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Gene Dmel\lat

General Information
Symbol	Dmel\lat	Species	D. melanogaster
Name	latheo	Annotation symbol	CG4088
Feature type	protein_coding_gene	FlyBase ID	FBgn0005654
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	ORC3, ORC, DmORC3, vr6, l(2)49Fd
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49F7-49F8	Sequence location	2R:9,090,233..9,094,027 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene latheo is referred to in FlyBase by the symbol Dmel\lat (CG4088, FBgn0005654). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: centrosome organization; DNA replication initiation; border follicle cell migration; centrosome duplication. 40 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; bouton; axon terminus; imaginal disc; embryonic/larval central nervous system. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Origin recognition complex, subunit 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627828_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of lat expression signal. See the GBrowse view of lat to determine the overlapping gene(s). Gene sequence location is 2R:9090233..9094027.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49F7-49F8   Limits computationally determined from genome sequence between P{EP}CG33182EP728&P{lacW}Aats-valk14804 and P{EP}DpEP358
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49F-49F   (determined by in situ hybridisation)   (Pinto et al., 1999) 49F7-49F8   (determined by in situ hybridisation)   (Chesnokov et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\lat for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Gene model reviewed during 5.46 gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) lat-RA FBtr0087768  NM_057556   3290   721 lat-RB FBtr0087769  NM_165971   2423   721
Additional Transcript Data & Comments
Reported size (kB)	3.9, 2.6 (northern blot) (Pinto et al., 1999) 2.3 (northern blot) (Chesnokov et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein lat-PA   FBpp0086881   82.3   721   7.40     NP_476904   AAF58411 lat-PB   FBpp0086882   82.3   721   7.40     NP_725260   AAM68599
Additional Polypeptide Data & Comments
Reported size (kDa)	721 (aa); 79 (kD observed) (Pinto et al., 1999, Chesnokov et al., 1999)
Comments	lat protein was isolated from purified ORC (origin recognition complex) from 0-12hr embryos. The six-subunit ORC can be reconstituted with recombinant proteins into a complex that restores DNA replication in ORC-depleted Drosophila or Xenopus extracts. (Chesnokov et al., 1999)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Origin recognition complex, subunit 3 (IPR020795)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA821131   AE013599 AAF58411   AE013599 AAM68599   AC005655   AF139062 AAD39472   AF152093 AAD32712   AF153209 AAD47349   AI389631   AI405403   AI517734   AI519920   AQ254825   AW941102   AY060817 AAL28365   BE975254   BE978224   BF487287   BF488251   BG637627   BG639162   BI161978   BI161979   BI241871   BI615901   BT125572   BT132766   CK657184   CK658103   CO273351   CO300349   CO309509   CO309677   CO330892   DQ017454 AAY82232   DQ017455 AAY82233   EC060459   EC073920   EC201945   EC239481   EC245811
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K2L1 Q9TVK9 Q9Y1B4 Q3YNA4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   adult brain   (Pinto et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage     (Chesnokov et al., 1999)
Additional Descriptive Data
	lat message is detected in the adult brain. (Pinto et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   neuromuscular junction   (Rohrbough et al., 1999) bouton   (Rohrbough et al., 1999) western blot Stage Tissue/Position (including subcellular localization) Reference third instar larval stage     (Pinto et al., 1999) adult stage   adult brain   (Pinto et al., 1999)
Additional Descriptive Data
	lat protein is widely distributed in the adult brain, with higher levels in the central brain. (Pinto et al., 1999) lat protein is detected in all subtypes of synaptic boutons at larval neuromuscular junctions. Colocalization with the presynaptic-vesicle associated Csp protein indicates that lat protein is restricted to the presynaptic compartment. (Rohrbough et al., 1999)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
