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Gene Dmel\CanA1

General Information
Symbol	Dmel\CanA1	Species	D. melanogaster
Name	Calcineurin A1	Annotation symbol	CG1455
Feature type	protein_coding_gene	FlyBase ID	FBgn0010015
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	PP2B 21EF
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100B1-100B1	Sequence location	3R:26,865,098..26,872,543 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Calcineurin A1 is referred to in FlyBase by the symbol Dmel\CanA1 (CG1455, FBgn0010015). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium-dependent protein serine/threonine phosphatase activity; protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process: sleep. 8 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval Malpighian tubules, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632216_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CanA1. Gene sequence location is 3R:26865098..26872543.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms sleep Transgenic Constructs P{UAS-CanA1.act} References Nakai et al., 2011, J. Neurosci. 31(36): 12759--12766 Alleles CanA1[Act.Scer\UAS] CanA1[KO]
FB2012_01	Sequence features BKN33273 HFA16600 BKN60439 BKN60030
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100B1-100B1   Limits computationally determined from genome sequence between P{lacW}l(3)s2500s2500 and P{PZ}Aph-407028&P{PZ}dcorK215
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100B2-100B2   (determined by in situ hybridisation)   (Yang et al., 2000) 21E-21F     (Guerini, 1992.11.30) 21E-21F   (determined by in situ hybridisation)   (Guerini et al., 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CanA1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CanA1-RA FBtr0085732  NM_079861   2626   622 CanA1-RB FBtr0304582     2548   596 CanA1-RC FBtr0304583     2541   462
Additional Transcript Data & Comments
Reported size (kB)	1.998 (compiled cDNA) (Guerini et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CanA1-PA   FBpp0085094   69.1   622   7.82     NP_524600   AAF57105 CanA1-PB   FBpp0293124   66.3   596   7.24       CanA1-PC   FBpp0293125   52.2   462   5.88
Additional Polypeptide Data & Comments
Reported size (kDa)	568 (aa); 65 (kD) (Guerini et al., 1992)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57105   AC007975   AC008220   AI386714   AY128480 AAM75073   BI368561   BI369103   CK658216   CK658791   CO189344   CO189348   CO280136   CO291965   CO313840   CO321179   CZ484263   CZ484264   EC053571   EC055089   EC055897   EC056387   EC057848   EC086418   EC088158   EC233249   EC241198   EC245137   M97012 AAA28410   S39996 AAB22466
UniProtKB/Swiss-Prot	P48456
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	CanA1 transcripts are not detected in any stages on northern blots presumably due to low abundance. (Guerini et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010015    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010015 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed within 18-24 hour embryonic stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010015 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr    1682 embryo 20-22hr    1928 embryo 22-24hr    1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP    2756 adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr  (151) embryo 18-20hr  (1682) embryo 20-22hr  (1928) embryo 22-24hr  (1831) larva L1  (640) larva L2  (737) larva L3 12hr old  (901) larva L3 puffstage 1-2  (681) larva L3 puffstage 3-6  (799) larva L3 puffstage 7-9  (731) white prepupae new  (199) white prepupae 12hr  (173) white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP  (875) pupae 4d postWPP  (2756) adult male 01day  (885) adult male 05day  (833) adult male 30day  (698) adult female 01day  (619) adult female 05day  (134) adult female 30day  (109) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr  (1682) embryo 20-22hr  (1928) embryo 22-24hr  (1831) larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP  (2756) adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr    1682 embryo 20-22hr    1928 embryo 22-24hr    1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP    2756 adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr    1682 embryo 20-22hr    1928 embryo 22-24hr    1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP    2756 adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010015 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr    1682 embryo 20-22hr    1928 embryo 22-24hr    1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP    2756 adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr  (151) embryo 18-20hr  (1682) embryo 20-22hr  (1928) embryo 22-24hr  (1831) larva L1  (640) larva L2  (737) larva L3 12hr old  (901) larva L3 puffstage 1-2  (681) larva L3 puffstage 3-6  (799) larva L3 puffstage 7-9  (731) white prepupae new  (199) white prepupae 12hr  (173) white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP  (875) pupae 4d postWPP  (2756) adult male 01day  (885) adult male 05day  (833) adult male 30day  (698) adult female 01day  (619) adult female 05day  134 adult female 30day  109 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr  1682 embryo 20-22hr  1928 embryo 22-24hr  1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP  (2756) adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr    1682 embryo 20-22hr    1928 embryo 22-24hr    1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP    2756 adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    7 embryo 04-06hr    4 embryo 06-08hr    34 embryo 08-10hr    76 