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General Information
Symbol
Dmel\PCNA
Species
D. melanogaster
Name
Proliferating cell nuclear antigen
Annotation Symbol
CG9193
Feature Type
FlyBase ID
FBgn0005655
Gene Model Status
Stock Availability
Gene Summary
Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility. (UniProt, P17917)
Contribute a Gene Snapshot for this gene.
Also Known As

mus209, l(2)02448, DmPCNA, dPCNA, mutagen-sensitive 209

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:20,261,754..20,262,883 [-]
Recombination map
2-90
RefSeq locus
NT_033778 REGION:20261754..20262883
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR000730, InterPro:IPR022648, InterPro:IPR022649
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000143422
(assigned by GO_Central )
Biological Process (13 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
involved_in DNA replication
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
(assigned by UniProt )
inferred from direct assay
(assigned by UniProt )
involved_in response to UV
inferred from direct assay
(assigned by UniProt )
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
involved_in DNA replication
traceable author statement
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000143422
(assigned by GO_Central )
involved_in mismatch repair
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000143427
(assigned by GO_Central )
traceable author statement
inferred from electronic annotation with InterPro:IPR000730, InterPro:IPR022648, InterPro:IPR022649
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000143427
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(assigned by UniProt )
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
located_in nucleus
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of PCNA complex
inferred from biological aspect of ancestor with PANTHER:PTN000143422
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the PCNA family. (P17917)
Summaries
Protein Function (UniProtKB)
Likely to be an auxiliary protein of DNA polymerase delta complex and is probably involved in the control of DNA replication and repair by increasing the polymerase's processibility.
(UniProt, P17917)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(2)56Fa
Recessive lethal; no phenotype in heterozygote, except when heterozygous to l(2)56Fb in which case short thin bristles are observed.
mus209
Larval survival hypersensitive to exposure to methyl methanesulfonate and gamma rays, but not to N-acetyl-2-aminofluorene, benzo[a]pyrene, or nitrogen mustard.
Summary (Interactive Fly)

Polymerase-delta/epsilon processivity factor - a sliding clamp that encircles DNA and tethers the DNA polymerase catalytic unit to the DNA template - Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\PCNA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0086307
1070
260
FBtr0086308
997
260
Additional Transcript Data and Comments
Reported size (kB)

1.1 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0085619
28.8
260
4.41
FBpp0089395
28.8
260
4.41
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

260 aa isoforms: PCNA-PA, PCNA-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

260 (aa); 28.8 (kD predicted)

Comments
External Data
Subunit Structure (UniProtKB)

Homotrimer (PubMed:17087725). Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Interacts with E2f (PubMed:19081076). Interacts with the catalytic subunits of two DNA polymerase complexes: DNApol-delta/DNApolD1 from the delta complex and DNApol-epsilon255/DNApol-epsilon from the epsilon complex (PubMed:17087725).

(UniProt, P17917)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\PCNA using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

A stage 13 embryo has PCNA transcripts in the nervous system, the anterior and posterior midgut, and in the hindgut and malpighian tubules. All of these tissues except the nervous system are endocycling. At stage 15, PCNA transcripts are detected in the midgut as it enters its second round of the endocycle, but transcripts have been down-regulated in the tissues that were in endocycle S phase earlier in

The highest levels of mus209 expression are seen at 0-10 hours of embryogenesis. The levels of the mus209 transcript are lower later in embryogenesis through second instar larval stages, and decrease further in third instar larval to adult stages. The high levels of mus209 transcript in adult ovaries, and in unfertilized eggs laid by virgin females suggests that the high levels of transcript in early embryogenesis are maternally contributed.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

