• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\dac

General Information
Symbol	Dmel\dac	Species	D. melanogaster
Name	dachshund	Annotation symbol	CG4952
Feature type	protein_coding_gene	FlyBase ID	FBgn0005677
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	dach, BG:DS02780.3, l(2)36Ae
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	36A1-36A2	Sequence location	2L:16,466,512..16,485,998 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dachshund is referred to in FlyBase by the symbol Dmel\dac (CG4952, FBgn0005677). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: axon guidance; compound eye photoreceptor development; compound eye development; negative regulation of gene expression; neuron differentiation; mushroom body development; photoreceptor cell fate specification; antennal joint development; genital disc sexually dimorphic development. 67 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; external compound sense organ; appendage segment; peripheral nervous system; imaginal precursor; integumentary specialisation; metathoracic metatarsus; cell part; mesothoracic femur; epithelial furrow. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: DNA binding domain, putative; Transforming protein Ski. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1633341_s_at completely aligns to an exonic region common to each of the 7 FlyBase-annotated transcript isoforms of dac. Gene sequence location is 2L:16466512..16485998.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Transgenic Constructs P{dac-lacZ.REDelta5} P{dac-lacZ.HI} P{dac-lacZ.RE.DeltaTAAT} P{dac-lacZ.RE.pan2-3} P{dac-lacZ.RE.Delta1-2TAAT} P{dac-lacZ.REDelta45Pan} P{dac-lacZ.RE} P{dac-lacZ.RE.Delta1-4TAAT} P{dac-lacZ.RE.pan1-2-3-7} P{dac-lacZ.RE.Delta5-6TAAT} P{dac-lacZ.RE.Mad1-7} P{dac-lacZ.REDelta45} P{dac-lacZ.RE.Delta5-10TAAT} P{dac-lacZ.RE.pan4-5-6} P{dac-lacZ.RE.pan1-7}
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 36A1-36A2   Limits computationally determined from genome sequence between P{EP}fzyEP1028&P{lacW}mRpL4k14608 and P{PZ}dacP
Experimentally Determined Cytological Location
Cytogenetic map Notes References 36A1-36A2   (determined by in situ hybridisation)   (Ashburner et al., 1999) 36A1-36A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 35F-36A   (determined by in situ hybridisation)   (Docquier et al., 1999) 36A1-36A2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dac for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dac-RA FBtr0080875  NM_165160   4955   1072 dac-RB FBtr0080876  NM_165162   4982   1081 dac-RC FBtr0080877  NM_165159   4934   1065 dac-RD FBtr0080878  NM_165161   4961   1074 dac-RF FBtr0100399  NM_001014487   4955   1072 dac-RG FBtr0100400  NM_001014486   4928   1063
Additional Transcript Data & Comments
Reported size (kB)	5 (northern blot) (Mardon et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dac-PA   FBpp0080432   112.6   1072   7.09     NP_723969   AAF53538 dac-PB   FBpp0080433   113.7   1081   7.14     NP_723971   AAN10944 dac-PC   FBpp0080434   111.8   1065   7.04     NP_723968   AAN10942 dac-PD   FBpp0080435   112.8   1074   7.09     NP_723970   AAN10943 dac-PF   FBpp0099813   112.7   1072   7.09     NP_001014487   AAX52668 dac-PG   FBpp0099814   111.6   1063   7.04     NP_001014486   AAX52667
Additional Polypeptide Data & Comments
Reported size (kDa)	1081, 1074, 1072, 1065 (aa) (Mardon et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transforming protein Ski (IPR003380) DNA binding domain, putative (IPR009061)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53538   AE014134 AAN10942   AE014134 AAN10943   AE014134 AAN10944   AE014134 AAX52667   AE014134 AAX52668   AE003416 AAF45019   AQ026135   BI376027   BI376122   BT010231 AAQ23549   BT030756   BT031177   CO261863   CO263516   CO278906   CO280207   CO286206   CO294902   CO295897   CO302087   CO304759   CO314497   CO316551   CO316944   CO324736   CO326816   CO332794   CO333911   CO339350   CO340084   CO340763   CO341774   EC059344   EC065738   EC066054   EC072691   EC089409   EC201176   EC201570   EC214190   EC216780   EC222960   EC228243   EC228738   EC230446   EC231332   EC234342   EC238536   EC246781   EC247596   EC255251   EC258909   GH951087   GH953415   GH954593   GH958855   GH961113   GH963665   GH965166   GH974472   GH979311   GH981465   U19269 AAC46506   U19269 AAC46507   U19269 AAC46508   U19269 AAC46509   U19269 AAC46510
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IP19 Q8IP20 Q8IP21 Q9VJK6 Q59DZ0 Q59DY9 Q24028 Q24030 Q6NR49 Q24029 Q24031 Q24027
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435041 2L:16,457,899..16,461,102 evidence=Reporter construct (in vivo) (Pfeiffer et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000435089 2L:16,461,520..16,461,713 evidence=Reporter construct (in vivo) (Pappu et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000435396 2L:16,454,480..16,457,690 evidence=Reporter construct (in vivo) (Pfeiffer et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000435520 2L:16,451,533..16,468,161 evidence=Reporter construct (in vivo) (Pappu et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000435782 2L:16,465,322..16,465,889 evidence=Reporter construct (in vivo) (Giorgianni and Mann, 2011, Halfon, 2012.6.19) regulatory region FBsf0000435837 2L:16,481,331..16,483,837 evidence=Reporter construct (in vivo) (Pfeiffer et al., 2008, Halfon, 2012.6.19) regulatory region FBsf0000435863 2L:16,486,073..16,487,275 evidence=Reporter construct (in vivo) (Jakobsen et al., 2007, Halfon, 2012.6.19) regulatory region FBsf0000436090 2L:16,461,324..16,461,713 evidence=Reporter construct (in vivo) (Pappu et al., 2005, Halfon, 2012.6.19) regulatory region FBsf0000436595 2L:16,469,685..16,471,421 evidence=Reporter construct (in vivo) (Pappu et al., 2005, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) clypeo-labral primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic central brain neuron   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) labral sensory complex   (Fisher et al., 2012) lateral cord glial cell   (Fisher et al., 2012) lateral cord neuron   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval central nervous system | restricted   (Mardon et al., 1994) embryonic stage 9 -- 11   procephalic neurogenic region & embryonic ocular segment | dorsal & restricted   (Urbach and Technau, 2003) protocerebral neuroblast | subset   (Urbach and Technau, 2003) tritocerebral neuroblast | subset   (Urbach and Technau, 2003) embryonic stage 9 -- 15   