FlyBase Gene Report: Dmel\CanA1

General Information

Symbol

Dmel\CanA1

Species

D. melanogaster

Name

Calcineurin A1

Annotation Symbol

CG1455

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010015

Gene Model Status

Current

Stock Availability

11 publicly available

Gene Snapshot

Contributions welcome

Other Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

calcineurin, PP2B 21EF, CaN

Key Links

Genomic Location

Cytogenetic map

100B1-100B1

Sequence location

3R:31,039,374..31,046,821 [+]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31039374..31046821

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (14 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables calcium-dependent protein serine/threonine phosphatase activity

inferred from sequence or structural similarity

(Guerini et al., 1992)

enables calmodulin binding

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

enables calmodulin-dependent protein phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein serine/threonine phosphatase activity

inferred from sequence or structural similarity

(Chen et al., 1992)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in medium-term memory

inferred from direct assay

(Tomita et al., 2011)

involved_in negative regulation of epidermal growth factor receptor signaling pathway

inferred from genetic interaction with FLYBASE:Egfr; FB:FBgn0003731

(Sullivan and Rubin, 2002)

involved_in regulation of innate immune response

inferred from direct assay

(Dijkers and O'Farrell, 2007)

involved_in response to nitric oxide

inferred from direct assay

(Dijkers and O'Farrell, 2007)

involved_in sleep

inferred from direct assay

(Nakai et al., 2011, Tomita et al., 2011)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in calcineurin-mediated signaling

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in protein dephosphorylation

inferred from sequence or structural similarity

(Chen et al., 1992, Guerini et al., 1992)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of calcineurin complex

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity

(Guerini et al., 1992)

located_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000746105

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in synaptic vesicle

non-traceable author statement

(Lloyd et al., 2000)

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Pathway (FlyBase)

Negative Regulators of EGFR Signaling Pathway

Protein Family (UniProt)

Belongs to the PPP phosphatase family. PP-2B subfamily. (P48456)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PPP FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: The Phosphoprotein Phosphatase (PPP) family members are serine/threonine phosphatases. They often function in association with regulatory subunits. (Adapted from PMID:11230548 and PMID:19879837).

Pathway (FlyBase)

Negative Regulators of EGFR Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.

Protein Function (UniProtKB)

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

(UniProt, P48456)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CanA1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CanA1-RA

FBtr0085732

NM_079861

2628

622

CanA1-RB

FBtr0304582

NM_001260448

2530

596

CanA1-RD

FBtr0334546

NM_001260449

3064

622

Additional Transcript Data and Comments

Reported size (kB)

1.998 (compiled cDNA)

(Guerini et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CanA1-PA

FBpp0085094

69.1

622

7.82

NP_524600

AAF57105

CanA1-PB

FBpp0293124

66.3

596

7.24

NP_001247377

AFH06694

CanA1-PD

FBpp0306613

69.1

622

7.82

NP_001247378

AFH06695

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

622 aa isoforms: CanA1-PA, CanA1-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

568 (aa); 65 (kD)

(Guerini et al., 1992)

Comments

External Data

Subunit Structure (UniProtKB)

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

(UniProt, P48456)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CanA1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanA1_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

Additional Descriptive Data

CanA1 transcripts are not detected in any stages on northern blots presumably due to low abundance.

(Guerini et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CanA1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CanA1

View exonic expression by tissue for Dmel\CanA1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010015

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010015

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1455-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1455

Flygut - An atlas of the Drosophila adult midgut

FBgn0010015

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CanA1

Transgenic constructs containing regulatory region of CanA1

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation

Gene disrupted in

Df(3R)Exel6260

(Ryder, 2004.4.26)

Inferred from location

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

partially lethal - majority live, with Scer\GAL4^elav.PU

CanA1^JF01871

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CanA1^GD8366

viable, with Scer\GAL4^Mef2.PR

CanA1^GD8366

viable, with Scer\GAL4^tin.CΔ4

CanA1^GD8366

Other Phenotypes

Allele

abnormal locomotor behavior

abnormal memory, with Scer\GAL4^elav-C155

CanA1^GD16976

abnormal sleep

abnormal sleep, with Scer\GAL4^elav-C155

CanA1^GD16976

hypoactive, with Scer\GAL4^elav-C155

CanA1^GD16976

some die during pupal stage, with Scer\GAL4^pnr-MD237

visible, with Scer\GAL4^pnr-MD237

CanA1^GD16976

Phenotype manifest in

Allele

embryonic/larval glial cell | increased number, with Scer\GAL4^elav.PU

CanA1^JF01871

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CanA1^GD16976

mitochondrion | adult stage

CanA1^f01787

trichogen cell, with Scer\GAL4^pnr-MD237

CanA1^GD16976

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (14)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PPP3CB

