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Gene Dmel\Con

General Information
Symbol	Dmel\Con	Species	D. melanogaster
Name	Connectin	Annotation symbol	CG7503
Feature type	protein_coding_gene	FlyBase ID	FBgn0005775
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	conn
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64C2-64C5	Sequence location	3L:4,936,758..5,079,033 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Connectin is referred to in FlyBase by the symbol Dmel\Con (CG7503, FBgn0005775). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: homophilic cell adhesion. 16 alleles are reported. The phenotypes of these alleles are annotated with: organ system; ISN innervated muscle of A1-7; hypodermal muscle of larval abdomen; embryonic/larval neuron; abdominal 7 longitudinal muscle; hypodermal muscle of larval abdominal 2; abdominal 4 ventral oblique muscle 4; abdominal 7 ventral longitudinal muscle 2; abdominal 1 ventral oblique muscle 4; organ system subdivision. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cysteine-rich flanking region, C-terminal; Leucine-rich repeat; Leucine-rich repeat, typical subtype. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1639913_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Con. Gene sequence location is 3L:4936758..5079033.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Controlled Vocabulary Terms A1-7 VO2 motor neuron
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64C2-64C5   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64C3-64C5   (determined by in situ hybridisation)   (Nose et al., 1994) 64C-64C   (determined by in situ hybridisation)   (Gould and White, 1992) 64C-64C   (determined by in situ hybridisation)   (Nose et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Con for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Con-RA FBtr0073375  NM_079206   3758   691 Con-RB FBtr0309972  NM_001259706   5588   691
Additional Transcript Data & Comments
Reported size (kB)	5 (northern blot) (Gould and White, 1992) 5.0 (northern blot) (Nose et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Con-PA   FBpp0073231   77.2   691   7.05     NP_523930   AAF47952 Con-PB   FBpp0301699   77.2   691   7.05     NP_001246635   AFH04306
Additional Polypeptide Data & Comments
Reported size (kDa)	682 (aa); 76 (kD) (Nose et al., 1992) 682 (aa); 72 (kD predicted) (Gould and White, 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cysteine-rich flanking region, C-terminal (IPR000483) Leucine-rich repeat, typical subtype (IPR003591) Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140932   AA140963   AA141121   AA141124   AA141127   AA141143   AA141196   AA141199   AA141201   AA141234   AA141323   AA141354   AA141371   AA141408   AA141422   AA141464   AA141478   AA141489   AA141497   AA141560   AA141562   AA141607   AA141609   AA141611   AA141655   AA141676   AA141689   AA141707   AA141711   AA141735   AA141736   AA141743   AA141834   AA141881   AA142178   AA440163   AA697478   AA698569   AE014296 AAF47952   AE014296 AFH04306   AI108376   AI108939   AI124308   AI134790   AI238476   AI296338   AI387761   AI531290   AI546631   AI946374   AW940556   AY119518 AAM50172   BE975941   BE976076   BG632363   BG632682   BG640306   BH900960   BI142244   BI165760   BI166453   BI170191   BI171371   BI214728   BI352942   BI374660   BI486635   BI563882   BI564851   BI565487   BI566395   BI571886   BI573700   BI574131   BI575214   BI576026   BI576319   BI577030   BI581919   BI582174   BI582454   BI583280   BI583851   BI583993   BI584901   BI586861   BI588375   BI588406   BI588459   BI588663   BI588668   BI588766   BI588884   BI589090   BI589239   BI589243   BI590672   BI590731   BI592794   BI593032   BI604445   BI605511   BI606547   BI607294   BI607877   BI607977   BI608784   BI608982   BI610522   BI610661   BI611018   BI611097   BI611159   BI611230   BI611710   BI611827   BI612977   BI613020   BI613394   BI613754   BI615370   BI615509   BI616145   BI616581   BI616610   BI616906   BI617028   BI617090   BI617439   BI617684   BI618824   BI619653   BI620053   BI620538   BI620781   