mushroom body primordium   • nucleus (Martini et al., 2000) embryonic stage 9 -- 16   mushroom body neuroblast   (Noveen et al., 2000) embryonic stage 9 -- 17   mushroom body   (Martini et al., 2000) embryonic stage 11   procephalic neurogenic region & embryonic protocerebrum | restricted   (Urbach and Technau, 2003) procephalic neurogenic region & embryonic antennal segment | dorsal & restricted   (Urbach and Technau, 2003) embryonic stage 15 -- larval stage   Tv neuron   (Baumgardt et al., 2007) larval stage   photoreceptor cell R6   (Mardon et al., 1994) haltere disc   (Mardon et al., 1994) photoreceptor cell R7   (Mardon et al., 1994) photoreceptor cell R1   (Mardon et al., 1994) cone cell   (Mardon et al., 1994) eye-antennal disc   (Mardon et al., 1994) optic lobe   (Mardon et al., 1994) ventral thoracic disc   (Mardon et al., 1994) Kenyon cell   (Kurusu et al., 2002) lamina furrow | posterior   (Poeck et al., 2001) lamina monopolar neuron | subset   (Poeck et al., 2001) lamina anlage | faint & restricted   (Poeck et al., 2001) embryonic/larval mushroom body   (Martini et al., 2000) first instar larval stage -- third instar larval stage   neuron of embryonic/larval mushroom body   • nucleus (Martini et al., 2000) second instar larval stage   Kenyon cell   (Noveen et al., 2000) third instar larval stage   embryonic/larval neuron | subset of medulla anlage   (Hasegawa et al., 2011) pupal stage   mushroom body   (Martini et al., 2000) pharate adult stage P8 -- P15   mushroom body intrinsic neuron   • nucleus (Martini et al., 2000) optic lobe   • nucleus (Martini et al., 2000) adult stage | male   organism   (Fabrizio et al., 2003) Comment:NOT testis adult stage   mushroom body intrinsic neuron   • nucleus (Martini et al., 2000) transmedullary neuron Tm9 | subset   (Hasegawa et al., 2011) distal medullary amacrine neuron Dm8a   (Hasegawa et al., 2011) distal medullary amacrine neuron Dm8b   (Hasegawa et al., 2011) adult mushroom body   (Martini et al., 2000)
Additional Descriptive Data
	dac protein is expressed in a subset of neurons of the medulla anlage in third instar larva. In adults, dac is expressed in the medulla neurons Tm9, Dm8a and Dm8b. (Hasegawa et al., 2011) dac protein is not detected in the male germline. (Fabrizio et al., 2003) dac protein is observed in mushroom body nuclei at 48, 72, and 96 hours after puparium formation. It is also evident in the area of the mushroom bodies in larvae at all stages and in embryos beginning at around stage 9. In adults, dac protein expression occurs in mushroom body neurons that are 8-10 hours old but not in neuroblasts, ganglion mother cells, or newly born neurons. (Martini et al., 2000) dac is expressed in a cluster of approximately 10-12 cells beginning at stage 9 of embryogenesis, which correspond to the mushroom body neuroblasts. Expression remains in the mushroom body ectoderm and mushroom body neuroblasts throughout embryogenesis. Expression expands to include a cluster of cells laterally adjacent to the mushroom body neuroectoderm, referred to as the 'para-MB neurectoderm'. At later stages of embryogenesis, expression is found in scattered groups of neurons in both the ventral nerve cord and brain, and other embryonic tissue. By stage 16 dac positive cells become incorporated into the brain. Levels of expression are noted to decline by embryogenesis stage 13. (Noveen et al., 2000) Expression in procephalic neuroblasts stage 9-11: tritocerebrum - v2; protocerebrum - av1, cd1, cd2, cd4, cd6, cd8, cd9, cd14, cv7, cv9, pd1, pd8, pd11 (Urbach and Technau, 2003) dac protein is expressed in imaginal discs in larvae. In the eye disc, it is expressed strongly in the unpatterned epithelium preceding the morphogenetic furrow. Posterior to the furrow, dac protein is expressed primarily in R1, R6, and R7 as well as in cone cells. dac protein is expressed only in the part of the eye disc that will become the retina. In leg discs, it is expressed in a ring pattern from a very early stage. It is also expressed in the third antennal disc segment and in wing discs. dac protein is also expressed in the embryonic CNS and in the optic lobe of the larval brain. (Mardon et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Mardon et al., 1994, Martini et al., 2000)
Expression Deduced from Reporters
Reporter: P{GawB}dacp7d23 Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   morphogenetic furrow | surrounding   (Chanut et al., 2002)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    362.225 Larval Midgut    5.6 Larval Hindgut    41.5 Larval Malpighian Tubules    232.7 Larval Fat Body    3.3 Larval Salivary Gland    5.8 Larval Trachea    8.55 Larval Carcass    22.1 Adult Head    59.4 Adult Eye    88.85 Adult Brain    281.8 Adult Thoracic-Abdominal Ganglion    92.8 Adult Crop    8.4 Adult Midgut    8.5 Adult Hindgut    44.5 Adult Malpighian Tubules    22.3 Adult Fat Body    13.2 Adult Salivary Gland    8.6 Adult Heart    3.7 Adult VirginFemale Spermatheca    23.9 Adult InseminatedFemale Spermatheca    34.6 Adult Ovary    0.4 Adult Testis    7.2 Adult Male Accessory Gland    4.5 Adult Carcass    20.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    59.4   NA  Eye    88.85   NA  Brain    281.8   362.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    92.8   NA  Crop    8.4   5.6  Midgut    8.5   41.5  Hindgut    44.5   232.7  Malpighian Tubules    no informative data   3.3  Fat Body    no informative data   5.8  Salivary Gland    8.6   NA  Heart    3.7   8.55  Trachea    NA   NA  VirginFemale Spermatheca    23.9   NA  InseminatedFemale Spermatheca    34.6   NA  Ovary    0.4   NA  Testis    7.2   NA  Male Accessory Gland    4.5   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (28) central nervous system, larvae L3  (30) central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  28 central nervous system, larvae L3  30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    28 central nervous system, larvae L3    30 central nervous system, pupae P8    16 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    3 head, mated 1-day female    4 head, mated 4-day female    4 head, mated 20-day female    4 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    6 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    6 carcass, larvae L3 wandering    16 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    5 embryo 10-12hr    6 embryo 12-14hr    7 embryo 14-16hr    9 embryo 16-18hr    9 embryo 18-20hr    9 embryo 20-22hr    7 embryo 22-24hr    7 