FB2020_06, released Dec 22, 2020

Gene: Dmel\Cyp4g1

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General Information
Symbol
Dmel\Cyp4g1
Species
D. melanogaster
Name
Cytochrome P450-4g1
Annotation Symbol
CG3972
Feature Type
protein_coding_gene
FlyBase ID
FBgn0010019
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes. [Date last reviewed: 2020-01-16]
Other Summaries
Also Known As

T1, ASC-T1, P450, EG:165H7.1 , scγ

Key Links
Genomic Location
Cytogenetic map
1B4-1B4
Sequence location
X:467,057..469,335 [-]
Recombination map

1-0

RefSeq locus
NC_004354 REGION:467057..469335
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables aldehyde decarbonylase activity
inferred from mutant phenotype
(Qiu et al., 2012)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables heme binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables iron ion binding
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in cuticle hydrocarbon biosynthetic process
inferred from mutant phenotype
(Qiu et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in oxidation-reduction process
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome P450 family. (Q9V3S0)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
ALDEHYDE DECARBONYLASES -
Aldehyde decarbonylases catalyze the conversion of an aldehyde into an alkane by the removal of the carboxyl carbon. (Adapted from PMID:6593720).
OTHER CYTOCHROMES P450 -
The 'Other cytochromes P450' group comprises P450 enzymes that do not fit into the other major groups.
Protein Function (UniProtKB)
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
(UniProt, Q9V3S0)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cyp4g1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cyp4g1-RA
FBtr0070099
NM_080292
2279
556
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cyp4g1-PA
FBpp0070094
63.0
556
7.47
NP_525031
AAF45503
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

59 (kD)

(Sundseth et al., 1989)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp4g1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
embryonic/larval oenocyte
(Fisher et al., 2012)
embryonic stage 1 -- 2
organism

Comment: maternal

(Chung et al., 2009)
embryonic stage 7 -- 16
embryonic/larval oenocyte
(Chung et al., 2009)
third instar larval stage
embryonic/larval oenocyte
(Chung et al., 2009)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
organism

Comment: induced after emergence

(Storelli et al., 2019)
Additional Descriptive Data

Cyp4g1 expression is induced after emergence and peaks at day 2.

(Storelli et al., 2019)

Cyp4g1 transcripts are present in equal levels in an insecticide resistant strain (91-R) and a susceptible strain (91-C).

(Waters et al., 1992)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 16
embryonic/larval oenocyte
(Brodu et al., 2004)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Cyt-P450-A1 protein was found in all insecticide resistant and susceptible strains tested.

