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Gene Dmel\nvy

General Information
Symbol	Dmel\nvy	Species	D. melanogaster
Name	nervy	Annotation symbol	CG3385
Feature type	protein_coding_gene	FlyBase ID	FBgn0005636
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60C5-60C6	Sequence location	2R:20,163,258..20,178,607 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene nervy is referred to in FlyBase by the symbol Dmel\nvy (CG3385, FBgn0005636). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: axon guidance; dendrite morphogenesis; chaeta morphogenesis; muscle organ development. 12 alleles are reported. The phenotypes of these alleles are annotated with: medial longitudinal fascicle; ventral nerve cord; lateral longitudinal fascicle; mechanosensory sensory organ; presumptive embryonic/larval central nervous system; abdominal segmental nerve; abdominal intersegmental nerve. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Eight-Twenty-One; NHR2-like; Nervy; TAFH/NHR1; Zinc finger, MYND-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1623977_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of nvy. Gene sequence location is 2R:20163258..20178607.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60C5-60C6   Limits computationally determined from genome sequence between P{lacW}Nop60Bk05318 and P{PZ}bs03267&P{lacW}l(2)k10502k10502
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60C-60C     (Feinstein et al., 1999) 99F-99F     (Mann, 1995.2.24) 60C-60C   Map location of 99F reported in FBrf0081987 was an error. (determined by in situ hybridisation)   (Mann, 1999.8.31)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\nvy for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Stop-codon suppression (UGA) postulated; FBrf0216885. gene_with_stop_codon_read_through ; SO:0000697 Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) nvy-RA FBtr0072267  NM_079117   3425   743 nvy-RB FBtr0330610  NM_001274235   3097   742 nvy-RC FBtr0330611  NM_001274236   3104   742 nvy-RD FBtr0330612  NM_001274237   3425   757
Additional Transcript Data & Comments
Reported size (kB)	3.243 (longest cDNA) (Feinstein et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein nvy-PA   FBpp0072174   76.5   743   8.37     NP_523841   AAF47191 nvy-PB   FBpp0303460   76.4   742   8.37     NP_001261164   AGB93694 nvy-PC   FBpp0303461   76.4   742   8.37     NP_001261165   AGB93695 nvy-PD   FBpp0303462   78.2   757   9.01     NP_001261166   AGB93696
Additional Polypeptide Data & Comments
Reported size (kDa)	743 (aa); 76 (kD) (Feinstein et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, MYND-type (IPR002893) TAFH/NHR1 (IPR003894) Eight-Twenty-One (IPR013289) Nervy (IPR013293) NHR2-like (IPR014896)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539398   AE013599 AAF47191   AE013599 AGB93694   AE013599 AGB93695   AE013599 AGB93696   AW942449   BI369312   BI565042   BI565558   BI573482   BI573483   BI574082   BI574083   BI608592   BI608630   BI622553   BI624483   BI634983   BT004898 AAO47876   BT125650   BT133200   CO189892   CO190902   CO263667   CO270118   CO270398   CO290662   CO309377   CO320232   EC059743   EC070810   EC080815   EC090020   EC195601   EC196977   EC201923   EC208013   EC219656   GH749124   GH753922   GH756120   GH756237   GH759836   GH771837   GH780897   GH782154   GH782283   GH783444   GH785056   GH787156   GH790168   GH791116   GH793021   GH800716   GH807203   GH810399   GH815002   GH823151   GH826115   GH828808   GH829546   GH833978   GH839669   GH840629   GH842893   GH843203   GH845670   GH846819   GH846875   GH855444   GH855884   GH866368   GH868733   GH869492   GH872200   GH878173   GH880995   GH882733   GH883945   GH884892   GH886536   GH887508   GH888330   GH889794   GH894438   GH905780   GH906751   GH910048   GH912767   GH914200   GH917702   GH919840   GH921558   GH921784   GH927312   GH929870   GH930073   GH930403   GH936945   GH938173   GH938578   GH938721   GH939114   GH939681   GH939704   GH939944   GH940140   GH940393   GH940633   GH940708   GH941043   U21717 AAA92045
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W186 Q24037
