FB2020_01, released Feb 12, 2020

Gene: Dmel\Eip63E

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General Information
Symbol
Dmel\Eip63E
Species
D. melanogaster
Name
Ecdysone-induced protein 63E
Annotation Symbol
CG10579
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005640
Gene Model Status
Current
Stock Availability
21 publicly available
Enzyme Name (EC)
Cyclin-dependent kinase (2.7.11.22)
Gene Snapshot
Ecdysone-induced protein 63E (Eip63E) encodes a cyclin-dependent kinase that interacts with the product of CycY. It contributes to embryogenesis, larval development and metamorphosis. [Date last reviewed: 2019-08-01]
Other Summaries
Also Known As

L63, PFTAIRE, cdc2-63E

Key Links
Genomic Location
Cytogenetic map
63E3-63E5
Sequence location
3L:3,515,751..3,610,521 [+]
Recombination map

3-8

RefSeq locus
NT_037436 REGION:3515751..3610521
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
cyclin binding; cyclin-dependent protein serine/threonine kinase activity; protein binding; protein kinase activity
Predictions / Assertions
ATP binding; cyclin binding; cyclin-dependent protein serine/threonine kinase activity; heme binding; protein serine/threonine kinase activity
Catalytic Activity (EC)
Experimental Evidence
ATP + a protein = ADP + a phosphoprotein (2.7.11.22)
Predictions / Assertions
ATP + a protein = ADP + a phosphoprotein (2.7.11.22)
Summaries
Gene Group (FlyBase)
CYCLIN DEPENDENT KINASES -
Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose activity depends on a regulatory cyclin subunit. (Adapted from PMID:25180339).
Summary (Interactive Fly)

cyclin dependent kinase that plays a role in cell differentiation rather than in cell division

Gene Model and Products
Number of Transcripts
14
Number of Unique Polypeptides
6

Please see the GBrowse view of Dmel\Eip63E or the JBrowse view of Dmel\Eip63E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Eip63E-RA
FBtr0073133
NM_168034
2700
509
Eip63E-RB
FBtr0073134
NM_168035
2919
509
Eip63E-RC
FBtr0073135
NM_168036
2891
509
Eip63E-RD
FBtr0073131
NM_079180
3575
522
Eip63E-RE
FBtr0073132
NM_168033
2981
522
Eip63E-RF
FBtr0110920
NM_001043116
3536
509
Eip63E-RG
FBtr0110921
NM_001043120
2958
522
Eip63E-RH
FBtr0110922
NM_001043117
2625
501
Eip63E-RI
FBtr0110923
NM_001043119
2739
522
Eip63E-RJ
FBtr0110924
NM_001043121
4769
509
Eip63E-RK
FBtr0110925
NM_001043118
2930
522
Eip63E-RL
FBtr0301948
NM_001169869
3311
522
Eip63E-RM
FBtr0302598
NM_001202113
4914
509
Eip63E-RN
FBtr0330068
NM_001274444
3575
538
Additional Transcript Data and Comments
Reported size (kB)

3.4 (northern blot)

(Sauer et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Eip63E-PA
FBpp0072992
58.5
509
8.88
NP_728889
AAG22238
Eip63E-PB
FBpp0072993
58.5
509
8.88
NP_728890
AAF47781
Eip63E-PC
FBpp0072994
58.5
509
8.88
NP_728891
AAG22239
Eip63E-PD
FBpp0072990
59.8
522
8.87
NP_523904
AAN11568
Eip63E-PE
FBpp0072991
59.8
522
8.87
NP_728888
AAN11569
Eip63E-PF
FBpp0110220
58.3
509
8.88
NP_001036581
ABI31232
Eip63E-PG
FBpp0110221
59.9
522
8.87
NP_001036585
ABI31236
Eip63E-PH
FBpp0110222
57.7
501
8.88
NP_001036582
ABI31233
Eip63E-PI
FBpp0110223
59.9
522
8.87
NP_001036584
ABI31235
Eip63E-PJ
FBpp0110224
58.5
509
8.88
NP_001036586
ABI31237
Eip63E-PK
FBpp0110225
59.9
522
8.87
NP_001036583
ABI31234
Eip63E-PL
FBpp0291160
59.9
522
8.87
NP_001163340
ACZ94612
Eip63E-PM
FBpp0291754
58.3
509
8.88
NP_001189042
ADV37479
Eip63E-PN
FBpp0303101
61.6
538
9.03
NP_001261373
AGB94068
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