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    9 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    10 white prepupae 24hr    15 pupae 2d postWPP    10 pupae 3d postWPP    4 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    4 adult male 30day    3 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    1 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    4 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    5 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    3 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    3 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	BDGP expression data • RE64054 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005677 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4952-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for dac Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4hs.PB dacScer\UAS.cSa lethal | recessive dacP Other Phenotypes Allele neuroanatomy defective dac3 visible dac3 visible, with Scer\GAL47B dacScer\UAS.cSa visible, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa visible, with Scer\GAL4ey.PH dacScer\UAS.cSa visible, with Scer\GAL4GMR.long dacScer\UAS.cSa visible, with Scer\GAL4ptc-559.1 dacScer\UAS.cSa visible | dominant dacMtlT5 visible | recessive dac9 dacP visible | recessive | somatic clone dac3 Phenotype manifest in Allele adult head, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa adult head, with Scer\GAL4ey.PH dacScer\UAS.cSa antenna, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa antenna, with Scer\GAL4ey.PH dacScer\UAS.cSa arista (with Df(2L)dac-4) dac3 bract | ectopic, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa clasper dac3 clasper long bristle dac3 clasper tooth dac3 ellipsoid body, with dac1/Df(2L)dac-4, Scer\GAL4ey-OK107 dac21.Scer\UAS ellipsoid body (with dac1) dac3 ellipsoid body (with dac3) dac1 ellipsoid body (with Df(2L)dac-4), with Scer\GAL4ey-OK107, dac21.Scer\UAS dac1 eye dac1 dac10BAL dac10FA3 dac12CN1 dac2 dac3 dac3BF1 dac3CX1 dac5 dac6 dac7 dac8 dacBDD1 dacP dacunspecified eye, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa eye, with Scer\GAL4ey.PH dacScer\UAS.cSa eye (with dac3) dacGAL4 eye (with dacGAL4) dac3 eye | ectopic, with Scer\GAL4dpp.blk1 dacScer\UAS.T:Ivir\HA1 dacScer\UAS.cSa eye | ectopic & adult head, with Scer\GAL4GMR.long dacScer\UAS.cSa eye | ectopic & female genitalia, with Scer\GAL47B dacScer\UAS.cSa eye-antennal disc dac1 dac3 dacP femur | somatic clone dac3 fifth segment of antenna (with Df(2L)dac-4) dac3 interommatidial bristle, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa joint, with Scer\GAL4ptc-559.1 dacScer\UAS.cSa joint | somatic clone dac3 lamina tangential neuron dac1 leg dac1 dac10BAL dac10FA3 dac12CN1 dac2 dac3 dac3BF1 dac3CX1 dac5 dac6 dac8 dac9 dacBDD1 dacP dacunspecified leg, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa leg, with Scer\GAL4ptc-559.1 dacScer\UAS.cSa leg | somatic clone dac3 mesothoracic femur dac1 dac3 mesothoracic metatarsus dac1 dac3 mesothoracic tarsal segment 2 dac1 dac3 mesothoracic tarsal segment 3 dac1 dac3 mesothoracic tibia dac1 dac3 metatarsus | ectopic dacMtlT5 metathoracic femur dac1 dac3 metathoracic metatarsus dac1 dac3 metathoracic tarsal segment 2 dac1 dac3 metathoracic tarsal segment 3 dac1 dac3 metathoracic tibia dac1 dac3 morphogenetic furrow dac1 dac3 dacP mushroom body dacP mushroom body, with Scer\GAL4238Y dacScer\UAS.cSa mushroom body (with dac1) dac3 mushroom body (with dac3) dac1 mushroom body (with Df(2L)dac-4) dac1 dac3 mushroom body alpha'-lobe dac3 mushroom body alpha-lobe dac3 mushroom body alpha-lobe (with dac1) dac3 mushroom body alpha-lobe (with dac3) dac1 mushroom body alpha-lobe (with Df(2L)dac-4) dac1 dac3 mushroom body alpha-lobe | larval stage (with dac1) dac3 mushroom body alpha-lobe | larval stage (with dac3) dac1 mushroom body alpha-lobe | larval stage (with Df(2L)dac-4) dac1 mushroom body alpha-lobe | somatic clone dac3 mushroom body beta'-lobe dac3 mushroom body beta'-lobe (with dac1) dac3 mushroom body beta'-lobe (with dac3) dac1 mushroom body beta'-lobe (with Df(2L)dac-4) dac1 dac3 mushroom body beta'-lobe | somatic clone dac3 mushroom body beta-lobe dac3 mushroom body beta-lobe (with dac1) dac3 mushroom body beta-lobe (with dac3) dac1 mushroom body beta-lobe (with Df(2L)dac-4) dac1 dac3 mushroom body beta-lobe | somatic clone dac3 mushroom body calyx (with dac1) dac3 mushroom body calyx (with dac3) dac1 mushroom body calyx (with Df(2L)dac-4) dac1 dac3 mushroom body gamma-lobe dac3 dacP mushroom body gamma-lobe, with dac1/Df(2L)dac-4, Scer\GAL4ey-OK107 dac21.Scer\UAS dac7C1.Scer\UAS mushroom body gamma-lobe, with dac3/Df(2L)dac-4, Scer\GAL4ey-OK107 dac7C1.Scer\UAS mushroom body gamma-lobe, with Scer\GAL4ey-OK107, dac1/dac3 dac7C1.Scer\UAS mushroom body gamma-lobe (with dac1) dac3 mushroom body gamma-lobe (with dac1), with Scer\GAL4ey-OK107, dac7C1.Scer\UAS dac3 mushroom body gamma-lobe (with dac3) dac1 mushroom body gamma-lobe (with dac3), with Scer\GAL4ey-OK107, dac7C1.Scer\UAS dac1 mushroom body gamma-lobe (with Df(2L)dac-4) dac1 dac3 mushroom body gamma-lobe (with Df(2L)dac-4), with Scer\GAL4ey-OK107, dac7C1.Scer\UAS dac1 dac3 mushroom body gamma-lobe (with Df(2L)dac-4), with Scer\GAL4ey-OK107, dac21.Scer\UAS dac1 mushroom body gamma-lobe | somatic clone dac3 mushroom body spur (with dac1) dac3 mushroom body spur (with dac3) dac1 mushroom body spur (with Df(2L)dac-4) dac3 ommatidium dac1 dac3BF1 dacP dacunspecified ommatidium, with Scer\GAL4ey.PH dacScer\UAS.cSa ommatidium (with dac3) dacGAL4 ommatidium (with dacGAL4) dac3 photoreceptor cell R1 dac1 dacP photoreceptor cell R2 dac1 dacP photoreceptor cell R3 dac1 dacP photoreceptor cell R4 dac1 dacP photoreceptor cell R5 dac1 dacP photoreceptor cell R6 dac1 dacP photoreceptor cell R7 dac1 dacP photoreceptor cell R8 dac1 dacP prothoracic femur dac1 dac3 prothoracic leg & sex comb dacMtlT5 prothoracic metatarsus dac1 dac3 prothoracic tarsal segment 2 dac1 dac3 prothoracic tarsal segment 3 dac1 dac3 prothoracic tibia dac1 dac3 rhabdomere, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa sex comb | ectopic dacMtlT5 spermathecal duct dac3 tarsal segment 2 dacMtlT5 tarsal segment | somatic clone dac3 tibia | somatic clone dac3 ventral thoracic disc dac1 dac3 ventral thoracic disc | anterior/posterior compartment boundary, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa wing, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa wing disc | anterior/posterior compartment boundary, with Scer\GAL4dpp.blk1 dacScer\UAS.cSa
