 embryo 08-10hr    5768 embryo 10-12hr    4523 embryo 12-14hr    4069 embryo 14-16hr    4329 embryo 16-18hr    3132 embryo 18-20hr    2218 embryo 20-22hr    3423 embryo 22-24hr    2834 larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new    1500 white prepupae 12hr    1404 white prepupae 24hr    1739 pupae 2d postWPP    1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day    2152 adult female 05day    3308 adult female 30day    3393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6104) embryo 02-04hr  (9914) embryo 04-06hr  (8088) embryo 06-08hr  (6374) embryo 08-10hr  (5768) embryo 10-12hr  (4523) embryo 12-14hr  (4069) embryo 14-16hr  (4329) embryo 16-18hr  (3132) embryo 18-20hr  (2218) embryo 20-22hr  (3423) embryo 22-24hr  (2834) larva L1  (1038) larva L2  (686) larva L3 12hr old  (617) larva L3 puffstage 1-2  (554) larva L3 puffstage 3-6  (1189) larva L3 puffstage 7-9  (1199) white prepupae new  (1500) white prepupae 12hr  (1404) white prepupae 24hr  (1739) pupae 2d postWPP  (1588) pupae 3d postWPP  (919) pupae 4d postWPP  (907) adult male 01day  (886) adult male 05day  (969) adult male 30day  (1013) adult female 01day  (2152) adult female 05day  (3308) adult female 30day  (3393) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6104) embryo 02-04hr  (9914) embryo 04-06hr  (8088) embryo 06-08hr  (6374) embryo 08-10hr  (5768) embryo 10-12hr  (4523) embryo 12-14hr  (4069) embryo 14-16hr  (4329) embryo 16-18hr  (3132) embryo 18-20hr  (2218) embryo 20-22hr  (3423) embryo 22-24hr  (2834) larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new  1500 white prepupae 12hr  1404 white prepupae 24hr  (1739) pupae 2d postWPP  (1588) pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day  (2152) adult female 05day  (3308) adult female 30day  (3393) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6104 embryo 02-04hr    9914 embryo 04-06hr    8088 embryo 06-08hr    6374 embryo 08-10hr    5768 embryo 10-12hr    4523 embryo 12-14hr    4069 embryo 14-16hr    4329 embryo 16-18hr    3132 embryo 18-20hr    2218 embryo 20-22hr    3423 embryo 22-24hr    2834 larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new    1500 white prepupae 12hr    1404 white prepupae 24hr    1739 pupae 2d postWPP    1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day    2152 adult female 05day    3308 adult female 30day    3393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6104 embryo 02-04hr    9914 embryo 04-06hr    8088 embryo 06-08hr    6374 embryo 08-10hr    5768 embryo 10-12hr    4523 embryo 12-14hr    4069 embryo 14-16hr    4329 embryo 16-18hr    3132 embryo 18-20hr    2218 embryo 20-22hr    3423 embryo 22-24hr    2834 larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new    1500 white prepupae 12hr    1404 white prepupae 24hr    1739 pupae 2d postWPP    1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day    2152 adult female 05day    3308 adult female 30day    3393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0005630 expression level Developmental Stage   Expression Level embryo 00-02hr    6104 embryo 02-04hr    9914 embryo 04-06hr    8088 embryo 06-08hr    6374 embryo 08-10hr    5768 embryo 10-12hr    4523 embryo 12-14hr    4069 embryo 14-16hr    4329 embryo 16-18hr    3132 embryo 18-20hr    2218 embryo 20-22hr    3423 embryo 22-24hr    2834 larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new    1500 white prepupae 12hr    1404 white prepupae 24hr    1739 pupae 2d postWPP    1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day    2152 adult female 05day    3308 adult female 30day    3393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6104) embryo 02-04hr  (9914) embryo 04-06hr  (8088) embryo 06-08hr  (6374) embryo 08-10hr  (5768) embryo 10-12hr  (4523) embryo 12-14hr  (4069) embryo 14-16hr  (4329) embryo 16-18hr  (3132) embryo 18-20hr  (2218) embryo 20-22hr  (3423) embryo 22-24hr  (2834) larva L1  (1038) larva L2  (686) larva L3 12hr old  (617) larva L3 puffstage 1-2  (554) larva L3 puffstage 3-6  (1189) larva L3 puffstage 7-9  (1199) white prepupae new  (1500) white prepupae 12hr  (1404) white prepupae 24hr  (1739) pupae 2d postWPP  (1588) pupae 3d postWPP  (919) pupae 4d postWPP  (907) adult male 01day  (886) adult male 05day  (969) adult male 30day  (1013) adult female 01day  (2152) adult female 05day  (3308) adult female 30day  (3393) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6104) embryo 02-04hr  (9914) embryo 04-06hr  (8088) embryo 06-08hr  (6374) embryo 08-10hr  (5768) embryo 10-12hr  (4523) embryo 12-14hr  (4069) embryo 14-16hr  (4329) embryo 16-18hr  (3132) embryo 18-20hr  2218 embryo 20-22hr  (3423) embryo 22-24hr  (2834) larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new  1500 white prepupae 12hr  1404 white prepupae 24hr  1739 pupae 2d postWPP  1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day  2152 adult female 05day  (3308) adult female 30day  (3393) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6104 embryo 02-04hr    9914 embryo 04-06hr    8088 embryo 06-08hr    6374 embryo 08-10hr    5768 embryo 10-12hr    4523 embryo 12-14hr    4069 embryo 14-16hr    4329 embryo 16-18hr    3132 embryo 18-20hr    2218 embryo 20-22hr    3423 embryo 22-24hr    2834 larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new    1500 white prepupae 12hr    1404 white prepupae 24hr    1739 pupae 2d postWPP    1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day    2152 adult female 05day    3308 adult female 30day    3393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6104 embryo 02-04hr    9914 embryo 04-06hr    8088 embryo 06-08hr    6374 embryo 08-10hr    5768 embryo 10-12hr    4523 embryo 12-14hr    4069 embryo 14-16hr    4329 embryo 16-18hr    3132 embryo 18-20hr    2218 embryo 20-22hr    3423 embryo 22-24hr    2834 larva L1    1038 larva L2    686 larva L3 12hr old    617 larva L3 puffstage 1-2    554 larva L3 puffstage 3-6    1189 larva L3 puffstage 7-9    1199 white prepupae new    1500 white prepupae 12hr    1404 white prepupae 24hr    1739 pupae 2d postWPP    1588 pupae 3d postWPP    919 pupae 4d postWPP    907 adult male 01day    886 adult male 05day    969 adult male 30day    1013 adult female 01day    2152 adult female 05day    3308 adult female 30day    3393 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0005630    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0005630 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005630 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12052-RN;CG12052-RL;CG12052-RE;CG12052-RH;RH31485;CG12052-RF;CG12052-RS;CG12052-RQ;CG12052-RJ;CG12052-RI;CG12052-RM;CG12052-RK;CG12052-RG;CG12052-RC;CG12052-RP;CG12052-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for