FlyBase Gene Report: Dmel\lbl

General Information

Symbol

Dmel\lbl

Species

D. melanogaster

Name

ladybird late

Annotation Symbol

CG6570

Feature Type

protein_coding_gene

FlyBase ID

FBgn0008651

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

ladybird late (lbl) encodes a transcription factor involved in muscle and heart development. It also plays a role in regulating the embryonic expression of wg. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

lb, ladybird

Key Links

Genomic Location

Cytogenetic map

93E1-93E1

Sequence location

3R:21,409,979..21,434,133 [-]

Recombination map

3-72

RefSeq locus

NT_033777 REGION:21409979..21434133

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002388800

(assigned by GO_Central )

(Gaudet et al., 2011)

enables sequence-specific double-stranded DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002388800

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (8 terms)

CV Term

Evidence

References

involved_in cell migration

inferred from genetic interaction with FLYBASE:lbe; FB:FBgn0011278

(Junion et al., 2007)

involved_in epidermis development

inferred from mutant phenotype

(Jagla et al., 1997)

involved_in genital disc morphogenesis

inferred from mutant phenotype

(Jagla et al., 1997)

involved_in imaginal disc-derived leg morphogenesis

inferred from genetic interaction with FLYBASE:lbe; FB:FBgn0011278

(Maqbool et al., 2006)

involved_in myoblast proliferation

inferred from genetic interaction with FLYBASE:lbe; FB:FBgn0011278

(Maqbool et al., 2006)

involved_in regulation of cell fate specification

inferred from mutant phenotype

(Jagla et al., 2002)

involved_in regulation of neuron differentiation

inferred from mutant phenotype

(De Graeve et al., 2004)

involved_in regulation of transcription, DNA-templated

inferred from mutant phenotype

(Jagla et al., 1997)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN002388800

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Jagla et al., 1997)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002388800

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

ladybird late (lbl) encodes a transcription factor involved in muscle and heart development. It also plays a role in regulating the embryonic expression of wg. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS -: NK-like (NKL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. NKL transcription factors are homeobox genes closely related to Hox-like genes, a number of which are found in the NK cluster. Many of the NKL members contain an Engrailed Homology 1 (EH1) motif. (Adapted from FBrf0232555 and PMID:22094586).

Summary (Interactive Fly)

transcription factors - homeodomain proteins -overlaps expression of in the epidermis - genes contribute to the segmentation process and are considered as segment polarity genes

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\lbl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.45

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

lbl-RA

FBtr0084092

NM_079710

1855

372

lbl-RB

FBtr0300061

NM_001144620

1758

294

lbl-RC

FBtr0332438

NM_001275876

1803

410

Additional Transcript Data and Comments

Reported size (kB)

2.0 (northern blot)

(Jagla et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

lbl-PA

FBpp0083491

41.7

372

10.26

NP_524434

AAF55895

lbl-PB

FBpp0289338

32.5

294

8.83

NP_001138092

ACL83548

lbl-PC

FBpp0304711

46.8

410

9.54

NP_001262805

AGB96185

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lbl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lbl_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 10 -- 13

dorsal ectoderm of abdominal segment 1 -- abdominal segment 7

(Jagla et al., 1997)

embryonic stage 11

muscle founder cell

(Philippakis et al., 2006)

embryonic stage 11 -- 12

anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

labral sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

embryonic stage 11 -- 17

anal pad

(Jagla et al., 1997)

embryonic stage 13

epidermis | segmentally repeated

(Jagla et al., 1994)

ectoderm | ventral

(Jagla et al., 1997)

segment border muscle cell

(Jagla et al., 1997)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 15

epidermis | dorsal

Comment: early embryonic stage 15

(Jagla et al., 1997)

late embryonic stage

embryonic/larval peripheral nervous system | restricted

(Jagla et al., 1997)

embryonic/larval central nervous system | restricted

(Jagla et al., 1997)

pcr

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 17

Comment: reference states 8-20 hr AEL

(Jagla et al., 1993)

embryonic stage 13 -- 17

presumptive embryonic/larval central nervous system | restricted

(Jagla et al., 1993)

larval ventral nerve cord

(Jagla et al., 1993)

third instar larval stage

(Jagla et al., 1993)

pupal stage

(Jagla et al., 1993)

