probable transcriptional co-repressor - described as an AKAP binding protein, zinc finger protein expressed in the CNS and involved in axon guidance - required for proper morphogenesis of sensory neuron dendrites
Please see the JBrowse view of Dmel\nvy for information on other features
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Stop-codon suppression (UGA) postulated; FBrf0216885.
gene_with_stop_codon_read_through ; SO:0000697
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
3.243 (longest cDNA)
743 (aa); 76 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nvy using the Feature Mapper tool.
nvy is expressed in a complex and dynamic pattern. It is restricted to precursors of the central and peripheral nervous system. At certain stages, nvy is expressed in more cells or at higher levels in thoracic segments than in abdominal segments. These stages are separated by stages in which the expression pattern is the same in all segments. In later embryos, most of the nvy-expressing cells are in the posterior compartments of segments. nvy was shown to be induced by ubiquitous Ubx expression. nvy expression in various homeotic mutant backgrounds was also described.
GBrowse - Visual display of RNA-Seq signals
View Dmel\nvy in GBrowse 22-106
2-106
2-110.5
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: nvy CG3385
dsRNA has been made from templates generated with primers directed against this gene. RNAi of nvy results in increased arborization of ddaD and ddaE neurons. RNAi also causes defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
"60C" was stated as revision.