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Gene Dmel\noc

General Information
Symbol	Dmel\noc	Species	D. melanogaster
Name	no ocelli	Annotation symbol	CG4491
Feature type	protein_coding_gene	FlyBase ID	FBgn0005771
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	l(2)35Ba, nocA, l(2)br22, br22, BG:DS04641.1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35B2-35B2	Sequence location	2L:14,490,859..14,494,019 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene no ocelli is referred to in FlyBase by the symbol Dmel\noc (CG4491, FBgn0005771). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; wing disc development; eye-antennal disc development; cell proliferation; ocellus development; negative regulation of gene expression; brain development; leg disc development; open tracheal system development. 41 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; adult; late extended germ band embryo; tracheal branch primordium; sense organ; region of integument; non-connected developing system; dorsal branch primordium; postalar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, adult Malpighian tubules, adult heart, larval salivary gland, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625960_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of noc. Gene sequence location is 2L:14490862..14494019.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)35Ba l(2)35Ba1 may escape in combination with deficiency for the locus; escapers are weak elbow in phenotype if deficiency includes el, but not if it does not. All alleles express weak elbow in combination with el1; heteroallelic escapers [i.e., l(2)35Ba4 in combination with other alleles] are weak elbow. Semilethal with In(2LR)Scorv1 and Scorv27; also show weak noc phenotype in combination with strong noc alleles. noc: no ocelli The genetic complexity of noc is indicated by phenotypic as well as molecular data (McGill et al., 1988). Mutants are characterized by partial or complete absence of ocelli and their associated bristles. Strong noc alleles lack all three ocelli and have fewer interocellar microchaetae; ocellar and interocellar bristles are absent; anterior postalar and notopleural bristles may not be present; postvertical bristles are crooked, an adventitious pair often occurring between a normal pair. Weak alleles may overlap wild type in phenotype, the flies having smaller ocelli and an aberrant pattern of interocellar microchaetae. Male and female homozygotes are viable and fertile. Penetrance and expressivity is stronger in males and in flies that emerge later. While a homozygous deletion of the entire noc region is lethal, distal or proximal regions can be homozygously deleted without causing lethality. Some noc alleles and deficiences are lethal with In(2L)Scorv1, whose 2L breakpoint lies within noc, while other alleles are viable with the Sco inversion. Sco: Scutoid Sco/+ flies exhibit the loss of 10-15 bristles, scutellars, notopleurals, upper humerals and anterior postalars being most frequently affected; removes both trichogen and tormogen cell derivatives. Homozygotes nearly lethal; rare homozygous or hemizygous escapers have only eight or so bristles per fly; eyes small and very rough. Escapers short lived and sterile. RK1A.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides noc-PB Transcripts noc-RB
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35B2-35B2   Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35A4-35A4   (determined by in situ hybridisation)   (McGill et al., 1988) 35B1-35B2   (determined by in situ hybridisation)   (Chia et al., 1985)
Experimentally Determined Recombination Data
Location	2- (Krivshenko, 1959) 2-51.0 (Tomkiel et al., 1995)
Left of (cM)
Right of (cM)	abo J (Tomkiel et al., 1995)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\noc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) noc-RA FBtr0080643  NM_057569   2859   537 noc-RB FBtr0342913     2673   537
Additional Transcript Data & Comments
Reported size (kB)	~3 (northern blot) (Cheah et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein noc-PA   FBpp0080215   54.0   537   9.13     NP_476917   AAF53399 noc-PB   FBpp0309705   54.0   537   9.13
Additional Polypeptide Data & Comments
Reported size (kDa)	537 (aa) (Cheah et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696574   AA949253   AA949254   AE014134 AAF53399   AC092228   AE003410 AAF44877   AI257598   AI258572   AI259511   AI260716   AI456142   AQ073367   AQ074104   AW942795   AY070550 AAL48021   BI162269   BI162270   BI170157   BI172667   BI173140   BI214300   BI227568   BI231701   BI238185   BI358605   BI363528   BI364884   BI366236   BI484693   BI485479   BI581805   BP555890   CK660728   CO176866   CO189651   CO266165   CO285932   CO292386   CO293641   CO297854   CO298510   CO298987   CO302102   CO303447   CO303650   CO304254   CO306117   CO306584   CO309730   CO312041   CO314849   CO315271   CO316906   CO319733   CO321588   CO322620   CO323905   CO324833   CO328863   CO332224   EC058410   EC059716   EC063381   EC066559   EC068423   EC072306   EC077349   EC079953   EC080791   EC085907   EC086503   EC088074   EC089473   EC089926   EC089930   EC194567   EC203084   EC203147   EC204561   EC204711   EC211388   EC211496   EC212653   EC213791   EC214273   EC221134   EC226060   EC226705   EC228172   EC229028   EC249014   GH749745   GH752627   GH752859   GH758422   GH760627   GH774217   GH779883   GH781042   GH783381   GH791720   GH795792   GH797015   GH798042   GH801868   GH801938   GH803300   GH808499   GH809097   GH810748   GH811726   GH813499   GH814428   GH815127   GH816964   GH819469   GH820500   GH821863   GH822188   GH823067   GH824686   GH824779   GH826492   GH827553   GH831082   GH832586   GH834804   GH837825   GH840909   GH843989   GH847663   GH849604   GH852693   GH859914   GH860224   GH861423   GH861575   GH866672   GH868794   GH868945   GH869311   GH869771   GH873145   GH873759   GH877705   GH877880   GH878132   GH878776   GH883359   GH886218   GH893370   GH893810   GH896077   GH905584   GH906472   GH907569   GH908273   GH910558   GH912962   GH917408   GH930117   GH931159   L14009 AAA16473
UniProtKB/Swiss-Prot	Q24423
