FB2020_06, released Dec 22, 2020

Gene: Dmel\nvy

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General Information
Symbol
Dmel\nvy
Species
D. melanogaster
Name
nervy
Annotation Symbol
CG3385
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005636
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Snapshot
nervy (nvy) is a member of the MTG family of genes that have both nuclear and cytosolic functions. nvy encodes a transcriptional repressor and an A kinase anchoring protein (AKAP). It regulates repulsive axon guidance and functions in Plexin and Notch signaling pathways. [Date last reviewed: 2018-09-20]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
60C5-60C6
Sequence location
2R:24,275,734..24,291,084 [+]
Recombination map

2-106

RefSeq locus
NT_033778 REGION:24275734..24291084
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR003894
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables transcription corepressor activity
inferred from biological aspect of ancestor with PANTHER:PTN000822368
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from mutant phenotype
(Terman and Kolodkin, 2004)
involved_in chaeta morphogenesis
inferred from mutant phenotype
(Wildonger and Mann, 2005)
involved_in circadian rhythm
inferred from mutant phenotype
(assigned by UniProt )
(Duvall and Taghert, 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of transcription, DNA-templated
inferred from biological aspect of ancestor with PANTHER:PTN000822368
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Wildonger and Mann, 2005)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000822368
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Summary (Interactive Fly)

probable transcriptional co-repressor - described as an AKAP binding protein, zinc finger protein expressed in the CNS and involved in axon guidance - required for proper morphogenesis of sensory neuron dendrites

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\nvy for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216885.

gene_with_stop_codon_read_through ; SO:0000697

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis, 2011.11.18)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
nvy-RA
FBtr0072267
NM_079117
3426
743
nvy-RB
FBtr0330610
NM_001274235
3097
742
nvy-RC
FBtr0330611
NM_001274236
3104
742
nvy-RD
FBtr0330612
NM_001274237
3426
757
Additional Transcript Data and Comments
Reported size (kB)

3.243 (longest cDNA)

(Feinstein et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
nvy-PA
FBpp0072174
76.5
743
8.37
NP_523841
AAF47191
nvy-PB
FBpp0303460
76.4
742
8.37
NP_001261164
AGB93694
nvy-PC
FBpp0303461
76.4
742
8.37
NP_001261165
AGB93695
nvy-PD
FBpp0303462
78.2
757
9.01
NP_001261166
AGB93696
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

742 aa isoforms: nvy-PB, nvy-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

743 (aa); 76 (kD)

(Feinstein et al., 1995)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nvy using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 9 -- 17
neuroblast
(Feinstein et al., 1995)
presumptive embryonic/larval peripheral nervous system | restricted
(Feinstein et al., 1995)
central nervous system | restricted
(Feinstein et al., 1995)
embryonic stage 4 -- 6
organism | subset
(Fisher et al., 2012)
embryonic stage 7 -- 8
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
dorsal ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic neuroblast of ventral nerve cord primordium
(Fisher et al., 2012)
midline ventral glial cell
(Fisher et al., 2012)
procephalic neuroblast
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
ventral sensory complex anlage
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain
(Fisher et al., 2012)
embryonic central brain glial cell
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
sensory nervous system primordium
(Fisher et al., 2012)
ventral midline of embryo
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
larval midline neuron
(Kearney et al., 2004)
embryonic stage 9 -- 12
midline primordium | subset
(Kearney et al., 2004)
Additional Descriptive Data

nvy is expressed in a complex and dynamic pattern. It is restricted to precursors of the central and peripheral nervous system. At certain stages, nvy is expressed in more cells or at higher levels in thoracic segments than in abdominal segments. These stages are separated by stages in which the expression pattern is the same in all segments. In later embryos, most of the nvy-expressing cells are in the posterior compartments of segments. nvy was shown to be induced by ubiquitous Ubx expression. nvy expression in various homeotic mutant backgrounds was also described.

