• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Eip63E

General Information
Symbol	Dmel\Eip63E	Species	D. melanogaster
Name	Ecdysone-induced protein 63E	Annotation symbol	CG10579
Feature type	protein_coding_gene	FlyBase ID	FBgn0005640
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	L63, cdc2-63E
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	63E3-63E5	Sequence location	3L:3,515,751..3,610,521 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ecdysone-induced protein 63E is referred to in FlyBase by the symbol Dmel\Eip63E (CG10579, FBgn0005640). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cyclin-dependent protein serine/threonine kinase activity; cyclin binding; protein binding; protein kinase activity. There is experimental evidence that it is involved in the biological process: morphogenesis of an epithelium; instar larval development; developmental growth; embryonic development via the syncytial blastoderm; metamorphosis; protein phosphorylation. 53 alleles are reported. The phenotypes of these alleles are annotated with: pupa; leg; polytene chromosome; mesothoracic tergum. It has 14 annotated transcripts and 14 annotated polypeptides. Protein features are: Cytochrome b5, heme-binding site; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine- / dual specificity protein kinase, catalytic domain; Serine/threonine-protein kinase, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult Malpighian tubules, adult salivary gland, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626138_s_at completely aligns to an exonic region common to each of the 13 FlyBase-annotated transcript isoforms of Eip63E. Gene sequence location is 3L:3515751..3610521.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles Eip63E[MI08026]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63E3-63E5   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63E-63E     (Lehner, 1996.7.23) 63E-63E   (determined by in situ hybridisation)   (Sauer et al., 1996)
Experimentally Determined Recombination Data
Location	3- (Lehner, 1996.7.23)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Eip63E for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Stop-codon suppression (UGA) postulated; FBrf0216884. gene_with_stop_codon_read_through ; SO:0000697 Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Eip63E-RA FBtr0073133  NM_168034   2700   509 Eip63E-RB FBtr0073134  NM_168035   2919   509 Eip63E-RC FBtr0073135  NM_168036   2891   509 Eip63E-RD FBtr0073131  NM_079180   3575   522 Eip63E-RE FBtr0073132  NM_168033   2981   522 Eip63E-RF FBtr0110920  NM_001043116   3536   509 Eip63E-RG FBtr0110921  NM_001043120   2958   522 Eip63E-RH FBtr0110922  NM_001043117   2625   501 Eip63E-RI FBtr0110923  NM_001043119   2739   522 Eip63E-RJ FBtr0110924  NM_001043121   4769   509 Eip63E-RK FBtr0110925  NM_001043118   2930   522 Eip63E-RL FBtr0301948  NM_001169869   3311   522 Eip63E-RM FBtr0302598  NM_001202113   4914   509 Eip63E-RN FBtr0330068  NM_001274444   3575   538
Additional Transcript Data & Comments
Reported size (kB)	3.4 (northern blot) (Sauer et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Eip63E-PA   FBpp0072992   58.5   509   8.88     NP_728889   AAG22238 Eip63E-PB   FBpp0072993   58.5   509   8.88     NP_728890   AAF47781 Eip63E-PC   FBpp0072994   58.5   509   8.88     NP_728891   AAG22239 Eip63E-PD   FBpp0072990   59.8   522   8.87     NP_523904   AAN11568 Eip63E-PE   FBpp0072991   59.8   522   8.87     NP_728888   AAN11569 Eip63E-PF   FBpp0110220   58.3   509   8.88     NP_001036581   ABI31232 Eip63E-PG   FBpp0110221   59.9   522   8.87     NP_001036585   ABI31236 Eip63E-PH   FBpp0110222   57.7   501   8.88     NP_001036582   ABI31233 Eip63E-PI   FBpp0110223   59.9   522   8.87     NP_001036584   ABI31235 Eip63E-PJ   FBpp0110224   58.5   509   8.88     NP_001036586   ABI31237 Eip63E-PK   FBpp0110225   59.9   522   8.87     NP_001036583   ABI31234 Eip63E-PL   FBpp0291160   59.9   522   8.87     NP_001163340   ACZ94612 Eip63E-PM   FBpp0291754   58.3   509   8.88     NP_001189042   ADV37479 Eip63E-PN   FBpp0303101   61.6   538   9.03     NP_001261373   AGB94068
Additional Polypeptide Data & Comments