lola Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal lolaORE120 lethal, with Scer\GAL429BD lolaGS2074 lolaGS2091 lethal, with Scer\GAL41407 lolaGD4071 lolaGD6806 lolaGD9568 lolaKK110256 lethal, with Scer\GAL4c355 lolaGS2074 lolaGS2091 lethal, with Scer\GAL4GH146 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS lethal, with Scer\GAL4how-24B lola4.7.Scer\UAS lethal (with Df(2R)12) lola00642 lolaBM105 lolaBM119 lolaBM155 lolaBM157 lolaBM161 lolaTH8 lolaTH9 lolaTH12 lolaTH14 lolaTH26 lolaTH67 lolaTH68 lethal (with Df(2R)27) lolaBM105 lolaBM155 lolaBM157 lolaTH8 lolaTH14 lethal (with Df(2R)BSC595) lolaBM105 lolaBM155 lolaBM157 lolaTH8 lolaTH14 lethal (with Df(2R)E3363) lola00642 lethal (with Df(2R)ED2076) lolaBM105 lolaBM155 lolaBM157 lolaTH8 lolaTH14 lethal (with Df(2R)ED2098) lolaBM105 lolaBM155 lolaBM157 lolaTH8 lolaTH14 lethal (with Df(2R)stan2) lolac46 lolaORC4 lolaORE50 lolaORE119 lolaORE120 lethal (with lola5D2) lola629 lethal (with lola629) lola5D2 lola00642 lolaORC4 lolaORE50 lethal (with lola00642) lola629 lethal (with lolac46) lolaORE120 lethal (with lolaORC4) lola629 lolaORE50 lethal (with lolaORE50) lola629 lolaORC4 lethal (with lolaORE120) lolac46 lethal | partially (with lolac46) lolaORC4 lolaORE119 lethal | partially (with lolaORC4) lolac46 lolaORE120 lethal | partially (with lolaORE50) lolaORE120 lethal | partially (with lolaORE119) lolac46 lethal | partially (with lolaORE120) lolaORC4 lolaORE50 lethal | recessive lola1 lola1A4 lola2B13 lola4D4 lola4E4 lola5D2 lola00349 lola00482 lola00642 lola03078 lola03089 lola06218 lola06503 lola06686 lola06807 lola06808 lola07046 lola09972 lola10435 lolaBM105 lolaBM119 lolaBM155 lolaBM157 lolaBM161 lolac46 lolak00801 lolak03109 lolak03116 lolak03314 lolak10214 lolaORC4 lolaORE50 lolaORE119 lolaORE120 lolaP2 lolaP3 lolaP4 lolaP5 lolarH268 lolaTH8 lolaTH9 lolaTH12 lolaTH14 lolaTH26 lolaTH67 lolaTH68 semi-lethal lolas3697 semi-lethal, with Scer\GAL429BD lolaGS2055 semi-lethal, with Scer\GAL4c355 lolaGS2055 semi-lethal, with Scer\GAL4hs.2sev lolaGS2055 semi-lethal (with lola4E4) lola629 semi-lethal (with lola629) lola4E4 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 lolaGD4071 lolaGD6806 lolaGD9568 lolaGD9966 viable lolaEY10040 lolaT190-160 lolaT190-252 viable, with Scer\GAL4pnr-MD237 lolaGD9570 lolaGD9571 lolaGD9967 viable (with lola629) lolaORE120 viable (with lolac46) lolaORE50 viable (with lolaORC4) lolaORE119 viable (with lolaORE50) lolac46 lolaORE119 viable (with lolaORE119) lolaORC4 lolaORE50 lolaORE120 viable (with lolaORE120) lola629 lolaORE119 Sterility Allele fertile lolaEY10040 Other Phenotypes Allele behavior defective | recessive lolaBG02501 lolaBG02731 body color defective, with Scer\GAL4pnr-MD237 lolaGD9571 neuroanatomy defective lola1A4 lola4E4 lola5D2 lola00642 lola03089 lolac46 lolae76 lolaORB40 lolaORC4 lolaORC16 lolaORE50 lolaORE119 lolaORE120 neuroanatomy defective, with Scer\GAL4elav.PLu lola4.7.Scer\UAS neuroanatomy defective, with Scer\GAL4how-24B lola4.7.Scer\UAS neuroanatomy defective, with Scer\GAL4twi.PG lola4.7.Scer\UAS neuroanatomy defective (with lolac46) lolae76 neuroanatomy defective (with lolae76) lolac46 neuroanatomy defective | larval stage, with Scer\GAL41407 lolaGD4071 lolaGD6806 lolaGD9568 neuroanatomy defective | somatic clone lola5D2 lolae76 lolaORE119 neuroanatomy defective | somatic clone, with Scer\GAL4GH146 lolaL.Scer\UAS neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS neuroanatomy defective | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 neuroanatomy defective | somatic clone (with lolae76), with Scer\GAL4GH146 lolaL.Scer\UAS neuroanatomy defective | somatic clone (with lolaL.Scer\UAS), with Scer\GAL4GH146 lolae76 neuroanatomy defective | somatic clone | heat sensitive, with Scer\GAL4GH146 lola4.7.Scer\UAS visible, with Scer\GAL4dpp.blk1 lolaGS2055 lolaGS2074 lolaGS2091 visible, with Scer\GAL4hs.2sev lolaGS2055 lolaGS2091 visible, with Scer\GAL4pnr-MD237 lolaGD4071 lolaGD6806 lolaGD9568 visible, with Scer\GAL4sca-537.4 lolaEP343 wild-type, with Scer\GAL4elav.PLu lola3.8.Scer\UAS wild-type, with Scer\GAL4how-24B lola3.8.Scer\UAS wild-type, with Scer\GAL4hs.2sev lolaGS2074 wild-type, with Scer\GAL4twi.PG lola3.8.Scer\UAS Phenotype manifest in Allele A1-7 ventral longitudinal muscle 1 lola1A4 lolac46 lolae76 A1-7 ventral longitudinal muscle 2 lola1A4 lolac46 lolae76 A1-7 ventral longitudinal muscle 3 lola1A4 lolac46 lolae76 A1-7 ventral longitudinal muscle 4 lola1A4 lolac46 lolae76 abdominal 1 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 1 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal 2 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 2 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal 3 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 3 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal 4 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 4 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal 5 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 5 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal 6 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 6 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal 7 lateral monoscolopidial chordotonal organ lch1 lola2B13 lola5D2 abdominal 7 lateral pentascolopidial chordotonal organ lch5 lola2B13 lola5D2 abdominal intersegmental nerve lola2B13 lola5D2 abdominal segmental nerve lola1A4 lola5D2 lolac46 lolae76 lolag9 lolaunspecified abdominal segmental nerve, with Scer\GAL4elav.PLu lola4.7.Scer\UAS abdominal segmental nerve, with Scer\GAL4how-24B lola4.7.Scer\UAS abdominal segmental nerve, with Scer\GAL4twi.PG lola4.7.Scer\UAS adult antennal lobe projection neuron | heat sensitive | somatic clone, with Scer\GAL4GH146 lola4.7.Scer\UAS adult antennal lobe projection neuron | somatic clone lola5D2 lolae76 adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146 lolaL.Scer\UAS adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS adult antennal lobe projection neuron adPN | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 adult antennal lobe projection neuron DA1 vPN lolae76 adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS adult antennal lobe projection neuron DA1 vPN | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 adult antennal lobe projection neuron DL1 adPN | cell autonomous | somatic clone lolae76 adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS adult antennal lobe projection neuron DL1 adPN | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS adult antennal lobe projection neuron lPN | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 