(Sundseth et al., 1989)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp4g1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cyp4g1
Transgenic constructs containing regulatory region of Cyp4g1
Deletions and Duplications ( 6 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CYP4V2
5 of 15
Yes
No
Hsap\CYP19A1
3 of 15
No
No
Hsap\CYP4B1
2 of 15
No
No
Hsap\CYP4F2
2 of 15
No
No
Hsap\CYP4F3
2 of 15
No
No
Hsap\CYP4F8
2 of 15
No
No
Hsap\CYP4F11
2 of 15
No
No
Hsap\CYP4F12
2 of 15
No
No
Hsap\CYP4F22
2 of 15
No
No
Hsap\CYP4X1
2 of 15
No
No
Hsap\CYP4A11
1 of 15
No
No
Hsap\CYP4A22
1 of 15
No
No
Hsap\CYP4Z1
1 of 15
No
No
Hsap\CYP8B1
1 of 15
No
Yes
Hsap\CYP20A1
1 of 15
No
Yes
Hsap\CYP26A1
1 of 15
No
No
Hsap\CYP26B1
1 of 15
No
No
Hsap\CYP26C1
1 of 15
No
No
Hsap\CYP46A1
1 of 15
No
No
Hsap\XPNPEP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (30)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cyp4v3
5 of 15
Yes
No
Mmus\Cyp19a1
3 of 15
No
No
Mmus\Cyp4a12a
2 of 15
No
No
Mmus\Cyp4a12b
2 of 15
No
No
Mmus\Cyp4a14
2 of 15
No
No
Mmus\Cyp4a29
2 of 15
No
No
Mmus\Cyp4a30b
2 of 15
No
No
Mmus\Cyp4a31
2 of 15
No
No
Mmus\Cyp4a32
2 of 15
No
No
Mmus\Cyp4b1
2 of 15
No
No
Mmus\Cyp4f13
2 of 15
No
No
Mmus\Cyp4f14
2 of 15
No
No
Mmus\Cyp4f15
2 of 15
No
No
Mmus\Cyp4f16
2 of 15
No
No
Mmus\Cyp4f17
2 of 15
No
No
Mmus\Cyp4f18
2 of 15
No
No
Mmus\Cyp4f37
2 of 15
No
No
Mmus\Cyp4f39
2 of 15
No
No
Mmus\Cyp4f40
2 of 15
No
No
Mmus\Cyp4x1
2 of 15
No
No
Mmus\Cyp2c67
1 of 15
No
No
Mmus\Cyp2c69
1 of 15
No
No
Mmus\Cyp3a57
1 of 15
No
No
Mmus\Cyp4a10
1 of 15
No
No
Mmus\Cyp8b1
1 of 15
No
Yes
Mmus\Cyp20a1
1 of 15
No
Yes
Mmus\Cyp26a1
1 of 15
No
No
Mmus\Cyp26b1
1 of 15
No
No
Mmus\Cyp26c1
1 of 15
No
No
Mmus\Cyp46a1
1 of 15
No
No
Rattus norvegicus (Norway rat) (29)
Rnor\Cyp4v3
5 of 13
Yes
No
Rnor\Cyp19a1
3 of 13
No
No
Rnor\Cyp4a2
2 of 13
No
No
Rnor\Cyp4a8
2 of 13
No
No
Rnor\Cyp4b1
2 of 13
No
No
Rnor\Cyp4f1
2 of 13
No
No
Rnor\Cyp4f4
2 of 13
No
No
Rnor\Cyp4f5
2 of 13
No
No
Rnor\Cyp4f6
2 of 13
No
No
Rnor\Cyp4f17
2 of 13
No
No
Rnor\Cyp4f18
2 of 13
No
No
Rnor\Cyp4f37
2 of 13
No
No
Rnor\Cyp4f39
2 of 13
No
No
Rnor\Cyp4f40
2 of 13
No
No
Rnor\Cyp3a71-ps
1 of 13
No
Yes
Rnor\Cyp4a1
1 of 13
No
No
Rnor\Cyp4a3
1 of 13
No
No
Rnor\Cyp4x1
1 of 13
No
No
Rnor\Cyp20a1
1 of 13
No
Yes
Rnor\Cyp26a1
1 of 13
No
Yes
Rnor\Cyp26b1
1 of 13
No
Yes
Rnor\Cyp26c1
1 of 13
No
Yes
Rnor\Cyp46a1
1 of 13
No
No
Rnor\LOC680316
1 of 13
No
Yes
Rnor\LOC691320
1 of 13
No
Yes
Rnor\LOC100912391
1 of 13
No
Yes
Rnor\LOC100912471
1 of 13
No
Yes
Rnor\LOC103692784
1 of 13
No
Yes
Rnor\Pdgfrb
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\cyp4v2
4 of 12
Yes
No
Xtro\cyp19a1
3 of 12
No
No
Xtro\cyp4b1.2
2 of 12
No
No
Xtro\cyp4b1
2 of 12
No
No
Xtro\cyp4f2
2 of 12
No
No
Xtro\cyp4f22
2 of 12
No
No
Xtro\LOC100487918
2 of 12
No
No
Xtro\cyp20a1
1 of 12
No
Yes
Xtro\cyp26a1
1 of 12
No
Yes
Xtro\cyp26b1
1 of 12
No
Yes
Xtro\cyp26c1
1 of 12
No
Yes
Xtro\LOC100485929
1 of 12
No
No
Xtro\LOC100487846
1 of 12
No
No
Xtro\LOC100488227
1 of 12
No
No
Xtro\LOC100488386
1 of 12
No
Yes
Xtro\mgc108213
1 of 12
No
No
Danio rerio (Zebrafish) (17)
Drer\cyp4v7
5 of 15
Yes
No
Drer\cyp4v8
5 of 15
Yes
No
Drer\cyp19a1a
3 of 15
No
No
Drer\cyp4f3
2 of 15
No
No
Drer\cyp4t8
2 of 15
No
No
Drer\cyp19a1b
2 of 15
No
Yes
Drer\cyp46a1.3
2 of 15
No
Yes
Drer\zgc:123299
2 of 15
No
Yes
Drer\cyp2j20
1 of 15
No
No
Drer\cyp2p7
1 of 15
No
No
Drer\cyp20a1
1 of 15
No
Yes
Drer\cyp26a1
1 of 15
No
No
Drer\cyp26b1
1 of 15
No
Yes
Drer\cyp26c1
1 of 15
No
Yes
Drer\cyp46a1.1
1 of 15
No
No
Drer\cyp46a1.2
1 of 15
No
No
Drer\cyp46a1.4
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\cyp-31A2
4 of 15
Yes
No
Cele\cyp-31A3
4 of 15
Yes
No
Cele\cyp-37A1
4 of 15
Yes
No
Cele\cyp-42A1
4 of 15
Yes
No
Cele\cyp-29A2
3 of 15
No
No
Cele\cyp-29A3
3 of 15
No
No
