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Gene Dmel\noc

General Information
Symbol	Dmel\noc	Species	D. melanogaster
Name	no ocelli	Annotation symbol	CG4491
Feature type	protein_coding_gene	FlyBase ID	FBgn0005771
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35B2-35B2	Sequence location	2L:14,490,862..14,494,019 [+]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene no ocelli is referred to in FlyBase by the symbol noc (CG4491, FBgn0005771). It has the cytological map location 35B2. Its sequence location is 2L:14490862..14494019. Its molecular function is described as: RNA polymerase II transcription factor activity; zinc ion binding. It is involved in the biological processes: regulation of transcription from RNA polymerase II promoter; open tracheal system development. 52 alleles are reported. The phenotypes of these alleles are annotated with 16 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult; embryonic/larval tracheal system; adult segment; adult mesothoracic segment; head capsule; embryonic dorsal branch; adult brain; adult external prothorax; embryonic ganglionic branch; postalar bristle. It has one annotated transcript and one annotated polypeptide.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)35Ba l(2)35Ba1 may escape in combination with deficiency for the locus; escapers are weak elbow in phenotype if deficiency includes el, but not if it does not. All alleles express weak elbow in combination with el1; heteroallelic escapers [i.e., l(2)35Ba4 in combination with other alleles] are weak elbow. Semilethal with In(2LR)Scorv1 and Scorv27; also show weak noc phenotype in combination with strong noc alleles. noc: no ocelli The genetic complexity of noc is indicated by phenotypic as well as molecular data (McGill et al., 1988). Mutants are characterized by partial or complete absence of ocelli and their associated bristles. Strong noc alleles lack all three ocelli and have fewer interocellar microchaetae; ocellar and interocellar bristles are absent; anterior postalar and notopleural bristles may not be present; postvertical bristles are crooked, an adventitious pair often occurring between a normal pair. Weak alleles may overlap wild type in phenotype, the flies having smaller ocelli and an aberrant pattern of interocellar microchaetae. Male and female homozygotes are viable and fertile. Penetrance and expressivity is stronger in males and in flies that emerge later. While a homozygous deletion of the entire noc region is lethal, distal or proximal regions can be homozygously deleted without causing lethality. Some noc alleles and deficiences are lethal with In(2L)Scorv1, whose 2L breakpoint lies within noc, while other alleles are viable with the Sco inversion. Sco: Scutoid Sco/+ flies exhibit the loss of 10-15 bristles, scutellars, notopleurals, upper humerals and anterior postalars being most frequently affected; removes both trichogen and tormogen cell derivatives. Homozygotes nearly lethal; rare homozygous or hemizygous escapers have only eight or so bristles per fly; eyes small and very rough. Escapers short lived and sterile. RK1A.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35B2-35B2   Limits computationally determined from genome sequence between P{EP}elBEP2039&P{PZ}osprJ571 and P{lacW}Su(H)k07904
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35A4-35A4 (determined by in situ hybridisation)   (McGill et al., 1988) 35B1-35B2 (determined by in situ hybridisation)   (Chia et al., 1985)
Experimentally Determined Recombination Data
Location	2- (Krivshenko, 1959) 2-51.0 (Tomkiel et al., 1995)
Left of (cM)