Reported size (kDa)	509 (aa) (Sauer et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b5, heme-binding site (IPR018506) Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA440316   AA539000   AA539887   AA567397   AA696968   AA697537   AA698266   AA698406   AA698820   AA699286   AA949110   AE014296 AAF47781   AE014296 AAG22238   AE014296 AAG22239   AE014296 AAN11568   AE014296 AAN11569   AE014296 ABI31232   AE014296 ABI31233   AE014296 ABI31234   AE014296 ABI31235   AE014296 ABI31236   AE014296 ABI31237   AE014296 ACZ94612   AE014296 ADV37479   AF152398 AAD45509   AF152399 AAD45510   AF152400 AAD45511   AF152401 AAD45512   AF152402 AAD45513   AF152403 AAD45514   AF152404 AAD45515   AF152405 AAD45516   AF152406 AAD45517   AE014296 AGB94068   AI063351   AI063381   AI107689   AI107943   AI113444   AI134977   AI238030   AI238172   AI257291   AI257513   AI257550   AI257730   AI258857   AI259834   AI259889   AI260504   AI261152   AI293168   AI294011   AI294193   AI294391   AI295519   AI297186   AI387585   AI404153   AI406131   AI514920   AI516928   AI517017   AI517325   AI531608   AI532745   AI534123   AI534273   AI534592   AI534743   AI534930   AI542234   AI542235   AI543088   AI543200   AI543455   AI546650   AW942344   AY089650   AY089662   AY113367 AAM29372   AY310908 AAQ20873   BG632011   BG632325   BG635473   BG636039   BI167919   BI168019   BI168164   BI170293   BI170847   BI172908   BI214816   BI215283   BI215374   BI216285   BI227597   BI227635   BI231111   BI236401   BI237587   BI238254   BI239895   BI363450   BI363513   BI372395   BI374263   BI482625   BI482661   BI565498   BI567733   BI571083   BI572036   BI572114   BI577403   BI577737   BI579330   BI583498   BI584544   BI587999   BI588462   BI589204   BI592160   BI606034   BI611279   BI613115   BI613209   BI613274   BI613581   BI616841   BI617077   BI623047   BI628351   BI628385   BI628593   BI629126   BI632500   BI633327   BI633715   BI633762   BI635066   BI635340   BI635522   BI635529   BI635690   BI635718   BI635939   BI636187   BI637349   BI637631   BI637753   BI638148   BI638154   BI641482   BI641727   BP547468   BP559265   BT010064 AAQ22533   BT022123   BT099741   BT099928   CA804868   CA805371   CA807148   CK131504   CK132192   CK132232   CK656963   CK657249   CK657590   CK659243   CK659578   CK659590   CK659681   CK660732   CK661116   CK661571   CK661903   CK661941   CK662076   CK662307   CK662482   CL844437   CL943534   CO152658   CO152869   CO152948   CO153471   CO153526   CO154046   CO154126   CO154219   CO154251   CO154640   CO154642   CO154705   CO154880   CO154925   CO155543   CO155685   CO156291   CO156474   CO156813   CO156877   CO178635   CO178672   CO180964   CO181280   CO186254   CO190724   CO191094   CO263795   CO264296   CO266201   CO268577   CO268728   CO268743   CO269656   CO270000   CO270677   CO271036   CO276003   CO279466   CO279675   CO282479   CO282906   CO284181   CO286681   CO286714   CO287459   CO288808   CO289537   CO296124   CO298711   CO301922   CO302264   CO302522   CO306559   CO307797   CO309828   CO310679   CO312958   CO314065   CO314448   CO316481   CO317136   CO317688   CO320256   CO321933   CO322056   CO322058   CO323368   CO327020   CO328741   CO328782   CO328783   CO328834   CO329473   CO329543   CO332168   CO333135   CO335567   CO335609   CO336076   CO336208   CO336590   CO337039   CO337559   CO337612   CO337826   CO337915   CO338185   CO338385   CO338387   CO338436   CO338454   CO338470   CO338543   CO340164   CO340812   CO341564   CO342197   CO342403   CO343801   CO345334   CZ466821   CZ466822   CZ467682   CZ467683   CZ473100   CZ475719   CZ476773   CZ477926   CZ477927   CZ478837   CZ479153   CZ480911   CZ487809   EC055453   EC056336   EC060710   EC060853   EC062529   EC064243   EC065597   EC069488   EC069911   EC070973   EC071221   EC078630   EC081167   EC087578   EC194462   EC198301   EC200314   EC202981   EC205244   EC206187   EC206188   EC206661   EC206708   EC207690   EC208727   EC211761   EC214196   EC217951   EC217960   EC218299   EC222783   EC233059   EC236482   EC239823   EC240893   EC241695   EC244090   EC245492   EC248627   EC250280   EC251064   EC255972   EC264479   EC267022   EL873515   EL878932   EV580103   EV585649   GH762500   GH941676   GH943115   GH944741   GH945094   GH946063   GH948288   GH949766   GH952032   GH952857   GH954230   GH955829   GH956131   GH958717   GH962300   GH962659   GH962864   GH965767   GH967913   GH969016   GH971152   GH973816   GH974237   GH974455   GH976588   GH977760   GH978841   X99512 CAA67862
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KM03 Q7KM04 Q7KM08 Q9XTK9 Q7KM05 Q8MZ44 Q7YUC0 Q94888
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   posterior midgut primordium   (Sauer et al., 1996) anterior midgut primordium   (Sauer et al., 1996) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system   (Sauer et al., 1996) glial cell   (Sauer et al., 1996) tracheal precursor cell   (Sauer et al., 1996) myoblast   (Sauer et al., 1996) embryonic/larval glial cell   (Sauer et al., 1996) embryonic stage -- adult stage     (Sauer et al., 1996)