10 of 15

Yes

9 of 15

9 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Hsap\PPP6C

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (13)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ppp3cb

10 of 15

Yes

9 of 15

8 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (12)

Rnor\Ppp3cc

8 of 13

Yes

7 of 13

6 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (12)

Xtro\ppp3cc

9 of 12

Yes

Xtro\ppp3ca

7 of 12

Xtro\ppp3cb

7 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (17)

Drer\ppp3cca

8 of 15

Yes

Drer\ppp3ccb

8 of 15

Yes

6 of 15

5 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (44)

Cele\tax-6

11 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Cele\ZK354.9

1 of 15

Cele\ZK938.1

1 of 15

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (13)

Scer\CMP2

12 of 15

Yes

10 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ppb1

9 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919065Z )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA26888

Drosophila persimilis

Dper\GL13533

Drosophila willistoni

Dwil\GK22607

Drosophila virilis

Dvir\GJ10500

Drosophila mojavensis

Dmoj\GI22313

Drosophila grimshawi

Dgri\GH13969

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503T8 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17011595

Musca domestica

House fly

Mdoa\17011777

Musca domestica

House fly

Mdoa\17018175

Glossina morsitans

Tsetse fly

Gmor\GMOY008907

Glossina morsitans

Tsetse fly

Gmor\GMOY008078

Glossina morsitans

Tsetse fly

Gmor\GMOY007597

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10408

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_11822

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02720

Mayetiola destructor

Hessian fly

Mdes\Mdes002974

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008930

Anopheles darlingi

American malaria mosquito

Adar\ADAC008703

Anopheles gambiae

Malaria mosquito

Agam\AGAP001279

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ018692

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03LH )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\cna

Danaus plexippus

Monarch butterfly

Dple\DPOGS206069-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL005036

Apis florea

Little honeybee

Aflo\2201296148

Apis mellifera

Western honey bee

Amel\LOC411046

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP18082

Bombus terrestris

Buff-tailed bumblebee

Bter\15216049

Linepithema humile

Argentine ant

Lhum\LH25683

Linepithema humile

Argentine ant

Lhum\LH17508

Linepithema humile

Argentine ant

Lhum\LH17500

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0011e2

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007022

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007393

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09979

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_09950

Tribolium castaneum

Red flour beetle

Tcas\TC000103

Pediculus humanus

Human body louse

Phum\PHUM596230

Rhodnius prolixus

Kissing bug

Rpro\RPRC009380

Cimex lectularius

Bed bug

Clec\CLEC001543

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI003343

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08435

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03IC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Ixodes scapularis

Black-legged tick

Isca\ISCW024405

Stegodyphus mimosarum

African social velvet spider

Smim\KFM63371.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM80850.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g07540

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g07560

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_62512

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_312053

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G094R )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cnbs

Ciona intestinalis

Vase tunicate

Cint\LOC100185597

Gallus gallus

Domestic chicken

Ggal\LOC769842

Gallus gallus

Domestic chicken

Ggal\PPP3CB

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (18)

Gene Symbol

Score

Source

Alignment

8 of 10

7 of 10

2 of 10

flw

2 of 10

mts

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

PpV

2 of 10

PpY-55A

2 of 10

rdgC

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PPP3CB; protein phosphatase 3 catalytic subunit beta

10 of 15

114106

PPP3CA; protein phosphatase 3 catalytic subunit alpha

9 of 15

114105

infantile or early childhood epileptic encephalopathy 1

PPP3CC; protein phosphatase 3 catalytic subunit gamma

9 of 15

114107

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CanA1 - Pp2B-14D

experimental knowledge based

(Guruharsha et al., 2011)

CanA1 - Rel

anti tag coimmunoprecipitation, anti tag western blot

(Dijkers and O'Farrell, 2007)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.

(UniProt, P48456 )

Linkouts

BioGRID - A database of protein and genetic interactions.

68520

DroID - A comprehensive database of gene and protein interactions.

FBgn0010015

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43670

MIST (protein-protein) - An integrated Molecular Interaction Database

CanA1

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of EGFR Signaling Pathway -: Negative regulators of Epidermal Growth Factor Receptor signaling down-regulate the pathway, suppressing the activation of ERK kinase (rl) or acting on downstream effectors.

