FlyBase Gene Report: Dmel\CanB

General Information

Symbol

Dmel\CanB

Species

D. melanogaster

Name

Calcineurin B

Annotation Symbol

CG4209

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010014

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase. (UniProt, P48451)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

CaN

Key Links

Genomic Location

Cytogenetic map

4F5-4F5

Sequence location

X:5,332,499..5,334,449 [+]

Recombination map

1-11

RefSeq locus

NC_004354 REGION:5332499..5334449

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR002048

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(Guerini et al., 1992)

enables calcium-dependent protein serine/threonine phosphatase regulator activity

inferred from electronic annotation with InterPro:IPR015757

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(Guerini et al., 1992)

enables calmodulin binding

inferred from sequence or structural similarity

(Guerini et al., 1992)

Biological Process (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in sleep

inferred from direct assay

(Nakai et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in neurotransmitter secretion

non-traceable author statement

(Lloyd et al., 2000)

involved_in protein dephosphorylation

inferred from sequence or structural similarity

(Guerini et al., 1992)

involved_in vesicle-mediated transport

non-traceable author statement

(Lloyd et al., 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of calcineurin complex

inferred from sequence or structural similarity

(Guerini et al., 1992)

located_in synaptic vesicle

non-traceable author statement

(Lloyd et al., 2000)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the calcineurin regulatory subunit family. (P48451)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

Calcineurin is a calcium-binding and calmodulin-binding protein found in all cells from yeast to mammals, and a calcium-dependent, calmodulin-stimulated protein phosphatase.

(UniProt, P48451)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CanB for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P48451)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.39

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

retrogene

(dos Santos, 2014, Bai et al., 2007, Langille and Clark, 2007, Betran et al., 2002)

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CanB-RA

FBtr0070764

NM_080002

1214

170

CanB-RB

FBtr0308348

NM_001258602

1148

170

Additional Transcript Data and Comments

Reported size (kB)

1.6 (northern blot)

(Guerini et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CanB-PA

FBpp0070731

19.3

170

4.29

NP_524741

AAF46026

CanB-PB

FBpp0300667

19.3

170

4.29

NP_001245531

AFH07245

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

170 aa isoforms: CanB-PA, CanB-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

170 (aa); 19.4 (kD)

(Guerini et al., 1992)

Comments

External Data

Subunit Structure (UniProtKB)

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

(UniProt, P48451)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CanB using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanB_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

adult stage

adult optic lobe

(Tomita et al., 2011)

adult brain

(Tomita et al., 2011)

retina

(Tomita et al., 2011)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Guerini et al., 1992)

Additional Descriptive Data

CanB is widely expressed in the adult brain, optic lobe, and retina.

(Tomita et al., 2011)

CanB transcripts are detected in embryo RNA.

(Guerini et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Tomita et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Protein was detected in the entire adult brain. An antibody agains a mammalian CnB subunit was used, which recognizes both CanB and CanB2 proteins.

(Tomita et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CanB in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CanB

View exonic expression by tissue for Dmel\CanB

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010014

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44317/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010014

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010014

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010014

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4209

Flygut - An atlas of the Drosophila adult midgut

FBgn0010014

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CanB

Stages(s) 1-3
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CanB

Transgenic constructs containing regulatory region of CanB

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CanB^d09902

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CanB^GD10703

viable, with Scer\GAL4^Mef2.PR

CanB^GD10703

viable, with Scer\GAL4^pnr-MD237

CanB^GD10703

viable, with Scer\GAL4^tin.CΔ4

CanB^GD10703

Sterility

Allele

fertile

CanB^d09902

Other Phenotypes

Allele

abnormal heat stress response | third instar larval stage, with Scer\GAL4^ppk.1.9

CanB^GD10703

abnormal locomotor behavior

CanB^KO

abnormal sleep

CanB^KO

wild-type

CanB^GMR.PS

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PPP3R1

12 of 15

Yes

7 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ppp3r1

14 of 15

Yes

7 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (17)

Rnor\Ppp3r1

9 of 13

Yes

Rnor\Ppp3r2

7 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Rnor\Rcvrn

1 of 13

Xenopus tropicalis (Western clawed frog) (17)

Xtro\ppp3r1

13 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Xtro\rcvrn.1

1 of 12

Xtro\rcvrn.2

1 of 12

Xtro\tesc

1 of 12

Yes

Danio rerio (Zebrafish) (27)

Drer\ppp3r1b

13 of 15

Yes

Drer\ppp3r1a

11 of 15

Yes

Drer\chp1

2 of 15

Drer\chp2

2 of 15

Drer\LOC100536377

2 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-103a14.5

1 of 15

Drer\si:ch211-245j22.3

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\cnb-1

14 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (25)

Atha\AT3G18430

6 of 9

Yes

Atha\CBL6

2 of 9

Atha\AGD11

1 of 9

Yes

Atha\AT1G05990

1 of 9

Yes

Atha\AT2G36180

1 of 9

Yes

Atha\AT3G03400

1 of 9

Yes

Atha\AT3G03410

1 of 9

Yes

Atha\AT3G59440

1 of 9

Yes

Atha\AT3G59450

1 of 9

Yes

Atha\AT4G03290

1 of 9

Yes

Atha\AT5G17470

1 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Yes

Atha\CPK30

1 of 9

Atha\MSS3

1 of 9

Yes

Atha\SOS3

1 of 9

Atha\TCH2

1 of 9

Yes

Atha\UNE14

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CNB1

13 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC830.06

11 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

9 of 10

elm

4 of 10

3 of 10

3 of 10

2 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

CanB^GD10703

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanB^GD17823

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

CanB^JF02616

ameliorates Alzheimer's disease

modeled by Hsap\APP^{695.UAS.Tag:MYC}

(Shaw et al., 2015, Shaw and Chang, 2013)

ameliorates epilepsy

modeled by zyd¹

(Weiss et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP3R1; protein phosphatase 3 regulatory subunit B, alpha