Additional Descriptive Data
	Eip63E transcripts are detected at all stages of development on northern blots. They are found to be ubiquitous in early embryos by in situ hybridization. They are also present at a low level throughout the embryo at later stages of embryogenesis. Transient strong signals were observed in a number of tissues. These include the anterior and posterior midguts (in cells rearranging cell-cell contacts), tracheal precursors (during invagination), myoblasts (during fusion), and discrete cells of the CNS (which may be migrating glia). (Sauer et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval hindgut, adult Malpighian tubules, adult salivary gland, larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut    668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea    1124.625 Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules    560.8 Adult Fat Body    273 Adult Salivary Gland    1463.4 Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut  (668.5) Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea  (1124.625) Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules  (560.8) Adult Fat Body    273 Adult Salivary Gland  (1463.4) Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut    668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea  (1124.625) Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules    560.8 Adult Fat Body    273 Adult Salivary Gland  (1463.4) Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut    668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea    1124.625 Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules    560.8 Adult Fat Body    273 Adult Salivary Gland    1463.4 Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut    668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea    1124.625 Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules    560.8 Adult Fat Body    273 Adult Salivary Gland    1463.4 Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut  668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea  (1124.625) Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules  560.8 Adult Fat Body    273 Adult Salivary Gland  (1463.4) Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut    668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea  1124.625 Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules    560.8 Adult Fat Body    273 Adult Salivary Gland  1463.4 Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    250.15 Larval Midgut    194.5 Larval Hindgut    668.5 Larval Malpighian Tubules    413.3 Larval Fat Body    454.1 Larval Salivary Gland    203.4 Larval Trachea    1124.625 Larval Carcass    389.075 Adult Head    204.7 Adult Eye    356.55 Adult Brain    295.4 Adult Thoracic-Abdominal Ganglion    284.5 Adult Crop    305.8 Adult Midgut    379.2 Adult Hindgut    309.5 Adult Malpighian Tubules    560.8 Adult Fat Body    273 Adult Salivary Gland    1463.4 Adult Heart    221.85 Adult VirginFemale Spermatheca    346 Adult InseminatedFemale Spermatheca    403 Adult Ovary    411.3 Adult Testis    164.8 Adult Male Accessory Gland    132.8 Adult Carcass    139.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    204.7   NA  Eye    356.55   NA  Brain    295.4   250.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    284.5   NA  Crop    305.8   194.5  Midgut    379.2   668.5  Hindgut    309.5   413.3  Malpighian Tubules    560.8   454.1  Fat Body    273   203.4  Salivary Gland    1463.4   NA  Heart    221.85   1124.625  Trachea    NA   NA  VirginFemale Spermatheca    346   NA  InseminatedFemale Spermatheca    403   NA  Ovary    411.3   NA  Testis    164.8   NA  Male Accessory Gland    132.8   389.075  Carcass    139.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8    30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    206 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8  (30) head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae  (206) digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8    30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae  (206) digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8    30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    206 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8    30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    206 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8  30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae  (206) digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8    30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae  (206) digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    