The gene no ocelli is referred to in FlyBase by the symbol Dmel\noc (CG4491, FBgn0005771). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; wing disc development; eye-antennal disc development; cell proliferation; ocellus development; negative regulation of gene expression; brain development; leg disc development; open tracheal system development. 41 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult; late extended germ band embryo; tracheal branch primordium; sense organ; region of integument; non-connected developing system; dorsal branch primordium; postalar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, adult Malpighian tubules, adult heart, larval salivary gland, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625960_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of noc. Gene sequence location is 2L:14490862..14494019.
User Contributed Data
Phenotypic Description from the Red Book (Lindsley
& Zimm 1992)
Gene/Allele symbols may differ
from current usage
l(2)35Ba
l(2)35Ba1 may escape in combination with deficiency
for the locus; escapers are weak elbow in phenotype if deficiency includes el, but not if it does not. All alleles
express weak elbow in combination with el1; heteroallelic
escapers [i.e., l(2)35Ba4 in combination with other alleles]
are weak elbow. Semilethal with In(2LR)Scorv1 and Scorv27;
also show weak noc phenotype in combination with strong noc
alleles.
noc: no ocelli
The genetic complexity of noc is indicated by
phenotypic as well as molecular data (McGill et al., 1988).
Mutants are characterized by partial or complete absence of
ocelli and their associated bristles. Strong noc alleles lack
all three ocelli and have fewer interocellar microchaetae;
ocellar and interocellar bristles are absent; anterior postalar and notopleural bristles may not be present; postvertical bristles are crooked, an adventitious pair often occurring
between a normal pair. Weak alleles may overlap wild type in
phenotype, the flies having smaller ocelli and an aberrant
pattern of interocellar microchaetae. Male and female homozygotes are viable and fertile. Penetrance and expressivity is
stronger in males and in flies that emerge later. While a
homozygous deletion of the entire noc region is lethal, distal
or proximal regions can be homozygously deleted without causing lethality. Some noc alleles and deficiences are lethal
with In(2L)Scorv1, whose 2L breakpoint lies within noc, while
other alleles are viable with the Sco inversion.
Sco: Scutoid
Sco/+ flies exhibit the loss of 10-15 bristles, scutellars, notopleurals, upper humerals and anterior postalars
being most frequently affected; removes both trichogen and
tormogen cell derivatives. Homozygotes nearly lethal; rare
homozygous or hemizygous escapers have only eight or so bristles per fly; eyes small and very rough. Escapers short lived
and sterile. RK1A.
Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release.
It currently only tracks new links between this FlyBase report and other
FlyBase data classes (e.g. genes, references, stocks) or controlled
vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your
feed reader.
noc transcripts are detected in all stages on northern blots with maximal levels occuring in embryonic and pupal stages as well as in adult heads. The two transcripts are present in nearly equal amounts and appear to be coordinately regulated. Transcripts are first detected by in situ hybridization in cellular blastoderm embryos in a rapidly evolving pattern. The initial hybridization at 95-100% egg length retracts to a stripe at 90-95% egg length. This is followed by an additional 2 stripes just posterior to the initial stripe and a stripe near the posterior terminus. 6 more stripes appear along the trunk giving a total of 10. During gastrulation, the 2nd and 3rd anterior-most stripes border the cephalic furrow. Striped expression disappears after gastrulation. By stage 8, expression is seen in the procephalic lobe and along the ventral ectoderm from 50-90% egg length, spanning the cephalic furrow. 12 stripes of expression are seen in the neuroectoderm in stage 9. In stages 10-12, ectodermal expression abd expression around tracheal placodes decreases. Cephlaic expression occurs as two groups of dorsal ectodermal cells in the procephalic lobe as well as the labral segment and stomodeum. After stage 13, no clear pattern is seen and expression is thought to be ubiquitous.
Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, adult Malpighian tubules, adult heart, larval salivary gland, adult spermathecae, adult carcass.