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | anterior & terminal expression pattern   (Dorfman et al., 2002) organism | posterior & terminal expression pattern   (Dorfman et al., 2002) embryonic stage 4 -- 6   anlage in statu nascendi   (Fisher et al., 2012) central brain anlage in statu nascendi   (Fisher et al., 2012) ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi foregut anlage in statu nascendi   (Fisher et al., 2012) hindgut anlage in statu nascendi   (Fisher et al., 2012) posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi antennal anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi dorsal head epidermis anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi visual anlage in statu nascendi   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage in statu nascendi embryonic stage 5   organism | 90-100% egg length   (Cheah et al., 1994) Comment:90-95% egg length embryonic stage 5 -- 6   ectoderm | striped   (Cheah et al., 1994, Dorfman et al., 2002) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage foregut anlage   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 8   ventral nerve cord primordium | 50-90% egg length   (Cheah et al., 1994) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium foregut primordium   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 10 -- 12   tracheal primordium | surrounding   (Cheah et al., 1994) embryonic stage 11   tracheal pit   (Dorfman et al., 2002) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) labial sensory complex primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) posterior spiracle primordium   (Fisher et al., 2012) Comment:reported as posterior spiracle specific anlage tracheal primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic optic lobe   (Fisher et al., 2012) embryonic/larval fat body   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval midgut interstitial cell   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) embryonic stage 13 -- 17   organism | ubiquitous   (Dorfman et al., 2002) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Cheah et al., 1994) embryonic stage 8 -- 12   labral segment   (Cheah et al., 1994) stomodeum   (Cheah et al., 1994) procephalic segment   (Cheah et al., 1994) embryonic stage 9   ventral neurectoderm | striped   (Cheah et al., 1994)
Additional Descriptive Data
	noc transcripts are detected in all stages on northern blots with maximal levels occuring in embryonic and pupal stages as well as in adult heads. The two transcripts are present in nearly equal amounts and appear to be coordinately regulated. Transcripts are first detected by in situ hybridization in cellular blastoderm embryos in a rapidly evolving pattern. The initial hybridization at 95-100% egg length retracts to a stripe at 90-95% egg length. This is followed by an additional 2 stripes just posterior to the initial stripe and a stripe near the posterior terminus. 6 more stripes appear along the trunk giving a total of 10. During gastrulation, the 2nd and 3rd anterior-most stripes border the cephalic furrow. Striped expression disappears after gastrulation. By stage 8, expression is seen in the procephalic lobe and along the ventral ectoderm from 50-90% egg length, spanning the cephalic furrow. 12 stripes of expression are seen in the neuroectoderm in stage 9. In stages 10-12, ectodermal expression abd expression around tracheal placodes decreases. Cephlaic expression occurs as two groups of dorsal ectodermal cells in the procephalic lobe as well as the labral segment and stomodeum. After stage 13, no clear pattern is seen and expression is thought to be ubiquitous. (Cheah et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, larval Malpighian tubules, larval/adult fat body, adult salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult midgut, adult Malpighian tubules, adult heart, larval salivary gland, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1330.825 Larval Midgut    339 Larval Hindgut    533.4 Larval Malpighian Tubules    573.7 Larval Fat Body    930.1 Larval Salivary Gland    346.9 Larval Trachea    1288.225 Larval Carcass    592.55 Adult Head    621.4 Adult Eye    446.775 Adult Brain    837.5 Adult Thoracic-Abdominal Ganglion    1018.9 Adult Crop    824.4 Adult Midgut    302.6 Adult Hindgut    813.4 Adult Malpighian Tubules    256.1 Adult Fat Body    590.8 Adult Salivary Gland    1293.3 Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1330.825) Larval Midgut    339 Larval Hindgut  533.4 Larval Malpighian Tubules  (573.7) Larval Fat Body  (930.1) Larval Salivary Gland    346.9 Larval Trachea  (1288.225) Larval Carcass  (592.55) Adult Head  (621.4) Adult Eye    446.775 Adult Brain  (837.5) Adult Thoracic-Abdominal Ganglion  (1018.9) Adult Crop  (824.4) Adult Midgut    302.6 Adult Hindgut  (813.4) Adult Malpighian Tubules    256.1 Adult Fat Body  (590.8) Adult Salivary Gland  (1293.3) Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1330.825) Larval Midgut    339 Larval Hindgut    533.4 Larval Malpighian Tubules    573.7 Larval Fat Body    930.1 Larval Salivary Gland    346.9 Larval Trachea  (1288.225) Larval Carcass    592.55 Adult Head    621.4 Adult Eye    446.775 Adult Brain    837.5 Adult Thoracic-Abdominal Ganglion  1018.9 Adult Crop    824.4 Adult Midgut    302.6 Adult Hindgut    813.4 Adult Malpighian Tubules    256.1 Adult Fat Body    590.8 Adult Salivary Gland  (1293.3) Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1330.825 Larval Midgut    339 Larval Hindgut    533.4 Larval Malpighian Tubules    573.7 Larval Fat Body    930.1 Larval Salivary Gland    346.9 Larval Trachea    1288.225 Larval Carcass    592.55 Adult Head    621.4 Adult Eye    446.775 Adult Brain    837.5 Adult Thoracic-Abdominal Ganglion    1018.9 Adult Crop    824.4 Adult Midgut    302.6 Adult Hindgut    813.4 Adult Malpighian Tubules    256.1 Adult Fat Body    590.8 Adult Salivary Gland    1293.3 Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1330.825 Larval Midgut    339 Larval Hindgut    533.4 Larval Malpighian Tubules    573.7 Larval Fat Body    930.1 Larval Salivary Gland    346.9 Larval Trachea    1288.225 Larval Carcass    592.55 Adult Head    621.4 Adult Eye    446.775 Adult Brain    837.5 Adult Thoracic-Abdominal Ganglion    1018.9 Adult Crop    824.4 Adult Midgut    302.6 Adult Hindgut    813.4 Adult Malpighian Tubules    256.1 Adult Fat Body    590.8 Adult Salivary Gland    1293.3 Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1330.825) Larval Midgut    339 Larval Hindgut  533.4 Larval Malpighian Tubules  573.7 Larval Fat Body  (930.1) Larval Salivary Gland    346.9 Larval Trachea  (1288.225) Larval Carcass  592.55 Adult Head  621.4 Adult Eye    446.775 Adult Brain  (837.5) Adult Thoracic-Abdominal Ganglion  (1018.9) Adult Crop  (824.4) Adult Midgut    302.6 Adult Hindgut  813.4 Adult Malpighian Tubules    256.1 Adult Fat Body  590.8 Adult Salivary Gland  (1293.3) Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1330.825 Larval Midgut    339 Larval Hindgut    533.4 Larval Malpighian Tubules    573.7 Larval Fat Body    930.1 Larval Salivary Gland    346.9 