adult antennal lobe projection neuron VA1lm vPN | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 adult antennal lobe projection neuron VA1lm vPN | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 adult antennal lobe projection neuron VA1lm vPN | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS adult antennal lobe projection neuron VA1lm vPN | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 adult mushroom body | somatic clone lolae76 antennal lobe projection neuron adPN | cell autonomous | somatic clone lolae76 antennal lobe projection neuron lPN | cell autonomous | somatic clone lolae76 antennal lobe projection neuron vPN | cell autonomous | somatic clone lolae76 arista, with Scer\GAL4dpp.blk1 lolaGS2055 lolaGS2074 lolaGS2091 axon (with lolac46) lolae76 axon (with lolae76) lolac46 axon & adult antennal lobe projection neuron | somatic clone lola5D2 lolae76 axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146 lolaL.Scer\UAS axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolae76 lola4.7.Scer\UAS lolaL.Scer\UAS axon & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 axon & adult antennal lobe projection neuron | somatic clone | heat sensitive, with Scer\GAL4GH146 lola4.7.Scer\UAS axon & larval antennal lobe projection neuron | somatic clone | penetrance incomplete | expressivity incomplete | cell autonomous lolae76 central nervous system lola4E4 commissure lola2B13 lola5D2 dendrite & adult antennal lobe projection neuron | somatic clone lola5D2 lolae76 dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146 lolaL.Scer\UAS dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS dendrite & adult antennal lobe projection neuron | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 dendrite & adult antennal lobe projection neuron | somatic clone | heat sensitive, with Scer\GAL4GH146 lola4.7.Scer\UAS dendrite & larval antennal lobe projection neuron | somatic clone | penetrance incomplete | expressivity incomplete | cell autonomous lolae76 dorsal appendage | germline clone lola629 dorsocentral bristle, with Scer\GAL4sca-537.4 lolaEP343 egg chamber | germline clone lola00642 lola5D2 lola629 lolaORC4 lolaORE120 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 lolaGD4071 lolaGD6806 lolaGD9568 eye, with Scer\GAL4hs.2sev lolaGS2055 lolaGS2091 ganglion mother cell | larval stage, with Scer\GAL41407 lolaGD6806 lolaGD9568 gonad | embryonic stage (with lola22.05) lola46.38 gonad | embryonic stage (with lola46.38) lola22.05 gonadal sheath proper primordium | embryonic stage (with lola22.05) lola46.38 gonadal sheath proper primordium | embryonic stage (with lola46.38) lola22.05 intersegmental nerve lola1A4 lola5D2 lolac46 lolae76 lolag9 lateral horn | somatic clone lolae76 lateral horn | somatic clone, with Scer\GAL4GH146, lola3.8.Scer\UAS lolae76 lateral horn | somatic clone, with Scer\GAL4GH146, lola4.7.Scer\UAS lolae76 lateral horn | somatic clone, with Scer\GAL4GH146, lolae76 lola3.8.Scer\UAS lola4.7.Scer\UAS lolaL.Scer\UAS lateral horn | somatic clone, with Scer\GAL4GH146, lolaL.Scer\UAS lolae76 longitudinal connective lola03089 lola1 lola1A4 lola2B13 lola5D2 lolaB97 lolaORB40 lolaORC16 lolaORE120 lolaP2 lolaP3 lolaP4 lolaP5 lolac46 lolae76 lolag9 lolaunspecified macrochaeta lolaBG02501 lolaBG02731 lolaL47A mesothoracic tergum, with Scer\GAL4pnr-MD237 lolaGD4071 lolaGD6806 lolaGD9568 lolaGD9571 nurse cell | germline clone lola00642 lola5D2 lola629 lolaORC4 lolaORE120 presumptive embryonic/larval central nervous system lolaunspecified scutellar bristle, with Scer\GAL4sca-537.4 lolaEP343 synapse, with Scer\GAL4how-24B lola4.7.Scer\UAS synapse, with Scer\GAL4twi.PG lola4.7.Scer\UAS tormogen cell, with Scer\GAL4sca-537.4 lolaEP343 trichogen cell, with Scer\GAL4pnr-MD237 lolaGD4071 lolaGD9568 ventral longitudinal muscle lolaunspecified VUM1 neuron lola2B13 lola5D2 VUM2 neuron lola2B13 lola5D2 VUM3 neuron lola2B13 lola5D2 VUM4 neuron lola2B13 lola5D2 VUM5 neuron lola2B13 lola5D2 VUM6 neuron lola2B13 lola5D2
Classical Alleles ( 163 )
For All Classical Alleles Show
Allele of lola Class Mutagen Stocks Known lesion lolaEP2537 P-element activity 2 -- lolaKG09113 2 -- lola00642 P-element activity 1 Yes lola5-HA-1047 1 -- lola5-HA-1192 1 -- lola5-HA-2882 1 -- lola5-SZ-3170 1 -- lola5-SZ-3174 1 -- lola5D2 P-element activity 1 -- lolaA401 1 -- lolac01925 piggyBac transposase 1 -- lolaCB-5618-3 1 -- lolaCB-5647-3 1 -- lolaCB-5702-3 1 -- lolaCB-6036-3 1 -- lolad00683 P-element activity 1 -- lolad01398 P-element activity 1 -- lolad04250 P-element activity 1 -- lolad06440 P-element activity 1 -- lolad10062 P-element activity 1 -- lolae03977 piggyBac transposase 1 -- lolae76 chemical ethyl methanesulfonate 1 -- lolaEY08332 1 Yes lolaEY10040 P-element activity 1 Yes lolaf03899 piggyBac transposase 1 -- lolaf04767 piggyBac transposase 1 -- lolaf05488 piggyBac transposase 1 -- lolaGS5061 1 Yes lolak07402 P-element activity 1 -- lolak11603 P-element activity 1 -- lolaMB01619 1 -- lolaMI02077 1 -- lolaNP0275 1 -- lolaNP0338 1 -- lolaNP0678 1 -- lolaNP0990 1 -- lolaNP2422 1 -- lolaNP2540 1 -- lolaNP2754 1 -- lolaNP3146 1 -- lolaNP3317 1 -- lolaNP3354 1 -- lolaNP5162 1 -- lolaNP5274 1 -- lolaNP6245 1 -- lolaNP6555 1 -- lolaNP7358 1 -- lolaNP7393 1 -- lolaORC4 ethyl methanesulfonate 1 Yes lolaORE119 ethyl methanesulfonate 1 Yes lola00349 P-element activity 0 -- lola00482 P-element activity 0 Yes lola03078 P-element activity 0 -- lola03089 hypomorphic allele - genetic evidence P-element activity 0 -- lola06218 P-element activity 0 -- lola06503 P-element activity 0 -- lola06686 P-element activity 0 -- lola06807 P-element activity 0 -- lola06808 P-element activity 0 -- lola07046 P-element activity 0 -- lola09972 P-element activity 0 -- lola10435 P-element activity 0 -- lola1 ethyl methanesulfonate 0 -- lola1A4 hypomorphic allele - genetic evidence P-element activity 0 -- lola22.05 ethyl methanesulfonate 0 -- lola22112 0 -- lola226 P-element activity 0 Yes lola2B13 P-element activity 0 -- lola46.38 ethyl methanesulfonate 0 -- lola4D4 P-element activity 0 -- lola4E4 P-element activity 0 -- lola5-HA-2540 0 -- lola5-SZ-3182 0 -- lola6-4 Delta2-3 0 Yes lola629 ethyl methanesulfonate 0 Yes lolaA307 0 -- lolaB97 0 -- lolaBG02501 P-element activity 0 Yes lolaBG02731 P-element activity 0 Yes lolaBM105 ethyl methanesulfonate 0 -- lolaBM119 ethyl methanesulfonate 0 -- lolaBM155 ethyl methanesulfonate 0 -- lolaBM157 ethyl methanesulfonate 0 -- lolaBM161 ethyl methanesulfonate 0 -- lolac01926 piggyBac transposase 0 -- lolac46 chemical ethyl methanesulfonate 0 Yes lolaCB-0213-3 0 -- lolaCB-5287-3 0 -- lolaCB-6447-3 0 -- lolaCB-6914-3 0 -- lolaCB02888 0 -- lolaCPTI000190 piggyBac transposase 0 Yes lolaCPTI001872 piggyBac transposase 0 Yes lolad01743 P-element activity 0 -- lolad02691 P-element activity 0 -- lolad03803 P-element activity 0 -- lolad04190 P-element activity 0 -- lolad06620 P-element activity 0 -- lolad09425 P-element activity 0 -- lolae00140 piggyBac transposase 0 -- lolaeAK4 ethyl methanesulfonate 0 -- lolaeCF3 X ray 0 -- lolaeCQ1 ethyl methanesulfonate 0 -- lolaeDZ6 ethyl methanesulfonate 0 -- lolaeES2a-spont spontaneous 0 -- lolaEP2071 0 -- lolaEP2106 P-element activity 0 -- lolaEP2137 P-element activity 0 -- lolaEP2321 P-element activity 0 -- lolaEP2374 P-element activity 0 -- lolaEP2396 P-element activity 0 -- lolaEP2398 P-element activity 0 -- lolaEP2626 P-element activity 0 -- lolaEP2636 P-element activity 0 -- lolaEP343 P-element activity 0 Yes lolaEP354 P-element activity 0 -- lolaEP451 P-element activity 0 -- lolaEP952 P-element activity 0 -- lolag9 chemical 0 -- lolaGS-A916 Delta2-3 0 -- lolaGS2055 Delta2-3 0 Yes lolaGS2074 Delta2-3 0 Yes lolaGS2091 Delta2-3 0 Yes lolaGS88A8 0 Yes lolaGS9705 0 -- lolak00801 P-element activity 0 -- lolak01012 P-element activity 0 -- lolak02708 P-element activity 0 -- lolak03001 P-element activity 0 -- lolak03109 P-element activity 0 -- lolak03116 P-element activity 0 -- lolak03314 P-element activity 0 -- lolak10214 P-element activity 0 -- lolaL47A P-element activity 0 Yes lolamig5D 0 -- lolaNP4216 0 -- lolaNP4268 0 -- lolaNP4743 0 -- lolaNP4758 0 -- lolaORB40 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- lolaORC16 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- lolaORE120 ethyl methanesulfonate 0 Yes lolaORE50 ethyl methanesulfonate 0 Yes lolaP2 P-element activity 0 -- lolaP3 P-element activity 0 -- lolaP4 P-element activity 0 -- lolaP5 P-element activity 0 -- lolarE028 P-element activity 0 -- lolarev6 ethyl methanesulfonate 0 Yes lolarH268 P-element activity 0 -- lolas3697 P-element activity 0 -- lolaT190-160 P-element activity 0 Yes lolaT190-252 P-element activity 0 Yes lolaTH12 ethyl methanesulfonate 0 -- lolaTH14 ethyl methanesulfonate 0 -- lolaTH26 ethyl methanesulfonate 0 -- lolaTH67 ethyl methanesulfonate 0 -- lolaTH68 ethyl methanesulfonate 0 -- lolaTH8 ethyl methanesulfonate 0 -- lolaTH9 ethyl methanesulfonate 0 -- lolaUM-8062-3 0 -- lolaunspecified 0 -- lolaΔ18 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lola Class Mutagen Stocks Known lesion lola4.7.Scer\UAS in vitro construct - regulatory fusion 2 Yes lolaGD4071 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lolaGD9568 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lolaGD9570 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lolaGD9966 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes lola3.8.Scer\UAS in vitro construct - regulatory fusion 1 Yes lolaGD6806 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lolaGD9571 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lolaGD9967 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lolaGLV21086 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lolaJF02254 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lolaKK110256 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lolaL.Scer\UAS in vitro construct - regulatory fusion 1 Yes loladsRNA.cIa in vitro construct - RNAi 0 Yes loladsRNA.cRa in vitro construct - RNAi 0 Yes lolaGD5781 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes lolalong.Act5C in vitro construct - regulatory fusion 0 Yes lolashort.Act5C in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)12 (Weber et al., 1995, Strub et al., 2008, Otte et al., 2009) Df(2R)17 (Weber et al., 1995) Df(2R)27 (Weber et al., 1995, Otte et al., 2009) Df(2R)47A (Fremion et al., 1999) Df(2R)BSC595 (Christensen et al., 2008.9.3, Otte et al., 2009) Df(2R)E3363 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Strub et al., 2008) Df(2R)ED2076 (Otte et al., 2009) Df(2R)ED2098 (Otte et al., 2009) Df(2R)stan1 (Paige Bass et al., 2007) Df(2R)stan2 (Spradling et al., 1999, Horiuchi et al., 2003, BDGP Project Members, 1994-1999) Df(2R)Δ18 (Berg, 1996.2.28, Horowitz and Berg, 1996)
Not disrupted in	Df(2R)BSC281 (Otte et al., 2009) Df(2R)X1 (Otte et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4071} NA P{GD5781} NA P{GD6806} NA P{GD9568} NA P{GD9570} NA P{GD9571} NA P{GD9966} NA P{GD9967} NA P{KK110256} NA P{TRiP.GLV21086} NA P{TRiP.JF02254} NA P{UAS-lola.3.8} NA P{UAS-lola.4.7} NA P{UAS-lola.L} NA reporter construct P{lola-lacZ.In30-3077} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP860 NA P{EP}EP2038 NA P{EP}lolaEP343 NA P{EP}lolaEP354 NA P{EP}lolaEP451 NA P{EP}lolaEP952 NA P{EP}lolaEP2071 NA P{EP}lolaEP2106 NA P{EP}lolaEP2137 NA P{EP}lolaEP2321 NA P{EP}lolaEP2374 NA P{EP}lolaEP2396 NA P{EP}lolaEP2398 NA P{EP}lolaEP2537 NA P{EP}lolaEP2626 NA P{EP}lolaEP2636 NA P{EPgy2}lolaEY08332 NA P{EPgy2}lolaEY10040 NA P{GSV1}GSd429GSd429 NA P{GSV1}GSd434GSd434 NA P{GSV1}lolaGS88A8 NA P{GSV1}lolaGS2055 NA P{GSV1}lolaGS2074 NA P{GSV1}lolaGS2091 NA P{GSV1}lolaGS-A916 NA P{GSV2}lolaGS5061 NA P{GSV6}lolaGS9705 NA P{XP}lolad00683 NA P{XP}lolad01398 NA P{XP}lolad01743 NA P{XP}lolad02691 NA P{XP}lolad03803 NA P{XP}lolad04190 NA P{XP}lolad04250 NA P{XP}lolad06440 NA P{XP}lolad06620 NA P{XP}lolad09425 NA P{XP}lolad10062 NA insertion of enhancer trap P{lacW}l(2)SH0263SH0263 No P{lacW}lola1A4 No P{lacW}lola2B13 No P{lacW}lola4D4 No P{lacW}lola4E4 No P{lacW}lola5D2 No P{lacW}lolak00801 No P{lacW}lolak01012 No P{lacW}lolak02708 No P{lacW}lolak03001 No P{lacW}lolak03109 No P{lacW}lolak03116 No P{lacW}lolak03314 No P{lacW}lolak07402 No P{lacW}lolak10214 No P{lacW}lolak11603 No P{lacW}lolaP2 No P{lacW}lolaP3 No P{lacW}lolaP4 No P{lacW}lolaP5 No P{lacW}lolas3697 No P{lArB}lolaL47A No P{luc-sniffer}lola6-4 No P{PZ}lola00349 No P{PZ}lola00482 No P{PZ}lola00642 No P{PZ}lola03078 No P{PZ}lola03089 No P{PZ}lola06218 No P{PZ}lola06503 No P{PZ}lola06686 No P{PZ}lola06807 No P{PZ}lola06808 No P{PZ}lola07046 No P{PZ}lola09972 No P{PZ}lola10435 No P{PZ}lolarE028 No P{PZ}lolarH268 No miscellaneous insertions Mi{MIC}lolaMI02077 NA P{GT1}lolaBG02501 NA P{GT1}lolaBG02731 NA P{luc+.GFP}lola226 NA P{PTT-GB}lolaCB02888 NA P{RS3}lolaCB-0213-3 NA P{RS3}lolaCB-5287-3 NA P{RS3}lolaCB-5618-3 NA P{RS3}lolaCB-5647-3 NA P{RS3}lolaCB-5702-3 NA P{RS3}lolaCB-6036-3 NA P{RS3}lolaCB-6447-3 NA P{RS3}lolaCB-6914-3 NA P{RS3}lolaUM-8062-3 NA P{RS5}lola5-HA-1047 NA P{RS5}lola5-HA-1192 NA P{RS5}lola5-HA-2540 NA P{RS5}lola5-HA-2882 NA P{RS5}lola5-SZ-3170 NA P{RS5}lola5-SZ-3174 NA P{RS5}lola5-SZ-3182 NA P{SUPor-P}lolaKG09113 NA P{T1}lolaT190-160 NA P{T1}lolaT190-252 NA PBac{5HPw+}lolaA401 NA PBac{602.P.SVS-1}lolaCPTI000190 NA PBac{681.P.FSVS-1}lolaCPTI001872 NA PBac{PB}lolac01925 NA PBac{PB}lolac01926 NA PBac{RB}lolae00140 NA PBac{RB}lolae03977 NA PBac{WH}lolaf03899 NA PBac{WH}lolaf04767 NA PBac{WH}lolaf05488 NA insertion of enhancer trap binary system Mi{ET1}lolaMB01619 No P{GawB}lolaNP0275 No P{GawB}lolaNP0338 No P{GawB}lolaNP0678 No P{GawB}lolaNP0990 No P{GawB}lolaNP2422 No P{GawB}lolaNP2540 No P{GawB}lolaNP2754 No P{GawB}lolaNP3146 No P{GawB}lolaNP3317 No P{GawB}lolaNP3354 No P{GawB}lolaNP4216 No P{GawB}lolaNP4268 No P{GawB}lolaNP4743 No P{GawB}lolaNP4758 No P{GawB}lolaNP5162 No P{GawB}lolaNP5274 No P{GawB}lolaNP6245 No P{GawB}lolaNP6555 No P{GawB}lolaNP7358 No P{GawB}lolaNP7393 No P{M2ET-QF}ET8 No
