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Gene Dmel\hbn

General Information
Symbol	Dmel\hbn	Species	D. melanogaster
Name	homeobrain	Annotation symbol	CG33152
Feature type	protein_coding_gene	FlyBase ID	FBgn0008636
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	CG10614
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	57B5-57B5	Sequence location	2R:16,842,169..16,848,414 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene homeobrain is referred to in FlyBase by the symbol Dmel\hbn (CG33152, FBgn0008636). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: regulation of transcription, DNA-dependent. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox; Homeobox, conserved site; Homeodomain-like; Homeodomain-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. Comments on Affy2 ProbeSet: ProbeSet 1640180_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hbn. Gene sequence location is 2R:16842169..16848414.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA04239 BKN45115 HFA04082 BKN23815 HFA04238
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 57B5-57B5   Limits computationally determined from genome sequence between P{lacW}l(2)k06409k06409&P{PZ}insc05475 and P{PZ}l(2)0780607806
Experimentally Determined Cytological Location
Cytogenetic map Notes References 57B-57B     (Walldorf, 2000.3.20) 57B1-57B5   (determined by in situ hybridisation)   (Dessain and McGinnis, 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hbn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hbn-RA FBtr0071556  NM_176240   1802   409
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hbn-PA   FBpp0071485   44.7   409   8.16     NP_788420   AAF46642
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF46642   AJ276705 CAC06429   BT022158   BX007026   BX012749   BX014411   BX026032   BX029574   BX030199   BX031757   BX034036   BX034515   BX034689   BX043105   BX050018   BX056210   BX067176
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9GRX3 Q9W2P8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 14   embryonic head | dorso-lateral & restricted   (Walldorf et al., 2000) Comment:complex dynamic pattern embryonic stage 11 -- 13   ventral nerve cord primordium | restricted & segmentally repeated   (Walldorf et al., 2000) Comment:a few cells per neuromere embryonic stage 13 -- 15   embryonic hindgut | anterior & faint & restricted   (Walldorf et al., 2000) embryonic stage 14 -- 17   embryonic/larval brain | restricted   (Walldorf et al., 2000) Comment:discrete localized domains of expression ventral nerve cord | restricted   (Walldorf et al., 2000) Comment:discrete localized domains of expression
Additional Descriptive Data
	hbn transcript expression begins at embryonic stage 4 as a U-shaped pattern in the dorsal head region. During embryonic stage 5 the hbn expression domain retracts from the ventro-lateral side of the presumptive head. A second hbn expression domain, dorso-lateral to the first domain, becomes visible on each side of the embryo during embryonic stages 6-7, and the U-shaped pattern resolves into two distinct domains, a weakly-expressed dorsal domain and a strongly-expressed dorso-lateral domain. During embryonic stages 9-10, transcript expression is detected in three domains on each side of the dorsal posterior head and in a dorsal-anterior spot. When the germband is fully extended at stage 11, a few cells in each neuromere of the ventral nerve cord express hbn transcript. Shortly afterwards each of the three dorso-lateral expression domains in the head split, resulting in six dorso-lateral patches of expression. hbn transcript is expressed in the developing hindgut at the boundary with the midgut during germband retraction. Discrete localized expression domains in the brain and in the ventral nerve cord are detected until the end of embryogenesis. (Walldorf et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0008636    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0008636 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0008636 expression level Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr  (959) embryo 04-06hr  (661) embryo 06-08hr  (328) embryo 08-10hr  (266) embryo 10-12hr  (192) embryo 12-14hr  (181) embryo 14-16hr  (155) embryo 16-18hr  (123) embryo 18-20hr  (136) embryo 20-22hr    95 embryo 22-24hr  (108) larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6  (109) larva L3 puffstage 7-9  (144) white prepupae new  (157) white prepupae 12hr  (269) white prepupae 24hr  (254) pupae 2d postWPP  (160) pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0008636 expression level Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr  (959) embryo 04-06hr  (661) embryo 06-08hr  (328) embryo 08-10hr  (266) embryo 10-12hr  (192) embryo 12-14hr  (181) embryo 14-16hr  (155) embryo 16-18hr  123 embryo 18-20hr  136 embryo 20-22hr    95 embryo 22-24hr  108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6  109 larva L3 puffstage 7-9  (144) white prepupae new  (157) white prepupae 12hr  (269) white prepupae 24hr  (254) pupae 2d postWPP  (160) pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    59 embryo 02-04hr    959 embryo 04-06hr    661 embryo 06-08hr    328 embryo 08-10hr    266 embryo 10-12hr    192 embryo 12-14hr    181 embryo 14-16hr    155 embryo 16-18hr    123 embryo 18-20hr    136 embryo 20-22hr    95 embryo 22-24hr    108 larva L1    81 larva L2    24 larva L3 12hr old    27 larva L3 puffstage 1-2    61 larva L3 puffstage 3-6    109 larva L3 puffstage 7-9    144 white prepupae new    157 white prepupae 12hr    269 white prepupae 24hr    254 pupae 2d postWPP    160 pupae 3d postWPP    74 pupae 4d postWPP    80 adult male 01day    65 adult male 05day    66 adult male 30day    77 adult female 01day    37 adult female 05day    10 adult female 30day    11 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0008636    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0008636 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0008636 expression level Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0008636 expression level Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    81.025 Larval Midgut    5.9 Larval Hindgut    1.9 Larval Malpighian Tubules    4.4 Larval Fat Body    3.2 Larval Salivary Gland    5.5 Larval Trachea    1.1 Larval Carcass    2.15 Adult Head    25.7 Adult Eye    7.375 Adult Brain    121.8 Adult Thoracic-Abdominal Ganglion    2.9 Adult Crop    3 Adult Midgut    8.8 Adult Hindgut    5.3 Adult Malpighian Tubules    3.2 Adult Fat Body    2.1 Adult Salivary Gland    1.2 Adult Heart    0.425 Adult VirginFemale Spermatheca    1.7 Adult InseminatedFemale Spermatheca    3 Adult Ovary    3.1 Adult Testis    1.4 Adult Male Accessory Gland    1.7 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    25.7   NA  Eye    7.375   NA  Brain    121.8   81.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.9   NA  Crop    3   5.9  Midgut    8.8   1.9  Hindgut    5.3   4.4  Malpighian Tubules    3.2   3.2  Fat Body    2.1   5.5  Salivary Gland    1.2   NA  Heart    0.425   1.1  Trachea    NA   NA  VirginFemale Spermatheca    1.7   NA  InseminatedFemale Spermatheca    3   NA  Ovary    3.1   NA  Testis    1.4   NA  Male Accessory Gland    1.7   2.15  Carcass    5.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0008636 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33152-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage hbn4028 hbn15227 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of hbn Class Mutagen Stocks Known lesion hbnMB04955 1 -- hbn15227 ethyl methanesulfonate 0 Yes hbn4028 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hbn Class Mutagen Stocks Known lesion hbnJF02195 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hbnKK103623 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hbnGD4352 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6071 (Ryder, 2004.4.26) Df(2R)Exel7166 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4352} NA P{KK103623} NA P{TRiP.JF02195} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG02514 NA insertion of enhancer trap binary system Mi{ET1}hbnMB04955 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-) non-traceable author statement (Walldorf, 2000.3.20)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with InterPro:IPR001356 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hbn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71041 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0008636 DroID - A comprehensive database of gene and protein interactions. • FBgn0008636 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47894
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12736 Dere\GG20821 Dgri\GH19875 Dmoj\GI19825 Dper\GL17416 Dpse\GA17327 Dsec\GM15768 Dsim\GD25243 Dvir\GJ18584 Dwil\GK22873 Dyak\GE13762
Curated drosophilid orthologs	Dpse\GA17327