12 of 15

601302

PPP3R2; protein phosphatase 3 regulatory subunit B, beta

7 of 15

613821

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CanB - CanB2

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CanB|Pp2B-14D

enhanceable

CE2-2

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

enhanceable

CE2-3

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

enhanceable

CE3-2

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

suppressible

CS3-1

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

suppressible

CS3-2

(Sullivan and Rubin, 2002)

Pp2B-14D|CanB

enhanceable

Egfr

(Sullivan and Rubin, 2002)

Pp2B-14D|CanB

enhanceable

pnt

(Sullivan and Rubin, 2002)

Pp2B-14D|CanB

enhanceable

Ras85D

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

suppressible

RasGAP1

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

suppressible

(Sullivan and Rubin, 2002)

CanB|Pp2B-14D

suppressible

sty

(Sullivan and Rubin, 2002)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

CanB2

suppressible

CanB

(Sullivan and Rubin, 2002)

Pp2B-14D

enhanceable

CanB

(Sullivan and Rubin, 2002)

External Data

Subunit Structure (UniProtKB)

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

(UniProt, P48451 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68974

DroID - A comprehensive database of gene and protein interactions.

FBgn0010014

MIST (protein-protein) - An integrated Molecular Interaction Database

CanB

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-11

Cytogenetic map

4F5-4F5

Sequence location

X:5,332,499..5,334,449 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

4F5-4F5

Limits computationally determined from genome sequence between P{EP}EP425 and P{EP}CG3249^EP1400

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

4F-4F

(Lloyd et al., 2000, Guerini, 1992.11.30)

4F-4F

(determined by in situ hybridisation)

(Guerini et al., 1992)

Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.

(Lloyd et al., 2000)

Experimentally Determined Recombination Data

Location

1-11

(FlyBase, 2016)

1-13.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19323

w¹¹¹⁸ P{XP}CanB^d09902

27307

y¹ v¹; P{TRiP.JF02616}attP2

82080

y¹ v¹; P{TKO.GS04845}attP40

FlyORF

F002706

M{UAS-CanB.ORF.3xHA.GW}ZH-86Fb

VDRC

v21611

w¹¹¹⁸; P{GD10703}v21611

v52390

w¹¹¹⁸; P{GD17823}v52390

v342514

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01966}attP40/CyO-GFP

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (45)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_RH02643

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010014

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010014

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44317

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: CanB CG4209

(Bayraktaroglu, 2000.4.12)

Additional comments

The CanB gene may have been derived from the CanB2 gene by retroposition.

(Bai et al., 2007, Langille and Clark, 2007, Langille and Clark, 2007)

The CanB gene may be derived from the CanB2 gene by retroposition.

(Betran et al., 2002)

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Identified with: RH11383 (BDGP-DGC) <up>FlyBase curator comment: EST subsequently found to be chimeric</up>.

(BDGP Project Members, 2000-)

EST RH11383 is chimeric; the 5' portion corresponds to part of CG15295, the 3' portion corresponds to part of CanB.

(FlyBase, 1996-)

CanB2 has been cloned and sequenced, and compared with CanB.

(Warren et al., 1996)

Two subunits of Drosophila calcineurin have been cloned.

(Guerini et al., 1992)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 47 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44317

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P48451

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P48451

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9NFW6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P48451

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010014

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010014

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44317/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010014

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanB_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010014

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010014

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4209

Flygut - An atlas of the Drosophila adult midgut

FBgn0010014

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

44317

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007534

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4209

MARRVEL_MODEL - MARRVEL (model organism gene)

44317

modMine - A data warehouse for the modENCODE project

FBgn0010014

Linkouts

BioGRID - A database of protein and genetic interactions.

68974

DroID - A comprehensive database of gene and protein interactions.

FBgn0010014

DRSC - Results frm RNAi screens

FBgn0010014

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010014

FlyMine - An integrated database for Drosophila genomics

FBgn0010014

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

CanB

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

BcDNA:RH11383

CG4209

(Honjo et al., 2016, Kanamori et al., 2013)

CNB

(Guerini, 1992.11.30)

CaN

(Funk et al., 2020, Toprak et al., 2020)

CaNB

(Shaw et al., 2015, Shaw and Chang, 2013)

Calcineurin B

(Edwards et al., 2006)

Can

CnB

(Tomita et al., 2011)

canB

(Kanamori et al., 2013)

canB-4F

(Sullivan and Rubin, 2002)

dCnB1

(Warren et al., 1996)

Name Synonyms

Calcineurin B

(Tomita et al., 2017, Tomita et al., 2011, Edwards et al., 2006)

Calcineurin1

(Kollmar, 2006)

calcineurin B

(Cavieres-Lepe and Ewer, 2021, Honjo et al., 2016)

Secondary FlyBase IDs

FBgn0004466
FBgn0029757
FBgn0047037

Datasets (6)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (6)

Result

Result Type

Title

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (79)

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