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Gene Dmel\mus209

General Information
Symbol	Dmel\mus209	Species	D. melanogaster
Name	mutagen-sensitive 209	Annotation symbol	CG9193
Feature type	protein_coding_gene	FlyBase ID	FBgn0005655
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	pcna, l(2)02448, dPCNA, DmPCNA
Genomic Location
Chromosome (arm)	2R	Recombination map	2-92.3
Cytogenetic map	56F11-56F11	Sequence location	2R:16,149,259..16,150,362 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mutagen-sensitive 209 is referred to in FlyBase by the symbol Dmel\mus209 (CG9193, FBgn0005655). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: DNA polymerase processivity factor activity; DNA binding. There is experimental evidence that it is involved in the biological process: mitotic spindle organization; DNA replication; antimicrobial humoral response; neurogenesis. 48 alleles are reported. The phenotypes of these alleles are annotated with: chromosome, centromeric region; ovariole; mitotic cell cycle; ovary; macrochaeta; prothoracic leg; follicle cell; spindle; mitotic metaphase; posterior scutellar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Proliferating cell nuclear antigen, PCNA; Proliferating cell nuclear antigen, PCNA, C-terminal; Proliferating cell nuclear antigen, PCNA, N-terminal; Proliferating cell nuclear antigen, PCNA, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval trachea, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623545_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of mus209. Gene sequence location is 2R:16149259..16150362.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)56Fa Recessive lethal; no phenotype in heterozygote, except when heterozygous to l(2)56Fb in which case short thin bristles are observed. mus209 Larval survival hypersensitive to exposure to methyl methanesulfonate and gamma rays, but not to N-acetyl-2-aminofluorene, benzo[a]pyrene, or nitrogen mustard.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA07653 BKN28382 References Hsieh et al., 2010, PLoS Genet. 6(8):
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56F11-56F11   Limits computationally determined from genome sequence between P{lacW}Ate1k10809 and P{EP}CG10444EP951
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56F10-56F11   (determined by in situ hybridisation)   (Spradling et al., 1999) 56F10-56F11   56F10--12 56F10--13 56F10--14 56F11--14   (BDGP Project Members, 1994-1999) 56E-56F   (determined by in situ hybridisation)   (Yamaguchi et al., 1990)
Experimentally Determined Recombination Data
Location	2-92.3
Left of (cM)	M(2)56F
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mus209 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mus209-RA FBtr0086307  NM_057557   1044   260 mus209-RB FBtr0086308  NM_206182   997   260
Additional Transcript Data & Comments
Reported size (kB)	1.1 (northern blot) (Yamaguchi et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mus209-PA   FBpp0085619   28.8   260   4.41     NP_476905   AAF57493 mus209-PB   FBpp0089395   28.8   260   4.41     NP_995904   AAS64796
Additional Polypeptide Data & Comments
Reported size (kDa)	260 (aa); 28.8 (kD predicted) (Yamaguchi et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proliferating cell nuclear antigen, PCNA (IPR000730) Proliferating cell nuclear antigen, PCNA, N-terminal (IPR022648) Proliferating cell nuclear antigen, PCNA, C-terminal (IPR022649) Proliferating cell nuclear antigen, PCNA, conserved site (IPR022659)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201634   AA440162   AA441366   AA951527   AE013599 AAF57493   AE013599 AAS64796   AC004321   AI512778   AI513872   AI516079   AI520047   AI542030   AQ073269   AW943811   AY122197 AAM52709   AY167137 AAO17673   AY231764   BG635899   BG636874   BI164783   BI212302   BI212730   BI230098   BI232525   BI239158   BI354304   BI354328   BI357154   BI357593   BI358618   BI362202   BI485430   BI632310   BI632766   BI634012   BI639018   BI641616   BP549478   BP554944   CK658786   CL632183   CO271365   CO316587   EC060060   EC209972   EC221070   EC221378   EC249848   EL870693   EV579745   EV580173   EV583248   EV584790   EV590930   EV593026   EV600805   GH749774   GH750000   GH750007   GH752518   GH753893   GH754952   GH757393   GH757496   GH758927   GH759120   GH759997   GH760350   GH760817   GH760827   GH761140   GH771896   GH774267   GH774292   GH775199   GH775425   GH775675   GH778753   GH778914   GH783788   GH783803   GH783850   GH785187   GH786684   GH787379   GH787985   GH788149   GH788374   GH789363   GH790489   GH790628   GH793160   GH794228   GH794481   GH794598   GH797546   GH797631   GH799846   GH799875   GH801545   GH801923   GH803241   GH804095   GH804100   GH804402   GH805709   GH808036   GH809965   GH810727   GH810977   GH811972   GH812750   GH813556   GH813671   GH813919   GH815053   GH815336   GH815582   GH815714   GH815977   GH816566   GH816783   GH818979   GH819444   GH820000   GH820026   GH820769   GH821521   GH822247   GH822299   GH823337   GH823432   GH825702   GH826100   GH826842   GH828023   GH828573   GH829575   GH830213   GH830243   GH830986   GH832978   GH833252   GH833522   GH833891   GH834591   GH839926   GH840505   GH840617   GH841197   GH842147   GH842970   GH843806   GH845183   GH846212   GH846582   GH848709   GH849568   GH850324   GH850569   GH852176   GH852269   GH854479   GH854863   GH855063   GH855251   GH855695   GH855993   GH856117   GH856827   GH858882   GH859316   GH859839   GH860440   GH862179   GH862488   GH863557   GH864246   GH864355   GH864600   GH866678   GH866786   GH866934   GH867120   GH867461   GH868274   GH868809   GH868865   GH869722   GH870562   GH871253   GH872963   GH873278   GH873653   GH873669   GH875206   GH875485   GH876538   GH877501   GH879280   GH879993   GH880794   GH882686   GH883755   GH885051   GH885078   GH886437   GH887311   GH887564   GH888736   GH889489   GH889797   GH889855   GH890138   GH890311   GH890487   GH890652   GH892303   GH893171   GH893287   GH894558   GH896042   GH896956   GH897779   GH897849   GH899996   GH900536   GH903450   GH904857   GH905002   GH905608   GH905793   GH906301   GH906324   GH906494   GH906943   GH908340   GH909148   GH909705   GH911494   GH912692   GH912887   GH913670   GH914318   GH914951   GH918994   GH919706   GH920727   GH922957   GH923184   GH923701   GH924508   GH925389   GH927050   GH927427   GH928581   GH929024   GH929313   GH930034   GH930404   GH931315   GH932206   GH933519   GH933539   GH933740   GH933975   GH934988   GH935700   GH938154   GH939077   GH939459   GH940567   GH942581   M33950 AAA28746
UniProtKB/Swiss-Prot	P17917
