A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\noc

General Information
SymbolDmel\nocSpeciesD. melanogaster
Nameno ocelliAnnotation symbolCG4491
Feature typeprotein_coding_geneFlyBase IDFBgn0005771
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map
Cytogenetic map35B2-35B2Sequence location2L:14,490,862..14,494,019 [+]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
The gene no ocelli is referred to in FlyBase by the symbol noc (CG4491, FBgn0005771). It has the cytological map location 35B2. Its sequence location is 2L:14490862..14494019. Its molecular function is described as: RNA polymerase II transcription factor activity; zinc ion binding. It is involved in the biological processes: regulation of transcription from RNA polymerase II promoter; open tracheal system development. 52 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult; embryonic/larval tracheal system; adult segment; adult mesothoracic segment; head capsule; embryonic dorsal branch; adult brain; adult external prothorax; embryonic ganglionic branch; postalar bristle. It has one annotated transcript and one annotated polypeptide.

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
l(2)35Ba
l(2)35Ba1 may escape in combination with deficiency for the locus; escapers are weak elbow in phenotype if deficiency includes el, but not if it does not. All alleles express weak elbow in combination with el1; heteroallelic escapers [i.e., l(2)35Ba4 in combination with other alleles] are weak elbow. Semilethal with In(2LR)Scorv1 and Scorv27; also show weak noc phenotype in combination with strong noc alleles.
noc: no ocelli
The genetic complexity of noc is indicated by phenotypic as well as molecular data (McGill et al., 1988). Mutants are characterized by partial or complete absence of ocelli and their associated bristles. Strong noc alleles lack all three ocelli and have fewer interocellar microchaetae; ocellar and interocellar bristles are absent; anterior postalar and notopleural bristles may not be present; postvertical bristles are crooked, an adventitious pair often occurring between a normal pair. Weak alleles may overlap wild type in phenotype, the flies having smaller ocelli and an aberrant pattern of interocellar microchaetae. Male and female homozygotes are viable and fertile. Penetrance and expressivity is stronger in males and in flies that emerge later. While a homozygous deletion of the entire noc region is lethal, distal or proximal regions can be homozygously deleted without causing lethality. Some noc alleles and deficiences are lethal with In(2L)Scorv1, whose 2L breakpoint lies within noc, while other alleles are viable with the Sco inversion.
Sco: Scutoid
Sco/+ flies exhibit the loss of 10-15 bristles, scutellars, notopleurals, upper humerals and anterior postalars being most frequently affected; removes both trichogen and tormogen cell derivatives. Homozygotes nearly lethal; rare homozygous or hemizygous escapers have only eight or so bristles per fly; eyes small and very rough. Escapers short lived and sterile. RK1A.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
35B2-35B2  
Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
35A4-35A4
(determined by in situ hybridisation)  
35B1-35B2
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
In direction of increasing cytology: CG15283- noc+ tRNA:P:35Bd+
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\noc for information on other features
detailed view FBtr0080643 FBpp0080215 FBti0010908 FBti0040238 FBti0069596 FBti0010757 FBti0054006 FBti0026049 FBti0068890 FBti0023349 FBti0036034 FBti0034352 FBti0029431 FBti0059071 FBti0029361 FBti0056435 FBti0024884
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0080643
  2856
  537
Additional Transcript Data & Comments
Reported size (kB)
~3 (northern blot)
Comments
The two noc transcripts differ only the length of the 3\\' untranslated region (one is 236 bases longer) and have at least one intron of ~250 bases.
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
noc-PA  
FBpp0080215  
54.0  
537  
9.13  
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    aberration junction
    evidence=experimental
    linked_to=SstI-SstI_rfrag
    comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator
    aberration junction
    In(2LR)noc[4].bk1
    2L:14,496,466..14,501,864
    evidence=experimental
    linked_to=SstI-HindIII_rfrag
    comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator
    aberration junction
    evidence=experimental
    linked_to=SalI-SalI_rfrag
    comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator
    aberration junction
    evidence=experimental
    linked_to=HindIII-SalI_rfrag
    comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     embryonic stage | stage 5
     embryonic stage | stage 8-12
     labral segment
     embryonic stage | stage 8-12
     stomodeum
     embryonic stage | stage 10-12
     tracheal placode | surrounding
     embryonic stage-adult stage
     embryonic stage | stage 5
     embryonic stage | stage 5-6
     ectoderm | stripes
     embryonic stage | stage 8
     ventral neurectoderm
     embryonic stage | stage 8-12
     procephalic segment
     embryonic stage | stage 9
     neurectoderm | stripes
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0080643
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        FlyExpress - Embryonic expression images (BDGP data)
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        Other Phenotypes
        Allele
        Phenotype manifest in
        Allele
        hide Classical Alleles ( 49 )
        For All Classical Alleles Show

        Allele of nocClassMutagenStocksKnown lesion
        noc140 --
        noc150 --
        noc180 --
        noc190 --
        noc210 --
        noc220 --
        noc230 --
        noc20 Yes
        noc35Ba-11 --
        noc35Ba-21 --
        noc35Ba-30 --
        noc35Ba-40 --
        noc41 Yes
        noc60 --
        noc70 Yes
        nocA178
          0 Yes
          nocA446
            0 Yes
            nocEP20001 --
            nocEP21731 Yes
            nocGAL4
              0 Yes
              nocGT81 --
              nocSZ50 --
              nocSco-rv110 --
              nocSco-rv120 --
              nocSco-rv130 --
              nocSco-rv150 --
              nocSco-rv170 --
              nocSco-rv10 --
              nocSco-rv210 --
              nocSco-rv230 --
              nocSco-rv240 --
              nocSco-rv260 --
              nocSco-rv270 Yes
              nocSco-rv20 --
              nocSco-rv50 --
              nocSco-rv80 --
              nocSco-rv90 --
              nocSco88 Yes
              nocTE35B-50
                0 Yes
                nocTE35B-54L
                  0 Yes
                  nocTE35Bamorph4 Yes
                  nocd640 Yes
                  nocel-1
                    0 --
                    nocnBR1060 --
                    nocnBR1190 --
                    nocnBR1260 --
                    nocnNxF1
                      0 --
                      nocnNxF2
                        0 --
                        nocosp144
                          0 Yes
                          hide Alleles Carried on Transgenic Constructs ( 3 )
                          For All Alleles Carried on Transgenic Constructs Show

                          Allele of nocClassMutagenStocksKnown lesion
                          nocGD14970 Yes
                          nocScer\UAS.cDa0 Yes
                          nocdsRNA.cTa0 Yes
                          hide Aneuploid Aberrations
                          Useful deficiency
                          Useful duplication
                          Disrupted in