FlyBase Gene Report: Dmel\Cyp4d1

General Information

Symbol

Dmel\Cyp4d1

Species

D. melanogaster

Name

Cytochrome P450 4d1

Annotation Symbol

CG3656

Feature Type

protein_coding_gene

FlyBase ID

FBgn0005670

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProt, P33269)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

P450, EG:87B1.1

Key Links

Genomic Location

Cytogenetic map

2D5-2D6

Sequence location

X:2,159,145..2,162,180 [-]

Recombination map

1-0.6

RefSeq locus

NC_004354 REGION:2159145..2162180

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables heme binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables iron ion binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables monooxygenase activity

inferred from biological aspect of ancestor with PANTHER:PTN002386818

(assigned by GO_Central )

(Gaudet et al., 2011)

enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYTOCHROME P450 - CYP4 CLAN

Protein Family (UniProt)

Belongs to the cytochrome P450 family. (P33269)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOCHROME P450 - CYP4 CLAN -: Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP4 clan includes D. melanogaster CYP4, 311-313, 316 and 318 family genes. Few CYP4 enzymes have been characterized, though some CYP4 genes are inducible by xenobiotics. (Adapted from FBrf0248421.)

Protein Function (UniProtKB)

Involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

(UniProt, P33269)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp4d1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P33269)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.51

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp4d1-RA

FBtr0070428

NM_057559

1685

512

Cyp4d1-RB

FBtr0070427

NM_166932

1644

503

Additional Transcript Data and Comments

Reported size (kB)

1.7 (northern blot)

(Gandhi et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Cyp4d1-PA

FBpp0070412

58.7

512

7.20

NP_476907

AAF45737

Cyp4d1-PB

FBpp0070411

57.4

503

7.09

NP_726797

AAF45736

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

511 (aa)

(Gandhi et al., 1992)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp4d1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

(Gandhi et al., 1992)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic/larval midgut

Comment: em3

(Chung et al., 2009)

third instar larval stage

embryonic/larval midgut

Comment: m1-2, m6

(Chung et al., 2009)

embryonic/larval fat body

(Chung et al., 2009)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Gandhi et al., 1992)

Additional Descriptive Data

Cyp4d1 transcripts are detected throughout development on northern blots but the highest accumulation of transcripts occurs in late larval stages.

(Gandhi et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp4d1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp4d1

View exonic expression by tissue for Dmel\Cyp4d1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005670

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31188/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005670

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005670

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005670

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3656

Flygut - An atlas of the Drosophila adult midgut

FBgn0005670

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp4d1

Transgenic constructs containing regulatory region of Cyp4d1

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(1)Exel6289

(Ryder, 2004.4.26)

Gene not disrupted in

Df(1)ph^del

(Feng et al., 2011)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyp4d1^GD3198

viable, with Scer\GAL4^Mef2.PR

Cyp4d1^GD3198

viable, with Scer\GAL4^pnr-MD237

Cyp4d1^GD3198

viable, with Scer\GAL4^tin.CΔ4

Cyp4d1^GD3198

Phenotype manifest in

Allele

embryonic/larval fat body | wandering third instar larval stage, with Scer\GAL4^ppl.PP

Cyp4d1^NIG.3656R

lipid droplet | wandering third instar larval stage, with Scer\GAL4^ppl.PP

Cyp4d1^NIG.3656R

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (23)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CYP4V2

6 of 15

Yes

Hsap\CYP4X1

5 of 15

Yes

Hsap\CYP4Z1

5 of 15

Yes

Hsap\CYP4A22

4 of 15

Yes

Hsap\CYP4B1

4 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

Yes

Hsap\CYP4F12

4 of 15

Hsap\CYP4F22

4 of 15

Yes

4 of 15

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (38)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Cyp4v3