UniProtKB/TrEMBL	Q868I9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159860 2R:16,150,636..16,150,658 evidence=experimental comment=EVE/ZEN binding region I; the reference sequence contains a 5 bp deletion when compared to the sequence presented in FBrf0052576 bound_moiety=eve-XP comment=EVE/ZEN binding region I; the reference sequence contains a 5 bp deletion when compared to the sequence presented in FBrf0052576; DNaseI protection assay. bound_moiety=eve+P376 (Yamaguchi et al., 1990, Bergman et al., 2004) protein binding site FBsf0000159858 2R:16,150,597..16,150,613 evidence=experimental comment=EVE/ZEN binding region II; the reference sequence differs by 1 bp from the sequence presented in FBrf0052576 bound_moiety=eve-XP comment=EVE/ZEN binding region II; the reference sequence differs by 1 bp from the sequence presented in FBrf0052576; DNaseI protection assay. bound_moiety=eve+P376 (Yamaguchi et al., 1990, Bergman et al., 2004) protein binding site FBsf0000159859 2R:16,150,493..16,150,537 evidence=experimental comment=EVE/ZEN binding region III comment=EVE/ZEN binding region III; DNaseI protection assay. bound_moiety=eve-XP bound_moiety=eve+P376 (Yamaguchi et al., 1990, Bergman et al., 2004) protein binding site FBsf0000159936 2R:16,150,442..16,150,449 bound_moiety=CFDD-XP evidence=experimental (Hayashi et al., 1997) protein binding site FBsf0000159949 2R:16,150,433..16,150,445 bound_moiety=grh-XP evidence=experimental (Hayashi et al., 1999) protein binding site FBsf0000159950 2R:16,150,408..16,150,415 bound_moiety=CFDD-XP evidence=experimental (Hayashi et al., 1997) protein binding site FBsf0000159951 2R:16,150,392..16,150,399 bound_moiety=CFDD-XP evidence=experimental (Hayashi et al., 1997) protein binding site FBsf0000159952 2R:16,150,364..16,150,371 bound_moiety=E2f-XP evidence=experimental (Yamaguchi et al., 1995) protein binding site FBsf0000159953 2R:16,150,351..16,150,358 bound_moiety=E2f-XP evidence=experimental (Yamaguchi et al., 1995)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12   peripheral nervous system   (Du and Dyson, 1999) embryonic stage 13   hindgut   (Fuss et al., 2001) Comment:excluded from rectum primordium northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Yamaguchi et al., 1990) oogenesis & adult stage | female   ovary   (Yamaguchi et al., 1990)
Additional Descriptive Data
	The highest levels of mus209 expression are seen at 0-10 hours of embryogenesis. The levels of the mus209 transcript are lower later in embryogenesis through second instar larval stages, and decrease further in third instar larval to adult stages. The high levels of mus209 transcript in adult ovaries, and in unfertilized eggs laid by virgin females suggests that the high levels of transcript in early embryogenesis are maternally contributed. (Yamaguchi et al., 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference fertilized egg stage   male pronucleus   • chromatin (Loppin et al., 2001) Comment:interphase female pronucleus   • chromatin (Loppin et al., 2001) Comment:interphase
Additional Descriptive Data
	mus209 and DNApol-alpha73 proteins are detected associated with the nuclear chromatin of interphase apposed male and female pro-nuclei in newly fertilized eggs in preparation for the completion of DNA replication prior to the first zygotic division. (Loppin et al., 2001)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0005655    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0005655 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0005655 expression level Developmental Stage   Expression Level embryo 00-02hr    40122 embryo 02-04hr    32761 embryo 04-06hr    44561 embryo 06-08hr    32536 embryo 08-10hr    20435 embryo 10-12hr    8885 embryo 12-14hr    4401 embryo 14-16hr    5447 embryo 16-18hr    3538 embryo 18-20hr    1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1    8291 larva L2    6288 larva L3 12hr old    3736 larva L3 puffstage 1-2    4651 larva L3 puffstage 3-6    5235 larva L3 puffstage 7-9    5598 white prepupae new    5018 white prepupae 12hr    9333 white prepupae 24hr    6158 pupae 2d postWPP    1500 pupae 3d postWPP    835 pupae 4d postWPP    2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day    13893 adult female 05day    20382 adult female 30day    20955 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (40122) embryo 02-04hr  (32761) embryo 04-06hr  (44561) embryo 06-08hr  (32536) embryo 08-10hr  (20435) embryo 10-12hr  (8885) embryo 12-14hr  (4401) embryo 14-16hr  (5447) embryo 16-18hr  (3538) embryo 18-20hr  (1873) embryo 20-22hr  (1124) embryo 22-24hr  (1355) larva L1  (8291) larva L2  (6288) larva L3 12hr old  (3736) larva L3 puffstage 1-2  (4651) larva L3 puffstage 3-6  (5235) larva L3 puffstage 7-9  (5598) white prepupae new  (5018) white prepupae 12hr  (9333) white prepupae 24hr  (6158) pupae 2d postWPP  (1500) pupae 3d postWPP  (835) pupae 4d postWPP  (2401) adult male 01day  (840) adult male 05day  (940) adult male 30day  (1110) adult female 01day  (13893) adult female 05day  (20382) adult female 30day  (20955) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40122) embryo 02-04hr  (32761) embryo 04-06hr  (44561) embryo 06-08hr  (32536) embryo 08-10hr  (20435) embryo 10-12hr  (8885) embryo 12-14hr  (4401) embryo 14-16hr  (5447) embryo 16-18hr  (3538) embryo 18-20hr  (1873) embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1  (8291) larva L2  (6288) larva L3 12hr old  (3736) larva L3 puffstage 1-2  (4651) larva L3 puffstage 3-6  (5235) larva L3 puffstage 7-9  (5598) white prepupae new  (5018) white prepupae 12hr  (9333) white prepupae 24hr  (6158) pupae 2d postWPP  1500 pupae 3d postWPP    835 pupae 4d postWPP  (2401) adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day  (13893) adult female 05day  (20382) adult female 30day  (20955) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (40122) embryo 02-04hr  (32761) embryo 04-06hr  (44561) embryo 06-08hr  (32536) embryo 08-10hr  (20435) embryo 10-12hr    8885 embryo 12-14hr    4401 embryo 14-16hr    5447 embryo 16-18hr    3538 embryo 18-20hr    1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1    8291 larva L2    6288 larva L3 12hr old    3736 larva L3 puffstage 1-2    4651 larva L3 puffstage 3-6    5235 larva L3 puffstage 7-9    5598 white prepupae new    5018 white prepupae 12hr    9333 white prepupae 24hr    6158 pupae 2d postWPP    1500 pupae 3d postWPP    835 pupae 4d postWPP    2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day  (13893) adult female 05day  (20382) adult female 30day  (20955) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40122 embryo 02-04hr    32761 embryo 04-06hr    44561 embryo 06-08hr    32536 embryo 08-10hr    20435 embryo 10-12hr    8885 embryo 12-14hr    4401 embryo 14-16hr    5447 embryo 16-18hr    3538 embryo 18-20hr    1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1    8291 larva L2    6288 larva L3 12hr old    3736 larva L3 