15 central nervous system, pupae P8    30 head, virgin 1-day female    11 head, virgin 4-day female    9 head, virgin 20-day female    8 head, mated 1-day female    10 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    206 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    17 carcass, larvae L3 wandering    13 carcass, 1-day adult    5 carcass, 4-day adult    4 carcass, 20-day adult    4 ovary, virgin 4-day female    15 ovary, mated 4-day female    13 testis, mated 4-day male    9 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new  (31) white prepupae 12hr  (38) white prepupae 24hr  (27) pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new  31 white prepupae 12hr  (38) white prepupae 24hr  27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    17 embryo 02-04hr    19 embryo 04-06hr    17 embryo 06-08hr    20 embryo 08-10hr    22 embryo 10-12hr    23 embryo 12-14hr    24 embryo 14-16hr    25 embryo 16-18hr    24 embryo 18-20hr    18 embryo 20-22hr    19 embryo 22-24hr    19 larva L1    10 larva L2    6 larva L3 12hr old    7 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    18 white prepupae new    31 white prepupae 12hr    38 white prepupae 24hr    27 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    15 adult male 01day    11 adult male 05day    12 adult male 30day    14 adult female 01day    11 adult female 05day    12 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    46 Schneider line 2 Sg4    19 embryonic 1182-4H    32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8    46 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (46) Schneider line 2 Sg4    19 embryonic 1182-4H  (32) embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8  (46) wing disc ML-DmD9  (29) wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (29) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (45) eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1  (54) CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2  (29) ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    46 Schneider line 2 Sg4    19 embryonic 1182-4H    32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8    46 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    46 Schneider line 2 Sg4    19 embryonic 1182-4H    32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8    46 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    46 Schneider line 2 Sg4    19 embryonic 1182-4H    32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8    46 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (46) Schneider line 2 Sg4    19 embryonic 1182-4H  32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8  (46) wing disc ML-DmD9  29 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (45) eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5  26 mixed discs ML-DmD4-c1  (54) CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2  29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    46 Schneider line 2 Sg4    19 embryonic 1182-4H    32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8    46 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    46 Schneider line 2 Sg4    19 embryonic 1182-4H    32 embryonic GM2    9 embryonic Kc167    24 embryonic S1    9 embryonic S3    17 leg disc CME L1    14 wing disc CME-W2    17 wing disc ML-DmD8    46 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    29 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    45 eye-antennal disc ML-DmD11    12 antennal disc ML-DmD20-c5    26 mixed discs ML-DmD4-c1    54 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    6 tumorous blood cells mbn2    29 ovary fGS/OSS    14 ovary OSC    13 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    12 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    9 Paraquat 5 mM 48 hrs, 4-day adult    11 Paraquat 10 mM 48 hrs, 4-day adult    12 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • PC00122 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005640 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10038-RB;CG10579-RD FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Eip63E Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Eip63E1 Eip63E15 Eip63E29 Eip63E33 lethal | larval stage | recessive Eip63E81 lethal | maternal effect (with Eip63EE1) Eip63EGN50 lethal | maternal effect (with Eip63EGN50) Eip63EE1 lethal | polyphasic (with Eip63E81) Eip63EGN50 lethal | polyphasic (with Eip63EE1) Eip63EGN50 lethal | polyphasic (with Eip63EGN50) Eip63E81 Eip63EE1 lethal | P-stage (with Eip63E81) Eip63EGN50 lethal | P-stage (with Eip63EGN50) Eip63E81 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Eip63EGD16928 