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Gene Dmel\wdn

General Information
Symbol	Dmel\wdn	Species	D. melanogaster
Name	wings down	Annotation symbol	CG1454
Feature type	protein_coding_gene	FlyBase ID	FBgn0005642
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	pqp
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98E5-98E5	Sequence location	3R:24,633,705..24,637,049 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wings down is referred to in FlyBase by the symbol Dmel\wdn (CG1454, FBgn0005642). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. It is reported to be involved in the biological process: regulation of transcription, DNA-dependent. 11 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1635761_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of wdn. Gene sequence location is 3R:24633705..24637049.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Sryc: Serendipity cognate Structural gene for a protein of 868 amino acids with eight TFIIIA-like fingers. Developmental Northern blots reveal abundant transcript in adult females but not males and during the first four hours of embryonic development; low levels present in later embryos, larvae, and pupae. In situ hybridization to tissue sections shows that transcripts produced in nurse cells and beginning at stage 10 are transported to and accumulate in oocytes. *wdn: wings down Wings extended and drooping or even directed ventrally, broad with close crossveins. Overlaps wild type. Low viability. RK3.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN25208 HFA17095
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98E5-98E5   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98E3-98E4   (determined by in situ hybridisation)   (Ranz et al., 2001) 98E-98F   (determined by in situ hybridisation)   (Vincent et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\wdn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wdn-RA FBtr0085356  NM_057552   3174   869
Additional Transcript Data & Comments
Reported size (kB)	3.2 (northern blot) (Vincent et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wdn-PA   FBpp0084725   95.3   869   8.63     NP_476900   AAF56815
Additional Polypeptide Data & Comments
Reported size (kDa)	868 (aa); 96 (kD predicted) (Vincent et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202494   AA391195   AA439102   AA439508   AA536391   AA538574   AA538591   AA816743   AA950721   AA979168   AE014297 AAF56815   AC006170   AI386644   AI402338   AI517852   AI519215   AI520617   AI546729   AW943537   AY058690 AAL13919   AY231836   BG638922   BI163807   BI212704   BI234323   BI631670   BI635952   BQ103685   CL528254   CL610232   CO265245   CO265593   CO293818   CO295219   CO297026   CO298097   CO310571   CO331295   CO337588   CO340480   CO340989   EC052850   EC054819   EC061371   EC084276   EC212977   EC224863   EC247244   EC248015   EC260331   EC266133   EL871130   EL871247   EL871367   EL871368   EL871481   M23391 AAA28487
UniProtKB/Swiss-Prot	P15619
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References enhancer FBsf0000161144 3R:24,637,090..24,637,340 comment=region necessary for wdn expression. evidence=experimental (Segalat et al., 1992) enhancer FBsf0000161145 3R:24,637,100..24,637,270 comment=region promotes expression in follicle cells. evidence=experimental (Segalat et al., 1994) enhancer FBsf0000161143 3R:24,637,031..24,637,140 comment=region promotes expression in the germ line. evidence=experimental (Segalat et al., 1994)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Vincent et al., 1988) embryonic stage -- adult stage     (Vincent et al., 1988) adult stage & oogenesis   oocyte   (Vincent et al., 1988) nurse cell   (Vincent et al., 1988)
Additional Descriptive Data
	wdn transcripts are most abundant in early embryos and virgin females on northern blots but are detected in all stages tested. They are detected by in situ hybridization in nurse cells up to stage S10A and then are transferred to the oocyte. Transcript levels decline after egg deposition and before the cellular blastoderm stage. Transcripts are uniformly distributed during gastrulation but not at later stages. (Vincent et al., 1988)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage     (Segalat et al., 1992) adult stageoogenesis stage S1 -- S6   nurse cell   (Segalat et al., 1992) adult stageoogenesis stage S9 -- S10   nurse cell   (Segalat et al., 1992) adult stageoogenesis stage S7 -- S14   oocyte   (Segalat et al., 1992)
Additional Descriptive Data
