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Gene Dmel\Canp
| General Information | ||||||||
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| Symbol | Dmel\Canp | Species | D. melanogaster | |||||
| Name | Ca2+-activated neutral protease | Annotation symbol | ||||||
| Feature type | gene | FlyBase ID | FBgn0010013 | |||||
| Gene Model Status | Unannotated | Stock availability | None publicly available | |||||
| Genomic Location | ||||||||
| Chromosome (arm) | Recombination map | |||||||
| Cytogenetic map | Sequence location | |||||||
 Summary Information | ||||||||
| Automatically generated summary
See sections below for more information | The gene Ca2+-activated neutral protease is referred to in FlyBase by the symbol Dmel\Canp (FBgn0010013). It is a gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: calcium-dependent cysteine-type endopeptidase activity. The biological processes in which it is involved are not known. No alleles are reported. It has no annotated transcripts. Gene has not been localized to the genome sequence. | |||||||
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Recent Updates
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| Description |
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| FB2012_01 | ||||||||
| FB2011_10 | ||||||||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | |||||||
| Detailed Mapping Data | ||||||||
| FlyBase Computed Cytological Location | ||||||||
Cytogenetic map Evidence for location | ||||||||
| Experimentally Determined Cytological Location | ||||||||
Cytogenetic map Notes References | ||||||||
| Experimentally Determined Recombination Data | ||||||||
| Location | ||||||||
| Left of (cM) | ||||||||
| Right of (cM) | ||||||||
| Notes | ||||||||
| Gene Model & Products | ||||||||
| Comments on Gene Model | ||||||||
| Transcript Data | ||||||||
| Annotated Transcripts | ||||||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS
(aa) | ||||||||
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| Reported size (kB) | ||||||||
| Comments | ||||||||
| External Data | ||||||||
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Polypeptide Data | ||||||||
| Annotated Polypeptides | ||||||||
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein | ||||||||
| Additional Polypeptide Data & Comments | ||||||||
| Reported size (kDa) | 94 (kD) | |||||||
| Comments | Canp enzyme was isolated from Drosophila adults. The enzyme is absolutely Ca2+-dependent and shows the inhibitor pattern of thiol proteases. Several of its properties resemble those of vertebrate calpain II, however no analog of the vertebrate calpain II small subunit was found. | |||||||
| External Data | ||||||||
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| Crossreferences | ||||||||
| Sequences Consistent with the Gene Model
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| DDBJ / EMBL / GenBank | DNA sequence Protein
sequence Name | |||||||
| UniProtKB/Swiss-Prot | ||||||||
| UniProtKB/TrEMBL | ||||||||
| Mapped Features | ||||||||
Type Symbol &
Location Additional Notes References | ||||||||
| External Data | ||||||||
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| Crossreferences | ||||||||
| Expression Data | ||||||||
| Transcript Expression | ||||||||
| Additional Descriptive Data | ||||||||
| Marker for | ||||||||
| Subcellular Localization | ||||||||
| CV Term | ||||||||
| Notes | ||||||||
| Polypeptide Expression | ||||||||
| Additional Descriptive Data | ||||||||
| Marker for | ||||||||
| Subcellular Localization | ||||||||
| CV Term | ||||||||
| Notes | ||||||||
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High-Throughput Expression Data
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Expression Clusters
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External Data & Images
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| Alleles & Phenotypes | ||||||||
| Summary of Allele Phenotypes | ||||||||
Phenotype manifest
in Allele | ||||||||
| Classical Alleles ( 0 ) | ||||||||
| For All Classical Alleles Show | ||||||||
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| Alleles Carried on Transgenic Constructs
( 0 ) | ||||||||
| For All Alleles Carried on Transgenic Constructs Show | ||||||||
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| Aneuploid Aberrations | ||||||||
| Transgenic Constructs & Insertions
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| Transgenic Constructs | ||||||||
Type of
construct Name Expression
data | ||||||||
| Insertions | ||||||||
Type of insertions Name Expression
data | ||||||||
| Gene Ontology: Function, Process
& Cellular Component ( 1 unique term ) | ||||||||
| Terms Based on
Experimental Evidence ( 1 term ) | ||||||||
| Molecular Function | ||||||||
CV term References | ||||||||
inferred from direct assay | ||||||||
| Biological Process ( 0 terms) | ||||||||
| Cellular Component ( 0 terms) | ||||||||
| Terms Based on Predictions or
Assertions ( 1 term ) | ||||||||
| Molecular Function | ||||||||
CV term References | ||||||||
non-traceable author statement | ||||||||
| Biological Process ( 0 terms) | ||||||||
| Cellular Component ( 0 terms) | ||||||||
| Sequence Ontology: Class of Gene | ||||||||
| Interactions & Pathways | ||||||||
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Summary of Physical Interactions
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| Protein-protein | ||||||||
Interacting group
Assay
References | ||||||||
| Summary of Genetic Interactions | ||||||||
| Interacts with | Please look at the allele data
for full details of the genetic interactions Canp allele Gene References | |||||||
| External Data | ||||||||
| Linkouts | ||||||||
| Orthologs | ||||||||
| Genome-wide drosophilid orthologs | ||||||||
| Curated drosophilid orthologs | ||||||||
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| Stocks & Reagents | ||||||||
| Stocks Listed in FlyBase ( 0 ) | ||||||||
| Genomic Clones ( 0 ) | ||||||||
| cDNA Clones ( 0 ) | ||||||||
| cDNA Clones, Fully Sequenced | ||||||||
| BDGP DGC clones | ||||||||
| Other clones | ||||||||
| cDNA Clones, End Sequenced (ESTs) | ||||||||
| BDGP DGC clones | ||||||||
| Other clones | ||||||||
| RNAi & Array Information | ||||||||
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Antibody Information
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| Other Information | ||||||||
| Discoverer | ||||||||
| Etymology | ||||||||
| Identification | ||||||||
| Relationship to Other Genes | ||||||||
| Source for database identity of | ||||||||
| Source for database merge of | ||||||||
| Additional comments | "Canp" (purified and studied in FBrf0055463) is not the same as "CalpI" (partially purified and studied in FBrf0047562). The relationship between "Canp" and "CalpII" (partially purified and studied in FBrf0047562) is unknown. "Canp" is unlikely to be the same as "CalpA", since "Canp" protein is purified from the cytosol and "CalpA" is not detected in the cytosol with an anti-"CalpA" antibody. | |||||||
| Other Comments | ||||||||
The calcium-activated neutral protease (CANP) system in Drosophila has been isolated by a series of chromatographic steps. Proteolytic activity is absolutely Ca2+-dependent. Several of its properties resemble those of vertebrate calpain II. | ||||||||
| External Crossreferences & Linkouts
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| Sequence Crossreferences | ||||||||
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| Synonyms & Secondary IDs
( 6 ) | ||||||||
| Reported As | ||||||||
| Symbol Synonym | CANP Canp Ca-TPase nCAPII | |||||||
| Name Synonym | Ca2+-activated neutral protease Ca2+ activated thioprotease | |||||||
| Secondary FlyBase IDs | ||||||||
| References ( 4 ) | ||||||||
| Research paper |
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| Personal communication to FlyBase |
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| Abstract |
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