viable Eip63ECA06742 Eip63EEY11305 Eip63EEY12371 viable (with Df(3L)1-11) Eip63EGN50 Sterility Allele fertile Eip63EEY11305 Eip63EEY12371 Other Phenotypes Allele developmental rate defective (with Eip63E81) Eip63EGN50 developmental rate defective (with Eip63EGN50) Eip63E81 small body (with Eip63EE1) Eip63EGN50 small body (with Eip63EGN50) Eip63EE1 small body | pupal stage (with Eip63E81) Eip63EGN50 small body | pupal stage (with Eip63EGN50) Eip63E81 visible, with Scer\GAL4pnr-MD237 Eip63EGD16928 wild-type Eip63EB1.hs Phenotype manifest in Allele head | pupal stage (with Eip63E81) Eip63EGN50 head | pupal stage (with Eip63EGN50) Eip63E81 leg (with Df(3L)663) Eip63E81 leg | pupal stage (with Eip63E81) Eip63EGN50 leg | pupal stage (with Eip63EGN50) Eip63E81 mesothoracic tergum, with Scer\GAL4pnr-MD237 Eip63EGD16928 polytene chromosome Eip63ECC Eip63EE1 Eip63EFF Eip63EO pupa (with Eip63E81) Eip63EGN50 pupa (with Eip63EGN50) Eip63E81
Classical Alleles ( 42 )
For All Classical Alleles Show
Allele of Eip63E Class Mutagen Stocks Known lesion Eip63E81 ethyl methanesulfonate 1 Yes Eip63EA310 1 -- Eip63EB417 1 -- Eip63Ec01027 piggyBac transposase 1 -- Eip63Ec02102 piggyBac transposase 1 -- Eip63EC107 1 -- Eip63Ed02960 P-element activity 1 -- Eip63Ed09231 1 -- Eip63Ee00017 piggyBac transposase 1 -- Eip63Ee01010 piggyBac transposase 1 -- Eip63Ee01346 piggyBac transposase 1 -- Eip63EEP3656 P-element activity 1 -- Eip63Ef05185 piggyBac transposase 1 -- Eip63EMI00413 1 -- Eip63EMI02792 1 -- Eip63EMI03882 1 -- Eip63EMI04853 1 -- Eip63E15 0 -- Eip63E1619 0 -- Eip63E1 0 -- Eip63E204h2 0 -- Eip63E2266 0 -- Eip63E29 0 -- Eip63E33 0 -- Eip63E33D3 P-element activity 0 -- Eip63ECA06742 P-element activity 0 Yes Eip63ECC 0 Yes Eip63ECPTI001272 piggyBac transposase 0 Yes Eip63Ed07418 P-element activity 0 -- Eip63Ed09499 P-element activity 0 -- Eip63EDG06102 0 -- Eip63EDG09809 0 -- Eip63Ee03147 piggyBac transposase 0 -- Eip63EE1 0 Yes Eip63EEP3460 0 -- Eip63EEY11305 P-element activity 0 -- Eip63EEY12371 P-element activity 0 -- Eip63EFF 0 Yes Eip63EGN50 0 Yes Eip63EMI08026 0 -- Eip63EO 0 Yes Eip63Eunspecified 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Eip63E Class Mutagen Stocks Known lesion Eip63EGD16928 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Eip63EGL00147 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Eip63EHM05111 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Eip63EHMS00569 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Eip63EKK108615 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Eip63EB1.hs in vitro construct - regulatory fusion 0 Yes Eip63EB1.Δ202.hs in vitro construct - deletion 0 Yes Eip63EE251Q.hs in vitro construct - amino acid replacement 0 Yes Eip63EG243A.hs in vitro construct - amino acid replacement 0 Yes Eip63EI249L.hs in vitro construct - amino acid replacement 0 Yes Eip63ENIG.10579R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Eip63ES359A.hs in vitro construct - amino acid replacement 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)294 (Munroe et al., 1998.5.12) Df(3L)663 (Munroe et al., 1998.5.12) Df(3L)E1 (Munroe et al., 1998.5.12)
Not disrupted in	Df(3L)1-11 (Munroe et al., 1998.5.12) Df(3L)GN34 (Munroe et al., 1998.5.12) Df(3L)GN50 (Munroe et al., 1998.5.12) Df(3L)HR232 (Munroe et al., 1998.5.12)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD16928} NA P{KK108615} NA P{NIG.10579R} NA P{TRiP.GL00147} NA P{TRiP.HM05111} NA P{TRiP.HMS00569} NA heat-shock construct P{hs-Eip63E.E251Q} NA P{hs-Eip63E.G243A} NA P{hs-Eip63E.I249L} NA P{hs-Eip63E.S359A} NA P{hs-L63B1.Δ202} NA P{hs-L63B1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Eip63EEP3460 NA P{EP}Eip63EEP3656 NA P{EPgy2}Eip63EEY12371 NA P{EPgy2}snRNA:U7EY11305 NA P{XP}Eip63Ed02960 NA P{XP}Eip63Ed07418 NA P{XP}Eip63Ed09231 NA P{XP}Eip63Ed09499 NA miscellaneous insertions Mi{MIC}Eip63EMI00413 NA Mi{MIC}Eip63EMI02792 NA Mi{MIC}Eip63EMI03882 NA Mi{MIC}Eip63EMI04853 NA Mi{MIC}Eip63EMI08026 NA P{PTT-GA}Eip63ECA06742 NA P{wHy}Eip63EDG06102 NA P{wHy}Eip63EDG09809 NA PBac{3HPy+}Eip63EC107 NA PBac{5HPw+}Eip63EA310 NA PBac{5HPw+}Eip63EB417 NA PBac{681.P.FSVS-1}Eip63ECPTI001272 NA PBac{PB}Eip63Ec01027 NA PBac{PB}Eip63Ec02102 NA PBac{RB}Eip63Ee00017 NA PBac{RB}Eip63Ee01010 NA PBac{RB}Eip63Ee01346 NA PBac{RB}Eip63Ee03147 NA PBac{WH}Eip63Ef05185 NA insertion of enhancer trap P{lacW}Eip63E33D3 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