Larval Trachea  1288.225 Larval Carcass    592.55 Adult Head    621.4 Adult Eye    446.775 Adult Brain    837.5 Adult Thoracic-Abdominal Ganglion  1018.9 Adult Crop    824.4 Adult Midgut    302.6 Adult Hindgut    813.4 Adult Malpighian Tubules    256.1 Adult Fat Body    590.8 Adult Salivary Gland  1293.3 Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1330.825 Larval Midgut    339 Larval Hindgut    533.4 Larval Malpighian Tubules    573.7 Larval Fat Body    930.1 Larval Salivary Gland    346.9 Larval Trachea    1288.225 Larval Carcass    592.55 Adult Head    621.4 Adult Eye    446.775 Adult Brain    837.5 Adult Thoracic-Abdominal Ganglion    1018.9 Adult Crop    824.4 Adult Midgut    302.6 Adult Hindgut    813.4 Adult Malpighian Tubules    256.1 Adult Fat Body    590.8 Adult Salivary Gland    1293.3 Adult Heart    252.7 Adult VirginFemale Spermatheca    471.6 Adult InseminatedFemale Spermatheca    482.5 Adult Ovary    44.5 Adult Testis    31.3 Adult Male Accessory Gland    25.6 Adult Carcass    414.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    621.4   NA  Eye    446.775   NA  Brain    837.5   1330.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1018.9   NA  Crop    824.4   339  Midgut    302.6   533.4  Hindgut    813.4   573.7  Malpighian Tubules    256.1   930.1  Fat Body    590.8   346.9  Salivary Gland    1293.3   NA  Heart    252.7   1288.225  Trachea    NA   NA  VirginFemale Spermatheca    471.6   NA  InseminatedFemale Spermatheca    482.5   NA  Ovary    44.5   NA  Testis    31.3   NA  Male Accessory Gland    25.6   592.55  Carcass    414.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    58 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering    38 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (58) central nervous system, pupae P8  (27) head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering  (38) carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    58 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering    38 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    58 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering    38 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    58 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering    38 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (48) central nervous system, larvae L3  (58) central nervous system, pupae P8  27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering  (38) carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    58 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering    38 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    48 central nervous system, larvae L3    58 central nervous system, pupae P8    27 head, virgin 1-day female    15 head, virgin 4-day female    16 head, virgin 20-day female    16 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    16 head, mated 1-day male    21 head, mated 4-day male    17 head, mated 20-day male    18 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    10 digestive system, 4-day adult    12 digestive system, 20-day adult    12 fat body, larvae L3 wandering    10 fat body, white prepupae    16 fat body, pupae P8    22 carcass, larvae L3 wandering    38 carcass, 1-day adult    12 carcass, 4-day adult    12 carcass, 20-day adult    16 ovary, virgin 4-day female    1 ovary, mated 4-day female    1 testis, mated 4-day male    1 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    42 embryo 04-06hr    101 embryo 06-08hr    100 embryo 08-10hr    93 embryo 10-12hr    93 embryo 12-14hr    57 embryo 14-16hr    42 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    28 embryo 22-24hr    27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    40 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr  (42) embryo 04-06hr  (101) embryo 06-08hr  (100) embryo 08-10hr  (93) embryo 10-12hr  (93) embryo 12-14hr  (57) embryo 14-16hr  (42) embryo 16-18hr  (36) embryo 18-20hr  (34) embryo 20-22hr  (28) embryo 22-24hr  (27) larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  26 white prepupae new    25 white prepupae 12hr  (40) white prepupae 24hr  (38) pupae 2d postWPP  (27) pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    42 embryo 04-06hr  101 embryo 06-08hr    100 embryo 08-10hr    93 embryo 10-12hr    93 embryo 12-14hr    57 embryo 14-16hr    42 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    28 embryo 22-24hr    27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    40 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    42 embryo 04-06hr    101 embryo 06-08hr    100 embryo 08-10hr    93 embryo 10-12hr    93 embryo 12-14hr    57 embryo 14-16hr    42 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    28 embryo 22-24hr    27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    40 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    42 embryo 04-06hr    101 embryo 06-08hr    100 embryo 08-10hr    93 embryo 10-12hr    93 embryo 12-14hr    57 embryo 14-16hr    42 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    28 embryo 22-24hr    27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    40 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr  (42) embryo 04-06hr  (101) embryo 06-08hr  (100) embryo 08-10hr  (93) embryo 10-12hr  (93) embryo 12-14hr  (57) embryo 14-16hr  (42) embryo 16-18hr  (36) embryo 18-20hr  (34) embryo 20-22hr  28 embryo 22-24hr  27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  26 white prepupae new    25 white prepupae 12hr  (40) white prepupae 24hr  (38) pupae 2d postWPP  27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    42 embryo 04-06hr  101 embryo 06-08hr    100 embryo 08-10hr    93 embryo 10-12hr    93 embryo 12-14hr    57 embryo 14-16hr    42 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    28 embryo 22-24hr    27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    40 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    42 embryo 04-06hr    101 embryo 06-08hr    100 embryo 08-10hr    93 embryo 10-12hr    93 embryo 12-14hr    57 embryo 14-16hr    42 embryo 16-18hr    36 embryo 18-20hr    34 embryo 20-22hr    28 embryo 22-24hr    27 larva L1    20 larva L2    12 larva L3 12hr old    11 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    40 white prepupae 24hr    38 pupae 2d postWPP    27 pupae 3d postWPP    15 pupae 4d postWPP    10 adult male 01day    10 adult male 05day    10 adult male 30day    8 adult female 01day    8 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    54 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1    34 wing disc CME-W2    0 wing disc ML-DmD8    78 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    