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with JIL-1 (Zhang et al., 2003)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) axon guidance inferred from genetic interaction with SoxN (Girard et al., 2006) inferred from mutant phenotype (Giniger et al., 1994, Crowner et al., 2002) axon midline choice point recognition inferred from genetic interaction with robo AND inferred from genetic interaction with sli AND inferred from mutant phenotype (Crowner et al., 2002) axonogenesis inferred from mutant phenotype (Giniger et al., 1994) brain morphogenesis inferred from mutant phenotype (Yamamoto et al., 2008) gonad development inferred from mutant phenotype (Weyers et al., 2011) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) locomotion involved in locomotory behavior inferred from mutant phenotype (Yamamoto et al., 2008) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) nurse cell apoptosis inferred from mutant phenotype (Paige Bass et al., 2007) R3/R4 cell fate commitment inferred from mutant phenotype (Zheng and Carthew, 2008) R7 cell development inferred from mutant phenotype (Zheng and Carthew, 2008) regulation of transcription, DNA-dependent inferred from mutant phenotype (Zheng and Carthew, 2008) startle response inferred from mutant phenotype (Yamamoto et al., 2008)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Giniger et al., 1994, Zhang et al., 2003)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with ttk (Giniger et al., 1994) non-traceable author statement (Madden and Giniger, 1996) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
axon guidance non-traceable author statement (Swiss-Prot Project Members, 1995.6.1, Swiss-Prot Project Members, 1995.6.1) positive regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:Q08605 (Giniger et al., 1994) regulation of transcription from RNA polymerase II promoter non-traceable author statement (Zhong, 1997.7.8)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Madden and Giniger, 1996, Swiss-Prot Project Members, 1995.6.1, Swiss-Prot Project Members, 1995.6.1)
Sequence Ontology: Class of Gene
	gene_with_trans_spliced_transcript (Horiuchi et al., 2003, ) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lola allele Gene References lola00642 JIL-1 (Zhang et al., 2003) lolaeAK4 N (Verheyen et al., 1996) lolaeCF3 N (Verheyen et al., 1996) lolaeCQ1 N (Verheyen et al., 1996) lolaeDZ6 N (Verheyen et al., 1996) lolaeES2a-spont N (Verheyen et al., 1996) lolaORE120 robo (Crowner et al., 2002) sli (Crowner et al., 2002) unspecified ct (Krupp et al., 2005) H (Mueller et al., 2005) Nsf2 (Laviolette et al., 2005) pbl (Gregory et al., 2007) SoxN (Girard et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69126 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005630 DroID - A comprehensive database of gene and protein interactions. • FBgn0005630 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44548
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11096 Dgri\GH20621 Dvir\GJ20132 Dwil\GK10673
Curated drosophilid orthologs	Dpse\GA11362   Dpse\lola (Ohsako et al., 2003) Dyak\GE13100 (Domazet-Loso, 2003.2.7)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009212-PC Aedes aegypti (mosquito) AGAP005245-PA Anopheles gambiae (mosquito) XP_001947442.1 Acyrthosiphon pisum (pea aphid) 124280 Branchiostoma floridae (lancelet) ENSBTAP00000015819 Bos taurus (bovine) ENSCAFP00000015939 Canis familiaris (dog) CPIJ015575 Culex pipens (mosquito) 327185 Daphnia pulex (daphnia) ENSGALP00000036650 Gallus gallus (chicken) ENSP00000377375 Homo sapiens (human) ENSMMUP00000039977 Macaca mulatta (rhesus monkey) ENSOANP00000007813 Ornithorynchus anatinus (platypus) PHUM005349-PA Pediculus humanus (human body louse) ENSPPYP00000015124 Pongo pygmaeus (orangutan) ENSPTRP00000057214 Pan troglodytes (chimpanzee) XP_976063.2 Tribolium castaneum (red flour beetle) ENSTNIP00000020015 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000004071 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000045910 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230794 FBgn0212687 FBgn0207272 FBgn0197247 FBgn0175393 FBgn0246413 FBgn0154795 FBgn0142917 FBgn0128084 FBgn0114898 CPIJ015576
Stocks & Reagents
Stocks Listed in FlyBase ( 70 )
Bloomington	28830 P{UAS-lola.3.8}1, w*
Harvard	- P{XP}lolad00683 - P{XP}lolad01398 - P{XP}lolad04250 - P{XP}lolad06440 - P{XP}lolad10062 - PBac{PB}lolac01925 - PBac{RB}lolae03977 - PBac{WH}lolaf03899 - PBac{WH}lolaf04767 - PBac{WH}lolaf05488
VDRC	v101925 P{KK110256}VIE-260B
	More stocks available...
Genomic Clones ( 3 )
	BACR16P22 BACR20O22 BACR31I21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 779 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08307 GM09276 IP14843 LD03274 LD17006 LD28033 RH31485
Other clones	DPiM_LD03274 FI13033 MIP27406
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02260 AT10633 AT13672 GH26036 GM01623 GM01643 GM08066 GM27815 HL01231 HL03227 LD01566 LD02175 LD03746 LD08889 LD10027 LD13275 LD13426 LD14532 LD15437 LD15629 LD17361 LD18177 LD19255 LD19374 LD19487 LD20937 LD24002 LD32806 LD34018 LD36061 LD39046 LD40581 LD42824 LD43271 LD45467 LD45866 LD47894 LP19536 RE02194 RE03521 RE03571 RE04569 RE05623 RE05909 RE08805 RE08950 RE09586 RE10446 RE11418 RE12913 RE13371 RE14556 RE16278 RE16350 RE16890 RE17103 RE18733 RE20586 RE20670 RE21496 RE22770 RE23049 RE24306 RE26141 RE26321 RE27134 RE27189 RE27745 RE28043 RE28176 RE28724 RE29316 RE30035 RE31306 RE35045 RE35381 RE35568 RE35680 RE36510 RE37413 RE38317 RE40288 RE42111 RE43638 RE44816 RE45442 RE47635 RE47892 RE48068 RE49127 RE49546 RE50446 RE52685 RE52909 RE53180 RE54231 RE57275 RE58188 RE58234 RE58245 RE59061 RE60325 RE60405 RE61185 RE61447 RE63510 RE63816 RE66513 RE67687 RE68451 RE69952 RE72764 RE74588 RH03363 RH22140 RH27572 RH47341 RH71691 RH72881 SD06588 SD07909 SD14435 SD19238 SD22010 SD24011