BI621147   BI621284   BI622500   BI622740   BI623088   BI623093   BI623319   BI623627   BI624745   BI625317   BI625766   BI625785   BI625802   BI626050   BI626350   BI626426   BI626450   BI626871   BI627441   BI627518   BI628367   BI628419   BI628426   BI628436   BI628544   BI629001   BI629190   BI629211   BI629381   BI630149   BI630924   BI631188   BI631763   BI631785   BI631828   BI631848   BI631900   BI631995   BI634197   BI634339   BI634950   BI635165   BI636622   BI641728   BP555729   BT015228   BT125767   BT132769   CK135090   CK135119   CK135361   CO153056   CO153494   CO177555   CO179042   CO179169   CO179305   CO187196   CO187484   CO187678   CO187710   CO187913   CO188410   CO188829   CO189129   CO190350   CO190469   CO190773   CO190982   CO195863   CO261955   CO262568   CO263244   CO263592   CO264634   CO265429   CO266208   CO266621   CO267454   CO267553   CO268027   CO268650   CO269696   CO271850   CO271971   CO272605   CO272787   CO274206   CO274786   CO275125   CO275338   CO275347   CO275570   CO275968   CO276551   CO278383   CO278479   CO279082   CO280371   CO280443   CO281966   CO282275   CO282855   CO283430   CO284008   CO284265   CO284404   CO286623   CO287499   CO290009   CO290180   CO290679   CO290759   CO291316   CO291587   CO291788   CO291860   CO292855   CO293512   CO293878   CO294202   CO294380   CO294540   CO295238   CO297010   CO300381   CO300478   CO302049   CO302309   CO302349   CO302681   CO303318   CO303356   CO303980   CO304026   CO304946   CO307131   CO308453   CO309390   CO309805   CO310496   CO311125   CO311647   CO311693   CO311933   CO312111   CO312182   CO315577   CO316352   CO316667   CO317096   CO317213   CO317355   CO319487   CO319523   CO319903   CO320976   CO320977   CO321140   CO322033   CO324658   CO324776   CO326836   CO326862   CO327048   CO327604   CO328187   CO328257   CO328314   CO328588   CO328871   CO329111   CO330975   CO331217   CO331792   CO332493   CO332733   CO333387   CO337673   CO338699   CO338920   CO339169   CO339547   CO339604   CO340021   CO340197   CO340225   CO340355   CO340387   CO340748   CO340851   CO340882   CO340913   CO340947   CO341122   CO341778   CO341986   CO342406   CO343368   CO343580   CO343721   CO344264   CO344379   CO344766   CO344971   EC053663   EC055739   EC060679   EC061814   EC062033   EC067301   EC078578   EC213505   EC233815   EC241226   EC244637   EC251256   EC257658   M96647 AAA28424   X68701 CAA48652
UniProtKB/Swiss-Prot	Q01819
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000436017 3L:4,929,622..4,930,659 evidence=Reporter construct (in vivo) (Gould and White, 1992, Halfon, 2012.6.19) regulatory region FBsf0000436775 3L:4,929,622..4,933,552 evidence=Reporter construct (in vivo) (Gould and White, 1992, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   visceral mesoderm   (Nose et al., 1992) presumptive embryonic/larval central nervous system | restricted   (Nose et al., 1992) abdominal 1 lateral transverse muscle 4 -- abdominal 7 lateral transverse muscle 4   (Nose et al., 1992) abdominal 1 lateral transverse muscle 2 -- abdominal 7 lateral transverse muscle 2   (Nose et al., 1992) abdominal 1 ventral acute muscle 2 -- abdominal 7 ventral acute muscle 2   (Nose et al., 1992) abdominal 1 lateral oblique muscle 1 -- abdominal 7 lateral oblique muscle 1   (Nose et al., 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   neuron   (Nose et al., 1992) abdominal 1 lateral transverse muscle 1 -- abdominal 7 lateral transverse muscle 1   (Nose et al., 1992) somatic muscle   (Nose et al., 1992) abdominal 1 lateral transverse muscle 3 -- abdominal 7 lateral transverse muscle 3   (Nose et al., 1992) abdominal 1 dorsal transverse muscle 1 -- abdominal 7 dorsal transverse muscle 1   (Nose et al., 1992) embryonic/larval sense organ of embryonic gnathal segment   (Gould and White, 1992) abdominal 1 ventral acute muscle 3   (Nose et al., 1992) embryonic stage 10   visceral mesoderm | presumptive   (Gould and White, 1992) embryonic stage 11   circular visceral muscle primordium   (Gould and White, 1992) hindgut proper primordium   (Gould and White, 1992) embryonic