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435258 2R:20,163,828..20,164,827 evidence=Reporter construct (in vivo) (Rouault et al., 2010, Halfon, 2012.6.19) regulatory region FBsf0000435650 2R:20,162,435..20,163,434 evidence=Reporter construct (in vivo) (Rouault et al., 2010, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   organism | subset   (Fisher et al., 2012) embryonic stage 7 -- 8   ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 9 -- 17   neuroblast   (Feinstein et al., 1995) presumptive embryonic/larval peripheral nervous system | restricted   (Feinstein et al., 1995) central nervous system | restricted   (Feinstein et al., 1995) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) ventral sensory complex anlage   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) ventral sensory complex primordium   (Fisher et al., 2012)
Additional Descriptive Data
	nvy is expressed in a complex and dynamic pattern. It is restricted to precursors of the central and peripheral nervous system. At certain stages, nvy is expressed in more cells or at higher levels in thoracic segments than in abdominal segments. These stages are separated by stages in which the expression pattern is the same in all segments. In later embryos, most of the nvy-expressing cells are in the posterior compartments of segments. nvy was shown to be induced by ubiquitous Ubx expression. nvy expression in various homeotic mutant backgrounds was also described. (Feinstein et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Wildonger and Mann, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland    702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland    922.3 Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland  (702.2) Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland  (922.3) Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland    702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland    922.3 Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland    702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland    922.3 Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland    702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland    922.3 Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland  702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland  (922.3) Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland    702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland    922.3 Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    403.85 Larval Midgut    10.3 Larval Hindgut    29.4 Larval Malpighian Tubules    30.5 Larval Fat Body    16.3 Larval Salivary Gland    702.2 Larval Trachea    5.7 Larval Carcass    27.875 Adult Head    84.8 Adult Eye    9.6 Adult Brain    339.8 Adult Thoracic-Abdominal Ganglion    290 Adult Crop    14.1 Adult Midgut    19.4 Adult Hindgut    9.2 Adult Malpighian Tubules    63 Adult Fat Body    9.4 Adult Salivary Gland    922.3 Adult Heart    17.225 Adult VirginFemale Spermatheca    10.6 Adult InseminatedFemale Spermatheca    6.7 Adult Ovary    0.7 Adult Testis    44.6 Adult Male Accessory Gland    9.3 Adult Carcass    13.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    84.8   NA  Eye    9.6   NA  Brain    339.8   403.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    290   NA  Crop    14.1   10.3  Midgut    19.4   29.4  Hindgut    9.2   30.5  Malpighian Tubules    63   16.3  Fat Body    9.4   702.2  Salivary Gland    922.3   NA  Heart    17.225   5.7  Trachea    NA   NA  VirginFemale Spermatheca    10.6   NA  InseminatedFemale Spermatheca    6.7   NA  Ovary    0.7   NA  Testis    44.6   NA  Male Accessory Gland    9.3   27.875  Carcass    13.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    9 central nervous system, pupae P8    10 head, virgin 1-day female    3 head, virgin 4-day female    2 head, virgin 20-day female    1 head, mated 1-day female    3 head, mated 4-day female    2 head, mated 20-day female    1 head, mated 1-day male    4 head, mated 4-day male    4 head, mated 20-day male    3 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    1 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    9 embryo 06-08hr    17 embryo 08-10hr    12 embryo 10-12hr    15 embryo 12-14hr    10 embryo 14-16hr    15 embryo 16-18hr    13 embryo 18-20hr    15 embryo 20-22hr    9 embryo 22-24hr    8 larva L1    7 larva L2    2 larva L3 12hr old    2 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    