FB2021_03, released June 15, 2021

Gene: Dmel\Cyp4d1

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General Information
Symbol
Dmel\Cyp4d1
Species
D. melanogaster
Name
Cytochrome P450 4d1
Annotation Symbol
CG3656
Feature Type
protein_coding_gene
FlyBase ID
FBgn0005670
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProt, P33269)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

P450, EG:87B1.1

Key Links
Genomic Location
Cytogenetic map
2D5-2D6
Sequence location
X:2,159,145..2,162,180 [-]
Recombination map
1-0.6
RefSeq locus
NC_004354 REGION:2159145..2162180
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (4 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables heme binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables iron ion binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables monooxygenase activity
inferred from biological aspect of ancestor with PANTHER:PTN002386818
(assigned by GO_Central )
(Gaudet et al., 2011)
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome P450 family. (P33269)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYTOCHROME P450 - CYP4 CLAN -
Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP4 clan includes D. melanogaster CYP4, 311-313, 316 and 318 family genes. Few CYP4 enzymes have been characterized, though some CYP4 genes are inducible by xenobiotics. (Adapted from FBrf0248421.)
Protein Function (UniProtKB)
Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
(UniProt, P33269)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Cyp4d1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cyp4d1-RA
FBtr0070428
NM_057559
1685
512
Cyp4d1-RB
FBtr0070427
NM_166932
1644
503
Additional Transcript Data and Comments
Reported size (kB)

1.7 (northern blot)

(Gandhi et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cyp4d1-PA
FBpp0070412
58.7
512
7.20
NP_476907
AAF45737
Cyp4d1-PB
FBpp0070411
57.4
503
7.09
NP_726797
AAF45736
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

511 (aa)

(Gandhi et al., 1992)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp4d1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
(Gandhi et al., 1992)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic/larval midgut

Comment: em3

(Chung et al., 2009)
third instar larval stage
embryonic/larval midgut

Comment: m1-2, m6

(Chung et al., 2009)
embryonic/larval fat body
(Chung et al., 2009)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Gandhi et al., 1992)
Additional Descriptive Data

Cyp4d1 transcripts are detected throughout development on northern blots but the highest accumulation of transcripts occurs in late larval stages.