509 aa isoforms: Eip63E-PF, Eip63E-PM
522 aa isoforms: Eip63E-PG, Eip63E-PI, Eip63E-PK, Eip63E-PL
509 aa isoforms: Eip63E-PA, Eip63E-PB, Eip63E-PC, Eip63E-PJ
522 aa isoforms: Eip63E-PD, Eip63E-PE
Additional Polypeptide Data and Comments
Reported size (kDa)

509 (aa)

(Sauer et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip63E using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
cyclin binding
inferred from mutant phenotype
(Stowers et al., 2000)
cyclin-dependent protein serine/threonine kinase activity
inferred from mutant phenotype
(Stowers et al., 2000)
protein binding
inferred from physical interaction with FLYBASE:Pif2; FB:FBgn0046873
(Rascle et al., 2003)
inferred from physical interaction with FLYBASE:Pif1B; FB:FBgn0046874
(Rascle et al., 2003)
protein kinase activity
inferred from direct assay
(Rascle et al., 2003)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
cyclin binding
inferred from biological aspect of ancestor with PANTHER:PTN001172735
(assigned by GO_Central )
(Gaudet et al., 2011)
cyclin-dependent protein serine/threonine kinase activity
inferred from sequence or structural similarity with SGD:S000000364
(Stowers et al., 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(assigned by GO_Central )
(Gaudet et al., 2011)
heme binding
inferred from electronic annotation with InterPro:IPR018506
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein serine/threonine kinase activity
inferred from sequence or structural similarity with UniProtKB:Q00536
(Sauer et al., 1996)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
developmental growth
inferred from mutant phenotype
(Liu and Finley, 2010)
embryonic development via the syncytial blastoderm
inferred from mutant phenotype
(Stowers et al., 2000)
instar larval development
inferred from mutant phenotype
(Stowers et al., 2000)
metamorphosis
inferred from mutant phenotype
(Stowers et al., 2000)
morphogenesis of an epithelium
inferred from mutant phenotype
(Stowers et al., 2000)
protein phosphorylation
inferred from mutant phenotype
(Sopko et al., 2014)
inferred from direct assay
(Rascle et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
protein phosphorylation
inferred from sequence or structural similarity with SGD:S000000364
(Stowers et al., 2000)
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN002373304
(assigned by GO_Central )
(Gaudet et al., 2011)
cytosol
inferred from biological aspect of ancestor with PANTHER:PTN001172735
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000623091
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
posterior midgut primordium
(Sauer et al., 1996)
anterior midgut primordium
(Sauer et al., 1996)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
presumptive embryonic/larval central nervous system
(Sauer et al., 1996)
glial cell
(Sauer et al., 1996)
tracheal precursor cell
(Sauer et al., 1996)
myoblast
(Sauer et al., 1996)
embryonic/larval glial cell
(Sauer et al., 1996)
embryonic stage -- adult stage
(Sauer et al., 1996)
Additional Descriptive Data

Eip63E transcripts are detected at all stages of development on northern blots. They are found to be ubiquitous in early embryos by in situ hybridization. They are also present at a low level throughout the embryo at later stages of embryogenesis. Transient strong signals were observed in a number of tissues. These include the anterior and posterior midguts (in cells rearranging cell-cell contacts), tracheal precursors (during invagination), myoblasts (during fusion), and discrete cells of the CNS (which may be migrating glia).