mitotic spindle inferred from direct assay (Müller et al., 2010) nuclear origin of replication recognition complex inferred from direct assay (Chesnokov et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74 Larval Midgut    6.7 Larval Hindgut    11.4 Larval Malpighian Tubules    11.3 Larval Fat Body    64.2 Larval Salivary Gland    14.1 Larval Trachea    19.175 Larval Carcass    19.65 Adult Head    9 Adult Eye    8.475 Adult Brain    9.9 Adult Thoracic-Abdominal Ganglion    9.7 Adult Crop    11.2 Adult Midgut    15.2 Adult Hindgut    5 Adult Malpighian Tubules    6.4 Adult Fat Body    3.5 Adult Salivary Gland    9.5 Adult Heart    3.275 Adult VirginFemale Spermatheca    4.2 Adult InseminatedFemale Spermatheca    4.2 Adult Ovary    198.6 Adult Testis    434.7 Adult Male Accessory Gland    12.6 Adult Carcass    8.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    9   NA  Eye    8.475   NA  Brain    9.9   74  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    9.7   NA  Crop    no informative data   6.7  Midgut    no informative data   no informative data  Hindgut    5   no informative data  Malpighian Tubules    6.4   no informative data  Fat Body    3.5   no informative data  Salivary Gland    9.5   NA  Heart    3.275   19.175  Trachea    NA   NA  VirginFemale Spermatheca    4.2   NA  InseminatedFemale Spermatheca    4.2   NA  Ovary    198.6   NA  Testis    434.7   NA  Male Accessory Gland    no informative data   19.65  Carcass    8.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    26 ovary, mated 4-day female    22 testis, mated 4-day male    70 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female  26 ovary, mated 4-day female    22 testis, mated 4-day male  (70) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    26 ovary, mated 4-day female    22 testis, mated 4-day male    70 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    26 ovary, mated 4-day female    22 testis, mated 4-day male    70 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    26 ovary, mated 4-day female    22 testis, mated 4-day male    70 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female  26 ovary, mated 4-day female    22 testis, mated 4-day male  (70) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    26 ovary, mated 4-day female    22 testis, mated 4-day male    70 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    5 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    10 fat body, pupae P8    6 carcass, larvae L3 wandering    2 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    26 ovary, mated 4-day female    22 testis, mated 4-day male    70 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day    41 adult male 30day    35 adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (30) embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr  (27) pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day  (41) adult male 30day  (35) adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day    41 adult male 30day    35 adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day    41 adult male 30day    35 adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day    41 adult male 30day    35 adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr  27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day  (41) adult male 30day  (35) adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day    41 adult male 30day    35 adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    30 embryo 02-04hr    9 embryo 04-06hr    24 embryo 06-08hr    13 embryo 08-10hr    9 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    3 larva L2    3 larva L3 12hr old    2 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    8 larva L3 puffstage 7-9    10 white prepupae new    9 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    19 pupae 4d postWPP    15 adult male 01day    24 adult male 05day    41 adult male 30day    35 adult female 01day    8 adult female 05day    19 adult female 30day    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    12 Schneider line 2 Sg4    7 embryonic 1182-4H    6 embryonic GM2    6 embryonic Kc167    17 embryonic S1    8 embryonic S3    9 leg disc CME L1    5 wing disc CME-W2    5 wing disc ML-DmD8    5 wing disc ML-DmD9    7 wing disc ML-DmD16-c3    8 wing disc ML-DmD21    10 wing disc ML-DmD32    6 haltere disc ML-DmD17-c3    8 eye-antennal disc ML-DmD11    7 antennal disc ML-DmD20-c5    9 mixed discs ML-DmD4-c1    6 CNS ML-DmBG1-c1    9 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    3 ovary fGS/OSS    15 ovary OSC    7 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    5 heat shock, 4-day adult    10 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    10 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    20 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005654 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4088-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal lat23G9 latlE34 latlE49 latlE311 latlE344 latlE352 latlE357 latlE372 latvr6.6 latvr6.35 lethal | pupal stage | recessive lat6 latlE49 latlE344 latvr6.6 latvr6.35 lethal | recessive lat1 lat2 lat3 lat4 lat5 lat6 lat7 viable latP1 Other Phenotypes Allele behavior defective | recessive latlE49 latlE344 latvr6.6 learning defective latP1 learning defective | recessive latP1 latP locomotor behavior defective | recessive latlE49 latlE344 latvr6.6 memory defective lat1 latE8 latE9 latE14 latE16b latE17 latlE34 latlE352 latlE357 latlE372 latvr6.6 latvr6.35 neuroanatomy defective | larval stage | recessive latlE49 latlE344 neurophysiology defective | larval stage | recessive latlE49 latlE344 latP1 latvr6.6 wild-type lat+t17.1 Phenotype manifest in Allele axon terminus latlE344 latlE49 border follicle cell | somatic clone lat23G9 bouton latlE344 latlE49 embryonic/larval central nervous system latlE344 latvr6.35 latvr6.6 imaginal disc latlE344 latvr6.35 latvr6.6 mushroom body latP1