79 ovary OSC    61 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4  (54) embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1  (34) wing disc CME-W2    0 wing disc ML-DmD8  (78) wing disc ML-DmD9    1 wing disc ML-DmD16-c3  (39) wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS  (79) ovary OSC  (61) ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    54 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1    34 wing disc CME-W2    0 wing disc ML-DmD8    78 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    79 ovary OSC    61 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    54 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1    34 wing disc CME-W2    0 wing disc ML-DmD8    78 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    79 ovary OSC    61 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    54 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1    34 wing disc CME-W2    0 wing disc ML-DmD8    78 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    79 ovary OSC    61 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4  (54) embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1  (34) wing disc CME-W2    0 wing disc ML-DmD8  (78) wing disc ML-DmD9    1 wing disc ML-DmD16-c3  (39) wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS  (79) ovary OSC  (61) ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    54 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1    34 wing disc CME-W2    0 wing disc ML-DmD8    78 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    79 ovary OSC    61 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    54 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    6 leg disc CME L1    34 wing disc CME-W2    0 wing disc ML-DmD8    78 wing disc ML-DmD9    1 wing disc ML-DmD16-c3    39 wing disc ML-DmD21    0 wing disc ML-DmD32    11 haltere disc ML-DmD17-c3    2 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    20 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    79 ovary OSC    61 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    9 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    8 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    11 Caffeine 1.5 mg/ml 4 hrs, larvae L3    12 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    9 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD28078 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005771 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4491-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for noc Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | larval stage | recessive noc35Ba-1 noc35Ba-2 noc35Ba-3 noc35Ba-4 lethal | recessive noc35Ba-1 noc35Ba-4 nocSZ5 viable nocTE35B viable (with Df(2L)fn7) noc14 noc15 noc18 noc19 Other Phenotypes Allele behavior defective | recessive nocBG01916 visible | recessive noc2 noc4 noc7 nocTE35B Phenotype manifest in Allele anterior postalar bristle noc2 nocTE35B dorsal branch primordium nocd64 ganglionic branch primordium nocd64 head bristle noc4 nocTE35B lateral ocellus noc2 noc7 lateral trunk anterior branch nocd64 macrochaeta nocGT8 medial ocellus noc7 microchaeta noc2 nocTE35B ocellar bristle noc2 noc7 nocTE35B ocellus noc2 noc4 nocTE35B postvertical bristle noc2 noc7 supraesophageal ganglion noc35Ba-1 noc35Ba-2 noc35Ba-3
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of noc Class Mutagen Stocks Known lesion nocTE35B amorphic allele - genetic evidence spontaneous 5 Yes noc35Ba-1 ethyl methanesulfonate 1 -- noc35Ba-2 ethyl methanesulfonate 1 -- noc4 gamma ray 1 Yes noc14 gamma ray 0 -- noc15 gamma ray 0 -- noc18 ethyl methanesulfonate 0 -- noc19 ethyl methanesulfonate 0 -- noc21 gamma ray 0 -- noc22 ethyl methanesulfonate 0 -- noc23 ethyl methanesulfonate 0 -- noc2 ethyl methanesulfonate 0 Yes noc35Ba-3 ethyl methanesulfonate 0 -- noc35Ba-4 ethyl methanesulfonate 0 -- noc6 gamma ray 0 -- noc7 gamma ray 0 Yes nocA178 0 Yes nocA446 0 Yes nocBG01916 0 -- nocd64 Delta2-3 0 Yes nocel-1 0 -- nocEP2000 P-element activity 0 -- nocEP2173 P-element activity 0 Yes nocGAL4 0 Yes nocGT8 gamma ray X ray 0 -- nocnBR106 3H 0 -- nocnBR119 3H 0 -- nocnBR126 3H 0 -- nocnNxF1 0 -- nocnNxF2 0 -- nocosp144 0 Yes nocSco-like transposable element activity 0 Yes nocSZ5 spontaneous 0 -- nocTE35B-50 0 Yes nocTE35B-54L 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of noc Class Mutagen Stocks Known lesion nocJF02534 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nocKK109977 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes nocdsRNA.cTa in vitro construct - RNAi 0 Yes nocGD1497 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes nocNIG.4491R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes nocScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)64j (O'Donnell et al., 1977, Woodruff and Ashburner, 1979) Df(2L)A47 (Ashburner et al., 1982, Gubb et al., 1990, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996) Df(2L)A178 (Ashburner et al., 1982, Ashburner et al., 1982, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)A215 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A217 (Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996) Df(2L)A245 (Ashburner et al., 1982, Davis et al., 1990, Cheah et al., 1994, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996) Df(2L)A246 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A260 (Ashburner et al., 1982, Davis et al., 1990, McNabb et al., 1996, Roote et al., 1996) Df(2L)A263 (Ashburner et al., 1982) Df(2L)A266 (Ashburner et al., 1982, Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996) Df(2L)A267 (Ashburner et al., 1982, Ashburner et al., 1982) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A377 (Ashburner et al., 1982) Df(2L)A379 (Ashburner et al., 1982, Ashburner et al., 1982, McNabb et al., 1996) Df(2L)A400 (Ashburner et al., 1982, Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)A445 (Ashburner et al., 1982, McNabb et al., 1996) Df(2L)Adh-nBR41 (Fossett et al., 1990) Df(2L)Adh-nBR55 (Fossett et al., 1990) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994, Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR106 (Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994, Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR119 (Roote, 1996.1.11) Df(2L)Adh-nBR120 (Fossett et al., 1994) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Roote, 1996.1.11) Df(2L)Adh-nBR129 (Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)ARR1 (Davis et al., 1990, Roote et al., 1996) Df(2L)b81a1 (Ashburner et al., 1982, Roote et al., 1996) Df(2L)b84a1 (McNabb et al., 1996) Df(2L)b84a4 (Roote, 2000.7.3, McNabb