Additional Descriptive Data

lbe transcript appears earlier, and is more abundant, than the lbl transcript. Both transcripts are expressed in the anal plate primordium, with lbl expression starting at stage 10-11. At stage 10-11, expression is also detected in a cluster of cells corresponding to the heart primordium. During embryonic stages 10-13, lbe and lbl are both expressed in the dorsal ectoderm of abdominal segments 1-7, and to a lesser extent, in the ventral ectoderm. At stage 15, lbl and lbe transcripts persist in the dorsal, but not in the ven ral, epidermis. Later in embryogenesis, lbl and lbe transcripts are restricted to clusters of cells in the central and peripheral nervous systems, and to the segment border muscles.

(Jagla et al., 1997)

Using RT-PCR, lbl transcript is detected in embryogenesis 2 hours after lbe, and persists through embryogenesis. lbl transcript is detected in stage 13 embryos, in the dorsal and ventral epidermis in a segmentally repeated pattern.

(Jagla et al., 1994)

Using RT-PCR, lbl transcript is detected in 8-20 hr embryos, in third instar larvae, and in pupae. In-situ hybridization to stage 13-17 embryos reveals that lbl is expressed in parts of the developing central nervous system, including cells of the ventral nerve cord. Strongest expression is seen during early ventral cord condensation.

(Jagla et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 10 -- 13

dorsal ectoderm of abdominal segment 1 -- abdominal segment 7

(Jagla et al., 1997)

embryonic stage 11 -- 17

anal pad

(Jagla et al., 1997)

embryonic stage 13

ectoderm | ventral

(Jagla et al., 1997)

segment border muscle cell

(Jagla et al., 1997)

embryonic stage 15

epidermis | dorsal

Comment: early embryonic stage 15

(Jagla et al., 1997)

late embryonic stage

embryonic/larval central nervous system | restricted

(Jagla et al., 1997)

embryonic/larval peripheral nervous system | restricted

(Jagla et al., 1997)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Jagla et al., 1997)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\lbl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lbl

View exonic expression by tissue for Dmel\lbl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0008651

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42541/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0008651

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0008651

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0008651

Flygut - An atlas of the Drosophila adult midgut

FBgn0008651

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lbl

Transgenic constructs containing regulatory region of lbl

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene partially disrupted in

Df(3R)e-F1

(De Graeve et al., 2004)

Df(3R)lb

(De Graeve et al., 2004)

Gene disrupted in

Df(3R)e-BS2

(Jagla et al., 1997)

Df(3R)e-F1

(Jagla et al., 1997)

Gene not disrupted in

Df(3R)e-Gp4

(Jagla et al., 1997)

Df(3R)GC14

(Jagla et al., 1997)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

lbl^f02857

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

lbl^GD17297

viable, with Scer\GAL4^Mef2.PR

lbl^GD4156

viable, with Scer\GAL4^pnr-MD237

lbl^GD4156

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

fertile

lbl^f02857

Phenotype manifest in

Allele

central nervous system, with Scer\GAL4^{l(3)31-1-31-1}

lbl^UAS.cJa

dorsal denticle

lbl^hs.PJ

EL neuron, with Scer\GAL4^{l(3)31-1-31-1}

lbl^UAS.cJa

embryonic/larval dorsal vessel | precursor

lbl^hs.PJ

exit glial cell | ectopic, with Scer\GAL4^{l(3)31-1-31-1}

lbl^UAS.cJa

glial cell | ectopic, with Scer\GAL4^{l(3)31-1-31-1}

lbl^UAS.cJa

larval intersegmental nerve, with Scer\GAL4^{l(3)31-1-31-1}

lbl^UAS.cJa

larval prothoracic segmental nerve, with Scer\GAL4^{l(3)31-1-31-1}

lbl^UAS.cJa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (26)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\LBX1

9 of 15

Yes

7 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (20)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Lbx1