(Gandhi et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp4d1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cyp4d1
Transgenic constructs containing regulatory region of Cyp4d1
Aberrations (Deficiencies and Duplications) ( 2 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CYP4V2
6 of 15
Yes
No
Hsap\CYP4X1
5 of 15
No
Yes
Hsap\CYP4Z1
5 of 15
No
Yes
Hsap\CYP4A22
4 of 15
No
Yes
Hsap\CYP4B1
4 of 15
No
Yes
Hsap\CYP4F2
4 of 15
No
No
Hsap\CYP4F3
4 of 15
No
No
Hsap\CYP4F8
4 of 15
No
No
Hsap\CYP4F11
4 of 15
No
Yes
Hsap\CYP4F12
4 of 15
No
No
Hsap\CYP4F22
4 of 15
No
Yes
Hsap\CYP19A1
4 of 15
No
No
Hsap\CYP4A11
3 of 15
No
No
Hsap\CYP3A4
1 of 15
No
No
1  
Hsap\CYP3A5
1 of 15
No
No
Hsap\CYP3A7
1 of 15
No
No
Hsap\CYP3A43
1 of 15
No
No
Hsap\CYP20A1
1 of 15
No
Yes
Hsap\CYP26A1
1 of 15
No
No
Hsap\CYP26B1
1 of 15
No
No
Hsap\CYP26C1
1 of 15
No
No
Hsap\CYP46A1
1 of 15
No
No
Hsap\XPNPEP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (38)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cyp4v3
6 of 15
Yes
No
Mmus\Cyp4a12a
4 of 15
No
Yes
Mmus\Cyp4a12b
4 of 15
No
Yes
Mmus\Cyp4a14
4 of 15
No
Yes
Mmus\Cyp4a31
4 of 15
No
Yes
Mmus\Cyp4a32
4 of 15
No
No
Mmus\Cyp4b1
4 of 15
No
Yes
Mmus\Cyp4f13
4 of 15
No
Yes
Mmus\Cyp4f14
4 of 15
No
No
Mmus\Cyp4f15
4 of 15
No
No
Mmus\Cyp4f18
4 of 15
No
No
Mmus\Cyp4f39
4 of 15
No
No
Mmus\Cyp4x1
4 of 15
No
Yes
Mmus\Cyp19a1
4 of 15
No
No
Mmus\Cyp4a10
3 of 15
No
Yes
Mmus\Cyp4a29
3 of 15
No
Yes
Mmus\Cyp4a30b
3 of 15
No
Yes
Mmus\Cyp4f16
3 of 15
No
No
Mmus\Cyp4f17
3 of 15
No
No
Mmus\Cyp4f37
3 of 15
No
No
Mmus\Cyp4f40
3 of 15
No
Yes
Mmus\Cyp3a57
2 of 15
No
No
Mmus\Cyp2c67
1 of 15
No
No
Mmus\Cyp2c69
1 of 15
No
No
Mmus\Cyp3a11
1 of 15
No
No
Mmus\Cyp3a13
1 of 15
No
No
Mmus\Cyp3a16
1 of 15
No
No
Mmus\Cyp3a25
1 of 15
No
No
Mmus\Cyp3a41a
1 of 15
No
No
Mmus\Cyp3a41b
1 of 15
No
No
Mmus\Cyp3a44
1 of 15
No
No
Mmus\Cyp3a59
1 of 15
No
No
Mmus\Cyp20a1
1 of 15
No
Yes
Mmus\Cyp26a1
1 of 15
No
No
Mmus\Cyp26b1
1 of 15
No
No
Mmus\Cyp26c1
1 of 15
No
No
Mmus\Cyp46a1
1 of 15
No
No
Mmus\Klkb1
1 of 15
No
No
Rattus norvegicus (Norway rat) (30)
Rnor\Cyp4v3
5 of 13
Yes
No
Rnor\Cyp4a8
4 of 13
No
Yes
Rnor\Cyp4b1
4 of 13
No
Yes
Rnor\Cyp4f1
4 of 13
No
Yes
Rnor\Cyp4f18
4 of 13
No
Yes
Rnor\Cyp4f39
4 of 13
No
Yes
Rnor\Cyp19a1
4 of 13
No
Yes
Rnor\Cyp4a2
3 of 13
No
No
Rnor\Cyp4a3
3 of 13
No
Yes
Rnor\Cyp4f4
3 of 13
No
Yes
Rnor\Cyp4f6
3 of 13
No
Yes
Rnor\Cyp4f17
3 of 13
No
Yes
Rnor\Cyp4f37
3 of 13
No
Yes
Rnor\Cyp4f40
3 of 13
No
Yes
Rnor\Cyp4a1
2 of 13
No
No
Rnor\Cyp4f5
2 of 13
No
No
Rnor\Cyp4x1
2 of 13
No
Yes
Rnor\Cyp3a18
1 of 13
No
No
Rnor\Cyp3a62
1 of 13
No
No
Rnor\Cyp3a71-ps
1 of 13
No
Yes
Rnor\Cyp20a1
1 of 13
No
Yes
Rnor\Cyp26a1
1 of 13
No
Yes
Rnor\Cyp26b1
1 of 13
No
Yes
Rnor\Cyp26c1
1 of 13
No
Yes
Rnor\Cyp46a1
1 of 13
No
No
Rnor\LOC680316
1 of 13
No
Yes
Rnor\LOC100910877
1 of 13
No
No
Rnor\LOC100912391
1 of 13
No
Yes
Rnor\LOC103692784
1 of 13
No
Yes
Rnor\Pdgfrb
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\cyp4v2
4 of 12
Yes
No
Xtro\cyp19a1
4 of 12
Yes
Yes
Xtro\cyp4b1.2
3 of 12
No
Yes
Xtro\cyp4b1
3 of 12
No
Yes
Xtro\cyp4f2
3 of 12
No
Yes
Xtro\cyp4f22
3 of 12
No
Yes
Xtro\LOC100487918
3 of 12
No
Yes
Xtro\LOC100488227
3 of 12
No
Yes
Xtro\cyp20a1
1 of 12
No
Yes
Xtro\cyp26a1
1 of 12
No
Yes
Xtro\cyp26b1
1 of 12
No
Yes
Xtro\cyp26c1
1 of 12
No
Yes
Xtro\LOC100485929
1 of 12
No
No
Xtro\LOC100487846
1 of 12
No
No
Xtro\LOC100488078
1 of 12
No
Yes
Xtro\LOC100488386
1 of 12
No
Yes
Xtro\mgc108213
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\cyp4v7
6 of 15
Yes
No
Drer\cyp4v8
6 of 15
Yes
No
Drer\cyp4f3
4 of 15
No
Yes
Drer\cyp4t8
4 of 15
No
Yes
Drer\cyp19a1a
4 of 15
No
Yes
Drer\cyp19a1b
2 of 15
No
Yes
Drer\cyp46a1.3
2 of 15
No
Yes
Drer\zgc:123299
2 of 15
No
Yes
Drer\cyp2j20
1 of 15
No
No
Drer\cyp2p7
1 of 15
No
No
Drer\cyp3a65
1 of 15
No
No
Drer\cyp3c1
1 of 15
No
No
Drer\cyp3c2
1 of 15
No
No
Drer\cyp3c3
1 of 15
No
No
Drer\cyp3c4
1 of 15
No
No
Drer\cyp20a1
1 of 15
No
Yes
Drer\cyp26a1
1 of 15
No
No
Drer\cyp26b1
1 of 15
No
Yes
Drer\cyp26c1
1 of 15
No
Yes
Drer\cyp46a1.1
1 of 15
No
No
Drer\cyp46a1.2
1 of 15
No
No
Drer\cyp46a1.4
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (29)
Cele\cyp-31A2
7 of 15
Yes
No
Cele\cyp-31A3
7 of 15
Yes
No
Cele\cyp-29A3
6 of 15
No
Yes
Cele\cyp-29A4
6 of 15
No
Yes
Cele\cyp-31A5
6 of 15
No
Yes
Cele\cyp-42A1
5 of 15
No
No
Cele\cyp-29A2
4 of 15
No
Yes
Cele\cyp-32A1
4 of 15
No
No
Cele\cyp-32B1
4 of 15
No
No
Cele\cyp-37B1
4 of 15
No
No
Cele\cyp-37A1
3 of 15
No
No
Cele\cyp-13A1
1 of 15
No
No
Cele\cyp-13A3
1 of 15
No
No
Cele\cyp-13A4
1 of 15
No
No
Cele\cyp-13A5
1 of 15
No
No
Cele\cyp-13A7
1 of 15
No
No
Cele\cyp-13A8
1 of 15
No
No
Cele\cyp-13A10
1 of 15
No
No
Cele\cyp-13A11
1 of 15
No
No
Cele\cyp-13A12
1 of 15
No
No
Cele\cyp-25A1
1 of 15
No
No
Cele\cyp-25A2
1 of 15
No
No
Cele\cyp-25A3
1 of 15
No
No
Cele\cyp-25A4
1 of 15
No
No
Cele\cyp-25A5
1 of 15
No
No
Cele\cyp-34A1
1 of 15
No
No
Cele\cyp-35A4
1 of 15
No
No
Cele\cyp-35D1
1 of 15
No
No
Cele\F23A7.3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (68)
Atha\AT5G08250
4 of 9
Yes
Yes
Atha\BAS1
4 of 9
Yes
No
Atha\CYP72A8
4 of 9
Yes
No
Atha\CYP72A9
4 of 9
Yes
No
Atha\CYP72A10
4 of 9
Yes
No
Atha\CYP72A11
4 of 9
Yes
No
Atha\CYP72A13
4 of 9
Yes
No
