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General Information
Symbol
Dmel\spi
Species
D. melanogaster
Name
spitz
Annotation Symbol
CG10334
Feature Type
FlyBase ID
FBgn0005672
Gene Model Status
Stock Availability
Gene Snapshot
spitz (spi) encodes the cardinal Egfr ligand that is produced as a transmembrane precursor and processed by the products of S and rho. Its roles include growth regulation, cell survival and developmental patterning. [Date last reviewed: 2019-03-14]
Also Known As
sSpi, l(2)s3547, l(2)01068, s-spi
Key Links
Genomic Location
Cytogenetic map
Sequence location
2L:19,567,900..19,577,315 [-]
Recombination map
2-54
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Pathway (FlyBase)
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Gene Group (FlyBase)
EGFR AGONISTS -
Epidermal Growth Factor Receptor (EGFR) agonists are secreted ligands that activate the Egfr receptor tyrosine kinase.
Protein Function (UniProtKB)
Ligand for the EGF receptor (Gurken). Involved in a number of unrelated developmental choices, for example, dorsal-ventral axis formation, glial migration, sensory organ determination, and muscle development. It is required for photoreceptor determination.
(UniProt, Q01083)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
spi: spitz
Embryonic lethal. Normal allele required for normal development of blastoderm cells just lateral to the ventral mesodermal precursors. Denticle bands narrower than normal; first row often missing; reversal of polarity between anterior and posterior rows not seen; irregular fusion in midline of adjacent dentical bands. Keilin's organs missing or strongly reduced. Labrum, antennal-maxillary complex and labial sense organ reduced in size; right and left halves of head skeleton fused to produce pointed appearance. Tail region normal. Right and left halves of ventral ganglia of the central nervous system closer together than normal resulting in shorter commissures. The cells in the CNS that stain with anti-eve+ antibodies are closer together in spi than in wild type. spi+ required in the female germ line; spi pole cells transplanted into normal embryos produce no progeny.
Summary (Interactive Fly)
ligand for Epidermal growth factor receptor - Egf/Tgf alpha homolog - required for the differentiation of all ommatidial cell types, with the exception of R8 - Spi is found on retinal axons that project into the lamina; this transported Spitz is required for lamina cartridge neuron differentiation
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\spi or the JBrowse view of Dmel\spi for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.48
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0081268
1653
234
FBtr0081269
1634
234
FBtr0081270
1438
234
FBtr0081267
1457
234
FBtr0100597
1576
234
Additional Transcript Data and Comments
Reported size (kB)
2.5, 2.0 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0080809
26.4
234
7.54
FBpp0080810
26.4
234
7.54
FBpp0080811
26.4
234
7.54
FBpp0080808
26.4
234
7.54
FBpp0100054
26.4
234
7.54
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

234 aa isoforms: spi-PA, spi-PB, spi-PE, spi-PF, spi-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
230 (aa); 26 (kD)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts with Star via the lumenal domain.
(UniProt, Q01083)
Post Translational Modification
Proteolytic processing by Rhomboid occurs in the Golgi. Cleavage takes place within the transmembrane domain close to residue 144 and the active growth factor is released. N-glycosylated and O-glycosylated.
(UniProt, Q01083)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\spi using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (29 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (23 terms)
Terms Based on Experimental Evidence (23 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:abd-A; FB:FBgn0000014
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
spi is expressed in small diploid cells located basally in the epithelium, which are likely intestinal stem cells.
spi is broadly expressed in the optic lobe.
spi transcript is expressed in the adult midgut precursor cells.
spi transcripts are expressed throughout development with a peak in mid-embryogenesis. In situ hybridizations show that spi is expressed ubiquitously in all embryonic tissues, with enrichment in the procephalic region, ventral midline, mesodermal layers, and PNS.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Expression of spi is highest in cone cells and bristle organules (interommatidial bristle precursors), and lower in the primary pigment cells.
The spi protein is expressed ubiquitously in embryos with slight enrichment in the mesoderm and the ventral midline.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\spi in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 51 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 44 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of spi
Transgenic constructs containing regulatory region of spi
Deletions and Duplications ( 25 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
anterior fascicle & synapse, with Scer\GAL4elav-C155
anterior fascicle & synapse | supernumerary, with Scer\GAL4elav-C155
bract & leg | ectopic, with Scer\GAL4sca-537.4
embryonic/first instar larval cuticle & denticle, with Scer\GAL4en-e16E
lamina & neuron
lamina & neuron, with Scer\GAL4hs.PB
larval sense organ & antennal segment
larval sense organ & maxillary segment
mesothoracic tarsal segment 1 & bract | ectopic, with Scer\GAL4sca-537.4
retina & basal lamina
sensory neuron & axon & embryo
taste bristle & leg | ectopic, with Scer\GAL4Dll-md23
taste bristle & leg | ectopic, with Scer\GAL4sca-537.4
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
 
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
1 of 15
Yes
Yes
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
1 of 13
Yes
Yes
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (3)
1 of 12
Yes
Yes
1 of 12
Yes
Yes
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (2)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190G6I )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150FG7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0JAH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0KPI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (2)
4 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 4 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
RNA-RNA
Physical Interaction
Assay
References
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
enhanceable
suppressible
suppressible
suppressible
External Data
Subunit Structure (UniProtKB)
Interacts with Star via the lumenal domain.