stage 11 -- 12   somatic mesoderm of embryonic abdominal segment   (Gould and White, 1992) Comment:weakly expressed embryonic stage 11 -- 14   somatic mesoderm   (Gould and White, 1992) foregut primordium   (Gould and White, 1992) longitudinal connective   (Gould and White, 1992) somatic mesoderm of embryonic thoracic segment   (Gould and White, 1992) Comment:strongly expressed embryonic stage 11 -- 17   presumptive embryonic/larval central nervous system | presumptive   (Gould and White, 1992) embryonic stage 12   ventral nerve cord primordium   (Gould and White, 1992) embryonic labial sensory complex | precursor   (Gould and White, 1992) larval maxillary segment sense organ | precursor   (Gould and White, 1992) larval mandibular segment sensillum | precursor   (Gould and White, 1992) embryonic stage 14   embryonic abdominal neuromere | faint   (Gould and White, 1992) embryonic brain   (Gould and White, 1992) embryonic stage 14 -- 16   embryonic thoracic neuromere | intense   (Gould and White, 1992) embryonic stage 16   embryonic/larval brain   (Gould et al., 1990) embryonic thoracic neuromere   (Gould et al., 1990) embryonic abdominal 1 neuromere   (Gould et al., 1990)
Additional Descriptive Data
	Con is expressed on the surface of eight muscles, the motoneurons that innervate them, and several glial cells along the pathways leading to them. Expression is also observed in a subset of CNS neurons and in the visceral mesoderm. (Nose et al., 1992) Con transcripts are first detected at stage 10 in a subset of the cells that will give rise to the visceral mesoderm. There is expression in the presumptive foregut and hindgut mesoderm and in a segmentally repeated subset of the presumptive midgut visceral mesoderm. At late stage 11, transcripts appear in the CNS and in the somatic mesoderm. The initial expression in the somatic mesoderm is strong in the thoracic segments and relatively weak in the abdominal segments. By stage 14, the intensity differences in staining of the somatic mesoderm have subsided by there are differences in the arrangement of staining cells in the thoracic and abdominal segments. In the CNS, the initially uniform staining is succeeded by a more modulated pattern. Differences appear by stage 14 and by stage 16, there is strong staining in the anterior CNS, including the brain lobes and the thoracic neuromeres but little labeling in the abdominal neuromeres. Labelling is also seen in gnathal sense organs. (Gould and White, 1992)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   visceral mesoderm   (Nose et al., 1992) interface glial cell   (Nose et al., 1992) VUM neuron   (Nose et al., 1992) myoblast   (Nose et al., 1992) anterior commissure   (Nose et al., 1992) abdominal 1 lateral transverse muscle 4 -- abdominal 7 lateral transverse muscle 4   (Nose et al., 1992) neuron   • growth cone (Nose et al., 1992) embryonic peripheral glial cell 10   (Nose et al., 1992) abdominal 1 lateral transverse muscle 2 -- abdominal 7 lateral transverse muscle 2   (Nose et al., 1992) abdominal 1 ventral acute muscle 2 -- abdominal 7 ventral acute muscle 2   (Nose et al., 1992) abdominal 1 lateral oblique muscle 1 -- abdominal 7 lateral oblique muscle 1   (Nose et al., 1992) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   embryonic/larval muscle system   (Broadie and Bate, 1993) embryonic stage   posterior commissure   (Nose et al., 1992) motor neuron   (Nose et al., 1992) midline glial cell   (Nose et al., 1992) embryonic peripheral glial cell 4   (Nose et al., 1992) abdominal 1 lateral transverse muscle 3 -- abdominal 7 lateral transverse muscle 3   (Nose et al., 1992) abdominal 1 ventral acute muscle 3   (Nose et al., 1992) longitudinal connective   (Nose et al., 1992) abdominal 1 dorsal transverse muscle 1 -- abdominal 7 dorsal transverse muscle 1   (Nose et al., 1992) abdominal 1 lateral transverse muscle 1 -- abdominal 7 lateral transverse muscle 1   (Nose et al., 1992) peripheral glial cell 4 of SNc   (Nose et al., 1992) muscle founder cell   (Nose et al., 1992) RP1 motor neuron   (Nose et al., 1992) embryonic stage 11   hindgut visceral muscle primordium   (San Martin and Bate, 2001) embryonic stage 13   visceral mesoderm   (Iwaki et al., 2001) adult stage   medulla layer M3   (Takemura et al., 2011)