Atha\CYP72A14
4 of 9
Yes
No
Atha\CYP72A15
4 of 9
Yes
No
Atha\CYP86B1
4 of 9
Yes
Yes
Atha\CYP94B2
4 of 9
Yes
Yes
Atha\CYP704B1
4 of 9
Yes
Yes
Atha\CYP715A1
4 of 9
Yes
No
Atha\CYP735A1
4 of 9
Yes
No
Atha\CYP735A2
4 of 9
Yes
No
Atha\CYP72A7
3 of 9
No
No
Atha\CYP86A4
3 of 9
No
Yes
Atha\CYP86C1
3 of 9
No
Yes
Atha\CYP86C3
3 of 9
No
Yes
Atha\CYP86C4
3 of 9
No
Yes
Atha\CYP94B1
3 of 9
No
Yes
Atha\CYP94B3
3 of 9
No
Yes
Atha\CYP94D1
3 of 9
No
Yes
Atha\CYP94D2
3 of 9
No
Yes
Atha\CYP97A3
3 of 9
No
No
Atha\CYP704A1
3 of 9
No
No
Atha\CYP704A2
3 of 9
No
No
Atha\CYP709B1
3 of 9
No
No
Atha\CYP709B2
3 of 9
No
No
Atha\CYP709B3
3 of 9
No
No
Atha\CYP714A1
3 of 9
No
No
Atha\CYP714A2
3 of 9
No
No
Atha\CYP721A1
3 of 9
No
No
Atha\CYP72C1
2 of 9
No
No
Atha\CYP86A1
2 of 9
No
No
Atha\CYP86A2
2 of 9
No
Yes
Atha\CYP86A7
2 of 9
No
No
Atha\CYP86A8
2 of 9
No
No
Atha\CYP86C2
2 of 9
No
Yes
Atha\CYP94C1
2 of 9
No
No
Atha\CYP96A1
2 of 9
No
No
Atha\CYP96A2
2 of 9
No
No
Atha\CYP96A3
2 of 9
No
No
Atha\CYP96A4
2 of 9
No
No
Atha\CYP96A5
2 of 9
No
No
Atha\CYP96A8
2 of 9
No
No
Atha\CYP96A10
2 of 9
No
No
Atha\CYP96A11
2 of 9
No
No
Atha\CYP96A12
2 of 9
No
No
Atha\CYP96A13
2 of 9
No
No
Atha\CYP96A15
2 of 9
No
No
Atha\CYP97B3
2 of 9
No
No
Atha\LUT1
2 of 9
No
No
Atha\AT3G44970
1 of 9
No
Yes
Atha\AT5G51900
1 of 9
No
Yes
Atha\CPD
1 of 9
No
Yes
Atha\CYP71A18
1 of 9
No
No
Atha\CYP76C3
1 of 9
No
No
Atha\CYP87A2
1 of 9
No
Yes
Atha\CYP96A9
1 of 9
No
No
Atha\CYP96A14P
1 of 9
No
Yes
Atha\CYP702A1
1 of 9
No
Yes
Atha\CYP702A3
1 of 9
No
Yes
Atha\CYP702A5
1 of 9
No
Yes
Atha\CYP702A6
1 of 9
No
Yes
Atha\CYP702A8
1 of 9
No
Yes
Atha\CYP705A1
1 of 9
No
No
Atha\CYP705A20
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ERG5
2 of 15
Yes
No
Scer\DIT2
1 of 15
No
No
Scer\ERG11
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\erg11
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091906CL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005250
Drosophila simulans
Dsim\Cyp4d1
Drosophila sechellia
Dsec\GM18912
Drosophila erecta
Dere\GG12646
Drosophila yakuba
Dyak\GE16973
Drosophila ananassae
Dana\GF21204
Drosophila pseudoobscura pseudoobscura
Dpse\GA28945
Drosophila persimilis
Dper\GL20343
Drosophila willistoni
Dwil\GK25786
Drosophila mojavensis
Dmoj\GI16117
Drosophila grimshawi
Dgri\GH24654
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505AZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022156
Musca domestica
House fly
Mdoa\17013408
Musca domestica
House fly
Mdoa\17008413
Musca domestica
House fly
Mdoa\17025329
Musca domestica
House fly
Mdoa\17004965
Musca domestica
House fly
Mdoa\17015373
Musca domestica
House fly
Mdoa\17022088
Musca domestica
House fly
Mdoa\17022159
Musca domestica
House fly
Mdoa\17022087
Musca domestica
House fly
Mdoa\17015375
Musca domestica
House fly
Mdoa\17023553
Musca domestica
House fly
Mdoa\17006469
Musca domestica
House fly
Mdoa\17022154
Musca domestica
House fly
Mdoa\17023554
Musca domestica
House fly
Mdoa\17008414
Musca domestica
House fly
Mdoa\17022157
Musca domestica
House fly
Mdoa\17015376
Musca domestica
House fly
Mdoa\17024861
Musca domestica
House fly
Mdoa\17015374
Musca domestica
House fly
Mdoa\17022161
Musca domestica
House fly
Mdoa\17022158
Musca domestica
House fly
Mdoa\17007205
Musca domestica
House fly
Mdoa\17022155
Glossina morsitans
Tsetse fly
Gmor\GMOY006215
Glossina morsitans
Tsetse fly
Gmor\GMOY010311
Glossina morsitans
Tsetse fly
Gmor\GMOY009909
Glossina morsitans
Tsetse fly
Gmor\GMOY007652
Glossina morsitans
Tsetse fly
Gmor\GMOY006475
Glossina morsitans
Tsetse fly
Gmor\GMOY006211
Glossina morsitans
Tsetse fly
Gmor\GMOY006212
Glossina morsitans
Tsetse fly
Gmor\GMOY006214
Glossina morsitans
Tsetse fly
Gmor\GMOY008768
Glossina morsitans
Tsetse fly
Gmor\GMOY001939
Glossina morsitans
Tsetse fly
Gmor\GMOY006213
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03709
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03386
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03390
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03388
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03949
Mayetiola destructor
Hessian fly
Mdes\Mdes010393
Mayetiola destructor
Hessian fly
Mdes\Mdes007962
Mayetiola destructor
Hessian fly
Mdes\Mdes014885
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4J15
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4D38
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4D24
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4J14
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4J13
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4D37
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014830
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015663
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4J17
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4D39
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4D23
Anopheles darlingi
American malaria mosquito
Adar\ADAC005619
Anopheles darlingi
American malaria mosquito
Adar\ADAC000697
Anopheles darlingi
American malaria mosquito
Adar\ADAC005623
Anopheles darlingi
American malaria mosquito
Adar\ADAC000698
Anopheles darlingi
American malaria mosquito
Adar\ADAC000699
Anopheles gambiae
Malaria mosquito
