General Information Symbol Dmel\ latSpecies D. melanogaster Name latheo Annotation symbol CG4088 Feature type protein_coding_gene FlyBase ID FBgn0005654 Gene Model Status Current Stock availability 10 publicly
available Also Known As ORC3, ORC, DmORC3, vr6, l(2)49Fd Genomic Location Chromosome (arm) 2R Recombination map Cytogenetic map 49F7-49F8 Sequence location 2R:9,090,233..9,094,027 [-]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
latheo is referred to in FlyBase by the symbol
Dmel\lat (CG4088, FBgn0005654). It is a protein_coding_gene from
Drosophila melanogaster . It is reported to have
molecular function : DNA binding. There is experimental evidence that it is involved in the
biological process : centrosome organization; DNA replication initiation; border follicle cell migration; centrosome duplication.
40 alleles are reported . The
phenotypes of these alleles are annotated with: mushroom body; bouton; axon terminus; imaginal disc; embryonic/larval central nervous system. It has
2 annotated transcripts and
2 annotated polypeptides .
Protein features are: Origin recognition complex, subunit 3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages, at stages throughout the pupal period, in stages of adults of both sexes. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1627828_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of lat expression signal. See the GBrowse view of lat to determine the overlapping gene(s). Gene sequence location is
2R:9090233..9094027 .
User Contributed Data External Summaries
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
49F-49F
(determined by in situ hybridisation)
49F7-49F8
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.44
Gene model reviewed during 5.46
gene_with_dicistronic_mRNA ; SO:0000722
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) 721 (aa); 79 (kD observed)
Comments lat protein was isolated from purified ORC (origin recognition complex) from 0-12hr embryos. The six-subunit ORC can be reconstituted with recombinant proteins into a complex that restores DNA replication in ORC-depleted Drosophila or Xenopus extracts.
External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript Expression
Additional Descriptive Data
lat message is detected in the adult brain.
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
lat protein is widely distributed in the adult brain, with higher levels in the central brain.
lat protein is detected in all subtypes of synaptic boutons at larval neuromuscular junctions. Colocalization with the presynaptic-vesicle associated
Csp protein indicates that
lat protein is restricted to the presynaptic compartment.
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
High
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
74
Larval Midgut
6.7
Larval Hindgut
11.4
Larval Malpighian Tubules
11.3
Larval Fat Body
64.2
Larval Salivary Gland
14.1
Larval Trachea
19.175
Larval Carcass
19.65
Adult Head
9
Adult Eye
8.475
Adult Brain
9.9
Adult Thoracic-Abdominal Ganglion
9.7
Adult Crop
11.2
Adult Midgut
15.2
Adult Hindgut
5
Adult Malpighian Tubules
6.4
Adult Fat Body
3.5
Adult Salivary Gland
9.5
Adult Heart
3.275
Adult VirginFemale Spermatheca
4.2
Adult InseminatedFemale Spermatheca
4.2
Adult Ovary
198.6
Adult Testis
434.7
Adult Male Accessory Gland
12.6
Adult Carcass
8.2
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
9
NA
Eye
8.475
NA
Brain
9.9
74
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
9.7
NA
Crop
no informative data
6.7
Midgut
no informative data
no informative data
Hindgut
5
no informative data
Malpighian Tubules
6.4
no informative data
Fat Body
3.5
no informative data
Salivary Gland
9.5
NA
Heart
3.275
19.175
Trachea
NA
NA
VirginFemale Spermatheca
4.2
NA
InseminatedFemale Spermatheca
4.2
NA
Ovary
198.6
NA
Testis
434.7
NA
Male Accessory Gland
no informative data
19.65
Carcass
8.2
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
70
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(31)
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
(70)
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