Additional Descriptive Data
	Con is expressed on the surface of eight muscles, the motoneurons that innervate them, and several glial cells along the pathways leading to them. During synapse formation, Con protein localizes to the synaptic sites and afterwards it largely disappears. Expression is also observed in a subset of neurons and glia in the CNS, in the dorsal cluster of the PNS and in the visceral mesoderm. (Nose et al., 1992) Con protein becomes localized to the neuromuscular junction after innervation. In pros mutants, where innervation fails, expression occurs at the correct developmental stage and localization to a putative neuromuscular junction still occurs. (Broadie and Bate, 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
axonal growth cone inferred from direct assay (Nose et al., 1992) cell surface inferred from direct assay (Nose et al., 1992) neuromuscular junction inferred from direct assay (Broadie and Bate, 1993, Nose et al., 1992)
Expression Deduced from Reporters
Reporter: P{lacZCon.1} Stage Tissue/Position (including subcellular localization) Reference embryonic stage   visceral mesoderm   (Gould and White, 1992) gnathal segment   (Gould and White, 1992) Reporter: P{lacZCon.4} Stage Tissue/Position (including subcellular localization) Reference embryonic stage   gnathal segment   (Gould and White, 1992) somatic mesoderm   (Gould and White, 1992)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain    512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain  512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain    512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain    512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain    512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain  512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain    512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    297.3 Larval Midgut    4.3 Larval Hindgut    3.1 Larval Malpighian Tubules    5 Larval Fat Body    4.9 Larval Salivary Gland    4.1 Larval Trachea    3.775 Larval Carcass    6.45 Adult Head    96.3 Adult Eye    71.725 Adult Brain    512.3 Adult Thoracic-Abdominal Ganglion    333.8 Adult Crop    12.4 Adult Midgut    4.7 Adult Hindgut    10 Adult Malpighian Tubules    5.2 Adult Fat Body    19.5 Adult Salivary Gland    21.2 Adult Heart    6.55 Adult VirginFemale Spermatheca    8.7 Adult InseminatedFemale Spermatheca    13.9 Adult Ovary    2 Adult Testis    2.1 Adult Male Accessory Gland    8.2 Adult Carcass    5.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    96.3   NA  Eye    71.725   NA  Brain    512.3   297.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    333.8   NA  Crop    12.4   4.3  Midgut    4.7   3.1  Hindgut    10   5  Malpighian Tubules    5.2   4.9  Fat Body    19.5   4.1  Salivary Gland    21.2   NA  Heart    6.55   3.775  Trachea    NA   NA  VirginFemale Spermatheca    8.7   NA  InseminatedFemale Spermatheca    13.9   NA  Ovary    2   NA  Testis    2.1   NA  Male Accessory Gland    8.2   6.45  Carcass    5.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    69 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8  (69) head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    69 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    69 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    69 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8  (69) head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    69 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    19 central nervous system, pupae P8    69 head, virgin 1-day female    12 head, virgin 4-day female    10 head, virgin 20-day female    6 head, mated 1-day female    10 head, mated 4-day female    9 head, mated 20-day female    6 head, mated 1-day male    17 head, mated 4-day male    17 head, mated 20-day male    14 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    12 carcass, larvae L3 wandering    3 