[download data (TSV)]
Guide to FlyAtlas expression level colors
No expression (0 - 9.999)
Low expression (10 - 99.999)
Moderate expression (100 - 499.999)
High level expression (500 - 999.999)
Very high expression (>999.999)
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
1330.825
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
930.1
Larval Salivary Gland
346.9
Larval Trachea
1288.225
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
837.5
Adult Thoracic-Abdominal Ganglion
1018.9
Adult Crop
824.4
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
1293.3
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(1330.825)
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
(573.7)
Larval Fat Body
(930.1)
Larval Salivary Gland
346.9
Larval Trachea
(1288.225)
Larval Carcass
(592.55)
Adult Head
(621.4)
Adult Eye
446.775
Adult Brain
(837.5)
Adult Thoracic-Abdominal Ganglion
(1018.9)
Adult Crop
(824.4)
Adult Midgut
302.6
Adult Hindgut
(813.4)
Adult Malpighian Tubules
256.1
Adult Fat Body
(590.8)
Adult Salivary Gland
(1293.3)
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
(1330.825)
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
930.1
Larval Salivary Gland
346.9
Larval Trachea
(1288.225)
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
837.5
Adult Thoracic-Abdominal Ganglion
1018.9
Adult Crop
824.4
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
(1293.3)
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
1330.825
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
930.1
Larval Salivary Gland
346.9
Larval Trachea
1288.225
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
837.5
Adult Thoracic-Abdominal Ganglion
1018.9
Adult Crop
824.4
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
1293.3
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
1330.825
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
930.1
Larval Salivary Gland
346.9
Larval Trachea
1288.225
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
837.5
Adult Thoracic-Abdominal Ganglion
1018.9
Adult Crop
824.4
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
1293.3
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(1330.825)
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
(930.1)
Larval Salivary Gland
346.9
Larval Trachea
(1288.225)
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
(837.5)
Adult Thoracic-Abdominal Ganglion
(1018.9)
Adult Crop
(824.4)
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
(1293.3)
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
1330.825
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
930.1
Larval Salivary Gland
346.9
Larval Trachea
1288.225
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
837.5
Adult Thoracic-Abdominal Ganglion
1018.9
Adult Crop
824.4
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
1293.3
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
1330.825
Larval Midgut
339
Larval Hindgut
533.4
Larval Malpighian Tubules
573.7
Larval Fat Body
930.1
Larval Salivary Gland
346.9
Larval Trachea
1288.225
Larval Carcass
592.55
Adult Head
621.4
Adult Eye
446.775
Adult Brain
837.5
Adult Thoracic-Abdominal Ganglion
1018.9
Adult Crop
824.4
Adult Midgut
302.6
Adult Hindgut
813.4
Adult Malpighian Tubules
256.1
Adult Fat Body
590.8
Adult Salivary Gland
1293.3
Adult Heart
252.7
Adult VirginFemale Spermatheca
471.6
Adult InseminatedFemale Spermatheca
482.5
Adult Ovary
44.5
Adult Testis
31.3
Adult Male Accessory Gland
25.6
Adult Carcass
414.7
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages.
[download data (TSV)]
Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 150 )
Please Note
This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see GBrowse for alignment of the cDNAs and ESTs
to the gene model.
The "Sco" (Scutoid) mutant allele was previously listed as an allele of noc in FlyBase, as genetic analysis showed that a high dose of the wild-type noc gene suppresses the expressivity of the Sco phenotype, suggesting that Sco was an antimorphic allele of noc (FBrf0038047). However, FBrf0111871 shows that Sco is in fact an antimorphic allele of sna, and the mutant phenotype is caused by ectopic expression of sna in the eye-antennal and wing imaginal discs. The Sco allele is therefore now listed as an allele of sna in FlyBase. FBrf0111871 suggests that the reason that noc in trans affects the expressivity of Sco may be due to transvection effects, as they show that mutations in z, a mediator of transvection, also affect the Sco mutant phenotype.