Classical Alleles ( 37 )
For All Classical Alleles Show
Allele of dac Class Mutagen Stocks Known lesion dac1 loss of function allele, amorphic allele - genetic evidence 2 Yes dac9 hypomorphic allele - genetic evidence 2 -- dac3 amorphic allele - genetic evidence, loss of function allele 1 Yes dacd02520 1 -- dacE462 1 -- dacMB02724 1 -- dacP hypomorphic allele - genetic evidence P-element activity 1 Yes dacPyR34a P-element activity 1 Yes dacMtl40 amorphic allele - genetic evidence P-element activity Delta2-3 0 Yes dac10BAL 0 Yes dac10FA3 hypomorphic allele - genetic evidence 0 Yes dac12CN1 0 Yes dac2 hypomorphic allele - genetic evidence 0 Yes dac3BF1 hypomorphic allele - genetic evidence 0 Yes dac3CX1 0 Yes dac5 hypomorphic allele - genetic evidence 0 Yes dac6 hypomorphic allele - genetic evidence 0 Yes dac7 hypomorphic allele - genetic evidence 0 -- dac8 hypomorphic allele - genetic evidence 0 Yes dacBDD1 0 Yes dacGAL4 Delta2-3 0 Yes dacMEE-2 ethyl methanesulfonate 0 Yes dacMHE-1 ethyl methanesulfonate 0 Yes dacMtlT5 antimorphic allele - genetic evidence P-element activity 0 -- dacp7d23 loss of function allele P-element activity 0 -- dacPG gene conversion 0 Yes dacSFE-8 ethyl methanesulfonate 0 Yes dacT5-101 Delta2-3 0 Yes dacT5-17 Delta2-3 0 Yes dacT5-1 Delta2-3 0 Yes dacT5-2 Delta2-3 0 Yes dacT5-3 Delta2-3 0 Yes dacT5-4 Delta2-3 0 Yes dacT5-5 Delta2-3 0 Yes dacT5-6 Delta2-3 0 Yes dacT5-7 Delta2-3 0 Yes dacunspecified 0 --
Alleles Carried on Transgenic Constructs ( 30 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dac Class Mutagen Stocks Known lesion dacGD1414 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dacHMS01435 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dacJF02322 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dacT:Avic\GFP-SF,T:Zzzz\FLAG,T:Zzzz\PSP.CS,T:Zzzz\TEV.CS,T:Zzzz\BLRP in vitro construct - coding region fusion 1 Yes dac21.Scer\UAS in vitro construct - regulatory fusion 0 Yes dac7C1.Scer\UAS in vitro construct - regulatory fusion 0 Yes dacDD1.DD2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacDD1.Scer\UAS.3x.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes dacDD1.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacDD2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacDD31.Scer\UAS in vitro construct - coding region fusion in vitro construct - deletion 0 Yes dacN.DD1.DD2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacN.DD1.M.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacN.DD1.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacN.DD2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacN.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacNIG.4952R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dacNLS1.Scer\UAS.3x.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes dacNLS2.Scer\UAS.3x.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes dacScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes dacScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dacStinger.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dacΔC.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔDD1.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔDD1.ΔDD2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔDD2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔM.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔM.ΔNLS2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔN.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes dacΔNLS2.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A72 (Ashburner et al., 1990) Df(2L)A267 (Ashburner et al., 1990) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)k08106-rv4 (Roote, 2000.6.13) Df(2L)k08106-rv6 (Roote, 1999.7.7, Roote, 2000.6.13) Df(2L)k08106-rv15 (Roote, 1999.7.7, Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)RA5 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv16 (Ashburner et al., 1990) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990) Df(2L)Scorv25 (Ashburner et al., 1990) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-34 (Ashburner et al., 1990) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-13 (Ashburner et al., 1990) Df(2L)TE35D-14 (Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)TE35D-22 (Ashburner et al., 1990) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Ashburner et al., 1990) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990)
Disrupted in	Df(2L)cact-255rv64 (Spradling et al., 1999, Tower et al., 1993, BDGP Project Members, 1994-1999, Roote, 1996.1.11, Roote, 1996.8) Df(2L)dac-4 (Mardon et al., 1994) Df(2L)Exel7065 (Ryder, 2004.4.26) Df(2L)Exel7066 (Ryder, 2004.4.26) Df(2L)r10 (Ashraf et al., 1999, Ashburner et al., 1990, BDGP Project Members, 1994-1999) Df(2L)RI1 (Ashraf et al., 1999) Df(2L)RM5 (Ashraf et al., 1999, Ashburner et al., 1990) Df(2L)RN2 (Ashburner et al., 1990, Roote, 1995.3.24) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990)
Duplicated in	Dp(2;3)osp3 (Ashburner et al., 1990)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1414} NA P{NIG.4952R} NA P{TRiP.HMS01435} NA P{TRiP.JF02322} NA P{UAS-3xEGFP.dac.NLS1} NA P{UAS-3xEGFP.dac.NLS2} NA P{UAS-dac.7C1} NA P{UAS-dac.21} NA P{UAS-dac.DD1.DD2.HA} NA P{UAS-dac.DD1.HA} NA P{UAS-dac.DD2.HA} NA P{UAS-dac.DD31} NA P{UAS-dac.HA} NA P{UAS-dac.N.DD1.DD2.HA} NA P{UAS-dac.N.DD1.HA} NA P{UAS-dac.N.DD1.M.HA} NA P{UAS-dac.N.DD2.HA} NA P{UAS-dac.N.HA} NA P{UAS-dac.S} NA P{UAS-dac.ΔC.HA} NA P{UAS-dac.ΔDD1.HA} NA P{UAS-dac.ΔDD1.ΔDD2.HA} NA P{UAS-dac.ΔDD2.HA} NA P{UAS-dac.ΔM.HA} NA P{UAS-dac.ΔM.ΔNLS2.HA} NA P{UAS-dac.ΔN.HA} NA P{UAS-dac.ΔNLS2.HA} NA GAL4 construct P{GMR9B04-GAL4} No P{GMR9B05-GAL4} No P{GMR9B06-GAL4} No P{GMR9B07-GAL4} No P{GMR9B08-GAL4} No P{GMR9B09-GAL4} No P{GMR9B10-GAL4} No P{GMR9C02-GAL4} No P{GMR9C06-GAL4} No P{GMR9C07-GAL4} No P{GMR9C08-GAL4} No P{GMR9C09-GAL4} No P{GMR9C10-GAL4} No P{GMR9C11-GAL4} No P{GMR9C12-GAL4} No P{GMR9D02-GAL4} No P{GMR62A03-GAL4.EP} No PBac{dac-GAL4.R9C11} No reporter construct P{CaSpeR-dac.3EE.0.39kb-βgal} No P{CaSpeR-dac.3EE.0.85kb-βgal} No P{CaSpeR-dac.3EE.0.659kb-βgal} No P{CaSpeR-dac.16.6kb-βgal} No P{CaSpeR-dac.S1mut.3EE.0.194kb-betagal} No P{dac-lacZ.HI} No P{dac-lacZ.RE.Mad1-7} No P{dac-lacZ.RE.pan1-2-3-7} No P{dac-lacZ.RE.pan1-7} No P{dac-lacZ.RE.pan2-3} No P{dac-lacZ.RE.pan4-5-6} No P{dac-lacZ.RE.Δ1-2TAAT} No P{dac-lacZ.RE.Δ1-4TAAT} No P{dac-lacZ.RE.Δ5-6TAAT} No P{dac-lacZ.RE.Δ5-10TAAT} No P{dac-lacZ.RE.ΔTAAT} No P{dac-lacZ.RE} No P{dac-lacZ.REΔ5} No P{dac-lacZ.REΔ45} No P{dac-lacZ.REΔ45Pan} No characterization construct P{dac-FLP.325} NA P{dac-LexA::p65.R9C11} NA P{dac-LexA::VP16.R9B05} NA P{dac-LexA::VP16.R9C11} NA P{dac-nlsLexA::p65.R9B05} NA P{dac-nlsLexA::p65.R9C11} NA P{H-Stinger.HA-dac} NA P{UAS-DD31::CD556} NA PBac{dac-GFP.FPTB} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PyR}dacPyR34a No P{PZ}dacP No insertion of mobile activating element P{GSV1}C877C877 NA P{XP}dacd02520 NA miscellaneous insertions P{35UZ}dacMtlT5 NA P{?35UZ}dacT5-1 NA P{?35UZ}dacT5-2 NA P{?35UZ}dacT5-3 NA P{?35UZ}dacT5-4 NA P{?35UZ}dacT5-5 NA P{?35UZ}dacT5-6 NA P{?35UZ}dacT5-7 NA P{?35UZ}dacT5-17 NA P{?35UZ}dacT5-101 NA insertion of enhancer trap binary system Mi{ET1}dacMB02724 No P{GawB}dacGAL4 No P{GawB}dacp7d23 No P{GawB}dacPG No