(Feinstein et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
embryonic/larval central nervous system | subset
(Ice et al., 2005)
embryonic/larval peripheral nervous system | subset
(Ice et al., 2005)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in nucleus
inferred from direct assay
(Wildonger and Mann, 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\nvy in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of nvy
Transgenic constructs containing regulatory region of nvy
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4neur-GAL4-A101
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4elav-C155
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaE & dendrite
abdominal intersegmental nerve
abdominal intersegmental nerve, with Scer\GAL4elav-C155
abdominal segmental nerve
abdominal segmental nerve, with Scer\GAL4elav-C155
adult thorax & mechanosensory sensory organ, with Scer\GAL4sca-537.4
adult thorax & mechanosensory sensory organ | somatic clone, with Scer\GAL4αTub84B.PZ
adult thorax | dorsal & mechanosensory sensory organ, with Scer\GAL4pnr-MD237
cuticle | somatic clone, with Scer\GAL4pnr-MD237
dorsal multidendritic neuron ddaE & dendrite
lateral longitudinal fascicle
lateral longitudinal fascicle, with Scer\GAL4elav-C155
mechanosensory neuron | somatic clone, with Scer\GAL4neur-GAL4-A101
mechanosensory neuron | somatic clone, with Scer\GAL4pnr-MD237
mechanosensory sensory organ, with Scer\GAL4sca-C253
mechanosensory sensory organ & thorax, with Scer\GAL4pnr-MD237
mechanosensory sensory organ | somatic clone, with Scer\GAL4neur-GAL4-A101
mechanosensory sensory organ | somatic clone, with Scer\GAL4pnr-MD237
medial longitudinal fascicle, with Scer\GAL4elav-C155
presumptive embryonic/larval central nervous system
presumptive embryonic/larval central nervous system, with Scer\GAL4elav-C155
sensory mother cell | cell non-autonomous | somatic clone, with Scer\GAL4αTub84B.PZ
sensory mother cell | somatic clone
sensory mother cell | somatic clone, with Scer\GAL4αTub84B.PZ
thecogen cell | somatic clone, with Scer\GAL4neur-GAL4-A101
ventral nerve cord
ventral nerve cord, with Scer\GAL4elav-C155
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CBFA2T3
13 of 15
Yes
Yes
Hsap\CBFA2T2
11 of 15
No
Yes
Hsap\RUNX1T1
11 of 15
No
Yes
2  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cbfa2t3
14 of 15
Yes
Yes
Mmus\Cbfa2t2
11 of 15
No
Yes
Mmus\Runx1t1
11 of 15
No
Yes
Rattus norvegicus (Norway rat) (3)
Rnor\Cbfa2t3
12 of 13
Yes
Yes
Rnor\Cbfa2t2
11 of 13
No
Yes
Rnor\Runx1t1
8 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (3)
Xtro\cbfa2t3
9 of 12
Yes
Yes
Xtro\cbfa2t2
8 of 12
No
Yes
Xtro\runx1t1
8 of 12
No
Yes
Danio rerio (Zebrafish) (3)
Drer\cbfa2t3
13 of 15
Yes
Yes
Drer\runx1t1
8 of 15
No
Yes
Drer\cbfa2t2
4 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908P4 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002261
Drosophila simulans
Dsim\GD11849
Drosophila sechellia
Dsec\GM11850
Drosophila erecta
Dere\GG22957
Drosophila yakuba
Dyak\GE14394
Drosophila ananassae
Dana\GF11389
Drosophila pseudoobscura pseudoobscura
Dpse\GA24088
Drosophila persimilis
Dper\GL20013
Drosophila willistoni
Dwil\GK22201
Drosophila virilis
Dvir\GJ21589
Drosophila mojavensis
Dmoj\GI21319
Drosophila grimshawi
Dgri\GH20984
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504IJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025686
Musca domestica
House fly
Mdoa\17010659
Glossina morsitans
Tsetse fly
Gmor\GMOY009389
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04340
Mayetiola destructor
Hessian fly
Mdes\Mdes007504
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003615
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014203
Anopheles darlingi
American malaria mosquito
Adar\ADAC005218
Anopheles gambiae
Malaria mosquito
Agam\AGAP010867
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0NGD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009158
Danaus plexippus
Monarch butterfly
Dple\DPOGS213352-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016380
Apis florea
Little honeybee
Aflo\2296586116
Apis mellifera
Western honey bee
Amel\GB44078
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21362
Bombus terrestris
Buff-tailed bumblebee
Bter\15215802
Linepithema humile
Argentine ant
Lhum\LH14603
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002187
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003201
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06026
Tribolium castaneum
Red flour beetle
Tcas\TC033825
Pediculus humanus
Human body louse
Phum\PHUM399560
Rhodnius prolixus
Kissing bug
Rpro\RPRC013425
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI35910
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03458
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03459
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0FC2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009892
Ixodes scapularis
Black-legged tick
Isca\ISCW013533
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64081.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM60079.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g01570
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_8906
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CBFA2T3; CBFA2/RUNX1 partner transcriptional co-repressor 3
    13 of 15
    603870
        CBFA2T2; CBFA2/RUNX1 partner transcriptional co-repressor 2
        11 of 15
        603672
            RUNX1T1; RUNX1 partner transcriptional co-repressor 1
            11 of 15
            133435
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                esyN Network Diagram
                Show neighbor-neighbor interactions:
                Select Layout:
                Legend:
                Protein
                RNA
                Selected Interactor(s)
                Interactions Browser
                View in Interactions Browser
                Please see the Physical Interaction reports below for full details
                protein-protein
                Physical Interaction
                Assay
                References
                nvy - da
                pull down, western blot
                (Wildonger and Mann, 2005)
                nvy - hrg
                anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                (Rhee et al., 2014)
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                nvy
                suppressible
                ase
                (Wildonger and Mann, 2005)
                nvy
                suppressible
                da
                (Wildonger and Mann, 2005)
                nvy
                suppressible
                sens
                (Wildonger and Mann, 2005)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                ase
                suppressible
                nvy
                (Wildonger and Mann, 2005)
                da
                enhanceable
                nvy
                (Wildonger and Mann, 2005)
                da
                suppressible
                nvy
                (Wildonger and Mann, 2005)
                Dl
                enhanceable
                nvy
                (Wildonger and Mann, 2005)
                N
                enhanceable
                nvy
                (Wildonger and Mann, 2005)
                sc
                suppressible
                nvy
                (Wildonger and Mann, 2005)
                Sema1a
                enhanceable
                nvy
                (Terman and Kolodkin, 2004)
                External Data
                Linkouts
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                2R
                Recombination map

