Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.47
3.4 (unknown); 6.1 (northern blot)
None of the polypeptides share 100% sequence identity.
1714 (aa); 189 (kD)
A multifunctional enzyme whose amino-terminal domain (domain I) includes a glutamyl-tRNA synthetase and whose carboxy-terminal domain (domain III) includes a prolyl-tRNA synthetase. These activities were confirmed by expression of domains I and III in E. coli and the demonstration of their ability to aminoacylate tRNA with glutamate and proline.
Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluProRS using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\GluProRS in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Area matching Drosophila glutamyl-prolyl-tRNA synthetase gene, Acc. No. U59923.
Intron exon organisation of Aats-glupro is determined and transcript analysis reveals two transcripts encode different proteins that are controlled by independent promoters. Transgenic lines overexpressing Aats-glupro show a dominant negative behaviour, competing in vivo with the endogenous partners of the complex, due to the central region containing the repeated motifs.