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed within 06-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    5 embryo 08-10hr    11 embryo 10-12hr    14 embryo 12-14hr    19 embryo 14-16hr    13 embryo 16-18hr    11 embryo 18-20hr    10 embryo 20-22hr    8 embryo 22-24hr    9 larva L1    6 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    5 white prepupae 24hr    8 pupae 2d postWPP    13 pupae 3d postWPP    8 pupae 4d postWPP    2 adult male 01day    3 adult male 05day    2 adult male 30day    2 adult female 01day    1 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    16 ovary OSC    19 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    2 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    3 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    2 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005775 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7503-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable ConFvex236 ConFvex238 ConTl.6.5LR viable, with Scer\GAL4how-24B ConScer\UAS.cRa viable, with Scer\GAL4pnr-MD237 ConGD2312 Sterility Allele female fertile ConTl.6.5LR male fertile ConTl.6.5LR Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4how-24B ConScer\UAS.cRa Phenotype manifest in Allele abdominal 1 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 1 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 1 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 1 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 2 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 2 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 2 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 2 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 2 ventral oblique muscle 6, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 3 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 3 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 3 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 3 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 3 ventral oblique muscle 6, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 4 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 4 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 4 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 4 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 4 ventral oblique muscle 6, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 5 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 5 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 5 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 5 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 5 ventral oblique muscle 6, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 6 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 6 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 6 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 6 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 6 ventral oblique muscle 6, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 7 ventral longitudinal muscle 1, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 7 ventral longitudinal muscle 2, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 7 ventral oblique muscle 4, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 7 ventral oblique muscle 5, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal 7 ventral oblique muscle 6, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal segmental nerve ConTl.6.5LR abdominal segmental nerve, with Scer\GAL4how-24B ConScer\UAS.cRa abdominal segmental nerve | embryonic stage ConFvex238 ConMhc.PN ConTl.6.5LR abdominal ventral muscle | embryonic stage ConMhc.PN RP1 motor neuron ConTl.6.5LR RP3 motor neuron ConTl.6.5LR RP3 motor neuron, with Scer\GAL4how-24B ConScer\UAS.cRa