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001696-PA Aedes aegypti (mosquito) AGAP005311-PA Anopheles gambiae (mosquito) ENSBTAP00000025512 Bos taurus (bovine) CN17592 Caenorhabditis brenneri (small nematode) ENSCINP00000023913 Ciona intestinalis (sea squirt) CPIJ015160 Culex pipens (mosquito) ENSECAP00000014068 Equus caballus (horse) ENSGALP00000036659 Gallus gallus (chicken) 160291 Lottia gigantea (owl limpet) ENSMODP00000009803 Monodelphis domestica (gray opossum) ENSMUSP00000012664 Mus musculus (house mouse) XP_001606592.1 Nasonia vitripennis (wasp) ENSORLP00000024886 Oryzias latipes (japanese killifish) ENSPPYP00000016415 Pongo pygmaeus (orangutan) ENSRNOP00000003136 Rattus norvegicus (norway rat) YALI0F16852g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21238 LH14720 FBgn0231415 FBgn0224835 FBgn0205742 FBgn0196555 FBgn0170684 FBgn0077340 FBgn0155019 FBgn0142562 FBgn0127339 FBgn0113007 FBgn0089770 CPIJ015160 BGIBMGA000211 ACYPI45707 GB13412 AGAP005311 AAEL001696 PB21871 GLEAN_08926
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	24311 w1118; Mi{ET1}hbnMB04955 31906 y1 v1; P{TRiP.JF02195}attP2/TM3, Sb1
VDRC	v103979 P{KK103623}VIE-260B
Genomic Clones ( 3 )
	BACR04E05 BACR10P11 BACR10P16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP01393
Other clones	DPiM_IP01393
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0008636 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47894
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: homeobrain CG10614 CG15647 (FlyBase, 1996-)
Source for database merge of
Additional comments	Annotations CG10614, CG15647, CG15648 merged as CG33152 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for identity of homeobrain CG10614 CG15647 was sequence comparison (date:000915). (FlyBase, 1996-)
Other Comments
	hbn is required for os-induced Stat92E phosphorylation. (Baeg et al., 2005) S2-derived S2-NP cells are treated with dsRNA made from templates generated with primers directed against hbn to assess the role of this gene in Stat92E tyrosine phosphorylation. (Baeg et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) 57B is one of several locations where pairs of distinct homeodomains, in this case hbn and Rx, are found. The hbn homeodomain is closely related to the otp homeodomain. (Dessain and McGinnis, 1993) An incompletely characterised homeodomain sequence.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_176240 RefSeq (Proteins) • NP_788420 DDBJ / EMBL / GenBank • AAF46642 AJ276705 CAC06429 Entrez Gene - A searchable database of RefSeq genes. • 47894 UniProtKB/TrEMBL • Q9GRX3 Q9W2P8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeobox (IPR001356) Homeodomain-like (IPR009057) Homeodomain-related (IPR012287)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71041 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0008636 DroID - A comprehensive database of gene and protein interactions. • FBgn0008636 DRSC - Results from RNAi screens. • FBgn0008636 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0008636 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33152-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0008636 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 47894 InParanoid A subset of ortholog calls from InParanoid. • AAEL001696-PA Aedes aegypti (mosquito) AGAP005311-PA Anopheles gambiae (mosquito) ENSBTAP00000025512 Bos taurus (bovine) CN17592 Caenorhabditis brenneri (small nematode) ENSCINP00000023913 Ciona intestinalis (sea squirt) CPIJ015160 Culex pipens (mosquito) ENSECAP00000014068 Equus caballus (horse) ENSGALP00000036659 Gallus gallus (chicken) 160291 Lottia gigantea (owl limpet) ENSMODP00000009803 Monodelphis domestica (gray opossum) ENSMUSP00000012664 Mus musculus (house mouse) XP_001606592.1 Nasonia vitripennis (wasp) ENSORLP00000024886 Oryzias latipes (japanese killifish) ENSPPYP00000016415 Pongo pygmaeus (orangutan) ENSRNOP00000003136 Rattus norvegicus (norway rat) YALI0F16852g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 47894 modMine - Data generated by the modENCODE project. • FBgn0008636 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV21238 LH14720 FBgn0231415 FBgn0224835 FBgn0205742 FBgn0196555 FBgn0170684 FBgn0077340 FBgn0155019 FBgn0142562 FBgn0127339 FBgn0113007 FBgn0089770 CPIJ015160 BGIBMGA000211 ACYPI45707 GB13412 AGAP005311 AAEL001696 PB21871 GLEAN_08926
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	57San   CG10614 (Boutros et al., 2004, Popovici et al., 2001, ) CG15647   CG15648   CG33152 (Keleman et al., 2009.8.5, Perkins et al., 2009) hbn (Hoskins et al., 2005, Liebl and Featherstone, 2005, Hazelett et al., 2009)
Name Synonym	homeobrain (Walldorf et al., 2000, Carpenter et al., 2009) Homeobrain (Davis et al., 2005)
Secondary FlyBase IDs
	FBgn0034561 FBgn0034562 FBgn0040654 FBgn0053152
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
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Recent reviews (0)
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