L63, PFTAIRE, cdc2-63E
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
3.4 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Eip63E using the Feature Mapper tool.
Eip63E transcripts are detected at all stages of development on northern blots. They are found to be ubiquitous in early embryos by in situ hybridization. They are also present at a low level throughout the embryo at later stages of embryogenesis. Transient strong signals were observed in a number of tissues. These include the anterior and posterior midguts (in cells rearranging cell-cell contacts), tracheal precursors (during invagination), myoblasts (during fusion), and discrete cells of the CNS (which may be migrating glia).
GBrowse - Visual display of RNA-Seq signalsView Dmel\Eip63E in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in mitotic index is seen.
Eip63E is required not only for metamorphosis, but also maternally and for embryonic and larval development.