Agam\CYP4J10
Anopheles gambiae
Malaria mosquito
Agam\CYP4D22
Anopheles gambiae
Malaria mosquito
Agam\CYP4D15
Anopheles gambiae
Malaria mosquito
Agam\CYP4D17
Anopheles gambiae
Malaria mosquito
Agam\CYP4D16
Anopheles gambiae
Malaria mosquito
Agam\CYP4J5
Anopheles gambiae
Malaria mosquito
Agam\CYP4J9
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001759
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4J18
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ009477
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4D41
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001754
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4D43
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016284
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4D40
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001755
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4D44
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4D42
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ020229
Culex quinquefasciatus
Southern house mosquito
Cqui\CYP4J20
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03JG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\LOC100127115
Bombyx mori
Silkmoth
Bmor\BGIBMGA001005
Bombyx mori
Silkmoth
Bmor\BGIBMGA001162
Bombyx mori
Silkmoth
Bmor\BGIBMGA003683
Bombyx mori
Silkmoth
Bmor\BGIBMGA001003
Danaus plexippus
Monarch butterfly
Dple\DPOGS212789-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215623-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205654-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201061-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205157-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215622-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211931-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008770
Heliconius melpomene
Postman butterfly
Hmel\HMEL003583
Heliconius melpomene
Postman butterfly
Hmel\HMEL005933
Heliconius melpomene
Postman butterfly
Hmel\HMEL003581
Heliconius melpomene
Postman butterfly
Hmel\HMEL005932
Heliconius melpomene
Postman butterfly
Hmel\HMEL009876
Heliconius melpomene
Postman butterfly
Hmel\HMEL003584
Heliconius melpomene
Postman butterfly
Hmel\HMEL006588
Heliconius melpomene
Postman butterfly
Hmel\HMEL002471
Heliconius melpomene
Postman butterfly
Hmel\HMEL006024
Heliconius melpomene
Postman butterfly
Hmel\HMEL016705
Heliconius melpomene
Postman butterfly
Hmel\HMEL008768
Heliconius melpomene
Postman butterfly
Hmel\HMEL010693
Heliconius melpomene
Postman butterfly
Hmel\HMEL003582
Apis florea
Little honeybee
Aflo\2262004468
Apis florea
Little honeybee
Aflo\2147749907
Apis florea
Little honeybee
Aflo\3200303956
Apis mellifera
Western honey bee
Amel\GB47270
Apis mellifera
Western honey bee
Amel\CYP4AV1
Apis mellifera
Western honey bee
Amel\GB51356
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17222
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20078
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15257
Bombus terrestris
Buff-tailed bumblebee
Bter\15208673
Bombus terrestris
Buff-tailed bumblebee
Bter\15205936
Bombus terrestris
Buff-tailed bumblebee
Bter\15212474
Linepithema humile
Argentine ant
Lhum\LH24978
Linepithema humile
Argentine ant
Lhum\LH16316
Linepithema humile
Argentine ant
Lhum\LH10682
Linepithema humile
Argentine ant
Lhum\LH22782
Linepithema humile
Argentine ant
Lhum\LH25003
Linepithema humile
Argentine ant
Lhum\LH21674
Linepithema humile
Argentine ant
Lhum\LH14939
Linepithema humile
Argentine ant
Lhum\LH22783
Linepithema humile
Argentine ant
Lhum\LH22785
Linepithema humile
Argentine ant
Lhum\LH10850
Linepithema humile
Argentine ant
Lhum\LH23345
Linepithema humile
Argentine ant
Lhum\LH22786
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d3d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000788
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0001f1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010254
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012361
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008110
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013770
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012360
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010775
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000732
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015477
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012359
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007621
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008212
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG037124
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013401
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012056
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020600
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003406
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009254
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008109
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008685
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012057
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019580
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005578