Other clones	117 7174 10391 12669 13467 16595 16924 17991 20120 20907 28146 28776 28931 29490 29728 30813 31031 31235 31239 33319 33869 34214 34345 34466 35823 36976 38063 38324 39487 39787 39844 42176 42678 43805 44673 45490 45892 45986 46794 47385 47598 50969 51682 52666 54615 56442 56500 57798 57939 57967 59083 59359 59444 59450 60302 60937 61625 61636 62440 62982 63052 63784 65171 73471 73525 74090 74206 74471 74480 75412 76055 76228 77062 79719 82031 83173 98471 99607 101185 102201 102777 103876 104209 105122 105536 105649 107087 107767 108163 108660 118525 118652 118765 118916 119427 119682 120028 120596 120611 120631 125359 125595 144375 144383 144406 144408 146159 146941 148162 149231 155729 156194 156869 159295 160873 161039 162315 163477 164409 165590 166245 175311 177220 181528 190748 191709 192016 192142 192238 193441 211204 214217.47 214311.40 214321.35 214381.42 214383.45 214413.40 214415.44 214435.45 214477.40 214533.45 214537.51 214541.29 214541.30 274613 275269 277704 280461 280611 281090 281107 281479 281504 281575 282829 283438 522200 523150 523737 524157 525018 533576 569832 572942 bs06a08 bs39c08 CK01.6C.F12 CK01.14B.D8 CK01.22B.D6 CK01.29C.G3 CK01.31D.G4 CK01.44B.F6 CK01.53B.G3 CK01.53B.H10 CK01.61A.H8 CK01.61C.C9 CK01.63D.A8 CK01.64D.B12 CK01.66C.E10 CK01.66D.F4 CK01.77A.C2 CK01.78D.A10 CK01.79C.C8 CK01.79C.E2 CK01.80B.G10 CK01.84B.F8 CK01.89B.F5 CK01.91A.D7 CK01.91C.H10 CK01.94D.G7 CK01.96B.F7 CK01.96D.C10 CK01.98B.C5 CK01.100A.D1 CK01.101B.F6 CK01.104A.D1 CK01.106B.E3 CK01.110C.G2 CK01.113B.G9 CK01.124C.H4 CK01.145B.H10 CK01.167C.A2 CK01.169B.D1 Dmel_dig_000977_0638_0327 Dmel_dig_013625_0612_3426 Dmel_dig_019568_0598_1208 Dmel_neb_008934_0678_2283 Dmel_neb_009564_0703_0981 Dmel_neb_010107_0179_3490 Dmel_neb_011831_0170_0850 Dmel_neb_012316_0363_0708 Dmel_neb_013336_0573_2332 Dmel_neb_014289_0390_3514 Dmel_neb_014677_0164_3485 EC053266 EK002720 EK027458 EK042963 EK043026 EK048411 EK051936 EK056102 EK061326 EK061744 EK061749 EK062159 EK063764 EK064036 EK065140 EK068856 EK070118 EK070202 EK071316 EK071761 EK075043 EK076011 EK084610 EK085455 EK088718 EK090152 EK100943 EK102311 EK103033 EK103813 EK105214 EK115445 EK125320 EK130210 EK133309 EK135755 EK137254 EK137533 EK140124 EK140132 EK140315 EK141264 EK141501 EK147951 EK148611 EK148862 EK149336 EK150758 EK150946 EK156360 EK156404 EK159124 EK159242 EK160020 EK161256 EK161727 EK161756 EK163306 EK163713 EK164219 EK164752 EK166154 EK166658 EK168005 EK168514 EK168619 EK169534 EK169549 EK171121 EK173104 EK173857 EK175424 EK176530 EK177214 EK178556 EK180051 EK183829 EK185737 EK186762 EK187523 EK188643 EK188652 EK190562 EK192501 EK194008 EK196002 EK201205 EK204248 EK207319 EK215464 EK215602 EK216834 EK221253 EK222318 EK223858 EK224749 EK227749 EK227902 EK229982 EK230531 EK231034 EK233121 EK234175 EK234746 EK234807 EK235147 EK235739 EK237956 EK238255 EK238836 EK240321 EK240639 EK242306 EK242839 EK247528 EK247542 EK249519 EK250323 EK250339 EK250650 EK250654 EK251023 EK253654 EK254613 EK258956 EK259255 EK259832 EK264819 EK265714 EK267610 EK268664 EK270357 EK274340 EK290412 EK291735 EK291745 EK292162 EK293014 EK294521 EK294609 EK294657 EK295056 EK302005 EK302341 EK303225 EK304538 EK305334 EK305424 EK306253 EK306352 EK306733 EK307033 EK307116 EK308529 EK308814 EN01541 EN04851 EN06348 EN09761 EN11309 EN15715 EN17544 EP00850 EP03064 EP03116 EP05054 EP05642 EP06743 EP07943 EP10256 EP10531 EP11423 EP14534 ESG0114b.B21_H02 FGA005C02 FGA009G10 FGC024E09 FGH112H10 FGH114C12 FGM003F05 FGM004A03 FGM232B02 FGM233F06 FGM234H02 FGM302G01 FGM309B08 FGM313D07 FGM316E01 FGM321F06 HL01413 IP02213 IP14943 IP15043 IP15143 LD02442 LD02668 LD02820 LD03126 LD03596 LD04051 LD05301 LD05516 LD05991 LD07743 LD08209 LD08366 LD09608 LD10818 LD11026 LD11231 LD11423 LD11472 LD11585 LD11722 LD12219 LD12608 LD12649 LD12680 LD13249 LD13259 LD13754 LD14029 LD14035 LD14150 LD14228 LD15021 LD15136 LD15869 LD16572 LD16608 LD17144 LD17659 LD18670 LD19328 LD19747 LD19966 LD20602 LD24652 LD24948 LD28473 LD28979 LD29968 LD31218 LD32052 LD32174 LD32743 LD33265 LD33469 LD33478 LD33951 LD34266 LD34566 LD34694 LD38843 LD41517 LP11590 LP11910 RE01491 RE01754 RE03355 RE03901 RE03960 RE04728 RE06280 RE06624 RE07676 RE07789 RE07942 RE08461 RE09765 RE11115 RE11369 RE11761 RE11910 RE12134 RE13218 RE13352 RE13480 RE13934 RE14256 RE14524 RE16110 RE16348 RE16559 RE16753 RE16781 RE17319 RE17572 RE18279 RE18335 RE18820 RE18824 RE19394 RE19843 RE20534 RE20872 RE21358 RE21654 RE21702 RE21727 RE21785 RE21895 RE22069 RE22270 RE23020 RE23841 RE25639 RE25896 RE25993 RE26345 RE27276 RE29672 RE30292 RE30815 RE30845 RE30887 RE31378 RE32628 RE33701 RE33851 RE33910 RE34216 RE34918 RE35533 RE35539 RE35559 RE36190 RE36407 RE37133 RE37812 RE37859 RE38987 RE39516 RE39953 RE40005 RE40566 RE42264 RE42795 RE42953 RE43255 RE44508 RE44517 RE44733 RE44869 RE45279 RE45480 RE46786 RE47617 RE47870 RE47890 RE48456 RE48526 RE50485 RE52503 RE52804 RE55773 RE56222 RE58677 RE60733 RE61302 RE62005 RE62193 RE64029 RE64101 RE64848 RE65047 RE65342 RE65938 RE67486 RE69271 RE69489 RE70683 RE71369 RE74460 RH04208 RH05066 RH07001 RH21623 RH22491 RH41437 RH52980 RH57161 RH58549 RH72426 RP004012791 RP004056335 RP004059877 RP004075470 RP004151701 RP004163590 RP004168264 RP004196582 RP004201918 RP004203247 RP004210310 RP004210925 RP004211681 RP004219078 RP004225544 RP004228083 RP004233377 RP004234570 RP004236331 RP004249591 RP004264520 RP004320683 RP004350671 RP004365725 RP004392946 RP004406256 RP004415402 RP004419210 RP004423781 RP004432543 RP004434932 RP004460001 RP004466587 RP004477679 RP004488395 RP004494151 RP004498204 RP004503018 RP004515412 RP004525679 RP004528133 RP004533428 RP004536216 RP004541984 RP004549054 UUGC0394
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005630 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44548
Antibody Information
	polyclonal (Zhang et al., 2003, Giniger et al., 1994, Giniger et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: lola BcDNA:RH31485 (FlyBase, 1996-) Source for merge of: lola BtbIV (FlyBase, 1996-) Source for merge of: lola CG12052 CG18376 (Bayraktaroglu, 2000.4.12) Source for merge of: lola CG18378 CG18379 CG18380 CG18381 (FlyBase Genome Annotators, 2002-2003) Source for merge of: lola l(2)s3697 (Beaton, 1999.12.12) Source for merge of: lola NEST:bs06a08 (FlyBase, 1996-) Source for merge of: lola sw59 BEST:LD03274 (Bayraktaroglu, 2000.11.2)