mus209 and PolA2 proteins are detected associated with the nuclear chromatin of interphase apposed male and female pro-nuclei in newly fertilized eggs in preparation for the completion of DNA replication prior to the first zygotic division.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in chromatin
inferred from direct assay
(assigned by UniProt )
located_in cytoplasm
inferred from direct assay
(assigned by UniProt )
located_in nucleus
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\PCNA in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 33 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 22 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of PCNA
Transgenic constructs containing regulatory region of PCNA
Aberrations (Deficiencies and Duplications) ( 5 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
mitosis & nuclear chromosome
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (1)
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
13 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
15 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
9 of 9
Yes
Yes
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190E22 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915096Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0AOQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0ALP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GQ7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
7 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Homotrimer (PubMed:17087725). Forms a complex with activator 1 heteropentamer in the presence of ATP (By similarity). Interacts with E2f (PubMed:19081076). Interacts with the catalytic subunits of two DNA polymerase complexes: DNApol-delta/DNApolD1 from the delta complex and DNApol-epsilon255/DNApol-epsilon from the epsilon complex (PubMed:17087725).
    (UniProt, P17917 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-90
    Cytogenetic map
    Sequence location
    2R:20,261,754..20,262,883 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    56F11-56F11
    Limits computationally determined from genome sequence between P{lacW}Ate1k10809 and P{EP}CG10444EP951
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    56F10-56F11
    (determined by in situ hybridisation)
    56F10-56F11
    56F10--12 56F10--13 56F10--14 56F11--14
    56E-56F
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location

    2-92.3

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (20)
    Genomic Clones (9)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (201)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: mus209 CG9193

    Source for identity of: PCNA mus209

    Source for database merge of

    Source for merge of: mus209 l(2)02448

    Additional comments

    'mus209' renamed to 'PCNA' to be more informative and to reflect over-whelming usage in the literature.

    FlyBase curator comment: the insertion in the "f03331" Exelixis line (PBac{WH}pluf03331) was originally assigned to the mus209 gene in FBrf0179797, resulting in the "mus209f03331" (FBal0158909) allele. However, FBrf0184340 shows that the insertion is actually within plu.

    Four complementation groups within Df(2R)017 but not Df(2R)173 (not further described) plus five sites uncovered by both deficiencies, which are separable by complementation analysis, but arbitrarily considered to represent three gene loci, two of which have complementing alleles, and the third of which interacts in trans with the other two. Except for the fact that l(2)56Fa maps to the left of M(2)56F and the inference that l(2)56Fb lies between them, nothing known of order of loci.

    Other Comments

    DNA-protein interactions: genome-wide binding profile assayed for mus209 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a greater than three-fold increase in AttA activity in response to heat-killed E.coli after ecdysone treatment in S2 cells.

    mus209 function is indispensable for the repair of DNA double-strand breaks.

    In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

    Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

    Gene is involved in post-replication translesion synthesis repair.

    The genetic interaction between crm and mus209 highlight possible interactions between Pc-group mediated gene silencing and DNA replication.

    Several elements of the mus209 promoter play roles during development. The DRE (DNA replication-related element) is analysed and URE (upstream regulatory element) is identified and shown to also play an essential role.

    DRE (DNA replication-related element), consisting of an 8bp palindrome, TATCGATA, is responsible for activating the mus209 promoter in both cultured cells and in transgenic flies.

    Expression pattern and subcellular distribution of the protein during development is studied using antibodies.

    The expression of mus209 during embryogenesis and in Kc cells has been studied. The prolonged halflife of the mus209 protein in stg mutant embryos suggests involvement of phosphorylation or dephosphorylation of some proteins in disassembly of the DNA replication enzyme complex.

    Analysis of mus209-Ecol\lacZ promoter fusions suggests that the mus209 promoter region is practically sufficient for its proper expression and that the homeodomain protein binding region functions as a silencer when tor is activated ectopically.

    A 10bp sequence including the 8bp palindromic sequence is necessary for binding to DNA replication-related element binding factor (DREF). In Kc cells the 8bp palindromic sequence is necessary and sufficient for the DRE function. In living flies the 8bp is important for the DRE function buts its requirement appears to be less stringent than that in cultured cells.

    E2f sites are present within the mus209 promoter and are required for mus209 promoter function throughout development.

    The coordinate program of expression of S phase genes (DNApol-α180, mus209, RnrL and RnrS) can be induced by CycE expression, but is not disrupted in stg mutants and is therefore not a secondary consequence of cell cycle progression.