	nucleus (Segalat et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0005642    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0005642 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0005642 expression level Developmental Stage   Expression Level embryo 00-02hr    7117 embryo 02-04hr    4548 embryo 04-06hr    3592 embryo 06-08hr    4023 embryo 08-10hr    3868 embryo 10-12hr    2943 embryo 12-14hr    2088 embryo 14-16hr    2135 embryo 16-18hr    1561 embryo 18-20hr    931 embryo 20-22hr    2217 embryo 22-24hr    1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day    1625 adult female 05day    2874 adult female 30day    3136 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7117) embryo 02-04hr  (4548) embryo 04-06hr  (3592) embryo 06-08hr  (4023) embryo 08-10hr  (3868) embryo 10-12hr  (2943) embryo 12-14hr  (2088) embryo 14-16hr  (2135) embryo 16-18hr  (1561) embryo 18-20hr  (931) embryo 20-22hr  (2217) embryo 22-24hr  (1748) larva L1  (908) larva L2  (551) larva L3 12hr old  (486) larva L3 puffstage 1-2  (514) larva L3 puffstage 3-6  (755) larva L3 puffstage 7-9  (772) white prepupae new  (826) white prepupae 12hr  (1149) white prepupae 24hr  (1271) pupae 2d postWPP  (683) pupae 3d postWPP  (385) pupae 4d postWPP  (401) adult male 01day  (513) adult male 05day  (772) adult male 30day  (836) adult female 01day  (1625) adult female 05day  (2874) adult female 30day  (3136) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7117) embryo 02-04hr  (4548) embryo 04-06hr  (3592) embryo 06-08hr  (4023) embryo 08-10hr  (3868) embryo 10-12hr  (2943) embryo 12-14hr  (2088) embryo 14-16hr  (2135) embryo 16-18hr  (1561) embryo 18-20hr    931 embryo 20-22hr  (2217) embryo 22-24hr  (1748) larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day  (1625) adult female 05day  (2874) adult female 30day  (3136) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7117 embryo 02-04hr    4548 embryo 04-06hr    3592 embryo 06-08hr    4023 embryo 08-10hr    3868 embryo 10-12hr    2943 embryo 12-14hr    2088 embryo 14-16hr    2135 embryo 16-18hr    1561 embryo 18-20hr    931 embryo 20-22hr    2217 embryo 22-24hr    1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day    1625 adult female 05day    2874 adult female 30day    3136 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7117 embryo 02-04hr    4548 embryo 04-06hr    3592 embryo 06-08hr    4023 embryo 08-10hr    3868 embryo 10-12hr    2943 embryo 12-14hr    2088 embryo 14-16hr    2135 embryo 16-18hr    1561 embryo 18-20hr    931 embryo 20-22hr    2217 embryo 22-24hr    1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day    1625 adult female 05day    2874 adult female 30day    3136 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0005642 expression level Developmental Stage   Expression Level embryo 00-02hr    7117 embryo 02-04hr    4548 embryo 04-06hr    3592 embryo 06-08hr    4023 embryo 08-10hr    3868 embryo 10-12hr    2943 embryo 12-14hr    2088 embryo 14-16hr    2135 embryo 16-18hr    1561 embryo 18-20hr    931 embryo 20-22hr    2217 embryo 22-24hr    1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day    1625 adult female 05day    2874 adult female 30day    3136 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (7117) embryo 02-04hr  (4548) embryo 04-06hr  (3592) embryo 06-08hr  (4023) embryo 08-10hr  (3868) embryo 10-12hr  (2943) embryo 12-14hr  (2088) embryo 14-16hr  (2135) embryo 16-18hr  (1561) embryo 18-20hr  (931) embryo 20-22hr  (2217) embryo 22-24hr  (1748) larva L1  (908) larva L2  (551) larva L3 12hr old  (486) larva L3 puffstage 1-2  (514) larva L3 puffstage 3-6  (755) larva L3 puffstage 7-9  (772) white prepupae new  (826) white prepupae 12hr  (1149) white prepupae 24hr  (1271) pupae 2d postWPP  (683) pupae 3d postWPP  (385) pupae 4d postWPP  (401) adult male 01day  (513) adult male 05day  (772) adult male 30day  (836) adult female 01day  (1625) adult female 05day  (2874) adult female 30day  (3136) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (7117) embryo 02-04hr  (4548) embryo 04-06hr  (3592) embryo 06-08hr  (4023) embryo 08-10hr  (3868) embryo 10-12hr  (2943) embryo 12-14hr  2088 embryo 14-16hr  2135 embryo 16-18hr  1561 embryo 18-20hr    931 embryo 20-22hr  2217 embryo 22-24hr  1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day  1625 adult female 05day  (2874) adult female 30day  (3136) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    7117 embryo 02-04hr    4548 embryo 04-06hr    3592 embryo 06-08hr    4023 embryo 08-10hr    3868 embryo 10-12hr    2943 embryo 12-14hr    2088 embryo 14-16hr    2135 embryo 16-18hr    1561 embryo 18-20hr    931 embryo 20-22hr    2217 embryo 22-24hr    1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day    1625 adult female 05day    2874 adult female 30day    3136 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    7117 embryo 02-04hr    4548 embryo 04-06hr    3592 embryo 06-08hr    4023 embryo 08-10hr    3868 embryo 10-12hr    2943 embryo 12-14hr    2088 embryo 14-16hr    2135 