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Gene Dmel\Itp-r83A

General Information
Symbol	Dmel\Itp-r83A	Species	D. melanogaster
Name	Inositol 1,4,5,-tris-phosphate receptor	Annotation symbol	CG1063
Feature type	protein_coding_gene	FlyBase ID	FBgn0010051
Gene Model Status	Current	Stock availability	17 publicly available
Also Known As	itpr, IP3R, InsP3R, dip, IP3R, InsP3, l(3)itpr
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83A7-83B1	Sequence location	3R:1,342,862..1,364,584 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Inositol 1,4,5,-tris-phosphate receptor is referred to in FlyBase by the symbol Dmel\Itp-r83A (CG1063, FBgn0010051). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. There is experimental evidence that it is involved in the biological process: larval feeding behavior; cellular calcium ion homeostasis; stabilization of membrane potential; response to oxidative stress; nuclear division; flight behavior; molting cycle, chitin-based cuticle; mushroom body development; release of sequestered calcium ion into cytosol; sensory perception of taste. 42 alleles are reported. The phenotypes of these alleles are annotated with: dorsal medial muscle; mushroom body; wing margin; mesothoracic tergum; wing; antennal lobe; indirect flight muscle. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Inositol 1,4,5-trisphosphate-binding protein receptor; Inositol 1,4,5-trisphosphate/ryanodine receptor; Intracellular calcium-release channel; Ion transport; MIR; MIR motif; RyR/IP3R Homology associated domain; Ryanodine receptor-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult crop, adult fat body, adult salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1639461_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Itp-r83A. Gene sequence location is 3R:1342862..1364584.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Controlled Vocabulary Terms day 1 of adulthood perinuclear endoplasmic reticulum retina References Murmu et al., 2011, BMC Neurosci. 12: 105 Sequence features BKN20722 HFA12354
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83A7-83B1   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 42B1-42B2     (Hasan, 1992.11.20) 83A5-83A6   (determined by in situ hybridisation)   (Spradling et al., 1999) 83A5-83A9   (determined by in situ hybridisation)   (Hasan, 1998) 83A5-83A6     (BDGP Project Members, 1994-1999) 83A5-83A9   (determined by in situ hybridisation)   (Yoshikawa et al., 1992) 83A5-83A9   (determined by in situ hybridisation)   (Hasan and Rosbash, 1992)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Itp-r83A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Pairs of compensatory frame shifts in middle of eleventh and seventeenth exon cause mismatches with SWP:P29993.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Itp-r83A-RA FBtr0078686  NM_169061   9687   2828 Itp-r83A-RB FBtr0078687  NM_169060   8965   2837
Additional Transcript Data & Comments
Reported size (kB)	10 (unknown) (Yoshikawa et al., 1992) 10.5 (compiled cDNA) (Sinha and Hasan, 1999) 10.0, 9.7 (northern blot) (Hasan and Rosbash, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Itp-r83A-PA   FBpp0078335   318.2   2828   5.81     NP_730942   AAF52015 Itp-r83A-PB   FBpp0078336   319.1   2837   5.70     NP_730941   AAN13240
Additional Polypeptide Data & Comments
Reported size (kDa)	2833 (aa); 319 (kD) (Yoshikawa et al., 1992) 2828 (aa) (Sinha and Hasan, 1999) 469 (aa) (Hasan and Rosbash, 1992)
Comments	The Itp-r83A protein was functionally expressed in NG108-15 cells where it was shown to specifically bind Ins-1,4,5-P3. (Yoshikawa et al., 1992)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Inositol 1,4,5-trisphosphate-binding protein receptor (IPR000493) Intracellular calcium-release channel (IPR000699) MIR (IPR003608) Ion transport (IPR005821) RyR/IP3R Homology associated domain (IPR013662) Ryanodine receptor-related (IPR015925) Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821) MIR motif (IPR016093)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF52015   AE014297 AAN13240   AJ238949 CAB51853   AQ034066   AX664475   BZ748900   BZ748901   CO189200   CO294537   CO316126   CO337145   CZ472543   CZ472544   D90403 BAA14399   EC075304   EC087803   EC203542   EC206838   EC225801   EC266077   Z18535 CAA79220
UniProtKB/Swiss-Prot	P29993
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13   epidermis | lateral   (Hasan and Rosbash, 1992) embryonic stage 15   head | anterior   (Hasan and Rosbash, 1992) adult stage   leg   (Hasan and Rosbash, 1992) adult brain   (Hasan and Rosbash, 1992) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval labial organ   (Hasan and Rosbash, 1992) embryonic stage 14   labral segment   (Hasan and Rosbash, 1992) adult stage   eye   (Hasan and Rosbash, 1992) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Hasan and Rosbash, 1992) adult stage   antenna   (Hasan and Rosbash, 1992)
