A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\lat

General Information
SymbolDmel\latSpeciesD. melanogaster
NamelatheoAnnotation symbolCG4088
Feature typeprotein_coding_geneFlyBase IDFBgn0005654
Gene Model StatusCurrent Stock availability 10 publicly available
Also Known AsORC3, ORC, DmORC3, vr6, l(2)49Fd
Genomic Location
Chromosome (arm)2RRecombination map
Cytogenetic map49F7-49F8Sequence location2R:9,090,248..9,094,027 [-]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene latheo is referred to in FlyBase by the symbol Dmel\lat (CG4088, FBgn0005654). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: centrosome organization; DNA-dependent DNA replication initiation; centrosome duplication. 38 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; bouton; axon terminus; imaginal disc; embryonic/larval central nervous system. It has one annotated transcript and one annotated polypeptide. Protein features are: Origin recognition complex, subunit 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627828_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of lat expression signal. See the GBrowse view of lat to determine the overlapping gene(s). Gene sequence location is 2R:9090248..9094027.

External Summaries
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
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FB2011_10
References
FB2012_01
Controlled Vocabulary Terms
References
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
49F7-49F8  
Limits computationally determined from genome sequence between P{EP}CG33182EP728&P{lacW}Aats-valk14804 and P{EP}DpEP358  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
49F-49F  
(determined by in situ hybridisation)  
49F7-49F8  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\lat for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0087734 FBtr0087735 FBtr0087768 FBtr0300287 FBtr0087737 FBtr0087736 FBpp0086848 FBpp0086847 FBpp0086881 FBpp0289515 FBpp0086850 FBpp0086849 FBti0009081 FBti0007780 FBti0026413 FBti0125151_1 FBti0125151_2 FBti0071182
Comments on Gene Model
gene_with_dicistronic_mRNA ; SO:0000722
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0087768
  3275
  721
Additional Transcript Data & Comments
Reported size (kB)
3.9, 2.6 (northern blot)
2.3 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
lat-PA  
FBpp0086881  
82.3  
721  
7.40  
Additional Polypeptide Data & Comments
Reported size (kDa)
721 (aa); 79 (kD observed)
Comments
lat protein was isolated from purified ORC (origin recognition complex) from 0-12hr embryos. The six-subunit ORC can be reconstituted with recombinant proteins into a complex that restores DNA replication in ORC-depleted Drosophila or Xenopus extracts.
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
lat message is detected in the adult brain.
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
lat protein is widely distributed in the adult brain, with higher levels in the central brain.
lat protein is detected in all subtypes of synaptic boutons at larval neuromuscular junctions. Colocalization with the presynaptic-vesicle associated Csp protein indicates that lat protein is restricted to the presynaptic compartment.
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view Aats-val-RB Aats-val-RA lat-RA CG34315-RB FLASH-RB FLASH-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0005654


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0005654
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0005654 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 
 2035
pupae 2d postWPP
 
 1889
pupae 3d postWPP
 
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 
 1822
adult male 05day
 
 3123
adult male 30day
 
 2661
adult female 01day
 
 592
adult female 05day
 
 1409
adult female 30day
 
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (2316)
embryo 02-04hr
 (686)
embryo 04-06hr
 (1809)
embryo 06-08hr
 (965)
embryo 08-10hr
 (663)
embryo 10-12hr
 (373)
embryo 12-14hr
 (185)
embryo 14-16hr
 (146)
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 (210)
larva L2
 (244)
larva L3 12hr old
 (148)
larva L3 puffstage 1-2
 (309)
larva L3 puffstage 3-6
 (591)
larva L3 puffstage 7-9
 (764)
white prepupae new
 (701)
white prepupae 12hr
 (1370)
white prepupae 24hr
 (2035)
pupae 2d postWPP
 (1889)
pupae 3d postWPP
 (1455)
pupae 4d postWPP
 (1158)
adult male 01day
 (1822)
adult male 05day
 (3123)
adult male 30day
 (2661)
adult female 01day
 (592)
adult female 05day
 (1409)
adult female 30day
 (1491)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (2316)
embryo 02-04hr
 
 686
embryo 04-06hr
 (1809)
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 (2035)
pupae 2d postWPP
 (1889)
pupae 3d postWPP
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 (1822)
adult male 05day
 (3123)
adult male 30day
 (2661)
adult female 01day
 
