lat, latheo, l(2)49Fd, ORC, DmORC3
Gene model reviewed during 5.44
gene_with_dicistronic_mRNA ; SO:0000722
Gene model reviewed during 5.46
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Orc3 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Orc3 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Orc3 lat
Source for merge of: lat Orc3
Renamed from 'lat' to 'Orc3' to be consistent with the nomenclature for the other 5 genes encoding subunits of the 'origin recognition complex' in D. melanogaster and the established nomenclature for these conserved genes across species. 'lat'/'latheo' are retained as synonyms for the gene.
Cessation of cell proliferation in third instar larvae defines the phenotypic defect of null mutations in the lat gene.
The lat gene product plays a central role in regulating Ca2+- and activity-dependent synaptic plasticity.
Basal synaptic transmission amplitude at the lat mutant NMJ is elevated 3 to 4 fold, and Ca2+ dependence of transmission is significantly reduced. Multiple forms of synaptic facilitation and posttetanic potentiation are strongly depressed or absent at the mutant synapse.
Genetic dissection of the learning and memory gene lat.
lat is involved in the middle term component of memory formation (MTM).
'latheo' is Greek for "to cause a person not to know".
Named after a Greek word, meaning "forgetful", related to the name of one of the rivers of Hades, Lethe, whose waters caused all those who drank from them to forget their former life.
"latheo" is Greek: "to cause a person not to know" (Benet's Reader's Encyclopedia 1987).