et al., 1996, Roote et al., 1996) Df(2L)b84a5 (Roote et al., 1996) Df(2L)b84a8 (Roote, 2000.7.3, McNabb et al., 1996, Roote et al., 1996, Roote, 1996.8) Df(2L)b88c25 (Alexandrova et al., 1996) Df(2L)BSC862 (Cook and Cook, 2010.2.17) Df(2L)do1 (Ashburner et al., 1981) Df(2L)ED3 (Roote, 2002.2.6, Ryder et al., 2004, Ryder and Roote, 2004.11.10) Df(2L)el14 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)el16 (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)el28 (Davis et al., 1990, Davis et al., 1997) Df(2L)el77 (Woodruff and Ashburner, 1979, McNabb et al., 1996) Df(2L)el80f1 (Ashburner et al., 1983) Df(2L)Exel8033 (Ryder, 2004.4.26) Df(2L)fn1 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) Df(2L)fn2 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984, McNabb et al., 1996, Roote et al., 1996, Davis et al., 1997) Df(2L)fn3 (O'Donnell et al., 1977, Ashburner et al., 1982, Davis et al., 1990, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)fn5 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn7 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982, McNabb et al., 1996) Df(2L)fn12 (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Ashburner et al., 1982) Df(2L)fn15 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn26 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn27 (O'Donnell et al., 1977, Ashburner et al., 1982, Ashburner et al., 1982) Df(2L)fn30 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn31 (O'Donnell et al., 1977, Ashburner et al., 1982) Df(2L)fn36 (O'Donnell et al., 1977, Ashburner et al., 1982, McNabb et al., 1996) Df(2L)fn52 (McNabb et al., 1996) Df(2L)GT4 (Gubb et al., 1990, McNabb et al., 1996, Roote et al., 1996) Df(2L)GT5 (Gubb et al., 1990, Roote, 1996.1.11, Roote, 1996.8) Df(2L)n78l3 (Ashburner et al., 1982, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)nNxF1 (Chia et al., 1985) Df(2L)nNxF2 (Chia et al., 1985) Df(2L)noc10 (McNabb et al., 1996) Df(2L)noc13 (McNabb et al., 1996) Df(2L)noc20 (McNabb et al., 1996) Df(2L)osp144 (Ashburner et al., 1982, McNabb et al., 1996, Roote, 1996.8) Df(2L)osp-204   Df(2L)PA4 (Ashburner et al., 1983) Df(2L)Sco7 (Ashburner et al., 1983) Df(2L)Scorv4 (Ashburner et al., 1983, Ashburner et al., 1990) Df(2L)Scorv10 (Ashburner et al., 1983, Grau et al., 1984) Df(2L)Scorv14 (Ashraf et al., 1999, Ashburner et al., 1983) Df(2L)Scorv16 (Ashburner et al., 1983, Grau et al., 1984) Df(2L)Scorv18 (Ashraf et al., 1999, Ashburner et al., 1983) Df(2L)Scorv19 (Ashburner et al., 1983, Grau et al., 1984) Df(2L)Scorv23 (Ashburner et al., 1983, Grau et al., 1984) Df(2L)Scorv25 (Ashburner et al., 1983, Grau et al., 1984) Df(2L)TE35B-1 (Gubb et al., 1985, Davis et al., 1990, Davis et al., 1997) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985, Davis et al., 1990, Davis et al., 1997) Df(2L)TE35B-7 (Gubb et al., 1985, Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)TE35B-8 (Gubb et al., 1985, McNabb et al., 1996, Roote et al., 1996) Df(2L)TE35B-9 (Gubb et al., 1985, McNabb et al., 1996) Df(2L)TE35B-10 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35B-11 (McNabb et al., 1996, Roote et al., 1996) Df(2L)TE35B-12 (Gubb et al., 1985, Roote et al., 1996, Roote, 1996.8, Davis et al., 1997) Df(2L)TE35B-15 (Gubb et al., 1985, McNabb et al., 1996) Df(2L)TE35B-48 (McNabb et al., 1996, Roote et al., 1996) Df(2L)TE35B-50 (Roote et al., 1996) Df(2L)TE35B-54 (McNabb et al., 1996, Roote et al., 1996) Df(2L)TE35B-54L (Roote et al., 1996, Roote, 1996.8, Gubb et al., 1997) Df(2L)TE35B-203 (Roote et al., 1996) Df(2L)TE35B-300 (Roote et al., 1996) Df(2L)TE35B-400 (Roote, 1995.3.27, Roote et al., 1996) Df(2L)TE35B-401 (Roote, 1995.3.27, Roote et al., 1996) Df(2L)TE35B-402 (Roote, 1995.3.27, Roote et al., 1996) Df(2L)TE35B-403 (Roote, 1995.3.27, Roote et al., 1996) Df(2L)TE35B-407 (Roote, 1995.3.27, Roote et al., 1996) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984, Davis et al., 1990, Davis et al., 1997) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35D-24 (Roote et al., 1996) Df(2L)W (Woodruff and Ashburner, 1979, Ashburner et al., 1982, McNabb et al., 1996) Dp(2;2)Cam12 (Roote, 1995.3.27, Roote et al., 1996, Gubb et al., 1997) In(2)TE35B-1a (Roote et al., 1996) In(2)TE35B-101 (Roote et al., 1996) In(2)TE35B-219 (Roote et al., 1996) In(2L)75c (Woodruff and Ashburner, 1979, Grau et al., 1984) In(2L)75cLC158.1R (Woodruff and Ashburner, 1979) In(2L)C158LScorv11R (Ashburner et al., 1983) In(2L)C158LScorv17R (Ashburner et al., 1983) In(2L)noc2 (Davis et al., 1997) In(2L)TE35B-1 (Roote et al., 1996) In(2L)TE35B-8 (Roote et al., 1996) In(2L)TE35B-9 (Roote et al., 1996) In(2L)TE35B-11 (Roote et al., 1996) In(2L)TE35B-13 (Gubb et al., 1985) In(2L)TE35B-16 (Roote et al., 1996) In(2L)TE35B-27 (Roote et al., 1996) In(2L)TE35B-55 (Roote et al., 1996) In(2L)TE35B-56 (Roote et al., 1996) In(2L)TE35B-63 (Roote et al., 1996) In(2L)TE35B-210 (Roote et al., 1996) In(2L)TE35B-210LC163.41R (Roote, 2004.3.1, Roote et al., 1996, Gubb et al., 1997) In(2L)TE35B-220 (Roote et al., 1996) In(2L)TE35B-225 (Roote et al., 1996) In(2L)TE35B-227 (Roote et al., 1996) In(2L)TE35B-400 (Roote et al., 1996) In(2LR)b81a2LDTD43R (Roote, 2000.7.3, Roote, 1995.3.27, Roote et al., 1996) In(2LR)D20Lnoc4R (Roote et al., 1996) In(2LR)el6LA379R (Roote et al., 1996) In(2LR)noc4 (Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) In(2LR)noc4LD6R (Roote et al., 1996) In(2LR)noc4LScorv9R (Ashraf et al., 1999, Ashburner and Harrington, 1984, Roote et al., 1996) In(2LR)noc4LTE35B-50R (Roote, 1995.3.27) In(2LR)noc7 (Davis et al., 1997) In(2LR)pkD1-rv1 (Roote, 1997.6.6) In(2LR)pkD1-rv4 (Roote, 1997.6.6) In(2LR)pkD1-rv5 (Roote, 1997.6.6) In(2LR)pkD1-rv6 (Roote, 1997.6.6) In(2LR)pkD1-rv7 (Roote, 1997.6.6) In(2LR)pkD1-rv9 (Roote, 1997.6.6) In(2LR)pkD1-rv2 (Roote, 1997.6.6) In(2LR)pkD1-rv3 (Roote, 1997.6.6) In(2LR)pkD1-rv8 (Roote, 1997.6.6) In(2LR)pkD1-rv10 (Roote, 1997.6.6) In(2LR)TE35B-4 (Roote et al., 1996) In(2LR)TE35B-4LTE35B-250R (Roote, 1997.6.6) In(2LR)TE35B-6 (Roote et al., 1996) In(2LR)TE35B-6LScorv9R (Ashburner and Harrington, 1984, Roote et al., 1996) In(2LR)TE35B-14 (Roote et al., 1996) In(2LR)TE35B-14LScorv1R (Roote et al., 1996, Roote, 1996.8) In(2LR)TE35B-15 (Roote et al., 1996) In(2LR)TE35B-15LScorv1R (Roote et al., 1996, Gubb et al., 1997) In(2LR)TE35B-50 (Roote et al., 1996) In(2LR)TE35B-205 (Roote et al., 1996) In(2LR)TE35B-222 (Roote et al., 1996) In(2LR)TE35B-223 (Roote et al., 1996) In(2LR)TE35B-226 (Roote et al., 1996) T(1;2;3)TE35B-100 (Roote et al., 1996) T(1;2)TE35B-217 (Roote et al., 1996) T(2;3)GT7 (Gubb et al., 1990) T(2;3)GT8 (Davis et al., 1990, Gubb et al., 