Cele\cyp-29A4
3 of 15
No
No
Cele\cyp-31A5
3 of 15
No
No
Cele\cyp-32A1
3 of 15
No
No
Cele\cyp-32B1
3 of 15
No
No
Cele\cyp-37B1
3 of 15
No
No
Cele\cyp-33C4
1 of 15
No
No
Cele\cyp-34A1
1 of 15
No
No
Cele\cyp-35A4
1 of 15
No
No
Cele\cyp-35D1
1 of 15
No
No
Cele\F23A7.3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (66)
Atha\CYP72A11
4 of 9
Yes
No
Atha\CYP72A13
4 of 9
Yes
No
Atha\CYP72A14
4 of 9
Yes
No
Atha\CYP72A15
4 of 9
Yes
No
Atha\AT5G08250
3 of 9
No
No
Atha\BAS1
3 of 9
No
No
Atha\CYP72A7
3 of 9
No
No
Atha\CYP72A8
3 of 9
No
No
Atha\CYP72A9
3 of 9
No
No
Atha\CYP72A10
3 of 9
No
No
Atha\CYP86A4
3 of 9
No
Yes
Atha\CYP86B1
3 of 9
No
No
Atha\CYP86C1
3 of 9
No
Yes
Atha\CYP86C3
3 of 9
No
Yes
Atha\CYP86C4
3 of 9
No
Yes
Atha\CYP94B1
3 of 9
No
Yes
Atha\CYP94B2
3 of 9
No
No
Atha\CYP94B3
3 of 9
No
Yes
Atha\CYP94D1
3 of 9
No
Yes
Atha\CYP94D2
3 of 9
No
Yes
Atha\CYP704A1
3 of 9
No
No
Atha\CYP704A2
3 of 9
No
No
Atha\CYP704B1
3 of 9
No
No
Atha\CYP714A1
3 of 9
No
No
Atha\CYP714A2
3 of 9
No
No
Atha\CYP715A1
3 of 9
No
No
Atha\CYP735A1
3 of 9
No
No
Atha\CYP735A2
3 of 9
No
No
Atha\CYP72C1
2 of 9
No
No
Atha\CYP86A1
2 of 9
No
No
Atha\CYP86A2
2 of 9
No
Yes
Atha\CYP86A7
2 of 9
No
No
Atha\CYP86A8
2 of 9
No
No
Atha\CYP86C2
2 of 9
No
Yes
Atha\CYP94C1
2 of 9
No
No
Atha\CYP96A1
2 of 9
No
No
Atha\CYP96A2
2 of 9
No
No
Atha\CYP96A3
2 of 9
No
No
Atha\CYP96A4
2 of 9
No
No
Atha\CYP96A5
2 of 9
No
No
Atha\CYP96A8
2 of 9
No
No
Atha\CYP96A10
2 of 9
No
No
Atha\CYP96A11
2 of 9
No
No
Atha\CYP96A12
2 of 9
No
No
Atha\CYP96A13
2 of 9
No
No
Atha\CYP96A15
2 of 9
No
No
Atha\CYP97A3
2 of 9
No
No
Atha\CYP97B3
2 of 9
No
No
Atha\CYP709B1
2 of 9
No
No
Atha\CYP709B2
2 of 9
No
No
Atha\CYP709B3
2 of 9
No
No
Atha\CYP721A1
2 of 9
No
No
Atha\LUT1
2 of 9
No
No
Atha\AT3G44970
1 of 9
No
Yes
Atha\AT5G51900
1 of 9
No
Yes
Atha\CPD
1 of 9
No
Yes
Atha\CYP71A18
1 of 9
No
No
Atha\CYP76C3
1 of 9
No
No
Atha\CYP87A2
1 of 9
No
Yes
Atha\CYP96A9
1 of 9
No
No
Atha\CYP96A14P
1 of 9
No
Yes
Atha\CYP702A1
1 of 9
No
Yes
Atha\CYP702A3
1 of 9
No
Yes
Atha\CYP702A5
1 of 9
No
Yes
Atha\CYP702A6
1 of 9
No
Yes
Atha\CYP702A8
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\ERG5
2 of 15
Yes
No
Scer\DIT2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\erg11
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919059R )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005310
Drosophila simulans
Dsim\GD24639
Drosophila erecta
Dere\GG12761
Drosophila yakuba
Dyak\GE16587
Drosophila ananassae
Dana\GF20812
Drosophila pseudoobscura pseudoobscura
Dpse\GA17813
Drosophila willistoni
Dwil\GK25658
Drosophila virilis
Dvir\GJ15981
Drosophila mojavensis
Dmoj\GI11123
Drosophila grimshawi
Dgri\GH24346
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502W7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022914
Musca domestica
House fly
Mdoa\17022917
Musca domestica
House fly
Mdoa\17025165
Musca domestica
House fly
Mdoa\17022915
Musca domestica
House fly
Mdoa\17023134
Musca domestica
House fly
Mdoa\17022916
Musca domestica
House fly
Mdoa\17022912
Glossina morsitans
Tsetse fly
Gmor\GMOY009554
Glossina morsitans
Tsetse fly
Gmor\GMOY006761
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02700
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07638
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_06026
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10552
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03675
Mayetiola destructor
Hessian fly
Mdes\Mdes010404
Mayetiola destructor
Hessian fly
Mdes\Mdes010406
Mayetiola destructor
Hessian fly
Mdes\Mdes003297
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4G35
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006824
Aedes aegypti
Yellow fever mosquito
Aaeg\CYP4G36
Anopheles darlingi
American malaria mosquito
Adar\ADAC000657