Additional Descriptive Data
	Itp-r83A transcripts are expressed throughout development. Highest levels in adults are in fractions containing appendages (legs, antennae, wings, seta). Strong expression in the retina, antenna, legs and thorax was deduced. (Yoshikawa et al., 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage   photoreceptor cell   (Hasan and Rosbash, 1992) adult brain   (Hasan and Rosbash, 1992) antenna   (Hasan and Rosbash, 1992) immunohistochemistry Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval salivary gland   (Venkatesh and Hasan, 1997) ring gland   (Venkatesh and Hasan, 1997) myoblast of imaginal disc   (Venkatesh and Hasan, 1997) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 9   mesoderm   (Raghu and Hasan, 1995) embryonic stage 9 -- 17   head mesoderm   (Raghu and Hasan, 1995) embryonic stage 13   cardioblast   (Raghu and Hasan, 1995) somatic mesoderm   (Raghu and Hasan, 1995) pharyngeal muscle   (Raghu and Hasan, 1995) visceral mesoderm   (Raghu and Hasan, 1995) third instar larval stage   eye disc   (Raghu and Hasan, 1995) myoblast of ventral thoracic disc   (Raghu and Hasan, 1995) myoblast of wing disc   (Raghu and Hasan, 1995) morphogenetic furrow | posterior to   (Raghu and Hasan, 1995) pupal stage | late   second antennal segment muscle   (Raghu and Hasan, 1995) pupal stage   dorsal medial muscle   (Raghu and Hasan, 1995) myoblast   (Raghu and Hasan, 1995) adult stage   antennal segment 3 sensillum   (Raghu and Hasan, 1995) photoreceptor cell   (Raghu and Hasan, 1995) cone cell   (Raghu and Hasan, 1995) olfactory sensory organ   (Raghu and Hasan, 1995) proboscis   (Raghu and Hasan, 1995) antennal segment 2 sense organ   (Raghu and Hasan, 1995) pigment cell   (Raghu and Hasan, 1995) maxillary palp sense organ   (Raghu and Hasan, 1995) day 1 of adulthood   photoreceptor cell   • perinuclear endoplasmic reticulum (Raghu et al., 2000) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   head   • microsome (Srikanth et al., 2004) day 1 of adulthood   retina   (Raghu et al., 2000)
Additional Descriptive Data
	Itp-r83A protein is detected in the second and third antennal segments as well as in the proboscis and the maxillary palps. In these locations, it is loclaized to the base of sensory hairs used for taste or olfaction. In the brain, it is restricted to cell bodies and is probably perinuclear. Itp-r83A protein is observed associated with nuclei of each photoreceptor, cone and pigment cell. It is also present in the muscles of the head. In embryos, Itp-r83A protein is observed in mesoderm. Protein is first observed at stage 9 and reaches a maximum in stage 13. It is present in somatic and visceral mesoderm and in two rows of cardioblasts along the dorsal midline. Staining begins to fade by stage 14. In the cephalic region, protein is observed in the procephalic mesoderm starting at stage 9 and is present in pharyngeal muscle by stage 13. In third instar larvae, Itp-r83A protein is found in myoblasts in the wing and leg discs. In the eye disc, staining is associated with photoreceptor cells just behind the morphogenetic furrow. In pupae, Itp-r83A protein was examined in the development of the DLMs. It is expressed in the myoblasts in the region of the DLMs and later in the fused myoblasts, and later still in the developing muscle fibres. Itp-r83A protein is found to be expressed also in antennal muscles during their development. (Raghu and Hasan, 1995)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0010051    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0010051 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0010051 expression level Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr    1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (701) embryo 02-04hr  (211) embryo 04-06hr  (376) embryo 06-08hr  (651) embryo 08-10hr  (719) embryo 10-12hr  (797) embryo 12-14hr  (1506) embryo 14-16hr  (1259) embryo 16-18hr  (1083) embryo 18-20hr  (941) embryo 20-22hr  (822) embryo 22-24hr  (916) larva L1  (836) larva L2  (722) larva L3 12hr old  (566) larva L3 puffstage 1-2  (455) larva L3 puffstage 3-6  (705) larva L3 puffstage 7-9  (595) white prepupae new  (872) white prepupae 12hr  (548) white prepupae 24hr  (649) pupae 2d postWPP  (1106) pupae 3d postWPP  (600) pupae 4d postWPP  (600) adult male 01day  (656) adult male 05day  (676) adult male 30day  (637) adult female 01day  (696) adult female 05day  (840) adult female 30day  (828) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr  1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr    1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr    1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0010051 expression level Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr    1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (701) embryo 02-04hr  (211) embryo 04-06hr  (376) embryo 06-08hr  (651) embryo 08-10hr  (719) embryo 10-12hr  (797) embryo 12-14hr  (1506) embryo 14-16hr  (1259) embryo 16-18hr  (1083) embryo 18-20hr  (941) embryo 20-22hr  (822) embryo 22-24hr  (916) larva L1  (836) larva L2  (722) larva L3 12hr old  (566) larva L3 puffstage 1-2  (455) larva L3 puffstage 3-6  (705) larva L3 puffstage 7-9  (595) white prepupae new  (872) white prepupae 12hr  (548) white prepupae 24hr  (649) pupae 2d postWPP  (1106) pupae 3d postWPP  (600) pupae 4d postWPP  (600) adult male 01day  (656) adult male 05day  (676) adult male 30day  (637) adult female 01day  (696) adult female 05day  (840) adult female 30day  (828) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr  1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr    1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    701 embryo 02-04hr    211 embryo 04-06hr    376 embryo 06-08hr    651 embryo 08-10hr    719 embryo 10-12hr    797 embryo 12-14hr    1506 embryo 14-16hr    1259 embryo 16-18hr    1083 embryo 18-20hr    941 embryo 20-22hr    822 embryo 22-24hr    916 larva L1    836 larva L2    722 larva L3 12hr old    566 larva L3 puffstage 1-2    455 larva L3 puffstage 3-6    705 larva L3 puffstage 7-9    595 white prepupae new    872 white prepupae 12hr    548 white prepupae 24hr    649 pupae 2d postWPP    1106 pupae 3d postWPP    600 pupae 4d postWPP    600 adult male 01day    656 adult male 05day    676 adult male 30day    637 adult female 01day    696 adult female 05day    840 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0010051    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0010051 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, adult crop, adult fat body, adult salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0010051 expression level Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0010051 expression level Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    36.275 Larval Midgut    38.1 Larval Hindgut    50.9 Larval Malpighian Tubules    42.3 Larval Fat Body    86.2 Larval Salivary Gland    90.8 Larval Trachea    78.65 Larval Carcass    52.425 Adult Head    61.5 Adult Eye    42.9 Adult Brain    106.9 Adult Thoracic-Abdominal Ganglion    84.5 Adult Crop    108.7 Adult Midgut    47.6 Adult Hindgut    72.4 Adult Malpighian Tubules    26.5 Adult Fat Body    162 Adult Salivary Gland    120.1 Adult Heart    76.725 Adult VirginFemale Spermatheca    29.8 Adult InseminatedFemale Spermatheca    33 Adult Ovary    42 Adult Testis    7.6 Adult Male Accessory Gland    29.8 Adult Carcass    71 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    61.5   NA  Eye    42.9   NA  Brain    106.9   36.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    84.5   NA  Crop    108.7   38.1  Midgut    47.6   50.9  Hindgut    72.4   42.3  Malpighian Tubules    26.5   86.2  Fat Body    162   90.8  Salivary Gland    120.1   NA  Heart    76.725   78.65  Trachea    NA   NA  VirginFemale Spermatheca    29.8   NA  InseminatedFemale Spermatheca    33   NA  Ovary    42   NA  Testis    7.6   NA  Male Accessory Gland    29.8   52.425  Carcass    71 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010051 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1063-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | cold sensitive (with Itp-r83Aka1091) Itp-r83Aug3 lethal | cold sensitive (with Itp-r83Asa54) Itp-r83Aug3 lethal | cold sensitive (with Itp-r83Aug3) Itp-r83Aka1091 Itp-r83Asa54 Itp-r83Awc703 lethal | cold sensitive (with Itp-r83Awc703) Itp-r83Aug3 lethal | larval stage Itp-r83A90B.0 Itp-r83AB4 lethal | larval stage (with Itp-r83Asv35) Itp-r83Aug3 lethal | larval stage (with Itp-r83Aug3) Itp-r83Asv35 lethal | larval stage | cold sensitive (with Itp-r83Aka1091) Itp-r83Aug3 lethal | larval stage | cold sensitive (with Itp-r83Aug3) Itp-r83Aka1091 lethal | larval stage | maternal effect | recessive Itp-r83A1 lethal | larval stage | recessive Itp-r83A90B.0 Itp-r83AB4 Itp-r83Aj5B4 lethal | partially (with Itp-r83Asa54) Itp-r83Awc361 lethal | partially (with Itp-r83Aug3) Itp-r83Awc361 lethal | partially (with Itp-r83Awc361) Itp-r83Asa54 Itp-r83Aug3 lethal | partially | cold sensitive (with Itp-r83Aka901) Itp-r83Awc361 lethal | partially | cold sensitive (with Itp-r83Awc361) Itp-r83Aka901 Itp-r83Awc703 lethal | partially | cold sensitive (with Itp-r83Awc703) Itp-r83Awc361 lethal | pupal stage (with Itp-r83A90B.0) Itp-r83A05616 lethal | pupal stage (with Itp-r83A05616) Itp-r83A90B.0 lethal | pupal stage | recessive Itp-r83A05616 lethal | recessive Itp-r83A05616 Itp-r83Aj5B4 Itp-r83Aka1091 Itp-r83Asa54 Itp-r83Aug3 Itp-r83Awc361 Itp-r83Awc703 Itp-r83AXR12 lethal | third instar larval stage, with Scer\GAL4Act5C.PI Itp-r83ANIG.1063R semi-lethal | P-stage, with Scer\GAL4elav-C155 Itp-r83ANIG.1063R viable Itp-r83A05616 Itp-r83AX7A viable, with Itp-r83Aka901/Itp-r83Aug3, Scer\GAL4arm.PS Itp-r83AScer\UAS.cVa viable, with Scer\GAL4pnr-MD237 Itp-r83AGD1676 viable (with Itp-r83Aka901), with Itp-r83AScer\UAS.cVa, Scer\GAL4arm.PS Itp-r83Aug3 viable (with Itp-r83Aug3) Itp-r83Awc361 viable (with Itp-r83Aug3), with Itp-r83AScer\UAS.cVa, Scer\GAL4arm.PS Itp-r83Aka901 viable (with Itp-r83Awc361) Itp-r83Aug3 Itp-r83Awc703 viable (with Itp-r83Awc703) Itp-r83Awc361 Sterility Allele fertile | poor (with Itp-r83Aka1091) Itp-r83Aug3 fertile | poor (with Itp-r83Aug3) Itp-r83Aka1091 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Itp-r83AGD1676 body size defective, with Itp-r83Asv35/Itp-r83Aug3, Scer\GAL4Ddc.PL Itp-r83AScer\UAS.cVa body size defective, with Itp-r83Asv35/Itp-r83Aug3, Scer\GAL4Ilp2.PR Itp-r83AScer\UAS.cVa body size defective (with Itp-r83Asv35), with Itp-r83AScer\UAS.cVa, Scer\GAL4Ddc.PL Itp-r83Aug3 body size defective (with Itp-r83Asv35), with Itp-r83AScer\UAS.cVa, Scer\GAL4Ilp2.PR Itp-r83Aug3 body size defective (with Itp-r83Aug3), with Itp-r83AScer\UAS.cVa, Scer\GAL4Ddc.PL Itp-r83Asv35 body size defective (with Itp-r83Aug3), with Itp-r83AScer\UAS.cVa, Scer\GAL4Ilp2.PR Itp-r83Asv35 body size defective | larval stage, with Scer\GAL4Act5C.PI Itp-r83ANIG.1063R body size defective | third instar larval stage (with Itp-r83Asv35) Itp-r83Aug3 body size defective | third instar larval stage (with Itp-r83Aug3) Itp-r83Asv35 chemical resistant | dominant Itp-r83A90B.0 developmental rate defective | cold sensitive (with Itp-r83Aka1091) Itp-r83Aug3 developmental rate defective | cold sensitive (with Itp-r83Aug3) Itp-r83Aka1091 developmental rate defective | recessive Itp-r83A90B.0 Itp-r83A1664GAL4 Itp-r83A05616 feeding behavior defective, with Scer\GAL4Gr5a.853 Itp-r83AdsRNA.IR.Scer\UAS feeding behavior defective | third instar larval stage (with Itp-r83Asv35) Itp-r83Aug3 feeding behavior defective | third instar larval stage (with Itp-r83Aug3) Itp-r83Asv35 flight defective, with Scer\GAL4elav-C155 Itp-r83ANIG.1063R flight defective (with Itp-r83Aka1091) Itp-r83Aug3 Itp-r83Awc361 flight defective (with Itp-r83Asa54) Itp-r83Awc361 flight defective (with Itp-r83Aug3) Itp-r83Aka1091 flight defective (with Itp-r83Awc361) Itp-r83Aka1091 Itp-r83Asa54 Itp-r83Awc703 flight defective (with Itp-r83Awc703) Itp-r83Awc361 flightless (with Itp-r83Aka1091) Itp-r83Aug3 flightless (with Itp-r83Asa54) Itp-r83Aug3 flightless (with Itp-r83Aug3) Itp-r83Aka1091 Itp-r83Asa54 Itp-r83Awc361 Itp-r83Awc703 flightless (with Itp-r83Awc361) Itp-r83Aug3 flightless (with Itp-r83Awc703) Itp-r83Aug3 flightless | partially (with Itp-r83Aka1091) Itp-r83Aug3 flightless | partially (with Itp-r83Aug3) Itp-r83Aka1091 flightless | partially (with Itp-r83Awc361) Itp-r83Awc703 flightless | partially (with Itp-r83Awc703) Itp-r83Awc361 neuroanatomy defective, with Scer\GAL4ey-OK107 Itp-r83AdsRNA.Scer\UAS neurophysiology defective, with Scer\GAL4Ddc.PL Itp-r83ANIG.1063R neurophysiology defective, with Scer\GAL4elav-C155 Itp-r83ANIG.1063R neurophysiology defective, with Scer\GAL4Ilp2.PR Itp-r83ANIG.1063R neurophysiology defective (with Itp-r83Aka1091) Itp-r83Aug3 neurophysiology defective (with Itp-r83Aug3) Itp-r83Aka1091 Itp-r83Awc703 neurophysiology defective (with Itp-r83Awc703) Itp-r83Aug3 visible (with Itp-r83Aka1091) Itp-r83Aug3 visible (with Itp-r83Asa54) Itp-r83Aug3 visible (with Itp-r83Aug3) Itp-r83Aka1091 Itp-r83Asa54 Itp-r83Awc703 visible (with Itp-r83Awc703) Itp-r83Aug3 wild-type Itp-r83A+t20 Itp-r83A+tCosmidA Phenotype manifest in Allele antennal lobe, with Scer\GAL4ey-OK107 Itp-r83AdsRNA.Scer\UAS dorsal medial muscle (with Itp-r83Aka1091) Itp-r83Aug3 dorsal medial muscle (with Itp-r83Aug3) Itp-r83Aka1091 embryonic/larval fat body | third instar larval stage (with Itp-r83Asv35) Itp-r83Aug3 embryonic/larval fat body | third instar larval stage (with Itp-r83Aug3) Itp-r83Asv35 embryonic/larval salivary gland | embryonic stage | maternal effect Itp-r83A1 eye photoreceptor cell | somatic clone Itp-r83A90B.0 imaginal disc | larval stage | maternal effect Itp-r83A1 indirect flight muscle (with Itp-r83Aka1091) Itp-r83Aug3 indirect flight muscle (with Itp-r83Aug3) Itp-r83Aka1091 Itp-r83Awc703 