1990, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) T(2;3)Scorv7 (Ashburner et al., 1983, Ashburner and Harrington, 1984, Grau et al., 1984) T(2;3)TE35B-2 (Roote et al., 1996) T(2;3)TE35B-2a (Chia et al., 1985) T(2;3)TE35B-3 (Roote et al., 1996) T(2;3)TE35B-3DG16P (Chia et al., 1985, Roote, 1995.3.27) T(2;3)TE35B-3a (Roote et al., 1996) T(2;3)TE35B-4 (Roote et al., 1996) T(2;3)TE35B-5 (Roote et al., 1996) T(2;3)TE35B-7 (Roote et al., 1996) T(2;3)TE35B-25 (Roote et al., 1996) T(2;3)TE35B-26 (Roote et al., 1996) T(2;3)TE35B-28 (Roote et al., 1996) T(2;3)TE35B-58 (Roote et al., 1996) T(2;3)TE35B-200 (Roote et al., 1996) T(2;3)TE35B-202 (Roote et al., 1996) T(2;3)TE35B-207 (Roote et al., 1996) T(2;3)TE35B-208 (Roote et al., 1996) T(2;3)TE35B-209 (Roote et al., 1996) T(2;3)TE35B-212 (Roote et al., 1996) T(2;3)TE35B-215 (Roote et al., 1996) T(2;3)TE35B-216 (Roote et al., 1996) T(2;3)TE35B-218 (Roote et al., 1996) T(2;3)TE35B-221 (Roote et al., 1996) T(2;3)TE35B-224 (Roote et al., 1996) T(2;3)TE35B-229 (Roote et al., 1996) T(2;3)TE35B-230 (Roote et al., 1996) T(2;3)TE35B-401 (Roote et al., 1996) T(2;4)TE35B-50 (Roote et al., 1996, Roote, 1996.8) T(2;4)TE35B-101 (Roote et al., 1996) T(2;4)TE35B-214 (Roote et al., 1996) T(Y;2)A80DR15P (Woodruff and Ashburner, 1979, Ashburner et al., 1982) T(Y;2)GT1 (Gubb et al., 1990) T(Y;2)TE35B-51 (Roote et al., 1996) T(Y;2)TE35B-102 (Roote et al., 1996) T(Y;2)TE35B-201 (Roote et al., 1996) T(Y;2)TE35B-204 (Roote et al., 1996) T(Y;2)TE35B-206 (Roote et al., 1996) T(Y;2)TE35B-211 (Roote et al., 1996) T(Y;2)TE35B-213 (Roote et al., 1996) Tp(1;2)TE35B (Ashburner et al., 1981, Gubb et al., 1985, Gubb et al., 1986, Harden and Ashburner, 1990, Lovering et al., 1991, Davis et al., 1997) Tp(1;2)TE35B-SZ5   Tp(2;2)A446 (Ashburner et al., 1982, Ashburner et al., 1982, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) Tp(2;2)TE35B-54 (Roote et al., 1996) Tp(2;3)TE35B-203 (Roote et al., 1996) Ts(2Lt;3Lt)H147+Ts(2Rt;3Rt)TE35B-8 (Roote et al., 1996) Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16 (Chia et al., 1985) Ts(2Lt;3Lt)TE35B-3+Ts(2Rt;3Rt)G16 (Roote et al., 1996, Gubb et al., 1997) Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984, Chia et al., 1985, Roote et al., 1996) Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)osp90 (Roote, 1995.3.27, Roote et al., 1996, Gubb et al., 1997) Ts(2Lt;3Lt)TE35B-28+Ts(2Rt;3Rt)pb-3a (Roote, 1995.3.27, Roote et al., 1996) Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13 (Ashburner et al., 1983) Ts(2Lt;3Rt)GT10+Ts(2Rt;3Lt)TE35B-209 (Roote, 1995.3.27, Roote et al., 1996) Ts(2Lt;4Lt)GT6+Ts(2Rt;4Rt)TE35B-101 (Roote, 1995.3.27, Roote et al., 1996) Ts(2Lt;4Lt)TE35B-50+Ts(2Rt;4Rt)DTD22 (Roote et al., 1996, Gubb et al., 1997) Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15 (Ashburner et al., 1981, Ashburner et al., 1982, Roote et al., 1996, Davis et al., 1997) Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)R15 (Davis et al., 1990, Roote et al., 1996, Gubb et al., 1997) Ts(YLt;2Lt)A80+Ts(Y;2Rt)TE35B-18 (Roote et al., 1996)
Duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1983) Ts(2Lt;4Lt)TE35B-101+Ts(2Rt;4Rt)GT6   Ts(YLt;2Lt)R15+Ts(Y;2Rt)el4 (Roote et al., 1996) Ts(YLt;2Lt)R15+Ts(Y;2Rt)TE35B-18 (Roote et al., 1996) Ts(YLt;2Lt)R15+Ts(YSt;2Rt)A80 (Roote et al., 1996)
Not duplicated in	Dp(2;1;f)Scorv23-X2   Dp(2;3)osp3 (Roote et al., 1996) In(2L)C163.41LC158R (Ashburner et al., 1982, Roote et al., 1996) Ts(Y;2Lt)TE35B-18+Ts(YSt;2Rt)A80 (Roote et al., 1996) Ts(YLt;2Lt)A80+Ts(Y;2Rt)el4 (Roote et al., 1996) Ts(YLt;2Lt)A80+Ts(YLt;2Rt)G74 (Roote et al., 1996)
Partially disrupted in	Df(2L)A178 (Fossett et al., 1994) Df(2L)A267 (Fossett et al., 1994, Roote et al., 1996) Df(2L)A379 (Fossett et al., 1994, Roote et al., 1996) Df(2L)A445 (Fossett et al., 1994, Roote et al., 1996) Df(2L)Adh-nBR106 (Roote et al., 1996) Df(2L)Adh-nBR119 (Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR126 (Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)ED3 (Ryder et al., 2007) Df(2L)fn27 (Roote et al., 1996) Df(2L)nNxF1 (Roote et al., 1996, Roote, 1996.8) Df(2L)nNxF2 (Roote et al., 1996) Df(2L)osp144 (Roote et al., 1996) Df(2L)PA4 (Roote et al., 1996) Df(2L)Scorv4 (Roote et al., 1996) Df(2L)Scorv10 (Roote et al., 1996) Df(2L)Scorv14 (Roote et al., 1996) Df(2L)Scorv18 (Roote et al., 1996) Df(2L)Scorv25 (Roote et al., 1996) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35BC-7 (Roote et al., 1996) Df(2L)TE35D-20 (Roote et al., 1996) In(2L)noc2 (Roote et al., 1996) In(2L)Scorv8 (Roote et al., 1996) In(2L)Scorv24 (Roote et al., 1996) In(2LR)noc7 (Roote et al., 1996) In(2LR)pkD1-rv11 (Roote, 1997.6.6) In(2LR)pkD1-rv12 (Roote, 1997.6.6) In(2LR)Scorv1 (Roote et al., 1996) In(2LR)Scorv9 (Roote et al., 1996) T(2;3)Scorv7 (Roote et al., 1996) Tp(1;2)TE35B-GR17   Tp(2;2)A446 (Fossett et al., 1994) Tp(2;2)Sco (Roote et al., 1996) Tp(2;2)Scorv12 (Roote et al., 1996) Tp(3;2)osp204 (Roote et al., 1996) Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16 (Roote et al., 1996)
Not disrupted in	Df(2L)A48 (Ashburner et al., 1982, Ashburner et al., 1982, Gubb et al., 1990, Grau et al., 1984, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996) Df(2L)A63 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996) Df(2L)A72 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996) Df(2L)A220 (Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996) Df(2L)A264 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR106 (Fossett et al., 1994) Df(2L)Adh-nBR107 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR111 (Fossett et al., 1990) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR122 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR128 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)b75 (Woodruff and Ashburner, 1979, Gubb et al., 1990) Df(2L)b80e3 (Ashburner et al., 1982, Roote et al., 1996) Df(2L)b83d29a (Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) Df(2L)b84a2 (Davis et al., 1990, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)b88h49 (Roote et al., 1996) Df(2L)el94 (Roote, 1996.1.11, Roote, 1996.8) Df(2L)fn3 (Woodruff and Ashburner, 1979) Df(2L)fn27 (Davis et al., 1997) Df(2L)fn52 (Roote, 1996.8) Df(2L)osp18 (McNabb et al., 1996) Df(2L)osp29 (Ashburner et al., 1982, Grau et al., 1984, McNabb et al., 1996, Roote et al., 1996) Df(2L)osp201 (McNabb et al., 1996) Df(2L)SS1 (Grau et al., 1984) Df(2L)TE35BC-1 (Gubb et al., 1984) Df(2L)TE35BC-3 (Ashburner et al., 1982, Gubb et al., 1984, Grau et al., 1984) Df(2L)TE35BC-4 (Ashburner et al., 1982, Gubb et al., 1984, McNabb et al., 1996, Roote et al., 1996) Df(2L)TE35BC-24 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984, McNabb