6 of 15

Yes

Mmus\Cyp4a12a

4 of 15

Yes

Mmus\Cyp4a12b

4 of 15

Yes

Mmus\Cyp4a14

4 of 15

Yes

Mmus\Cyp4a31

4 of 15

Yes

Mmus\Cyp4a32

4 of 15

Mmus\Cyp4b1

4 of 15

Yes

Mmus\Cyp4f13

4 of 15

Yes

4 of 15

4 of 15

4 of 15

4 of 15

4 of 15

Yes

Mmus\Cyp19a1

4 of 15

Mmus\Cyp4a10

3 of 15

Yes

Mmus\Cyp4a29

3 of 15

Yes

Mmus\Cyp4a30b

3 of 15

Yes

3 of 15

3 of 15

3 of 15

3 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (30)

Rnor\Cyp4v3

5 of 13

Yes

Rnor\Cyp4a8

4 of 13

Yes

Rnor\Cyp4b1

4 of 13

Yes

Rnor\Cyp4f1

4 of 13

Yes

Rnor\Cyp4f18

4 of 13

Yes

Rnor\Cyp4f39

4 of 13

Yes

Rnor\Cyp19a1

4 of 13

Yes

Rnor\Cyp4a2

3 of 13

Rnor\Cyp4a3

3 of 13

Yes

Rnor\Cyp4f4

3 of 13

Yes

Rnor\Cyp4f6

3 of 13

Yes

Rnor\Cyp4f17

3 of 13

Yes

Rnor\Cyp4f37

3 of 13

Yes

Rnor\Cyp4f40

3 of 13

Yes

Rnor\Cyp4a1

2 of 13

Rnor\Cyp4f5

2 of 13

Rnor\Cyp4x1

2 of 13

Yes

Rnor\Cyp3a18

1 of 13

Rnor\Cyp3a62

1 of 13

Rnor\Cyp3a71-ps

1 of 13

Yes

Rnor\Cyp20a1

1 of 13

Yes

Rnor\Cyp26a1

1 of 13

Yes

Rnor\Cyp26b1

1 of 13

Yes

Rnor\Cyp26c1

1 of 13

Yes

Rnor\Cyp46a1

1 of 13

Rnor\LOC680316

1 of 13

Yes

Rnor\LOC100910877

1 of 13

Rnor\LOC100912391

1 of 13

Yes

Rnor\LOC103692784

1 of 13

Yes

Rnor\Pdgfrb

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\cyp4v2

4 of 12

Yes

Xtro\cyp19a1

4 of 12

Yes

Xtro\cyp4b1.2

3 of 12

Yes

Xtro\cyp4b1

3 of 12

Yes

Xtro\cyp4f2

3 of 12

Yes

Xtro\cyp4f22

3 of 12

Yes

Xtro\LOC100487918

3 of 12

Yes

Xtro\LOC100488227

3 of 12

Yes

Xtro\cyp20a1

1 of 12

Yes

Xtro\cyp26a1

1 of 12

Yes

Xtro\cyp26b1

1 of 12

Yes

Xtro\cyp26c1

1 of 12

Yes

Xtro\LOC100485929

1 of 12

Xtro\LOC100487846

1 of 12

Xtro\LOC100488078

1 of 12

Yes

Xtro\LOC100488386

1 of 12

Yes

Xtro\mgc108213

1 of 12

Danio rerio (Zebrafish) (22)

Drer\cyp4v7

6 of 15

Yes

Drer\cyp4v8

6 of 15

Yes

Drer\cyp4f3

4 of 15

Yes

Drer\cyp4t8

4 of 15

Yes

Drer\cyp19a1a

4 of 15

Yes

Drer\cyp19a1b

2 of 15

Yes

Drer\cyp46a1.3

2 of 15

Yes

Drer\zgc:123299

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\cyp26a1

1 of 15

Drer\cyp26b1

1 of 15

Yes

Drer\cyp26c1

1 of 15

Yes

Drer\cyp46a1.1

1 of 15

Drer\cyp46a1.2

1 of 15

Drer\cyp46a1.4

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (29)