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Con Class Mutagen Stocks Known lesion ConKG07829 P-element activity 1 -- ConMB00185 1 -- ConMI02118 1 -- ConFvex236 hypomorphic allele - genetic evidence PM hybrid dysgenesis 0 Yes ConFvex238 loss of function allele, hypomorphic allele - genetic evidence PM hybrid dysgenesis 0 Yes ConrF400 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Con Class Mutagen Stocks Known lesion ConGD2312 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ConHM05178 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ConKK107071 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cona.F9.35 in vitro construct 0 Yes ConF9.35 in vitro construct 0 Yes ConMhc.PN in vitro construct - regulatory fusion 0 Yes ConScer\UAS.cCa in vitro construct - regulatory fusion 0 Yes ConScer\UAS.cRa in vitro construct - regulatory fusion 0 Yes ConScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ConTl.6.5LR in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)10H (Nose et al., 1994, Nose et al., 1997) Df(3L)Flex14 (Nose et al., 1994) Df(3L)FX-GJ1 (Nose et al., 1994) Df(3L)FX-OI1 (Nose et al., 1994)
Not disrupted in	Df(3L)X37 (Nose et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{lacZCon.1-35} No P{lacZCon.1} No P{lacZCon.4-35} No P{lacZCon.4} No UAS construct P{GD2312} NA P{KK107071} NA P{TRiP.HM05178} NA P{UAS-Con.C} NA P{UAS-Con.R} NA P{UAS-Con.V5} NA characterization construct P{Mhc'-con} NA P{Toll-connectin} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}ConMI02118 NA P{SUPor-P}ConKG07829 NA insertion of enhancer trap P{PZ}ConrF400 No insertion of enhancer trap binary system Mi{ET1}ConMB00185 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
homophilic cell adhesion inferred from direct assay (Nose et al., 1992)
Cellular Component
CV term Evidence References
axonal growth cone inferred from direct assay (Nose et al., 1992) cell surface inferred from direct assay (Nose et al., 1992) neuromuscular junction inferred from direct assay (Broadie and Bate, 1993, Nose et al., 1992)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axonal fasciculation traceable author statement (Chiba, 1999) cell adhesion non-traceable author statement (FlyBase, 1992-) homophilic cell adhesion non-traceable author statement (Swiss-Prot Project Members, 1993.10.1) traceable author statement (Chiba, 1999) synaptic target attraction traceable author statement (Chiba, 1999)
Cellular Component
CV term Evidence References
plasma membrane traceable author statement (Chiba, 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Con allele Gene References ConFvex238 Sema-1a (Yu et al., 2000) unspecified Fas2 (Yu et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64058 DroID - A comprehensive database of gene and protein interactions. • FBgn0005775 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38590
Orthologs
OrthoDB Orthologs (22) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6C5D47 Dipteran inclusive ortholog search EOG6B5PDN Insect inclusive ortholog search EOG6RBPF1 Arthropod inclusive ortholog search EOG6MCVFQ Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6C5D47)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Con     Drosophila simulans   Dsim\GD13223 Y   Drosophila sechellia   Dsec\GM13940 Y   Drosophila erecta   Dere\GG14154 Y   Drosophila yakuba   Dyak\GE20580 Y   Drosophila ananassae   Dana\GF24709 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28329 Y   Drosophila willistoni   Dwil\GK17589 Y   Drosophila virilis   Dvir\GJ15467 Y   Drosophila mojavensis   Dmoj\GI12564 Y   Drosophila grimshawi   Dgri\GH15784 Y
Orthologs in non-Drosophila Dipterans (EOG6B5PDN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006045   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011234   Anopheles gambiae Malaria mosquito  Agam\AGAP002006   Anopheles gambiae Malaria mosquito  Agam\AGAP002007   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ012649   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015804
Orthologs in non-Dipteran Insects (EOG6RBPF1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Bombyx mori Silkmoth  Bmor\BGIBMGA008576   Bombyx mori Silkmoth  Bmor\BGIBMGA008583   Bombyx mori Silkmoth  Bmor\BGIBMGA008307   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08134
Orthologs in non-Insect Arthropods (EOG6MCVFQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW019298