9 of 15

Yes

Mmus\Lbx2

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Mmus\Tlx1

1 of 15

Mmus\Tlx2

1 of 15

Mmus\Tlx3

1 of 15

Rattus norvegicus (Norway rat) (19)

Rnor\Lbx1

8 of 13

Yes

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\lbx1

4 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (21)

Drer\lbx1a

9 of 15

Yes

8 of 15

7 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\vent

1 of 15

Yes

Drer\vox

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\ceh-1

1 of 15

Yes

Cele\ceh-19

1 of 15

Yes

Cele\ceh-30

1 of 15

Yes

Cele\ceh-31

1 of 15

Yes

Cele\lim-7

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (12)

Atha\HAT1

2 of 9

Yes

Atha\HAT14

2 of 9

Yes

Atha\HAT22

2 of 9

Yes

Atha\HB4

2 of 9

Yes

Atha\HB17

2 of 9

Yes

Atha\HB18

2 of 9

Yes

Atha\HAT2

1 of 9

Yes

Atha\HAT3

1 of 9

Yes

Atha\HAT9

1 of 9

Yes

Atha\HB-2

1 of 9

Atha\HB-3

1 of 9

Atha\HB-7

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\YHP1

1 of 15

Yes

Scer\YOX1

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BX4 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00010356

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila simulans

Drosophila sechellia

Drosophila sechellia

Drosophila erecta

Drosophila erecta

Drosophila yakuba

Drosophila yakuba

Drosophila yakuba

Drosophila ananassae

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA19692

Drosophila pseudoobscura pseudoobscura

Dpse\GA19675

Drosophila persimilis

Dper\GL24421

Drosophila persimilis

Dper\GL24419

Drosophila willistoni

Dwil\GK11029

Drosophila willistoni

Dwil\GK11027

Drosophila virilis

Dvir\GJ14417

Drosophila virilis

Dvir\GJ14418

Drosophila mojavensis

Dmoj\GI10818

Drosophila mojavensis

Dmoj\GI10819

Drosophila grimshawi

Dgri\GH18718

Drosophila grimshawi

Dgri\GH18729

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915066Z )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17018447

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12847

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0K1C )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005257

Ixodes scapularis

Black-legged tick

Isca\ISCW021484

Stegodyphus mimosarum

African social velvet spider

Smim\KFM69388.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur02g09640

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_44455

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09CY )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Lbx

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (9)

Gene Symbol

Score

Source

Alignment

lbe

7 of 10

B-H1

1 of 10

B-H2

1 of 10

C15

1 of 10

CG11085

1 of 10

CG34031

1 of 10

Dbx

1 of 10

H2.0

1 of 10

slou

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LBX1; ladybird homeobox 1

9 of 15

604255

CENTRAL HYPOVENTILATION SYNDROME, CONGENITAL, 3; CCHS3

LBX2; ladybird homeobox 2

7 of 15

607164

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

lbl - B52

systematic evolution of ligands by exponential enrichment, full identification by DNA sequencing, electrophoretic mobility shift assay, autoradiography

(Kim et al., 2003)

protein-protein

Physical Interaction

Assay

References

lbl - CG10887

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

67507

DroID - A comprehensive database of gene and protein interactions.

FBgn0008651

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-72

Cytogenetic map

93E1-93E1

Sequence location

3R:21,409,979..21,434,133 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

93E1-93E1

Limits computationally determined from genome sequence between P{PZ}mod(mdg4)⁰⁷⁰³⁸&P{lacW}mod(mdg4)^L3101 and P{PZ}InR⁰⁵⁵⁴⁵

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

93E1-93E1

(Jagla, 1996.10.14)

93D-93E

(determined by in situ hybridisation)

(Jagla et al., 1994)

93D9-93E2

(determined by in situ hybridisation)

(Ranz et al., 1997, Jagla et al., 1993)

Experimentally Determined Recombination Data

Location

3-72

(FlyBase, 2016)