(Sauer et al., 1996)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{681.P.FSVS-1}Eip63ECPTI001272
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted

Comment: not in mushroom body and central complex

(Knowles-Barley, 2011.8.24)
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Eip63E in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 44 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Eip63E
Transgenic constructs containing regulatory region of Eip63E
Deletions and Duplications ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Eip63E81)
lethal (with Eip63EGN50)
lethal | maternal effect (with Eip63EE1)
lethal | maternal effect (with Eip63EGN50)
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage (with Eip63E81)
lethal - all die before end of P-stage (with Eip63EGN50)
partially lethal - majority die, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable (with Df(3L)1-11)
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
fertile
Other Phenotypes
Allele
developmental rate defective (with Eip63E81)
developmental rate defective (with Eip63EGN50)
flight defective, with Scer\GAL4Mef2.PR
majority die during larval stage (with Eip63E81)
majority die during larval stage (with Eip63EGN50)
small body (with Eip63EE1)
small body (with Eip63EGN50)
small body | pupal stage (with Eip63E81)
small body | pupal stage (with Eip63EGN50)
some die during larval stage | recessive
some die during P-stage (with Eip63E81)
some die during P-stage (with Eip63EGN50)
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage (with Eip63E81)
some die during pupal stage (with Eip63EGN50)
visible, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
head | pupal stage (with Eip63E81)
head | pupal stage (with Eip63EGN50)
leg (with Df(3L)663)
leg | pupal stage (with Eip63E81)
leg | pupal stage (with Eip63EGN50)
mesothoracic tergum, with Scer\GAL4pnr-MD237
myofibril, with Scer\GAL4Mef2.PR
polytene chromosome
pupa (with Eip63E81)
pupa (with Eip63EGN50)
sarcomere, with Scer\GAL4Mef2.PR
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDK14
12 of 15
Yes
Yes
Hsap\CDK15
11 of 15
No
Yes
Hsap\CDK16
4 of 15
No
Yes
Hsap\CDK17
4 of 15
No
Yes
Hsap\CDK18
3 of 15
No
Yes
Hsap\CDK2
2 of 15
No
No
 