Additional comments	snoRNA:lola-a, snoRNA:lola-b, snoRNA:lola-c and snoRNA:lola-d are encoded in an intron of lola. (Graveley et al., 2011) FlyBase curator comment: FBrf0194763 states that "btb[k09901]" is an allele of the "lola" gene, based on the failure of "btb[k09901]" to complement lola[00642], lola[5D2], lola[ORC4], lola[ORE50], lola[4E4] and lola[ORE120]. However, FBrf0131381 states that "btb[k09901]" complements lola[5D2] and lola[A307]. Due to this conflicting complementation data, and due to the fact that there is also conflicting data about the localisation of the insertion in "btb[k09901]", depending on whether in situ or flanking sequence data is used (see FBrf0131381), the "btb[k09901]" allele and parent "btb" gene have been kept separate from the "lola" gene in FlyBase until more information is available to resolve these conflicts (date: 100104). (Paige Bass et al., 2007) Source for merge of: lola BcDNA:LD17006 (Ferres-Marco et al., 2006, FlyBase, 1996-) Annotations CG18376, CG18381, CG18380, CG18379, CG18378 and CG12052 merged as CG12052 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of lola BtbIV was sequence comparison (date:000202). (FlyBase, 1996-) Source for merge of lola BcDNA:LD17006 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli when assayed in S2 cells. (Kleino et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) lola mRNAs are generated by alternative trans-splicing. (Horiuchi et al., 2003) Identification: as a suppressor of the small eye phenotype caused by overexpression of fng in the eye. (Ferres-Marco and Dominguez, 2001) 'eyeful' mutant interacts genetically with N and fng though it is not yet clear whether 'eyeful' corresponds to lola or psq. (Ferres-Marco and Dominguez, 2001) Five EMS induced alleles have been identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Homozygous germline clones have not been recovered. lola may perform some essential function in the germline during oogenesis. (Madden et al., 1999) lola is required for required for pathfinding and targeting of the SNb motor nerve. lola is a dose dependant regulator of SNb development. (Madden et al., 1999) Identification: Enhancer trap screen designed to discover genes involved in the cellular aspects of defense mechanisms, as well as in melanotic tumor formation processes linked to blood cell disregulation. (Braun et al., 1997) Dhyd\lola-like is structurally related to lola. (Cavarec et al., 1997) lola encodes a transcription factor required for axon growth and guidance in the embryo. (Giniger et al., 1994) In lola mutant embryos growth cones that normally pioneer longitudinal pathways initially extend but then stall, thereby lacking most longitudinal axon pathways. (Goodman et al., 1993) Mutations lack longitudinal connectives of embryonic ventral nerve cord. (Seeger et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080027 NM_170617 NM_170618 NM_170619 NM_170620 NM_170621 NM_170622 NM_170623 NM_176128 NM_176129 NM_176130 NM_176131 NM_176132 NM_176133 NM_176134 NM_176135 NM_176136 NM_176137 NM_176138 NM_176139 NM_176140 NM_206082 NM_206083 NM_206084 NM_206085 NM_001032229 RefSeq (Proteins) • NP_524766 NP_724945 NP_724946 NP_724949 NP_724950 NP_724951 NP_724952 NP_724953 NP_788308 NP_788309 NP_788310 NP_788311 NP_788312 NP_788313 NP_788314 NP_788315 NP_788316 NP_788317 NP_788318 NP_788319 NP_788320 NP_995804 NP_995805 NP_995806 NP_995807 NP_001027400 DDBJ / EMBL / GenBank • AA390332 AA390681 AA438870 AA441086 AA536406 AA536597 AA697178 AA949220 AA979185 AAA19592 AAA19593 AAA50836 AAF58773 AAF58773.1 AAF58775 AAF58775.3 AAF58776 AAF58776.2 AAF58777 AAF58777.2 AAF58778 AAF58778.3 AAF58778.4 AAF58779 AAF58779.2 AAF58779.3 AAF58781 AAF58781.2 AAF58781.3 AAF58782 AAF58782.2 AAL13815 AAL25295 AAL28511 AAM27509 AAM68764 AAM68764.2 AAM68764.3 AAM68765 AAM68765.1 AAM68766 AAM68766.1 AAM68767 AAM68767.2 AAM68768 AAM68768.2 AAN71562 AAO41424 AAO41424.1 AAO41424.2 AAO41425 AAO41425.1 AAO41426 AAO41426.1 AAO41427 AAO41427.1 AAO41428 AAO41428.1 AAO41429 AAO41429.1 AAO41430 AAO41430.1 AAO41431 AAO41431.1 AAO49162 AAS64874 AAS64874.1 AAS64875 AAS64875.1 AAS64876 AAS64876.1 AAS64877 AAS64877.1 AAZ52818 AB107272 AB107273 AB107274 AB107275 AB107276 AB107277 AB107278 AB107279 AB107280 AB107281 AB107282 AB107283 AB107284 AB107285 AB107286 AB107287 AB107288 AB107289 AB107290 AB107291 AB107292 AB107293 AB107294 AB107295 AB107296 AB107297 AB107298 AB107299 AB107300 AB107301 AB107302 AB107303 AB107304 AB107305 AB107306 AB107307 AB107308 AB107309 AB107310 AB107311 AB107312 AB107313 AB107314 AB107315 AB107316 AB107317 AB107318 AB107319 AB107320 AB107321 AB107322 AB107323 AB107324 AB107325 AB107326 AB107327 AB107328 AB107329 AB107330 AB107331 AB107332 AB107333 AB107334 AB107335 AB107336 AB107337 AB107338 AB107339 AB107340 AB107341 AB107342 AB107343 AB107344 AB107345 AB107346 AB107347 AB107348 AB107349 AB107350 AB107351 AI109185 AI944838 AQ024998 AQ025981 AQ026006 AQ072907 AQ072929 AQ073258 AQ073490 AQ073534 AQ073552 AQ073670 AQ073738 AQ073746 AQ073747 AQ254790 AQ254857 AW940296 AW941966 AW942043 AW942437 AW942791 AY058586 AY060256 AY060963 AY102680 BAC67577 BAC67578 BAC67579 BAC67580 BAC67581 BAC67582 BAC67583 BAC67584 BAC67585 BAC67586 BAC67587 BAC67588 BAC67589 BAC67590 BAC67591 BAC67592 BAC67593 BAC67594 BAC67595 BAC67596 BAC67597 BAC67598 BAC67599 BAC67600 BAC67601 BAC67602 BAC67603 BAC67604 BAC67605 BAC67606 BAC67607 BAC67608 BAC67609 BAC67610 BAC67611 BAC67612 BAC67613 BAC67614 BAC67615 BAC67616 BAC67617 BAC67618 BAC67619 BAC67620 BAC67621 BAC67622 BAC67623 BAC67624 BAC67625 BAC67626 BAC67627 BAC67628 BAC67629 BAC67630 BAC67631 BAC67632 BAC67633 BAC67634 BAC67635 BAC67636 BAC67637 BAC67638 BAC67639 BAC67640 BAC67641 BAC67642 BAC67643 BAC67644 BAC67645 BAC67646 BAC67647 BAC67648 BAC67649 BAC67650 BAC67651 BAC67652 BAC67653 BAC67654 BAC67655 BAC67656 BG638710 BI354668 BI575699 BT001807 BT004909 CL610266 CZ467549 CZ467550 CZ471740 CZ472208 CZ472414 CZ472415 CZ472946 CZ473569 CZ473570 CZ473780 CZ473811 CZ475133 CZ475134 CZ475251 CZ476737 CZ477080 CZ478037 CZ481737 CZ486504 CZ486505 CZ487327 CZ488075 CZ488076 G00758 U07606 U07607 U14401 Z97377 Entrez Gene - A searchable database of RefSeq genes. • 44548 UniProtKB/Swiss-Prot • P42283 P42284 Q7KQZ4 Q9V5M3 Q9V5M6 Q867Z4 UniProtKB/TrEMBL • Q7JPL9 Q8IGF5 Q9V5M3 Q9V5M6 Q95S45 Q95TA6 Q867Z4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • BTB/POZ-like (IPR000210) Zinc finger, C2H2 (IPR007087) BTB/POZ (IPR013069) BTB/POZ fold (IPR011333) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69126 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005630 DroID - A comprehensive database of gene and protein interactions. • FBgn0005630 DRSC - Results from RNAi screens. • FBgn0005630 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005630 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12052-RN;CG12052-RL;CG12052-RE;CG12052-RH;RH31485;CG12052-RF;CG12052-RS;CG12052-RQ;CG12052-RJ;CG12052-RI;CG12052-RM;CG12052-RK;CG12052-RG;CG12052-RC;CG12052-RP;CG12052-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005630 