(UniProt, Q01083 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2L
Recombination map
2-54
Cytogenetic map
Sequence location
2L:19,567,900..19,577,315 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
37F2-37F2
Limits computationally determined from genome sequence between P{EP}EP623&P{PZ}spi01068 and P{lacW}l(2)k10239k10239
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
37F1-37F2
(determined by in situ hybridisation)
38A-38A
(determined by in situ hybridisation)
37F-38A
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (31)
Genomic Clones (13)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (189)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
Other clones
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
 
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of
Source for merge of: spi anon-WO0118547.158
Additional comments
Source for merge of spi anon-WO0118547.158 was sequence comparison ( date:051113 ).
Other Comments
Identified as a candidate gene for hypoxia-specific selection (via an experimental evolution paradigm) that is also differentially expressed between control and hypoxia-adapted larvae.
spi is not required for patterning of the dorsal anterior follicular epithelium.
S protein appears to traffic the spi precursor while cycling between the endoplasmic reticulum and late endosomes in S[[2]]R[+] cells.
spi protein is palimtoylated. Palmitoylation of spi promotes membrane association, increasing its activity but reducing its range.
spi is necessary for axon contact dependent inhibition of W dependent cell death of midline glial cells.
spi/Egfr signalling via the Ras/MAPK pathway mediates the induction of bract cell fate in the leg.
Area matching Drosophila EST AA201448. This EST forms a 856bp contig with ESTs AA438721 and AA247046.
spi interacts directly with S.
rho protein appears to be an intramembrane serine protease that directly cleaves spi protein. The putative rho active site is within the membrane bilayer and the spi cleavage site is within its transmembrane domain.
Two EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo.
hh and spi bring about the concerted assembly of ommatidial and synaptic cartridge units, imposing the "neurocrystalline" order of the compound eye onto the post-synaptic target field. spi activity is necessary and sufficient for the differentiation of cartridge neurons in the lamina.
EGF domain swapping experiments of vn, spi and argos demonstrate that the EGF domain is the key determinant that gives Egfr inhibitors and activators their distinct properties.
spi is required in follicle cells for dorsal-anterior patterning of the egg.
When spi is removed from the follicle cells using clonal analysis the dorsal appendages fuse. The phenotype resembles that caused by a reduction in Egfr signalling.
Epistasis tests with known dorsal/ventral patterning genes suggests that CrebA encodes a transcription factor near the end of both the dpp and spi signalling cascades to translate the corresponding extracellular signals into changes in gene expression.
In vivo culture of mutant discs from genotypes that are normally embryonic lethal demonstrates spi has no role in wing disc growth.
spi acts in photoreceptor recruitment in the developing retina.
The Egfr receptor pathway is activated by localized processing of the ligand spi in the tracheal placodes.
The function of spi, rho and S appears to be non-autonomous; expression of the precursor only in the midline is sufficient for patterning the ventral ectoderm.
Facilitating the expression of spi, rho and S is the only sim-dependent contribution of the midline to patterning the ventral ectoderm, since the mutant sim ectodermal defects can be overcome by expression of secreted spi in the ectoderm. These results suggest a mechanism for generating a graded distribution of secreted spi, which may subsequently give rise to graded activation of Egfr in the ectoderm.
The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to study the zygotic lethal mutation.
Mutations of spi, the putative ligand for Egfr in longitudinal vein formation, have no effect on penetrance of ectopic crossveins in chicgdh-5/EgfrE1 heterozygotes.
trh and the spi group of genes probably act in two separate pathways that are both necessary for proper salivary duct development.
In spi mutants the pre-duct cells are converted to a pre-gland fate.
In salivary gland development the activity of fkh prevents the expression of duct-specific cells, and in preduct cells the spi group signalling pathway prevents the expression of gland specific markers. fkh is repressed by spi group signalling, which is strongest in the most ventral cells of the epidermis.
The spi product triggers the Egfr signaling cascade. Graded activation of the Egfr pathway may normally give rise to a repertoire of discrete cell fates in the ventral ectoderm and graded distribution of spi may be responsible for the graded activation. The rho and S products may act as modulators of Egfr signaling. Epistatic relationships suggest that rho and S may normally facilitate processing of the spi precursor.
spi is required for photoreceptor determination; mutations modify the phenotype caused by ectopic expression of rho in the eye. Mosaic analysis suggest spi produces a diffusible signal during ommatidial development. Other members of the spi group and Egfr also interact with rho, in a pattern that suggests a model in which rho can act as a mediator of a ligand-receptor interaction between spi and Egfr in the developing eye.