    The vital function of mus209 is required in virtually all stages of fly development. mus209 has a DNA repair related function which may be distinct from its vital function and mutations suppress position-effect variegation.

    mus209 is negatively regulated by zen protein. This repression is mediated by the DRE (DNA replication-related element) sites in the mus209 promoter. The amount of Dref is reduced in transfected Kc cells expressing zen, suggesting that zen represses expression of DNA replication-related genes by reducing the amount of Dref.

    DNApol-α and mus209 products share DRE, an 8bp palindrome required for high expression.

    mus209 protein distribution during the first 13 nuclear division cycles of embryogenesis has been studied.

    The region of mus209 5' flanking sequences required for promoter activity has been mapped to a 192bp region (-168 to +24bp relative to the transcription start site) using a series of mus209-Ecol\CAT reporter constructs. zen represses transcription from the mus209 promoter of mus209-Ecol\CAT reporter constructs.

    mus209 protein has been purified and characterised.

    mus209 has been cloned, sequenced and its RNA expression pattern analysed. In vitro DNA footprinting analysis shows that eve and zen can bind to sites in the mus209 5' flanking region.

    One of a series of mostly recessive lethals recovered based on their lethality in combination with Df(2R)173 (cytology normal) and Df(2R)017 (Shellenbarger and Duttagupta, 1978; Duttagupta and Shellenbarger, 1980).