 592
adult female 05day
 1409
adult female 30day
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 
 2035
pupae 2d postWPP
 
 1889
pupae 3d postWPP
 
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 
 1822
adult male 05day
 
 3123
adult male 30day
 
 2661
adult female 01day
 
 592
adult female 05day
 
 1409
adult female 30day
 
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 
 2035
pupae 2d postWPP
 
 1889
pupae 3d postWPP
 
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 
 1822
adult male 05day
 
 3123
adult male 30day
 
 2661
adult female 01day
 
 592
adult female 05day
 
 1409
adult female 30day
 
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0005654 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 
 2035
pupae 2d postWPP
 
 1889
pupae 3d postWPP
 
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 
 1822
adult male 05day
 
 3123
adult male 30day
 
 2661
adult female 01day
 
 592
adult female 05day
 
 1409
adult female 30day
 
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (2316)
embryo 02-04hr
 (686)
embryo 04-06hr
 (1809)
embryo 06-08hr
 (965)
embryo 08-10hr
 (663)
embryo 10-12hr
 (373)
embryo 12-14hr
 (185)
embryo 14-16hr
 (146)
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 (210)
larva L2
 (244)
larva L3 12hr old
 (148)
larva L3 puffstage 1-2
 (309)
larva L3 puffstage 3-6
 (591)
larva L3 puffstage 7-9
 (764)
white prepupae new
 (701)
white prepupae 12hr
 (1370)
white prepupae 24hr
 (2035)
pupae 2d postWPP
 (1889)
pupae 3d postWPP
 (1455)
pupae 4d postWPP
 (1158)
adult male 01day
 (1822)
adult male 05day
 (3123)
adult male 30day
 (2661)
adult female 01day
 (592)
adult female 05day
 (1409)
adult female 30day
 (1491)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 2035
pupae 2d postWPP
 1889
pupae 3d postWPP
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 1822
adult male 05day
 (3123)
adult male 30day
 (2661)
adult female 01day
 
 592
adult female 05day
 1409
adult female 30day
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 
 2035
pupae 2d postWPP
 
 1889
pupae 3d postWPP
 
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 
 1822
adult male 05day
 
 3123
adult male 30day
 
 2661
adult female 01day
 
 592
adult female 05day
 
 1409
adult female 30day
 
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 2316
embryo 02-04hr
 
 686
embryo 04-06hr
 
 1809
embryo 06-08hr
 
 965
embryo 08-10hr
 
 663
embryo 10-12hr
 
 373
embryo 12-14hr
 
 185
embryo 14-16hr
 
 146
embryo 16-18hr
 
 97
embryo 18-20hr
 
 57
embryo 20-22hr
 
 40
embryo 22-24hr
 
 51
larva L1
 
 210
larva L2
 
 244
larva L3 12hr old
 
 148
larva L3 puffstage 1-2
 
 309
larva L3 puffstage 3-6
 
 591
larva L3 puffstage 7-9
 
 764
white prepupae new
 
 701
white prepupae 12hr
 
 1370
white prepupae 24hr
 
 2035
pupae 2d postWPP
 
 1889
pupae 3d postWPP
 
 1455
pupae 4d postWPP
 
 1158
adult male 01day
 
 1822
adult male 05day
 
 3123
adult male 30day
 
 2661
adult female 01day
 
 592
adult female 05day
 
 1409
adult female 30day
 
 1491
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0005654


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0005654
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0005654 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0005654 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 74
Larval Midgut
 
 6.7
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 19.175
Larval Carcass
 
 19.65
Adult Head
 
 9
Adult Eye
 
 8.475
Adult Brain
 
 9.9
Adult Thoracic-Abdominal Ganglion
 
 9.7
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 5
Adult Malpighian Tubules
 
 6.4
Adult Fat Body
 
 3.5
Adult Salivary Gland
 
 9.5
Adult Heart
 
 3.275
Adult VirginFemale Spermatheca
 
 4.2
Adult InseminatedFemale Spermatheca
 
 4.2
Adult Ovary
 
 198.6
Adult Testis
 
 434.7
Adult Male Accessory Gland no informative data
Adult Carcass
 
 8.2
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland no informative data
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 9
 