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of lat Class Mutagen Stocks Known lesion lat1 ethyl methanesulfonate 3 -- lat6 gamma ray 3 Yes latEP1168 P-element activity 1 -- lat23G9 chemical 0 -- lat2 ethyl methanesulfonate 0 -- lat3 ethyl methanesulfonate 0 -- lat4 gamma ray 0 -- lat5 gamma ray 0 -- lat7 gamma ray 0 -- latE11 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE12 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE13 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE14 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE16a hypomorphic allele - genetic evidence Delta2-3 0 Yes latE16b hypomorphic allele - genetic evidence Delta2-3 0 Yes latE17 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE1 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE4 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE5 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE6 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE8 hypomorphic allele - genetic evidence Delta2-3 0 Yes latE9 hypomorphic allele - genetic evidence Delta2-3 0 Yes latle107 P-element activity 0 -- latlE311 Delta2-3 0 Yes latlE344 loss of function allele Delta2-3 0 Yes latlE34 Delta2-3 0 Yes latlE352 Delta2-3 0 Yes latlE357 Delta2-3 0 Yes latlE372 Delta2-3 0 Yes latlE49 loss of function allele Delta2-3 0 Yes latP1 hypomorphic allele - genetic evidence P-element activity PM hybrid dysgenesis 0 Yes latP2 P-element activity 0 -- latP P-element activity 0 -- latvr6.35 Delta2-3 0 Yes latvr6.6 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of lat Class Mutagen Stocks Known lesion latGD1272 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes latJF01915 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes latKK100894 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes lat+t17.1 in vitro construct - genomic fragment 0 Yes latNIG.4088R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC273 (Christensen and Cook, 2007.3.22) Df(2R)BSC878 (Cook and Cook, 2010.5.7) Df(2R)Exel8057 (Ryder, 2004.4.26) Df(2R)lE107 (Boynton and Tully, 1992) Df(2R)lE388 (Boynton and Tully, 1992) Df(2R)vg33 (Lasko and Pardue, 1988) Df(2R)vg56 (Pinto et al., 1999, Lasko and Pardue, 1988, Boynton and Tully, 1992, Hao et al., 1995) Df(2R)vg104 (Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg106 (Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg-B (Lasko and Pardue, 1988, Boynton and Tully, 1992, Wu and Howe, 1995, Hao et al., 1995) Df(2R)vg-P2 (Lasko and Pardue, 1988, Hao et al., 1995)
Not disrupted in	Df(2R)R7 (Lasko and Pardue, 1988) Df(2R)Su(z)2-1.a6 (Wu and Howe, 1995) Df(2R)Su(z)2-1.b8 (Wu and Howe, 1995) Df(2R)Su(z)25 (Wu and Howe, 1995) Df(2R)Su(z)3-1.iy (Wu and Howe, 1995) Df(2R)Su(z)3-1.jtg (Wu and Howe, 1995) Df(2R)vg62 (Lasko and Pardue, 1988, Wu and Howe, 1995) Df(2R)vg79b3 (Lasko and Pardue, 1988) Df(2R)vg79d8 (Lasko and Pardue, 1988) Df(2R)vg81 (Lasko and Pardue, 1988) Df(2R)vg83f15 (Lasko and Pardue, 1988) Df(2R)vg107 (Lasko and Pardue, 1988, Boynton and Tully, 1992) Df(2R)vg120 (Lasko and Pardue, 1988) Df(2R)vg124 (Lasko and Pardue, 1988) Df(2R)vg133 (Lasko and Pardue, 1988) Df(2R)vg135 (Lasko and Pardue, 1988) Df(2R)vg136 (Lasko and Pardue, 1988, Hao et al., 1995) Df(2R)vg-C (Lasko and Pardue, 1988) Df(2R)vg-D (Lasko and Pardue, 1988, Wu and Howe, 1995) In(2LR)vg79a (Lasko and Pardue, 1988)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1272} NA P{KK100894} NA P{NIG.4088R} NA P{TRiP.JF01915} NA characterization construct P{lat.3-1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}latEP1168 NA insertion of enhancer trap P{lacW}l(2)SH0065SH0065 No miscellaneous insertions P{?'wd19.3}latlE344 NA P{wd19.3}latP1 NA P{wd19.3-ΔlE49}latlE49 NA P{white-un2}latP NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Wang et al., 2006) centrosome duplication inferred from mutant phenotype (Müller et al., 2010) centrosome organization inferred from mutant phenotype (Müller et al., 2010) DNA replication initiation inferred from direct assay (Chesnokov et al., 1999)
Cellular Component
CV term Evidence References