indirect flight muscle (with Itp-r83Awc703) Itp-r83Aug3 interommatidial bristle | somatic clone Itp-r83A90B.0 Itp-r83AB4 mesothoracic tergum, with Scer\GAL4pnr-MD237 Itp-r83AGD1676 midgut primordium | maternal effect Itp-r83A1 mushroom body, with Scer\GAL4ey-OK107 Itp-r83AdsRNA.Scer\UAS neuroblast | larval stage | maternal effect Itp-r83A1 ommatidium | maternal effect | somatic clone Itp-r83A1 principal midgut epithelial cell | maternal effect Itp-r83A1 rhabdomere | somatic clone Itp-r83A90B.0 wing, with Scer\GAL4elav-C155 Itp-r83ANIG.1063R wing (with Itp-r83Aka1091) Itp-r83Aug3 wing (with Itp-r83Aug3) Itp-r83Aka1091 Itp-r83Awc703 wing (with Itp-r83Awc703) Itp-r83Aug3 wing margin (with Itp-r83Asa54) Itp-r83Aug3 wing margin (with Itp-r83Aug3) Itp-r83Asa54
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of Itp-r83A Class Mutagen Stocks Known lesion Itp-r83A05616 hypomorphic allele - genetic evidence P-element activity 1 Yes Itp-r83A90B.0 loss of function allele P-element activity 1 Yes Itp-r83ACB-0011-3 1 -- Itp-r83Ad01974 P-element activity 1 -- Itp-r83AEY02522 P-element activity 1 -- Itp-r83Af03103 1 -- Itp-r83Aka1091 ethyl methanesulfonate 1 Yes Itp-r83Aka901 ethyl methanesulfonate 1 Yes Itp-r83AMB03611 1 -- Itp-r83ANP0921 1 -- Itp-r83Asv35 ethyl methanesulfonate 1 Yes Itp-r83Aug3 ethyl methanesulfonate 1 Yes Itp-r83A1664GAL4 Delta2-3 gene conversion 0 Yes Itp-r83A1 Delta2-3 0 Yes Itp-r83AB4 hypomorphic allele - genetic evidence P-element activity 0 Yes Itp-r83Ahc1 ethyl methanesulfonate 0 -- Itp-r83Ahc7 ethyl methanesulfonate 0 -- Itp-r83Aj5B4 P-element activity 0 Yes Itp-r83Aka904 ethyl methanesulfonate 0 -- Itp-r83Akv862 ethyl methanesulfonate 0 -- Itp-r83AL2262b P-element activity 0 -- Itp-r83AMI01796 0 -- Itp-r83Asa54 ethyl methanesulfonate 0 Yes Itp-r83Asv273 ethyl methanesulfonate 0 -- Itp-r83Asv520 ethyl methanesulfonate 0 -- Itp-r83Aug4 ethyl methanesulfonate 0 -- Itp-r83Awc361 ethyl methanesulfonate 0 Yes Itp-r83Awc703 antimorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Itp-r83AX7A P-element activity 0 Yes Itp-r83AXR12 hypomorphic allele - genetic evidence X ray 0 Yes
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Itp-r83A Class Mutagen Stocks Known lesion Itp-r83AGD1676 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Itp-r83AJF01957 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Itp-r83AKK100626 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Itp-r83AScer\UAS.cVa in vitro construct - regulatory fusion 1 Yes Itp-r83A+t20 in vitro construct - genomic fragment 0 Yes Itp-r83A+tCosmidA in vitro construct - genomic fragment 0 Yes Itp-r83AdsRNA.IR.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Itp-r83AdsRNA.Scer\UAS 0 Yes Itp-r83ANIG.1063R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Itp-r83At6 in vitro construct - genomic fragment 0 Yes Itp-r83AtCosmidB in vitro construct - genomic fragment 0 Yes Itp-r83AtCosmidC in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(3R)2-2 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(3R)BSC179 (Christensen et al., 2007.3.22) Df(3R)Exel6144 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1676} NA P{KK100626} NA P{TRiP.JF01957} NA P{UAS-Itp-r83A.dsRNA} NA P{UAS-Itp-r83A.V} NA P{UAS-Itp-r83A-RNAi} NA characterization construct P{83A.A} NA P{83A.B} NA P{83A.C} NA P{Itp-r83A+t20} NA P{Itp-r83At6} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Itp-r83Aj5B4 No P{lacW}Itp-r83AL2262b No P{lacZ}Itp-r83AB4 No P{PZ}Itp-r83A05616 No insertion of enhancer trap binary system Mi{ET1}Itp-r83AMB03611 No P{GAL4}Itp-r83A1664GAL4 No P{GawB}Itp-r83ANP0921 No miscellaneous insertions Mi{MIC}Itp-r83AMI01796 NA P{RS3}Itp-r83ACB-0011-3 NA PBac{WH}Itp-r83Af03103 NA insertion of mobile activating element P{EPgy2}Itp-r83AEY02522 NA P{XP}Itp-r83Ad01974 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inferred from direct assay (Yoshikawa et al., 1992)
Biological Process
CV term Evidence References
cellular calcium ion homeostasis inferred from mutant phenotype (Agrawal et al., 2010) flight behavior inferred from mutant phenotype (Banerjee et al., 2004, Banerjee et al., 2006) larval feeding behavior inferred from mutant phenotype (Agrawal et al., 2009) molting cycle, chitin-based cuticle inferred from genetic interaction with rut (Venkatesh et al., 2001) mushroom body development inferred from mutant phenotype (Kobayashi et al., 2006) nuclear division inferred from direct assay (Parry et al., 2005) release of sequestered calcium ion into cytosol inferred from mutant phenotype (Banerjee et al., 2006) response to oxidative stress inferred from mutant phenotype (Monnier et al., 2002) sensory perception of taste inferred from direct assay (Usui-Aoki et al., 2005) stabilization of membrane potential inferred from genetic interaction with Gα49B (Banerjee et al., 2006)