4 larva L3 puffstage 7-9    4 white prepupae new    4 white prepupae 12hr    8 white prepupae 24hr    8 pupae 2d postWPP    6 pupae 3d postWPP    5 pupae 4d postWPP    5 adult male 01day    5 adult male 05day    6 adult male 30day    6 adult female 01day    2 adult female 05day    1 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    67 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    81 leg disc CME L1    40 wing disc CME-W2    2 wing disc ML-DmD8    37 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4  (67) embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3  (81) leg disc CME L1  (40) wing disc CME-W2    2 wing disc ML-DmD8  (37) wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    67 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    81 leg disc CME L1    40 wing disc CME-W2    2 wing disc ML-DmD8    37 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    67 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    81 leg disc CME L1    40 wing disc CME-W2    2 wing disc ML-DmD8    37 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    67 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    81 leg disc CME L1    40 wing disc CME-W2    2 wing disc ML-DmD8    37 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4  (67) embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3  (81) leg disc CME L1  (40) wing disc CME-W2    2 wing disc ML-DmD8  (37) wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    67 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    81 leg disc CME L1    40 wing disc CME-W2    2 wing disc ML-DmD8    37 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2 Schneider line 2 Sg4    67 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    81 leg disc CME L1    40 wing disc CME-W2    2 wing disc ML-DmD8    37 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    2 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    3 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    1 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    3 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • LD17501 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005636 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3385-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for nvy Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4neur-GAL4-A101 nvyScer\UAS.T:Hsim\VP16 viable, with Scer\GAL4pnr-MD237 nvyGD2202 Other Phenotypes Allele neuroanatomy defective nvyPDFKG1 nvyPDFKG38 neuroanatomy defective, with Scer\GAL4elav-C155 nvyScer\UAS.cTa nvyV523P.Scer\UAS.T:Hsap\MYC Phenotype manifest in Allele abdominal dorsal multidendritic neuron ddaE & dendrite nvyPDFKG1 abdominal intersegmental nerve nvyPDFKG1 nvyPDFKG38 abdominal intersegmental nerve, with Scer\GAL4elav-C155 nvyScer\UAS.cTa nvyV523P.Scer\UAS.T:Hsap\MYC abdominal segmental nerve nvyPDFKG1 nvyPDFKG38 abdominal segmental nerve, with Scer\GAL4elav-C155 nvyScer\UAS.cTa nvyV523P.Scer\UAS.T:Hsap\MYC adult thorax & mechanosensory sensory organ, with Scer\GAL4sca-537.4 nvyScer\UAS.cWa adult thorax & mechanosensory sensory organ | somatic clone, with Scer\GAL4αTub84B.PZ nvyScer\UAS.cWa adult thorax | dorsal & mechanosensory sensory organ, with Scer\GAL4pnr-MD237 nvyScer\UAS.cWa cuticle | somatic clone, with Scer\GAL4pnr-MD237 nvyScer\UAS.T:Hsim\VP16 dorsal multidendritic neuron ddaE & dendrite nvyPDFKG1 lateral longitudinal fascicle nvyPDFKG1 nvyPDFKG38 lateral longitudinal fascicle, with Scer\GAL4elav-C155 nvyScer\UAS.cTa nvyV523P.Scer\UAS.T:Hsap\MYC mechanosensory neuron | somatic clone, with Scer\GAL4neur-GAL4-A101 nvyScer\UAS.T:Hsim\VP16 mechanosensory neuron | somatic clone, with Scer\GAL4pnr-MD237 nvyScer\UAS.T:Hsim\VP16 mechanosensory sensory organ, with Scer\GAL4sca-C253 nvyScer\UAS.T:Hsim\VP16 mechanosensory sensory organ & thorax, with Scer\GAL4pnr-MD237 nvyδZF.Scer\UAS mechanosensory sensory organ | somatic clone, with Scer\GAL4neur-GAL4-A101 nvyScer\UAS.T:Hsim\VP16 mechanosensory sensory organ | somatic clone, with Scer\GAL4pnr-MD237 nvyScer\UAS.T:Hsim\VP16 medial longitudinal fascicle, with Scer\GAL4elav-C155 nvyScer\UAS.cTa presumptive embryonic/larval central nervous system nvyPDFKG1 nvyPDFKG38 presumptive embryonic/larval central nervous system, with Scer\GAL4elav-C155 nvyScer\UAS.cTa nvyV523P.Scer\UAS.T:Hsap\MYC sensory mother cell | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PZ nvyScer\UAS.cWa sensory mother cell | somatic clone nvyPDFKG1 sensory mother cell | somatic clone, with Scer\GAL4αTub84B.PZ nvydsRNA.Scer\UAS thecogen cell | somatic clone, with Scer\GAL4neur-GAL4-A101 nvyScer\UAS.T:Hsim\VP16 ventral nerve cord nvyPDFKG1 nvyPDFKG38 ventral nerve cord, with Scer\GAL4elav-C155 nvyScer\UAS.cTa nvyV523P.Scer\UAS.T:Hsap\MYC