puffstage 1-2    4651 larva L3 puffstage 3-6    5235 larva L3 puffstage 7-9    5598 white prepupae new    5018 white prepupae 12hr    9333 white prepupae 24hr    6158 pupae 2d postWPP    1500 pupae 3d postWPP    835 pupae 4d postWPP    2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day    13893 adult female 05day    20382 adult female 30day    20955 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0005655 expression level Developmental Stage   Expression Level embryo 00-02hr    40122 embryo 02-04hr    32761 embryo 04-06hr    44561 embryo 06-08hr    32536 embryo 08-10hr    20435 embryo 10-12hr    8885 embryo 12-14hr    4401 embryo 14-16hr    5447 embryo 16-18hr    3538 embryo 18-20hr    1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1    8291 larva L2    6288 larva L3 12hr old    3736 larva L3 puffstage 1-2    4651 larva L3 puffstage 3-6    5235 larva L3 puffstage 7-9    5598 white prepupae new    5018 white prepupae 12hr    9333 white prepupae 24hr    6158 pupae 2d postWPP    1500 pupae 3d postWPP    835 pupae 4d postWPP    2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day    13893 adult female 05day    20382 adult female 30day    20955 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (40122) embryo 02-04hr  (32761) embryo 04-06hr  (44561) embryo 06-08hr  (32536) embryo 08-10hr  (20435) embryo 10-12hr  (8885) embryo 12-14hr  (4401) embryo 14-16hr  (5447) embryo 16-18hr  (3538) embryo 18-20hr  (1873) embryo 20-22hr  (1124) embryo 22-24hr  (1355) larva L1  (8291) larva L2  (6288) larva L3 12hr old  (3736) larva L3 puffstage 1-2  (4651) larva L3 puffstage 3-6  (5235) larva L3 puffstage 7-9  (5598) white prepupae new  (5018) white prepupae 12hr  (9333) white prepupae 24hr  (6158) pupae 2d postWPP  (1500) pupae 3d postWPP  (835) pupae 4d postWPP  (2401) adult male 01day  (840) adult male 05day  (940) adult male 30day  (1110) adult female 01day  (13893) adult female 05day  (20382) adult female 30day  (20955) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (40122) embryo 02-04hr  (32761) embryo 04-06hr  (44561) embryo 06-08hr  (32536) embryo 08-10hr  (20435) embryo 10-12hr  (8885) embryo 12-14hr  (4401) embryo 14-16hr  (5447) embryo 16-18hr  (3538) embryo 18-20hr  1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1  (8291) larva L2  (6288) larva L3 12hr old  (3736) larva L3 puffstage 1-2  (4651) larva L3 puffstage 3-6  (5235) larva L3 puffstage 7-9  (5598) white prepupae new  (5018) white prepupae 12hr  (9333) white prepupae 24hr  (6158) pupae 2d postWPP  1500 pupae 3d postWPP    835 pupae 4d postWPP  2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day  (13893) adult female 05day  (20382) adult female 30day  (20955) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (40122) embryo 02-04hr  (32761) embryo 04-06hr  (44561) embryo 06-08hr  (32536) embryo 08-10hr  20435 embryo 10-12hr    8885 embryo 12-14hr    4401 embryo 14-16hr    5447 embryo 16-18hr    3538 embryo 18-20hr    1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1    8291 larva L2    6288 larva L3 12hr old    3736 larva L3 puffstage 1-2    4651 larva L3 puffstage 3-6    5235 larva L3 puffstage 7-9    5598 white prepupae new    5018 white prepupae 12hr    9333 white prepupae 24hr    6158 pupae 2d postWPP    1500 pupae 3d postWPP    835 pupae 4d postWPP    2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day  13893 adult female 05day  20382 adult female 30day  (20955) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    40122 embryo 02-04hr    32761 embryo 04-06hr    44561 embryo 06-08hr    32536 embryo 08-10hr    20435 embryo 10-12hr    8885 embryo 12-14hr    4401 embryo 14-16hr    5447 embryo 16-18hr    3538 embryo 18-20hr    1873 embryo 20-22hr    1124 embryo 22-24hr    1355 larva L1    8291 larva L2    6288 larva L3 12hr old    3736 larva L3 puffstage 1-2    4651 larva L3 puffstage 3-6    5235 larva L3 puffstage 7-9    5598 white prepupae new    5018 white prepupae 12hr    9333 white prepupae 24hr    6158 pupae 2d postWPP    1500 pupae 3d postWPP    835 pupae 4d postWPP    2401 adult male 01day    840 adult male 05day    940 adult male 30day    1110 adult female 01day    13893 adult female 05day    20382 adult female 30day    20955 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0005655    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0005655 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval hindgut, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0005655 expression level Tissue   Expression Level Larval Central Nervous System    848 Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland    528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1280.4 Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (848) Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland  528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (1280.4) Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    848 Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland    528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (1280.4) Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    848 Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland    528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1280.4 Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0005655 expression level Tissue   Expression Level Larval Central Nervous System    848 Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland    528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1280.4 Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (848) Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland  528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (1280.4) Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    848 Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland    528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  1280.4 Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    848 Larval Midgut    72.9 Larval Hindgut    183.2 Larval Malpighian Tubules no informative data Larval Fat Body    85.8 Larval Salivary Gland    528.5 Larval Trachea    374.3 Larval Carcass    215.425 Adult Head    31.4 Adult Eye no informative data Adult Brain    4.3 Adult Thoracic-Abdominal Ganglion    9.2 Adult Crop no informative data Adult Midgut    52.7 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland    4.3 Adult Heart    4.