Cellular Component
CV term Evidence References
endoplasmic reticulum inferred from direct assay (Raghu et al., 2000)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
calcium channel activity non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity inferred from sequence or structural similarity with mouse Itpr1 (FlyBase, 1992-) non-traceable author statement (Hasan, 1992.11.20)
Biological Process
CV term Evidence References
calcium ion transmembrane transport inferred from electronic annotation with InterPro:IPR000699 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
endoplasmic reticulum membrane non-traceable author statement (Swiss-Prot Project Members, 1993.4.1) membrane inferred from electronic annotation with InterPro:IPR000493, InterPro:IPR000699, InterPro:IPR003608, InterPro:IPR005821, InterPro:IPR016093 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Itp-r83A allele Gene References Itp-r83A90B.0 Pka-R1 (Venkatesh et al., 2001) rut (Venkatesh et al., 2001) Itp-r83A1664GAL4 Pka-R1 (Venkatesh et al., 2001) Itp-r83A05616 Pka-R1 (Venkatesh et al., 2001) rut (Venkatesh et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65871 DroID - A comprehensive database of gene and protein interactions. • FBgn0010051 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40664
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17257 Dere\GG12871 Dgri\GH18600 Dmoj\GI23082 Dpse\GA10452 Dsim\GD19791 Dvir\GJ22702 Dwil\GK15332 Dyak\GE25474
Curated drosophilid orthologs	Dpse\GA10452
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL014637-PA Aedes aegypti (mosquito) AGAP006475-PA Anopheles gambiae (mosquito) XP_392236.3 Apis mellifera (honey bee) XP_001947344.1 Acyrthosiphon pisum (pea aphid) 70263 Branchiostoma floridae (lancelet) BGIBMGA013392-PA Bombyx mori (silk worm) ENSBTAP00000027259 Bos taurus (bovine) CBP33999 Caenorhabditis briggsae (nematode) CE37905 Caenorhabditis elegans (worm) ENSCAFP00000001606 Canis familiaris (dog) JA02276 Caenorhabditis japonica (nematode) CPIJ012217 Culex pipens (mosquito) ENSCPOP00000004547 Cavia porcellus (guinea pig) 194442 Chlamidomonas reinhardtii (green alga) RP44614 Caenorhabditis remanei (nematode) ENSCSAVP00000010505 Ciona savignyi (sedentary tunicate) 222687 Capitella spl (polychaete worm) DDB0201571 Dictyostelium discoideum (amoeba) 227934 Daphnia pulex (daphnia) ENSDARP00000065091 Danio rerio (zebra fish) ENSECAP00000019394 Equus caballus (horse) ENSGACP00000000845 Gymnopilus aculeatus (mushroom) ENSGALP00000013490 Gallus gallus (chicken) 194356 Hypsipyla robusta (cedar shoot borer) ENSP00000349029 Homo sapiens (human) ISCW023346-PA Ixodes scapularis (deer tick) 236387 Lottia gigantea (owl limpet) LmjF16.0280 Leishmania major (virus) 37956 Monocosta brevicollis (choanoflagellate) ENSMODP00000005545 Monodelphis domestica (gray opossum) ENSMMUP00000039666 Macaca mulatta (rhesus monkey) ENSMUSP00000032192 Mus musculus (house mouse) 244707 Nematostella vectensis (starlet anemone) XP_001607257.1 Nasonia vitripennis (wasp) ENSOANP00000017849 Ornithorynchus anatinus (platypus) ENSORLP00000018255 Oryzias latipes (japanese killifish) PHUM000508-PA Pediculus humanus (human body louse) ENSPPYP00000015317 Pongo pygmaeus (orangutan) ENSPTRP00000025124 Pan troglodytes (chimpanzee) ENSRNOP00000009288 Rattus norvegicus (norway rat) 56365 Trichoplax adhaerens (metazoa) XP_971835.2 Tribolium castaneum (red flour beetle) Tc00.1047053509461.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005002 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037199 Takifugu rubripes (pufferfish Takifugu) 186.m00076 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000011267 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17334 NV12070 LH16470 ISCW023346 FBgn0242542 FBgn0217337 FBgn0209806 FBgn0191280 FBgn0172765 FBgn0168511 FBgn0165759 JGI_V11_122660 JGI_V11_99490 JGI_V11_114608 JGI_V11_254866 JGI_V11_227934 JGI_V11_307680 JGI_V11_7943 FBgn0070509 FBgn0159261 FBgn0145809 FBgn0126067 FBgn0105146 FBgn0094275 CPIJ012217 CPIJ012215 BGIBMGA013392 ACYPI004695 GB11927 AGAP006475 AAEL014637 AAEL003608 PHUM216220 GLEAN_05176
Stocks & Reagents
Stocks Listed in FlyBase ( 17 )
Bloomington	30742 P{UAS-Itp-r83A.V}1, w* 30737 Itp-r83A90B.0/TM6B, Tb1 25937 y1 v1; P{TRiP.JF01957}attP2 24079 w1118; Mi{ET1}Itp-r83AMB03611 30738 w*; Itp-r83Aug3/TM6B, Tb1 30740 w*; Itp-r83Asv35/TM6B, Tb1
Harvard	- P{XP}Itp-r83Ad01974 - PBac{WH}Itp-r83Af03103
Kyoto	123005 w1118; P{RS3}Itp-r83ACB-0011-3
VDRC	v106982 P{KK100626}VIE-260B v6484 w1118; P{GD1676}v6484 v6486 w1118; P{GD1676}v6486
	More stocks available...