embryo 16-18hr    1561 embryo 18-20hr    931 embryo 20-22hr    2217 embryo 22-24hr    1748 larva L1    908 larva L2    551 larva L3 12hr old    486 larva L3 puffstage 1-2    514 larva L3 puffstage 3-6    755 larva L3 puffstage 7-9    772 white prepupae new    826 white prepupae 12hr    1149 white prepupae 24hr    1271 pupae 2d postWPP    683 pupae 3d postWPP    385 pupae 4d postWPP    401 adult male 01day    513 adult male 05day    772 adult male 30day    836 adult female 01day    1625 adult female 05day    2874 adult female 30day    3136 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0005642    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0005642 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0005642 expression level Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0005642 expression level Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    182.175 Larval Midgut    51 Larval Hindgut    56.7 Larval Malpighian Tubules    55.4 Larval Fat Body    52.5 Larval Salivary Gland    132.3 Larval Trachea    105.45 Larval Carcass    58.35 Adult Head    52.7 Adult Eye    66.475 Adult Brain    114.3 Adult Thoracic-Abdominal Ganglion    68.2 Adult Crop    74.3 Adult Midgut    67.7 Adult Hindgut    68.1 Adult Malpighian Tubules    72.1 Adult Fat Body    49.6 Adult Salivary Gland    124.1 Adult Heart    51.25 Adult VirginFemale Spermatheca    72.3 Adult InseminatedFemale Spermatheca    73.6 Adult Ovary    444.4 Adult Testis    75.1 Adult Male Accessory Gland    80.4 Adult Carcass    66.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    52.7   NA  Eye    66.475   NA  Brain    114.3   182.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    68.2   NA  Crop    74.3   51  Midgut    67.7   56.7  Hindgut    68.1   55.4  Malpighian Tubules    72.1   52.5  Fat Body    49.6   132.3  Salivary Gland    124.1   NA  Heart    51.25   105.45  Trachea    NA   NA  VirginFemale Spermatheca    72.3   NA  InseminatedFemale Spermatheca    73.6   NA  Ovary    444.4   NA  Testis    75.1   NA  Male Accessory Gland    80.4   58.35  Carcass    66.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005642 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1454-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for wdn Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect | recessive wdn48 wdn181 lethal | larval stage | maternal effect | recessive wdn48 wdn181 viable wdnEY09072 viable, with Scer\GAL4pnr-MD237 wdnGD1561 Sterility Allele fertile wdnEY09072 Other Phenotypes Allele visible | recessive wdn48 wdn181 wild-type wdn+t6.1 Phenotype manifest in Allele anterior crossvein | maternal effect wdn181 wdn48 dorsocentral bristle | maternal effect wdn181 wdn48 postalar bristle | maternal effect wdn181 wdn48 posterior crossvein | maternal effect wdn181 wdn48 scutellar bristle | maternal effect wdn181 wdn48 wing | maternal effect wdn181 wdn48
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of wdn Class Mutagen Stocks Known lesion wdnEY09072 P-element activity 1 -- wdnKG09418 P-element activity 1 -- wdn181 Delta2-3 0 Yes wdn1 0 -- wdn48 Delta2-3 0 Yes wdnunspecified 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wdn Class Mutagen Stocks Known lesion wdnGD1561 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wdnGLV21019 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wdnKK104248 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wdn+t6.1 in vitro construct - genomic fragment 0 Yes wdnt5.8 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6210 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{wdn-lacZ.AL} No P{wdn-lacZ.AX} No P{wdn-lacZ.BQ} No P{wdn-lacZ.CL} No P{wdn-lacZ.CW2} No P{wdn-lacZ.CX} No P{wdn-lacZ.DK} No P{wdn-lacZ.DN} No P{wdn-lacZ.DP} No P{wdn-lacZ.DR} No P{wdn-lacZ.DX} No P{wdn-lacZ.HN} No P{wdn-lacZ.HP} No P{wdn-lacZ.HX} No P{wdn-lacZ.JX} No P{wdn-lacZ.LX} No P{wdn-lacZ.NH} No P{wdn-lacZ.PH} No UAS construct P{GD1561} NA P{KK104248} NA P{TRiP.GLV21019} NA characterization construct P{mutatedSalI-SalI} NA P{SalI-SalI} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}CG1646317 NA P{}CG1646407 NA P{SUPor-P}wdnKG09418 NA insertion of mobile activating element P{EPgy2}wdnEY09072 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (assigned by UniProtKB) (Segalat et al., 1992)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent non-traceable author statement (Swiss-Prot Project Members, 1990.4.1)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:U27186 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.4.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wdn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68274 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005642 DroID - A comprehensive database of gene and protein interactions. • FBgn0005642 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43398