NA 
Eye
 
 8.475
 
NA 
Brain
 
 9.9
 
74 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 9.7
 
NA 
Crop
 
 no informative data
 
6.7 
Midgut
 
 no informative data
 
no informative data 
Hindgut
 
 5
 
no informative data 
Malpighian Tubules
 
 6.4
 
no informative data 
Fat Body
 
 3.5
 
no informative data 
Salivary Gland
 
 9.5
 
NA 
Heart
 
 3.275
 
19.175 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 4.2
 
NA 
InseminatedFemale Spermatheca
 
 4.2
 
NA 
Ovary
 
 198.6
 
NA 
Testis
 
 434.7
 
NA 
Male Accessory Gland
 
 no informative data
 
19.65 
Carcass
 
 8.2

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 34 )
For All Classical Alleles Show

Allele of latClassMutagenStocksKnown lesion
lat13 --
lat63 Yes
latEP11681 --
lat20 --
lat30 --
lat40 --
lat50 --
lat70 --
latE11hypomorphic allele - genetic evidence0 Yes
latE12hypomorphic allele - genetic evidence0 Yes
latE13hypomorphic allele - genetic evidence0 Yes
latE14hypomorphic allele - genetic evidence0 Yes
latE16ahypomorphic allele - genetic evidence0 Yes
latE16bhypomorphic allele - genetic evidence0 Yes
latE17hypomorphic allele - genetic evidence0 Yes
latE1hypomorphic allele - genetic evidence0 Yes
latE4hypomorphic allele - genetic evidence0 Yes
latE5hypomorphic allele - genetic evidence0 Yes
latE6hypomorphic allele - genetic evidence0 Yes
latE8hypomorphic allele - genetic evidence0 Yes
latE9hypomorphic allele - genetic evidence0 Yes
latle1070 --
latlE3110 Yes
latlE344loss of function allele0 Yes
latlE340 Yes
latlE3520 Yes
latlE3570 Yes
latlE3720 Yes
latlE49loss of function allele0 Yes
latP1hypomorphic allele - genetic evidence0 Yes
latP20 --
latP0 --
latvr6.350 Yes
latvr6.6loss of function allele0 Yes
hide Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show

Allele of latClassMutagenStocksKnown lesion
latGD12721 Yes
latJF019151 Yes
latKK1008941 Yes
lat+t17.10 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
characterization construct
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
insertion of enhancer trap
hide Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
hide Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component
CV term
References
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term
References
inferred from electronic annotation with InterPro:IPR020795
non-traceable author statement
Biological Process
CV term
References
non-traceable author statement
non-traceable author statement
non-traceable author statement
non-traceable author statement
traceable author statement
Cellular Component
CV term
References
inferred from sequence or structural similarity with EMBL:AF125507
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
lat allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 10 )
Bloomington
Kyoto
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 27 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
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hide Etymology
'latheo' is Greek for "to cause a person not to know".
"latheo" is Greek: "to cause a person not to know" (Benet's Reader's Encyclopedia 1987).
Named after a Greek word, meaning "forgetful", related to the name of one of the rivers of Hades, Lethe, whose waters caused all those who drank from them to forget their former life.
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: lat Orc3
Additional comments
One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by lat (CG4088) and CG34315 (CG34315).
hide Other Comments
The lat gene product functions in DNA replication during cell proliferation.
Cessation of cell proliferation in third instar larvae defines the phenotypic defect of null mutations in the lat gene.
The lat gene product is specifically localised to the synaptic boutons.
The lat gene product plays a central role in regulating Ca2+- and activity-dependent synaptic plasticity.
Basal synaptic transmission amplitude at the lat mutant NMJ is elevated 3 to 4 fold, and Ca2+ dependence of transmission is significantly reduced. Multiple forms of synaptic facilitation and posttetanic potentiation are strongly depressed or absent at the mutant synapse.
Genetic dissection of the learning and memory gene lat.
lat is involved in the middle term component of memory formation (MTM).
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
GO
  • GO:5664
  • GO:6270
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym
l(2)vr6
 
Name Synonym
Origin recognition complex subunit 3
Secondary FlyBase IDs
  • FBgn0002075
  • FBgn0004955
  • FBgn0023182
hide References ( 84 )
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hide Recent research papers ( 2 )
Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Müller et al., 2010, EMBO J. 29(19): 3344--3357
Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030]
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All reviews listed in FlyBase were published before 2010