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003405
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004151
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00676
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06739
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07362
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04191
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01611
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00113
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05824
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07200
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00566
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00528
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03628
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03851
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03213
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01031
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05823
Tribolium castaneum
Red flour beetle
Tcas\TC015343
Tribolium castaneum
Red flour beetle
Tcas\TC033333
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07061
Tribolium castaneum
Red flour beetle
Tcas\TC010423
Tribolium castaneum
Red flour beetle
Tcas\CYP4BR3
Tribolium castaneum
Red flour beetle
Tcas\TC012503
Tribolium castaneum
Red flour beetle
Tcas\TC009412
Tribolium castaneum
Red flour beetle
Tcas\TC012498
Tribolium castaneum
Red flour beetle
Tcas\TC012501
Tribolium castaneum
Red flour beetle
Tcas\TC013681
Tribolium castaneum
Red flour beetle
Tcas\TC012662
Tribolium castaneum
Red flour beetle
Tcas\TC015292
Tribolium castaneum
Red flour beetle
Tcas\TC002722
Tribolium castaneum
Red flour beetle
Tcas\TC014125
Tribolium castaneum
Red flour beetle
Tcas\TC033050
Tribolium castaneum
Red flour beetle
Tcas\TC012500
Tribolium castaneum
Red flour beetle
Tcas\TC013679
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08058
Tribolium castaneum
Red flour beetle
Tcas\TC034363
Tribolium castaneum
Red flour beetle
Tcas\TC033334
Tribolium castaneum
Red flour beetle
Tcas\TC015992
Tribolium castaneum
Red flour beetle
Tcas\TC015291
Tribolium castaneum
Red flour beetle
Tcas\TC033335
Tribolium castaneum
Red flour beetle
Tcas\TC012504
Tribolium castaneum
Red flour beetle
Tcas\TC012499
Tribolium castaneum
Red flour beetle
Tcas\CYP4Q7
Tribolium castaneum
Red flour beetle
Tcas\TC013680
Tribolium castaneum
Red flour beetle
Tcas\TC002721
Tribolium castaneum
Red flour beetle
Tcas\TC013773
Tribolium castaneum
Red flour beetle
Tcas\TC012495
Tribolium castaneum
Red flour beetle
Tcas\TC014641
Tribolium castaneum
Red flour beetle
Tcas\TC003368
Pediculus humanus
Human body louse
Phum\PHUM452970
Pediculus humanus
Human body louse
Phum\PHUM371380
Pediculus humanus
Human body louse
Phum\PHUM371390
Pediculus humanus
Human body louse
Phum\PHUM458480
Pediculus humanus
Human body louse
Phum\PHUM063470
Pediculus humanus
Human body louse
Phum\PHUM019500
Pediculus humanus
Human body louse
Phum\PHUM452980
Pediculus humanus
Human body louse
Phum\PHUM371370
Rhodnius prolixus
Kissing bug
Rpro\RPRC015287
Rhodnius prolixus
Kissing bug
Rpro\RPRC004769
Rhodnius prolixus
Kissing bug
Rpro\RPRC000027
Rhodnius prolixus
Kissing bug
Rpro\RPRC004731
Rhodnius prolixus
Kissing bug
Rpro\RPRC000196
Rhodnius prolixus
Kissing bug
Rpro\RPRC015286
Rhodnius prolixus
Kissing bug
Rpro\RPRC003227
Rhodnius prolixus
Kissing bug
Rpro\RPRC004766
Rhodnius prolixus
Kissing bug
Rpro\RPRC013847
Rhodnius prolixus
Kissing bug
Rpro\RPRC004758
Rhodnius prolixus
Kissing bug
Rpro\RPRC004733
Cimex lectularius
Bed bug
Clec\CLEC005851
Cimex lectularius
Bed bug
Clec\CLEC005721
Cimex lectularius
Bed bug
Clec\CLEC004796
Cimex lectularius
Bed bug
Clec\CLEC007341
Cimex lectularius
Bed bug
Clec\CLEC012067
Cimex lectularius
Bed bug
Clec\CLEC025147
Cimex lectularius
Bed bug
Clec\CLEC013923
Cimex lectularius
Bed bug
Clec\CLEC007343
Cimex lectularius
Bed bug
Clec\CLEC005850
Cimex lectularius
Bed bug
Clec\CLEC005720
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007609
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI56605
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000176
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI44407
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001913
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005733
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005113
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002628
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085487
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003803
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069651
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05398
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09478
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13889
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09480
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05391
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08930
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05390
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16223
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09481