mitotic spindle inferred from direct assay (Müller et al., 2010) nuclear origin of replication recognition complex inferred from direct assay (Chesnokov et al., 1999)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR020795 (FlyBase Curators et al., 2004-) non-traceable author statement (Sokolowski, 2001)
Biological Process
CV term Evidence References
DNA replication non-traceable author statement (Sokolowski, 2001) larval feeding behavior non-traceable author statement (Sokolowski, 2001) learning non-traceable author statement (Sokolowski, 2001) learning or memory non-traceable author statement (Sokolowski, 2001) olfactory learning traceable author statement (Roman and Davis, 2001)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex inferred from sequence or structural similarity with EMBL:AF125507 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2007) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
lat - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - Orc6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - Srp72 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - btz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - msn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) lat - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions lat allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62217 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005654 DroID - A comprehensive database of gene and protein interactions. • FBgn0005654 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36454
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68KRWR Dipteran inclusive ortholog search EOG6GQQD5 Insect inclusive ortholog search EOG6FQZMP Arthropod inclusive ortholog search EOG6C5B0G Metazoa inclusive ortholog search EOG6SJJ6T
Orthologs in Drosophila Species (EOG68KRWR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\lat     Drosophila simulans   Dsim\GD25785 Y   Drosophila sechellia   Dsec\GM20305 Y   Drosophila erecta   Dere\GG22519 Y   Drosophila yakuba   Dyak\GE13391 Y   Drosophila ananassae   Dana\GF12966 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17948 Y   Drosophila persimilis   Dper\GL17672 Y   Drosophila willistoni   Dwil\GK17892 Y   Drosophila virilis   Dvir\GJ21473 Y   Drosophila mojavensis   Dmoj\GI18396 Y   Drosophila grimshawi   Dgri\GH24942 Y
Orthologs in non-Drosophila Dipterans (EOG6GQQD5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004328   Anopheles gambiae Malaria mosquito  Agam\AGAP010406   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016431
Orthologs in non-Dipteran Insects (EOG6FQZMP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC100577998   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008683   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25963   Atta cephalotes Leafcutter ant  Acep\ACEP17531   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17954   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18306   Linepithema humile Argentine ant  Lhum\LH20003   Pogonomyrmex barbatus Red harvester ant  Pbar\PB27257   Solenopsis invicta Red fire ant  Sinv\SINV25592   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005669   Bombyx mori Silkmoth  Bmor\BGIBMGA000323   Pediculus humanus Human body louse  Phum\PHUM495710   Tribolium castaneum Red flour beetle  Tcas\TC013076
Orthologs in non-Insect Arthropods (EOG6C5B0G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_314277   Ixodes scapularis Deer tick  Isca\ISCW019131
Orthologs in non-Arthropod Metazoa (EOG6SJJ6T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000544gn   Danio rerio Zebrafish  Drer\orc3   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000019801   Gallus gallus Domestic chicken  Ggal\ORC3L   Mus musculus House mouse  Mmus\Orc3   Rattus norvegicus Norway rat  Rnor\Orc3   Homo sapiens Human  Hsap\ORC3
Human Orthologs (1)
Gene OMIM HGNC Hsap\ORC3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25785 Drosophila sechellia Dsec\GM20305 Drosophila erecta Dere\GG22519 Drosophila yakuba Dyak\GE13391 Drosophila ananassae Dana\GF12966 Drosophila pseudoobscura pseudoobscura Dpse\GA17948 Drosophila persimilis Dper\GL17672 Drosophila willistoni Dwil\GK17892 Drosophila virilis Dvir\GJ21473 Drosophila mojavensis Dmoj\GI18396 Drosophila grimshawi Dgri\GH24942
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	17214 w1118; P{EP}latEP1168 25876 y1 v1; P{TRiP.JF01915}attP2 5571 al1 b1 lat6 c1 sp1/SM5 5570 al1 b1 lat1 c1 sp1/CyO, sp*
Kyoto	108305 al1 b1 lat6 c1 sp1/SM5 101281 al1 b1 lat1 c1 sp1 / CyO 101282 al1 b1 lat6 c1 sp1 / SM5 108304 al1 b1 lat1 c1 sp1/CyO, sp*
VDRC	v103716 P{KK100894}VIE-260B v33197 w1118; P{GD1272}v33197
Genomic Clones ( 1 )
	BACR05M17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT22044 GH28787 LP02234
Other clones	DPiM_GH28787