3-74.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Bloomington

18594

w¹¹¹⁸; PBac{WH}lbl^f02857

26458

w¹¹¹⁸; Mi{ET1}lbl^MB09264

79860

y¹ sc^* v¹ sev²¹; P{TOE.GS02054}attP40

35698

y¹ sc^* v¹ sev²¹; P{TRiP.GLV21063}attP2

60001

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04993}attP40

VDRC

v103231

P{KK112588}VIE-260B

v52323

w¹¹¹⁸; P{GD17297}v52323

v341887

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01100}attP40/CyO-GFP

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP08853

Other clones

DPiM_IP08853

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0008651

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0008651

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42541

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jagla et al., 1997)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

The previously unrecognised eh-1-domain interacting with gro may provide the basis for the lbl-mediated repression of target genes, such as eve in the embryonic mesoderm.

(Giot et al., 2003)

Cross-repressive interactions between the "identity genes" lbe, lbl, Dr and eve are essential for the specification of cardiac and muscular fates in the developing embryo.

(Jagla et al., 2002)

The specific epidermal expression patterns of lbe and lbl and their regulatory interactions with wg are analysed. Activity of lbe and lbl in the epidermis is regulated by the segment polarity gene network and depends on wg signalling. lbe and lbl are required in the dorsal epidermis and for anal plate development.

(Jagla et al., 1997)

lbe and lbl are involved in the specification of a segmental subset of heart precursors during the early phase of cardiogenesis, and are required for maintaining wg activity during the late phase of cardiogenesis.

(Jagla et al., 1997)

Cloning and characterisation of homeobox genes lbe and lbl.

(Jagla et al., 1994)

lbl belongs to the group of homeobox genes which contain an intron between codons for homeo-domain amino acids 44 and 45. Transcripts are detected in the CNS during late stages of embryogenesis.

(Jagla et al., 1993)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 42 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42541

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0008651

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0008651

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42541/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0008651

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lbl_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0008651

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0008651

Flygut - An atlas of the Drosophila adult midgut

FBgn0008651

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

42541

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG6570

MARRVEL_MODEL - MARRVEL (model organism gene)

42541

modMine - A data warehouse for the modENCODE project

FBgn0008651

Linkouts

BioGRID - A database of protein and genetic interactions.

67507

DroID - A comprehensive database of gene and protein interactions.

FBgn0008651

DRSC - Results frm RNAi screens

FBgn0008651

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0008651

FlyMine - An integrated database for Drosophila genomics

FBgn0008651

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG6570

(Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Perkins et al., 2009, Klebes et al., 2005)

(Zmojdzian and Jagla, 2021, Poovathumkadavil and Jagla, 2020, Schaub et al., 2012, Carrasco-Rando et al., 2011, Figeac et al., 2010, Bataillé et al., 2007, Monier et al., 2007, Lo and Frasch, 2003, Zaffran and Frasch, 2000)

Lbl

(Figeac et al., 2010, Nguyen and Frasch, 2006)

NK?

NKch4

(Dubey et al., 2020, Figeac et al., 2010, Klingseisen et al., 2009, Junion et al., 2007, De Graeve et al., 2004, Reim et al., 2003, Zikova et al., 2003, Cripps and Olson, 2002, Frasch, 1999, Knirr et al., 1999, Paululat et al., 1999, Ruiz-Gomez, 1998)

nkch4

(Jagla et al., 1993)

Name Synonyms

Ladybird

(Carrasco-Rando et al., 2011, Clark et al., 2006, Chen and Olson, 2004, Lo and Frasch, 2003, Dworak and Sink, 2002)

NK-cluster homeobox 4

(Jagla et al., 1993)

lady-bird-late

(Jagla et al., 1994)

ladybird

(Figeac et al., 2010, Bataillé et al., 2007, Junion et al., 2007, Clark et al., 2005, Urbach and Technau, 2002, Bidet et al., 2001, Hughes and Salinas, 1999, Baylies et al., 1998, Nguyen and Xu, 1998, Tajbakhsh and Sporle, 1998, Ruiz Gomez and Bate, 1997)

ladybird late

(Chang et al., 2008, Junion et al., 2007, Maqbool et al., 2006, Philippakis et al., 2006, Jagla et al., 1997)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (114)

Report Sections

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