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of nvy Class Mutagen Stocks Known lesion nvyf04145 1 -- nvyPDFKG1 loss of function allele 0 -- nvyPDFKG38 loss of function allele 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of nvy Class Mutagen Stocks Known lesion nvyGD2202 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes nvyJF03349 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nvyKK107374 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nvydsRNA.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes nvyScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes nvyScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes nvyScer\UAS.T:Hsim\VP16 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes nvyV523P.Scer\UAS.T:Hsap\MYC antimorphic allele - genetic evidence in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes nvyδZF.Scer\UAS in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6081 (Ryder, 2004.4.26) Df(2R)Exel6082 (Ryder, 2004.4.26) Df(2R)Exel6281 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2202} NA P{KK107374} NA P{TRiP.JF03349} NA P{UAS-nvy.dsRNA} NA P{UAS-nvy.T} NA P{UAS-nvy.V523P} NA P{UAS-nvy.W} NA P{UAS-nvy.δZF} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}nvyf04145 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Terman and Kolodkin, 2004) chaeta morphogenesis inferred from mutant phenotype (Wildonger and Mann, 2005) dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) muscle organ development inferred from mutant phenotype (Parrish et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Wildonger and Mann, 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with InterPro:IPR003894 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR002893 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with InterPro:IPR003894 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with InterPro:IPR003894 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis, 2011.11.18) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
nvy - CG4730 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions nvy allele Gene References nvyPDFKG38 Sema-1a (Terman and Kolodkin, 2004) unspecified ase (Wildonger and Mann, 2005) da (Wildonger and Mann, 2005) Dl (Wildonger and Mann, 2005) N (Wildonger and Mann, 2005) sc (Wildonger and Mann, 2005) sens (Wildonger and Mann, 2005)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005636 DroID - A comprehensive database of gene and protein interactions. • FBgn0005636 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37886
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11849 Drosophila sechellia Dsec\GM11850 Drosophila erecta Dere\GG22957 Drosophila yakuba Dyak\GE14394 Drosophila ananassae Dana\GF11389 Drosophila pseudoobscura pseudoobscura Dpse\GA24088 Drosophila persimilis Dper\GL20013 Drosophila willistoni Dwil\GK22201 Drosophila virilis Dvir\GJ21589 Drosophila mojavensis Dmoj\GI21319 Drosophila grimshawi Dgri\GH20984
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	29413 y1 v1; P{TRiP.JF03349}attP2
Harvard	- PBac{WH}nvyf04145
VDRC	v100273 P{KK107374}VIE-260B v24502 w1118; P{GD2202}v24502 v3618 w1118; P{GD2202}v3618/TM3
Genomic Clones ( 1 )
	BACR04P18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 103 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12877 LD17501
Other clones	DPiM_LD17501 FI19422
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE55452 RH13155 RH13211 RH39971 RH54446 RH62692 RH63346 RH64048