Anopheles darlingi
American malaria mosquito
Adar\ADAC004229
Anopheles gambiae
Malaria mosquito
Agam\CYP4G16
Anopheles gambiae
Malaria mosquito
Agam\CYP4G17
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018668
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03JG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\LOC100127115
Bombyx mori
Silkmoth
Bmor\BGIBMGA001005
Bombyx mori
Silkmoth
Bmor\BGIBMGA001162
Bombyx mori
Silkmoth
Bmor\BGIBMGA003683
Bombyx mori
Silkmoth
Bmor\BGIBMGA001003
Danaus plexippus
Monarch butterfly
Dple\DPOGS212789-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215623-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205654-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201061-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205157-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS215622-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211931-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008770
Heliconius melpomene
Postman butterfly
Hmel\HMEL003583
Heliconius melpomene
Postman butterfly
Hmel\HMEL005933
Heliconius melpomene
Postman butterfly
Hmel\HMEL003581
Heliconius melpomene
Postman butterfly
Hmel\HMEL005932
Heliconius melpomene
Postman butterfly
Hmel\HMEL009876
Heliconius melpomene
Postman butterfly
Hmel\HMEL003584
Heliconius melpomene
Postman butterfly
Hmel\HMEL006588
Heliconius melpomene
Postman butterfly
Hmel\HMEL002471
Heliconius melpomene
Postman butterfly
Hmel\HMEL006024
Heliconius melpomene
Postman butterfly
Hmel\HMEL016705
Heliconius melpomene
Postman butterfly
Hmel\HMEL008768
Heliconius melpomene
Postman butterfly
Hmel\HMEL010693
Heliconius melpomene
Postman butterfly
Hmel\HMEL003582
Apis florea
Little honeybee
Aflo\2262004468
Apis florea
Little honeybee
Aflo\2147749907
Apis florea
Little honeybee
Aflo\3200303956
Apis mellifera
Western honey bee
Amel\GB47270
Apis mellifera
Western honey bee
Amel\CYP4AV1
Apis mellifera
Western honey bee
Amel\GB51356
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17222
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20078
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15257
Bombus terrestris
Buff-tailed bumblebee
Bter\15208673
Bombus terrestris
Buff-tailed bumblebee
Bter\15205936
Bombus terrestris
Buff-tailed bumblebee
Bter\15212474
Linepithema humile
Argentine ant
Lhum\LH24978
Linepithema humile
Argentine ant
Lhum\LH16316
Linepithema humile
Argentine ant
Lhum\LH10682
Linepithema humile
Argentine ant
Lhum\LH22782
Linepithema humile
Argentine ant
Lhum\LH25003
Linepithema humile
Argentine ant
Lhum\LH21674
Linepithema humile
Argentine ant
Lhum\LH14939
Linepithema humile
Argentine ant
Lhum\LH22783
Linepithema humile
Argentine ant
Lhum\LH22785
Linepithema humile
Argentine ant
Lhum\LH10850
Linepithema humile
Argentine ant
Lhum\LH23345
Linepithema humile
Argentine ant
Lhum\LH22786
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d3d
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000788
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0001f1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010254
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012361
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008110
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013770
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012360
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010775
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000732
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015477
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012359
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007621
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008212
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG037124