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13223 Drosophila sechellia Dsec\GM13940 Drosophila erecta Dere\GG14154 Drosophila yakuba Dyak\GE20580 Drosophila ananassae Dana\GF24709 Drosophila pseudoobscura pseudoobscura Dpse\GA28329 Drosophila willistoni Dwil\GK17589 Drosophila virilis Dvir\GJ15467 Drosophila mojavensis Dmoj\GI12564 Drosophila grimshawi Dgri\GH15784
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28967 y1 v1; P{TRiP.HM05178}attP2 35857 y1 w*; Mi{MIC}ConMI02118 22723 y1 w67c23; Mi{ET1}ConMB00185 14662 y1; P{SUPor-P}ConKG07829 ry506
VDRC	v101187 P{KK107071}VIE-260B v17898 w1118; P{GD2312}v17898/CyO
Genomic Clones ( 2 )
	BACR15L14 BACR17L24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 343 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH14524 RE20842 RH30065
Other clones	RT10551
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18414 GM21379 HL02585 HL04943 LD14764 LP10204 RE05714 RE06580 RE11569 RE13128 RE62308 RE70086 RH04324 RH04390 RH07193 RH09243 RH10576 RH10904 RH11852 RH12090 RH13479 RH13709 RH16019 RH16209 RH17093 RH17215 RH17293 RH17409 RH18095 RH18250 RH19751 RH20126 RH20543 RH21653 RH21844 RH22177 RH22556 RH22735 RH26972 RH29568 RH29611 RH29690 RH29717 RH30058 RH30182 RH30333 RH30767 RH31611 RH31616 RH32493 RH32855 RH33778 RH34611 RH35622 RH37622 RH38076 RH39930 RH42014 RH42077 RH42327 RH42543 RH42985 RH44978 RH45176 RH46016 RH46595 RH46639 RH47060 RH47229 RH47315 RH47775 RH48091 RH49746 RH50730 RH51215 RH51705 RH51995 RH52448 RH52603 RH54383 RH54653 RH55168 RH55173 RH55446 RH55941 RH56741 RH56809 RH56819 RH56839 RH56978 RH57786 RH58019 RH58044 RH58239 RH59131 RH60268 RH60713 RH61408 RH61433 RH61478 RH61508 RH61578 RH61691 RH62378 RH63266 RH64377 RH65659 RH66252 RH66273 RH66292 RH66579 RH67049 RH67365 RH67395 RH67957 RH68761 RH68859 RH69793 RH71145 RH73083 RH74330 SD02265 SD09524 SD11290 SD16292 SD16426 SD18363 SD25304
Other clones	14868 31977 39790 40126 43872 100447 176593 190016 214287.16 281660 AI124308 bs24e05 bs46b01 bs46g12 CK01.52A.H11 CK00330 CK01023 CK01042 CK01258 CK01331 CK01336 CK01363 CK01421 CK01448 CK01456 CK01462 CK01603 CK01617 CK01634 CK01718 CK01792 CK01833 CK01958 CK02010 CK02026 CK02083 CK02089 CK02102 CK02134 CK02139 CK02216 CK02225 CK02311 CK02315 CK02322 CK02323 CK02429 CK02564 CK02584 CK02648 EC41454 EC053663 EC055739 EK027108 EK030002 EK031312 EK032025 EK034826 EK040028 EK042132 EK043120 EK047843 EK048304 EK049563 EK050409 EK053809 EK058252 EK058646 EK059016 EK063402 EK066025 EK072843 EK073259 EK074745 EK075111 EK077604 EK082259 EK085812 EK087859 EK089024 EK089958 EK092228 EK095603 EK104936 EK105342 EK107809 EK108409 EK113540 EK115509 EK116527 EK117157 EK117228 EK117938 EK119258 EK121312 EK129929 EK130147 EK133510 EK139758 EK142635 EK145429 EK147049 EK150160 EK150812 EK153913 EK154064 EK159214 EK160129 EK161453 EK163151 EK165022 EK165624 EK165964 EK178057 EK178259 EK182949 EK183856 EK183952 EK184711 EK187045 EK194453 EK194822 EK197709 EK198161 EK198534 EK201106 EK203155 EK205033 EK206320 EK206804 EK207149 EK209011 EK215732 EK217506 EK219351 EK221844 EK223437 EK225650 EK225919 EK227244 EK227895 EK228028 EK240954 EK241147 EK243327 EK243447 EK246762 EK253707 EK258226 EK261906 EK264714 EK265613 EK267119 EK267342 EK267760 EK278350 EK278462 EK281347 EK289455 EK289458 EK290364 EK290945 EK291554 EK292041 EK296753 EK298836 EK301716 EK303642 EK304364 EK306751 EN01164 EN02064 EN15045 EN17428 EP00315 EP01012 EP02228 EP02341 EP04728 EP04754 EP05547 EP07649 EP08720 EP08834 EP08943 EP09905 EP10203 EP10234 EP10464 EP10540 EP11254 EP11446 EP11516 EP11550 EP11622 EP11914 EP13133 EP13602 EP14842 EP16650 EP17315 EP17909 EP18944 EP19157 EP19847 EP21045 FGM236G12 GH07201 GH07423 GH12337 RH24219
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0005775 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38590
Antibody Information