Clonal analysis demonstrates spi is required in the founding photoreceptor cells.
Required for normal development of blastoderm cells just lateral to the ventral mesodermal precursors. spi+ required in the female germ line; spi- pole cells transplanted into normal embryos produce no progeny.
Embryonic lethal. Denticle bands narrower than normal; first row often missing; reversal of polarity between anterior and posterior rows not seen; irregular fusion in midline of adjacent dentical bands. Keilin's organs missing or strongly reduced. Labrum, antennal-maxillary complex and labial sense organ reduced in size; right and left halves of head skeleton fused to produce pointed appearance. Tail region normal. Right and left halves of ventral ganglia of the central nervous system closer together than normal resulting in shorter commissures. The cells in the CNS that stain with anti-eve+ antibodies are closer together in spi- than in wild type.
spi gene product is required for the proper development of the ventralmost cuticle and the CNS midline.
spi encodes a ligand that functionally interacts with the products of rho and possibly Egfr.
rho, pnt, S and spi all function in the formation of the same chordotonal organs.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 78 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
InterPro - A database of protein families, domains and functional sites
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (14)
Reported As
Symbol Synonym
anon-WO0118547.158
l(2)37Fa
spi
(Ben-Zvi and Volk, 2019, Chai et al., 2019, Meltzer et al., 2019, Moreno et al., 2019, Zhang et al., 2019, Kittelmann et al., 2018, Newcomb et al., 2018, Schwarz et al., 2018, Chabu et al., 2017, Kim et al., 2017, Louradour et al., 2017, Ozasa et al., 2017, Park et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Dubois et al., 2016, Jha et al., 2016, Jussen et al., 2016, Malartre, 2016, Sandler and Stathopoulos, 2016, Grotewiel and Bettinger, 2015, Kallsen et al., 2015, Kavi et al., 2015, Kim et al., 2015, Martín-Bermudo et al., 2015, Verhulst and van de Zande, 2015, Austin et al., 2014, Bischof and FlyORF project members, 2014.6.20, Kux and Pitsouli, 2014, Li et al., 2014, Luck et al., 2014, Zschätzsch et al., 2014, Handler et al., 2013, Handler et al., 2013, Hudson et al., 2013, Markstein, 2013, Sen et al., 2013, Shen et al., 2013, Shwartz et al., 2013, Walker et al., 2013, Webber et al., 2013, Butchar et al., 2012, Foronda et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Maeng et al., 2012, Murray et al., 2012, Peng et al., 2012, Reid et al., 2012, Rodriguez et al., 2012, Zoller and Schulz, 2012, Dworkin et al., 2011, Hwang and Rulifson, 2011, Jiang et al., 2011, Karim and Moore, 2011, Mirkovic et al., 2011, Murillo-Maldonado et al., 2011, Neumüller et al., 2011, Park et al., 2011, Roy et al., 2011, Sinenko et al., 2011, Sinenko et al., 2011, Zhang et al., 2011, Gutzwiller et al., 2010, Kitadate and Kobayashi, 2010, Liu et al., 2010, Morozova et al., 2010, Rousso et al., 2010, Salzer et al., 2010, Yogev et al., 2010, Yu et al., 2010, Corl et al., 2009, Dworkin et al., 2009, Fetting et al., 2009, Huh et al., 2009, Jiang and Edgar, 2009, Lachance et al., 2009, Maybeck and Röper, 2009, Oishi et al., 2009, Wheeler et al., 2009, Yan et al., 2009, Estes et al., 2008, Li-Kroeger et al., 2008, Escudero et al., 2007, Kim et al., 2007, Maeda et al., 2007, Magalhaes et al., 2007, Montrasio et al., 2007, Nishimura et al., 2007, Samsonova et al., 2007, Zhao et al., 2007, Brodu and Casanova, 2006, Dworkin and Gibson, 2006, Dworkin and Gibson., 2006, Liu et al., 2006, McDonald et al., 2006, Mirkovic and Mlodzik, 2006, Miura et al., 2006, Molnar et al., 2006, Oishi et al., 2006, Galindo et al., 2005, Laviolette et al., 2005, Stathopoulos and Levine, 2005, Brodu et al., 2004, Schlesinger et al., 2004, Chang et al., 2003, Chang et al., 2001, Lee et al., 1999)
Name Synonyms
epidermal growth factor protein
Secondary FlyBase IDs
  • FBgn0002048
  • FBgn0003474
  • FBgn0010472
  • FBgn0010690
  • FBgn0062206
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (681)