70
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
70
accessory gland, mated 4-day male
9
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
70
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
(70)
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
70
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
31
central nervous system, larvae L3
5
central nervous system, pupae P8
1
head, virgin 1-day female
0
head, virgin 4-day female
0
head, virgin 20-day female
0
head, mated 1-day female
1
head, mated 4-day female
0
head, mated 20-day female
0
head, mated 1-day male
1
head, mated 4-day male
0
head, mated 20-day male
1
salivary gland, larvae L3 wandering
0
salivary gland, white prepupae
2
digestive system, larvae L3 wandering
1
digestive system, 1-day adult
1
digestive system, 4-day adult
1
digestive system, 20-day adult
1
fat body, larvae L3 wandering
0
fat body, white prepupae
10
fat body, pupae P8
6
carcass, larvae L3 wandering
2
carcass, 1-day adult
1
carcass, 4-day adult
1
carcass, 20-day adult
1
ovary, virgin 4-day female
26
ovary, mated 4-day female
22
testis, mated 4-day male
70
accessory gland, mated 4-day male
9
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
41
adult male 30day
35
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(30)
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
(27)
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
(41)
adult male 30day
(35)
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
41
adult male 30day
35
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
41
adult male 30day
35
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
41
adult male 30day
35
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
(41)
adult male 30day
(35)
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
41
adult male 30day
35
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
30
embryo 02-04hr
9
embryo 04-06hr
24
embryo 06-08hr
13
embryo 08-10hr
9
embryo 10-12hr
5
embryo 12-14hr
3
embryo 14-16hr
2
embryo 16-18hr
1
embryo 18-20hr
1
embryo 20-22hr
1
embryo 22-24hr
1
larva L1
3
larva L2
3
larva L3 12hr old
2
larva L3 puffstage 1-2
4
larva L3 puffstage 3-6
8
larva L3 puffstage 7-9
10
white prepupae new
9
white prepupae 12hr
18
white prepupae 24hr
27
pupae 2d postWPP
25
pupae 3d postWPP
19
pupae 4d postWPP
15
adult male 01day
24
adult male 05day
41
adult male 30day
35
adult female 01day
8
adult female 05day
19
adult female 30day
20
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
12
Schneider line 2 Sg4
7
embryonic 1182-4H
6
embryonic GM2
6
embryonic Kc167
17
embryonic S1
8
embryonic S3
9
leg disc CME L1
5
wing disc CME-W2
5
wing disc ML-DmD8
5
wing disc ML-DmD9
7
wing disc ML-DmD16-c3
8
wing disc ML-DmD21
10
wing disc ML-DmD32
6
haltere disc ML-DmD17-c3
8
eye-antennal disc ML-DmD11
7
antennal disc ML-DmD20-c5
9
mixed discs ML-DmD4-c1
6
CNS ML-DmBG1-c1
9
CNS ML-DmBG2-c2
7
tumorous blood cells mbn2
3
ovary fGS/OSS
15
ovary OSC
7
ovary OSS
4
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
6
cold shock, 4-day adult
5
heat shock, 4-day adult
10
Cadmium 50 mM 6 hrs, larvae L3
2
Cadmium 50 mM 12 hrs, larvae L3
3
Cadmium 50 mM 48 hrs, 4-day adult
8
Cadmium 100 mM 48 hrs, 4-day adult
18
Copper 0.5 mM 12 hrs, larvae L3
2
Copper 15 mM 48 hrs, 4-day adult
10
Zinc 5 mM 12 hrs, larvae L3
1
Zinc 4.5 mM 48 hrs, 4-day adult
9
Ethanol 2.5% 3 hrs, larvae L3
22
Ethanol 5% 3 hrs, larvae L3
2
Ethanol 10% 3 hrs, larvae L3
1
Caffeine 1.5 mg/ml 4 hrs, larvae L3
2
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
17
Caffeine 25 mg/ml 48 hrs, 4-day adult
6
Paraquat 5 mM 48 hrs, 4-day adult
20
Paraquat 10 mM 48 hrs, 4-day adult
19
Rotenone 2 μg 12 hrs, larvae L3
2
Rotenone 8 μg 12 hrs, larvae L3
3
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 35 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 5 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Not disrupted in Transgenic Constructs & Insertions
Transgenic Constructs characterization construct
Insertions insertion of mobile activating element
insertion of enhancer trap
Gene Ontology: Function, Process