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:Q9VBW6 (assigned by UniProtKB) (Curtiss et al., 2007) inferred from physical interaction with UniProtKB:Q9VBW9 (assigned by UniProtKB) (Curtiss et al., 2007)
Biological Process
CV term Evidence References
antennal joint development inferred from mutant phenotype (Dong et al., 2002) axon guidance inferred from mutant phenotype (Martini and Davis, 2005) compound eye development inferred from mutant phenotype (Pappu et al., 2005) compound eye photoreceptor development inferred from mutant phenotype (Tavsanli et al., 2004) genital disc sexually dimorphic development inferred from mutant phenotype (Keisman and Baker, 2001) mushroom body development inferred from expression pattern AND inferred from mutant phenotype (Noveen et al., 2000) inferred from mutant phenotype (Martini et al., 2000, Martini and Davis, 2005) negative regulation of gene expression inferred from mutant phenotype (Abu-Shaar and Mann, 1998) neuron differentiation inferred from mutant phenotype (Chotard et al., 2005) photoreceptor cell fate specification inferred from mutant phenotype (Anderson et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Mardon et al., 1994, Martini et al., 2000)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
nucleotide binding inferred from electronic annotation with InterPro:IPR009061 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
genital disc development traceable author statement (Sanchez and Guerrero, 2001) genital disc morphogenesis traceable author statement (Christiansen et al., 2002) leg disc proximal/distal pattern formation traceable author statement (Marsh and Theisen, 1999, Milan and Cohen, 2000, Mann and Casares, 2002) spermathecum morphogenesis traceable author statement (Qazi et al., 2003) transcription, DNA-dependent traceable author statement (Martini et al., 2000)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Mardon, 1994.12.30)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dac - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dac - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dac - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dac - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dac - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dac - dan anti bait coimmunoprecipitation, western blot (Hoang et al., 2010) dac - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dac allele Gene References dac2 Egfr (Mardon et al., 1994) dac5 Egfr (Mardon et al., 1994) dac6 Egfr (Mardon et al., 1994) dac7 Egfr (Mardon et al., 1994) dacP ey (Martini et al., 2000) hh (Mardon et al., 1994) peb (Wilk et al., 2004) dacScer\UAS.cSa CycE (Jiao et al., 2001) dm (Jiao et al., 2001) dpp (Curtiss and Mlodzik, 2000) ey (Chen et al., 1999) eya (Chen et al., 1997, Bui et al., 2000) dacΔC.Scer\UAS.T:Ivir\HA1 eya (Tavsanli et al., 2004) dacΔDD1.Scer\UAS.T:Ivir\HA1 eya (Tavsanli et al., 2004) dacΔDD2.Scer\UAS.T:Ivir\HA1 eya (Tavsanli et al., 2004) dacΔM.Scer\UAS.T:Ivir\HA1 eya (Tavsanli et al., 2004) unspecified Egfr (Mardon et al., 1994) eya (Hsiao et al., 2001, Tavsanli et al., 2004) Psn (Mahoney et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60991 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005677 DroID - A comprehensive database of gene and protein interactions. • FBgn0005677 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34982
Orthologs
OrthoDB Orthologs (136) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BRX4Z Dipteran inclusive ortholog search EOG6GXFVN Insect inclusive ortholog search EOG6547TC Arthropod inclusive ortholog search EOG64XGXK Metazoa inclusive ortholog search EOG6RZ9RS
Orthologs in Drosophila Species (EOG6BRX4Z)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\e(y)3     Drosophila melanogaster fruit fly  Dmel\CG32676     Drosophila melanogaster fruit fly  Dmel\dac     Drosophila melanogaster fruit fly  Dmel\tyf     Drosophila melanogaster fruit fly  Dmel\Cpr64Ad     Drosophila melanogaster fruit fly  Dmel\CG10915     Drosophila melanogaster fruit fly  Dmel\RhoGAP19D     Drosophila melanogaster fruit fly  Dmel\CG43349     Drosophila melanogaster fruit fly  Dmel\dp     Drosophila melanogaster fruit fly  Dmel\CG32603     Drosophila melanogaster fruit fly  Dmel\nocte     Drosophila melanogaster fruit fly  Dmel\elav     Drosophila melanogaster fruit fly  Dmel\CG7300     Drosophila melanogaster fruit fly  Dmel\NFAT     Drosophila melanogaster fruit fly  Dmel\bif     Drosophila melanogaster fruit fly  Dmel\Aef1     Drosophila melanogaster fruit fly  Dmel\CG16711     Drosophila melanogaster fruit fly  Dmel\Vsx1     Drosophila melanogaster fruit fly  Dmel\sbb     Drosophila melanogaster fruit fly  Dmel\CG30069     Drosophila melanogaster fruit fly  Dmel\sens-2     Drosophila melanogaster fruit fly  Dmel\CG8157     Drosophila melanogaster fruit fly  Dmel\Muc12Ea     Drosophila melanogaster fruit fly  Dmel\Samuel     Drosophila melanogaster fruit fly  Dmel\CG15894     Drosophila melanogaster fruit fly  Dmel\CG32767     Drosophila simulans   Dsim\GD22700   Y Drosophila erecta   Dere\GG24368   Y Drosophila yakuba   Dyak\GE14706   Y Drosophila ananassae   Dana\GF23960   Y Drosophila pseudoobscura pseudoobscura   Dpse\GA26108   Y Drosophila persimilis   Dper\GL14154   Y Drosophila virilis   Dvir\GJ17387   Y Drosophila mojavensis   Dmoj\GI17886   Y Drosophila grimshawi   Dgri\GH13743   Y