et al., 1996) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984, McNabb et al., 1996) In(2L)C158 (McNabb et al., 1996) In(2L)C158LScorv11R (Ashburner and Harrington, 1984) In(2L)C158LScorv17R (Ashburner and Harrington, 1984) In(2L)el9 (Davis et al., 1990) In(2L)osp22 (McNabb et al., 1996) In(2L)osp59 (McNabb et al., 1996) In(2L)Scorv11 (Roote et al., 1996) In(2L)Scorv17 (Roote et al., 1996) In(2LR)DTD128 (Davis et al., 1990) In(2LR)el6 (Davis et al., 1990) T(2;3)dpps19 (Davis et al., 1990) T(2;3)el24 (Davis et al., 1990, Roote et al., 1996) T(2;3)GT7 (Roote et al., 1996) T(2;3)GT10 (Davis et al., 1990) T(2;3)H47 (McNabb et al., 1996) T(2;3)Mpe (McNabb et al., 1996, Davis et al., 1997) T(2;3)osp90 (McNabb et al., 1996) T(2;3)TE35B-2a (Chia et al., 1985) T(2;3)TE35BC-3 (McNabb et al., 1996) T(Y;2)a15 (Davis et al., 1990) T(Y;2)A80 (Davis et al., 1990) T(Y;2)el4 (Davis et al., 1990) T(Y;2)GT1 (Roote et al., 1996, Davis et al., 1997) T(Y;2)GT2 (Davis et al., 1990) T(Y;2)J165DP58P (Woodruff and Ashburner, 1979) T(Y;2)R15DJ165P (Woodruff and Ashburner, 1979) T(Y;2)TE35B-18 (Roote et al., 1996) Tp(2;3)GT3 (Davis et al., 1990) Tp(2;3)osp3 (McNabb et al., 1996) Tp(2;3)pb3 (McNabb et al., 1996) Ts(2Lt;3Lt)dpps19+Ts(2Rt;3Rt)el24 (Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Ts(2Lt;3Lt)Mpe+Ts(2Rt;3Rt)G16 (Chia et al., 1985) Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984, McNabb et al., 1996) Ts(Y;2Lt)a15+Ts(YSt;2Rt)A80 (Davis et al., 1997) Ts(Y;2Lt)el4+Ts(YSt;2Rt)A80 (Roote et al., 1996) Ts(Y;2Lt)GT2+Ts(YSt;2Rt)A80 (Roote et al., 1996, Davis et al., 1997)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1497} NA P{KK109977} NA P{NIG.4491R} NA P{TRiP.JF02534} NA P{UAS-noc.D} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}nocEP2000 NA P{EP}nocEP2173 NA P{EPgy2}EY00954 NA insertion of enhancer trap P{lacW}l(2)SH0905SH0905 No miscellaneous insertions I{}nocSco-like NA P{GT1}nocBG01916 NA P{SUPor-P}KG01719 NA insertion of enhancer trap binary system P{GAL4}nocGAL4 No P{GalW}ND750 No P{GalW}ND758 No
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 10 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with elB (Dorfman et al., 2002)
Biological Process
CV term Evidence References
brain development inferred from mutant phenotype (assigned by UniProtKB) (Cheah et al., 1994) cell proliferation inferred from genetic interaction with elB (Luque and Milan, 2007) eye-antennal disc development inferred from genetic interaction with elB (Luque and Milan, 2007) inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) leg disc development inferred from mutant phenotype (assigned by UniProtKB) (Weihe et al., 2004) negative regulation of gene expression inferred from mutant phenotype (Dorfman et al., 2002) ocellus development inferred from mutant phenotype (assigned by UniProtKB) (Cheah et al., 1994) open tracheal system development inferred from mutant phenotype (Dorfman et al., 2002) wing disc development inferred from mutant phenotype (assigned by UniProtKB) (Weihe et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase II promoter inferred from sequence or structural similarity (Ashburner et al., 1999)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Ashburner et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions noc allele Gene References nocd64 elB (Weihe et al., 2004) nocSco elA (Davis et al., 1997) elB (Davis et al., 1997, Ashburner et al., 1999) Pino (Anholt et al., 2003) smi26D (Anholt et al., 2003) unspecified L (Singh et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60871 DroID - A comprehensive database of gene and protein interactions. • FBgn0005771 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34847
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68SHF0 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG60K6V7 Arthropod inclusive ortholog search EOG68W9HC Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG68SHF0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\noc     Drosophila simulans   Dsim\GD23964 Y   Drosophila sechellia   Dsec\GM15623 Y   Drosophila erecta   Dere\GG25118 Y   Drosophila yakuba   Dyak\GE19034 Y   Drosophila ananassae   Dana\GF14886 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18219 Y   Drosophila persimilis   Dper\GL25989 Y   Drosophila willistoni   Dwil\GK18287 Y   Drosophila virilis   Dvir\GJ18020 Y   Drosophila mojavensis   Dmoj\GI10311 Y   Drosophila grimshawi   Dgri\GH23905 Y   Drosophila grimshawi   Dgri\GH13513
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG60K6V7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408265   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005518   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18582   Atta cephalotes Leafcutter ant  Acep\ACEP10174   Camponotus floridanus Florida carpenter ant  Cflo\CFLO25141   Camponotus floridanus Florida carpenter ant  Cflo\CFLO25139   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL26408   Linepithema humile Argentine ant  Lhum\LH14186   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20955   Solenopsis invicta Red fire ant  Sinv\SINV18553   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008359   Bombyx mori Silkmoth  Bmor\BGIBMGA008080   Pediculus humanus Human body louse  Phum\PHUM126330   Tribolium castaneum Red flour beetle  Tcas\noc
Orthologs in non-Insect Arthropods (EOG68W9HC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_98257   Ixodes scapularis Deer tick  Isca\ISCW005133
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23964 Drosophila sechellia Dsec\GM15623 Drosophila erecta Dere\GG25118 Drosophila yakuba Dyak\GE19034 Drosophila ananassae Dana\GF14886 Drosophila pseudoobscura pseudoobscura Dpse\GA18219 Drosophila persimilis Dper\GL25989 Drosophila willistoni Dwil\GK18287 Drosophila virilis Dvir\GJ18020 Drosophila mojavensis Dmoj\GI10311 Drosophila grimshawi Dgri\GH23905
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	29370 y1 v1; P{TRiP.JF02534}attP2 2291 z1 w1; b1 nocTE35B/CyO 4757 noc35Ba-2 Adhn11 cn1 vg1/CyO 4520 Dp(2;2)Cam10, dpov1 b1 nocTE35B pr1 cn1 bw1/CyO, Df(2L)noc20 9195 z1 w11E4; T(Y;2)TE35B-18, Dp(1;2)TE35B, y+ al1 dpov1 b1 nocTE35B w+ rst+ Cul-3GR18 pr1 pwn1 cn1/In(2LR)Gla, wgGla-1 DNApol-γ352 vg1
Kyoto	106763 z1 w1; b1 nocTE35B/CyO 101396 CyO, Cy1 dplv1 pr1 cn2 / noc35Ba-1 Adhn11 pr1 107774 Dp(2;2)Cam10, (al1) dpov1 b1 nocTE35B pr1 cn1 bw1 / CyO, Df(2L)noc20 101389 CyO, Cy1 dplv1 pr1 cn2 / In(2LR)noc4, b1 noc4 cn1 bw1
VDRC	v108422 P{KK109977}VIE-260B
Genomic Clones ( 1 )
	BACR21J17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 150 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28078