embryo 10-12hr    8 embryo 12-14hr    9 embryo 14-16hr    20 embryo 16-18hr    151 embryo 18-20hr    1682 embryo 20-22hr    1928 embryo 22-24hr    1831 larva L1    640 larva L2    737 larva L3 12hr old    901 larva L3 puffstage 1-2    681 larva L3 puffstage 3-6    799 larva L3 puffstage 7-9    731 white prepupae new    199 white prepupae 12hr    173 white prepupae 24hr    33 pupae 2d postWPP    83 pupae 3d postWPP    875 pupae 4d postWPP    2756 adult male 01day    885 adult male 05day    833 adult male 30day    698 adult female 01day    619 adult female 05day    134 adult female 30day    109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010015    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010015 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, larval Malpighian tubules, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010015 expression level Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass    595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass  (595.05) Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass    595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass    595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010015 expression level Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass    595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass  595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass    595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    15.625 Larval Midgut no informative data Larval Hindgut    71 Larval Malpighian Tubules    313 Larval Fat Body    8.8 Larval Salivary Gland    8.5 Larval Trachea    16.775 Larval Carcass    595.05 Adult Head    47.3 Adult Eye    7.2 Adult Brain    6.6 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    272.7 Adult Midgut    21.4 Adult Hindgut    141.5 Adult Malpighian Tubules    70.2 Adult Fat Body    20.1 Adult Salivary Gland no informative data Adult Heart    67.9 Adult VirginFemale Spermatheca    27.3 Adult InseminatedFemale Spermatheca    31.2 Adult Ovary    3.2 Adult Testis    6 Adult Male Accessory Gland no informative data Adult Carcass    200.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    47.3   NA  Eye    7.2   NA  Brain    6.6   15.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    272.7   no informative data  Midgut    21.4   71  Hindgut    141.5   313  Malpighian Tubules    70.2   8.8  Fat Body    20.1   8.5  Salivary Gland    no informative data   NA  Heart    67.9   16.775  Trachea    NA   NA  VirginFemale Spermatheca    27.3   NA  InseminatedFemale Spermatheca    31.2   NA  Ovary    3.2   NA  Testis    6   NA  Male Accessory Gland    no informative data   595.05  Carcass    200.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010015 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1455-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 CanA1GD8366 CanA1GD16976 Other Phenotypes Allele locomotor behavior defective CanA1Act.Scer\UAS CanA1KO sleep defective CanA1Act.Scer\UAS CanA1KO visible, with Scer\GAL4pnr-MD237 CanA1GD16976 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 CanA1GD16976 trichogen cell, with Scer\GAL4pnr-MD237 CanA1GD16976
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CanA1 Class Mutagen Stocks Known lesion CanA1f01787 piggyBac transposase 1 -- CanA1MB11454 1 -- CanA1NP2738 1 -- CanA1KO ends-out gene targeting SCEI endonuclease FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CanA1 Class Mutagen Stocks Known lesion CanA1GD16976 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CanA1GD8366 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CanA1JF01871 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CanA1Act.Scer\UAS in vitro construct - site directed mutagenesis in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6260 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8366} NA P{GD16976} NA P{TRiP.JF01871} NA P{UAS-CanA1.act} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}CanA1MB11454 No P{GawB}CanA1NP2738 No miscellaneous insertions PBac{WH}CanA1f01787 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
sleep inferred from direct assay (Nakai et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
calcium-dependent protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Guerini et al., 1992) non-traceable author statement (Guerini, 1992.11.30, Swiss-Prot Project Members, 1996.2.1) hydrolase activity inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186 (FlyBase Curators et al., 2004-) protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Chen et al., 1992) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) protein dephosphorylation inferred from sequence or structural similarity (Chen et al., 1992, Guerini et al., 1992) non-traceable author statement (Morrison et al., 2000, Swiss-Prot Project Members, 1996.2.1) vesicle-mediated transport non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
calcineurin complex inferred from sequence or structural similarity (Guerini et al., 1992) non-traceable author statement (Guerini, 1992.11.30, Swiss-Prot Project Members, 1996.2.1) synaptic vesicle non-traceable author statement (Lloyd et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CanA1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68520 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010015 DroID - A comprehensive database of gene and protein interactions. • FBgn0010015 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43670
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH13969 Dmoj\GI22313 Dper\GL13533 Dpse\GA26888 Dsec\GM12918 Dyak\GE10915