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013401
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012056
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG020600
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003406
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009254
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008109
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008685
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012057
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019580
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005578
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003405
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004151
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00676
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06739
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07362
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04191
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01611
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00113
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05824
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07200
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00566
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00528
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03628
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03851
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03213
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01031
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05823
Tribolium castaneum
Red flour beetle
Tcas\TC015343
Tribolium castaneum
Red flour beetle
Tcas\TC033333
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07061
Tribolium castaneum
Red flour beetle
Tcas\TC010423
Tribolium castaneum
Red flour beetle
Tcas\CYP4BR3
Tribolium castaneum
Red flour beetle
Tcas\TC012503
Tribolium castaneum
Red flour beetle
Tcas\TC009412
Tribolium castaneum
Red flour beetle
Tcas\TC012498
Tribolium castaneum
Red flour beetle
Tcas\TC012501
Tribolium castaneum
Red flour beetle
Tcas\TC013681
Tribolium castaneum
Red flour beetle
Tcas\TC012662
Tribolium castaneum
Red flour beetle
Tcas\TC015292
Tribolium castaneum
Red flour beetle
Tcas\TC002722
Tribolium castaneum
Red flour beetle
Tcas\TC014125
Tribolium castaneum
Red flour beetle
Tcas\TC033050
Tribolium castaneum
Red flour beetle
Tcas\TC012500
Tribolium castaneum
Red flour beetle
Tcas\TC013679
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_08058
Tribolium castaneum
Red flour beetle
Tcas\TC034363
Tribolium castaneum
Red flour beetle
Tcas\TC033334
Tribolium castaneum
Red flour beetle
Tcas\TC015992
Tribolium castaneum
Red flour beetle
Tcas\TC015291
Tribolium castaneum
Red flour beetle
Tcas\TC033335
Tribolium castaneum
Red flour beetle
Tcas\TC012504
Tribolium castaneum
Red flour beetle
Tcas\TC012499
Tribolium castaneum
Red flour beetle
Tcas\CYP4Q7
Tribolium castaneum
Red flour beetle
Tcas\TC013680
Tribolium castaneum
Red flour beetle
Tcas\TC002721
Tribolium castaneum
Red flour beetle
Tcas\TC013773
Tribolium castaneum
Red flour beetle
Tcas\TC012495
Tribolium castaneum
Red flour beetle
Tcas\TC014641
Tribolium castaneum
Red flour beetle
Tcas\TC003368
Pediculus humanus
Human body louse
Phum\PHUM452970
Pediculus humanus
Human body louse
Phum\PHUM371380
Pediculus humanus
Human body louse
Phum\PHUM371390
Pediculus humanus
Human body louse
Phum\PHUM458480
Pediculus humanus
Human body louse
Phum\PHUM063470
Pediculus humanus
Human body louse
Phum\PHUM019500
Pediculus humanus
Human body louse
Phum\PHUM452980
Pediculus humanus
Human body louse
Phum\PHUM371370
Rhodnius prolixus
Kissing bug
Rpro\RPRC015287
Rhodnius prolixus
Kissing bug
Rpro\RPRC004769
Rhodnius prolixus
Kissing bug
Rpro\RPRC000027