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM07914 LD28077 LD36001 LP01795 LP02940 LP04677 LP06007 LP19553 RE11524 RE15308 RE15883 RE20067 RE23321 RE24654 RE34579 RE45434 RE48358 RE50076 RE51733 RE67834 RE68810 RH19614
Other clones	28367 28836 55213 57121 66810 70965 74726 104401 106618 118602 120332 121398 122035 145591 158185 162438 162444 175583 175674 180017 274913 CK01.3C.G6 CK01.8A.F1 CK01.9C.H4 CK01.55C.G3 CK01.78D.D5 CK01.124A.A6 EK044826 EK051423 EK061212 EK145206 EK170729 EK173148 EK174239 EK183053 EK185960 EK188519 EK191902 EK194935 EK200060 EK204003 EK219003 EK227744 EK238028 EK241456 EK242317 EK244212 EK250305 EK251517 EK260861 EK266134 EK280159 EK291543 EK302834 FGM237G03 RE01633 RP003002251 RP003026081 RP003057291 RP003069641 RP003069881 RP003072107 RP003098356 RP003105052 RP003113445 RP003113768 RP003126359 RP003130508 RP003135101 RP003135906 RP003137407 RP003138597 RP003144828 RP003145511 RP003150399 RP003151966 RP003153507 RP003157869 RP003172697 RP003180489 RP003206048 RP003216370 RP003217953 RP003232069 RP003240885 RP003250105 RP003252810 RP003252951 RP003257711 RP003260713 RP003261119 RP003267936 RP003282898 RP003283421 RP003283673 RP003297951 RP003304736 RP003307892 RP003309495 RP003322444 RP003347884 RP003355435 RP003355589 RP003357853 RP003374873 RP003381975 RP003408393 RP003437248 RP003446301 RP003466470 RP003468675 RP003483194 RP003498442 RP003508887 RP003531977 RP003562216 RP003579025 RP003582292 RP003597039 RP003616154 RP003619610 RP003644348 RP003656030 RP003659556 RP003659891 RP003669858 RP003673054
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005771 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34847
Antibody Information
Other Information
Discoverer
	Ashburner.
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: noc CG4491 (Kodira, 1999.11)
Source for database merge of
Additional comments	The "Sco" (Scutoid) mutant allele was previously listed as an allele of noc in FlyBase, as genetic analysis showed that a high dose of the wild-type noc gene suppresses the expressivity of the Sco phenotype, suggesting that Sco was an antimorphic allele of noc (FBrf0038047). However, FBrf0111871 shows that Sco is in fact an antimorphic allele of sna, and the mutant phenotype is caused by ectopic expression of sna in the eye-antennal and wing imaginal discs.  The Sco allele is therefore now listed as an allele of sna in FlyBase.  FBrf0111871 suggests that the reason that noc in trans affects the expressivity of Sco may be due to transvection effects, as they show that mutations in z, a mediator of transvection, also affect the Sco mutant phenotype. (FlyBase, 1992-)
Other Comments
	Loss of elB and noc activities induce extensive outgrowths, in a N-dependent way. These overgrowths are not linked to ectopic production of os. (Luque and Milan, 2007) noc appears, with elB, to regulate the growth of the highly proliferative tissue of the eye-head primordium. (Luque and Milan, 2007)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057569 RefSeq (Proteins) • NP_476917 DDBJ / EMBL / GenBank • AA696574 AA949253 AA949254 AAA16473 AAF44877 AAF53399 AAL48021 AC092228 AE003410 AQ073367 AQ074104 AW942795 AY070550 L14009 Entrez Gene - A searchable database of RefSeq genes. • 34847 UniProtKB/Swiss-Prot • Q24423
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD28078
Linkouts
	BioGRID - A database of protein and genetic interactions • 60871 DroID - A comprehensive database of gene and protein interactions. • FBgn0005771 DRSC - Results from RNAi screens. • FBgn0005771 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005771 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4491-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005771 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34847 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34847 modMine - Data generated by the modENCODE project. • FBgn0005771
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	BG:DS04641.1 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) br22 (Ashburner and Harrington, 1984, Grau et al., 1984, Gubb et al., 1985) CG4491 (Hadar et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Weber et al., 2012) el (Luque and Milan, 2007) l35Ba (Fossett et al., 1994) l(2)35Ba (Davis, 2003.5.6, Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1997, Alexandrova et al., 1996, Dubin et al., 1995, Fossett et al., 1990, Gubb et al., 1990, Davis et al., 1990, ) l(2)35Ba/nocA (Cheah et al., 1994) l(2)br22 (Ashburner et al., 1982, Ashburner et al., 1983, Gubb et al., 1984, Gubb et al., 1986) noc (Kazemian et al., 2011, Hadar et al., 2012, Negre et al., 2006, Ryder et al., 2007, Perea et al., 2009, Hou et al., 2009, Cook and Cook, 2010.2.17, Engström et al., 2007, Specchia et al., 2010, Tom et al., 2011, Gutiérrez et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Weber et al., 2012) Noc (Terriente et al., 2008, Michaut et al., 2011) nocA (Davis, 2003) nocA (Ainsley et al., 2003, Glazer et al., 2000, Cheah, 1993, Fossett et al., 1994)
Name Synonym	no ocelli (Luque and Milan, 2007, Negre et al., 2006, Terriente et al., 2008, Perea et al., 2009, Edwards et al., 2009, Hou et al., 2009, Harbison and Sehgal, 2008) no-ocelli (Tom et al., 2011)
Secondary FlyBase IDs
	FBgn0001971 FBgn0002947
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 67 ) Supplementary material  ( 8 ) Review  ( 3 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 2 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Book  ( 1 )
Recent research papers ( 8 )
	Gutiérrez et al., 2012, Development 139(1): 117--127 The role of the histone H2A ubiquitinase Sce in Polycomb repression. [FBrf0216868] Hadar et al., 2012, Gene 494(1): 65--72 A screen identifying genes responsive to Dpp and Wg signaling in the Drosophila developing wing. [FBrf0217293] Weber et al., 2012, Genetics 191(1): 145--162 Novel regulators of planar cell polarity: a genetic analysis in Drosophila. [FBrf0218210] Zeng et al., 2012, Nucleic Acids Res. 40(13): 5848--5863 Genome-wide polycomb target gene prediction in Drosophila melanogaster. [FBrf0218974] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Kazemian et al., 2011, Nucleic Acids Res. 39(22): 9463--9472 Improved accuracy of supervised CRM discovery with interpolated Markov models and cross-species comparison. [FBrf0216971] Michaut et al., 2011, Dev. Growth Differ. 53(9): 982--993 Analyzing the function of a hox gene: An evolutionary approach. [FBrf0216990] Tom et al., 2011, Mol. Cell. Neurosci. 46(1): 252--261 Disruption of olfactory receptor neuron patterning in Scutoid mutant Drosophila. [FBrf0212698] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...