cyclin binding inferred from mutant phenotype (Stowers et al., 2000) cyclin-dependent protein serine/threonine kinase activity inferred from mutant phenotype AND inferred from sequence or structural similarity with Saccharomyces CDC28 (Stowers et al., 2000) protein binding inferred from physical interaction with Pif1B (Rascle et al., 2003) inferred from physical interaction with Pif2 (Rascle et al., 2003) protein kinase activity inferred from direct assay (Rascle et al., 2003)
Biological Process
CV term Evidence References
developmental growth inferred from mutant phenotype (Liu and Finley, 2010) embryonic development via the syncytial blastoderm inferred from mutant phenotype (Stowers et al., 2000) instar larval development inferred from mutant phenotype (Stowers et al., 2000) metamorphosis inferred from mutant phenotype (Stowers et al., 2000) morphogenesis of an epithelium inferred from mutant phenotype (Stowers et al., 2000) protein phosphorylation inferred from direct assay (Rascle et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cyclin-dependent protein serine/threonine kinase activity inferred from sequence or structural similarity (Sauer et al., 1996) heme binding inferred from electronic annotation with InterPro:IPR018506 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity (Swiss-Prot Project Members, 1997.2.1) inferred from sequence or structural similarity with EMBL:U62391 (FlyBase, 1992-) non-traceable author statement (Lehner, 1996.7.23, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from sequence or structural similarity (Swiss-Prot Project Members, 1997.2.1) inferred from sequence or structural similarity with Saccharomyces CDC28 (Stowers et al., 2000) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Eip63E allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63926 DroID - A comprehensive database of gene and protein interactions. • FBgn0005640 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38433 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7KM03
Orthologs
OrthoDB Orthologs (70) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FR1B8 Dipteran inclusive ortholog search EOG6KSPT3 Insect inclusive ortholog search EOG6FXQ3S Arthropod inclusive ortholog search EOG6BNZT1 Metazoa inclusive ortholog search EOG6PGJT5
Orthologs in Drosophila Species (EOG6FR1B8)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Eip63E     Drosophila simulans   Dsim\GD13773 Y   Drosophila sechellia   Dsec\GM14580 Y   Drosophila erecta   Dere\GG15148 Y   Drosophila yakuba   Dyak\GE21370 Y   Drosophila ananassae   Dana\GF24214 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10409 Y   Drosophila persimilis   Dper\GL15117 Y   Drosophila willistoni   Dwil\GK20517 Y   Drosophila virilis   Dvir\GJ12403 Y   Drosophila mojavensis   Dmoj\GI12497 Y   Drosophila grimshawi   Dgri\GH16418 Y
Orthologs in non-Drosophila Dipterans (EOG6KSPT3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015000   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012915   Anopheles gambiae Malaria mosquito  Agam\AGAP005729   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008438
Orthologs in non-Dipteran Insects (EOG6FXQ3S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB44292   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG024622   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10616   Atta cephalotes Leafcutter ant  Acep\ACEP10293   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15187   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22329   Linepithema humile Argentine ant  Lhum\LH10792   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17661   Solenopsis invicta Red fire ant  Sinv\SINV13855   Acyrthosiphon pisum Pea aphid  Apim\ACYPI004749   Bombyx mori Silkmoth  Bmor\BGIBMGA011854   Pediculus humanus Human body louse  Phum\PHUM321170   Tribolium castaneum Red flour beetle  Tcas\TC002523
Orthologs in non-Insect Arthropods (EOG6BNZT1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Morc2b
Orthologs in non-Arthropod Metazoa (EOG6PGJT5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\ZC123.4 Y Caenorhabditis elegans Nematode  Cele\cdk-5 Y Caenorhabditis elegans Nematode  Cele\pct-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016385gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003654gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017705gn Y Danio rerio Zebrafish  Drer\cdk15 Y Danio rerio Zebrafish  Drer\cdk16 Y Danio rerio Zebrafish  Drer\zgc:172096 Y Danio rerio Zebrafish  Drer\ENSDARG00000012204 Y Danio rerio Zebrafish  Drer\cdk5 Y Danio rerio Zebrafish  Drer\ENSDARG00000063721 Y Danio rerio Zebrafish  Drer\cdk16 Y Xenopus tropicalis Western clawed frog  Xtro\cdk16 Y Xenopus tropicalis Western clawed frog  Xtro\cdk14 Y Xenopus tropicalis Western clawed frog  Xtro\cdk17 Y