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT23476 GH20855 GH25393 LD39766 LP14670 LP23279 RE39063 RH45794
Other clones	10567 53932 53936 84075 192903 bs40f03 bs75f06 EK110619 EK178010 EK218032 EK218903 EK296363 GM14657 LD45671 RE01424
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005654 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36454
Antibody Information
	polyclonal (Pinto et al., 1999, Chesnokov et al., 1999)
Other Information
Discoverer
Etymology
	'latheo' is Greek for "to cause a person not to know". (DiAntonio, 1999) "latheo" is Greek: "to cause a person not to know" (Benet's Reader's Encyclopedia 1987). (Boynton and Tully, 1992) Named after a Greek word, meaning "forgetful", related to the name of one of the rivers of Hades, Lethe, whose waters caused all those who drank from them to forget their former life. (Greenspan, 1995)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: lat Orc3 (Pinto et al., 1999)
Additional comments	One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by lat (CG4088) and CG34315 (CG34315). (FlyBase Genome Annotators, 2007)
Other Comments
	The lat gene product functions in DNA replication during cell proliferation. (Pinto et al., 1999) Cessation of cell proliferation in third instar larvae defines the phenotypic defect of null mutations in the lat gene. (Pinto et al., 1999) The lat gene product is specifically localised to the synaptic boutons. (Rohrbough et al., 1999) The lat gene product plays a central role in regulating Ca2+- and activity-dependent synaptic plasticity. (Rohrbough et al., 1999) Basal synaptic transmission amplitude at the lat mutant NMJ is elevated 3 to 4 fold, and Ca2+ dependence of transmission is significantly reduced. Multiple forms of synaptic facilitation and posttetanic potentiation are strongly depressed or absent at the mutant synapse. (Rohrbough et al., 1999) Genetic dissection of the learning and memory gene lat. (Boynton and Tully, 1992) lat is involved in the middle term component of memory formation (MTM). (Tully et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057556 NM_165971 RefSeq (Proteins) • NP_476904 NP_725260 DDBJ / EMBL / GenBank • AAD32712 AAD39472 AAD47349 AAF58411 AAL28365 AAM68599 AAY82232 AAY82233 AC005655 AF139062 AF152093 AF153209 AI517734 AQ254825 AW941102 AY060817 DQ017454 DQ017455 Entrez Gene - A searchable database of RefSeq genes. • 45 36454 UniProtKB/TrEMBL • Q3YNA4 Q7K2L1 Q9TVK9 Q9Y1B4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Origin recognition complex, subunit 3 (IPR020795) GO • GO:5664 GO:6270
Linkouts
	BioGRID - A database of protein and genetic interactions • 62217 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005654 DroID - A comprehensive database of gene and protein interactions. • FBgn0005654 DRSC - Results from RNAi screens. • FBgn0005654 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005654 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4088-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005654 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36454 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/latheo1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36454 modMine - Data generated by the modENCODE project. • FBgn0005654
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	CG4088 (FlyBase Genome Annotators, 2007, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5) DmORC3 (Chesnokov et al., 1999, Pak et al., 1997) DmOrc3 (Clarey et al., 2006) l(2)49Fd (Hao et al., 1995, Lasko and Pardue, 1988, ) l(2)vr6   lat (FlyBase Genome Annotators, 2007, Christensen and Cook, 2007.3.22, van Swinderen, 2007, Doheny et al., 2008, Seugnet et al., 2009, Cook and Cook, 2010.5.7, Brown and Feder, 2005, Neumüller et al., 2011, Müller et al., 2010, Japanese National Institute of Genetics, 2012.5.21) LAT (Dubnau et al., 2003) ORC (Bielinsky et al., 2001, Wakimoto, 1998, Huang and Kellum, 1997) ORC3 (Badugu et al., 2003, Chesnokov, 1999.3.30, Wallrath, 1998, Badugu et al., 2005, Li et al., 2002, Park and Asano, 2008) Orc3 (Adams et al., 2000, Doheny et al., 2008, Cayirlioglu et al., 2003, Maqbool et al., 2010) vr6 (Renn et al., 1998, Boynton and Tully, 1992) vr-6 (Duronio et al., 1998)
Name Synonym	latheo (Doheny et al., 2008, Ehlers, 2005, Dubnau et al., 2003, Guo and Zhong, 2006, Seugnet et al., 2009, Wang et al., 2006) Origin recognition complex subunit 3 (Pak et al., 1997, Doheny et al., 2008)
Secondary FlyBase IDs
	FBgn0002075 FBgn0004955 FBgn0023182
References ( 91 )
Generate a list of	All references relating to this gene ( 91 )
List References by type	Research paper  ( 32 ) Supplementary material  ( 3 ) Review  ( 23 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 ) Letter  ( 1 )
Recent research papers ( 2 )
	Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...