Cele\cyp-31A2

7 of 15

Yes

Cele\cyp-31A3

7 of 15

Yes

Cele\cyp-29A3

6 of 15

Yes

Cele\cyp-29A4

6 of 15

Yes

Cele\cyp-31A5

6 of 15

Yes

Cele\cyp-42A1

5 of 15

Cele\cyp-29A2

4 of 15

Yes

4 of 15

4 of 15

4 of 15

3 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (68)

Atha\AT5G08250

4 of 9

Yes

Atha\BAS1

4 of 9

Yes

Atha\CYP72A8

4 of 9

Yes

Atha\CYP72A9

4 of 9

Yes

Atha\CYP72A10

4 of 9

Yes

Atha\CYP72A11

4 of 9

Yes

Atha\CYP72A13

4 of 9

Yes

Atha\CYP72A14

4 of 9

Yes

Atha\CYP72A15

4 of 9

Yes

Atha\CYP86B1

4 of 9

Yes

Atha\CYP94B2

4 of 9

Yes

Atha\CYP704B1

4 of 9

Yes

Atha\CYP715A1

4 of 9

Yes

Atha\CYP735A1

4 of 9

Yes

Atha\CYP735A2

4 of 9

Yes

Atha\CYP72A7

3 of 9

Atha\CYP86A4

3 of 9

Yes

Atha\CYP86C1

3 of 9

Yes

Atha\CYP86C3

3 of 9

Yes

Atha\CYP86C4

3 of 9

Yes

Atha\CYP94B1

3 of 9

Yes

Atha\CYP94B3

3 of 9

Yes

Atha\CYP94D1

3 of 9

Yes

Atha\CYP94D2

3 of 9

Yes

3 of 9

3 of 9

3 of 9

3 of 9

3 of 9

3 of 9

3 of 9

3 of 9

3 of 9

2 of 9

2 of 9

2 of 9

Yes

Atha\CYP86A7

2 of 9

Atha\CYP86A8

2 of 9

Atha\CYP86C2

2 of 9

Yes

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

1 of 9

Yes

Atha\AT5G51900

1 of 9

Yes

Atha\CPD

1 of 9

Yes

Atha\CYP71A18

1 of 9

Atha\CYP76C3

1 of 9

Atha\CYP87A2

1 of 9

Yes

Atha\CYP96A9

1 of 9

Atha\CYP96A14P

1 of 9

Yes

Atha\CYP702A1

1 of 9

Yes

Atha\CYP702A3

1 of 9

Yes

Atha\CYP702A5

1 of 9

Yes

Atha\CYP702A6

1 of 9

Yes

Atha\CYP702A8

1 of 9

Yes

Atha\CYP705A1

1 of 9

Atha\CYP705A20

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ERG5

2 of 15

Yes

Scer\DIT2

1 of 15

Scer\ERG11

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\erg11

1 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (49)

Gene Symbol

Score

Source

Alignment

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

6 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

4 of 10

4 of 10

4 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

sad

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

CYP4V2; cytochrome P450 family 4 subfamily V member 2

model of Bietti crystalline corneoretinal dystrophy

IEA

(FlyBase, 2019-)

CYP4F22; cytochrome P450 family 4 subfamily F member 22

model of autosomal recessive congenital ichthyosis 5

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYP4V2; cytochrome P450 family 4 subfamily V member 2