Genomic Clones ( 2 )
	BACR24O24 BACR34M23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	74839 103246 109052 147702 562207 CK01.53D.D3 EK043414 EK207146 EK263721 EN13919
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0010051 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40664
Antibody Information
	polyclonal (Srikanth et al., 2004, Raghu et al., 2000)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Itp-r83A CG1063 (Zheng, 1999.11)
Source for database merge of	Source for merge of: Itp-r83A anon-WO02059370.49 (FlyBase, 1996-)
Additional comments	Source for merge of Itp-r83A anon-WO02059370.49 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) Itp-r83A-triggered calcium release is a signal that is necessary for both entry into mitosis and for anaphase onset in syncytial Drosophila embryos. (Parry et al., 2005) Both Itp-r83A and rut signalling pathways are involved in regulating larval molting. Regulation of 20-hydroxyecdysone peaks during larval molting may operate through a feedback loop requiring Pka-C1 and the Itp-r83A receptor. (Venkatesh et al., 2001) Itp-r83A is essential for growth and differentiation, but does not play a role in the activation of the light response in photoreceptor cells. (Acharya et al., 1997) A baculovirus (BV)/Sf (S.frugiperda) cell system is developed that can be used to look at Itp-r83A function. (Raghu et al., 1997) Disruption of the Itp-r83A gene leads to lowered levels of ecdysone. (Venkatesh and Hasan, 1997) Expression pattern analysis suggests that the IP3 signalling pathway is used during muscle development, primarily when myoblasts undergo rapid multiplication, in both embryos and pupae. In adults IP3 is probably a second messenger in more than one sensory transduction pathway. (Raghu and Hasan, 1995) The Drosophila IP3 receptor gene was cloned by PCR with degenerate oligonucleotides. (Hasan and Rosbash, 1992) A cDNA for the inositol 1,4,5-tris-phosphate receptor by sequence similarity to the mouse gene. The Drosophila sequence was tested in NG108-15 transient assay and the protein encoded shown to bind 3H-inositol 1,4,5-tris-phosphate, showing functional similarity to the mouse protein. (Yoshikawa et al., 1992)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_169060 NM_169061 RefSeq (Proteins) • NP_730941 NP_730942 DDBJ / EMBL / GenBank • AAF52015 AAN13240 AJ238949 AQ034066 AX664475 BAA14399 BZ748900 BZ748901 CAA79220 CAB51853 CZ472543 CZ472544 D90403 Z18535 Entrez Gene - A searchable database of RefSeq genes. • 40664 UniProtKB/Swiss-Prot • P29993
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Inositol 1,4,5-trisphosphate-binding protein receptor (IPR000493) Intracellular calcium-release channel (IPR000699) MIR (IPR003608) Ion transport (IPR005821) RyR/IP3R Homology associated domain (IPR013662) Ryanodine receptor-related (IPR015925) Inositol 1,4,5-trisphosphate/ryanodine receptor (IPR014821) MIR motif (IPR016093)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65871 DroID - A comprehensive database of gene and protein interactions. • FBgn0010051 DRSC - Results from RNAi screens. • FBgn0010051 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0010051 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1063-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0010051 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40664 InParanoid A subset of ortholog calls from InParanoid. • AAEL014637-PA Aedes aegypti (mosquito) AGAP006475-PA Anopheles gambiae (mosquito) XP_392236.3 Apis mellifera (honey bee) XP_001947344.1 Acyrthosiphon pisum (pea aphid) 70263 Branchiostoma floridae (lancelet) BGIBMGA013392-PA Bombyx mori (silk worm) ENSBTAP00000027259 Bos taurus (bovine) CBP33999 Caenorhabditis briggsae (nematode) CE37905 Caenorhabditis elegans (worm) ENSCAFP00000001606 Canis familiaris (dog) JA02276 Caenorhabditis japonica (nematode) CPIJ012217 Culex pipens (mosquito) ENSCPOP00000004547 Cavia porcellus (guinea pig) 194442 Chlamidomonas reinhardtii (green alga) RP44614 Caenorhabditis remanei (nematode) ENSCSAVP00000010505 Ciona savignyi (sedentary tunicate) 222687 Capitella spl (polychaete worm) DDB0201571 Dictyostelium discoideum (amoeba) 227934 Daphnia pulex (daphnia) ENSDARP00000065091 Danio rerio (zebra fish) ENSECAP00000019394 Equus caballus (horse) ENSGACP00000000845 Gymnopilus aculeatus (mushroom) ENSGALP00000013490 Gallus gallus (chicken) 194356 Hypsipyla robusta (cedar shoot borer) ENSP00000349029 Homo sapiens (human) ISCW023346-PA Ixodes scapularis (deer tick) 236387 Lottia gigantea (owl limpet) LmjF16.0280 Leishmania major (virus) 37956 Monocosta brevicollis (choanoflagellate) ENSMODP00000005545 Monodelphis domestica (gray opossum) ENSMMUP00000039666 Macaca mulatta (rhesus monkey) ENSMUSP00000032192 Mus musculus (house mouse) 244707 Nematostella vectensis (starlet anemone) XP_001607257.1 Nasonia vitripennis (wasp) ENSOANP00000017849 Ornithorynchus anatinus (platypus) ENSORLP00000018255 Oryzias latipes (japanese killifish) PHUM000508-PA Pediculus humanus (human body louse) ENSPPYP00000015317 Pongo pygmaeus (orangutan) ENSPTRP00000025124 Pan troglodytes (chimpanzee) ENSRNOP00000009288 Rattus norvegicus (norway rat) 56365 Trichoplax adhaerens (metazoa) XP_971835.2 Tribolium castaneum (red flour beetle) Tc00.1047053509461.