& Cellular Component ( 12 unique terms ) Terms Based on
Experimental Evidence ( 6 terms ) Molecular Function ( 0 terms) Biological Process inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Cellular Component inferred from direct assay
inferred from direct assay
Terms Based on Predictions or
Assertions ( 7 terms ) Molecular Function non-traceable author statement
Biological Process non-traceable author statement
non-traceable author statement
non-traceable author statement
non-traceable author statement
traceable author statement
Cellular Component inferred from sequence or structural similarity with
EMBL:AF125507 Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (37)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG68KRWR )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6GQQD5 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6FQZMP )
Apis mellifera
Western honey bee
Amel\LOC100577998
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008683
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH25963
Atta cephalotes
Leafcutter ant
Acep\ACEP17531
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO17954
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL18306
Linepithema humile
Argentine ant
Lhum\LH20003
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB27257
Solenopsis invicta
Red fire ant
Sinv\SINV25592
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6C5B0G )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6SJJ6T )
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 10 )Bloomington Kyoto VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 27 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology 'latheo' is Greek for "to cause a person not to know".
"latheo" is Greek: "to cause a person not to know" (Benet's Reader's Encyclopedia 1987).
Named after a Greek word, meaning "forgetful", related to the name of one of the rivers of Hades, Lethe, whose waters caused all those who drank from them to forget their former life.
Identification Relationship to Other Genes Source for database identity of Source for database merge of Source for merge of: lat Orc3
Additional comments One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by
lat (CG4088) and
CG34315 (CG34315).
Other Comments The
lat gene product functions in DNA replication during cell proliferation.
Cessation of cell proliferation in third instar larvae defines the phenotypic defect of null mutations in the
lat gene.
The
lat gene product is specifically localised to the synaptic boutons.
The
lat gene product plays a central role in regulating Ca
2+ - and activity-dependent synaptic plasticity.
Basal synaptic transmission amplitude at the
lat mutant NMJ is elevated 3 to 4 fold, and Ca
2+ dependence of transmission is significantly reduced. Multiple forms of synaptic facilitation and posttetanic potentiation are strongly depressed or absent at the mutant synapse.
Genetic dissection of the learning and memory gene lat.
lat is involved in the middle term component of memory formation (MTM).
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
- A cyberspace guide to Drosophila development and metazoan evolution
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 14 )Reported As Symbol Synonym lat
(
FlyBase Genome Annotators, 2007 ,
Christensen and Cook, 2007.3.22 ,
van Swinderen, 2007 ,
Doheny et al., 2008 ,
Seugnet et al., 2009 ,
Cook and Cook, 2010.5.7 ,
Brown and Feder, 2005 ,
Neumüller et al., 2011 ,
Müller et al., 2010 ,
Japanese National Institute of Genetics, 2012.5.21 )
ORC3
(
Badugu et al., 2003 ,
Chesnokov, 1999.3.30 ,
Wallrath, 1998 ,
Badugu et al., 2005 ,
Li et al., 2002 ,
Park and Asano, 2008 )
Name Synonym latheo
(
Doheny et al., 2008 ,
Ehlers, 2005 ,
Dubnau et al., 2003 ,
Guo and Zhong, 2006 ,
Seugnet et al., 2009 ,
Wang et al., 2006 )
Origin recognition complex subunit 3
Secondary FlyBase
IDs FBgn0002075 FBgn0004955 FBgn0023182 References ( 91 )Generate a list of List References by type
Recent research papers ( 2 )
Weber et al., 2012, PLoS ONE 7(4): e34745Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011