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44548 InParanoid A subset of ortholog calls from InParanoid. • AAEL009212-PC Aedes aegypti (mosquito) AGAP005245-PA Anopheles gambiae (mosquito) XP_001947442.1 Acyrthosiphon pisum (pea aphid) 124280 Branchiostoma floridae (lancelet) ENSBTAP00000015819 Bos taurus (bovine) ENSCAFP00000015939 Canis familiaris (dog) CPIJ015575 Culex pipens (mosquito) 327185 Daphnia pulex (daphnia) ENSGALP00000036650 Gallus gallus (chicken) ENSP00000377375 Homo sapiens (human) ENSMMUP00000039977 Macaca mulatta (rhesus monkey) ENSOANP00000007813 Ornithorynchus anatinus (platypus) PHUM005349-PA Pediculus humanus (human body louse) ENSPPYP00000015124 Pongo pygmaeus (orangutan) ENSPTRP00000057214 Pan troglodytes (chimpanzee) XP_976063.2 Tribolium castaneum (red flour beetle) ENSTNIP00000020015 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000004071 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000045910 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/lola.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44548 modMine - Data generated by the modENCODE project. • FBgn0005630 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0230794 FBgn0212687 FBgn0207272 FBgn0197247 FBgn0175393 FBgn0246413 FBgn0154795 FBgn0142917 FBgn0128084 FBgn0114898 CPIJ015576
Synonyms & Secondary IDs ( 33 )
Reported As
Symbol Synonym	BcDNA:LD17006   BcDNA:RH31485   BEST:LD03274   bs06a08.y1 (Oliver, 2001.8.16) BTB-IV (Laski, 1994.9.5, Zollman et al., 1994) BtbIV   CG12052 (Kleino et al., 2005, Norga et al., 2003, Ramet et al., 2002, Stempfl et al., 2002, Laviolette et al., 2005, Quinones-Coello, 2007, Perkins et al., 2009.3.31, Bossuyt et al., 2009, Keleman et al., 2009.8.5, Strub et al., 2008, Ni et al., 2011.7.19) CG18376   CG18378 (Ohsako et al., 2003, Brody et al., 2002, Stempfl et al., 2002, ) CG18379 (Ohsako et al., 2003, ) CG18380   CG18381 (Boutros et al., 2004, Ohsako et al., 2003, ) CG30012 (Ohsako et al., 2003, ) CG30013   CG30014   eyeful (Ferres-Marco et al., 2006, Ferres-Marco and Dominguez, 2001, ) fus7 (Weyers et al., 2011) l(2)00642 (Braun et al., 1997, ) l(2)s3697 (BDGP Project Members, 1994-1999, ) LD03274 (Toba et al., 1999) lola (Edwards et al., 2006, Bass and McCall, 2007, Laviolette et al., 2005, Gregory et al., 2007, Spletter et al., 2007, Nurminsky, 2007, Zhang et al., 2006, Buszczak et al., 2007, Quinones-Coello, 2007, Haynes et al., 2006, Zheng and Carthew, 2008, Maines et al., 2007, Blanco et al., 2010, Axelson, 2006, Mukai et al., 2007, Goeke et al., 2003, Gan et al., 2010, Christensen et al., 2008.9.3, Minidorff et al., 2007, Dorus et al., 2006, Dimitri et al., 2003, Spokony and Restifo, 2007, Yamamoto et al., 2008, Paige Bass et al., 2007, Ayroles et al., 2009, Krejcí et al., 2009, Bossuyt et al., 2009, McManus et al., 2010, Carreira et al., 2009, Tsubouchi et al., 2009, Shalaby et al., 2009, Spletter et al., 2007, Strub et al., 2008, Morozova et al., 2007, Wheeler et al., 2009, Magalhaes et al., 2007, Potter et al., 2010, Morozova et al., 2006, Buffin and Gho, 2010, Baig et al., 2010, Rouault et al., 2010, Otte et al., 2009, Foley et al., 2010, Klebes et al., 2002, Seong et al., 2011, Kim and Marqués, 2010, Weyers et al., 2011, Graveley et al., 2011, van Eyk et al., 2011, Neumüller et al., 2011, Cunha et al., 2010, Vallejo et al., 2011) Lola (Wagner et al., 2007, Wagner et al., 2007, Liefke et al., 2010) NEST:bs06a08   sw59
Name Synonym	BTB-protein-IV   e (Baig et al., 2010) eyeful (Liefke et al., 2010) lola (Herz et al., 2010) longitudinal lacking (Girard et al., 2006, Axelson, 2006) longitudinals absent (Baker et al., 2001) longitudinals lacking (Edwards et al., 2006, Robin et al., 2007, Davies et al., 2007, Goeke et al., 2003, Spokony and Restifo, 2007, Yamamoto et al., 2008, Carreira et al., 2009, Shalaby et al., 2009, Edwards et al., 2009, Spletter et al., 2007, Morozova et al., 2007, Buffin and Gho, 2010, Weyers et al., 2011) longitudinals-lacking (Paige Bass et al., 2007) Longitudinals lacking (Otte et al., 2009) misguided (Guillemin et al., 1997, ) SGP cluster fusion defects 7 (Weyers et al., 2011)
Secondary FlyBase IDs
	FBgn0010468 FBgn0010691 FBgn0012046 FBgn0020247 FBgn0026589 FBgn0033530 FBgn0033531 FBgn0033532 FBgn0033533 FBgn0033534 FBgn0033535 FBgn0045396 FBgn0045853 FBgn0050012 FBgn0050013 FBgn0050014 FBgn0063156 FBgn0064821
References ( 176 )
Generate a list of	All references relating to this gene ( 176 )
List References by type	Research paper  ( 99 ) Supplementary material  ( 18 ) Review  ( 8 ) Personal communication to FlyBase  ( 17 ) Abstract  ( 17 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 4 ) Conference report  ( 1 ) Protein sequence record  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Letter  ( 1 )
Recent research papers ( 16 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Vallejo et al., 2011, EMBO J. 30(4): 756--769 Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. [FBrf0213063] van Eyk et al., 2011, Hum. Mol. Genet. 20(14): 2783--2794 Perturbation of the Akt/Gsk3-{beta} signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. [FBrf0213942] Weyers et al., 2011, Dev. Biol. 353(2): 217--228 A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. [FBrf0213539] Baig et al., 2010, Genetics 184(3): 731--744 The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. [FBrf0210399] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Buffin and Gho, 2010, PLoS ONE 5(2): e9285 Laser microdissection of sensory organ precursor cells of Drosophila microchaetes. [FBrf0210039] Cunha et al., 2010, PLoS Genet. 6: e1001014 Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity. [FBrf0211225] Foley et al., 2010, Biol. Letts 6(1): 102--105 Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? [FBrf0209672] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Herz et al., 2010, Mol. Cell. Biol. 30(10): 2485--2497 The H3K27me3 demethylase dUTX is a suppressor of notch- and Rb-dependent tumors in Drosophila. [FBrf0210661] Kim and Marqués, 2010, Dev. Dyn. 239(9): 2413--2425 Identification of downstream targets of the Bone Morphogenetic Protein pathway in the Drosophila nervous system. [FBrf0211763] Liefke et al., 2010, Genes Dev. 24(6): 590--601 Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. [FBrf0210212] McManus et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(29): 12975--12979 Global analysis of trans-splicing in Drosophila. [FBrf0211338] Rouault et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14615--14620 Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny. [FBrf0211646] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...