Xenopus tropicalis Western clawed frog  Xtro\cdk5 Y Xenopus tropicalis Western clawed frog  Xtro\cdk15 Y Xenopus tropicalis Western clawed frog  Xtro\cdk18 Y Gallus gallus Domestic chicken  Ggal\CDK17 Y Gallus gallus Domestic chicken  Ggal\CDK14 Y Gallus gallus Domestic chicken  Ggal\CDK15 Y Gallus gallus Domestic chicken  Ggal\CDK18 Y Mus musculus House mouse  Mmus\Cdk5 Y Mus musculus House mouse  Mmus\Cdk18 Y Mus musculus House mouse  Mmus\Cdk16 Y Mus musculus House mouse  Mmus\Cdk14 Y Mus musculus House mouse  Mmus\Cdk17 Y Mus musculus House mouse  Mmus\Cdk15 Y Rattus norvegicus Norway rat  Rnor\Fzd7 Y Rattus norvegicus Norway rat  Rnor\Cdk5 Y Rattus norvegicus Norway rat  Rnor\Cdk17 Y Rattus norvegicus Norway rat  Rnor\Cdk18 Y Rattus norvegicus Norway rat  Rnor\Pftk1_predicted Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000008578 Y Homo sapiens Human  Hsap\CDK16 Y Homo sapiens Human  Hsap\CDK5 Y Homo sapiens Human  Hsap\CDK17 Y Homo sapiens Human  Hsap\CDK14 Y Homo sapiens Human  Hsap\ENSG00000117266 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\CDK16     Hsap\CDK5     Hsap\CDK17     Hsap\CDK14     Hsap\ENSG00000117266
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13773 Drosophila sechellia Dsec\GM14580 Drosophila erecta Dere\GG15148 Drosophila yakuba Dyak\GE21370 Drosophila ananassae Dana\GF24214 Drosophila pseudoobscura pseudoobscura Dpse\GA10409 Drosophila persimilis Dper\GL15117 Drosophila willistoni Dwil\GK20517 Drosophila virilis Dvir\GJ12403 Drosophila mojavensis Dmoj\GI12497 Drosophila grimshawi Dgri\GH16418
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Harvard	- P{XP}Eip63Ed02960 - P{XP}Eip63Ed09231 - PBac{PB}Eip63Ec01027 - PBac{PB}Eip63Ec02102 - PBac{RB}Eip63Ee00017 - PBac{RB}Eip63Ee01010 - PBac{RB}Eip63Ee01346 - PBac{WH}Eip63Ef05185
VDRC	v106824 P{KK108615}VIE-260B v47860 w1118; P{GD16928}v47860 v47859 w1118; P{GD16928}v47859/CyO v50599 w1118; P{GD16928}v50599/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR09B04 BACR22N09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 329 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP09007 LD15250 LD27880 RH07382 RH25742 RH42523
Other clones	GH02721
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01350 GH03103 GH03155 GH05506 GH05843 GH06559 GH09708 GH12578 GH14012 GH14173 GH16278 GH18146 GH23761 GH26336 GH27532 GH27637 GH28037 GM08816 HL01126 HL02733 HL04073 HL04417 HL05751 HL08090 LD18691 LD19179 LD46554 LP02153 LP03339 LP03409 LP04393 LP05285 LP05607 LP05910 LP05952 LP06184 LP06726 LP07291 LP07513 LP07752 LP09178 LP11433 LP13525 LP13593 LP16868 LP17435 LP17453 LP17610 LP19559 LP20276 LP21169 LP21694 LP21767 LP22030 LP22404 LP22737 LP22842 LP23389 LP24008 RE08421 RE08551 RE08733 RE11690 RE12447 RE15610 RE19305 RE20945 RE21644 RE21758 RE23270 RE24691 RE24739 RE32451 RE33836 RE34661 RE36512 RE48262 RE48340 RE59347 RE61810 RE65339 RE65378 RE71071 RE71462 RE73347 RH05901 RH07371 RH07451 RH09786 RH17463 RH22126 RH23770 RH28968 RH29693 RH31563 RH38292 RH42193 RH42315 RH42390 RH42765 RH46938 RH47292 RH55113 RH56721 RH56761 RH57068 RH57941 RH63278 RH72114 SD01220 SD02728 SD04346 SD06638 SD07044 SD07502 SD07749 SD08394 SD08395 SD09683 SD09826 SD09891 SD10211 SD12885 SD13621 SD16303 SD16663 SD16891 SD16902 SD17116 SD17158 SD17481 SD17786 SD19335 SD19684 SD19822 SD20365 SD20373 SD24831 SD25303 SD26294 SD27390 SD27862 SD27919
Other clones	16151 20710 20753 20765 29353 45549 52705 54853 59131 60646 80197 97131 99844 108413 117401 118925 120215 174319 178200 214405.1 274489 274982 280821 475297 569451 CK01.6A.A6 CK01.20D.G1 CK01.31A.E6 CK01.35D.F7 CK01.36A.G12 CK01.38D.C7 CK01.41A.D1 CK01.60C.B6 CK01.72B.A12 CK01.72B.F3 CK01.79A.E4 CK01.90D.G10 CK01.110D.C2 CK01.125A.E10 CK01.128C.F10 Dmel_dig_007780_0681_3448 Dmel_dig_015371_0641_0711 EC13256 EC13949 EC055453 EC056336 EK017809 EK049360 EK050715 EK057236 EK057322 EK063544 EK063639 EK065917 EK069419 EK071257 EK092013 EK092525 EK092554 EK095451 EK097106 EK099753 EK101641 EK119362 EK134361 EK135621 EK136446 EK138432 EK145310 EK160555 EK161741 EK165436 EK173548 EK182718 EK183755 EK184335 EK186825 EK187122 EK187125 EK190327 EK212755 EK219439 EK222259 EK230808 EK234918 EK236460 EK251433 EK255703 EK265047 EK267205 EK268810 EK283138 EK291309 EK291413 EK291414 EK291506 EK292926 EK293060 EK302658 EK305835 EN00108 EN00631 EN00908 EN02032 EN02304 EN03353 EN03539 EN03733 EN03807 EN04520 EN04522 EN04631 EN04955 EN05038 EN06303 EN06551 EN07757 EN08131 EN09346 EN09462 EN10733 EN10825 EN11755 EN12050 EN12838 EN13714 EN14810 EN14921 EN15355 EN15558 EN16131 EN16663 EN16703 EN16812 EN16836 EN16858 EN17040 EP05516 EP10131 EP11407 EP12661 EP14135 EP14838 EP18056 EP21843 ESG016c.E21_A05 ESG0115c.B21_D01 ESG0117d.B21_G04 FGH117C07 FGM319H03 IP05361 IP08807 RP001051314 RP004025441 RP004085033 RP004090574 RP004117999 RP004138473 RP004149759 RP004180115 RP004197706 RP004222359 RP004233896 RP004238151 RP004253501 RP004256815 RP004264960 RP004279791 RP004315650 RP004362649 RP004367676 RP004375090 RP004417291 RP004447089 RP004461774 RP004487873 RP004520444 RP004523621 RP004526251