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    1280.4 Adult Testis    97.4 Adult Male Accessory Gland    2.9 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.4   NA  Eye    no informative data   NA  Brain    4.3   848  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    9.2   NA  Crop    no informative data   72.9  Midgut    52.7   183.2  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   85.8  Fat Body    no informative data   528.5  Salivary Gland    4.3   NA  Heart    4.75   374.3  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1280.4   NA  Testis    97.4   NA  Male Accessory Gland    2.9   215.425  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005655 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9193-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mus209 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 mus209GD4205 lethal (with Df(2R)173) mus209775 mus209D-292 lethal | cold sensitive mus209D-1368 lethal | heat sensitive mus2092735 mus209B1 lethal | pupal stage | recessive | cold sensitive mus209D-1368 lethal | recessive mus20904 mus20936 mus209157 mus209775 mus2091991 mus20902448 mus20902697 mus2092735 mus20906652 mus209D-91 mus209D-292 mus209D-932 mus209D-1368 mus209DR15 mus209k00501 mus209k00704 mus209k05313 mus209k05317 mus209k05328 mus209k06130 mus209k10504 mus209s1534 lethal | recessive | heat sensitive mus2092735 mus209B1 Sterility Allele female sterile mus209B1 female sterile | recessive mus2092735 mus209B1 mus209D-1368 Other Phenotypes Allele DNA repair defective mus209B1 DNA repair defective | female mus2092735 neuroanatomy defective | larval stage, with Scer\GAL41407 mus209GD4205 suppressor of variegation mus209D-1368 wild-type mus209+t5.2 mus209+t5 mus209+t6.5 mus209+t7 Phenotype manifest in Allele chromosome, centromeric region mus20902448 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 mus209GD4205 follicle cell mus2092735 mus209B1 ganglion mother cell | larval stage, with Scer\GAL41407 mus209GD4205 macrochaeta, with Scer\GAL4sca-109-68 mus209KK108382 mitosis & nuclear chromosome mus20902448 mitotic cell cycle mus20902448 mitotic metaphase mus20902448 nucleus | embryonic stage 4 mus2092735 mus209B1 nurse cell | ectopic mus2092735 mus209B1 ovariole mus2092735 mus209B1 ovary mus2092735 mus209B1 posterior scutellar bristle, with Scer\GAL4sca-109-68 mus209KK108382 prothoracic leg mus209B1 sex comb | ectopic mus209B1 spindle mus20902448
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of mus209 Class Mutagen Stocks Known lesion mus209k00704 P-element activity 3 -- mus20902448 P-element activity 2 -- mus209EY09082 P-element activity 2 -- mus20904 1 Yes mus209k00501 P-element activity 1 -- mus209k05317 P-element activity 1 -- mus209k06130 P-element activity 1 -- mus20902697 P-element activity 0 -- mus20906652 P-element activity 0 -- mus209157 ethyl methanesulfonate 0 Yes mus2091991 ethyl methanesulfonate 0 -- mus2092735 ethyl methanesulfonate 0 Yes mus20936 ethyl methanesulfonate 0 Yes mus209775 ethyl methanesulfonate 0 Yes mus209B1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes mus209D-1368 ethyl methanesulfonate 0 Yes mus209D-292 ethyl methanesulfonate 0 -- mus209D-91 ethyl methanesulfonate 0 -- mus209D-932 ethyl methanesulfonate 0 -- mus209DR15-r1 Delta2-3 0 -- mus209DR15-r2 Delta2-3 0 -- mus209DR15-r3 Delta2-3 0 -- mus209DR15-r4 Delta2-3 0 -- mus209DR15-r5 Delta2-3 0 -- mus209DR15-r6 Delta2-3 0 -- mus209DR15 P-element activity 0 Yes mus209k05313 P-element activity 0 -- mus209k05328 P-element activity 0 -- mus209k10504 P-element activity 0 -- mus209s1534 P-element activity 0 -- mus209unspecified 0 --
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mus209 Class Mutagen Stocks Known lesion mus209GD4205 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mus209HMS00634 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mus209KK108382 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mus209ΔNhe.T:Avic\GFP in vitro construct - coding region fusion 1 Yes mus209+t5.2 in vitro construct - genomic fragment 0 Yes mus209+t5 in vitro construct - genomic fragment 0 Yes mus209+t6.5 in vitro construct - genomic fragment 0 Yes mus209+t7 in vitro construct - genomic fragment 0 Yes mus209+tTa in vitro construct - genomic fragment 0 Yes mus209G3.8RKO in vitro construct - genomic fragment 0 Yes mus209T:Avic\GFP in vitro construct - coding region fusion 0 -- mus209tΔsI in vitro construct - site directed mutagenesis 0 Yes mus209tΔsII in vitro construct - site directed mutagenesis 0 Yes mus209tΔsIsII in vitro construct - site directed mutagenesis 0 Yes mus209ΔNhe.ΔsI.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes mus209ΔNhe.ΔsI.ΔsII.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes mus209ΔNhe.ΔsII.T:Avic\GFP in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)017 (Spradling et al., 1999, Shellenbarger and Duttagupta, 1978, BDGP Project Members, 1994-1999, Henderson et al., 1994) Df(2R)173 (Thacker et al., 2003, Shellenbarger and Duttagupta, 1978, Axton et al., 1994, Henderson et al., 1994) Df(2R)Exel7162 (Ryder, 2004.4.26)
Not disrupted in	Df(1)v-L15 (Schalet, 1986) Df(2R)exu1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{5'-86DPCNAlacZ} No P{5'-86P3NlacZ} No P{5'-86P3RlacZ} No P{5'-86P3SphIlacZ} No P{5'-98DPCNAlacZ} No P{5'-119DPCNAlacZ} No P{5'-119mutIDPCNAlacZ} No P{5'-119mutIn8(-81)DPCNAlacZ} No P{5'-119Δ2(-81-82)DPCNAlacZ} No P{5'-119Δ6(-77-82)DPCNAlacZ} No P{5'-149DPCNAlacZ.mutβ} No P{5'-149DPCNAlacZ.mutδ} No P{5'-149DPCNAlacZ} No P{5'-168DFΔ(-81~-98)} No P{5'-168DPCNAlacZ} No P{5'-168EsFmutI&IIDPCNAlacZW8HS} No P{5'-168EsFmutIDPCNAlacZW8HS} No P{5'-168EsFmutIIDPCNAlacZW8HS} No P{5'-168mutIDPCNAlacZ} No P{5'-168TATAlacZ} No P{5'-168Δ6(-77-82)DPCNAlacZ} No P{5'-607DPCNAlacZ} No P{ClaI-} No P{mutA} No P{mutB} No P{mutC} No P{mutD} No P{mutE} No P{mutF} No P{mutG} No P{mutH} No P{mutΔ1(-96)} No P{mutΔ1(-98)} No P{mutΔ3} No P{mutΔ4} No P{mutΔ6} No P{mutΔ18} No P{P3R-TATAlacZ} No UAS construct P{GD4205} NA P{KK108382} NA P{TRiP.HMS00634} NA characterization construct P{5kbEcoRI} NA P{7kbBamHI} NA P{B6.5} NA P{E5.2} NA P{G3.8} NA P{G3.8RKO} NA P{mus209.Nuhe.Δ1::GFP} NA P{mus209.Nuhe.Δ1.Δ2::GFP} NA P{mus209.Nuhe.ΔsII::GFP} NA P{mus209.ΔNhe::GFP} NA P{mus209.ΔsI} NA P{mus209.ΔsII} NA P{mus209.ΔsIsII} NA P{mus209+.T} NA P{mus209-GFP.D} NA P{mus209-GFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}mus209EY09082 NA insertion of enhancer trap P{lacW}l(2)SH0476SH0476 No P{lacW}mus209k00501 No P{lacW}mus209k00704 No P{lacW}mus209k05313 No P{lacW}mus209k05317 No P{lacW}mus209k05328 No P{lacW}mus209k06130 No P{lacW}mus209k10504 No P{lacW}mus209s1534 No P{PZ}mus20902448 No P{PZ}mus20902697 No P{PZ}mus20906652 No miscellaneous insertions P{Ddc1/4}mus209DR15 NA P{UASp-YFP.CG9807.D67L}mus20904 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) DNA replication inferred from mutant phenotype (Pflumm and Botchan, 2001) mitotic spindle organization inferred from mutant phenotype (Pflumm and Botchan, 2001) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR000730, InterPro:IPR022648, InterPro:IPR022649 (FlyBase Curators et al., 2004-) DNA polymerase processivity factor activity inferred from electronic annotation with InterPro:IPR000730, InterPro:IPR022648, InterPro:IPR022649 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