Rhodnius prolixus
Kissing bug
Rpro\RPRC004731
Rhodnius prolixus
Kissing bug
Rpro\RPRC000196
Rhodnius prolixus
Kissing bug
Rpro\RPRC015286
Rhodnius prolixus
Kissing bug
Rpro\RPRC003227
Rhodnius prolixus
Kissing bug
Rpro\RPRC004766
Rhodnius prolixus
Kissing bug
Rpro\RPRC013847
Rhodnius prolixus
Kissing bug
Rpro\RPRC004758
Rhodnius prolixus
Kissing bug
Rpro\RPRC004733
Cimex lectularius
Bed bug
Clec\CLEC005851
Cimex lectularius
Bed bug
Clec\CLEC005721
Cimex lectularius
Bed bug
Clec\CLEC004796
Cimex lectularius
Bed bug
Clec\CLEC007341
Cimex lectularius
Bed bug
Clec\CLEC012067
Cimex lectularius
Bed bug
Clec\CLEC025147
Cimex lectularius
Bed bug
Clec\CLEC013923
Cimex lectularius
Bed bug
Clec\CLEC007343
Cimex lectularius
Bed bug
Clec\CLEC005850
Cimex lectularius
Bed bug
Clec\CLEC005720
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007609
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI56605
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000176
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI44407
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001913
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005733
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005113
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002628
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI085487
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003803
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI069651
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05398
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09478
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13889
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09480
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05391
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08930
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05390
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_16223
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09481
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_14590
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03222
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03G3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008771
Strigamia maritima
European centipede
Smar\SMAR008770
Strigamia maritima
European centipede
Smar\SMAR005769
Strigamia maritima
European centipede
Smar\SMAR008807
Strigamia maritima
European centipede
Smar\SMAR008806
Strigamia maritima
European centipede
Smar\SMAR012322
Strigamia maritima
European centipede
Smar\SMAR008774
Ixodes scapularis
Black-legged tick
Isca\ISCW022703
Ixodes scapularis
Black-legged tick
Isca\ISCW022704
Ixodes scapularis
Black-legged tick
Isca\ISCW022706
Ixodes scapularis
Black-legged tick
Isca\ISCW022705
Ixodes scapularis
Black-legged tick
Isca\ISCW013762
Ixodes scapularis
Black-legged tick
Isca\ISCW022699
Ixodes scapularis
Black-legged tick
Isca\ISCW003279
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80254.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74841.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58190.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65253.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62443.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75827.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM65323.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61188.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63207.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g00650
Tetranychus urticae
Two-spotted spider mite
Turt\tetur36g00920
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g03800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311383
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305575