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005640 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38433
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Eip63E CG10579 (Li, 1999.11)
Source for database merge of	Source for merge of: Eip63E Pftaire (Munroe et al., 1998.5.12)
Additional comments
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in mitotic index is seen. (Bettencourt-Dias et al., 2004) Eip63E is required not only for metamorphosis, but also maternally and for embryonic and larval development. (Stowers et al., 2000) Characterisation of Eip63E. (Sauer et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079180 NM_168033 NM_168034 NM_168035 NM_168036 NM_001043116 NM_001043117 NM_001043118 NM_001043119 NM_001043120 NM_001043121 NM_001169869 NM_001202113 NM_001274444 RefSeq (Proteins) • NP_523904 NP_728888 NP_728889 NP_728890 NP_728891 NP_001036581 NP_001036582 NP_001036583 NP_001036584 NP_001036585 NP_001036586 NP_001163340 NP_001189042 NP_001261373 DDBJ / EMBL / GenBank • AA440316 AA949110 AAD45509 AAD45510 AAD45511 AAD45512 AAD45513 AAD45514 AAD45515 AAD45516 AAD45517 AAF47781 AAG22238 AAG22239 AAM29372 AAN11568 AAN11569 AAQ20873 AAQ22533 ABI31232 ABI31233 ABI31234 ABI31235 ABI31236 ABI31237 ACZ94612 ADV37479 AF152398 AF152399 AF152400 AF152401 AF152402 AF152403 AF152404 AF152405 AF152406 AGB94068 AW942344 AY113367 AY310908 BT010064 CAA67862 CL844437 CL943534 CZ466821 CZ466822 CZ467682 CZ467683 CZ473100 CZ475719 CZ476773 CZ477926 CZ477927 CZ478837 CZ479153 CZ480911 CZ487809 X99512 Entrez Gene - A searchable database of RefSeq genes. • 38433 UniProtKB/TrEMBL • Q7KM03 Q7KM04 Q7KM05 Q7KM08 Q7YUC0 Q8MZ44 Q9XTK9 Q94888
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b5, heme-binding site (IPR018506) Protein kinase, catalytic domain (IPR000719) Serine/threonine- / dual specificity protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00122
Linkouts
	BioGRID - A database of protein and genetic interactions • 63926 DroID - A comprehensive database of gene and protein interactions. • FBgn0005640 DRSC - Results from RNAi screens. • FBgn0005640 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005640 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10038-RB;CG10579-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005640 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38433 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/eip63e1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38433 modMine - Data generated by the modENCODE project. • FBgn0005640 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7KM03
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	cdc2-63E (Richardson, 2005.2.11, Brumby et al., 2004) CG10579 (Morrison et al., 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2010.12.1, Ni et al., 2011.7.19) Eip63E (Liu and Finley, 2007, Daneshvar et al., 2013, Buszczak et al., 2007, Hueber et al., 2007, Liu and Finley, 2008, Turner et al., 2011, FlyBase Curators, 2008, Jungreis et al., 2011, Jemc and Rebay, 2007, Davidson et al., 2009, Godfrey et al., 2006, Bushati et al., 2008, Liu and Finley, 2010, Japanese National Institute of Genetics, 2012.5.21) EIP63E (Ritter and Beckstead, 2010) L63 (Rascle et al., 2003, Stowers et al., 2000, Rascle and Hogness, 1999, Munroe et al., 1998.5.12, Davidson et al., 2009) PFTAIRE (Bjorklund et al., 2006)
Name Synonym	Ecdysone-induced protein 63E (Hueber et al., 2007) Pftaire (Liu and Kipreos, 2000, ) PFTAIRE (Morrison et al., 2000, Lehner, 1996.7.23, Sauer et al., 1996, )
Secondary FlyBase IDs
	FBgn0016695 FBgn0024942
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 23 ) Abstract  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 3 )
	Daneshvar et al., 2013, Biol. Open 2(1): 1--9 MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. [FBrf0220584] Fabian et al., 2012, Mol. Ecol. 21(19): 4748--4769 Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America. [FBrf0219505] Turner et al., 2011, PLoS Genet. 7(3): e1001336 Population-Based Resequencing of Experimentally Evolved Populations Reveals the Genetic Basis of Body Size Variation in Drosophila melanogaster. [FBrf0213327] Show all research papers ...