DNA-dependent DNA replication traceable author statement (Sekelsky et al., 1998) DNA replication traceable author statement (Lee and Orr-Weaver, 2003) eggshell chorion gene amplification traceable author statement (Lee and Orr-Weaver, 2003) leading strand elongation non-traceable author statement (Swiss-Prot Project Members, 1990.11.1) mismatch repair traceable author statement (Sekelsky et al., 1998) nucleotide-excision repair traceable author statement (Sekelsky et al., 1998) regulation of DNA replication inferred from electronic annotation with InterPro:IPR000730, InterPro:IPR022648, InterPro:IPR022649 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
PCNA complex inferred from sequence or structural similarity with UniProtKB:O16852 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mus209 allele Gene References mus209B1 crm (Yamamoto et al., 1997) unspecified l(2)56Fb   pzg (Kugler and Nagel, 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62946 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005655 DroID - A comprehensive database of gene and protein interactions. • FBgn0005655 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37290
Orthologs
Genome-wide drosophilid orthologs	Dana\mus209 Dere\mus209 Dgri\GH22744 Dmoj\GI18526 Dper\GL17573 Dpse\GA21602 Dsec\mus209 Dsim\mus209 Dvir\mus209 Dwil\mus209 Dyak\mus209
Curated drosophilid orthologs	Dana\mus209   Dere\mus209   Dfun\mus209   Dhyd\mus209   Dmau\mus209   Dmer\mus209   Dpse\GA21602   Dsal\mus209   Dsec\mus209   Dsim\mus209   Dvir\mus209   Dwil\mus209   Dyak\mus209
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL012545-PA Aedes aegypti (mosquito) AGAP010220-PA Anopheles gambiae (mosquito) XP_001122985.1 Apis mellifera (honey bee) XP_001947333.1 Acyrthosiphon pisum (pea aphid) At1g07370.1 Arabidopsis thaliana (wall cress) At2g29570.1 Arabidopsis thaliana (wall cress) 92516 Batrachochytrium dendrobatidis (chytrid fungus) 115812 Branchiostoma floridae (lancelet) 268776 Branchiostoma floridae (lancelet) XP_001898504.1 Brugia malayi (roundworm nematode) BGIBMGA010906-PA Bombyx mori (silk worm) ENSBTAP00000007967 Bos taurus (bovine) CAL0003616 Candida albicans (a form of yeast) CN12624 Caenorhabditis brenneri (small nematode) CBP36454 Caenorhabditis briggsae (nematode) CE37726 Caenorhabditis elegans (worm) ENSCAFP00000009045 Canis familiaris (dog) CAGL0D01716g Candida glabrata (haploid yeast) Chro.80254 Cryptosporidium hominis (obligate parasite) ENSCINP00000004842 Ciona intestinalis (sea squirt) CMS101C Cyanidioschyzon merolae (red alga) cgd8_2150 Cryptosporidium parvum (protozoan parasite) CPIJ009046 Culex pipens (mosquito) ENSCPOP00000008297 Cavia porcellus (guinea pig) 140580 Chlamidomonas reinhardtii (green alga) RP27044 Caenorhabditis remanei (nematode) 161800 Capitella spl (polychaete worm) DDB0231779 Dictyostelium discoideum (amoeba) DEHA2D17842g Debaryomyces Hansenii (yeast) 309373 Daphnia pulex (daphnia) ENSDARP00000070780 Danio rerio (zebra fish) ENSECAP00000010854 Equus caballus (horse) ENSGACP00000007613 Gymnopilus aculeatus (mushroom) ENSGALP00000040305 Gallus gallus (chicken) GL50803_6564 Giardia lamblia (flagellated protozoan) 185039 Hypsipyla robusta (cedar shoot borer) ENSP00000368458 Homo sapiens (human) ISCW022029-PA Ixodes scapularis (deer tick) KLLA0B12078g Kluyveromyces lactis (yeast) 185272 Lottia gigantea (owl limpet) LmjF15.1450 Leishmania major (virus) 37444 Monocosta brevicollis (choanoflagellate) ENSMODP00000014595 Monodelphis domestica (gray opossum) ENSMMUP00000017436 Macaca mulatta (rhesus monkey) ENSMUSP00000028817 Mus musculus (house mouse) XP_001605199.1 Nasonia vitripennis (wasp) ENSOANP00000025275 Ornithorynchus anatinus (platypus) ENSORLP00000003669 Oryzias latipes (japanese killifish) LOC_Os02g56130.1 Oryza sativa (asian rice) 8514 Ostreococcus tauri (green alga) PF13_0328 Plasmodium falciparum (protozoal parasite) PHUM003641-PA Pediculus humanus (human body louse) PP02942 Pristionchus pacificus (nematode) 162696 Physcomitrella patens (moss) ENSPPYP00000012059 Pongo pygmaeus (orangutan) 71844 Phytophthora ramorum (sudden oak death pathogen) 108664 Phytophthora sojae (root rot pathogen) 706048 Populus trichocarpa (black cottonwood) ENSPTRP00000022674 Pan troglodytes (chimpanzee) PVX_115055 Plasmodium vivax (protozoal parasite) ENSRNOP00000028887 Rattus norvegicus (norway rat) 4758380 Sorghum bicolor (sorghum) YBR088C Saccharomyces cerevisiae (budding yeast) Smp_046500.1 Schistosoma mansoni (trematode parasite) SPBC16D10.09 Schizosaccharomyces pombe (fission yeast) XP_001196966.1 Strongylocentrotus purpuratus (purple sea urchin) 50695 Trichoplax adhaerens (metazoa) TA04590 Theileria annulata (apicomplexan parasite) XP_975196.1 Tribolium castaneum (red flour beetle) Tc00.1047053507913.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508277.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018432 Tetraodon nigroviridis (green spotted pufferfish) TP03_0445 Theileria parva (parasitic protozoan) 261635 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036585 Takifugu rubripes (pufferfish Takifugu) 3794.m00183 Tetrahymena thermophila (ciliate protozoa) 90019.m00246 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000017963 Xenopus tropicalis (frog) YALI0D10571g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13828 LH22330 ISCW022029 FBgn0064248 FBgn0064267 FBgn0064310 FBgn0064355 FBgn0064374 JGI_V11_309373 FBgn0081588 FBgn0155176 FBgn0141265 FBgn0130201 FBgn0064602 FBgn0064748 CPIJ009046 BGIBMGA010906 ACYPI003821 GB12209 AGAP010220 AAEL012545 PB22882 PHUM372290 GLEAN_08874
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	25749 y1 w*; P{mus209.ΔNhe::GFP}T110 11192 cn1 P{PZ}mus20902448/CyO; ry506 10361 y1 w67c23; P{lacW}mus209k00704/CyO 19948 y1 w67c23; P{EPgy2}mus209EY09082/CyO
Kyoto	108866 cn1 P{PZ}mus20902448/CyO; ry506 108852 y1 w67c23; P{lacW}mus209k00704/CyO 102156 y1 w67c23 ; P{lacW}mus209k00501 / CyO 102359 y1 w67c23 ; P{lacW}mus209k05317 / CyO 102447 y1 w67c23 ; P{lacW}mus209k06130 / CyO
VDRC	v108384 P{KK108382}VIE-260B v51253 w1118; P{GD4205}v51253 v51252 w1118; P{GD4205}v51252/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR23F24 BACR48L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 266 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD45889
Other clones	DPiM_LD45889 yak-em_mus209
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM15340 GM19971 GM21128 GM27264 LD04695 LD14762 LD16272 LD32042 LD39980 LD41830 LD44807 LP16027 RE04529 RE17367 RE17866 RE28606 RE35572 RE43546 RE44120 RE46707 RE68750 SD08066 SD13417 SD14688 SD21448 SD25045 SD26056 SD26633 SD28240