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14590
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03222
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03G3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008771
Strigamia maritima
European centipede
Smar\SMAR008770
Strigamia maritima
European centipede
Smar\SMAR005769
Strigamia maritima
European centipede
Smar\SMAR008807
Strigamia maritima
European centipede
Smar\SMAR008806
Strigamia maritima
European centipede
Smar\SMAR012322
Strigamia maritima
European centipede
Smar\SMAR008774
Ixodes scapularis
Black-legged tick
Isca\ISCW022703
Ixodes scapularis
Black-legged tick
Isca\ISCW022704
Ixodes scapularis
Black-legged tick
Isca\ISCW022706
Ixodes scapularis
Black-legged tick
Isca\ISCW022705
Ixodes scapularis
Black-legged tick
Isca\ISCW013762
Ixodes scapularis
Black-legged tick
Isca\ISCW022699
Ixodes scapularis
Black-legged tick
Isca\ISCW003279
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80254.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74841.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58190.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65253.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62443.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75827.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65323.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61188.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63207.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00650
Tetranychus urticae
Two-spotted spider mite
Turt\tetur36g00920
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g03800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311383
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305575
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305713
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311767
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311594
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_340592
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_221284
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42067
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309254
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_329890
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311385
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305686
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_235307
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_192258
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42144
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312044
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303449
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_96133
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311475
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311593
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311387
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_50258
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311388
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42950
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311394
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306533
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_320218
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312048
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311596
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311474
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_206765
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42254
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311386
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311473
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06KN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL6
Ciona intestinalis
Vase tunicate
Cint\LOC100179192
Ciona intestinalis
Vase tunicate
Cint\LOC100180750
Ciona intestinalis
Vase tunicate
Cint\LOC100187185
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012965
Ciona intestinalis
Vase tunicate
Cint\LOC100183395
Ciona intestinalis
Vase tunicate
Cint\LOC100186171
Ciona intestinalis
Vase tunicate
Cint\LOC100181903
Ciona intestinalis
Vase tunicate
Cint\LOC100175798
Ciona intestinalis
Vase tunicate
Cint\LOC100181326
Gallus gallus
Domestic chicken
Ggal\CYP4V2
Gallus gallus
Domestic chicken
Ggal\LOC771974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026611
Gallus gallus
Domestic chicken
Ggal\CYP4B1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (49)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cyp4ac1
6 of 10
Cyp4ac2
6 of 10
Cyp4ac3
6 of 10
Cyp4ad1
6 of 10
Cyp4c3
6 of 10
Cyp4d2
6 of 10
Cyp4d14
6 of 10
Cyp4d20
6 of 10
Cyp4d21
6 of 10
Cyp4e1
6 of 10
Cyp4e2
6 of 10
Cyp4e3
6 of 10
Cyp4p1
6 of 10
Cyp4p2
6 of 10
Cyp4p3
6 of 10
Cyp4s3
6 of 10
Cyp4ae1
5 of 10
Cyp4d8
5 of 10
Cyp312a1
5 of 10
Cyp4aa1
4 of 10
Cyp4g1
4 of 10
Cyp4g15
4 of 10
Cyp311a1
4 of 10
Cyp316a1
4 of 10
Cyp313b1
3 of 10
Cyp6a23
2 of 10
Cyp313a1
2 of 10
Cyp313a2
2 of 10
Cyp313a3
2 of 10
Cyp313a4
2 of 10
Cyp313a5
2 of 10
Cyp318a1
2 of 10
Cyp6a2
1 of 10
Cyp6a8
1 of 10
Cyp6a9
1 of 10
Cyp6a17
1 of 10
Cyp6a18
1 of 10
Cyp6a19
1 of 10
Cyp6a21
1 of 10
Cyp6a22
1 of 10
Cyp6t1
1 of 10