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

100B1-100B1

Sequence location

3R:31,039,374..31,046,821 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100B1-100B1

Limits computationally determined from genome sequence between P{lacW}l(3)s2500^s2500 and P{PZ}Aph-4⁰⁷⁰²⁸&P{PZ}dco^rK215

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

100B2-100B2

(determined by in situ hybridisation)

(Yang et al., 2000)

21E-21F

(Guerini, 1992.11.30)

21E-21F

(determined by in situ hybridisation)

(Guerini et al., 1992)

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-98.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

83343

w¹¹¹⁸; P{UAS-CanA1.Δ.HA}4B

29211

w¹¹¹⁸; Mi{ET1}CanA1^MB11454

25850

y¹ v¹; P{TRiP.JF01871}attP2

80327

y¹ v¹; P{TKO.GS03287}attP40

42342

y¹ w^*; Mi{MIC}CanA1^MI05747

43015

y¹ w^*; Mi{MIC}CanA1^MI05596

Kyoto

104305

w^*; P{GawB}CanA1^NP2738 / TM3, Sb¹ Ser¹

VDRC

v32283

w¹¹¹⁸; P{GD8366}v32283

v32284

w¹¹¹⁸; P{GD8366}v32284/CyO

v341038

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00041}attP40/CyO-GFP

v341453

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00523}attP40/CyO-GFP

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (18)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE54552

Other clones

DPiM_RE54552

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010015

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010015

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43670

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CanA1 CG1455

(Yao, 1999.11)

Source for database merge of

Source for merge of: CanA1 PpD14

(Bayraktaroglu, 2000.8.7)

Additional comments

The CanA-14F gene may be derived from the CanA1 gene by retroposition.

(Betran et al., 2002)

Other Comments

CanA1 mediates the action of nitric oxide.

(Dijkers and O'Farrell, 2007)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Two subunits of Drosophila calcineurin have been cloned.

(Guerini et al., 1992)

The primary structure, amino acid sequence and regulation of CanA1 has been determined and compared to human and bovine calcineurin proteins.

(Klee and Guerini, 1990)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43670

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P48456

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010015

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010015

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CanA1_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1455

Flygut - An atlas of the Drosophila adult midgut

FBgn0010015

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

43670

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000103

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1455

modMine - A data warehouse for the modENCODE project

FBgn0010015

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P48456

Linkouts

BioGRID - A database of protein and genetic interactions.

68520

DPiM - Drosophila Protein interaction map

FBgn0010015

DroID - A comprehensive database of gene and protein interactions.

FBgn0010015

DRSC - Results frm RNAi screens

FBgn0010015

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0010015

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1455-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010015

FlyMine - An integrated database for Drosophila genomics

FBgn0010015

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

43670

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Wnt signaling pathway

MIST (protein-protein) - An integrated Molecular Interaction Database

CanA1

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (23)

Reported As

Symbol Synonym

CAN A1/PP2B

(Morrison et al., 2000)

CG1455

(Fukuoh et al., 2014, Kanamori et al., 2013, Perkins et al., 2009.1.15, Philipps et al., 2004, Morrison et al., 2000)

CNA1

(Guerini, 1992.11.30)

CaN

(Toprak et al., 2020, Sartain and Wolfner, 2013)

Can

CanA1

(Deng et al., 2020, Al-Ramahi et al., 2018, Stephano et al., 2018, Transgenic RNAi Project members, 2017-, Lee et al., 2016, Di Cara et al., 2015, Li and Dijkers, 2015, Pfluger et al., 2015, Heimiller et al., 2014, Friedman et al., 2011, Nakai et al., 2011, Tomita et al., 2011, Ha et al., 2009, Dijkers and O'Farrell, 2007, Langille and Clark, 2007, Stuart et al., 2007, Takeo et al., 2006, Philipps et al., 2004)

Cana1

(Bandyopadhyay et al., 2006)

CnA

(Tomita et al., 2011)

CnnA21EF

(Hong and Ganetzky, 1996)

D14

(Chen et al., 1992)

DmCanA1-100B

(Cohen et al., 2005)

PP2B

(Helps et al., 1998)

PP2B 21EF

(Cohen, 1997, Brown et al., 1994)

PpD14

canA

(Sullivan and Rubin, 2002)

canA1

(Li et al., 2020, Gupta et al., 2014, Wong et al., 2014, Kanamori et al., 2013)

pMY4

(Yang et al., 2000)

Name Synonyms

Calcineurin

(Dijkers and O'Farrell, 2007)

Calcineurin A

(Tomita et al., 2011)

Calcineurin A1

(Li and Dijkers, 2015, Gupta et al., 2014)

Protein phosphatase D14

calcineurin

(Potdar and Sheeba, 2013, Sartain and Wolfner, 2013, Dijkers and O'Farrell, 2007, Sullivan and Rubin, 2002, Sullivan and Rubin, 2000)

protein phosphatase from PCR fragment D14

(Chen, 1993.1.7)

Secondary FlyBase IDs

FBgn0004466
FBgn0005780

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (90)

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