Other clones	15429 17062 18372 161511 CK01.167C.H12 Dmel_dig_003950_0690_3323 Dmel_dig_005356_0690_1770 Dmel_dig_009432_0648_1113 Dmel_dig_015614_0691_0962 Dmel_neb_009512_0608_3414 Dmel_neb_011700_0824_1887 Dmel_neb_015005_0323_1537 EK103162 EK265338 FGM101G02 FGM232E12 IP02751 RP003012238 RP003014982 RP003017704 RP003019864 RP003028614 RP003032537 RP003046742 RP003051773 RP003053269 RP003055930 RP003059746 RP003062624 RP003066566 RP003071436 RP003074600 RP003077555 RP003082298 RP003086500 RP003088478 RP003088682 RP003088920 RP003090569 RP003091143 RP003094360 RP003099118 RP003103324 RP003103440 RP003106756 RP003109142 RP003109510 RP003113417 RP003117728 RP003118839 RP003120534 RP003125504 RP003125570 RP003127587 RP003132108 RP003132362 RP003133012 RP003134485 RP003137157 RP003140240 RP003141621 RP003148649 RP003150046 RP003152978 RP003157728 RP003159551 RP003161410 RP003163769 RP003164337 RP003164471 RP003165076 RP003165998 RP003169771 RP003169976 RP003182251 RP003183724 RP003185151 RP003189581 RP003193709 RP003194690 RP003195594 RP003200325 RP003201029 RP003202762 RP003209632 RP003211418 RP003212126 RP003213347 RP003217999 RP003221144 RP003226281 RP003228624 RP003229553 RP003229949 RP003230670 RP003234624 RP003235352 RP003236033 RP003241062 RP003245404 RP003249284 RP003249934 RP003253598 RP003256650 RP003256867 RP003256962 RP003268424 RP003269558 RP003274075 RP003275444 RP003276802 RP003277188 RP003285155 RP003288641 RP003293762 RP003296252 RP003298853 RP003303862 RP003304335 RP003308088 RP003311813 RP003314391 RP003314577 RP003318497 RP003320317 RP003322638 RP003325897 RP003325977 RP003334777 RP003335304 RP003336971 RP003337037 RP003343614 RP003343853 RP003346926 RP003348274 RP003351807 RP003351831 RP003355556 RP003357275 RP003359222 RP003362005 RP003363011 RP003364119 RP003370212 RP003372993 RP003373842 RP003379041 RP003391956 RP003396010 RP003398132 RP003398632 RP003405087 RP003408422 RP003411750 RP003418063 RP003426333 RP003429077 RP003429195 RP003429362 RP003431899 RP003432379 RP003437824 RP003442177 RP003448384 RP003449104 RP003450479 RP003451003 RP003459022 RP003459393 RP003467018 RP003470510 RP003471540 RP003477743 RP003487715 RP003489971 RP003492231 RP003493332 RP003495546 RP003502958 RP003503957 RP003507242 RP003513465 RP003516311 RP003517532 RP003519942 RP003524175 RP003524922 RP003527955 RP003531022 RP003535438 RP003538111 RP003545406 RP003545879 RP003546139 RP003549010 RP003551025 RP003553410 RP003555256 RP003563609 RP003564322 RP003564387 RP003564942 RP003572108 RP003573249 RP003577501 RP003577658 RP003578876 RP003582237 RP003584344 RP003591434 RP003593441 RP003594209 RP003596171 RP003600160 RP003606197 RP003606947 RP003614077 RP003620474 RP003620918 RP003624968 RP003631980 RP003640586 RP003642275 RP003645814 RP003649989 RP003656183 RP003659780 RP003663185 RP003664301 RP003669579 RP003672508 RP003672708 RP003678718
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005655 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37290
Antibody Information
	polyclonal (Ruike et al., 2006)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mus209 CG9193 (Milshina, 1999.11)
Source for database merge of	Source for merge of: mus209 l(2)02448 (Spradling et al., 1999)
Additional comments	FlyBase curator comment: the insertion in the "f03331" Exelixis line (PBac{WH}pluf03331) was originally assigned to the mus209 gene in FBrf0179797, resulting in the "mus209f03331" (FBal0158909) allele. However, FBrf0184340 shows that the insertion is actually within plu. (Bloomington Drosophila Stock Center, 2004.11.6) Four complementation groups within Df(2R)017 but not Df(2R)173 (not further described) plus five sites uncovered by both deficiencies, which are separable by complementation analysis, but arbitrarily considered to represent three gene loci, two of which have complementing alleles, and the third of which interacts in trans with the other two. Except for the fact that l(2)56Fa maps to the left of M(2)56F and the inference that l(2)56Fb lies between them, nothing known of order of loci.
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for mus209 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells. (Kleino et al., 2005) Gene is involved in post-replication translesion synthesis repair. (de Buendia, 1998) mus209 function is indispensable for the repair of DNA double-strand breaks. (Henderson and Glover, 1998) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) The genetic interaction between crm and mus209 highlight possible interactions between Pc-group mediated gene silencing and DNA replication. (Yamamoto et al., 1997) Several elements of the mus209 promoter play roles during development. The DRE (DNA replication-related element) is analysed and URE (upstream regulatory element) is identified and shown to also play an essential role. (Yamaguchi et al., 1996) DRE (DNA replication-related element), consisting of an 8bp palindrome, TATCGATA, is responsible for activating the mus209 promoter in both cultured cells and in transgenic flies. (Matsukage et al., 1995) Analysis of mus209-Ecol\lacZ promoter fusions suggests that the mus209 promoter region is practically sufficient for its proper expression and that the homeodomain protein binding region functions as a silencer when tor is activated ectopically. (Yamaguchi et al., 1995) The expression of mus209 during embryogenesis and in Kc cells has been studied. The prolonged halflife of the mus209 protein in stg mutant embryos suggests involvement of phosphorylation or dephosphorylation of some proteins in disassembly of the DNA replication enzyme complex. (Yamaguchi et al., 1995) A 10bp sequence including the 8bp palindromic sequence is necessary for binding to DNA replication-related element binding factor (DREF). In Kc cells the 8bp palindromic sequence is necessary and sufficient for the DRE function. In living flies the 8bp is important for the DRE function buts its requirement appears to be less stringent than that in cultured cells. (Yamaguchi et al., 1995) E2f sites are present within the mus209 promoter and are required for mus209 promoter function throughout development. (Yamaguchi et al., 1995) Expression pattern and subcellular distribution of the protein during development is studied using antibodies. (Yamaguchi et al., 1995) The coordinate program of expression of S phase genes (DNApol-α180, mus209, RnrL and RnrS) can be induced by CycE expression, but is not disrupted in stg mutants and is therefore not a secondary consequence of cell cycle progression. (Duronio and O'Farrell, 1994) The vital function of mus209 is required in virtually all stages of fly development. mus209 has a DNA repair related function which may be distinct from its vital function and mutations suppress position-effect variegation. (Henderson et al., 1994) mus209 is negatively regulated by zen protein. This repression