Cyp6t3
1 of 10
Cyp9b1
1 of 10
Cyp9b2
1 of 10
Cyp9c1
1 of 10
Cyp9f2
1 of 10
Cyp9h1
1 of 10
Cyp309a2
1 of 10
sad
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CYP4V2; cytochrome P450 family 4 subfamily V member 2
    6 of 15
    608614
    CYP4X1; cytochrome P450 family 4 subfamily X member 1
    5 of 15
    614999
        CYP4Z1; cytochrome P450 family 4 subfamily Z member 1
        5 of 15
        618953
            CYP4A22; cytochrome P450 family 4 subfamily A member 22
            4 of 15
            615341
                CYP4B1; cytochrome P450 family 4 subfamily B member 1
                4 of 15
                124075
                    CYP4F2; cytochrome P450 family 4 subfamily F member 2
                    4 of 15
                    604426
                        CYP4F3; cytochrome P450 family 4 subfamily F member 3
                        4 of 15
                        601270
                            CYP4F8; cytochrome P450 family 4 subfamily F member 8
                            4 of 15
                            611545
                                CYP4F11; cytochrome P450 family 4 subfamily F member 11
                                4 of 15
                                611517
                                    CYP4F12; cytochrome P450 family 4 subfamily F member 12
                                    4 of 15
                                    611485
                                        CYP4F22; cytochrome P450 family 4 subfamily F member 22
                                        4 of 15
                                        611495
                                        CYP19A1; cytochrome P450 family 19 subfamily A member 1
                                        4 of 15
                                        107910
                                        CYP4A11; cytochrome P450 family 4 subfamily A member 11
                                        3 of 15
                                        601310
                                            Functional Complementation Data
                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                            Interactions
                                            Summary of Physical Interactions
                                            esyN Network Diagram
                                            Interactions Browser
                                            Summary of Genetic Interactions
                                            esyN Network Diagram
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            Starting gene(s)
                                            Interaction type
                                            Interacting gene(s)
                                            Reference
                                            External Data
                                            Linkouts
                                            DroID - A comprehensive database of gene and protein interactions.
                                            Pathways
                                            Signaling Pathways (FlyBase)
                                            Metabolic Pathways
                                            External Data
                                            Linkouts
                                            Genomic Location and Detailed Mapping Data
                                            Chromosome (arm)
                                            X
                                            Recombination map
                                            1-0.6
                                            Cytogenetic map
                                            2D5-2D6
                                            Sequence location
                                            X:2,159,145..2,162,180 [-]
                                            FlyBase Computed Cytological Location
                                            Cytogenetic map
                                            Evidence for location
                                            2D5-2D6
                                            Limits computationally determined from genome sequence between P{EP}ActnEP1193&P{EP}CG4322EP1631 and P{EP}EP1460&P{EP}CG2924EP1596
                                            Experimentally Determined Cytological Location
                                            Cytogenetic map
                                            Notes
                                            References
                                            2D6-2E1
                                            (Dunkov, 2000.6.29)
                                            2D-2D
                                            (determined by in situ hybridisation)
                                            (Dunkov et al., 1996)
                                            2D4-2D6
                                            (determined by in situ hybridisation)
                                            (Gandhi et al., 1992)
                                            Experimentally Determined Recombination Data
                                            Location