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005002 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000037199 Takifugu rubripes (pufferfish Takifugu) 186.m00076 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000011267 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/ino3pr1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40664 modMine - Data generated by the modENCODE project. • FBgn0010051 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17334 NV12070 LH16470 ISCW023346 FBgn0242542 FBgn0217337 FBgn0209806 FBgn0191280 FBgn0172765 FBgn0168511 FBgn0165759 JGI_V11_122660 JGI_V11_99490 JGI_V11_114608 JGI_V11_254866 JGI_V11_227934 JGI_V11_307680 JGI_V11_7943 FBgn0070509 FBgn0159261 FBgn0145809 FBgn0126067 FBgn0105146 FBgn0094275 CPIJ012217 CPIJ012215 BGIBMGA013392 ACYPI004695 GB11927 AGAP006475 AAEL014637 AAEL003608 PHUM216220 GLEAN_05176
Synonyms & Secondary IDs ( 38 )
Reported As
Symbol Synonym	anon-WO02059370.49   CG1063 (Whitfield, 2000.4.28, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Venkiteswaran and Hasan, 2009) dip (Hardie, 2001, Hasan, 1993, Hasan and Rosbash, 1992, ) DIP (Hasan, 1992.11.20) DmInsP3R (Srikanth et al., 2004) DmInsP3R (Srikanth et al., 2004) Insp3R   InsP3 (Sullivan et al., 2000, Parry et al., 2005) InsP3R (Harteneck, 2003, Hardie, 2001, Acharya et al., 1997, Banerjee and Hasan, 2005, Raghu et al., 2000, Agrawal et al., 2010, McBride et al., 2010) IP   IP3R (Pontig, 2000, Brill et al., 2005, Nelson et al., 2005) IP3R (Delmas et al., 2004, Towers and Sattelle, 2002, Blumenthal, 2001, Montell, 1999, Sinha and Hasan, 1999, Venkatesan and Hasan, 1997, Raghu et al., 1997, Takeshima et al., 1994, Selinger et al., 1993, Vazquez-Martinez et al., 2003, Murillo-Maldonado et al., 2008) IP3 receptor (Swatton et al., 2001) itpr (Deshpande et al., 2000, Joshi et al., 2005, Srikanth et al., 2004, Srikanth et al., 2004, Joshi et al., 2004, Joshi et al., 2004, Pollock et al., 2003, Monnier et al., 2002, Joshi et al., 2002, Hasan et al., 2001, Venkatesh et al., 2001, Sorrentino et al., 2000, Pollock et al., 2000, Hasan, 1999.5.8, Sinha and Hasan, 1999, Hasan, 1998, Venkatesh and Hasan, 1997, Banerjee and Hasan, 2005, Banerjee et al., 2004, Banerjee et al., 2006, Usui-Aoki et al., 2005, Venkiteswaran and Hasan, 2009, Pollock et al., 2003, Agrawal et al., 2009, Kain et al., 2008, Agrawal et al., 2010, Nair et al., 2007) Itp-r   Itp-r42B   itpr-83 (Pollock et al., 2003) Itp-r83A (Christensen et al., 2007.3.22, Kobayashi et al., 2006, Kaltenbach et al., 2007, Dierick and Greenspan, 2006, Qian and Bodmer, 2009, Wang et al., 2004) ITP-r83A (Gim et al., 2001) Itp-r1 (Sullivan et al., 2000) l(3)05616 (O'Connor, 2000.1.4, ) l(3)itpr (Krause et al., 2008, Raghu et al., 2000) l(3)j5B4   unnamed (Littleton and Ganetzky, 2000)
Name Synonym	dm_IP3 receptor (Hoover and Bryant, 2000) Inositol 1,4,5,-tris-phosphate receptor (Yoshikawa et al., 1992, Qian and Bodmer, 2009) inositol 1,4,5-triphosphate receptor (Venkiteswaran and Hasan, 2009) inositol 1,4,5-trisphosphate (InsP3 ) receptor (Banerjee et al., 2004) inositol 1,4,5-trisphosphate receptor (Yoshikawa, 1993.1.23, Padinjat and Andrews, 2004) inositol-1,4,5-trisphosphate receptor (Raghu et al., 2000) Inositol 1,4,5-trisphosphate receptor (Gim et al., 2001) Inositol(1,4,5)-triphosphate receptor 42B   inositol triphosphate receptor 1 (Nelson et al., 2005) inositol trisphosphate receptor (McBride et al., 2010) Ins(1,4,5)P3 receptor (Padinjat and Andrews, 2004) InsP3 receptor (Banerjee and Hasan, 2005, Parry et al., 2005, Raghu et al., 2000) IP3 receptor (Thummel, 2001) IP3 receptor (Vazquez-Martinez et al., 2003) Itp-r83A (Kaltenbach et al., 2007) Type 1 InsP{3} receptor (Parry et al., 2005)
Secondary FlyBase IDs
	FBgn0010234 FBgn0010870 FBgn0011378 FBgn0023199 FBgn0066011
References ( 101 )
Generate a list of	All references relating to this gene ( 101 )
List References by type	Research paper  ( 46 ) Supplementary material  ( 2 ) Review  ( 15 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Computer file  ( 3 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 4 )
	Kumar et al., 2011, PLoS ONE 6(8): e24105 Patterns of Gene Expression in Drosophila InsP(3) Receptor Mutant Larvae Reveal a Role for InsP(3) Signaling in Carbohydrate and Energy Metabolism. [FBrf0215561] Murmu et al., 2011, BMC Neurosci. 12: 105 Calcium-stores mediate adaptation in axon terminals of Olfactory Receptor Neurons in Drosophila. [FBrf0216769] Agrawal et al., 2010, J. Neurosci. 30(4): 1301--1313 Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight. [FBrf0209847] McBride et al., 2010, J. Neurosci. 30(28): 9510--9522 Pharmacological and genetic reversal of age-dependent cognitive deficits attributable to decreased presenilin function. [FBrf0211297] Show all research papers ...
Recent reviews ( 1 )
	Hasan and Venkiteswaran, 2010, Front. Neural Circuits 4: 10 The enigma of store-operated ca-entry in neurons: answers from the Drosophila flight circuit. [FBrf0210703] Show all reviews ...