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16427 Dere\GG12054 Dgri\GH18105 Dmoj\GI10527 Dper\GL13688 Dpse\GA13064 Dsec\GM12283 Dsim\GD18017 Dvir\GJ24179 Dwil\GK10984 Dyak\wdn
Curated drosophilid orthologs	Dpse\GA13064   Drep\wdn (Ranz et al., 2001, Ranz et al., 2001) Dyak\wdn
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • ENSCPOP00000010666 Cavia porcellus (guinea pig) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0067919 FBgn0212995 FBgn0211263 FBgn0189562 FBgn0167220 FBgn0073102 FBgn0151293 FBgn0133291 FBgn0104346 FBgn0093448 CPIJ002705 BGIBMGA013636 AGAP001555 AAEL004869 GLEAN_00840
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	35654 y1 sc* v1; P{TRiP.GLV21019}attP2 19766 y1 w67c23; P{EPgy2}wdnEY09072/TM3, Sb1 Ser1 16483 y1; ry506 P{SUPor-P}wdnKG09418/TM3, Sb1 Ser1
VDRC	v106451 P{KK104248}VIE-260B v37096 w1118; P{GD1561}v37096/CyO
Genomic Clones ( 1 )
	BACR48K07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 49 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD40824
Other clones	DPiM_LD40824 yak-em_wdn
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16783 GH21523 LD02173 LD05129 LD09295 LD13564 LD14095 LD16985 LD18136 LD18156 LD30823 LD33455 LD42950 RE03318 RE17847 RE30013 RH61292 SD10751 SD17501
Other clones	32451 32739 74826 79365 82183 99472 297899 EC052850 EC054819 EC260331 EK142021 EK143155 EK171505 EK204923 EK208936 EK215749 EK222031 EK299023 EN14852 EP10730 EP11701 IP03276 IP03376 IP03476 IP03576 LD38729 UUGC1096
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005642 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43398
Antibody Information
	polyclonal (Segalat et al., 1992)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: wdn CG1454 (Liang, 1999.11)
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Functional dissection of the promoter using Ecol\lacZ reporter constructs identifies the minimal promoter sequences between position -210 and +30, relative to the transcription start site. These sequences subdivide into follicle cell- and germ line specific regions and appear to function in a direction-independent and distance-sensitive manner. (Segalat et al., 1994) wdn protein expression has been analysed. (Segalat et al., 1992) wdn zinc finger protein product is present in the oocyte nucleus and during embryonic and larval development. Homozygous mutants are zygotic lethal and display a disorganization of the bodyplan. (Segalat and Lepesant, 1991) Structural gene for a protein of 868 amino acids with eight TFIIIA-like fingers. Developmental Northern blots reveal abundant transcript in adult females but not males and during the first four hours of embryonic development; low levels present in later embryos, larvae and pupae. In situ hybridization to tissue sections shows that transcripts produced in nurse cells and beginning at stage 10 are transported to and accumulate in oocytes.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057552 RefSeq (Proteins) • NP_476900 DDBJ / EMBL / GenBank • AAA28487 AAF56815 AAL13919 AC006170 AI520617 AW943537 AY058690 CL528254 CL610232 M23391 Entrez Gene - A searchable database of RefSeq genes. • 43398 UniProtKB/Swiss-Prot • P15619
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68274 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005642 DroID - A comprehensive database of gene and protein interactions. • FBgn0005642 DRSC - Results from RNAi screens. • FBgn0005642 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005642 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1454-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005642 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43398 InParanoid A subset of ortholog calls from InParanoid. • ENSCPOP00000010666 Cavia porcellus (guinea pig) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43398 modMine - Data generated by the modENCODE project. • FBgn0005642 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0067919 FBgn0212995 FBgn0211263 FBgn0189562 FBgn0167220 FBgn0073102 FBgn0151293 FBgn0133291 FBgn0104346 FBgn0093448 CPIJ002705 BGIBMGA013636 AGAP001555 AAEL004869 GLEAN_00840 REDfly - A database of transcriptional regulatory elements. • FBgn0005642
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG1454 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19) pqp (Segalat et al., 1994, Segalat and Lepesant, 1991, Segalat et al., 1992, ) sry-c   Sryc   sry-h1 (Mahajan-Miklos and Cooley, 1994, ) sry h-l (Vincent, 1993.8.17) wdn
Name Synonym	pourquoi-pas   pourquoi-pas? (Segalat et al., 1994) serendipity-cognate   Serendipity cognate   wings down
Secondary FlyBase IDs
	FBgn0003509 FBgn0004006 FBgn0004365
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...