Curated drosophilid orthologs	Dmad\CanA1 (Munte, 2004.9.23) Dpse\GA13075   Dsub\CanA1 (Munte, 2004.9.23)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • Chro.60481 Cryptosporidium hominis (obligate parasite) cgd6_4200 Cryptosporidium parvum (protozoan parasite) XP_657065 Entamoeba histolytica (anaerobic protozoan) GL50803_16570 Giardia lamblia (flagellated protozoan) LmjF26.2530 Leishmania major (virus) PF08_0129 Plasmodium falciparum (protozoal parasite) 136608 Phytophthora sojae (root rot pathogen) PVX_093605 Plasmodium vivax (protozoal parasite) YML057W Saccharomyces cerevisiae (budding yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12529 NV13244 LH17508 ISCW024405 FBgn0228747 FBgn0227202 FBgn0224584 FBgn0197780 FBgn0192983 FBgn0187403 FBgn0168321 FBgn0167850 JGI_V11_312053 JGI_V11_62512 FBgn0248260 FBgn0157569 FBgn0151138 FBgn0145041 FBgn0137904 FBgn0011826 FBgn0132345 FBgn0121445 FBgn0110463 FBgn0104083 FBgn0099928 FBgn0097802 FBgn0097800 CPIJ018692 BGIBMGA006850 ACYPI003343 GB12904 AGAP001279 AAEL008930 PHUM596230 GLEAN_00103
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	29211 w1118; Mi{ET1}CanA1MB11454 25850 y1 v1; P{TRiP.JF01871}attP2
Harvard	- PBac{WH}CanA1f01787
Kyoto	104305 w*; P{GawB}CanA1NP2738 / TM3, Sb1 Ser1
VDRC	v32283 w1118; P{GD8366}v32283 v32284 w1118; P{GD8366}v32284/CyO v49986 w1118; P{GD16976}v49986/CyO v49987 w1118; P{GD16976}v49987/CyO
Genomic Clones ( 2 )
	BACR06P08 BACR11C03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 22 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE54552
Other clones	DPiM_RE54552
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH16889 LP14981 LP16035 RE55201
Other clones	19169 39167 69744 107763 CK01.54A.A2 CK01.54A.B2 EC053571 EC055089 EC055897 EC056387 EK044033 EK044037 EK152714 EK198862 EK234163 EK290443
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010015 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43670
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CanA1 CG1455 (Yao, 1999.11)
Source for database merge of	Source for merge of: CanA1 PpD14 (Bayraktaroglu, 2000.8.7)
Additional comments	The CanA-14F gene may be derived from the CanA1 gene by retroposition. (Betran et al., 2002)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Two subunits of Drosophila calcineurin have been cloned. (Guerini et al., 1992) The primary structure, amino acid sequence and regulation of CanA1 has been determined and compared to human and bovine calcineurin proteins. (Klee and Guerini, 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079861 RefSeq (Proteins) • NP_524600 DDBJ / EMBL / GenBank • AAA28410 AAB22466 AAF57105 AAM75073 AC007975 AC008220 AY128480 BI368561 CZ484263 CZ484264 M97012 S39996 Entrez Gene - A searchable database of RefSeq genes. • 43670 UniProtKB/Swiss-Prot • P48456
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68520 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0010015 DroID - A comprehensive database of gene and protein interactions. • FBgn0010015 DRSC - Results from RNAi screens. • FBgn0010015 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010015 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1455-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010015 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43670 InParanoid A subset of ortholog calls from InParanoid. • Chro.60481 Cryptosporidium hominis (obligate parasite) cgd6_4200 Cryptosporidium parvum (protozoan parasite) XP_657065 Entamoeba histolytica (anaerobic protozoan) GL50803_16570 Giardia lamblia (flagellated protozoan) LmjF26.2530 Leishmania major (virus) PF08_0129 Plasmodium falciparum (protozoal parasite) 136608 Phytophthora sojae (root rot pathogen) PVX_093605 Plasmodium vivax (protozoal parasite) YML057W Saccharomyces cerevisiae (budding yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43670 modMine - Data generated by the modENCODE project. • FBgn0010015 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12529 NV13244 LH17508 ISCW024405 FBgn0228747 FBgn0227202 FBgn0224584 FBgn0197780 FBgn0192983 FBgn0187403 FBgn0168321 FBgn0167850 JGI_V11_312053 JGI_V11_62512 FBgn0248260 FBgn0157569 FBgn0151138 FBgn0145041 FBgn0137904 FBgn0011826 FBgn0132345 FBgn0121445 FBgn0110463 FBgn0104083 FBgn0099928 FBgn0097802 FBgn0097800 CPIJ018692 BGIBMGA006850 ACYPI003343 GB12904 AGAP001279 AAEL008930 PHUM596230 GLEAN_00103
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	Can   canA (Sullivan and Rubin, 2002) CanA1 (Takeo et al., 2006, Stuart et al., 2007, Ha et al., 2009, Dijkers and O'Farrell, 2007, Philipps et al., 2004, Nakai et al., 2011) Cana1 (Bandyopadhyay et al., 2006) CAN A1/PP2B (Morrison et al., 2000) CG1455 (Morrison et al., 2000, Perkins et al., 1.15.2009, Philipps et al., 2004) CNA1 (Guerini, 1992.11.30) CnnA21EF (Hong and Ganetzky, 1996) D14 (Chen et al., 1992) DmCanA1-100B (Cohen, 2005) pMY4 (Yang et al., 2000) PP2B (Helps et al., 1998) PP2B 21EF (Cohen, 1997, Brown et al., 1994) PpD14   unnamed (Lloyd et al., 2000)
Name Synonym	calcineurin (Sullivan and Rubin, 2002, Sullivan and Rubin, 2000, Dijkers and O'Farrell, 2007) Calcineurin (Dijkers and O'Farrell, 2007) Calcineurin A1   Protein phosphatase D14   protein phosphatase from PCR fragment D14 (Chen, 1993.1.7)
Secondary FlyBase IDs
	FBgn0004466 FBgn0005780
References ( 52 )
Generate a list of	All references relating to this gene ( 52 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 4 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Nakai et al., 2011, J. Neurosci. 31(36): 12759--12766 Calcineurin and Its Regulator Sra/DSCR1 Are Essential for Sleep in Drosophila. [FBrf0215272] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...