Hsap\CDK3
2 of 15
No
No
Hsap\CDK5
2 of 15
No
No
 
Hsap\CDK1
1 of 15
No
No
Hsap\CDK4
1 of 15
No
No
 
Hsap\CDK6
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (12)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdk14
10 of 15
Yes
Yes
Mmus\Cdk15
10 of 15
Yes
Yes
Mmus\Cdk16
4 of 15
No
Yes
Mmus\Cdk17
4 of 15
No
Yes
Mmus\Cdk18
3 of 15
No
Yes
Mmus\Cdk2
2 of 15
No
No
Mmus\Cdk5
2 of 15
No
No
Mmus\Cdk1
1 of 15
No
No
Mmus\Cdk4
1 of 15
No
No
Mmus\Cdk6
1 of 15
No
No
Mmus\E030030I06Rik
1 of 15
No
No
Mmus\Olfr943
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (10)
Rnor\Cdk14
7 of 13
Yes
Yes
Rnor\Cdk17
5 of 13
No
Yes
Rnor\Cdk18
5 of 13
No
Yes
Rnor\Cdk16
4 of 13
No
Yes
Rnor\Cdk1
2 of 13
No
No
Rnor\Cdk2
2 of 13
No
No
Rnor\Cdk5
2 of 13
No
No
Rnor\Cdk4
1 of 13
No
No
Rnor\Cdk6
1 of 13
No
No
Rnor\Cdk15
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\cdk14
10 of 12
Yes
Yes
Xtro\cdk15
5 of 12
No
Yes
Xtro\cdk17
3 of 12
No
Yes
Xtro\cdk16
2 of 12
No
Yes
Xtro\cdk18
2 of 12
No
Yes
Xtro\cdk1
1 of 12
No
No
Xtro\cdk2
1 of 12
No
No
Xtro\cdk4
1 of 12
No
No
Xtro\cdk5
1 of 12
No
No
Xtro\cdk6
1 of 12
No
No
Danio rerio (Zebrafish) (14)
Drer\cdk15
11 of 15
Yes
Yes
Drer\cdk14
9 of 15
No
Yes
Drer\cdk16
4 of 15
No
Yes
Drer\cdk17
4 of 15
No
Yes
Drer\si:dkey-166c18.1
3 of 15
No
Yes
Drer\cdk1
2 of 15
No
No
Drer\cdk2
2 of 15
No
No
Drer\cdk5
2 of 15
No
No
Drer\LOC100536316
2 of 15
No
Yes
Drer\cdk4
1 of 15
No
No
Drer\cdk6
1 of 15
No
No
Drer\cdk21
1 of 15
No
No
Drer\or109-4
1 of 15
No
Yes
Drer\si:ch211-132b12.6
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\ZC123.4
9 of 15
Yes
Yes
Cele\pct-1
5 of 15
No
Yes
Cele\cdk-5
2 of 15
No
No
Cele\cdk-1
1 of 15
No
No
Cele\cdk-2
1 of 15
No
No
Cele\cdk-4
1 of 15
No
No
Cele\ZC487.2
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (7)
Atha\CDC2
1 of 9
Yes
No
Atha\CDKB1;1
1 of 9
Yes
Yes
Atha\CDKB1;2
1 of 9
Yes
No
Atha\CDKB2;1
1 of 9
Yes
Yes
Atha\CDKB2;2
1 of 9
Yes
No
Atha\MPK15
1 of 9
Yes
Yes
Atha\ORG1
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PHO85
6 of 15
Yes
No
Scer\CDC28
2 of 15
No
No
Scer\CAK1
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\pef1
3 of 12
Yes
No
Spom\cdc2
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905UN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Eip63E
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013470
Drosophila simulans
Dsim\GD13773
Drosophila sechellia
Dsec\GM14580
Drosophila erecta
Dere\GG15148
Drosophila yakuba
Dyak\GE21370
Drosophila ananassae
Dana\GF24214
Drosophila pseudoobscura pseudoobscura
Dpse\GA10409
Drosophila persimilis
Dper\GL15117
Drosophila willistoni
Dwil\GK20517
Drosophila virilis
Dvir\GJ12403
Drosophila mojavensis
Dmoj\GI12497
Drosophila grimshawi
Dgri\GH16418
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505MO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17007266
Glossina morsitans
Tsetse fly
Gmor\GMOY003057
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01181
Mayetiola destructor
Hessian fly
Mdes\Mdes002710
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015000
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012915
Anopheles darlingi
American malaria mosquito
Adar\ADAC004645
Anopheles gambiae
Malaria mosquito
Agam\AGAP005729
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008438
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06DD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA011854
Danaus plexippus
Monarch butterfly
Dple\DPOGS201944-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002219
Apis florea
Little honeybee
Aflo\2963320724
Apis mellifera
Western honey bee
Amel\GB44292
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14680
Bombus terrestris
Buff-tailed bumblebee
Bter\15209785
Linepithema humile
Argentine ant
Lhum\LH10792
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000d9b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG024622
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09865
Tribolium castaneum
Red flour beetle
Tcas\TC002523
Pediculus humanus
Human body louse
Phum\PHUM321170
Rhodnius prolixus
Kissing bug
Rpro\RPRC002851
Cimex lectularius
Bed bug
Clec\CLEC004419
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004749
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_12838
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04PW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008911
Strigamia maritima
European centipede
Smar\SMAR008466
Ixodes scapularis
Black-legged tick
Isca\ISCW024673
Ixodes scapularis
Black-legged tick
Isca\ISCW001031
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56853.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56761.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur38g00630
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_299555
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_54893
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CH0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pctaire
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_001227gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pftaire-1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cdk2_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006693
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005978
Ciona intestinalis
Vase tunicate
Cint\LOC100182544
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000009174
Gallus gallus
Domestic chicken
Ggal\CDK17
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027196
Gallus gallus
Domestic chicken
Ggal\CDK14
Gallus gallus
Domestic chicken
Ggal\CDK15
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028442
Gallus gallus
Domestic chicken
Ggal\CDC2
Gallus gallus
Domestic chicken
Ggal\CDK3
Gallus gallus
Domestic chicken
Ggal\CDK18
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cdk1
3 of 10
Cdk2
3 of 10
Cdk5
3 of 10
Cdk4
2 of 10
Cdc2rk
1 of 10
Cdk7
1 of 10
Cdk8
1 of 10
Cdk9
1 of 10
Cdk12
1 of 10
CG6800
1 of 10
CG7028
1 of 10
CG7236
1 of 10
Pitslre
1 of 10
Pk34A
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CDK14; cyclin dependent kinase 14
    12 of 15
    610679
        CDK15; cyclin dependent kinase 15
        11 of 15
        616147
            CDK16; cyclin dependent kinase 16
            4 of 15
            311550
                CDK17; cyclin dependent kinase 17
                4 of 15
                603440
                    CDK18; cyclin dependent kinase 18
                    3 of 15
                    169190
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        esyN Network Diagram
                        Show neighbor-neighbor interactions:
                        Select Layout:
                        Legend:
                        Protein
                        RNA
                        Selected Interactor(s)
                        Interactions Browser
                        View in Interactions Browser
                        Please see the Physical Interaction reports below for full details
                        protein-protein
                        Physical Interaction
                        Assay
                        References
                        Eip63E - CycC
                        two hybrid
                        (Liu and Finley, 2010)
                        Eip63E - CycY
                        anti tag coimmunoprecipitation, anti tag western blot, two hybrid
                        (Liu and Finley, 2010)
                        Eip63E - Raf
                        anti tag coimmunoprecipitation, peptide massfingerprinting
                        (Friedman et al., 2011)
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        External Data
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        External Data
                        Linkouts
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        3L
                        Recombination map