is mediated by the DRE (DNA replication-related element) sites in the mus209 promoter. The amount of Dref is reduced in transfected Kc cells expressing zen, suggesting that zen represses expression of DNA replication-related genes by reducing the amount of Dref. (Hirose et al., 1994) DNApol-α and mus209 products share DRE, an 8bp palindrome required for high expression. (Hirose et al., 1993) mus209 protein distribution during the first 13 nuclear division cycles of embryogenesis has been studied. (Yamaguchi et al., 1991) The region of mus209 5' flanking sequences required for promoter activity has been mapped to a 192bp region (-168 to +24bp relative to the transcription start site) using a series of mus209-Ecol\CAT reporter constructs. zen represses transcription from the mus209 promoter of mus209-Ecol\CAT reporter constructs. (Yamaguchi et al., 1991) mus209 protein has been purified and characterised. (Ng et al., 1990) mus209 has been cloned, sequenced and its RNA expression pattern analysed. In vitro DNA footprinting analysis shows that eve and zen can bind to sites in the mus209 5' flanking region. (Yamaguchi et al., 1990) One of a series of mostly recessive lethals recovered based on their lethality in combination with Df(2R)173 (cytology normal) and Df(2R)017 (Shellenbarger and Duttagupta, 1978; Duttagupta and Shellenbarger, 1980).   Recessive lethal; no phenotype in heterozygote, except when heterozygous to l(2)56Fb in which case short thin bristles are observed.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057557 NM_206182 RefSeq (Proteins) • NP_476905 NP_995904 DDBJ / EMBL / GenBank • AAA28746 AAF57493 AAM52709 AAO17673 AAS64796 AC004321 AI513872 AQ073269 AW943811 AY122197 AY167137 CL632183 M33950 Entrez Gene - A searchable database of RefSeq genes. • 37290 UniProtKB/Swiss-Prot • P17917 UniProtKB/TrEMBL • Q868I9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proliferating cell nuclear antigen, PCNA (IPR000730) Proliferating cell nuclear antigen, PCNA, N-terminal (IPR022648) Proliferating cell nuclear antigen, PCNA, C-terminal (IPR022649) Proliferating cell nuclear antigen, PCNA, conserved site (IPR022659)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62946 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005655 DroID - A comprehensive database of gene and protein interactions. • FBgn0005655 DRSC - Results from RNAi screens. • FBgn0005655 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005655 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9193-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005655 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37290 InParanoid A subset of ortholog calls from InParanoid. • AAEL012545-PA Aedes aegypti (mosquito) AGAP010220-PA Anopheles gambiae (mosquito) XP_001122985.1 Apis mellifera (honey bee) XP_001947333.1 Acyrthosiphon pisum (pea aphid) At1g07370.1 Arabidopsis thaliana (wall cress) At2g29570.1 Arabidopsis thaliana (wall cress) 92516 Batrachochytrium dendrobatidis (chytrid fungus) 115812 Branchiostoma floridae (lancelet) 268776 Branchiostoma floridae (lancelet) XP_001898504.1 Brugia malayi (roundworm nematode) BGIBMGA010906-PA Bombyx mori (silk worm) ENSBTAP00000007967 Bos taurus (bovine) CAL0003616 Candida albicans (a form of yeast) CN12624 Caenorhabditis brenneri (small nematode) CBP36454 Caenorhabditis briggsae (nematode) CE37726 Caenorhabditis elegans (worm) ENSCAFP00000009045 Canis familiaris (dog) CAGL0D01716g Candida glabrata (haploid yeast) Chro.80254 Cryptosporidium hominis (obligate parasite) ENSCINP00000004842 Ciona intestinalis (sea squirt) CMS101C Cyanidioschyzon merolae (red alga) cgd8_2150 Cryptosporidium parvum (protozoan parasite) CPIJ009046 Culex pipens (mosquito) ENSCPOP00000008297 Cavia porcellus (guinea pig) 140580 Chlamidomonas reinhardtii (green alga) RP27044 Caenorhabditis remanei (nematode) 161800 Capitella spl (polychaete worm) DDB0231779 Dictyostelium discoideum (amoeba) DEHA2D17842g Debaryomyces Hansenii (yeast) 309373 Daphnia pulex (daphnia) ENSDARP00000070780 Danio rerio (zebra fish) ENSECAP00000010854 Equus caballus (horse) ENSGACP00000007613 Gymnopilus aculeatus (mushroom) ENSGALP00000040305 Gallus gallus (chicken) GL50803_6564 Giardia lamblia (flagellated protozoan) 185039 Hypsipyla robusta (cedar shoot borer) ENSP00000368458 Homo sapiens (human) ISCW022029-PA Ixodes scapularis (deer tick) KLLA0B12078g Kluyveromyces lactis (yeast) 185272 Lottia gigantea (owl limpet) LmjF15.1450 Leishmania major (virus) 37444 Monocosta brevicollis (choanoflagellate) ENSMODP00000014595 Monodelphis domestica (gray opossum) ENSMMUP00000017436 Macaca mulatta (rhesus monkey) ENSMUSP00000028817 Mus musculus (house mouse) XP_001605199.1 Nasonia vitripennis (wasp) ENSOANP00000025275 Ornithorynchus anatinus (platypus) ENSORLP00000003669 Oryzias latipes (japanese killifish) LOC_Os02g56130.1 Oryza sativa (asian rice) 8514 Ostreococcus tauri (green alga) PF13_0328 Plasmodium falciparum (protozoal parasite) PHUM003641-PA Pediculus humanus (human body louse) PP02942 Pristionchus pacificus (nematode) 162696 Physcomitrella patens (moss) ENSPPYP00000012059 Pongo pygmaeus (orangutan) 71844 Phytophthora ramorum (sudden oak death pathogen) 108664 Phytophthora sojae (root rot pathogen) 706048 Populus trichocarpa (black cottonwood) ENSPTRP00000022674 Pan troglodytes (chimpanzee) PVX_115055 Plasmodium vivax (protozoal parasite) ENSRNOP00000028887 Rattus norvegicus (norway rat) 4758380 Sorghum bicolor (sorghum) YBR088C Saccharomyces cerevisiae (budding yeast) Smp_046500.1 Schistosoma mansoni (trematode parasite) SPBC16D10.09 Schizosaccharomyces pombe (fission yeast) XP_001196966.1 Strongylocentrotus purpuratus (purple sea urchin) 50695 Trichoplax adhaerens (metazoa) TA04590 Theileria annulata (apicomplexan parasite) XP_975196.1 Tribolium castaneum (red flour beetle) Tc00.1047053507913.30 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053508277.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018432 Tetraodon nigroviridis (green spotted pufferfish) TP03_0445 Theileria parva (parasitic protozoan) 261635 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036585 Takifugu rubripes (pufferfish Takifugu) 3794.m00183 Tetrahymena thermophila (ciliate protozoa) 90019.m00246 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000017963 Xenopus tropicalis (frog) YALI0D10571g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/pcna1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37290 modMine - Data generated by the modENCODE project. • FBgn0005655 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13828 LH22330 ISCW022029 FBgn0064248 FBgn0064267 FBgn0064310 FBgn0064355 FBgn0064374 JGI_V11_309373 FBgn0081588 FBgn0155176 FBgn0141265 FBgn0130201 FBgn0064602 FBgn0064748 CPIJ009046 BGIBMGA010906 ACYPI003821 GB12209 AGAP010220 AAEL012545 PB22882 PHUM372290 GLEAN_08874 REDfly - A database of transcriptional regulatory elements. • FBgn0005655