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305713
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311767
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311594
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_340592
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_221284
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42067
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_309254
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_329890
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311385
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305686
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_235307
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_192258
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42144
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312044
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303449
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_96133
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311475
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311593
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311387
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_50258
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311388
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42950
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311394
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_306533
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_320218
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312048
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311596
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311474
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_206765
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42254
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311386
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311473
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G06KN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4L2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cyp4VL6
Ciona intestinalis
Vase tunicate
Cint\LOC100179192
Ciona intestinalis
Vase tunicate
Cint\LOC100180750
Ciona intestinalis
Vase tunicate
Cint\LOC100187185
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000012965
Ciona intestinalis
Vase tunicate
Cint\LOC100183395
Ciona intestinalis
Vase tunicate
Cint\LOC100186171
Ciona intestinalis
Vase tunicate
Cint\LOC100181903
Ciona intestinalis
Vase tunicate
Cint\LOC100175798
Ciona intestinalis
Vase tunicate
Cint\LOC100181326
Gallus gallus
Domestic chicken
Ggal\CYP4V2
Gallus gallus
Domestic chicken
Ggal\LOC771974
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026611
Gallus gallus
Domestic chicken
Ggal\CYP4B1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (37)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Cyp4g15
5 of 10
Cyp4ac1
4 of 10
Cyp4ac2
4 of 10
Cyp4ac3
4 of 10
Cyp4ad1
4 of 10
Cyp4ae1
4 of 10
Cyp4c3
4 of 10
Cyp4d1
4 of 10
Cyp4d2
4 of 10
Cyp4d8
4 of 10
Cyp4d14
4 of 10
Cyp4d20
4 of 10
Cyp4e1
4 of 10
Cyp4e2
4 of 10
Cyp4e3
4 of 10
Cyp4p1
4 of 10
Cyp4p2
4 of 10
Cyp4p3
4 of 10
Cyp4s3
4 of 10
Cyp316a1
4 of 10
Cyp4aa1
3 of 10
Cyp4d21
3 of 10
Cyp311a1
3 of 10
Cyp312a1
3 of 10
Cyp313b1
3 of 10
Cyp313a1
2 of 10
Cyp313a2
2 of 10
Cyp313a3
2 of 10
Cyp313a4
2 of 10
Cyp313a5
2 of 10
Cyp318a1
2 of 10
Cyp6a8
1 of 10
Cyp6a23
1 of 10
Cyp6t1
1 of 10
Cyp6t3
1 of 10
Cyp309a2
1 of 10
sad
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CYP4V2; cytochrome P450 family 4 subfamily V member 2
    5 of 15
    608614
    CYP19A1; cytochrome P450 family 19 subfamily A member 1
    3 of 15
    107910
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Interactions Browser
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map