Orthologs in non-Drosophila Dipterans (EOG6GXFVN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012909 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000819 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012905 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009265 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010021 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010024 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013285 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005058 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004536 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012484 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015316 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007969 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002709 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007483 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015312 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015311 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006893 Y
Orthologs in non-Dipteran Insects (EOG6547TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41255 Y Apis mellifera Western honey bee  Amel\GB43208 Y Apis mellifera Western honey bee  Amel\GB43666 Y Apis mellifera Western honey bee  Amel\CPR2 Y Apis mellifera Western honey bee  Amel\GB52999 Y Apis mellifera Western honey bee  Amel\LOC551587 Y Apis mellifera Western honey bee  Amel\GB55781 Y Apis mellifera Western honey bee  Amel\GB42621 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004953 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG036228 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008772 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004406 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000786 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006740 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG035759 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009060 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG034456 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013086 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG027795 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG032807 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008673 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG016473 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004397 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005049 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001062 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004225 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008627 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG029848 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014054 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008994 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007076 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14778 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14777 Y Atta cephalotes Leafcutter ant  Acep\ACEP23948 Y Atta cephalotes Leafcutter ant  Acep\ACEP23943 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO16689 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12372 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12371 Y Linepithema humile Argentine ant  Lhum\LH24821 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB25725 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27161 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27158 Y Solenopsis invicta Red fire ant  Sinv\SINV24596 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI060717 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001358 Y Bombyx mori Silkmoth  Bmor\CPG33 Y Bombyx mori Silkmoth  Bmor\BGIBMGA003481 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011157 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006856 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007313 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010134 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002715 Y Bombyx mori Silkmoth  Bmor\BGIBMGA001620 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012308 Y Bombyx mori Silkmoth  Bmor\BGIBMGA005012 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014578 Y Tribolium castaneum Red flour beetle  Tcas\TC011986 Y Tribolium castaneum Red flour beetle  Tcas\TC009709 Y Tribolium castaneum Red flour beetle  Tcas\Ubx Y Tribolium castaneum Red flour beetle  Tcas\TC011154 Y Tribolium castaneum Red flour beetle  Tcas\TC013169 Y
Orthologs in non-Insect Arthropods (EOG64XGXK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\petN Y Daphnia pulex Water flea  Dpux\JGI_V11_332869 Y Ixodes scapularis Deer tick  Isca\ISCW020313 Y
Orthologs in non-Arthropod Metazoa (EOG6RZ9RS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014572gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026550gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006001gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006000gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016681gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004895gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024374gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015008gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020905gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018275gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019854gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016807gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026651gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021044gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027006gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004845gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016555gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026649gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021866gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020968gn Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21910 Drosophila sechellia Dsec\GM17175 Drosophila erecta Dere\GG20126 Drosophila yakuba Dyak\GE12814 Drosophila ananassae Dana\GF15881 Drosophila pseudoobscura pseudoobscura Dpse\GA18550 Drosophila persimilis Dper\GL18480 Drosophila willistoni Dwil\GK24323 Drosophila virilis Dvir\GJ17453 Drosophila mojavensis Dmoj\GI13824 Drosophila grimshawi Dgri\GH25029
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	12047 P{PZ}dacP/CyO; ry506 24027 w1118; Mi{ET1}dacMB02724 6337 w*; dacE462 P{neoFRT}40A/CyO 6109 dac9 pksple-3/CyO, Df(2R)cn-S3 28290 w*; dac3 P{neoFRT}40A/CyO, P{ActGFP}JMR1 35022 y1 sc* v1; P{TRiP.HMS01435}attP2 42269 w1118; PBac{dac-GFP.FPTB}VK00033/TM3, Sb1 26758 y1 v1; P{TRiP.JF02322}attP2/TM3, Sb1
Harvard	- P{XP}dacd02520
Kyoto	108609 dac9 pksple-3/CyO, Df(2R)cn-S3 109135 y1 w67c23; P{PyR}dacPyR34a / CyO, P{en1}wgen11
VDRC	v2942 w1118; P{GD1414}v2942
	More stocks available...