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	53/13 (Roch et al., 1998) CG9193 (Keleman et al., 2009.8.5, Wittkopp et al., 2008, Hughes et al., 2008, Ni et al., 2010.12.1) DmPCNA (Takeuchi et al., 2004, Dusenbery and Smith, 1996) dPCNA (Seto et al., 2006, Otsuki et al., 2004, Suzuki et al., 2009) l(2)56F   l(2)56Fa   l(2)02448 (McKim and Hayashi-Hagihara, 1998, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(2)s1534   Mus209 (Landry et al., 2005) mus209 (Liu et al., 2005, Volkova et al., 2004, Cayirlioglu et al., 2003, Zhang et al., 2007, Kugler and Nagel, 2007, Wei and Rong, 2007, Nelson et al., 2005, Duronio, 2008.10.27, Somma et al., 2008, Aerts et al., 2009, Wittkopp et al., 2008, Morris et al., 2006, Zhou et al., 2008, Ruike et al., 2006, Lopez et al., 2005, Mishra et al., 2011, Neumüller et al., 2011) MUS209 (Filion et al., 2010) pcna (Korenjak et al., 2004, Claycomb and Orr-Weaver, 2005, Lee and Orr-Weaver, 2003, Hayashi and Yamaguchi, 1999, Buttitta et al., 2007, Siegrist et al., 2010, Kawamori and Yamaguchi, 2011) PCNA (Claycomb et al., 2002, Takata et al., 2004, Zraly et al., 2004, Zhai et al., 2004, Shibutani et al., 2005, Davidson, 2003, Duman-Scheel et al., 2004, Swanhart et al., 2004, Dimova et al., 2003, Chen et al., 2003, Thacker et al., 2003, Venkatesan et al., 2003, Renault et al., 2003, Frolov et al., 2003, Ahmad and Henikoff, 2002, Hochheimer and Tjian, 2003, Renault and Axton, 2003, Takata et al., 2002, Gerbi and Bielinsky, 2002, Loppin et al., 2001, Bosco et al., 2001, Royzman et al., 2002, Hochheimer et al., 2002, Thacker et al., 2003, Pielage et al., 2002, Wilanowski et al., 2002, Duman-Scheel et al., 2002, Xin et al., 2002, Frolov et al., 2001, Takata et al., 2001, Mello and Almouzni, 2001, Pflumm and Botchan, 2001, Fisher et al., 2001, Park et al., 2001, Whittaker et al., 2000, Cho et al., 2000, Du, 2000, Hayashi et al., 1999, Asano and Wharton, 1999, Royzman et al., 1999, Royzman and Orr-Weaver, 1998, Whittaker et al., 1999, Tsurimoto, 1998, Du and Dyson, 1999, Ohno et al., 1998, Warbrick et al., 1995, Sawado et al., 1998, Dyson, 1998, Warbrick et al., 1998, de Buendia, 1998, Jaffe and Jongens, 1998, Henderson and Glover, 1998, Duronio et al., 1998, Wilkins and Lis, 1997, Royzman et al., 1997, Mozzherin et al., 1997, Royzman et al., 1997, Frenz and Glover, 1996, Duronio et al., 1996, Takahashi et al., 1996, Yamaguchi et al., 1995, Leclerc et al., 1996, Hirose et al., 1996, Royzman et al., 1996, Matsukage et al., 1995, Yamaguchi et al., 1995, Yamaguchi et al., 1995, Duronio and O'Farrell, 1995, Duronio et al., 1995, Yamaguchi et al., 1995, Yamaguchi et al., 1995, Duronio and O'Farrell, 1994, Hirose et al., 1994, Axton et al., 1994, Smith et al., 1993, Foe et al., 1993, Ng et al., 1993, Yamaguchi et al., 1991, Yamaguchi et al., 1991, Whalen et al., 1991, Yamaguchi et al., 1990, Ng et al., 1990, Weng et al., 2003, Ji et al., 2006, Baena-Lopez and Garcia-Bellido, 2006, Bazigou et al., 2007, Tsuda et al., 2006, Herr et al., 2007, Wallace and Orr-Weaver, 2005, Otsuki et al., 2004, Cayirlioglu et al., 2003, Rodrigues-Martins et al., 2007, Swanhart et al., 2007, Ullah et al., 2007, Taylor-Harding et al., 2004, Frolov et al., 2005, Hyun et al., 2005, Fuss et al., 2001, Ambrus et al., 2007, Somma et al., 2008, Lu et al., 2007, Park et al., 2007, Zielke et al., 2008, Easwaran et al., 2007, Mitchell et al., 2008, Escudero and Freeman, 2007, Ida et al., 2009, Aerts et al., 2009, Hirose et al., 2002, Peng and Karpen, 2009, Nie et al., 2009, Smith-Bolton et al., 2009, Choi et al., 2008, Insco et al., 2009, Ambrus et al., 2009, McCleland et al., 2009, Sackton et al., 2009, Morris et al., 2006, Insco et al., 2009, Beck et al., 2010, Flannery et al., 2010, Taniue et al., 2010, Buttitta et al., 2010, Gou et al., 2010, Reddy et al., 2010, Kwon et al., 2004, Kawamori and Yamaguchi, 2011, Hsieh et al., 2010) Pcna (Pflumm, 2002, Cayirlioglu et al., 2001, Adams et al., 2000, Hung et al., 1999, Maroni, 1994, Hirose et al., 1993, Isogai et al., 2007, Shibutani et al., 2008) PCNA/mus209 (Li and White, 2003)
Name Synonym	mutagen-sensitive 209 (Nelson et al., 2005) proliferating cell nuclear antigen (Yamaguchi et al., 1991, Baena-Lopez and Garcia-Bellido, 2006, Buttitta et al., 2007, Buttitta et al., 2010, Kwon et al., 2004) Proliferating-cell-nuclear-antigen   proliferating-cell nuclear antigen (Gou et al., 2010)
Secondary FlyBase IDs
	FBgn0002895 FBgn0003045 FBgn0004700 FBgn0010513 FBgn0010677
References ( 221 )
Generate a list of	All references relating to this gene ( 221 )
List References by type	Research paper  ( 162 ) Supplementary material  ( 8 ) Review  ( 19 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 13 ) FlyBase analysis  ( 2 ) Computer file  ( 3 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 14 )
	Kawamori and Yamaguchi, 2011, Cell Struct. Funct. 36(1): 103--119 DREF is Critical for Drosophila Bristle Development by Regulating Endoreplication in Shaft Cells. [FBrf0213809] Mishra et al., 2011, Mutat. Res. 722(1): 44--51 Tracing the tracks of genotoxicity by trivalent and hexavalent chromium in Drosophila melanogaster. [FBrf0213784] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Sayal et al., 2011, Fly 5(1): 47--52 Optimization of reporter gene architecture for quantitative measurements of gene expression in the Drosophila embryo. [FBrf0213005] Beck et al., 2010, Dev. Biol. 339(2): 320--328 Cell cycle defects in polyhomeotic mutants are caused by abrogation of the DNA damage checkpoint. [FBrf0210114] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Buttitta et al., 2010, J. Cell Biol. 189(6): 981--996 A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. [FBrf0211029] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Flannery et al., 2010, Dev. Neurobiol. 70(7): 473--484 Induction of cellular growth by the axon guidance regulators Netrin A and Semaphorin-1a. [FBrf0210827] Gou et al., 2010, PLoS ONE 5(5): e10581 SETDB1 Is Involved in Postembryonic DNA Methylation and Gene Silencing in Drosophila. [FBrf0210815] Hsieh et al., 2010, PLoS Genet. 6(8): Tuberous Sclerosis Complex 1 Regulates dE2F1 Expression during Development and Cooperates with RBF1 to Control Proliferation and Survival. [FBrf0211700] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Siegrist et al., 2010, Curr. Biol. 20(7): 643--648 Inactivation of both foxo and reaper promotes long-term adult neurogenesis in Drosophila. [FBrf0210555] Taniue et al., 2010, Development 137(10): 1755--1764 Sunspot, a link between Wingless signaling and endoreplication in Drosophila. [FBrf0210642] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...