	polyclonal (Nose et al., 1992)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Ectopic expression of Con in all muscles causes SNa motorneurons to often inappropriately innervate a neighbouring non-target muscle that ectopically expresses Con. The ectopic synapse formation is dependent on the endogenous Con expression on the SNa motoneurons. Results show that Con can function as an attractive and homophilic target recognition molecule in vivo. Con has a specific function during SNb pathfinding. (Nose et al., 1997) The pattern of expression of Con protein during embryogenesis has been analysed. (Meadows et al., 1994) Con functions as a repulsive signal for SNb growth cones in vivo, Con has a specific and robust repulsive function during motoneuron growth cone guidance and synapse formation. (Nose et al., 1994) In pros mutants, where innervation of muscles fails, connectin is expressed on muscle surface begins in same developmental pattern as in wild type. (Broadie and Bate, 1993) Con gene product plays a role in neuromuscular connectivity. (Nose et al., 1993) A chromatin immunopurification approach isolated the Connectin gene as a binding site for Ubx in vivo. The product is predicted to be a cell surface molecule containing leucine rich repeats and can mediate cell-cell adhesion. (Gould and White, 1992) Con is a novel cell adhesion molecule whose expression suggests a role in target recognition. (Nose et al., 1992) The genes encoding the 35 and 48 transcripts, Con and T48 respectively, are good candidates for the target genes directly regulated by the homeotic gene Ubx. (Gould et al., 1990) Cloned as a potential Ubx target gene.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079206 NM_001259706 RefSeq (Proteins) • NP_523930 NP_001246635 DDBJ / EMBL / GenBank • AAA28424 AAF47952 AAM50172 AFH04306 AI238476 AW940556 AY119518 BH900960 BI214728 CAA48652 M96647 X68701 Entrez Gene - A searchable database of RefSeq genes. • 38590 UniProtKB/Swiss-Prot • Q01819
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cysteine-rich flanking region, C-terminal (IPR000483) Leucine-rich repeat, typical subtype (IPR003591) Leucine-rich repeat (IPR001611)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64058 DroID - A comprehensive database of gene and protein interactions. • FBgn0005775 DRSC - Results from RNAi screens. • FBgn0005775 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0005775 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7503-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0005775 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38590 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/conectn1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38590 modMine - Data generated by the modENCODE project. • FBgn0005775 REDfly - A database of transcriptional regulatory elements. • FBgn0005775
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-64C   CG7503 (Keleman et al., 2009.8.5, Perkins et al., 2009) CON (Hosono et al., 2003) con (Solano et al., 2003, Bilder and Scott, 1998) Con (de Velasco et al., 2006, Jakobsen et al., 2007, Zhai et al., 2012, Hueber et al., 2007, Carrasco-Rando et al., 2011, Magalhaes et al., 2007, Okumura et al., 2010, Hozumi et al., 2008) conn (Yu et al., 2000, Fambrough and Goodman, 1996) CT1840 (Hynes and Zhao, 2000) Ubx-t35
Name Synonym	connectin (Bour et al., 1998, Wilson, 1993, Meadows et al., 1994, Gould and White, 1992, Pearson et al., 2005, Yan et al., 2010) Connectin (de Velasco et al., 2006, Takemura et al., 2011, Carrasco-Rando and Ruiz-Gómez, 2008, Andrews et al., 2008, Yan et al., 2009, Reed et al., 2010, Okumura et al., 2010, Hozumi et al., 2008) transcript-35
Secondary FlyBase IDs
	FBgn0004358
References ( 123 )
Generate a list of	All references relating to this gene ( 123 )
List References by type	Research paper  ( 64 ) Supplementary material  ( 3 ) Review  ( 31 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 10 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Zhai et al., 2012, PLoS Genet. 8(3): e1002582 Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859] Carrasco-Rando et al., 2011, PLoS Genet. 7(7): e1002186 Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate. [FBrf0214635] Takemura et al., 2011, Curr. Biol. 21(24): 2077--2084 Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. [FBrf0217052] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...