                                            1-0.6

                                            (FlyBase, 2016)

                                            1-0.2

                                            (Comeron et al., 2012)
                                            Left of (cM)
                                            Right of (cM)
                                            Notes
                                            Stocks and Reagents
                                            Stocks (5)
                                            Genomic Clones (8)
                                             

                                            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                            cDNA Clones (60)
                                             

                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                            cDNA clones, fully sequenced
                                            BDGP DGC clones
                                            Other clones
                                              Drosophila Genomics Resource Center cDNA clones

                                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                              cDNA Clones, End Sequenced (ESTs)
                                              BDGP DGC clones
                                              Other clones
                                              RNAi and Array Information
                                              Linkouts
                                              DRSC - Results frm RNAi screens
                                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                              Antibody Information
                                              Laboratory Generated Antibodies
                                               
                                              Commercially Available Antibodies
                                               
                                              Other Information
                                              Relationship to Other Genes
                                              Source for database identify of
                                              Source for database merge of
                                              Additional comments
                                              Other Comments

                                              Identified molecularly using degenerate PCR primers designed from conserved regions of known insect P450 genes.

                                              (Dunkov et al., 1996)

                                              The adenylate cyclase inactivator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin inhibit, in a dose-dependent fashion, the ecdysone 20-monooxygenase activity associated with wandering stage larvae.

                                              (Keogh et al., 1992)

                                              Maps between Pgd and pn; does not correspond to any known lethal complementation group.

                                              Origin and Etymology
                                              Discoverer
                                              Etymology
                                              Identification
                                              External Crossreferences and Linkouts ( 65 )
                                              Sequence Crossreferences
                                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                              Other crossreferences
                                              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                              DRscDB
                                              EMBL-EBI Single Cell Expression Atlas
                                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                              Flygut - An atlas of the Drosophila adult midgut
                                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                              InterPro - A database of protein families, domains and functional sites
                                              KEGG Genes - Molecular building blocks of life in the genomic space.
                                              MARRVEL_MODEL
                                              modMine - A data warehouse for the modENCODE project
                                              Linkouts
                                              DroID - A comprehensive database of gene and protein interactions.
                                              DRSC - Results frm RNAi screens
                                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                              FlyMine - An integrated database for Drosophila genomics
                                              Synonyms and Secondary IDs (16)
                                              Datasets (0)
                                              Study focus (0)
                                              Experimental Role
                                              Project
                                              Project Type
                                              Title
                                              References (92)