Other clones	83632 178312 CK01.56B.G1 CK01.62B.A4 CK01.99B.F5 CK01.106D.C3 CK01.109A.E12 CK01.127B.H1 EK045525 EK050026 EK074701 EK089211 EK097422 EK098750 EK217449 EK282956 RH09110 RH09482 RP003035798 RP003056533 RP003065458 RP003074050 RP003086376 RP003091799 RP003102174 RP003118022 RP003160177 RP003161488 RP003183174 RP003201482 RP003214955 RP003219525 RP003240159 RP003248590 RP003254093 RP003255609 RP003264264 RP003266097 RP003288505 RP003296445 RP003298951 RP003303049 RP003316961 RP003317545 RP003318938 RP003323120 RP003327018 RP003329293 RP003336413 RP003340317 RP003377393 RP003392681 RP003412707 RP003416879 RP003424713 RP003435444 RP003450438 RP003451429 RP003457050 RP003457426 RP003483980 RP003485718 RP003492554 RP003496952 RP003517236 RP003525420 RP003526211 RP003533785 RP003540109 RP003556312 RP003564309 RP003565062 RP003566348 RP003571382 RP003577733 RP003582827 RP003594926 RP003601142 RP003604297 RP003613259 RP003620135 RP003624610 RP003626388 RP003632333 RP003634572 RP003636166 RP003639801 RP003643628 RP003652729 RP003673870 RP003675058
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005636 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37886
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: nvy CG3385 (Wang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. RNAi of nvy results in increased arborization of ddaD and ddaE neurons. RNAi also causes defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) nvy couples cAMP-PKA signaling to plexA to regulate Sema-1a-mediated axon repulsion. nvy and Sema-1a function in the same signaling pathway but have opposing effects. nvy acts downstream of Sema-1a to regulate repulsive axon guidance. (Terman and Kolodkin, 2004) "60C" was stated as revision. (Feinstein et al., 1999) The expression of nvy in a subset of delaminating neuroblasts during the early stages of neurogenesis suggest a role for nvy in neuroblast determination. (Abu-Shaar et al., 1995) Isolated during a subtractive hybridisation protocol to identify Ubx-activated target genes. Ubx inducible during embryogenesis. (Feinstein et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079117 NM_001274235 NM_001274236 NM_001274237 RefSeq (Proteins) • NP_523841 NP_001261164 NP_001261165 NP_001261166 DDBJ / EMBL / GenBank • AA539398 AAA92045 AAF47191 AAO47876 AGB93694 AGB93695 AGB93696 AW942449 BT004898 U21717 Entrez Gene - A searchable database of RefSeq genes. • 37886 UniProtKB/TrEMBL • Q9W186 Q24037
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, MYND-type (IPR002893) TAFH/NHR1 (IPR003894) Eight-Twenty-One (IPR013289) Nervy (IPR013293) NHR2-like (IPR014896) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD17501
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005636 DroID - A comprehensive database of gene and protein interactions. • FBgn0005636 DRSC - Results from RNAi screens. • FBgn0005636 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005636 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3385-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005636 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37886 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/nervy1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37886 modMine - Data generated by the modENCODE project. • FBgn0005636
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG3385 (Keleman et al., 2009.8.5, Perkins et al., 2009, Aerts et al., 2010) nervy (Brody et al., 2008) nvy (Hazelett et al., 2012, Foglietti et al., 2006, Cafferty et al., 2006, Ming et al., 2008, Southall and Brand, 2009, Jungreis, 2011.11.18, Buffin and Gho, 2010, Wang et al., 2004, Schirling et al., 2010, Aerts et al., 2010) Nvy (Parrish et al., 2006)
Name Synonym	nervy (Jafar-Nejad and Bellen, 2004, Botas and Auwers, 1996, Rossetti et al., 2004, Ming et al., 2008, Buffin and Gho, 2010, Kuzin et al., 2011, Duvall and Taghert, 2012) Nervy (Yang and Terman, 2012, Ice et al., 2005)
Secondary FlyBase IDs
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 3 ) Review  ( 5 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Duvall and Taghert, 2012, PLoS Biol. 10(6): e1001337 The Circadian Neuropeptide PDF Signals Preferentially through a Specific Adenylate Cyclase Isoform AC3 in M Pacemakers of Drosophila. [FBrf0218594] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Yang and Terman, 2012, Neuron 74(1): 108--121 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion. [FBrf0218615] Kuzin et al., 2011, Mech. Dev. 128(3-4): 165--177 Functional analysis of conserved sequences within a temporally restricted neural precursor cell enhancer. [FBrf0213297] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...