Right of (cM)	abo J (Tomkiel et al., 1995)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References In direction of increasing cytology: CG15283- noc+ tRNA:P:35Bd+ (Ashburner et al., 1999) Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\noc for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) noc-RA FBtr0080643  NM_057569   2856   537
Additional Transcript Data & Comments
Reported size (kB)	~3 (northern blot) (Cheah et al., 1994)
Comments	The two noc transcripts differ only the length of the 3\\' untranslated region (one is 236 bases longer) and have at least one intron of ~250 bases. (Cheah et al., 1994)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein noc-PA   FBpp0080215   54.0   537   9.13     NP_476917   AAF53399
Additional Polypeptide Data & Comments
Reported size (kD)	537 (aa) (Cheah et al., 1994)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0005771
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2-type (IPR007087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA696574   AA949253   AA949254   AC092228   AE003410 AAF44877   AE003644 AAF53399   AI257598   AI258572   AI259511   AI260716   AI456142   AQ073367   AQ074104   AW942795   AY070550 AAL48021   BI162269   BI162270   BI170157   BI172667   BI173140   BI214300   BI227568   BI231701   BI238185   BI358605   BI363528   BI364884   BI366236   BI484693   BI485479   BI581805   BP555890   CK660728   CO176866   CO189651   CO266165   CO285932   CO292386   CO293641   CO297854   CO298510   CO298987   CO303447   CO303650   CO304254   CO306584   CO309730   CO314849   CO315271   CO316906   CO319733   CO321588   CO322620   CO323905   CO324833   CO332224   EC058410   EC059716   EC063381   EC066559   EC068423   EC072306   EC077349   EC079953   EC080791   EC085907   EC086503   EC088074   EC089473   EC089926   EC089930   EC194567   EC203084   EC203147   EC204561   EC204711   EC211388   EC211496   EC212653   EC213791   EC214273   EC221134   EC226060   EC226705   EC228172   EC229028   EC249014   L14009 AAA16473   RE01633
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24423
Maps to	DS04641 (Ashburner et al., 1999.10.12) FBcl0297547 (FlyBase, 1992-)
Does NOT map to
Identified with	GM07914 (Ashburner et al., 1999, Ashburner et al., 1999.10.12) LD28077 (Ashburner et al., 1999.10.12) LD28078 (Ashburner et al., 1999.10.12, BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References aberration junction Tp(2;2)A446.bk1 2L:14,492,811..14,496,471 evidence=experimental linked_to=SstI-SstI_rfrag comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator (Chia et al., 1985) aberration junction In(2LR)noc[4].bk1 2L:14,496,466..14,501,864 evidence=experimental linked_to=SstI-HindIII_rfrag comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator (Chia et al., 1985) aberration junction Df(2L)A178.bk1 2L:14,497,086..14,499,160 evidence=experimental linked_to=SalI-SalI_rfrag comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator (Chia et al., 1985) aberration junction Tp(1;2)TE35B.bk3 2L:14,501,859..14,502,617 evidence=experimental linked_to=HindIII-SalI_rfrag comment=aberration breakpoint localized to a restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator (Chia et al., 1985)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 7665
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage | stage 5   (Cheah et al., 1994)  embryonic stage | stage 8-12  labral segment (Cheah et al., 1994)  embryonic stage | stage 8-12  stomodeum (Cheah et al., 1994)  embryonic stage | stage 10-12  tracheal placode | surrounding (Cheah et al., 1994)  embryonic stage-adult stage   (Cheah et al., 1994)  embryonic stage | stage 5   (Cheah et al., 1994)  embryonic stage | stage 5-6  ectoderm | stripes (Cheah et al., 1994)  embryonic stage | stage 8  ventral neurectoderm (Cheah et al., 1994)  embryonic stage | stage 8-12  procephalic segment (Cheah et al., 1994)  embryonic stage | stage 9  neurectoderm | stripes (Cheah et al., 1994)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Microarray Data
	Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) AA949254
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005771 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0005771 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0005771 BDGP expression data • Show all BDGP original images, annotations and embryonic microarray data for noc FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for noc Stage(s) 4-6 Stage(s) 7-8 Stage(s) 9-10 Stage(s) 11-12 Stage(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable nocTE35B lethal | recessive noc35Ba-1 noc35Ba-4 nocSZ5 nocSco-rv15 nocSco lethal | larval stage | recessive noc35Ba-1 noc35Ba-2 noc35Ba-3 noc35Ba-4 Other Phenotypes Allele visible | recessive noc2 noc4 noc7 nocTE35B visible | dominant nocSco-rv8 nocSco Phenotype manifest in Allele ocellus noc2 noc4 nocTE35B anterior postalar bristle noc2 nocTE35B microchaeta noc2 nocTE35B postvertical bristle noc2 noc7 ocellar bristle noc2 noc7 nocSco nocTE35B lateral ocellus noc2 noc7 supraesophageal ganglion noc35Ba-1 noc35Ba-2 noc35Ba-3 head bristle noc4 nocTE35B medial ocellus noc7 macrochaeta nocGT8 chaeta nocSco head bristle | dorsal nocSco scutellar bristle nocSco nocSco-rv8 humeral bristle nocSco lateral trunk anterior branch nocd64 embryonic ganglionic branch nocd64 embryonic dorsal branch nocd64
Classical Alleles ( 49 )
For All Classical Alleles Show
Allele of noc Class Mutagen Stocks Known lesion noc14 γ ray 0 -- noc15 γ ray 0 -- noc18 ethyl methanesulfonate 0 -- noc19 ethyl methanesulfonate 0 -- noc21 γ ray 0 -- noc22 ethyl methanesulfonate 0 -- noc23 ethyl methanesulfonate 0 -- noc2 ethyl methanesulfonate 0 Yes noc35Ba-1 ethyl methanesulfonate 1 -- noc35Ba-2 ethyl methanesulfonate 1 -- noc35Ba-3 ethyl methanesulfonate 0 -- noc35Ba-4 ethyl methanesulfonate 0 -- noc4 γ ray 1 Yes noc6 γ ray 0 -- noc7 γ ray 0 Yes nocA178 0 Yes nocA446 0 Yes nocEP2000 P-element activity 1 -- nocEP2173 P-element activity 1 Yes nocGAL4 0 Yes nocGT8 γ ray X ray 1 -- nocSZ5 spontaneous 0 -- nocSco-rv11 X ray 0 -- nocSco-rv12 X ray 0 -- nocSco-rv13 X ray 0 -- nocSco-rv15 ethyl methanesulfonate 0 -- nocSco-rv17 X ray 0 -- nocSco-rv1 X ray 0 -- nocSco-rv21 X ray 0 -- nocSco-rv23 X ray 0 -- nocSco-rv24 X ray 0 -- nocSco-rv26 X ray 0 -- nocSco-rv27 X ray 0 Yes nocSco-rv2 X ray 0 -- nocSco-rv5 X ray 0 -- nocSco-rv8 X ray 0 -- nocSco-rv9 X ray 0 -- nocSco X ray 88 Yes nocTE35B-50 0 Yes nocTE35B-54L 0 Yes nocTE35B amorph spontaneous 4 Yes nocd64 Δ2-3 0 Yes nocel-1 0 -- nocnBR106 <up>3</up>H 0 -- nocnBR119 <up>3</up>H 0 -- nocnBR126 <up>3</up>H 0 -- nocnNxF1 0 -- nocnNxF2 0 -- nocosp144 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of noc Class Mutagen Stocks Known lesion nocGD1497 in vitro construct | RNAi in vitro construct | regulatory fusion 0 Yes nocScer\UAS.cDa in vitro construct | regulatory fusion 0 Yes nocdsRNA.cTa in vitro construct | RNAi 0 Yes
Aneuploid Aberrations
Useful deficiency	Df(2L)A260
Useful duplication	Dp(2;2)GYL
Disrupted in	Df(2L)64j (O'Donnell et al., 1977, Woodruff and Ashburner, 1979, Woodruff and Ashburner, 1979) Df(2L)A178 (Ashburner et al., 1982, Ashburner et al., 1982, Cheah et al., 1994, Roote et al., 1996, Davis et al., 1997) Df(2L)A215 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A217 (Ashburner et al., 1982, Fossett et al., 1994, McNabb et al., 1996) Df(2L)A245 (Ashburner et al., 1982, Davis et al., 1990, Cheah et al., 1994, Fossett et al., 1994, McNabb et al., 1996, Roote et al., 1996) Df(2L)A246 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A260 (Ashburner et al., 1982,