6 of 15

608614

BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY; BCD

Bietti crystalline corneoretinal dystrophy

CYP4X1; cytochrome P450 family 4 subfamily X member 1

5 of 15

614999

CYP4Z1; cytochrome P450 family 4 subfamily Z member 1

5 of 15

618953

CYP4A22; cytochrome P450 family 4 subfamily A member 22

4 of 15

615341

CYP4B1; cytochrome P450 family 4 subfamily B member 1

4 of 15

124075

CYP4F2; cytochrome P450 family 4 subfamily F member 2

4 of 15

604426

CYP4F3; cytochrome P450 family 4 subfamily F member 3

4 of 15

601270

CYP4F8; cytochrome P450 family 4 subfamily F member 8

4 of 15

611545

CYP4F11; cytochrome P450 family 4 subfamily F member 11

4 of 15

611517

CYP4F12; cytochrome P450 family 4 subfamily F member 12

4 of 15

611485

CYP4F22; cytochrome P450 family 4 subfamily F member 22

4 of 15

611495

ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 5; ARCI5

autosomal recessive congenital ichthyosis 5

CYP19A1; cytochrome P450 family 19 subfamily A member 1

4 of 15

107910

aromatase excess syndrome

CYP4A11; cytochrome P450 family 4 subfamily A member 11

3 of 15

601310

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0005670

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0005670

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.6

Cytogenetic map

2D5-2D6

Sequence location

X:2,159,145..2,162,180 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2D5-2D6

Limits computationally determined from genome sequence between P{EP}Actn^EP1193&P{EP}CG4322^EP1631 and P{EP}EP1460&P{EP}CG2924^EP1596

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

2D6-2E1

(Dunkov, 2000.6.29)

2D-2D

(determined by in situ hybridisation)

(Dunkov et al., 1996)

2D4-2D6

(determined by in situ hybridisation)

(Gandhi et al., 1992)

Experimentally Determined Recombination Data

Location

1-0.6

(FlyBase, 2016)

1-0.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

26076

Mi{ET1}Cyp4d1^MB07195 w¹¹¹⁸

52979

y¹ v¹; P{TRiP.HMJ21666}attP40

91850

y¹ sc^* v¹ sev²¹; P{SAM.dCas9.GS05630}attP40/CyO

VDRC

v109341

P{KK112755}VIE-260B

v12190

w¹¹¹⁸; P{GD3198}v12190/CyO

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (60)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LP06368

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0005670

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0005670

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31188

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Identified molecularly using degenerate PCR primers designed from conserved regions of known insect P450 genes.

(Dunkov et al., 1996)

The adenylate cyclase inactivator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin inhibit, in a dose-dependent fashion, the ecdysone 20-monooxygenase activity associated with wandering stage larvae.

(Keogh et al., 1992)

Maps between Pgd and pn; does not correspond to any known lethal complementation group.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 69 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31188

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P33269

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P33269

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8MS75

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P33269

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005670

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0005670

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31188/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005670

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005670

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005670

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3656

Flygut - An atlas of the Drosophila adult midgut

FBgn0005670

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0005670

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31188

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3656

MARRVEL_MODEL - MARRVEL (model organism gene)

31188

modMine - A data warehouse for the modENCODE project

FBgn0005670

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0005670

DRSC - Results frm RNAi screens

FBgn0005670

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0005670

FlyMine - An integrated database for Drosophila genomics

FBgn0005670

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

4d1

(Nelson, 2001.2.5)

CG3656

(Fan et al., 2017, Aradska et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Li et al., 2009, Beller et al., 2006, Kang et al., 2002, Benos, 2000.12.13)

CYP4D1

(Li et al., 2009, Verni et al., 2000, Danielson et al., 1998, Scott et al., 1998, Bauer and Aquadro, 1997, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Phillips, 1997.8.4, Gandhi et al., 1992)

CYP6D1

(Lin et al., 2011)

Cyp4D1

(Li et al., 2008)

Cyp4d1

(Scanlan et al., 2020, Joos et al., 2018, Fan et al., 2017, Transgenic RNAi Project members, 2017-, Carnes et al., 2015, Japanese National Institute of Genetics, 2012.5.21, Zhou et al., 2012, Feng et al., 2011, Niwa et al., 2011, Kong et al., 2010, Li et al., 2010, Beller et al., 2006, Davies et al., 2006)

Cyt-P450-4D1

EG:87B1.1

(Benos et al., 2001, Benos, 2000.12.13)

P-450

(Danielson et al., 1995)

P450

(Arking, 1998, Zakharenko and Zakharov, 1998, Alatortsev, 1997, Frolich and Wurgler, 1991)

cyp4d1

(Comet et al., 2006)

Name Synonyms

Cytochrome P450 4D1

Cytochrome P450 4d1