Genomic Clones ( 2 )
	BACR33A07 BACR44N04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 54 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14140 AT18265 RE64054
Other clones	DPiM_RE64054
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE63947
Other clones	18849 53196 55007 66663 72534 78411 79960 117338 122880 147638 161383 161986 214383.33 214471.25 277524 282463 CK01.80A.E8 CK01.106B.E7 CK01.117D.H1 EK062052 EK080920 EK088720 EK132250 EK153404 EK183028 EK194653 EK207937 EK212124 EK236710 EK246056 EK265244 EK266342 EK304552 EK308325 EP01650 EP04705 EP10007 EP11309 EP13127 RP004021163 RP004112193 RP004130137 RP004166334 RP004231606 RP004252426 RP004363043 RP004494464 RP004512082 RP004538644
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005677 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34982
Antibody Information
	monoclonal (Mardon et al., 1994)
Other Information
Discoverer
Etymology
	Some mutant alleles produce escapers with crippled legs (hence the name "dachshund"). (Ashburner et al., 1999) The gene is named "dachshund" after the mutant phenotype; mutant flies have short, little legs. (Mardon et al., 1994)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dac CG4952 (Kodira, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dac is necessary to upregulate and maintain Egfr expression in lamina neurons. (Chotard et al., 2005) The 5' eye enhancer region located in intron 8 is primarily regulated by ey, although this regulation also requires eya and so. By contrast, the 3' eye enhancer is regulated by a combination of eya, so and dpp signaling, but is not directly dependent upon ey. (Pappu et al., 2005) dac is essential for proper joint formation between antennal segment 5 and the arista. (Dong et al., 2002) dac plays sex-specific roles in the development of the genitalia. (Keisman and Baker, 2001) dac has a function in the structural development of the mushroom body. (Kurusu et al., 2000) dac is required autonomously within the mushroom body (MB) for three major aspects of MB cell differentiation; it is required for MB neurites to respect their normal neuropil borders, for axons to arrange themselves properly within the horizontal (β, β' and γ) lobes and for MB axons to be able to fill the α lobe neuropil properly. (Martini et al., 2000) ey and dac do not seem to regulate each other's expression in the developing mushroom body. (Noveen et al., 2000) ey and dac may have a role in axon pathway selection during embryogenesis. (Noveen et al., 2000) dac and eya act synergistically to induce ectopic retinal development and positively regulate the expression of each other. (Chen et al., 1997) Targeted expression of dac is sufficient to direct ectopic retinal development in a variety of tissues, including the adult head, thorax and legs. dac and ey induce the expression of each other and dac is required for ectopic retinal development driven by ey misexpression. Results suggest dac and ey are likely to function together in the control of retinal cell-fate specification at the early stages of eye development. (Shen and Mardon, 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_165159 NM_165160 NM_165161 NM_165162 NM_001014486 NM_001014487 RefSeq (Proteins) • NP_723968 NP_723969 NP_723970 NP_723971 NP_001014486 NP_001014487 DDBJ / EMBL / GenBank • AAC46506 AAC46507 AAC46508 AAC46509 AAC46510 AAF45019 AAF53538 AAF53538.3 AAN10942 AAN10942.1 AAN10943 AAN10943.1 AAN10944 AAN10944.1 AAN10945 AAN10945.1 AAQ23549 AAX52667 AAX52668 AE003416 AQ026135 BI376122 BT010231 U19269 Entrez Gene - A searchable database of RefSeq genes. • 34982 UniProtKB/TrEMBL • Q6NR49 Q8IP19 Q8IP20 Q8IP21 Q9VJK6 Q59DY9 Q59DZ0 Q24027 Q24028 Q24029 Q24030 Q24031
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transforming protein Ski (IPR003380) DNA binding domain, putative (IPR009061) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE64054
Linkouts
	BioGRID - A database of protein and genetic interactions • 60991 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0005677 DroID - A comprehensive database of gene and protein interactions. • FBgn0005677 DRSC - Results from RNAi screens. • FBgn0005677 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005677 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4952-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005677 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34982 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34982 modMine - Data generated by the modENCODE project. • FBgn0005677 REDfly - A database of transcriptional regulatory elements. • FBgn0005677
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	BG:DS02780.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4952 (Metaxakis et al., 2005, Molnar et al., 2006, Datta et al., 2011, Perkins et al., 2009.3.31, Ni et al., 2011.7.19) DAC (Yoshida et al., 2005, Datta et al., 2011, Dey et al., 2009, Erclik et al., 2008, Datta et al., 2009, Sawamura et al., 2008, Kosmidis et al., 2010) Dac (Dominguez et al., 2004, Gorfinkiel et al., 1999, Baumgardt et al., 2007, Ekas et al., 2006, Zhang et al., 2005, Babu et al., 2005, Kozu et al., 2006, Mishra and Nigam, 2007, Baumgardt et al., 2009, Kawamori et al., 2011, Zhang et al., 2011, Yogev et al., 2010, Estella and Mann, 2010, Hwang and Rulifson, 2011, Sugie et al., 2010, Chu et al., 2006, Yasugi et al., 2008, Barrio et al., 2007, Bannina and Kopp, 2007, Jemc and Rebay, 2007, Lee et al., 2009, McKay et al., 2009, Wang et al., 2008, Peng et al., 2009, Brás-Pereira and Casares, 2008, Zhang et al., 2009, Nishimura et al., 2008, Kaminker et al., 2002, Wang et al., 2011, Hasegawa et al., 2011, Kim et al., 2009, Schuldiner et al., 2008, Yasugi et al., 2010, Olson et al., 2011, Oyallon et al., 2012, Kosmidis et al., 2010, Plavicki et al., 2012, Dearborn et al., 2012) dac (Urbach et al., 2006, Kumar and Luhur, 2007, Estella and Mann, 2007, Baumgardt et al., 2007, Kumar and Salzer, 2007, Kumar and Datta, 2007, Kumar and Anderson, 2007, Noro et al., 2006, Umetsu et al., 2006, Chotard et al., 2005, Stevens and Mann, 2007, Mahoney et al., 2006, Culi et al., 2006, Roederer et al., 2005, Wallace et al., 2000, Randsholt, 2007, Ebacher et al., 2007, Friedrich, 2006, Jones, 2007, Joulia et al., 2006, Akimoto et al., 2005, Silver et al., 2003, Duong et al., 2008, Martini and Davis, 2005, Jakobsen et al., 2007, Herrero et al., 2007, Estella and Mann, 2010, Salzer and Kumar, 2008, Baumgardt et al., 2008, Anderson and Kumar, 2008, Molnar et al., 2006, Halachmi et al., 2007, Datta et al., 2011, Wang et al., 2007, Datta et al., 2011, Giorgianni and Mann, 2011, Loncle et al., 2007, Emmons et al., 2007, Patel et al., 2007, Estella and Mann, 2008, Lebreton et al., 2008, Weasner et al., 2007, Tanaka-Matakatsu and Du, 2008, Kim et al., 2008, Pfeiffer et al., 2008, Pueyo and Couso, 2008, Salzer and Kumar, 2009, Firth and Baker, 2009, Curtiss et al., 2007, Braid and Verheyen, 2008, Kurusu et al., 2009, Choi et al., 2005, Greenberg and Hatini, 2009, Furukubo-Tokunaga et al., 2009, Houl et al., 2008, Salzer et al., 2010, Salzer and Kumar, 2010, Karlsson et al., 2010, Lemons et al., 2010, Losada-Pérez et al., 2010, Céspedes et al., 2010, Wang et al., 2010, Bosch et al., 2010, Royo et al., 2011, Chatterjee et al., 2011, Oros et al., 2010, Ahn et al., 2011, Randsholt and Santamaria, 2008, Sprecher et al., 2007, Gutiérrez et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Morillo et al., 2012, Nfonsam et al., 2012, Kunz et al., 2012, Galindo et al., 2011, Manning et al., 2012, Spokony and White, 2012.11.14) Dac2-3 (Leal et al., 2009) dach (Kawakami et al., 2000) Dach (Zhu et al., 2008) Dm-DAC (Prpic et al., 2003) l(2)36Ae (Ashburner et al., 1999, Ashburner et al., 1990, ) l(2)rK364   spn