                2-106

                Cytogenetic map
                60C5-60C6
                Sequence location
                2R:24,275,734..24,291,084 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                60C5-60C6
                Limits computationally determined from genome sequence between P{lacW}Nop60Bk05318 and P{PZ}bs03267&P{lacW}l(2)k10502k10502
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                60C-60C
                (Feinstein et al., 1999)
                99F-99F
                (Mann, 1995.2.24)
                60C-60C
                (determined by in situ hybridisation)
                (Mann, 1999.8.31)
                Map location of 99F reported in FBrf0081987 was an error.
                (Mann, 1999.8.31)
                Experimentally Determined Recombination Data
                Location

                2-106

                (FlyBase, 2016)

                2-110.5

                (Comeron et al., 2012)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (8)
                Genomic Clones (23)
                cDNA Clones (99)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Source for database identify of

                Source for identity of: nvy CG3385

                (Wang, 1999.11)
                Source for database merge of
                Additional comments
                Other Comments

                dsRNA has been made from templates generated with primers directed against this gene. RNAi of nvy results in increased arborization of ddaD and ddaE neurons. RNAi also causes defects in muscle, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

                (Parrish et al., 2006)

                nvy couples cAMP-PKA signaling to plexA to regulate Sema-1a-mediated axon repulsion. nvy and Sema-1a function in the same signaling pathway but have opposing effects. nvy acts downstream of Sema-1a to regulate repulsive axon guidance.

                (Terman and Kolodkin, 2004)

                "60C" was stated as revision.

                (Feinstein et al., 1999)

                The expression of nvy in a subset of delaminating neuroblasts during the early stages of neurogenesis suggest a role for nvy in neuroblast determination.

                (Abu-Shaar et al., 1995)

                Isolated during a subtractive hybridisation protocol to identify Ubx-activated target genes. Ubx inducible during embryogenesis.

                (Feinstein et al., 1995)
                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 49 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                modMine - A data warehouse for the modENCODE project
                Linkouts
                DPiM - Drosophila Protein interaction map
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                FlyMine - An integrated database for Drosophila genomics
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Synonyms and Secondary IDs (5)
                Datasets (0)
                Study focus (0)
                Experimental Role
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                References (78)