                        3-8

                        Cytogenetic map
                        63E3-63E5
                        Sequence location
                        3L:3,515,751..3,610,521 [+]
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        63E3-63E5
                        Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        63E-63E
                        (Lehner, 1996.7.23)
                        63E-63E
                        (determined by in situ hybridisation)
                        (Sauer et al., 1996)
                        Experimentally Determined Recombination Data
                        Location

                        3-8

                        (FlyBase, 2016)

                        3-7.1

                        (Comeron et al., 2012)

                        3-

                        (Lehner, 1996.7.23)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (21)
                        Genomic Clones (74)
                        cDNA Clones (318)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequences
                        BDGP DGC clones
                        Other clones
                        Drosophila Genomics Resource Center cDNA clones

                        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                        cDNA Clones, End Sequenced (ESTs)
                        BDGP DGC clones
                        Other clones
                        RNAi and Array Information
                        Linkouts
                        DRSC - Results frm RNAi screens
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        Antibody Information
                        Laboratory Generated Antibodies
                         
                        Commercially Available Antibodies
                         
                        Other Information
                        Relationship to Other Genes
                        Source for database identify of

                        Source for identity of: Eip63E CG10579

                        (Li, 1999.11)
                        Source for database merge of

                        Source for merge of: Eip63E Pftaire

                        (Munroe et al., 1998.5.12)
                        Additional comments
                        Other Comments

                        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in mitotic index is seen.

                        (Bettencourt-Dias et al., 2004)

                        Eip63E is required not only for metamorphosis, but also maternally and for embryonic and larval development.

                        (Stowers et al., 2000)

                        Characterisation of Eip63E.

                        (Sauer et al., 1996)
                        Origin and Etymology
                        Discoverer
                        Etymology
                        Identification
                        External Crossreferences and Linkouts ( 123 )
                        Sequence Crossreferences
                        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                        Other crossreferences
                        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                        Flygut - An atlas of the Drosophila adult midgut
                        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                        InterPro - A database of protein families, domains and functional sites
                        KEGG Genes - Molecular building blocks of life in the genomic space.
                        modMine - A data warehouse for the modENCODE project
                        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                        Linkouts
                        BioGRID - A database of protein and genetic interactions.
                        DroID - A comprehensive database of gene and protein interactions.
                        DRSC - Results frm RNAi screens
                        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                        FlyMine - An integrated database for Drosophila genomics
                        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Synonyms and Secondary IDs (8)
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        References (111)