Name Synonym	Dachshund (Kaplow et al., 2008, Zhang et al., 2005, Baumgardt et al., 2009, Zhu et al., 2008, Barrio et al., 2007, Curtiss et al., 2007, Leal et al., 2009, Losada-Pérez et al., 2010, Wang et al., 2011, Sawamura et al., 2008, Oyallon et al., 2012, Jepson et al., 2011) dachshund (Mardon, 1994.12.30, Kumar and Luhur, 2007, Kumar and Salzer, 2007, Kumar and Datta, 2007, Kumar and Anderson, 2007, Noro et al., 2006, Roederer et al., 2005, Hoopfer et al., 2008, Randsholt, 2007, Fernald, 2006, Ebacher et al., 2007, Anderson et al., 2006, Akimoto et al., 2005, Silver et al., 2003, Duong et al., 2008, Martini and Davis, 2005, Jakobsen et al., 2007, Herrero et al., 2007, Estella and Mann, 2010, Lee et al., 2007, Ulvklo et al., 2008, Lesly and Kumar, 2008, Halachmi et al., 2007, Dey et al., 2009, Wang et al., 2007, Loncle et al., 2007, Emmons et al., 2007, Patel et al., 2007, Estella and Mann, 2008, Lebreton et al., 2008, Bannina and Kopp, 2007, Kim et al., 2008, Pfeiffer et al., 2008, Kurusu et al., 2009, Greenberg and Hatini, 2009, Salzer et al., 2010, Salzer and Kumar, 2010, Lemons et al., 2010, Wang et al., 2010, Royo et al., 2011, Ahn et al., 2011, Sprecher et al., 2007, Giorgianni and Mann, 2011, Dearborn et al., 2012) DACHSHUND (Erclik et al., 2008, Furukubo-Tokunaga et al., 2009, Houl et al., 2008) dachsund (Tower et al., 1993, Estella and Mann, 2007, Takaesu et al., 2006) dacshund (Garvey et al., 2005, Butler et al., 2005, Friedrich, 2006, Oros et al., 2010) daschund (Jones, 2007) spinosus
Secondary FlyBase IDs
References ( 390 )
Generate a list of	All references relating to this gene ( 390 )
List References by type	Research paper  ( 231 ) Supplementary material  ( 10 ) Review  ( 57 ) Personal communication to FlyBase  ( 22 ) Abstract  ( 61 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Website  ( 1 ) Conference report  ( 1 )
Recent research papers ( 28 )
	Ing et al., 2013, Dev. Biol. 373(2): 290--299 Sp1 modifies leg-to-wing transdetermination in Drosophila. [FBrf0220392] Dearborn et al., 2012, PLoS ONE 7(5): e37303 Reph, a Regulator of Eph Receptor Expression in the Drosophila melanogaster Optic Lobe. [FBrf0218347] Eade et al., 2012, PLoS Genet. 8(2): e1002501 Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system. [FBrf0217668] Gutiérrez et al., 2012, Development 139(1): 117--127 The role of the histone H2A ubiquitinase Sce in Polycomb repression. [FBrf0216868] Henry et al., 2012, Nucleic Acids Res. 40(19): 9691--9704 Cell type-specific genomics of Drosophila neurons. [FBrf0219710] Kunz et al., 2012, Development 139(14): 2510--2522 Origin of Drosophila mushroom body neuroblasts and generation of divergent embryonic lineages. [FBrf0218649] Manning et al., 2012, Cell Rep. 2(4): 1002--1013 A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. [FBrf0219785] Morillo et al., 2012, Dev. Biol. 365(1): 267--276 Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. [FBrf0218012] Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Okamoto et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(7): 2406--2411 Conserved role for the Dachshund protein with Drosophila Pax6 homolog Eyeless in insulin expression. [FBrf0217470] Oyallon et al., 2012, Dev. Biol. 369(2): 261--276 Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors. [FBrf0219228] Plavicki et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(5): 1578--1583 Homeobox gene distal-less is required for neuronal differentiation and neurite outgrowth in the Drosophila olfactory system. [FBrf0217395] Song et al., 2012, Dev. Cell 22(2): 363--376 Determinants of the Drosophila odorant receptor pattern. [FBrf0217536] Ahn et al., 2011, Dev. Biol. 355(2): 336--348 Segment-specific regulation of the Drosophila AP-2 gene during leg and antennal development. [FBrf0213960] Chatterjee et al., 2011, Development 138(6): 1099--1109 The female-specific Doublesex isoform regulates pleiotropic transcription factors to pattern genital development in Drosophila. [FBrf0213054] Datta et al., 2011, Dev. Biol. 360(2): 391--402 A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity. [FBrf0216557] Datta et al., 2011, Evol. Dev. 13(1): 58--71 Differential selection within the Drosophila retinal determination network and evidence for functional divergence between paralog pairs. [FBrf0212714] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Galindo et al., 2011, Dev. Biol. 353(2): 396--410 Control of Distal-less expression in the Drosophila appendages by functional 3' enhancers. [FBrf0213529] Giorgianni and Mann, 2011, Dev. Cell 20(4): 455--468 Establishment of Medial Fates along the Proximodistal Axis of the Drosophila Leg through Direct Activation of dachshund by Distalless. [FBrf0213490] Hasegawa et al., 2011, Development 138(5): 983--993 Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. [FBrf0213020] Hwang and Rulifson, 2011, Development 138(14): 2883--2893 Serial specification of diverse neuroblast identities from a neurogenic placode by Notch and Egfr signaling. [FBrf0214015] Jepson et al., 2011, J. Biol. Chem. 286(10): 8325--8337 Engineered Alterations in RNA Editing Modulate Complex Behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. [FBrf0213236] Kawamori et al., 2011, Dev. Growth Differ. 53(5): 653--667 Fat / Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. [FBrf0213932] Olson et al., 2011, EMBO Rep. 12(10): 1047--1054 Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye. [FBrf0216277] Royo et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(34): 14186--14191 Transphyletic conservation of developmental regulatory state in animal evolution. [FBrf0214810] Wang et al., 2011, Dev. Biol. 350(2): 414--428 Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. [FBrf0212909] Zhang et al., 2011, PLoS ONE 6(7): e22278 Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...