    Recessive lethal; no phenotype in heterozygote, except when heterozygous to l(2)56Fb in which case short thin bristles are observed.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 65 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    EMBL-EBI Single Cell Expression Atlas
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    MARRVEL_MODEL
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (23)
    Reported As
    Symbol Synonym
    PCNA
    (Cabasso et al., 2021, Evans et al., 2021, Everetts et al., 2021, Ferguson et al., 2021, Kim et al., 2021, Zhang et al., 2021, Jin et al., 2020, Williams et al., 2020, Deneke et al., 2019, Grendler et al., 2019, Houtz et al., 2019, Hunt et al., 2019, Mouawad et al., 2019, Ariss et al., 2018, Bobkov et al., 2018, Kim et al., 2018, Kolesnikova et al., 2018, Loewen et al., 2018, Mehrotra and Deshpande, 2018, Seller and O'Farrell, 2018, Vicente et al., 2018, Romero-Pozuelo et al., 2017, Solis et al., 2017, Vo et al., 2017, Xiang et al., 2017, Zhang et al., 2017, Blythe and Wieschaus, 2016, Bradley-Gill et al., 2016, Deneke et al., 2016, Kong et al., 2016, Völker-Albert et al., 2016, Dietz et al., 2015, Elenbaas et al., 2015, Ellis et al., 2015, Molla-Herman et al., 2015, Wei et al., 2015, Yu et al., 2015, Zang et al., 2015, Frost et al., 2014, Sahashi et al., 2014, Kawamori et al., 2013, Kolesnikova et al., 2013, Merzetti et al., 2013, Ran et al., 2013, Unhavaithaya et al., 2013, Zhou and Luo, 2013, Belyaeva et al., 2012, Érdi et al., 2012, Gistelinck et al., 2012, Ji et al., 2012, Muha et al., 2012, Petruk et al., 2012, Sallé et al., 2012, Valadez-Graham et al., 2012, Weng et al., 2012, Yoshioka et al., 2012, Gibert and Karch, 2011, Kawamori and Yamaguchi, 2011, Lee et al., 2011, Vincent et al., 2011, Beck et al., 2010, Buttitta et al., 2010, Flannery et al., 2010, Gou et al., 2010, Herranz et al., 2010, Hsieh et al., 2010, Iijima et al., 2010, Maqbool et al., 2010, Reddy et al., 2010, Taniue et al., 2010, Aerts et al., 2009, Ambrus et al., 2009, Ida et al., 2009, Insco et al., 2009, Insco et al., 2009, Klapholz et al., 2009, McCleland et al., 2009, Nie et al., 2009, Peng and Karpen, 2009, Sackton et al., 2009, Smith-Bolton et al., 2009, Choi et al., 2008, Mitchell et al., 2008, Morris et al., 2008, Somma et al., 2008, Zielke et al., 2008, Ambrus et al., 2007, Bazigou et al., 2007, Easwaran et al., 2007, Escudero and Freeman, 2007, Herr et al., 2007, Ida et al., 2007, Lu et al., 2007, Park et al., 2007, Rodrigues-Martins et al., 2007, Swanhart et al., 2007, Ullah et al., 2007, Baena-Lopez and Garcia-Bellido, 2006, Ji et al., 2006, Morris et al., 2006, Tsuda et al., 2006, Frolov et al., 2005, Hyun et al., 2005, Shibutani et al., 2005, Wallace and Orr-Weaver, 2005, Duman-Scheel et al., 2004, Kwon et al., 2004, Otsuki et al., 2004, Swanhart et al., 2004, Takata et al., 2004, Taylor-Harding et al., 2004, Zhai et al., 2004, Zraly et al., 2004, Cayirlioglu et al., 2003, Chen et al., 2003, Davidson, 2003, Dimova et al., 2003, Frolov et al., 2003, Hochheimer and Tjian, 2003, Renault and Axton, 2003, Renault et al., 2003, Thacker et al., 2003, Thacker et al., 2003, Venkatesan et al., 2003, Weng et al., 2003, Ahmad and Henikoff, 2002, Claycomb et al., 2002, Duman-Scheel et al., 2002, Gerbi and Bielinsky, 2002, Hirose et al., 2002, Hochheimer et al., 2002, Pielage et al., 2002, Royzman et al., 2002, Takata et al., 2002, Wilanowski et al., 2002, Xin et al., 2002, Bosco et al., 2001, Fisher et al., 2001, Frolov et al., 2001, Fuss et al., 2001, Loppin et al., 2001, Mello and Almouzni, 2001, Park et al., 2001, Pflumm and Botchan, 2001, Takata et al., 2001, Cho et al., 2000, Du, 2000, Whittaker et al., 2000, Asano and Wharton, 1999, Du and Dyson, 1999, Hayashi et al., 1999, Royzman et al., 1999, Whittaker et al., 1999, de Buendia, 1998, Duronio et al., 1998, Dyson, 1998, Henderson and Glover, 1998, Jaffe and Jongens, 1998, Ohno et al., 1998, Royzman and Orr-Weaver, 1998, Sawado et al., 1998, Tsurimoto, 1998, Warbrick et al., 1998, Mozzherin et al., 1997, Royzman et al., 1997, Royzman et al., 1997, Wilkins and Lis, 1997, Duronio et al., 1996, Frenz and Glover, 1996, Hirose et al., 1996, Leclerc et al., 1996, Royzman et al., 1996, Takahashi et al., 1996, Duronio and O'Farrell, 1995, Duronio et al., 1995, Matsukage et al., 1995, Warbrick et al., 1995, Yamaguchi et al., 1995, Yamaguchi et al., 1995, Yamaguchi et al., 1995, Yamaguchi et al., 1995, Yamaguchi et al., 1995, Axton et al., 1994, Duronio and O'Farrell, 1994, Hirose et al., 1994, Foe et al., 1993, Ng et al., 1993, Smith et al., 1993, Whalen et al., 1991, Yamaguchi et al., 1991, Yamaguchi et al., 1991, Ng et al., 1990, Yamaguchi et al., 1990)
    PCNA/mus209
    l(2)56F
    l(2)56Fa
    l(2)s1534
    Name Synonyms
    Proliferating cell nuclear antigen
    Proliferating-cell-nuclear-antigen
    mutagen-sensitive 209
    proliferating-cell nuclear antigen
    Secondary FlyBase IDs
    • FBgn0002895
    • FBgn0003045
    • FBgn0004700
    • FBgn0010513
    • FBgn0010677
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    References (349)