    1-0

    Cytogenetic map
    1B4-1B4
    Sequence location
    X:467,057..469,335 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    1B4-1B4
    Limits computationally determined from genome sequence between P{EP}CG17896EP1320&P{EP}EP1398 and P{EP}svrEP356&P{EP}argEP452
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    1B-1B
    (Dunkov, 2000.6.29, Feyereisen and Dunkov, 1995.11.2)
    1B1-1B1
    (determined by in situ hybridisation)
    (Maitra et al., 1996)
    1B-1B
    (determined by in situ hybridisation)
    (Dunkov et al., 1996)
    Experimentally Determined Recombination Data
    Location

    1-0

    (FlyBase, 2016)

    1-0.0

    (Comeron et al., 2012)

    1-

    (Feyereisen and Dunkov, 1995.11.2)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (5)
    Genomic Clones (8)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (324)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      monoclonal

      (Sundseth et al., 1989)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of

      Source for merge of: Cyp4g1 anon-WO0140519.102

      (FlyBase, 1996-)
      Additional comments

      The Cyp4g1 gene may have been derived from the Cyp4ac1 gene by retroposition.

      (Pan and Zhang, 2009)

      Source for merge of Cyp4g1 anon-WO0140519.102 was sequence comparison ( date:051113 ).

      (FlyBase, 1996-)
      Other Comments

      The intronless Cyp4g1 gene is not a retrogene, as shown by the conserved synteny from Diptera to at least Hymenoptera.

      (Feyereisen, 2020)

      Identified molecularly using degenerate PCR primers designed from conserved regions of known insect P450 genes.

      (Dunkov et al., 1996)

      Corresponds to cytochrome P450 A1 cDNA of FBrf0057534.

      (Feyereisen and Dunkov, 1995.11.2)

      The adenylate cyclase inactivator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin inhibit, in a dose-dependent fashion, the ecdysone 20-monooxygenase activity associated with wandering stage larvae.

      (Keogh et al., 1992)

      Purification of Cyp4g1 and Cyp6a2 using techniques traditionally used for mammalian P-450.

      (Sundseth et al., 1990)

      Transcription unit defined during molecular analysis of the achaete-scute complex.

      (Alonso and Cabrera, 1988)

      Visualised as 59.3kD band on electrophoresis. Ubiquitous in all strains, irrespective of resistance to insecticides (Sundseth, Kennel and Waters, 1989). Monoclonal antibodies raised by Sundseth, Kennel and Waters (1989).

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 36 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (21)
      Reported As
      Symbol Synonym
      4g1
      (Nelson, 2001.2.5)
      ASC-T1
      (Gomez-Skarmeta et al., 1995, Romani, 1994.12.12)
      CG3972
      (Çiçek et al., 2016, Cammarato et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Benos, 2000.12.13)
      CYP4G1
      (Feyereisen, 2020, Qiu et al., 2012)
      Cyp4g1
      (Parker et al., 2020, Scanlan et al., 2020, Wang et al., 2020, Maitra et al., 2019, Pardy et al., 2019, Zhang and Zhang, 2019, Seong et al., 2018, Christesen et al., 2017, Stefana et al., 2017, Cinnamon et al., 2016, Ou et al., 2016, Gellatly et al., 2015, Steele et al., 2015, dos Santos, 2014, Gendrin et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Sztal et al., 2012, Niwa et al., 2011, Kühnlein, 2010, Allen and Spradling, 2008, Wang et al., 2008, Gutierrez et al., 2007, Parisi et al., 2004)
      Cyt-P450-A1
      EG:165H7.1
      (Benos et al., 2001, Benos, 2000.12.13)
      P-450
      (Danielson et al., 1995)
      P-450-A
      (Sundseth et al., 1990, Waters and Nix, 1988)
      P450
      (Arking, 1998, Zakharenko and Zakharov, 1998, Frolich and Wurgler, 1991)
      P450-A
      (Sundseth et al., 1989)
      P450A
      (Brodu et al., 2004)
      T1
      (Long et al., 2000, Modolell and Campuzano, 1998, Campuzano and Modolell, 1992, Alonso and Cabrera, 1988, Campuzano et al., 1985)
      anon-WO0140519.102
      cyp4g1
      (Sharma et al., 2011, Al-Anzi et al., 2009)
      scγ
      (Long et al., 2000)
      Name Synonyms
      Achaete-scute Complex transcript 1
      Cytochrome P450 4g1
      (Pedersen et al., 2010)
      Cytochrome P450 A1
      Cytochrome P450-4g1
      (Zhan et al., 2013, Cammarato et al., 2011, Kühnlein, 2010)
      cytochrome P450
      (Chung et al., 2009)
      Secondary FlyBase IDs
      • FBgn0011757
      • FBgn0023539
      • FBgn0044782
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (100)